M. Alexander Otto began his reporting career early in 1999 covering the pharmaceutical industry for a national pharmacists' magazine and freelancing for the Washington Post and other newspapers. He then joined BNA, now part of Bloomberg News, covering health law and the protection of people and animals in medical research. Alex next worked for the McClatchy Company. Based on his work, Alex won a year-long Knight Science Journalism Fellowship to MIT in 2008-2009. He joined the company shortly thereafter. Alex has a newspaper journalism degree from Syracuse (N.Y.) University and a master's degree in medical science -- a physician assistant degree -- from George Washington University. Alex is based in Seattle.
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Survival benefit with nivolumab extends to 5 years in NSCLC
Early response portends durable outcome, but the optimal duration of treatment is uncertain.
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Cell-free DNA improves response prediction in breast cancer
Using cell-free DNA and MRI in combination improved prediction of pathological complete response.
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Combo provides ‘broad benefit’ across NHL subtypes
Adding copanlisib to rituximab improved progression-free survival, but overall survival data are not mature.
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Endometrial thickness could predict cancer, guide lymph node assessment
Patients with endometrial intraepithelial neoplasia don’t need routine lymph node sampling, an investigator says.
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Negative results when immunotherapy was added to chemoradiotherapy
A phase 3 trial investigating the addition of avelumab to chemoradiotherapy in patients with head and neck cancer was stopped early.
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Technique combines ‘best of both worlds’ to target lung nodules
Bronchoscopic transbronchial microwave ablation proved feasible in a small study.
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Study supports lower starting dose of lenvatinib for endometrial cancer
A 14-mg dose was safer and just as effective as a 20-mg dose in a retrospective study.
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Cytoreduction in advanced ovarian cancer: ‘Keep the status quo’
Debulking surgery should be considered whenever feasible, according to researchers.
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Melatonin not recommended for early-stage NSCLC
There was a hint of benefit with melatonin among patients with stage III/IV NSCLC.
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Delaying surgery didn’t impact survival in early-stage cervical cancer
The results are “reassuring” in light of the pandemic, according to an investigator.
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Expert recommendations for targeted therapies in advanced NSCLC
The recommendations update guidance from 2017.
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Ovarian cancer prevention: How patients decide on surgery
Twenty-four women reveal how they made a difficult decision.