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How to best evaluate children’s melanocytic lesions for melanoma
Children often present for evaluation of a melanocytic lesion that is new, evolving, or worrisome to parents and caregivers.
“In the pediatric health care system, malignant melanoma is considered an especially heinous crime. In San Diego, dedicated pediatric providers who identify this disease are members of an elite squad known as the mole patrol unit.” Dr. Sheila Fallon Friedlander opened her presentation on pediatric moles with this tongue-in-cheek statement, adapted from the popular TV show “Law and Order SVU,” at a pediatric dermatology meeting sponsored by Rady Children’s Hospital–San Diego and University of California, San Diego.
Only 104 cases were diagnosed in children aged less than 10 years, and the melanoma incidence in this age group was relatively unchanging from 1973 to 2009. Dr. Friedlander further emphasized, “Pediatric melanoma is extremely uncommon in patients less than 10 years of age, but more likely to be atypical.”
She continued by describing a group of surgical oncologists at MD Anderson Cancer Center in Houston, who conducted a retrospective review of children with cutaneous melanoma between 1988 and 2007 included in the SEER database, to determine the influence of age on disease presentation. Preadolescents younger than age 10 years were more ethnically diverse (nonwhite), more frequently presented with nontruncal primary melanocytic lesions, and increasingly were diagnosed with advanced disease, compared with their adolescent counterparts (J Pediatr Surg. 2013 Nov;48[11]:2207-13).
Congenital melanocytic nevi (CMN) may have increased risk for malignant potential, and can be challenging for pediatric providers to manage. Among all CMN, the increase in melanoma risk is estimated as less than 1%. The risk for malignant melanoma is further increased in individuals with large or giant CMN (greater than 20 cm diameter adult size), with an absolute risk of approximately 2%-5%. The number of satellite nevi also is considered in risk stratification. The presence of greater than 20 satellite nevi is associated with a greater than fivefold risk of neurocutaneous melanosis. There is no documented association between an increased quantity of satellite nevi and malignant melanoma.
“One particularly challenging pigmented lesion identified among pediatric patients is a Spitz nevus,” according to Dr. Friedlander. This lesion presents with greater cytologic atypia than other benign congenital and acquired nevi, and often clinically mimics malignant melanoma if identified in adults. There also exists a subset of atypical Spitz nevi, consisting of lesions with greater cytologic atypia than benign Spitz nevi. A retrospective review at Massachusetts General Hospital, Boston, of 157 cases of Spitz-type melanocytic lesions identified between 1987 and 2002 revealed increased melanoma risk, minimal mortality, and moderate risk of regional lymph node metastasis (Arch Dermatol. 2011;147[10]:1173-9).
“Classic pediatric Spitz nevi with typical clinical features and history may be managed conservatively with clinical monitoring alone, but those with concerning features such as bleeding, asymmetry, or ulceration should be excised with clear margins,” Dr. Friedlander emphasized. She discouraged sentinel lymph node biopsy, however, given the positive outcomes of 24 patients at Boston Children’s Hospital with atypical Spitz nevi treated with excision alone, published by Cerrato et al. (Pediatr Dermatol. 2011 Dec 30;29[4]:448-53).
“In light of the rising incidence of pediatric melanoma, we need to identify high-risk patients, educate about mole surveillance, and encourage sun protection,” Dr. Friedlander stressed. Children with phenotype of Fitzpatrick I (fair skin, blonde or red hair, and blue eye color) are at highest risk, as are those with a high density of freckles who burn easily and tan poorly. Further risk factors highlighted include excessive sun exposure, indoor tanning, use of phototoxic medications, immunosuppression, and genetics. The first and best line of defense against harmful ultraviolet radiation is covering up (clothing with a tight weave, wet suits, and hats).
The American Academy of Pediatrics encourages staying in the shade when possible, and limiting sun exposure during the peak sun intensity hours, between 10 a.m. and 4 p.m. When physical protection is not possible, the American Academy of Dermatology endorses the application of water resistant, broad spectrum SPF of greater than 30 at least every 2 hours.
Children often present for evaluation of a melanocytic lesion that is new, evolving, or worrisome to parents and caregivers.
“In the pediatric health care system, malignant melanoma is considered an especially heinous crime. In San Diego, dedicated pediatric providers who identify this disease are members of an elite squad known as the mole patrol unit.” Dr. Sheila Fallon Friedlander opened her presentation on pediatric moles with this tongue-in-cheek statement, adapted from the popular TV show “Law and Order SVU,” at a pediatric dermatology meeting sponsored by Rady Children’s Hospital–San Diego and University of California, San Diego.
Only 104 cases were diagnosed in children aged less than 10 years, and the melanoma incidence in this age group was relatively unchanging from 1973 to 2009. Dr. Friedlander further emphasized, “Pediatric melanoma is extremely uncommon in patients less than 10 years of age, but more likely to be atypical.”
She continued by describing a group of surgical oncologists at MD Anderson Cancer Center in Houston, who conducted a retrospective review of children with cutaneous melanoma between 1988 and 2007 included in the SEER database, to determine the influence of age on disease presentation. Preadolescents younger than age 10 years were more ethnically diverse (nonwhite), more frequently presented with nontruncal primary melanocytic lesions, and increasingly were diagnosed with advanced disease, compared with their adolescent counterparts (J Pediatr Surg. 2013 Nov;48[11]:2207-13).
Congenital melanocytic nevi (CMN) may have increased risk for malignant potential, and can be challenging for pediatric providers to manage. Among all CMN, the increase in melanoma risk is estimated as less than 1%. The risk for malignant melanoma is further increased in individuals with large or giant CMN (greater than 20 cm diameter adult size), with an absolute risk of approximately 2%-5%. The number of satellite nevi also is considered in risk stratification. The presence of greater than 20 satellite nevi is associated with a greater than fivefold risk of neurocutaneous melanosis. There is no documented association between an increased quantity of satellite nevi and malignant melanoma.
“One particularly challenging pigmented lesion identified among pediatric patients is a Spitz nevus,” according to Dr. Friedlander. This lesion presents with greater cytologic atypia than other benign congenital and acquired nevi, and often clinically mimics malignant melanoma if identified in adults. There also exists a subset of atypical Spitz nevi, consisting of lesions with greater cytologic atypia than benign Spitz nevi. A retrospective review at Massachusetts General Hospital, Boston, of 157 cases of Spitz-type melanocytic lesions identified between 1987 and 2002 revealed increased melanoma risk, minimal mortality, and moderate risk of regional lymph node metastasis (Arch Dermatol. 2011;147[10]:1173-9).
“Classic pediatric Spitz nevi with typical clinical features and history may be managed conservatively with clinical monitoring alone, but those with concerning features such as bleeding, asymmetry, or ulceration should be excised with clear margins,” Dr. Friedlander emphasized. She discouraged sentinel lymph node biopsy, however, given the positive outcomes of 24 patients at Boston Children’s Hospital with atypical Spitz nevi treated with excision alone, published by Cerrato et al. (Pediatr Dermatol. 2011 Dec 30;29[4]:448-53).
“In light of the rising incidence of pediatric melanoma, we need to identify high-risk patients, educate about mole surveillance, and encourage sun protection,” Dr. Friedlander stressed. Children with phenotype of Fitzpatrick I (fair skin, blonde or red hair, and blue eye color) are at highest risk, as are those with a high density of freckles who burn easily and tan poorly. Further risk factors highlighted include excessive sun exposure, indoor tanning, use of phototoxic medications, immunosuppression, and genetics. The first and best line of defense against harmful ultraviolet radiation is covering up (clothing with a tight weave, wet suits, and hats).
The American Academy of Pediatrics encourages staying in the shade when possible, and limiting sun exposure during the peak sun intensity hours, between 10 a.m. and 4 p.m. When physical protection is not possible, the American Academy of Dermatology endorses the application of water resistant, broad spectrum SPF of greater than 30 at least every 2 hours.
Children often present for evaluation of a melanocytic lesion that is new, evolving, or worrisome to parents and caregivers.
“In the pediatric health care system, malignant melanoma is considered an especially heinous crime. In San Diego, dedicated pediatric providers who identify this disease are members of an elite squad known as the mole patrol unit.” Dr. Sheila Fallon Friedlander opened her presentation on pediatric moles with this tongue-in-cheek statement, adapted from the popular TV show “Law and Order SVU,” at a pediatric dermatology meeting sponsored by Rady Children’s Hospital–San Diego and University of California, San Diego.
Only 104 cases were diagnosed in children aged less than 10 years, and the melanoma incidence in this age group was relatively unchanging from 1973 to 2009. Dr. Friedlander further emphasized, “Pediatric melanoma is extremely uncommon in patients less than 10 years of age, but more likely to be atypical.”
She continued by describing a group of surgical oncologists at MD Anderson Cancer Center in Houston, who conducted a retrospective review of children with cutaneous melanoma between 1988 and 2007 included in the SEER database, to determine the influence of age on disease presentation. Preadolescents younger than age 10 years were more ethnically diverse (nonwhite), more frequently presented with nontruncal primary melanocytic lesions, and increasingly were diagnosed with advanced disease, compared with their adolescent counterparts (J Pediatr Surg. 2013 Nov;48[11]:2207-13).
Congenital melanocytic nevi (CMN) may have increased risk for malignant potential, and can be challenging for pediatric providers to manage. Among all CMN, the increase in melanoma risk is estimated as less than 1%. The risk for malignant melanoma is further increased in individuals with large or giant CMN (greater than 20 cm diameter adult size), with an absolute risk of approximately 2%-5%. The number of satellite nevi also is considered in risk stratification. The presence of greater than 20 satellite nevi is associated with a greater than fivefold risk of neurocutaneous melanosis. There is no documented association between an increased quantity of satellite nevi and malignant melanoma.
“One particularly challenging pigmented lesion identified among pediatric patients is a Spitz nevus,” according to Dr. Friedlander. This lesion presents with greater cytologic atypia than other benign congenital and acquired nevi, and often clinically mimics malignant melanoma if identified in adults. There also exists a subset of atypical Spitz nevi, consisting of lesions with greater cytologic atypia than benign Spitz nevi. A retrospective review at Massachusetts General Hospital, Boston, of 157 cases of Spitz-type melanocytic lesions identified between 1987 and 2002 revealed increased melanoma risk, minimal mortality, and moderate risk of regional lymph node metastasis (Arch Dermatol. 2011;147[10]:1173-9).
“Classic pediatric Spitz nevi with typical clinical features and history may be managed conservatively with clinical monitoring alone, but those with concerning features such as bleeding, asymmetry, or ulceration should be excised with clear margins,” Dr. Friedlander emphasized. She discouraged sentinel lymph node biopsy, however, given the positive outcomes of 24 patients at Boston Children’s Hospital with atypical Spitz nevi treated with excision alone, published by Cerrato et al. (Pediatr Dermatol. 2011 Dec 30;29[4]:448-53).
“In light of the rising incidence of pediatric melanoma, we need to identify high-risk patients, educate about mole surveillance, and encourage sun protection,” Dr. Friedlander stressed. Children with phenotype of Fitzpatrick I (fair skin, blonde or red hair, and blue eye color) are at highest risk, as are those with a high density of freckles who burn easily and tan poorly. Further risk factors highlighted include excessive sun exposure, indoor tanning, use of phototoxic medications, immunosuppression, and genetics. The first and best line of defense against harmful ultraviolet radiation is covering up (clothing with a tight weave, wet suits, and hats).
The American Academy of Pediatrics encourages staying in the shade when possible, and limiting sun exposure during the peak sun intensity hours, between 10 a.m. and 4 p.m. When physical protection is not possible, the American Academy of Dermatology endorses the application of water resistant, broad spectrum SPF of greater than 30 at least every 2 hours.
Contact dermatitis in children: The top 10 allergens
Contact dermatitis should be suspected in patients with eczematous dermatitis atypical in location, geometric or symmetric in distribution, or unresponsive to or worsened by common therapies, Dr. Catalina Matiz emphasized.
Allergic contact dermatitis is a complex disorder characterized by a type IV delayed-type hypersensitivity reaction that occurs when a patient’s skin is exposed to a substance easily penetrates the skin barrier.
Increasingly recognized in the United States, many pediatric patients are becoming sensitized to contact allergens found in personal care products, including skin care products, topical medications, and clothing.
A study published by Hill et al. in 2016 reviewed pediatric patch test studies to determine the top contact allergens in children (Expert Rev Clin Immunol. 2016;12[5]:551-61).
Dr. Matiz presented the top 10 allergens discovered by this group, and offered practical advice for allergen avoidance.
Topping the list in descending order are the following:
- Tixocortol pivalate (a corticosteroid).
- Propylene glycol.
- Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI).
- Formaldehyde.
- Cocamidopropyl betaine.
- Lanolin.
- Benzalkonium chloride.
- Fragrance and balsam of peru.
- Neomycin.
- Nickel.
Dr. Matiz educated meeting attendees on allergen-containing products and clinical correlations suggestive of allergic sensitization to common allergens. Tixocortol pivilate is a corticosteroid present in Class A corticosteroids including hydrocortisone acetate. She highlighted the cross reactivity between class A and class D2 corticosteroids including hydrocortisone butyrate and valerate.
“Usually topical corticosteroid–contact sensitivity manifests as a failure to improve or worsening of existing dermatitis,” emphasized Dr. Matiz of departments of dermatology and pediatrics at the university.
Propylene glycol, benzalkonium chloride, and neomycin also represent top contact allergens frequently found in topical medications. Similarly, lanolin contact sensitivity often presents as refractory or worsening atopic dermatitis. “Lanolin, also known as wool alcohol, is commonly found in emollients, medications, and personal care products used by atopic dermatitis patients,” Dr. Matiz stressed.
Methylchloroisothiazolinone/methylisothiazolinone represent preservatives commonly found in wet wipes, hypoallergenic, and sensitive skin products. This was the allergen of the year in 2013 and was subsequently removed from many wet wipe formulations and products in response.
In addition to acute management of allergic contact dermatitis with corticosteroids, Dr. Matiz further emphasized the importance of preemptive avoidance of the top ten allergens.
She recommends patch testing if no clinical improvement is evident after 8 weeks of common allergen avoidance, for definitive allergen identification.
Dr. Matiz said she had no relevant financial disclosures.
Contact dermatitis should be suspected in patients with eczematous dermatitis atypical in location, geometric or symmetric in distribution, or unresponsive to or worsened by common therapies, Dr. Catalina Matiz emphasized.
Allergic contact dermatitis is a complex disorder characterized by a type IV delayed-type hypersensitivity reaction that occurs when a patient’s skin is exposed to a substance easily penetrates the skin barrier.
Increasingly recognized in the United States, many pediatric patients are becoming sensitized to contact allergens found in personal care products, including skin care products, topical medications, and clothing.
A study published by Hill et al. in 2016 reviewed pediatric patch test studies to determine the top contact allergens in children (Expert Rev Clin Immunol. 2016;12[5]:551-61).
Dr. Matiz presented the top 10 allergens discovered by this group, and offered practical advice for allergen avoidance.
Topping the list in descending order are the following:
- Tixocortol pivalate (a corticosteroid).
- Propylene glycol.
- Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI).
- Formaldehyde.
- Cocamidopropyl betaine.
- Lanolin.
- Benzalkonium chloride.
- Fragrance and balsam of peru.
- Neomycin.
- Nickel.
Dr. Matiz educated meeting attendees on allergen-containing products and clinical correlations suggestive of allergic sensitization to common allergens. Tixocortol pivilate is a corticosteroid present in Class A corticosteroids including hydrocortisone acetate. She highlighted the cross reactivity between class A and class D2 corticosteroids including hydrocortisone butyrate and valerate.
“Usually topical corticosteroid–contact sensitivity manifests as a failure to improve or worsening of existing dermatitis,” emphasized Dr. Matiz of departments of dermatology and pediatrics at the university.
Propylene glycol, benzalkonium chloride, and neomycin also represent top contact allergens frequently found in topical medications. Similarly, lanolin contact sensitivity often presents as refractory or worsening atopic dermatitis. “Lanolin, also known as wool alcohol, is commonly found in emollients, medications, and personal care products used by atopic dermatitis patients,” Dr. Matiz stressed.
Methylchloroisothiazolinone/methylisothiazolinone represent preservatives commonly found in wet wipes, hypoallergenic, and sensitive skin products. This was the allergen of the year in 2013 and was subsequently removed from many wet wipe formulations and products in response.
In addition to acute management of allergic contact dermatitis with corticosteroids, Dr. Matiz further emphasized the importance of preemptive avoidance of the top ten allergens.
She recommends patch testing if no clinical improvement is evident after 8 weeks of common allergen avoidance, for definitive allergen identification.
Dr. Matiz said she had no relevant financial disclosures.
Contact dermatitis should be suspected in patients with eczematous dermatitis atypical in location, geometric or symmetric in distribution, or unresponsive to or worsened by common therapies, Dr. Catalina Matiz emphasized.
Allergic contact dermatitis is a complex disorder characterized by a type IV delayed-type hypersensitivity reaction that occurs when a patient’s skin is exposed to a substance easily penetrates the skin barrier.
Increasingly recognized in the United States, many pediatric patients are becoming sensitized to contact allergens found in personal care products, including skin care products, topical medications, and clothing.
A study published by Hill et al. in 2016 reviewed pediatric patch test studies to determine the top contact allergens in children (Expert Rev Clin Immunol. 2016;12[5]:551-61).
Dr. Matiz presented the top 10 allergens discovered by this group, and offered practical advice for allergen avoidance.
Topping the list in descending order are the following:
- Tixocortol pivalate (a corticosteroid).
- Propylene glycol.
- Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI).
- Formaldehyde.
- Cocamidopropyl betaine.
- Lanolin.
- Benzalkonium chloride.
- Fragrance and balsam of peru.
- Neomycin.
- Nickel.
Dr. Matiz educated meeting attendees on allergen-containing products and clinical correlations suggestive of allergic sensitization to common allergens. Tixocortol pivilate is a corticosteroid present in Class A corticosteroids including hydrocortisone acetate. She highlighted the cross reactivity between class A and class D2 corticosteroids including hydrocortisone butyrate and valerate.
“Usually topical corticosteroid–contact sensitivity manifests as a failure to improve or worsening of existing dermatitis,” emphasized Dr. Matiz of departments of dermatology and pediatrics at the university.
Propylene glycol, benzalkonium chloride, and neomycin also represent top contact allergens frequently found in topical medications. Similarly, lanolin contact sensitivity often presents as refractory or worsening atopic dermatitis. “Lanolin, also known as wool alcohol, is commonly found in emollients, medications, and personal care products used by atopic dermatitis patients,” Dr. Matiz stressed.
Methylchloroisothiazolinone/methylisothiazolinone represent preservatives commonly found in wet wipes, hypoallergenic, and sensitive skin products. This was the allergen of the year in 2013 and was subsequently removed from many wet wipe formulations and products in response.
In addition to acute management of allergic contact dermatitis with corticosteroids, Dr. Matiz further emphasized the importance of preemptive avoidance of the top ten allergens.
She recommends patch testing if no clinical improvement is evident after 8 weeks of common allergen avoidance, for definitive allergen identification.
Dr. Matiz said she had no relevant financial disclosures.