Is exercise therapy effective treatment for low back pain?

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Is exercise therapy effective treatment for low back pain?

EVIDENCE SUMMARY

General exercise offers benefit …at least for chronic LBP

A 2017 systematic review of 4 systematic reviews and 50 RCTs (122 total trials) evaluated general exercise vs usual care for acute (< 4 weeks), subacute (4 to 12 weeks), or chronic (≥ 12 weeks) LBP with or without radiculopathy in adults.1 Exercise was not consistently associated with decreased pain in acute or subacute LBP. For chronic LBP, 3 RCTs (n = 200) associated exercise with decreased pain (weighted mean difference [WMD] = –9.2 on a 0-100 point visual acuity scale; 95% CI, –16.0 to –2.4) and improved function (WMD = –12.4 on the Oswestry Disability Index; 95% CI, –23.0 to –1.7) at short-term follow-up (≤ 3 months). This effect was found to decrease at long-term (≥ 1 year) follow-up (WMD for pain = –4.9; 95% CI, –10.5 to 0.6 and WMD for function = –3.2; 95% CI, 6.0 to –0.4). In a meta-analysis of 10 studies (n = 1992) included in this systematic review, exercise was associated with a lower likelihood of work disability (odds ratio, 0.66; CI, 0.48 to 0.92) at 12 months.1

Yoga, Pilates, and motor control exercise: Your results may vary

Several reviews have explored the effects of specific exercise modalities on LBP. A 2017 meta-analysis of 9 RCTs in the United States, United Kingdom, and India of nonpregnant adults (≥ 18 years old) with chronic LBP (N = 810) found that yoga (any tradition of yoga with a physical component) vs no exercise demonstrated a statistically, but not clinically, significant decrease in pain at 3 to 4 months (mean difference [MD] = –4.6 on a 0-100 point scale; 95% CI, –7.0 to –2.1), 6 months (MD = –7.8; 95% CI, –13.4 to –2.3), and 12 months (MD = –5.4; 95% CI, –14.5 to –3.7). Clinically significant pain benefit was considered a change of 15 or more points.2

A 2015 meta-analysis of RCTs (10 trials; N = 510) comparing the effects of Pilates (a form of body conditioning involving isometric contractions and core exercises focusing on stability) vs minimal intervention on chronic (> 12 weeks) LBP in nonpregnant adults (≥ 16 years old) found low-quality evidence for decreased pain at short-term follow-up (≤ 3 months; MD = –14.1 on a 0-100 point scale; 95% CI, –18.9 to –9.2). There was moderate-quality evidence for decreased pain at intermediate follow-up (3-12 months; MD = –10.5; 95% CI, –18.5 to –2.6).3

A 2016 systematic review evaluated motor control exercise (MCE; a form of exercise that focuses on trunk muscle control and coordination) in adults (≥ 16 years old) with chronic LBP (≥ 12 weeks). There was low- to moderate-quality evidence that, compared to minimal intervention, MCE decreases pain at short-term (≤ 6 months; 4 RCTs; MD = –10.0 on a 0-100 point scale; 95% CI, –15.7 to –4.4), intermediate (6-12 months; 4 RCTs; MD = –12.6; 95% CI, –20.5 to –4.7), and long-term follow-up (> 12 months; 3 RCTs; MD = –13.0; 95% CI, –18.5 to –7.4). When comparing MCE to general exercise, there were no clinically significant differences in pain or disability at intermediate and long-term follow-up.4Common limitations included heterogeneity of intervention methodology, inability to blind results, inability to assess cointerventions, and in some cases, small sample sizes of trials.

Recommendations from others

The 2017 American College of Physicians (ACP) clinical practice guideline on noninvasive treatments for LBP does not recommend exercise therapy in acute or subacute LBP; recommended therapies include superficial heat, massage, acupuncture, or spinal manipulation.5 The ACP recommends general exercise, yoga, tai chi, or MCE for chronic LBP, in addition to multidisciplinary rehabilitation, acupuncture, mindfulness-based stress reduction, progressive relaxation, biofeedback, laser therapy, operant therapy, cognitive behavioral therapy, or spinal manipulation.

The 2017 US Department of Veterans Affairs and US Department of Defense clinical practice guideline on treatment of LBP notes insufficient evidence for benefit of clinician-guided exercise therapy in acute LBP.6 For chronic LBP, clinician-directed exercise, yoga, tai chi, or Pilates is recommended.

Editor’s takeaway

Convincing evidence demonstrates that exercise modestly improves chronic LBP—but only modestly (4% to 15%), and not in acute LBP. This small magnitude of effect may disappoint expectations, but exercise remains among our better interventions for this common chronic problem. Few—if any—interventions have proven better, and exercise has beneficial side effects, a low cost, and widespread availability.

References

1. Chou R, Deyo R, Friedly J, et al. Nonpharmacologic therapies for low back pain: a systematic review for an American College of Physicians clinical practice guideline. Ann Intern Med. 2017;166:493-506. doi: 10.7326/M16-2459

2. Wieland LS, Skoetz N, Pilkington K, et al. Yoga treatment for chronic non-specific low back pain (review). Cochrane Database Syst Rev. 2017;1:CD010671. doi: 10.1002/14651858.CD010671.pub2

3. Yamato TP, Maher CG, Saragiotto BT, et al. Pilates for low back pain. Cochrane Database Syst Rev. 2015;7:CD010265. doi: 10.1002/14651858.CD010265.pub2

4. Saragiotto BT, Maher CG, Yamato TP, et. al. Motor control exercise for chronic non‐specific low‐back pain. Cochrane Database Syst Rev. 2016;1:CD012004. doi: 10.1002/14651858.CD012004

5. Qaseem A, Wilt TJ, McLean RM, et al; Clinical Guidelines Committee of the American College of Physicians. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;166:514-530. doi: 10.7326/M16-2367

6. Pangarkar SS, Kang DG, Sandbrink F, et al. VA/DoD clinical practice guideline: diagnosis and treatment of low back pain. J Gen Intern Med. 2019;34:2620-2629. doi: 10.1007/s11606-019-05086-4

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Christine Broszko, MD, FAAFP
Krystyna Golden, MD
Cody R. Holmes, MD
Stephanie Fulleborn, MD

Eglin Air Force Base Family Medicine Residency, FL

Carolyn Biglow, MLIS, CAS
Carnegie Library of Pittsburgh, PA

DEPUTY EDITOR
Richard Guthmann, MD, MPH

Advocate Illinois Masonic Family Medicine Residency

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the US Air Force Medical Department, the Air Force at large, or the Department of Defense.

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Christine Broszko, MD, FAAFP
Krystyna Golden, MD
Cody R. Holmes, MD
Stephanie Fulleborn, MD

Eglin Air Force Base Family Medicine Residency, FL

Carolyn Biglow, MLIS, CAS
Carnegie Library of Pittsburgh, PA

DEPUTY EDITOR
Richard Guthmann, MD, MPH

Advocate Illinois Masonic Family Medicine Residency

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the US Air Force Medical Department, the Air Force at large, or the Department of Defense.

Author and Disclosure Information

Christine Broszko, MD, FAAFP
Krystyna Golden, MD
Cody R. Holmes, MD
Stephanie Fulleborn, MD

Eglin Air Force Base Family Medicine Residency, FL

Carolyn Biglow, MLIS, CAS
Carnegie Library of Pittsburgh, PA

DEPUTY EDITOR
Richard Guthmann, MD, MPH

Advocate Illinois Masonic Family Medicine Residency

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the US Air Force Medical Department, the Air Force at large, or the Department of Defense.

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EVIDENCE SUMMARY

General exercise offers benefit …at least for chronic LBP

A 2017 systematic review of 4 systematic reviews and 50 RCTs (122 total trials) evaluated general exercise vs usual care for acute (< 4 weeks), subacute (4 to 12 weeks), or chronic (≥ 12 weeks) LBP with or without radiculopathy in adults.1 Exercise was not consistently associated with decreased pain in acute or subacute LBP. For chronic LBP, 3 RCTs (n = 200) associated exercise with decreased pain (weighted mean difference [WMD] = –9.2 on a 0-100 point visual acuity scale; 95% CI, –16.0 to –2.4) and improved function (WMD = –12.4 on the Oswestry Disability Index; 95% CI, –23.0 to –1.7) at short-term follow-up (≤ 3 months). This effect was found to decrease at long-term (≥ 1 year) follow-up (WMD for pain = –4.9; 95% CI, –10.5 to 0.6 and WMD for function = –3.2; 95% CI, 6.0 to –0.4). In a meta-analysis of 10 studies (n = 1992) included in this systematic review, exercise was associated with a lower likelihood of work disability (odds ratio, 0.66; CI, 0.48 to 0.92) at 12 months.1

Yoga, Pilates, and motor control exercise: Your results may vary

Several reviews have explored the effects of specific exercise modalities on LBP. A 2017 meta-analysis of 9 RCTs in the United States, United Kingdom, and India of nonpregnant adults (≥ 18 years old) with chronic LBP (N = 810) found that yoga (any tradition of yoga with a physical component) vs no exercise demonstrated a statistically, but not clinically, significant decrease in pain at 3 to 4 months (mean difference [MD] = –4.6 on a 0-100 point scale; 95% CI, –7.0 to –2.1), 6 months (MD = –7.8; 95% CI, –13.4 to –2.3), and 12 months (MD = –5.4; 95% CI, –14.5 to –3.7). Clinically significant pain benefit was considered a change of 15 or more points.2

A 2015 meta-analysis of RCTs (10 trials; N = 510) comparing the effects of Pilates (a form of body conditioning involving isometric contractions and core exercises focusing on stability) vs minimal intervention on chronic (> 12 weeks) LBP in nonpregnant adults (≥ 16 years old) found low-quality evidence for decreased pain at short-term follow-up (≤ 3 months; MD = –14.1 on a 0-100 point scale; 95% CI, –18.9 to –9.2). There was moderate-quality evidence for decreased pain at intermediate follow-up (3-12 months; MD = –10.5; 95% CI, –18.5 to –2.6).3

A 2016 systematic review evaluated motor control exercise (MCE; a form of exercise that focuses on trunk muscle control and coordination) in adults (≥ 16 years old) with chronic LBP (≥ 12 weeks). There was low- to moderate-quality evidence that, compared to minimal intervention, MCE decreases pain at short-term (≤ 6 months; 4 RCTs; MD = –10.0 on a 0-100 point scale; 95% CI, –15.7 to –4.4), intermediate (6-12 months; 4 RCTs; MD = –12.6; 95% CI, –20.5 to –4.7), and long-term follow-up (> 12 months; 3 RCTs; MD = –13.0; 95% CI, –18.5 to –7.4). When comparing MCE to general exercise, there were no clinically significant differences in pain or disability at intermediate and long-term follow-up.4Common limitations included heterogeneity of intervention methodology, inability to blind results, inability to assess cointerventions, and in some cases, small sample sizes of trials.

Recommendations from others

The 2017 American College of Physicians (ACP) clinical practice guideline on noninvasive treatments for LBP does not recommend exercise therapy in acute or subacute LBP; recommended therapies include superficial heat, massage, acupuncture, or spinal manipulation.5 The ACP recommends general exercise, yoga, tai chi, or MCE for chronic LBP, in addition to multidisciplinary rehabilitation, acupuncture, mindfulness-based stress reduction, progressive relaxation, biofeedback, laser therapy, operant therapy, cognitive behavioral therapy, or spinal manipulation.

The 2017 US Department of Veterans Affairs and US Department of Defense clinical practice guideline on treatment of LBP notes insufficient evidence for benefit of clinician-guided exercise therapy in acute LBP.6 For chronic LBP, clinician-directed exercise, yoga, tai chi, or Pilates is recommended.

Editor’s takeaway

Convincing evidence demonstrates that exercise modestly improves chronic LBP—but only modestly (4% to 15%), and not in acute LBP. This small magnitude of effect may disappoint expectations, but exercise remains among our better interventions for this common chronic problem. Few—if any—interventions have proven better, and exercise has beneficial side effects, a low cost, and widespread availability.

EVIDENCE SUMMARY

General exercise offers benefit …at least for chronic LBP

A 2017 systematic review of 4 systematic reviews and 50 RCTs (122 total trials) evaluated general exercise vs usual care for acute (< 4 weeks), subacute (4 to 12 weeks), or chronic (≥ 12 weeks) LBP with or without radiculopathy in adults.1 Exercise was not consistently associated with decreased pain in acute or subacute LBP. For chronic LBP, 3 RCTs (n = 200) associated exercise with decreased pain (weighted mean difference [WMD] = –9.2 on a 0-100 point visual acuity scale; 95% CI, –16.0 to –2.4) and improved function (WMD = –12.4 on the Oswestry Disability Index; 95% CI, –23.0 to –1.7) at short-term follow-up (≤ 3 months). This effect was found to decrease at long-term (≥ 1 year) follow-up (WMD for pain = –4.9; 95% CI, –10.5 to 0.6 and WMD for function = –3.2; 95% CI, 6.0 to –0.4). In a meta-analysis of 10 studies (n = 1992) included in this systematic review, exercise was associated with a lower likelihood of work disability (odds ratio, 0.66; CI, 0.48 to 0.92) at 12 months.1

Yoga, Pilates, and motor control exercise: Your results may vary

Several reviews have explored the effects of specific exercise modalities on LBP. A 2017 meta-analysis of 9 RCTs in the United States, United Kingdom, and India of nonpregnant adults (≥ 18 years old) with chronic LBP (N = 810) found that yoga (any tradition of yoga with a physical component) vs no exercise demonstrated a statistically, but not clinically, significant decrease in pain at 3 to 4 months (mean difference [MD] = –4.6 on a 0-100 point scale; 95% CI, –7.0 to –2.1), 6 months (MD = –7.8; 95% CI, –13.4 to –2.3), and 12 months (MD = –5.4; 95% CI, –14.5 to –3.7). Clinically significant pain benefit was considered a change of 15 or more points.2

A 2015 meta-analysis of RCTs (10 trials; N = 510) comparing the effects of Pilates (a form of body conditioning involving isometric contractions and core exercises focusing on stability) vs minimal intervention on chronic (> 12 weeks) LBP in nonpregnant adults (≥ 16 years old) found low-quality evidence for decreased pain at short-term follow-up (≤ 3 months; MD = –14.1 on a 0-100 point scale; 95% CI, –18.9 to –9.2). There was moderate-quality evidence for decreased pain at intermediate follow-up (3-12 months; MD = –10.5; 95% CI, –18.5 to –2.6).3

A 2016 systematic review evaluated motor control exercise (MCE; a form of exercise that focuses on trunk muscle control and coordination) in adults (≥ 16 years old) with chronic LBP (≥ 12 weeks). There was low- to moderate-quality evidence that, compared to minimal intervention, MCE decreases pain at short-term (≤ 6 months; 4 RCTs; MD = –10.0 on a 0-100 point scale; 95% CI, –15.7 to –4.4), intermediate (6-12 months; 4 RCTs; MD = –12.6; 95% CI, –20.5 to –4.7), and long-term follow-up (> 12 months; 3 RCTs; MD = –13.0; 95% CI, –18.5 to –7.4). When comparing MCE to general exercise, there were no clinically significant differences in pain or disability at intermediate and long-term follow-up.4Common limitations included heterogeneity of intervention methodology, inability to blind results, inability to assess cointerventions, and in some cases, small sample sizes of trials.

Recommendations from others

The 2017 American College of Physicians (ACP) clinical practice guideline on noninvasive treatments for LBP does not recommend exercise therapy in acute or subacute LBP; recommended therapies include superficial heat, massage, acupuncture, or spinal manipulation.5 The ACP recommends general exercise, yoga, tai chi, or MCE for chronic LBP, in addition to multidisciplinary rehabilitation, acupuncture, mindfulness-based stress reduction, progressive relaxation, biofeedback, laser therapy, operant therapy, cognitive behavioral therapy, or spinal manipulation.

The 2017 US Department of Veterans Affairs and US Department of Defense clinical practice guideline on treatment of LBP notes insufficient evidence for benefit of clinician-guided exercise therapy in acute LBP.6 For chronic LBP, clinician-directed exercise, yoga, tai chi, or Pilates is recommended.

Editor’s takeaway

Convincing evidence demonstrates that exercise modestly improves chronic LBP—but only modestly (4% to 15%), and not in acute LBP. This small magnitude of effect may disappoint expectations, but exercise remains among our better interventions for this common chronic problem. Few—if any—interventions have proven better, and exercise has beneficial side effects, a low cost, and widespread availability.

References

1. Chou R, Deyo R, Friedly J, et al. Nonpharmacologic therapies for low back pain: a systematic review for an American College of Physicians clinical practice guideline. Ann Intern Med. 2017;166:493-506. doi: 10.7326/M16-2459

2. Wieland LS, Skoetz N, Pilkington K, et al. Yoga treatment for chronic non-specific low back pain (review). Cochrane Database Syst Rev. 2017;1:CD010671. doi: 10.1002/14651858.CD010671.pub2

3. Yamato TP, Maher CG, Saragiotto BT, et al. Pilates for low back pain. Cochrane Database Syst Rev. 2015;7:CD010265. doi: 10.1002/14651858.CD010265.pub2

4. Saragiotto BT, Maher CG, Yamato TP, et. al. Motor control exercise for chronic non‐specific low‐back pain. Cochrane Database Syst Rev. 2016;1:CD012004. doi: 10.1002/14651858.CD012004

5. Qaseem A, Wilt TJ, McLean RM, et al; Clinical Guidelines Committee of the American College of Physicians. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;166:514-530. doi: 10.7326/M16-2367

6. Pangarkar SS, Kang DG, Sandbrink F, et al. VA/DoD clinical practice guideline: diagnosis and treatment of low back pain. J Gen Intern Med. 2019;34:2620-2629. doi: 10.1007/s11606-019-05086-4

References

1. Chou R, Deyo R, Friedly J, et al. Nonpharmacologic therapies for low back pain: a systematic review for an American College of Physicians clinical practice guideline. Ann Intern Med. 2017;166:493-506. doi: 10.7326/M16-2459

2. Wieland LS, Skoetz N, Pilkington K, et al. Yoga treatment for chronic non-specific low back pain (review). Cochrane Database Syst Rev. 2017;1:CD010671. doi: 10.1002/14651858.CD010671.pub2

3. Yamato TP, Maher CG, Saragiotto BT, et al. Pilates for low back pain. Cochrane Database Syst Rev. 2015;7:CD010265. doi: 10.1002/14651858.CD010265.pub2

4. Saragiotto BT, Maher CG, Yamato TP, et. al. Motor control exercise for chronic non‐specific low‐back pain. Cochrane Database Syst Rev. 2016;1:CD012004. doi: 10.1002/14651858.CD012004

5. Qaseem A, Wilt TJ, McLean RM, et al; Clinical Guidelines Committee of the American College of Physicians. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;166:514-530. doi: 10.7326/M16-2367

6. Pangarkar SS, Kang DG, Sandbrink F, et al. VA/DoD clinical practice guideline: diagnosis and treatment of low back pain. J Gen Intern Med. 2019;34:2620-2629. doi: 10.1007/s11606-019-05086-4

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EVIDENCE-BASED ANSWER:

Yes, it is somewhat effective. Exercise therapy—including general exercise, yoga, Pilates, and motor control exercise—has been shown to modestly decrease pain in chronic low back pain (LBP); levels of benefit in short- (≤ 3 months) and long- (≥ 1 year) term follow-up range from 4% to 15% improvement (strength of recommendation [SOR] A, based on a systematic review of randomized controlled trials [RCTs]).

Exercise therapy may improve function and decrease work disability in subacute and chronic LBP, respectively (SOR A, based on a meta-analysis of RCTs). Exercise therapy has not been associated with improvement in acute LBP (SOR A, based on a meta-analysis of RCTs).

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