Key clinical point: Patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) during their first complete remission (CR) from a mismatched unrelated donor (MMUD), umbilical cord blood (UCB), or a haploidentical-related donor (Haplo) had similar outcomes, making all of them a viable option in the absence of a matched related or unrelated donor.

Major finding: For patients who had transplants between 2015 and 2018, the 3-year overall survival of MMUD, UCB, and Haplo groups were 60%, 66%, and 63%, respectively (P = .693). The rates of nonrelapse mortality (P = .147), relapse (P = .075), and graft-versus-host disease-free/relapse-free survival (P = .365) were also similar between the 3 groups.

Study details: Findings are from a retrospective analysis of 1,932 patients with AML who underwent allo-HSCT during their first CR from MMUD, UCB or Haplo.

Disclosures: This study was supported by grants from the Practical Research Project for Allergic Diseases and Immunology from the Japan Agency for Medical Research and Development and the Aichi Cancer Research Foundation. The authors declared no conflicts of interest.

Source: Yanada M et al. Transplant Cell Ther. 2021 Sep 6. doi: 10.1016/j.jtct.2021.08.027.

Key clinical point: Patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) during their first complete remission (CR) from a mismatched unrelated donor (MMUD), umbilical cord blood (UCB), or a haploidentical-related donor (Haplo) had similar outcomes, making all of them a viable option in the absence of a matched related or unrelated donor.

Major finding: For patients who had transplants between 2015 and 2018, the 3-year overall survival of MMUD, UCB, and Haplo groups were 60%, 66%, and 63%, respectively (P = .693). The rates of nonrelapse mortality (P = .147), relapse (P = .075), and graft-versus-host disease-free/relapse-free survival (P = .365) were also similar between the 3 groups.

Study details: Findings are from a retrospective analysis of 1,932 patients with AML who underwent allo-HSCT during their first CR from MMUD, UCB or Haplo.

Disclosures: This study was supported by grants from the Practical Research Project for Allergic Diseases and Immunology from the Japan Agency for Medical Research and Development and the Aichi Cancer Research Foundation. The authors declared no conflicts of interest.

Source: Yanada M et al. Transplant Cell Ther. 2021 Sep 6. doi: 10.1016/j.jtct.2021.08.027.

Key clinical point: Patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) during their first complete remission (CR) from a mismatched unrelated donor (MMUD), umbilical cord blood (UCB), or a haploidentical-related donor (Haplo) had similar outcomes, making all of them a viable option in the absence of a matched related or unrelated donor.

Major finding: For patients who had transplants between 2015 and 2018, the 3-year overall survival of MMUD, UCB, and Haplo groups were 60%, 66%, and 63%, respectively (P = .693). The rates of nonrelapse mortality (P = .147), relapse (P = .075), and graft-versus-host disease-free/relapse-free survival (P = .365) were also similar between the 3 groups.

Study details: Findings are from a retrospective analysis of 1,932 patients with AML who underwent allo-HSCT during their first CR from MMUD, UCB or Haplo.

Disclosures: This study was supported by grants from the Practical Research Project for Allergic Diseases and Immunology from the Japan Agency for Medical Research and Development and the Aichi Cancer Research Foundation. The authors declared no conflicts of interest.

Source: Yanada M et al. Transplant Cell Ther. 2021 Sep 6. doi: 10.1016/j.jtct.2021.08.027.

Key clinical point: De-escalation of cytarabine exposure by elimination of the fifth chemotherapy course should only be considered in pediatric patients with low-risk acute myeloid leukemia (LR-AML) with favorable cytogenetic/molecular features and negative minimal residual disease (MRD) at the end of first induction (EOI1).

Major finding: Overall, patients who received 4 vs. 5 chemotherapy courses had worse disease-free survival (DFS; hazard ratio [HR] 1.45; P = .009) and relapse risk (HR 1.40; P = .019). However, patients with favorable cytogenetic/molecular features and negative MRD at EOI1 had no difference in DFS (P = .934) and overall survival (P = .928) with 4 vs. 5 chemotherapy courses.

Study details: This prospective study assessed 923 pediatric patients with LR-AML treated in either AAML0531 (n = 225; excluding those treated with gemtuzumab ozogamicin) or AAML1031 (n = 698) trials with 4 (79%) or 5 (21%) courses of frontline chemotherapy.

Disclosures: This study was supported by National Clinical Trials Network (NCTN) Operations Center, NCTN Statistics & Data Center, St. Baldrick’s Foundation, Alex’s Lemonade Stand Foundation, and National Heart Lung and Blood Institute. The authors declared no conflicts of interest.

Source: Getz KD et al. Pediatr Blood Cancer. 2021 Sep 2. doi: 10.1002/pbc.29313.

Key clinical point: De-escalation of cytarabine exposure by elimination of the fifth chemotherapy course should only be considered in pediatric patients with low-risk acute myeloid leukemia (LR-AML) with favorable cytogenetic/molecular features and negative minimal residual disease (MRD) at the end of first induction (EOI1).

Major finding: Overall, patients who received 4 vs. 5 chemotherapy courses had worse disease-free survival (DFS; hazard ratio [HR] 1.45; P = .009) and relapse risk (HR 1.40; P = .019). However, patients with favorable cytogenetic/molecular features and negative MRD at EOI1 had no difference in DFS (P = .934) and overall survival (P = .928) with 4 vs. 5 chemotherapy courses.

Study details: This prospective study assessed 923 pediatric patients with LR-AML treated in either AAML0531 (n = 225; excluding those treated with gemtuzumab ozogamicin) or AAML1031 (n = 698) trials with 4 (79%) or 5 (21%) courses of frontline chemotherapy.

Disclosures: This study was supported by National Clinical Trials Network (NCTN) Operations Center, NCTN Statistics & Data Center, St. Baldrick’s Foundation, Alex’s Lemonade Stand Foundation, and National Heart Lung and Blood Institute. The authors declared no conflicts of interest.

Source: Getz KD et al. Pediatr Blood Cancer. 2021 Sep 2. doi: 10.1002/pbc.29313.

Key clinical point: De-escalation of cytarabine exposure by elimination of the fifth chemotherapy course should only be considered in pediatric patients with low-risk acute myeloid leukemia (LR-AML) with favorable cytogenetic/molecular features and negative minimal residual disease (MRD) at the end of first induction (EOI1).

Major finding: Overall, patients who received 4 vs. 5 chemotherapy courses had worse disease-free survival (DFS; hazard ratio [HR] 1.45; P = .009) and relapse risk (HR 1.40; P = .019). However, patients with favorable cytogenetic/molecular features and negative MRD at EOI1 had no difference in DFS (P = .934) and overall survival (P = .928) with 4 vs. 5 chemotherapy courses.

Study details: This prospective study assessed 923 pediatric patients with LR-AML treated in either AAML0531 (n = 225; excluding those treated with gemtuzumab ozogamicin) or AAML1031 (n = 698) trials with 4 (79%) or 5 (21%) courses of frontline chemotherapy.

Disclosures: This study was supported by National Clinical Trials Network (NCTN) Operations Center, NCTN Statistics & Data Center, St. Baldrick’s Foundation, Alex’s Lemonade Stand Foundation, and National Heart Lung and Blood Institute. The authors declared no conflicts of interest.

Source: Getz KD et al. Pediatr Blood Cancer. 2021 Sep 2. doi: 10.1002/pbc.29313.

Key clinical point: Mutations of the CCAAT/enhancer-binding protein alpha gene (CEBPA) in the basic leucine zipper domain (bZIP), even when detected as single-mutated CEBPA, were associated with favorable prognosis in patients with de novo acute myeloid leukemia (AML).

Major finding: Patients with compared to without CEBPA mutation in bZIP had a higher rate of complete remission, longer overall survival (OS), and lower cumulative incidence of relapse (all P < .001). Among patients with single-mutated CEBPA, those with CEBPA mutation in compared to out-of bZIP had a significantly longer OS (P = .008).

Study details: Findings are from a retrospective analysis of 1,028 patients with de novo AML.

Disclosures: No source of funding was identified. The authors declared no conflict of interests.

Source: Wakita S et al. Blood Adv. 2021 Aug 27. doi: 10.1182/bloodadvances.2021004292.

Key clinical point: Mutations of the CCAAT/enhancer-binding protein alpha gene (CEBPA) in the basic leucine zipper domain (bZIP), even when detected as single-mutated CEBPA, were associated with favorable prognosis in patients with de novo acute myeloid leukemia (AML).

Major finding: Patients with compared to without CEBPA mutation in bZIP had a higher rate of complete remission, longer overall survival (OS), and lower cumulative incidence of relapse (all P < .001). Among patients with single-mutated CEBPA, those with CEBPA mutation in compared to out-of bZIP had a significantly longer OS (P = .008).

Study details: Findings are from a retrospective analysis of 1,028 patients with de novo AML.

Disclosures: No source of funding was identified. The authors declared no conflict of interests.

Source: Wakita S et al. Blood Adv. 2021 Aug 27. doi: 10.1182/bloodadvances.2021004292.

Key clinical point: Mutations of the CCAAT/enhancer-binding protein alpha gene (CEBPA) in the basic leucine zipper domain (bZIP), even when detected as single-mutated CEBPA, were associated with favorable prognosis in patients with de novo acute myeloid leukemia (AML).

Major finding: Patients with compared to without CEBPA mutation in bZIP had a higher rate of complete remission, longer overall survival (OS), and lower cumulative incidence of relapse (all P < .001). Among patients with single-mutated CEBPA, those with CEBPA mutation in compared to out-of bZIP had a significantly longer OS (P = .008).

Study details: Findings are from a retrospective analysis of 1,028 patients with de novo AML.

Disclosures: No source of funding was identified. The authors declared no conflict of interests.

Source: Wakita S et al. Blood Adv. 2021 Aug 27. doi: 10.1182/bloodadvances.2021004292.

Key clinical point: Oral azacitidine (OA) maintenance had a manageable safety profile in patients with newly diagnosed acute myeloid leukemia (AML) who attained the first complete remission (CR) or CR with incomplete blood count recovery (CRi) after induction chemotherapy (IC). However, blood count monitoring for at least the first 2 treatment cycles is recommended.

Major finding: Gastrointestinal (91% vs. 62%) and hematologic (66% vs. 47%) adverse events were common with OA vs. placebo. Adverse events were mostly manageable with dose interruptions (43%) or reductions (16%) and infrequently led to OA discontinuation (13%).

Study details: This safety analysis of the QUAZAR AML-001 trial included 469 patients with newly diagnosed AML with intermediate- or poor-risk cytogenetics who attained the first CR/CRi after IC, randomly assigned to receive either 300 mg OA (n = 236) or placebo (n = 233).

Disclosures: This study was funded by Celgene, a Bristol Myers Squibb Company. Some investigators, including the lead author, reported ties with various pharmaceutical companies including Celgene and Bristol Myers Squibb.

Source: Ravandi F et al. J Hematol Oncol. 2021 Aug 28. doi: 10.1186/s13045-021-01142-x.

Key clinical point: Oral azacitidine (OA) maintenance had a manageable safety profile in patients with newly diagnosed acute myeloid leukemia (AML) who attained the first complete remission (CR) or CR with incomplete blood count recovery (CRi) after induction chemotherapy (IC). However, blood count monitoring for at least the first 2 treatment cycles is recommended.

Major finding: Gastrointestinal (91% vs. 62%) and hematologic (66% vs. 47%) adverse events were common with OA vs. placebo. Adverse events were mostly manageable with dose interruptions (43%) or reductions (16%) and infrequently led to OA discontinuation (13%).

Study details: This safety analysis of the QUAZAR AML-001 trial included 469 patients with newly diagnosed AML with intermediate- or poor-risk cytogenetics who attained the first CR/CRi after IC, randomly assigned to receive either 300 mg OA (n = 236) or placebo (n = 233).

Disclosures: This study was funded by Celgene, a Bristol Myers Squibb Company. Some investigators, including the lead author, reported ties with various pharmaceutical companies including Celgene and Bristol Myers Squibb.

Source: Ravandi F et al. J Hematol Oncol. 2021 Aug 28. doi: 10.1186/s13045-021-01142-x.

Key clinical point: Oral azacitidine (OA) maintenance had a manageable safety profile in patients with newly diagnosed acute myeloid leukemia (AML) who attained the first complete remission (CR) or CR with incomplete blood count recovery (CRi) after induction chemotherapy (IC). However, blood count monitoring for at least the first 2 treatment cycles is recommended.

Major finding: Gastrointestinal (91% vs. 62%) and hematologic (66% vs. 47%) adverse events were common with OA vs. placebo. Adverse events were mostly manageable with dose interruptions (43%) or reductions (16%) and infrequently led to OA discontinuation (13%).

Study details: This safety analysis of the QUAZAR AML-001 trial included 469 patients with newly diagnosed AML with intermediate- or poor-risk cytogenetics who attained the first CR/CRi after IC, randomly assigned to receive either 300 mg OA (n = 236) or placebo (n = 233).

Disclosures: This study was funded by Celgene, a Bristol Myers Squibb Company. Some investigators, including the lead author, reported ties with various pharmaceutical companies including Celgene and Bristol Myers Squibb.

Source: Ravandi F et al. J Hematol Oncol. 2021 Aug 28. doi: 10.1186/s13045-021-01142-x.

Key clinical point: Low-intensity treatment with low-dose cytarabine (LD-AC) combined with cladribine offered therapeutic benefit with an acceptable safety profile in elderly patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.

Major finding: Rates of overall response and 56-day mortality were 54.0% and 20.5%, respectively. The median overall survival was 6.9 months (95% CI 4.9-9.6) and superior in patients who achieved an objective response (hazard ratio [HR] 0.04; P < .0001) or partial remission (HR 0.31; P = .0002) compared to nonresponders.

Study details: Findings are from a prospective analysis of 117 elderly patients (age, 60 years or older) with AML with poor performance status or a high comorbidity index treated with frontline LD-AC and cladribine.

Disclosures: This study was supported by the Institute of Hematology and Transfusion Medicine in Warsaw and Polish Adult Leukemia Group. The authors declared no conflicts of interest.

Source: Budziszewska BK et al. Cancers. 2021 Aug 20. doi: 10.3390/cancers13164189.

Key clinical point: Low-intensity treatment with low-dose cytarabine (LD-AC) combined with cladribine offered therapeutic benefit with an acceptable safety profile in elderly patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.

Major finding: Rates of overall response and 56-day mortality were 54.0% and 20.5%, respectively. The median overall survival was 6.9 months (95% CI 4.9-9.6) and superior in patients who achieved an objective response (hazard ratio [HR] 0.04; P < .0001) or partial remission (HR 0.31; P = .0002) compared to nonresponders.

Study details: Findings are from a prospective analysis of 117 elderly patients (age, 60 years or older) with AML with poor performance status or a high comorbidity index treated with frontline LD-AC and cladribine.

Disclosures: This study was supported by the Institute of Hematology and Transfusion Medicine in Warsaw and Polish Adult Leukemia Group. The authors declared no conflicts of interest.

Source: Budziszewska BK et al. Cancers. 2021 Aug 20. doi: 10.3390/cancers13164189.

Key clinical point: Low-intensity treatment with low-dose cytarabine (LD-AC) combined with cladribine offered therapeutic benefit with an acceptable safety profile in elderly patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.

Major finding: Rates of overall response and 56-day mortality were 54.0% and 20.5%, respectively. The median overall survival was 6.9 months (95% CI 4.9-9.6) and superior in patients who achieved an objective response (hazard ratio [HR] 0.04; P < .0001) or partial remission (HR 0.31; P = .0002) compared to nonresponders.

Study details: Findings are from a prospective analysis of 117 elderly patients (age, 60 years or older) with AML with poor performance status or a high comorbidity index treated with frontline LD-AC and cladribine.

Disclosures: This study was supported by the Institute of Hematology and Transfusion Medicine in Warsaw and Polish Adult Leukemia Group. The authors declared no conflicts of interest.

Source: Budziszewska BK et al. Cancers. 2021 Aug 20. doi: 10.3390/cancers13164189.

Key clinical point: Gemtuzumab ozogamicin (GO) showed superior survival outcomes in patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) than non-GO therapy, but higher dose increased the risk for early death.

Major finding: GO vs. non-GO arm showed improved overall survival (hazard ratio [HR], 0.86; P = .003), event-free survival (HR, 0.86; P = .015), and relapse-free survival (HR, 0.83; P = .001). However, GO vs. non-GO was associated with an increased risk for early death at a dose of 6 mg/m² or higher (relative risk [RR] 2.01; P = .005), hepatic-related adverse effects (RR 1.29; P = .02), and bleeding (RR 1.13; P = .018).

Study details: Findings are from a meta-analysis of 15 randomized controlled trials and 15 retrospective studies that compared GO (n = 4,768) with non-GO (n = 6,466) therapies in 11,234 patients with AML (n = 11,105) and high-risk MDS (n = 129).

Disclosures: This study was supported by the Chinese National Major Project for New Drug Innovation, the National Natural Science Foundation of China, Shenzhen Science and Technology Foundation, and Shenzhen Key Laboratory Foundation. The authors declared no conflicts of interest.

Source: Xu Q et al. Front Immunol. 2021 Aug 16. doi: 10.3389/fimmu.2021.683595.

Key clinical point: Gemtuzumab ozogamicin (GO) showed superior survival outcomes in patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) than non-GO therapy, but higher dose increased the risk for early death.

Major finding: GO vs. non-GO arm showed improved overall survival (hazard ratio [HR], 0.86; P = .003), event-free survival (HR, 0.86; P = .015), and relapse-free survival (HR, 0.83; P = .001). However, GO vs. non-GO was associated with an increased risk for early death at a dose of 6 mg/m² or higher (relative risk [RR] 2.01; P = .005), hepatic-related adverse effects (RR 1.29; P = .02), and bleeding (RR 1.13; P = .018).

Study details: Findings are from a meta-analysis of 15 randomized controlled trials and 15 retrospective studies that compared GO (n = 4,768) with non-GO (n = 6,466) therapies in 11,234 patients with AML (n = 11,105) and high-risk MDS (n = 129).

Disclosures: This study was supported by the Chinese National Major Project for New Drug Innovation, the National Natural Science Foundation of China, Shenzhen Science and Technology Foundation, and Shenzhen Key Laboratory Foundation. The authors declared no conflicts of interest.

Source: Xu Q et al. Front Immunol. 2021 Aug 16. doi: 10.3389/fimmu.2021.683595.

Key clinical point: Gemtuzumab ozogamicin (GO) showed superior survival outcomes in patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) than non-GO therapy, but higher dose increased the risk for early death.

Major finding: GO vs. non-GO arm showed improved overall survival (hazard ratio [HR], 0.86; P = .003), event-free survival (HR, 0.86; P = .015), and relapse-free survival (HR, 0.83; P = .001). However, GO vs. non-GO was associated with an increased risk for early death at a dose of 6 mg/m² or higher (relative risk [RR] 2.01; P = .005), hepatic-related adverse effects (RR 1.29; P = .02), and bleeding (RR 1.13; P = .018).

Study details: Findings are from a meta-analysis of 15 randomized controlled trials and 15 retrospective studies that compared GO (n = 4,768) with non-GO (n = 6,466) therapies in 11,234 patients with AML (n = 11,105) and high-risk MDS (n = 129).

Disclosures: This study was supported by the Chinese National Major Project for New Drug Innovation, the National Natural Science Foundation of China, Shenzhen Science and Technology Foundation, and Shenzhen Key Laboratory Foundation. The authors declared no conflicts of interest.

Source: Xu Q et al. Front Immunol. 2021 Aug 16. doi: 10.3389/fimmu.2021.683595.

Key clinical point: Enasidenib was associated with superior overall survival (OS) compared to standard of care (SoC) therapies in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) with an isocitrate dehydrogenase 2 (IDH2) mutation who were ineligible for hematopoietic stem cell transplantation (HSCT).

Major finding: Enasidenib vs. SoC was associated with a significantly longer OS (hazard ratio 0.67; 95% CI 0.47-0.97).

Study details: Findings are from a propensity score-matching analysis including adult patients with R/R AML with an IDH2 mutation ineligible for HSCT treated with enasidenib (n=195) from the AG221 C-001 trial or SoC therapies (n=78) from the French Chart Review study.

Disclosures: This study was sponsored and funded by Bristol Myers Squibb Some investigators, including the lead author, reported ties with various pharmaceutical companies, including Bristol Myers Squibb.

Source: de Botton S et al. Cancer Med. 2021 Aug 24. doi: 10.1002/cam4.4182.

Key clinical point: Enasidenib was associated with superior overall survival (OS) compared to standard of care (SoC) therapies in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) with an isocitrate dehydrogenase 2 (IDH2) mutation who were ineligible for hematopoietic stem cell transplantation (HSCT).

Major finding: Enasidenib vs. SoC was associated with a significantly longer OS (hazard ratio 0.67; 95% CI 0.47-0.97).

Study details: Findings are from a propensity score-matching analysis including adult patients with R/R AML with an IDH2 mutation ineligible for HSCT treated with enasidenib (n=195) from the AG221 C-001 trial or SoC therapies (n=78) from the French Chart Review study.

Disclosures: This study was sponsored and funded by Bristol Myers Squibb Some investigators, including the lead author, reported ties with various pharmaceutical companies, including Bristol Myers Squibb.

Source: de Botton S et al. Cancer Med. 2021 Aug 24. doi: 10.1002/cam4.4182.

Key clinical point: Enasidenib was associated with superior overall survival (OS) compared to standard of care (SoC) therapies in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) with an isocitrate dehydrogenase 2 (IDH2) mutation who were ineligible for hematopoietic stem cell transplantation (HSCT).

Major finding: Enasidenib vs. SoC was associated with a significantly longer OS (hazard ratio 0.67; 95% CI 0.47-0.97).

Study details: Findings are from a propensity score-matching analysis including adult patients with R/R AML with an IDH2 mutation ineligible for HSCT treated with enasidenib (n=195) from the AG221 C-001 trial or SoC therapies (n=78) from the French Chart Review study.

Disclosures: This study was sponsored and funded by Bristol Myers Squibb Some investigators, including the lead author, reported ties with various pharmaceutical companies, including Bristol Myers Squibb.

Source: de Botton S et al. Cancer Med. 2021 Aug 24. doi: 10.1002/cam4.4182.

Key clinical point: The administration of decitabine in alternating cycles with sapacitabine vs. decitabine monotherapy did not significantly improve outcomes in older patients with newly diagnosed acute myeloid leukemia (AML) who were unfit or chose not to receive intensive induction chemotherapy.

Major finding: The median overall survival (5.9 months vs. 5.7 months; P = .8902) and rates of complete remission (16.6% vs. 10.8%; P = .1468) were not significantly different in patients receiving decitabine plus sapacitabine vs. decitabine monotherapy.

Study details: Findings are from the phase 3 SEAMLESS trial including 482 elderly patients (age, 70 years or older) with newly diagnosed AML unsuitable or unwilling for intensive induction chemotherapy. Patients were randomly assigned to receive either decitabine in alternating cycles with sapacitabine or decitabine monotherapy.

Disclosures: This study was sponsored by Cyclacel Limited (Dundee, Scotland, United Kingdom). The lead author reported research grants and honoraria from various sources. Other authors reported ties with various pharmaceutical companies including Cyclacel.

Source: Kantarjian HM et al. Cancer. 2021 Aug 23. doi: 10.1002/cncr.33828.

Key clinical point: The administration of decitabine in alternating cycles with sapacitabine vs. decitabine monotherapy did not significantly improve outcomes in older patients with newly diagnosed acute myeloid leukemia (AML) who were unfit or chose not to receive intensive induction chemotherapy.

Major finding: The median overall survival (5.9 months vs. 5.7 months; P = .8902) and rates of complete remission (16.6% vs. 10.8%; P = .1468) were not significantly different in patients receiving decitabine plus sapacitabine vs. decitabine monotherapy.

Study details: Findings are from the phase 3 SEAMLESS trial including 482 elderly patients (age, 70 years or older) with newly diagnosed AML unsuitable or unwilling for intensive induction chemotherapy. Patients were randomly assigned to receive either decitabine in alternating cycles with sapacitabine or decitabine monotherapy.

Disclosures: This study was sponsored by Cyclacel Limited (Dundee, Scotland, United Kingdom). The lead author reported research grants and honoraria from various sources. Other authors reported ties with various pharmaceutical companies including Cyclacel.

Source: Kantarjian HM et al. Cancer. 2021 Aug 23. doi: 10.1002/cncr.33828.

Key clinical point: The administration of decitabine in alternating cycles with sapacitabine vs. decitabine monotherapy did not significantly improve outcomes in older patients with newly diagnosed acute myeloid leukemia (AML) who were unfit or chose not to receive intensive induction chemotherapy.

Major finding: The median overall survival (5.9 months vs. 5.7 months; P = .8902) and rates of complete remission (16.6% vs. 10.8%; P = .1468) were not significantly different in patients receiving decitabine plus sapacitabine vs. decitabine monotherapy.

Study details: Findings are from the phase 3 SEAMLESS trial including 482 elderly patients (age, 70 years or older) with newly diagnosed AML unsuitable or unwilling for intensive induction chemotherapy. Patients were randomly assigned to receive either decitabine in alternating cycles with sapacitabine or decitabine monotherapy.

Disclosures: This study was sponsored by Cyclacel Limited (Dundee, Scotland, United Kingdom). The lead author reported research grants and honoraria from various sources. Other authors reported ties with various pharmaceutical companies including Cyclacel.

Source: Kantarjian HM et al. Cancer. 2021 Aug 23. doi: 10.1002/cncr.33828.

Key clinical point: Patients with psoriatic arthritis (PsA) performed poorly in all dimensions of the European Quality of Life (EQ-5D) scoring of quality of life (QoL) as compared with the general population, thus reflecting the detrimental effect of PsA on QoL.

Major finding: Overall, 87.3% and 69.8% of patients with PsA experienced pain/discomfort and anxiety/depression, respectively. Patients with PsA presented worse results in all dimensions of the EQ-5D scale and had a lower mean QoL score compared to the general population (0.651 vs. 0.793; P < .001) with worsened QoL in patients with concomitant use of nonsteroidal anti-inflammatory drugs (P = .035) and comorbidities (P = .003).

Study details: Findings are from a cross-sectional study including 212 adult patients with PsA from a single-center pharmacy in Minas Gerais, Brazil.

Disclosures: This study was supported by Minas Gerais Research Support Foundation and National Council for Scientific and Technological Development. Several of the authors declared receiving educational scholarships, grants, or personal fees from several sources.

Source: Moraes FA et al. Value Health Reg Issues. 2021 Aug 12. doi: 10.1016/j.vhri.2021.06.003.

Key clinical point: Patients with psoriatic arthritis (PsA) performed poorly in all dimensions of the European Quality of Life (EQ-5D) scoring of quality of life (QoL) as compared with the general population, thus reflecting the detrimental effect of PsA on QoL.

Major finding: Overall, 87.3% and 69.8% of patients with PsA experienced pain/discomfort and anxiety/depression, respectively. Patients with PsA presented worse results in all dimensions of the EQ-5D scale and had a lower mean QoL score compared to the general population (0.651 vs. 0.793; P < .001) with worsened QoL in patients with concomitant use of nonsteroidal anti-inflammatory drugs (P = .035) and comorbidities (P = .003).

Study details: Findings are from a cross-sectional study including 212 adult patients with PsA from a single-center pharmacy in Minas Gerais, Brazil.

Disclosures: This study was supported by Minas Gerais Research Support Foundation and National Council for Scientific and Technological Development. Several of the authors declared receiving educational scholarships, grants, or personal fees from several sources.

Source: Moraes FA et al. Value Health Reg Issues. 2021 Aug 12. doi: 10.1016/j.vhri.2021.06.003.

Key clinical point: Patients with psoriatic arthritis (PsA) performed poorly in all dimensions of the European Quality of Life (EQ-5D) scoring of quality of life (QoL) as compared with the general population, thus reflecting the detrimental effect of PsA on QoL.

Major finding: Overall, 87.3% and 69.8% of patients with PsA experienced pain/discomfort and anxiety/depression, respectively. Patients with PsA presented worse results in all dimensions of the EQ-5D scale and had a lower mean QoL score compared to the general population (0.651 vs. 0.793; P < .001) with worsened QoL in patients with concomitant use of nonsteroidal anti-inflammatory drugs (P = .035) and comorbidities (P = .003).

Study details: Findings are from a cross-sectional study including 212 adult patients with PsA from a single-center pharmacy in Minas Gerais, Brazil.

Disclosures: This study was supported by Minas Gerais Research Support Foundation and National Council for Scientific and Technological Development. Several of the authors declared receiving educational scholarships, grants, or personal fees from several sources.

Source: Moraes FA et al. Value Health Reg Issues. 2021 Aug 12. doi: 10.1016/j.vhri.2021.06.003.

Key clinical point: Significant improvement in work productivity was observed in a real-world cohort of patients with psoriatic arthritis (PsA) treated with a tumor necrosis factor inhibitor (anti-TNF).

Major finding: At the final follow-up visit, the overall activity impairment decreased from 55.0 ± 21.5 to 16.3 ± 18.2 (P < .001). Moreover, absenteeism, mean presenteeism, and work productivity loss showed significant improvement upon treatment at the 9-month follow-up visit (all P < .001).

Study details: Findings are from a noninterventional, prospective, and observational cohort study including 120 patients with PsA who were receiving anti-TNF treatment.

Disclosures: This study was supported by AbbVie. Some of the authors declared receiving speaker’s fees, consulting fees, or research grants from various sources including AbbVie.

Source: Karadag O et al. Clin Rheumatol. 2021 Sep 3. doi: 10.1007/s10067-021-05893-3.

Key clinical point: Significant improvement in work productivity was observed in a real-world cohort of patients with psoriatic arthritis (PsA) treated with a tumor necrosis factor inhibitor (anti-TNF).

Major finding: At the final follow-up visit, the overall activity impairment decreased from 55.0 ± 21.5 to 16.3 ± 18.2 (P < .001). Moreover, absenteeism, mean presenteeism, and work productivity loss showed significant improvement upon treatment at the 9-month follow-up visit (all P < .001).

Study details: Findings are from a noninterventional, prospective, and observational cohort study including 120 patients with PsA who were receiving anti-TNF treatment.

Disclosures: This study was supported by AbbVie. Some of the authors declared receiving speaker’s fees, consulting fees, or research grants from various sources including AbbVie.

Source: Karadag O et al. Clin Rheumatol. 2021 Sep 3. doi: 10.1007/s10067-021-05893-3.

Key clinical point: Significant improvement in work productivity was observed in a real-world cohort of patients with psoriatic arthritis (PsA) treated with a tumor necrosis factor inhibitor (anti-TNF).

Major finding: At the final follow-up visit, the overall activity impairment decreased from 55.0 ± 21.5 to 16.3 ± 18.2 (P < .001). Moreover, absenteeism, mean presenteeism, and work productivity loss showed significant improvement upon treatment at the 9-month follow-up visit (all P < .001).

Study details: Findings are from a noninterventional, prospective, and observational cohort study including 120 patients with PsA who were receiving anti-TNF treatment.

Disclosures: This study was supported by AbbVie. Some of the authors declared receiving speaker’s fees, consulting fees, or research grants from various sources including AbbVie.

Source: Karadag O et al. Clin Rheumatol. 2021 Sep 3. doi: 10.1007/s10067-021-05893-3.