Onetime, Nondrug Treatment May Be Better for Some MS Patients

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Wed, 08/22/2018 - 11:15
Researchers find a onetime immunotherapy method to be highly promising in treating patients with relapsing multiple sclerosis.

High-dose immunosuppressive therapy and autologous hematopoietic cell transplant (HDIT/HCT) has had “highly promising” results for patients with relapsing-remitting multiple sclerosis (MS), according to researchers from the HALT-MS trial. In the 5-year study, 69% of 24 participants survived without progression of disability, relapse, or new brain lesions, despite not taking MS medications.

Findings published at the 3-year mark were encouraging. The event-free survival rate was 78%. The extended findings suggest that “onetime treatment with HDIT/HCT may be substantially more effective than long-term treatment with the best available medications” for these patients, said NIAID Director Anthony Fauci, MD.

The treatment “resets” the immune system, the researchers say. First, doctors collect the patient’s blood-forming stem cells, then give the patient chemotherapy to deplete the immune system. Finally, the doctors return the patient’s stem cells to rebuild the immune system.

Adverse events were consistent with those routinely observed after HDIT/HCT. Adverse effects recorded at 4 and 5 years were not related to the transplant and were not considered severe. Three patients died, but their deaths were not related to the study treatments.

Five years later, most trial participants remained in remission and stabilized, and some showed improvements, such as recovering mobility.

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Researchers find a onetime immunotherapy method to be highly promising in treating patients with relapsing multiple sclerosis.
Researchers find a onetime immunotherapy method to be highly promising in treating patients with relapsing multiple sclerosis.

High-dose immunosuppressive therapy and autologous hematopoietic cell transplant (HDIT/HCT) has had “highly promising” results for patients with relapsing-remitting multiple sclerosis (MS), according to researchers from the HALT-MS trial. In the 5-year study, 69% of 24 participants survived without progression of disability, relapse, or new brain lesions, despite not taking MS medications.

Findings published at the 3-year mark were encouraging. The event-free survival rate was 78%. The extended findings suggest that “onetime treatment with HDIT/HCT may be substantially more effective than long-term treatment with the best available medications” for these patients, said NIAID Director Anthony Fauci, MD.

The treatment “resets” the immune system, the researchers say. First, doctors collect the patient’s blood-forming stem cells, then give the patient chemotherapy to deplete the immune system. Finally, the doctors return the patient’s stem cells to rebuild the immune system.

Adverse events were consistent with those routinely observed after HDIT/HCT. Adverse effects recorded at 4 and 5 years were not related to the transplant and were not considered severe. Three patients died, but their deaths were not related to the study treatments.

Five years later, most trial participants remained in remission and stabilized, and some showed improvements, such as recovering mobility.

High-dose immunosuppressive therapy and autologous hematopoietic cell transplant (HDIT/HCT) has had “highly promising” results for patients with relapsing-remitting multiple sclerosis (MS), according to researchers from the HALT-MS trial. In the 5-year study, 69% of 24 participants survived without progression of disability, relapse, or new brain lesions, despite not taking MS medications.

Findings published at the 3-year mark were encouraging. The event-free survival rate was 78%. The extended findings suggest that “onetime treatment with HDIT/HCT may be substantially more effective than long-term treatment with the best available medications” for these patients, said NIAID Director Anthony Fauci, MD.

The treatment “resets” the immune system, the researchers say. First, doctors collect the patient’s blood-forming stem cells, then give the patient chemotherapy to deplete the immune system. Finally, the doctors return the patient’s stem cells to rebuild the immune system.

Adverse events were consistent with those routinely observed after HDIT/HCT. Adverse effects recorded at 4 and 5 years were not related to the transplant and were not considered severe. Three patients died, but their deaths were not related to the study treatments.

Five years later, most trial participants remained in remission and stabilized, and some showed improvements, such as recovering mobility.

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Artificial Pancreas Moves Closer to Real-Life Option

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Tue, 05/03/2022 - 15:30
A new fully automated system aims to reproduce the adjustment of insulin in patients with type 1 diabetes mellitus just as efficiently as a real pancreas.

Roughly 25% of veterans have diabetes mellitus (DM) as opposed to 9% of the general public. A small percentage of veterans have type 1 DM, which according to research, can be caused by both physical and mental trauma that affects the pancreas.

 

“Managing type 1 diabetes currently requires a constant juggling act between checking bloodglucose levels frequently and delivering just the right amount of insulin while taking into account meals, physical activity, and other aspects of daily life, where a missed or wrong delivery could lead to potential complications,” said Dr. Andrew Bremer, of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). But that may change soon as we draw near to a functional “artificial pancreas,” a fully automated system that will sense rising glucose levels and adjust insulin automatically.

 The FDA approved a hybrid model of an artificial pancreas in 2016, which still required users to adjust insulin intake. Now, 4 separate projects are designed to be the “potential last steps” toward requesting regulatory approval for permanent use of a fully automated system, according to NIDDK. The research studies beginning this year will look at safety, efficacy, user-friendliness, physical and emotional health of participants, and cost. The participants will live at home and monitor themselves with remote monitoring by study staff.

“Nearly 100 years since the discovery of insulin,” said NIDDK Director Dr. Griffin P. Rodgers, “a successful artificial pancreas would mark another huge step toward better health for people with type 1 diabetes.”

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A new fully automated system aims to reproduce the adjustment of insulin in patients with type 1 diabetes mellitus just as efficiently as a real pancreas.
A new fully automated system aims to reproduce the adjustment of insulin in patients with type 1 diabetes mellitus just as efficiently as a real pancreas.

Roughly 25% of veterans have diabetes mellitus (DM) as opposed to 9% of the general public. A small percentage of veterans have type 1 DM, which according to research, can be caused by both physical and mental trauma that affects the pancreas.

 

“Managing type 1 diabetes currently requires a constant juggling act between checking bloodglucose levels frequently and delivering just the right amount of insulin while taking into account meals, physical activity, and other aspects of daily life, where a missed or wrong delivery could lead to potential complications,” said Dr. Andrew Bremer, of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). But that may change soon as we draw near to a functional “artificial pancreas,” a fully automated system that will sense rising glucose levels and adjust insulin automatically.

 The FDA approved a hybrid model of an artificial pancreas in 2016, which still required users to adjust insulin intake. Now, 4 separate projects are designed to be the “potential last steps” toward requesting regulatory approval for permanent use of a fully automated system, according to NIDDK. The research studies beginning this year will look at safety, efficacy, user-friendliness, physical and emotional health of participants, and cost. The participants will live at home and monitor themselves with remote monitoring by study staff.

“Nearly 100 years since the discovery of insulin,” said NIDDK Director Dr. Griffin P. Rodgers, “a successful artificial pancreas would mark another huge step toward better health for people with type 1 diabetes.”

Roughly 25% of veterans have diabetes mellitus (DM) as opposed to 9% of the general public. A small percentage of veterans have type 1 DM, which according to research, can be caused by both physical and mental trauma that affects the pancreas.

 

“Managing type 1 diabetes currently requires a constant juggling act between checking bloodglucose levels frequently and delivering just the right amount of insulin while taking into account meals, physical activity, and other aspects of daily life, where a missed or wrong delivery could lead to potential complications,” said Dr. Andrew Bremer, of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). But that may change soon as we draw near to a functional “artificial pancreas,” a fully automated system that will sense rising glucose levels and adjust insulin automatically.

 The FDA approved a hybrid model of an artificial pancreas in 2016, which still required users to adjust insulin intake. Now, 4 separate projects are designed to be the “potential last steps” toward requesting regulatory approval for permanent use of a fully automated system, according to NIDDK. The research studies beginning this year will look at safety, efficacy, user-friendliness, physical and emotional health of participants, and cost. The participants will live at home and monitor themselves with remote monitoring by study staff.

“Nearly 100 years since the discovery of insulin,” said NIDDK Director Dr. Griffin P. Rodgers, “a successful artificial pancreas would mark another huge step toward better health for people with type 1 diabetes.”

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When Grief Becomes a Syndrome

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Wed, 08/22/2018 - 11:15
Researchers study data from National Institute of Mental Health studies to better understand diagnosing and treating patients with “persistent impairing grief.”

Some patients who experience long-term grief may be slipping through the health care net. With data collected in 2 National Institute of Mental Health-funded treatment studies, researchers used proposed criteria from DSM-5 to identify patients with a stress-response syndrome of “persistent impairing grief”—that is, persistent complex bereavement disorder (PCBD), prolonged grief disorder (BGD) and complicated grief (CG). They studied 2 groups of patients in university-based psychiatric research clinics: 240 grief-treatment seeking participants scored ≥ 30 on the Inventory of Complicated Grief (ICG), and 86 bereaved adults scored < 20 on the ICG.

The PCBD criteria diagnosed 70% of the first group, PGD criteria identified 59.6%, and CG criteria identified 99.6%. None of the 3 proposed criteria identified cases in the bereaved comparison group. Only the CG criteria produced rates of case identification sufficient to be of clinical utility, the researchers say.

Their findings are “virtually identical” with those of the community-based National Military Family Bereavement Study, the researchers say, in which all 3 criteria sets identified < 2% of the bereaved military family survey population that scored < 20 on the ICG.

There are treatments specific to grief, the researchers note. But as of yet there is no gold standard for diagnosing persistent impairing grief. The researchers say the solution could lie in using the CG criteria set and modifying decision rules for CBD or PGD criteria or developing a new group of symptoms and decision rules. However it’s done, the researchers conclude, they see a “pressing need” to establish criteria that can lead to correct diagnosis and targeted treatment.

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Researchers study data from National Institute of Mental Health studies to better understand diagnosing and treating patients with “persistent impairing grief.”
Researchers study data from National Institute of Mental Health studies to better understand diagnosing and treating patients with “persistent impairing grief.”

Some patients who experience long-term grief may be slipping through the health care net. With data collected in 2 National Institute of Mental Health-funded treatment studies, researchers used proposed criteria from DSM-5 to identify patients with a stress-response syndrome of “persistent impairing grief”—that is, persistent complex bereavement disorder (PCBD), prolonged grief disorder (BGD) and complicated grief (CG). They studied 2 groups of patients in university-based psychiatric research clinics: 240 grief-treatment seeking participants scored ≥ 30 on the Inventory of Complicated Grief (ICG), and 86 bereaved adults scored < 20 on the ICG.

The PCBD criteria diagnosed 70% of the first group, PGD criteria identified 59.6%, and CG criteria identified 99.6%. None of the 3 proposed criteria identified cases in the bereaved comparison group. Only the CG criteria produced rates of case identification sufficient to be of clinical utility, the researchers say.

Their findings are “virtually identical” with those of the community-based National Military Family Bereavement Study, the researchers say, in which all 3 criteria sets identified < 2% of the bereaved military family survey population that scored < 20 on the ICG.

There are treatments specific to grief, the researchers note. But as of yet there is no gold standard for diagnosing persistent impairing grief. The researchers say the solution could lie in using the CG criteria set and modifying decision rules for CBD or PGD criteria or developing a new group of symptoms and decision rules. However it’s done, the researchers conclude, they see a “pressing need” to establish criteria that can lead to correct diagnosis and targeted treatment.

Some patients who experience long-term grief may be slipping through the health care net. With data collected in 2 National Institute of Mental Health-funded treatment studies, researchers used proposed criteria from DSM-5 to identify patients with a stress-response syndrome of “persistent impairing grief”—that is, persistent complex bereavement disorder (PCBD), prolonged grief disorder (BGD) and complicated grief (CG). They studied 2 groups of patients in university-based psychiatric research clinics: 240 grief-treatment seeking participants scored ≥ 30 on the Inventory of Complicated Grief (ICG), and 86 bereaved adults scored < 20 on the ICG.

The PCBD criteria diagnosed 70% of the first group, PGD criteria identified 59.6%, and CG criteria identified 99.6%. None of the 3 proposed criteria identified cases in the bereaved comparison group. Only the CG criteria produced rates of case identification sufficient to be of clinical utility, the researchers say.

Their findings are “virtually identical” with those of the community-based National Military Family Bereavement Study, the researchers say, in which all 3 criteria sets identified < 2% of the bereaved military family survey population that scored < 20 on the ICG.

There are treatments specific to grief, the researchers note. But as of yet there is no gold standard for diagnosing persistent impairing grief. The researchers say the solution could lie in using the CG criteria set and modifying decision rules for CBD or PGD criteria or developing a new group of symptoms and decision rules. However it’s done, the researchers conclude, they see a “pressing need” to establish criteria that can lead to correct diagnosis and targeted treatment.

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Some Patients Are Not Getting the HIV Care They Need

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Wed, 08/22/2018 - 11:23
Data from the National HIV Surveillance suggests black patients are not getting as much care as white patients after diagnosis.

Fewer blacks than whites receive HIV medical care, according to a February 2017 Morbidity and Mortality Reports.

CDC researchers used National HIV Surveillance System data from people diagnosed with HIV through 2012 who were alive at year-end 2013. Of those cases, 68.1% of blacks vs 74.4% of whites received any HIV medical care. About half (53.5%) of blacks received continuous HIV medical care, as did 58.2% of whites. Of the 2 groups, 48.5% of blacks and 62% of whites achieved viral suppression.

Among patients with HIV infection diagnosed in 2014, 21.9% of blacks and 22.5% of whites were classified with HIV stage 3 (AIDS). Stage 3 infections were most common in patients aged > 55 years. Of diagnosed patients, 71.6% of blacks and 79% of whites were linked to care within 1 month after diagnosis.

The lowest levels of care and viral suppression were found among people with infection attributed to injection drug use and men with infection attributed to heterosexual contact. Linkage to care and viral load suppression were lower among people aged < 35 years.

To reach the 2020 national goals set for HIV/AIDS—85% linkage to care, 90% retention in care, and 80% viral load suppression—the CDC says tailored strategies are critical to getting more black patients with HIV into care. Prompt linkage after diagnosis allows HIV treatments to start sooner, reducing morbidity, mortality, and transmission of HIV.

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Data from the National HIV Surveillance suggests black patients are not getting as much care as white patients after diagnosis.
Data from the National HIV Surveillance suggests black patients are not getting as much care as white patients after diagnosis.

Fewer blacks than whites receive HIV medical care, according to a February 2017 Morbidity and Mortality Reports.

CDC researchers used National HIV Surveillance System data from people diagnosed with HIV through 2012 who were alive at year-end 2013. Of those cases, 68.1% of blacks vs 74.4% of whites received any HIV medical care. About half (53.5%) of blacks received continuous HIV medical care, as did 58.2% of whites. Of the 2 groups, 48.5% of blacks and 62% of whites achieved viral suppression.

Among patients with HIV infection diagnosed in 2014, 21.9% of blacks and 22.5% of whites were classified with HIV stage 3 (AIDS). Stage 3 infections were most common in patients aged > 55 years. Of diagnosed patients, 71.6% of blacks and 79% of whites were linked to care within 1 month after diagnosis.

The lowest levels of care and viral suppression were found among people with infection attributed to injection drug use and men with infection attributed to heterosexual contact. Linkage to care and viral load suppression were lower among people aged < 35 years.

To reach the 2020 national goals set for HIV/AIDS—85% linkage to care, 90% retention in care, and 80% viral load suppression—the CDC says tailored strategies are critical to getting more black patients with HIV into care. Prompt linkage after diagnosis allows HIV treatments to start sooner, reducing morbidity, mortality, and transmission of HIV.

Fewer blacks than whites receive HIV medical care, according to a February 2017 Morbidity and Mortality Reports.

CDC researchers used National HIV Surveillance System data from people diagnosed with HIV through 2012 who were alive at year-end 2013. Of those cases, 68.1% of blacks vs 74.4% of whites received any HIV medical care. About half (53.5%) of blacks received continuous HIV medical care, as did 58.2% of whites. Of the 2 groups, 48.5% of blacks and 62% of whites achieved viral suppression.

Among patients with HIV infection diagnosed in 2014, 21.9% of blacks and 22.5% of whites were classified with HIV stage 3 (AIDS). Stage 3 infections were most common in patients aged > 55 years. Of diagnosed patients, 71.6% of blacks and 79% of whites were linked to care within 1 month after diagnosis.

The lowest levels of care and viral suppression were found among people with infection attributed to injection drug use and men with infection attributed to heterosexual contact. Linkage to care and viral load suppression were lower among people aged < 35 years.

To reach the 2020 national goals set for HIV/AIDS—85% linkage to care, 90% retention in care, and 80% viral load suppression—the CDC says tailored strategies are critical to getting more black patients with HIV into care. Prompt linkage after diagnosis allows HIV treatments to start sooner, reducing morbidity, mortality, and transmission of HIV.

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Hearing Loss in People With Good Hearing

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Wed, 08/22/2018 - 11:23
Data from a recent CDC report shows that about 25% of adults who think they have good hearing have hearing damage.

About 1 in 4 American adults who say they have good or excellent hearing has hearing damage. According to a Vital Signs report, much of the damage is due to everyday loud sounds, such as leaf blowers, concerts, even portable devices. The rumble of a washing machine approaches the 85 decibels at which extended exposure can cause hearing damage. Sixty seconds of listening to a nearby siren (120 dB) also can cause hearing damage.

CDC researchers analyzed > 3,500 hearing tests conducted on adult participants in the 2012 National Health and Nutrition Examination Survey. Of those participants, 20% who reported no job-related noise exposure nonetheless had hearing damage in a pattern usually caused by noise.

People may delay reporting hearing loss because they don’t know or won’t admit they have a problem, the CDC says. Only 46% of adults who reported having trouble hearing saw a health care provider (HCP) for their hearing in the past 5 years. But chronic noise exposure has been associated with worsening heart disease, increased blood pressure, and other adverse health effects.

The CDC suggests HCPs ask patients (even those as young as 20) about their hearing. For instance, they can ask, “Do you find it difficult to follow a conversation if there is background noise?” and “Can you usually hear and understand what someone says in a normal tone of voice when you can’t see that person’s face?”

At routine health care visits, the CDC suggests HCPs explain to patients how noise exposure can permanently damage hearing. They also suggest recommending earplugs or noise-canceling headphones. About 70% of people exposed to loud noise never or seldom wear hearing protection, CDC says.  The CDC suggests advising patients to turn down the volume when watching TV, listening to music, and using earbuds or headphones, as well as asking whether patients are taking medicines that increase the risk of hearing damage. If patients show or report hearing problems, the CDC suggests HCPs examine their hearing or refer them to a hearing specialist.

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Data from a recent CDC report shows that about 25% of adults who think they have good hearing have hearing damage.
Data from a recent CDC report shows that about 25% of adults who think they have good hearing have hearing damage.

About 1 in 4 American adults who say they have good or excellent hearing has hearing damage. According to a Vital Signs report, much of the damage is due to everyday loud sounds, such as leaf blowers, concerts, even portable devices. The rumble of a washing machine approaches the 85 decibels at which extended exposure can cause hearing damage. Sixty seconds of listening to a nearby siren (120 dB) also can cause hearing damage.

CDC researchers analyzed > 3,500 hearing tests conducted on adult participants in the 2012 National Health and Nutrition Examination Survey. Of those participants, 20% who reported no job-related noise exposure nonetheless had hearing damage in a pattern usually caused by noise.

People may delay reporting hearing loss because they don’t know or won’t admit they have a problem, the CDC says. Only 46% of adults who reported having trouble hearing saw a health care provider (HCP) for their hearing in the past 5 years. But chronic noise exposure has been associated with worsening heart disease, increased blood pressure, and other adverse health effects.

The CDC suggests HCPs ask patients (even those as young as 20) about their hearing. For instance, they can ask, “Do you find it difficult to follow a conversation if there is background noise?” and “Can you usually hear and understand what someone says in a normal tone of voice when you can’t see that person’s face?”

At routine health care visits, the CDC suggests HCPs explain to patients how noise exposure can permanently damage hearing. They also suggest recommending earplugs or noise-canceling headphones. About 70% of people exposed to loud noise never or seldom wear hearing protection, CDC says.  The CDC suggests advising patients to turn down the volume when watching TV, listening to music, and using earbuds or headphones, as well as asking whether patients are taking medicines that increase the risk of hearing damage. If patients show or report hearing problems, the CDC suggests HCPs examine their hearing or refer them to a hearing specialist.

About 1 in 4 American adults who say they have good or excellent hearing has hearing damage. According to a Vital Signs report, much of the damage is due to everyday loud sounds, such as leaf blowers, concerts, even portable devices. The rumble of a washing machine approaches the 85 decibels at which extended exposure can cause hearing damage. Sixty seconds of listening to a nearby siren (120 dB) also can cause hearing damage.

CDC researchers analyzed > 3,500 hearing tests conducted on adult participants in the 2012 National Health and Nutrition Examination Survey. Of those participants, 20% who reported no job-related noise exposure nonetheless had hearing damage in a pattern usually caused by noise.

People may delay reporting hearing loss because they don’t know or won’t admit they have a problem, the CDC says. Only 46% of adults who reported having trouble hearing saw a health care provider (HCP) for their hearing in the past 5 years. But chronic noise exposure has been associated with worsening heart disease, increased blood pressure, and other adverse health effects.

The CDC suggests HCPs ask patients (even those as young as 20) about their hearing. For instance, they can ask, “Do you find it difficult to follow a conversation if there is background noise?” and “Can you usually hear and understand what someone says in a normal tone of voice when you can’t see that person’s face?”

At routine health care visits, the CDC suggests HCPs explain to patients how noise exposure can permanently damage hearing. They also suggest recommending earplugs or noise-canceling headphones. About 70% of people exposed to loud noise never or seldom wear hearing protection, CDC says.  The CDC suggests advising patients to turn down the volume when watching TV, listening to music, and using earbuds or headphones, as well as asking whether patients are taking medicines that increase the risk of hearing damage. If patients show or report hearing problems, the CDC suggests HCPs examine their hearing or refer them to a hearing specialist.

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High Lead Levels From Old Bullet Fragments

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Wed, 08/22/2018 - 11:23
CDC research data reveal retained bullet fragments can lead to comorbidities years later if not removed.

Bullets and bullet fragments are not always removed if they don’t threaten the injured person’s life. But “retained” bullet fragments (RBFs) can lead to nonspecific symptoms of lead toxicity years later, such as, fatigue, abdominal pain, and memory loss.

Routine testing of adults with RBFs is infrequent, the CDC says. Usually, testing for blood levels of lead is done to monitor occupational exposure. But the number of people with RBFs who have toxic blood lead levels (BLLs) may be higher than thought. At BLLs ≥ 10 µg/dL, hypertension, kidney dysfunction, possible subclinical neurocognitive deficits, and adverse reproductive outcomes have been documented.

Related: The Long Legacy of Agent Orange

CDC researchers analyzed data from 41 states for 145,811 adults with elevated BLLs from all causes, reported by the Adult Blood Lead Epidemiology and Surveillance program from 2003 to 2012. Of those reported cases, 349 had levels ≥ 80 µg/dL. RBF-associated cases accounted for 0.3% of adults with elevated BLLs, but 4.9% of adults with BLLs ≥ 80 µg/dL. The maximum recorded RBF-associated BLL was 306 µg/dL. Further, RBF-associated cases were “overrepresented” among people with BLLs ≥ 80 µg/dL: 3.7%, compared with 0.2% of people without RBF-related elevated lead levels.

As of 2004, the researchers say, < 100 cases of lead toxicity caused by RBFs had been reported in the medical literature. They advise asking any patient who has elevated BLLs with an unknown lead exposure source about RBFs. A low index of suspicion could delay diagnosis or even contribute to an incorrect diagnosis.

Related: Cutting Down on Dialysis-Related Infections

Moreover, BLLs can fluctuate in people with RBFs, they note. A patient with a low BLL at the time of testing can have an increase in BLL and become symptomatic when RBFs migrate, such as into a joint space. The CDC researchers suggest baseline and intermittent BLL tests for people with a history of RBFs.

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CDC research data reveal retained bullet fragments can lead to comorbidities years later if not removed.
CDC research data reveal retained bullet fragments can lead to comorbidities years later if not removed.

Bullets and bullet fragments are not always removed if they don’t threaten the injured person’s life. But “retained” bullet fragments (RBFs) can lead to nonspecific symptoms of lead toxicity years later, such as, fatigue, abdominal pain, and memory loss.

Routine testing of adults with RBFs is infrequent, the CDC says. Usually, testing for blood levels of lead is done to monitor occupational exposure. But the number of people with RBFs who have toxic blood lead levels (BLLs) may be higher than thought. At BLLs ≥ 10 µg/dL, hypertension, kidney dysfunction, possible subclinical neurocognitive deficits, and adverse reproductive outcomes have been documented.

Related: The Long Legacy of Agent Orange

CDC researchers analyzed data from 41 states for 145,811 adults with elevated BLLs from all causes, reported by the Adult Blood Lead Epidemiology and Surveillance program from 2003 to 2012. Of those reported cases, 349 had levels ≥ 80 µg/dL. RBF-associated cases accounted for 0.3% of adults with elevated BLLs, but 4.9% of adults with BLLs ≥ 80 µg/dL. The maximum recorded RBF-associated BLL was 306 µg/dL. Further, RBF-associated cases were “overrepresented” among people with BLLs ≥ 80 µg/dL: 3.7%, compared with 0.2% of people without RBF-related elevated lead levels.

As of 2004, the researchers say, < 100 cases of lead toxicity caused by RBFs had been reported in the medical literature. They advise asking any patient who has elevated BLLs with an unknown lead exposure source about RBFs. A low index of suspicion could delay diagnosis or even contribute to an incorrect diagnosis.

Related: Cutting Down on Dialysis-Related Infections

Moreover, BLLs can fluctuate in people with RBFs, they note. A patient with a low BLL at the time of testing can have an increase in BLL and become symptomatic when RBFs migrate, such as into a joint space. The CDC researchers suggest baseline and intermittent BLL tests for people with a history of RBFs.

Bullets and bullet fragments are not always removed if they don’t threaten the injured person’s life. But “retained” bullet fragments (RBFs) can lead to nonspecific symptoms of lead toxicity years later, such as, fatigue, abdominal pain, and memory loss.

Routine testing of adults with RBFs is infrequent, the CDC says. Usually, testing for blood levels of lead is done to monitor occupational exposure. But the number of people with RBFs who have toxic blood lead levels (BLLs) may be higher than thought. At BLLs ≥ 10 µg/dL, hypertension, kidney dysfunction, possible subclinical neurocognitive deficits, and adverse reproductive outcomes have been documented.

Related: The Long Legacy of Agent Orange

CDC researchers analyzed data from 41 states for 145,811 adults with elevated BLLs from all causes, reported by the Adult Blood Lead Epidemiology and Surveillance program from 2003 to 2012. Of those reported cases, 349 had levels ≥ 80 µg/dL. RBF-associated cases accounted for 0.3% of adults with elevated BLLs, but 4.9% of adults with BLLs ≥ 80 µg/dL. The maximum recorded RBF-associated BLL was 306 µg/dL. Further, RBF-associated cases were “overrepresented” among people with BLLs ≥ 80 µg/dL: 3.7%, compared with 0.2% of people without RBF-related elevated lead levels.

As of 2004, the researchers say, < 100 cases of lead toxicity caused by RBFs had been reported in the medical literature. They advise asking any patient who has elevated BLLs with an unknown lead exposure source about RBFs. A low index of suspicion could delay diagnosis or even contribute to an incorrect diagnosis.

Related: Cutting Down on Dialysis-Related Infections

Moreover, BLLs can fluctuate in people with RBFs, they note. A patient with a low BLL at the time of testing can have an increase in BLL and become symptomatic when RBFs migrate, such as into a joint space. The CDC researchers suggest baseline and intermittent BLL tests for people with a history of RBFs.

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Paid Sick Days Help Reduce Flu Exposure (For Some)

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Wed, 08/22/2018 - 11:24
Cultural and structural workplace factors impact employees’ decisions to take sick time and prevent the spread of illness.

Research has confirmed what many people know from experience: that paid sick days can make the workplace healthier. In 1 study, researchers found universal access to paid sick days (PSD) reduced influenza in the workplace by 6%.  To drill down on the influence PSD access has on decisions to stay home from work, or to stay home with a child who has flu or influenza-like-illness, researchers from University of Pittsburgh analyzed data from the 2009 Medical Expenditure Panel Survey for 12,901 households and 12,044 employees. They chose the 2009 survey because the numbers of influenza-like-illness and influenza cases were likely to have been higher due to the 2009 H1N1 pandemic.

Of the workers surveyed, 64% had access to PSD. Access was associated significantly with gender, race/ethnicity, income, education, and number of employees in the workplace. In the group of 4,911 employees who had children, 68% had PSD.

The study highlighted some subgroups that face barriers to following CDC recommendations, such as staying home for up to 24 hours after symptoms subside. Hispanics, for instance, were significantly less likely to stay home when ill, but this was not necessarily an ethnic difference, the researchers say. Rather, they suggest, it may have had more to do with job security and workplace culture. They cite a survey done during the 2009 H1N1 pandemic, in which Hispanics reported fewer resources at work than non-Hispanic whites, including paid sick leave, job security, and ability to work from home.

Women tend to be the main caregivers for children. In this study, women had a higher prevalence of staying home for a child’s illness than men, even after the researchers controlled for PSD access. Yet, in a different survey women also were more likely to report for work when ill, or when a child was ill. The researchers called this “presenteeism.”

The researchers underscore the importance of PSD laws in reducing the economic burden of healthy behavior in families. They note that in 2015, 35% of employees did not have access to PSD, and those employees were usually people with low income. Only 34% of those in the lowest-income group had access to PSD, compared with 89% in the highest income groups.

 

Source:

Piper K, Youk A, James AE, III, Kumar S. PLoS ONE. 2017;12(2): e0170698.

doi:10.1371/journal.pone.0170698

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Cultural and structural workplace factors impact employees’ decisions to take sick time and prevent the spread of illness.
Cultural and structural workplace factors impact employees’ decisions to take sick time and prevent the spread of illness.

Research has confirmed what many people know from experience: that paid sick days can make the workplace healthier. In 1 study, researchers found universal access to paid sick days (PSD) reduced influenza in the workplace by 6%.  To drill down on the influence PSD access has on decisions to stay home from work, or to stay home with a child who has flu or influenza-like-illness, researchers from University of Pittsburgh analyzed data from the 2009 Medical Expenditure Panel Survey for 12,901 households and 12,044 employees. They chose the 2009 survey because the numbers of influenza-like-illness and influenza cases were likely to have been higher due to the 2009 H1N1 pandemic.

Of the workers surveyed, 64% had access to PSD. Access was associated significantly with gender, race/ethnicity, income, education, and number of employees in the workplace. In the group of 4,911 employees who had children, 68% had PSD.

The study highlighted some subgroups that face barriers to following CDC recommendations, such as staying home for up to 24 hours after symptoms subside. Hispanics, for instance, were significantly less likely to stay home when ill, but this was not necessarily an ethnic difference, the researchers say. Rather, they suggest, it may have had more to do with job security and workplace culture. They cite a survey done during the 2009 H1N1 pandemic, in which Hispanics reported fewer resources at work than non-Hispanic whites, including paid sick leave, job security, and ability to work from home.

Women tend to be the main caregivers for children. In this study, women had a higher prevalence of staying home for a child’s illness than men, even after the researchers controlled for PSD access. Yet, in a different survey women also were more likely to report for work when ill, or when a child was ill. The researchers called this “presenteeism.”

The researchers underscore the importance of PSD laws in reducing the economic burden of healthy behavior in families. They note that in 2015, 35% of employees did not have access to PSD, and those employees were usually people with low income. Only 34% of those in the lowest-income group had access to PSD, compared with 89% in the highest income groups.

 

Source:

Piper K, Youk A, James AE, III, Kumar S. PLoS ONE. 2017;12(2): e0170698.

doi:10.1371/journal.pone.0170698

Research has confirmed what many people know from experience: that paid sick days can make the workplace healthier. In 1 study, researchers found universal access to paid sick days (PSD) reduced influenza in the workplace by 6%.  To drill down on the influence PSD access has on decisions to stay home from work, or to stay home with a child who has flu or influenza-like-illness, researchers from University of Pittsburgh analyzed data from the 2009 Medical Expenditure Panel Survey for 12,901 households and 12,044 employees. They chose the 2009 survey because the numbers of influenza-like-illness and influenza cases were likely to have been higher due to the 2009 H1N1 pandemic.

Of the workers surveyed, 64% had access to PSD. Access was associated significantly with gender, race/ethnicity, income, education, and number of employees in the workplace. In the group of 4,911 employees who had children, 68% had PSD.

The study highlighted some subgroups that face barriers to following CDC recommendations, such as staying home for up to 24 hours after symptoms subside. Hispanics, for instance, were significantly less likely to stay home when ill, but this was not necessarily an ethnic difference, the researchers say. Rather, they suggest, it may have had more to do with job security and workplace culture. They cite a survey done during the 2009 H1N1 pandemic, in which Hispanics reported fewer resources at work than non-Hispanic whites, including paid sick leave, job security, and ability to work from home.

Women tend to be the main caregivers for children. In this study, women had a higher prevalence of staying home for a child’s illness than men, even after the researchers controlled for PSD access. Yet, in a different survey women also were more likely to report for work when ill, or when a child was ill. The researchers called this “presenteeism.”

The researchers underscore the importance of PSD laws in reducing the economic burden of healthy behavior in families. They note that in 2015, 35% of employees did not have access to PSD, and those employees were usually people with low income. Only 34% of those in the lowest-income group had access to PSD, compared with 89% in the highest income groups.

 

Source:

Piper K, Youk A, James AE, III, Kumar S. PLoS ONE. 2017;12(2): e0170698.

doi:10.1371/journal.pone.0170698

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Using Gel to Study Effects of Blasts on the Brain

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Researchers study a gel with florescent properties to replicate and understand the effects of a brain during an explosion.

A gel that mimics the texture and mass of the brain, developed by U.S. Army Research Laboratory scientists, may help reveal what happens to the brain during an explosion.

The researchers used pressure-sensitive nanomaterials. The fluorescence intensity of the gel increases or decreases with the amount of pressure applied. Based on how the nanoclusters fluoresce under each pressure, the researchers will be able to gauge what would happen in a “brain situation,” 1 of the researchers says in a Health.mil article. The researchers are planning to create a pressure scale to graph information about the effects of blast pressure from the changes in color.

The laboratory has a working relationship with Japanese medical researchers who are also studying the effects of blast waves. The Japanese team will test the U.S. Army’s samples with a laser-induced shockwave and share the results of that experiment with the U.S. Army.

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Researchers study a gel with florescent properties to replicate and understand the effects of a brain during an explosion.
Researchers study a gel with florescent properties to replicate and understand the effects of a brain during an explosion.

A gel that mimics the texture and mass of the brain, developed by U.S. Army Research Laboratory scientists, may help reveal what happens to the brain during an explosion.

The researchers used pressure-sensitive nanomaterials. The fluorescence intensity of the gel increases or decreases with the amount of pressure applied. Based on how the nanoclusters fluoresce under each pressure, the researchers will be able to gauge what would happen in a “brain situation,” 1 of the researchers says in a Health.mil article. The researchers are planning to create a pressure scale to graph information about the effects of blast pressure from the changes in color.

The laboratory has a working relationship with Japanese medical researchers who are also studying the effects of blast waves. The Japanese team will test the U.S. Army’s samples with a laser-induced shockwave and share the results of that experiment with the U.S. Army.

A gel that mimics the texture and mass of the brain, developed by U.S. Army Research Laboratory scientists, may help reveal what happens to the brain during an explosion.

The researchers used pressure-sensitive nanomaterials. The fluorescence intensity of the gel increases or decreases with the amount of pressure applied. Based on how the nanoclusters fluoresce under each pressure, the researchers will be able to gauge what would happen in a “brain situation,” 1 of the researchers says in a Health.mil article. The researchers are planning to create a pressure scale to graph information about the effects of blast pressure from the changes in color.

The laboratory has a working relationship with Japanese medical researchers who are also studying the effects of blast waves. The Japanese team will test the U.S. Army’s samples with a laser-induced shockwave and share the results of that experiment with the U.S. Army.

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NIOSH Guide Promotes Holistic View of Worker Health

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NIOSH provides a “user-friendly” resource to improve health, safety, and environment for workers in all places of employment.

Stress levels, access to sick leave (or lack thereof), hazardous conditions, and interactions with coworkers have a ripple effect on the lives of workers, their families, and their communities. A safe workplace that supports the well-being of workers can have far-reaching benefits. That’s the premise and promise of Fundamentals of Total Worker Health Approaches: Essential Elements for Advancing Worker Safety, Health, and Well-Being, created by the National Institute for Occupational Safety and Health (NIOSH).

The workbook provides a “user-friendly entry point” into total worker health with examples and tips, such as, “design programs with a long-term outlook to ensure sustainability. Short-term approaches have short-term value.” It also includes a self-assessment tool and resources to develop an action plan and measure progress specific to the organization. A new conceptual model—a “hierarchy of controls”—lists ways to minimize or eliminate exposure to hazards in the workplace, from least effective (eg, providing personal protective equipment) to most effective (eg, physically removing the hazard).

Each workplace is unique, NIOSH says, and because the experiences of people who manage and work in them differ, the workbook is not intended as a one-size-fits-all tool. But it can be used to provide a “snapshot” of where the organization is on the path to total worker health.

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NIOSH provides a “user-friendly” resource to improve health, safety, and environment for workers in all places of employment.
NIOSH provides a “user-friendly” resource to improve health, safety, and environment for workers in all places of employment.

Stress levels, access to sick leave (or lack thereof), hazardous conditions, and interactions with coworkers have a ripple effect on the lives of workers, their families, and their communities. A safe workplace that supports the well-being of workers can have far-reaching benefits. That’s the premise and promise of Fundamentals of Total Worker Health Approaches: Essential Elements for Advancing Worker Safety, Health, and Well-Being, created by the National Institute for Occupational Safety and Health (NIOSH).

The workbook provides a “user-friendly entry point” into total worker health with examples and tips, such as, “design programs with a long-term outlook to ensure sustainability. Short-term approaches have short-term value.” It also includes a self-assessment tool and resources to develop an action plan and measure progress specific to the organization. A new conceptual model—a “hierarchy of controls”—lists ways to minimize or eliminate exposure to hazards in the workplace, from least effective (eg, providing personal protective equipment) to most effective (eg, physically removing the hazard).

Each workplace is unique, NIOSH says, and because the experiences of people who manage and work in them differ, the workbook is not intended as a one-size-fits-all tool. But it can be used to provide a “snapshot” of where the organization is on the path to total worker health.

Stress levels, access to sick leave (or lack thereof), hazardous conditions, and interactions with coworkers have a ripple effect on the lives of workers, their families, and their communities. A safe workplace that supports the well-being of workers can have far-reaching benefits. That’s the premise and promise of Fundamentals of Total Worker Health Approaches: Essential Elements for Advancing Worker Safety, Health, and Well-Being, created by the National Institute for Occupational Safety and Health (NIOSH).

The workbook provides a “user-friendly entry point” into total worker health with examples and tips, such as, “design programs with a long-term outlook to ensure sustainability. Short-term approaches have short-term value.” It also includes a self-assessment tool and resources to develop an action plan and measure progress specific to the organization. A new conceptual model—a “hierarchy of controls”—lists ways to minimize or eliminate exposure to hazards in the workplace, from least effective (eg, providing personal protective equipment) to most effective (eg, physically removing the hazard).

Each workplace is unique, NIOSH says, and because the experiences of people who manage and work in them differ, the workbook is not intended as a one-size-fits-all tool. But it can be used to provide a “snapshot” of where the organization is on the path to total worker health.

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HHS Funds More Health Centers

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Wed, 03/27/2019 - 11:49
More than $50 million in funding will be awarded to HRSA (Health Resources and Services Administration) -funded health centers to continue and extend care to more than 24 million patients.

The HHS has announced more than $50 million in funding for 75 health centers in 23 states, Puerto Rico, and the Federated States of Micronesia.

One in 13 people nationwide depend on a Health Resources and Services Administration (HRSA)-funded health center for preventive and primary health care needs. Among the special populations served are nearly 2 million homeless patients, 910,172 agricultural workers, and 305,520 veterans.

Health centers are community based and patient directed, delivering comprehensive, culturally competent primary care. They also often link to pharmacy, mental health, substance abuse, and oral health services in areas where economic, geographic, or cultural barriers limit access to affordable health care services.

Although the health centers serve patients who are often sicker and more at risk than is the general population, the quality of care “equals and often surpasses” that provided by other primary care providers, HRSA says. For example, > 93% of HRSA-funded health centers met or exceeded at least 1 goal of Healthy People 2020 for clinical performance in 2015. And > 68% of health centers are recognized by national accrediting organizations as Patient-Centered Medical Homes, an advanced model of team-based primary care.

The health centers, which started 50 years ago with just 2, have expanded to > 9,800 clinic sites. Between 2008 -2015, HRSA-supported centers increased by 27%, and the number of patients increased by 42% to more than 7 million more patients. In 2015 alone, HRSA funded nearly 430 new center sites. Health centers already provide care to  more than 24 million people; this new funding will extend care to about 240,000 additional patients.

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More than $50 million in funding will be awarded to HRSA (Health Resources and Services Administration) -funded health centers to continue and extend care to more than 24 million patients.
More than $50 million in funding will be awarded to HRSA (Health Resources and Services Administration) -funded health centers to continue and extend care to more than 24 million patients.

The HHS has announced more than $50 million in funding for 75 health centers in 23 states, Puerto Rico, and the Federated States of Micronesia.

One in 13 people nationwide depend on a Health Resources and Services Administration (HRSA)-funded health center for preventive and primary health care needs. Among the special populations served are nearly 2 million homeless patients, 910,172 agricultural workers, and 305,520 veterans.

Health centers are community based and patient directed, delivering comprehensive, culturally competent primary care. They also often link to pharmacy, mental health, substance abuse, and oral health services in areas where economic, geographic, or cultural barriers limit access to affordable health care services.

Although the health centers serve patients who are often sicker and more at risk than is the general population, the quality of care “equals and often surpasses” that provided by other primary care providers, HRSA says. For example, > 93% of HRSA-funded health centers met or exceeded at least 1 goal of Healthy People 2020 for clinical performance in 2015. And > 68% of health centers are recognized by national accrediting organizations as Patient-Centered Medical Homes, an advanced model of team-based primary care.

The health centers, which started 50 years ago with just 2, have expanded to > 9,800 clinic sites. Between 2008 -2015, HRSA-supported centers increased by 27%, and the number of patients increased by 42% to more than 7 million more patients. In 2015 alone, HRSA funded nearly 430 new center sites. Health centers already provide care to  more than 24 million people; this new funding will extend care to about 240,000 additional patients.

The HHS has announced more than $50 million in funding for 75 health centers in 23 states, Puerto Rico, and the Federated States of Micronesia.

One in 13 people nationwide depend on a Health Resources and Services Administration (HRSA)-funded health center for preventive and primary health care needs. Among the special populations served are nearly 2 million homeless patients, 910,172 agricultural workers, and 305,520 veterans.

Health centers are community based and patient directed, delivering comprehensive, culturally competent primary care. They also often link to pharmacy, mental health, substance abuse, and oral health services in areas where economic, geographic, or cultural barriers limit access to affordable health care services.

Although the health centers serve patients who are often sicker and more at risk than is the general population, the quality of care “equals and often surpasses” that provided by other primary care providers, HRSA says. For example, > 93% of HRSA-funded health centers met or exceeded at least 1 goal of Healthy People 2020 for clinical performance in 2015. And > 68% of health centers are recognized by national accrediting organizations as Patient-Centered Medical Homes, an advanced model of team-based primary care.

The health centers, which started 50 years ago with just 2, have expanded to > 9,800 clinic sites. Between 2008 -2015, HRSA-supported centers increased by 27%, and the number of patients increased by 42% to more than 7 million more patients. In 2015 alone, HRSA funded nearly 430 new center sites. Health centers already provide care to  more than 24 million people; this new funding will extend care to about 240,000 additional patients.

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