Metastatic melanoma masquerading as disseminated sporotrichosis

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Fri, 01/04/2019 - 11:10

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The incidence of melanoma in the United States has increased between 1975 and 2010 with an estimated 76,100 new cases in 2014.¹ While reasons behind this are controversial, increased recreational exposure to ultraviolet radiation is believed to be an important factor.² Although most patients present at an early stage, some present with metastatic disease. The clinical presentation of metastatic melanoma is variable and depends on disease site, burden, and systemic effects. Diffuse melanosis is a rare manifestation of metastatic melanoma that is characterized by diffuse slate-gray discoloration of the skin and mucous membranes as a result of pigment deposition and is associated with poor prognosis.³ Here, we present a rare case of metastatic melanoma with diffuse melanosis that was initially diagnosed as disseminated sporotrichosis based on a false-positive serologic test and discuss the possible mechanism behind this observation.

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Article PDF

JCSO_Sep_2014_339_Khalil.pdf

Issue

The Journal of Community and Supportive Oncology - 12(9)

Publications

The Journal of Community and Supportive Oncology

MDedge Hematology and Oncology

Topics

Melanoma

Page Number

339-340

Legacy Keywords

metastatic melanoma, disseminated sporotrichosis, diffuse melanosis, Sporothrix schenckii

Sections

Case Reports

Author(s)

Mohammed Muqeet Adnan et al

Author(s)

Mohammed Muqeet Adnan et al

Article PDF

JCSO_Sep_2014_339_Khalil.pdf

Article PDF

JCSO_Sep_2014_339_Khalil.pdf

The incidence of melanoma in the United States has increased between 1975 and 2010 with an estimated 76,100 new cases in 2014.¹ While reasons behind this are controversial, increased recreational exposure to ultraviolet radiation is believed to be an important factor.² Although most patients present at an early stage, some present with metastatic disease. The clinical presentation of metastatic melanoma is variable and depends on disease site, burden, and systemic effects. Diffuse melanosis is a rare manifestation of metastatic melanoma that is characterized by diffuse slate-gray discoloration of the skin and mucous membranes as a result of pigment deposition and is associated with poor prognosis.³ Here, we present a rare case of metastatic melanoma with diffuse melanosis that was initially diagnosed as disseminated sporotrichosis based on a false-positive serologic test and discuss the possible mechanism behind this observation.

Click on the PDF icon at the top of this introduction to read the full article.

The incidence of melanoma in the United States has increased between 1975 and 2010 with an estimated 76,100 new cases in 2014.¹ While reasons behind this are controversial, increased recreational exposure to ultraviolet radiation is believed to be an important factor.² Although most patients present at an early stage, some present with metastatic disease. The clinical presentation of metastatic melanoma is variable and depends on disease site, burden, and systemic effects. Diffuse melanosis is a rare manifestation of metastatic melanoma that is characterized by diffuse slate-gray discoloration of the skin and mucous membranes as a result of pigment deposition and is associated with poor prognosis.³ Here, we present a rare case of metastatic melanoma with diffuse melanosis that was initially diagnosed as disseminated sporotrichosis based on a false-positive serologic test and discuss the possible mechanism behind this observation.

Click on the PDF icon at the top of this introduction to read the full article.

Issue

The Journal of Community and Supportive Oncology - 12(9)

Issue

The Journal of Community and Supportive Oncology - 12(9)

Page Number

339-340

Page Number

339-340

Publications

The Journal of Community and Supportive Oncology

MDedge Hematology and Oncology