Amy Lauer, PA-C, MPAS, MS

 

To the Editor:

Cutaneous reactions to implantable devices, such as dental implants, intracoronary stents, prosthetic valves, endovascular prostheses, gynecologic devices, and spinal cord stimulator devices, occur with varying frequency and include infectious, hypersensitivity, allergic, and foreign-body reactions. Manifestations have included contact dermatitis; urticarial, vasculitic, and bullous eruptions; extrusion; and granuloma formation.^1,2 Immune complex reactions around implants causing pain, inflammation, and loosening of hardwarealso have been reported.^3,4 Most reported cutaneous reactions typically occur within the first weeks or months after implantation; a reaction rarely presents several years after implantation. We report a cutaneous reaction to an orthopedic appliance almost 10 years after implantation.

A 67-year-old man presented with 2 painful nodules on the right clavicle that were present for several months. The patient denied fever, chills, weight loss, enlarged lymph nodes, or night sweats. Approximately 10 years prior to the appearance of the nodules, the patient fractured the right clavicle and underwent placement of a metal plate. His medical history included resection of the right tonsil and soft-palate carcinoma with radical neck dissection and postoperative radiation, which was completed approximately 4 years prior to placement of the metal plate. The patient recently completed 4 to 6 weeks of fluorouracil for shave biopsy–proven actinic keratosis overlying the entire irradiated area.

Physical examination revealed 2 pink friable nodules measuring 1.5 to 2.5 cm in diameter and leaking serous fluid within the irradiated area (Figure 1). The differential diagnosis included pyogenic granuloma, cutaneous recurrent metastasis, and atypical basal cell carcinoma. A skin biopsy specimen showed hemorrhagic ulcerated skin with acute and chronic inflammation and abscess.

The patient presented for excisional biopsy of these areas on the right medial clavicle 1 week later. Physical examination revealed the 2 nodules had decreased in diameter; now, however, the patient had 4 discrete lesions measuring 4 to 7 mm in diameter, which were similar in appearance to the earlier nodules (Figure 2). He reported a low-grade fever, erythema, and increased tenderness of the area.

Underlying loosened orthopedic hardware screws were revealed upon punch biopsies of the involved areas (Figure 3). Wound cultures showed abundant Staphylococcus aureus and moderate group B Streptococcus; cultures for Mycobacterium were negative. The C-reactive protein level was elevated (5.47 mg/dL [reference range, ≤0.7 mg/dL]), and the erythrocyte sedimentation rate was increased (68 mm/h [reference range, 0–15 mm/h]). A complete blood cell count was within reference range, except for a mildly elevated eosinophil count (6.7% [reference range, 0%–5%]). The patient was admitted to the hospital, and antibiotics were started. Two days later, the orthopedic surgery service removed the hardware. At 3-week follow-up, physical examination revealed near closure of the wounds.

Cutaneous reactions to orthopedic implants include dermatitis, as well as urticarial, vasculitic, and bullous eruptions. Immune complex reactions can develop around implants, causing pain, inflammation, and loosening of hardware.^1,3 Most inflammatory reactions take place within several months after implantation.³ Our patient’s reaction to hardware 10 years after implantation highlights the importance of taking a detailedand thorough history that includes queries about distant surgery.

 

To the Editor:

Cutaneous reactions to implantable devices, such as dental implants, intracoronary stents, prosthetic valves, endovascular prostheses, gynecologic devices, and spinal cord stimulator devices, occur with varying frequency and include infectious, hypersensitivity, allergic, and foreign-body reactions. Manifestations have included contact dermatitis; urticarial, vasculitic, and bullous eruptions; extrusion; and granuloma formation.^1,2 Immune complex reactions around implants causing pain, inflammation, and loosening of hardwarealso have been reported.^3,4 Most reported cutaneous reactions typically occur within the first weeks or months after implantation; a reaction rarely presents several years after implantation. We report a cutaneous reaction to an orthopedic appliance almost 10 years after implantation.

A 67-year-old man presented with 2 painful nodules on the right clavicle that were present for several months. The patient denied fever, chills, weight loss, enlarged lymph nodes, or night sweats. Approximately 10 years prior to the appearance of the nodules, the patient fractured the right clavicle and underwent placement of a metal plate. His medical history included resection of the right tonsil and soft-palate carcinoma with radical neck dissection and postoperative radiation, which was completed approximately 4 years prior to placement of the metal plate. The patient recently completed 4 to 6 weeks of fluorouracil for shave biopsy–proven actinic keratosis overlying the entire irradiated area.

Physical examination revealed 2 pink friable nodules measuring 1.5 to 2.5 cm in diameter and leaking serous fluid within the irradiated area (Figure 1). The differential diagnosis included pyogenic granuloma, cutaneous recurrent metastasis, and atypical basal cell carcinoma. A skin biopsy specimen showed hemorrhagic ulcerated skin with acute and chronic inflammation and abscess.

The patient presented for excisional biopsy of these areas on the right medial clavicle 1 week later. Physical examination revealed the 2 nodules had decreased in diameter; now, however, the patient had 4 discrete lesions measuring 4 to 7 mm in diameter, which were similar in appearance to the earlier nodules (Figure 2). He reported a low-grade fever, erythema, and increased tenderness of the area.

Underlying loosened orthopedic hardware screws were revealed upon punch biopsies of the involved areas (Figure 3). Wound cultures showed abundant Staphylococcus aureus and moderate group B Streptococcus; cultures for Mycobacterium were negative. The C-reactive protein level was elevated (5.47 mg/dL [reference range, ≤0.7 mg/dL]), and the erythrocyte sedimentation rate was increased (68 mm/h [reference range, 0–15 mm/h]). A complete blood cell count was within reference range, except for a mildly elevated eosinophil count (6.7% [reference range, 0%–5%]). The patient was admitted to the hospital, and antibiotics were started. Two days later, the orthopedic surgery service removed the hardware. At 3-week follow-up, physical examination revealed near closure of the wounds.

Cutaneous reactions to orthopedic implants include dermatitis, as well as urticarial, vasculitic, and bullous eruptions. Immune complex reactions can develop around implants, causing pain, inflammation, and loosening of hardware.^1,3 Most inflammatory reactions take place within several months after implantation.³ Our patient’s reaction to hardware 10 years after implantation highlights the importance of taking a detailedand thorough history that includes queries about distant surgery.

 

To the Editor:

Cutaneous reactions to implantable devices, such as dental implants, intracoronary stents, prosthetic valves, endovascular prostheses, gynecologic devices, and spinal cord stimulator devices, occur with varying frequency and include infectious, hypersensitivity, allergic, and foreign-body reactions. Manifestations have included contact dermatitis; urticarial, vasculitic, and bullous eruptions; extrusion; and granuloma formation.^1,2 Immune complex reactions around implants causing pain, inflammation, and loosening of hardwarealso have been reported.^3,4 Most reported cutaneous reactions typically occur within the first weeks or months after implantation; a reaction rarely presents several years after implantation. We report a cutaneous reaction to an orthopedic appliance almost 10 years after implantation.

A 67-year-old man presented with 2 painful nodules on the right clavicle that were present for several months. The patient denied fever, chills, weight loss, enlarged lymph nodes, or night sweats. Approximately 10 years prior to the appearance of the nodules, the patient fractured the right clavicle and underwent placement of a metal plate. His medical history included resection of the right tonsil and soft-palate carcinoma with radical neck dissection and postoperative radiation, which was completed approximately 4 years prior to placement of the metal plate. The patient recently completed 4 to 6 weeks of fluorouracil for shave biopsy–proven actinic keratosis overlying the entire irradiated area.

Physical examination revealed 2 pink friable nodules measuring 1.5 to 2.5 cm in diameter and leaking serous fluid within the irradiated area (Figure 1). The differential diagnosis included pyogenic granuloma, cutaneous recurrent metastasis, and atypical basal cell carcinoma. A skin biopsy specimen showed hemorrhagic ulcerated skin with acute and chronic inflammation and abscess.

The patient presented for excisional biopsy of these areas on the right medial clavicle 1 week later. Physical examination revealed the 2 nodules had decreased in diameter; now, however, the patient had 4 discrete lesions measuring 4 to 7 mm in diameter, which were similar in appearance to the earlier nodules (Figure 2). He reported a low-grade fever, erythema, and increased tenderness of the area.

Underlying loosened orthopedic hardware screws were revealed upon punch biopsies of the involved areas (Figure 3). Wound cultures showed abundant Staphylococcus aureus and moderate group B Streptococcus; cultures for Mycobacterium were negative. The C-reactive protein level was elevated (5.47 mg/dL [reference range, ≤0.7 mg/dL]), and the erythrocyte sedimentation rate was increased (68 mm/h [reference range, 0–15 mm/h]). A complete blood cell count was within reference range, except for a mildly elevated eosinophil count (6.7% [reference range, 0%–5%]). The patient was admitted to the hospital, and antibiotics were started. Two days later, the orthopedic surgery service removed the hardware. At 3-week follow-up, physical examination revealed near closure of the wounds.

Cutaneous reactions to orthopedic implants include dermatitis, as well as urticarial, vasculitic, and bullous eruptions. Immune complex reactions can develop around implants, causing pain, inflammation, and loosening of hardware.^1,3 Most inflammatory reactions take place within several months after implantation.³ Our patient’s reaction to hardware 10 years after implantation highlights the importance of taking a detailedand thorough history that includes queries about distant surgery.