When patients seek primary care, it’s becoming more likely that they’ll see a nurse practitioner or physician assistant.

Health care visits to NPs and PAs, also known as advanced practice providers, have been rising in recent years compared with doctor visits, according to the latest studies. The proportion of Medicare visits that NPs and PAs delivered nearly doubled in the 7-year period 2013-2019 (14% in 2013 to 26% in 2019), according to research published this month in the BMJ. Among study participants, 42% had at least one visit with an NP or PA. Meanwhile, primary care visits with a physician decreased by 18%, the study showed.

Medicare accounts for roughly 20% of the U.S. population and 23% of health care spending, according to 2023 data cited in the report. Study authors surveyed a random sample, 20% of Medicare recipients who sought care through in-person and telemedicine visits to outpatient and nursing facilities before the COVID-19 pandemic.

Medical clinics have turned to NPs and PAs to offset a shortage of primary care doctors, with the United States having fewer physicians per capita than other industrialized nations, according to Ateev Mehrotra, MD, MPH, professor of health care policy at Harvard Medical School and one of the authors of the BMJ report.

Nursing schools also struggle to meet the growing demand for NPs. In more than half of U.S. states, NPs can work independently without physician supervision, while PAs face more restrictions.

Another study earlier this year also found a rise in APP care. FAIR Health reported that nearly one in three patients received care between 2016 and 2022 from someone other than a physician, with NPs providing 27% of primary care visits and PAs, 15%.

The trend isn’t new. But for many years, claims data from Medicare or commercial payers masked the impact of advanced practitioners because their care was billed under a supervising physician, explained Michael L. Powe, vice president of reimbursement and professional advocacy for the American Academy of Physician Assistants, which represents PAs.

NPs and PAs are more likely to see patients with lower incomes, those who live in rural communities, or those who have disabilities, according to the BMJ study, suggesting that these providers may improve access to health care.

They already comprise about half of the primary care professionals in rural areas, said Stephen Ferrara, DNP, president of the American Association of Nurse Practitioners, citing a 2022 report by the Medicare Payment Advisory Commission.

The BMJ study also found that NPs and PAs were more likely to see patients for certain conditions. For example, they handled 42% of visits for respiratory infections and 37% of visits for anxiety, compared with only 13% of visits for eye problems and 20% of visits for hypertension.

Dr. Mehrotra said patients, in general, are still unlikely to see only an NP for many conditions, particularly chronic illness. “You might see the physician one time and then the nurse practitioner, and then the PA. And you might see another physician in the practice.”

He said health care leaders need to decide how to set up teams to best serve patients. From a health policy perspective, they should also consider whether to boost funding for NP and PA education or primary care residencies.

Meanwhile, the growth of advanced practitioners continues. The Bureau of Labor Statistics estimates that the number of NPs will increase to 359,000 in 2031 (80% growth from 2019) and the number of PAs will increase to 178,000 (48% growth).
 

A version of this article first appeared on Medscape.com.

When patients seek primary care, it’s becoming more likely that they’ll see a nurse practitioner or physician assistant.

Health care visits to NPs and PAs, also known as advanced practice providers, have been rising in recent years compared with doctor visits, according to the latest studies. The proportion of Medicare visits that NPs and PAs delivered nearly doubled in the 7-year period 2013-2019 (14% in 2013 to 26% in 2019), according to research published this month in the BMJ. Among study participants, 42% had at least one visit with an NP or PA. Meanwhile, primary care visits with a physician decreased by 18%, the study showed.

Medicare accounts for roughly 20% of the U.S. population and 23% of health care spending, according to 2023 data cited in the report. Study authors surveyed a random sample, 20% of Medicare recipients who sought care through in-person and telemedicine visits to outpatient and nursing facilities before the COVID-19 pandemic.

Medical clinics have turned to NPs and PAs to offset a shortage of primary care doctors, with the United States having fewer physicians per capita than other industrialized nations, according to Ateev Mehrotra, MD, MPH, professor of health care policy at Harvard Medical School and one of the authors of the BMJ report.

Nursing schools also struggle to meet the growing demand for NPs. In more than half of U.S. states, NPs can work independently without physician supervision, while PAs face more restrictions.

Another study earlier this year also found a rise in APP care. FAIR Health reported that nearly one in three patients received care between 2016 and 2022 from someone other than a physician, with NPs providing 27% of primary care visits and PAs, 15%.

The trend isn’t new. But for many years, claims data from Medicare or commercial payers masked the impact of advanced practitioners because their care was billed under a supervising physician, explained Michael L. Powe, vice president of reimbursement and professional advocacy for the American Academy of Physician Assistants, which represents PAs.

NPs and PAs are more likely to see patients with lower incomes, those who live in rural communities, or those who have disabilities, according to the BMJ study, suggesting that these providers may improve access to health care.

They already comprise about half of the primary care professionals in rural areas, said Stephen Ferrara, DNP, president of the American Association of Nurse Practitioners, citing a 2022 report by the Medicare Payment Advisory Commission.

The BMJ study also found that NPs and PAs were more likely to see patients for certain conditions. For example, they handled 42% of visits for respiratory infections and 37% of visits for anxiety, compared with only 13% of visits for eye problems and 20% of visits for hypertension.

Dr. Mehrotra said patients, in general, are still unlikely to see only an NP for many conditions, particularly chronic illness. “You might see the physician one time and then the nurse practitioner, and then the PA. And you might see another physician in the practice.”

He said health care leaders need to decide how to set up teams to best serve patients. From a health policy perspective, they should also consider whether to boost funding for NP and PA education or primary care residencies.

Meanwhile, the growth of advanced practitioners continues. The Bureau of Labor Statistics estimates that the number of NPs will increase to 359,000 in 2031 (80% growth from 2019) and the number of PAs will increase to 178,000 (48% growth).
 

A version of this article first appeared on Medscape.com.

When patients seek primary care, it’s becoming more likely that they’ll see a nurse practitioner or physician assistant.

Health care visits to NPs and PAs, also known as advanced practice providers, have been rising in recent years compared with doctor visits, according to the latest studies. The proportion of Medicare visits that NPs and PAs delivered nearly doubled in the 7-year period 2013-2019 (14% in 2013 to 26% in 2019), according to research published this month in the BMJ. Among study participants, 42% had at least one visit with an NP or PA. Meanwhile, primary care visits with a physician decreased by 18%, the study showed.

Medicare accounts for roughly 20% of the U.S. population and 23% of health care spending, according to 2023 data cited in the report. Study authors surveyed a random sample, 20% of Medicare recipients who sought care through in-person and telemedicine visits to outpatient and nursing facilities before the COVID-19 pandemic.

Medical clinics have turned to NPs and PAs to offset a shortage of primary care doctors, with the United States having fewer physicians per capita than other industrialized nations, according to Ateev Mehrotra, MD, MPH, professor of health care policy at Harvard Medical School and one of the authors of the BMJ report.

Nursing schools also struggle to meet the growing demand for NPs. In more than half of U.S. states, NPs can work independently without physician supervision, while PAs face more restrictions.

Another study earlier this year also found a rise in APP care. FAIR Health reported that nearly one in three patients received care between 2016 and 2022 from someone other than a physician, with NPs providing 27% of primary care visits and PAs, 15%.

The trend isn’t new. But for many years, claims data from Medicare or commercial payers masked the impact of advanced practitioners because their care was billed under a supervising physician, explained Michael L. Powe, vice president of reimbursement and professional advocacy for the American Academy of Physician Assistants, which represents PAs.

NPs and PAs are more likely to see patients with lower incomes, those who live in rural communities, or those who have disabilities, according to the BMJ study, suggesting that these providers may improve access to health care.

They already comprise about half of the primary care professionals in rural areas, said Stephen Ferrara, DNP, president of the American Association of Nurse Practitioners, citing a 2022 report by the Medicare Payment Advisory Commission.

The BMJ study also found that NPs and PAs were more likely to see patients for certain conditions. For example, they handled 42% of visits for respiratory infections and 37% of visits for anxiety, compared with only 13% of visits for eye problems and 20% of visits for hypertension.

Dr. Mehrotra said patients, in general, are still unlikely to see only an NP for many conditions, particularly chronic illness. “You might see the physician one time and then the nurse practitioner, and then the PA. And you might see another physician in the practice.”

He said health care leaders need to decide how to set up teams to best serve patients. From a health policy perspective, they should also consider whether to boost funding for NP and PA education or primary care residencies.

Meanwhile, the growth of advanced practitioners continues. The Bureau of Labor Statistics estimates that the number of NPs will increase to 359,000 in 2031 (80% growth from 2019) and the number of PAs will increase to 178,000 (48% growth).
 

A version of this article first appeared on Medscape.com.

TOPLINE:

Blood samples from healthy adults show an inhibition of neutrophil extracellular trap formation (NET) after 1 week of daily ginger supplements.

METHODOLOGY:

• Researchers recruited nine healthy adults aged 18-38 years to receive a 100-mg oral ginger supplement daily for 7 consecutive days.
• Blood samples were collected at baseline and on days 7 and 14, with isolation of neutrophils, peripheral blood mononuclear cells, and plasma.
• The researchers measured NET formation (NETosis) as a way to show the effect of ginger on inflammation.

TAKEAWAY:

• Measures of neutrophil cyclic AMP (cAMP) were significantly higher after 7 days of ginger supplements, compared with baseline levels, although these levels returned to near baseline by 1 week after discontinuing ginger consumption.
• Oral ginger supplements reduced neutrophil phosphodiesterase (PDE) activity by 40% from baseline, similar to results seen with synthetic PDE4 inhibitors.
• The results build on previous studies showing inhibition of neutrophil hyperactivity in mice with antiphospholipid syndrome and lupus after injection with a purified ginger preparation.
• Researchers replicated the results showing effects of oral ginger on neutrophils in eight additional healthy adults who also showed reduced NETosis and increased cAMP after 1 week of ginger supplements.

IN PRACTICE:

The results show biologic support for the potential of ginger to affect neutrophil function in humans; therefore, “ginger may have a real ability to complement treatment programs that are already underway,” said corresponding author Jason Knight, MD, of the University of Michigan, Ann Arbor, in a press release.

SOURCE:

First author Ramadan A. Ali, MD, of the University of Michigan, Ann Arbor, and colleagues reported their study in JCI Insight.

LIMITATIONS:

More research is needed in humans with inflammatory and autoimmune diseases to confirm the findings and explore ginger as an adjuvant therapeutic intervention.

DISCLOSURES:

The study received no outside funding. The researchers report no relevant financial relationships.

A version of this article appeared on Medscape.com.

TOPLINE:

Blood samples from healthy adults show an inhibition of neutrophil extracellular trap formation (NET) after 1 week of daily ginger supplements.

METHODOLOGY:

• Researchers recruited nine healthy adults aged 18-38 years to receive a 100-mg oral ginger supplement daily for 7 consecutive days.
• Blood samples were collected at baseline and on days 7 and 14, with isolation of neutrophils, peripheral blood mononuclear cells, and plasma.
• The researchers measured NET formation (NETosis) as a way to show the effect of ginger on inflammation.

TAKEAWAY:

• Measures of neutrophil cyclic AMP (cAMP) were significantly higher after 7 days of ginger supplements, compared with baseline levels, although these levels returned to near baseline by 1 week after discontinuing ginger consumption.
• Oral ginger supplements reduced neutrophil phosphodiesterase (PDE) activity by 40% from baseline, similar to results seen with synthetic PDE4 inhibitors.
• The results build on previous studies showing inhibition of neutrophil hyperactivity in mice with antiphospholipid syndrome and lupus after injection with a purified ginger preparation.
• Researchers replicated the results showing effects of oral ginger on neutrophils in eight additional healthy adults who also showed reduced NETosis and increased cAMP after 1 week of ginger supplements.

IN PRACTICE:

The results show biologic support for the potential of ginger to affect neutrophil function in humans; therefore, “ginger may have a real ability to complement treatment programs that are already underway,” said corresponding author Jason Knight, MD, of the University of Michigan, Ann Arbor, in a press release.

SOURCE:

First author Ramadan A. Ali, MD, of the University of Michigan, Ann Arbor, and colleagues reported their study in JCI Insight.

LIMITATIONS:

More research is needed in humans with inflammatory and autoimmune diseases to confirm the findings and explore ginger as an adjuvant therapeutic intervention.

DISCLOSURES:

The study received no outside funding. The researchers report no relevant financial relationships.

A version of this article appeared on Medscape.com.

TOPLINE:

Blood samples from healthy adults show an inhibition of neutrophil extracellular trap formation (NET) after 1 week of daily ginger supplements.

METHODOLOGY:

• Researchers recruited nine healthy adults aged 18-38 years to receive a 100-mg oral ginger supplement daily for 7 consecutive days.
• Blood samples were collected at baseline and on days 7 and 14, with isolation of neutrophils, peripheral blood mononuclear cells, and plasma.
• The researchers measured NET formation (NETosis) as a way to show the effect of ginger on inflammation.

TAKEAWAY:

• Measures of neutrophil cyclic AMP (cAMP) were significantly higher after 7 days of ginger supplements, compared with baseline levels, although these levels returned to near baseline by 1 week after discontinuing ginger consumption.
• Oral ginger supplements reduced neutrophil phosphodiesterase (PDE) activity by 40% from baseline, similar to results seen with synthetic PDE4 inhibitors.
• The results build on previous studies showing inhibition of neutrophil hyperactivity in mice with antiphospholipid syndrome and lupus after injection with a purified ginger preparation.
• Researchers replicated the results showing effects of oral ginger on neutrophils in eight additional healthy adults who also showed reduced NETosis and increased cAMP after 1 week of ginger supplements.

IN PRACTICE:

The results show biologic support for the potential of ginger to affect neutrophil function in humans; therefore, “ginger may have a real ability to complement treatment programs that are already underway,” said corresponding author Jason Knight, MD, of the University of Michigan, Ann Arbor, in a press release.

SOURCE:

First author Ramadan A. Ali, MD, of the University of Michigan, Ann Arbor, and colleagues reported their study in JCI Insight.

LIMITATIONS:

More research is needed in humans with inflammatory and autoimmune diseases to confirm the findings and explore ginger as an adjuvant therapeutic intervention.

DISCLOSURES:

The study received no outside funding. The researchers report no relevant financial relationships.

A version of this article appeared on Medscape.com.

Key clinical point: Fremanezumab was effective as a preventive treatment in patients with chronic migraine (CM) with or without medication overuse (MO) and showed potential benefits in reducing MO.

Major finding: During a 12-week follow-up period, the administration of monthly and quarterly fremanezumab vs placebo led to significantly reduced average number of monthly headache days of moderate or greater severity in patients with MO (monthly: mean change [∆] −2.0, P = .0012; and quarterly: ∆ −1.8, P = .0042) and without MO (monthly: ∆ −1.6, P = .0437; and quarterly: ∆ −1.5, P = .0441). A greater proportion of patients receiving fremanezumab vs placebo reverted to no MO (P ≤ .05).

Study details: This post hoc analysis of a phase 2b/3 trial included 479 Japanese patients with CM who were randomly assigned to receive monthly fremanezumab (n = 159), quarterly fremanezumab (n = 159), or placebo (n = 161), and of whom 320 patients reported MO.

Disclosures: This study was funded by Otsuka Pharmaceutical Co., Ltd. Several authors declared being full-time employees of Otsuka Pharmaceutical Co., Ltd., and N Imai declared ties with various other sources.

Source: Imai N et al. Effects of fremanezumab on medication overuse in Japanese chronic migraine patients: Post hoc analysis of a multicenter, randomized, double-blind, placebo-controlled trial. Neurol Ther. 2023 (Sep 11). doi: 10.1007/s40120-023-00531-3

Key clinical point: Fremanezumab was effective as a preventive treatment in patients with chronic migraine (CM) with or without medication overuse (MO) and showed potential benefits in reducing MO.

Major finding: During a 12-week follow-up period, the administration of monthly and quarterly fremanezumab vs placebo led to significantly reduced average number of monthly headache days of moderate or greater severity in patients with MO (monthly: mean change [∆] −2.0, P = .0012; and quarterly: ∆ −1.8, P = .0042) and without MO (monthly: ∆ −1.6, P = .0437; and quarterly: ∆ −1.5, P = .0441). A greater proportion of patients receiving fremanezumab vs placebo reverted to no MO (P ≤ .05).

Study details: This post hoc analysis of a phase 2b/3 trial included 479 Japanese patients with CM who were randomly assigned to receive monthly fremanezumab (n = 159), quarterly fremanezumab (n = 159), or placebo (n = 161), and of whom 320 patients reported MO.

Disclosures: This study was funded by Otsuka Pharmaceutical Co., Ltd. Several authors declared being full-time employees of Otsuka Pharmaceutical Co., Ltd., and N Imai declared ties with various other sources.

Source: Imai N et al. Effects of fremanezumab on medication overuse in Japanese chronic migraine patients: Post hoc analysis of a multicenter, randomized, double-blind, placebo-controlled trial. Neurol Ther. 2023 (Sep 11). doi: 10.1007/s40120-023-00531-3

Key clinical point: Fremanezumab was effective as a preventive treatment in patients with chronic migraine (CM) with or without medication overuse (MO) and showed potential benefits in reducing MO.

Major finding: During a 12-week follow-up period, the administration of monthly and quarterly fremanezumab vs placebo led to significantly reduced average number of monthly headache days of moderate or greater severity in patients with MO (monthly: mean change [∆] −2.0, P = .0012; and quarterly: ∆ −1.8, P = .0042) and without MO (monthly: ∆ −1.6, P = .0437; and quarterly: ∆ −1.5, P = .0441). A greater proportion of patients receiving fremanezumab vs placebo reverted to no MO (P ≤ .05).

Study details: This post hoc analysis of a phase 2b/3 trial included 479 Japanese patients with CM who were randomly assigned to receive monthly fremanezumab (n = 159), quarterly fremanezumab (n = 159), or placebo (n = 161), and of whom 320 patients reported MO.

Disclosures: This study was funded by Otsuka Pharmaceutical Co., Ltd. Several authors declared being full-time employees of Otsuka Pharmaceutical Co., Ltd., and N Imai declared ties with various other sources.

Source: Imai N et al. Effects of fremanezumab on medication overuse in Japanese chronic migraine patients: Post hoc analysis of a multicenter, randomized, double-blind, placebo-controlled trial. Neurol Ther. 2023 (Sep 11). doi: 10.1007/s40120-023-00531-3

Key clinical point: Patients with migraine who achieved ≥ 50% reduction in headache days at 6 months (responders) with anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAb) showed an even greater reduction in the number of days per month with photophobia, phonophobia, and aura ratios.

Major finding: Monthly headache days reduced significantly by 9.4 days/month (P < .001) and 2.2 days/month (P = .004) among responders and non-responders, respectively, with responders having additional significant reductions in photophobia (−19.5%; P < .001), phonophobia (−12.1%; P = .010), and aura (−25.1%; P = .008) ratios. Higher basal photophobia ratios were predictors of increased response rates between months 3 and 6 (incidence risk ratio 0.928; P = .040).

Study details: This prospective observational study included 158 patients with migraine treated with anti-CGRP mAb, of whom 43.7% were responders.

Disclosures: This study did not receive any funding. A Alpuente, E Caronna, M Torres-Ferrús, and P Pozo-Rosich declared receiving honoraria as consultants or speakers from various sources.

Source: Alpuente A et al. Impact of anti-CGRP monoclonal antibodies on migraine attack accompanying symptoms: A real-world evidence study. Cephalalgia. 2023;43(8):3331024231177636 (Aug 9). doi: 10.1177/03331024231177636

Key clinical point: Patients with migraine who achieved ≥ 50% reduction in headache days at 6 months (responders) with anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAb) showed an even greater reduction in the number of days per month with photophobia, phonophobia, and aura ratios.

Major finding: Monthly headache days reduced significantly by 9.4 days/month (P < .001) and 2.2 days/month (P = .004) among responders and non-responders, respectively, with responders having additional significant reductions in photophobia (−19.5%; P < .001), phonophobia (−12.1%; P = .010), and aura (−25.1%; P = .008) ratios. Higher basal photophobia ratios were predictors of increased response rates between months 3 and 6 (incidence risk ratio 0.928; P = .040).

Study details: This prospective observational study included 158 patients with migraine treated with anti-CGRP mAb, of whom 43.7% were responders.

Disclosures: This study did not receive any funding. A Alpuente, E Caronna, M Torres-Ferrús, and P Pozo-Rosich declared receiving honoraria as consultants or speakers from various sources.

Source: Alpuente A et al. Impact of anti-CGRP monoclonal antibodies on migraine attack accompanying symptoms: A real-world evidence study. Cephalalgia. 2023;43(8):3331024231177636 (Aug 9). doi: 10.1177/03331024231177636

Key clinical point: Patients with migraine who achieved ≥ 50% reduction in headache days at 6 months (responders) with anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAb) showed an even greater reduction in the number of days per month with photophobia, phonophobia, and aura ratios.

Major finding: Monthly headache days reduced significantly by 9.4 days/month (P < .001) and 2.2 days/month (P = .004) among responders and non-responders, respectively, with responders having additional significant reductions in photophobia (−19.5%; P < .001), phonophobia (−12.1%; P = .010), and aura (−25.1%; P = .008) ratios. Higher basal photophobia ratios were predictors of increased response rates between months 3 and 6 (incidence risk ratio 0.928; P = .040).

Study details: This prospective observational study included 158 patients with migraine treated with anti-CGRP mAb, of whom 43.7% were responders.

Disclosures: This study did not receive any funding. A Alpuente, E Caronna, M Torres-Ferrús, and P Pozo-Rosich declared receiving honoraria as consultants or speakers from various sources.

Source: Alpuente A et al. Impact of anti-CGRP monoclonal antibodies on migraine attack accompanying symptoms: A real-world evidence study. Cephalalgia. 2023;43(8):3331024231177636 (Aug 9). doi: 10.1177/03331024231177636

Key clinical point: No appreciable association was observed between a history of migraine or its subtypes and an increase in the risk for COVID-19, including hospitalization for COVID-19, in older women.

Major finding: No significant association was observed between a history of migraine and the risk of developing COVID-19 (odds ratio [OR] 1.08; 95% CI 0.95-1.22) or being hospitalized for COVID-19 (OR 1.20; 95% CI 0.86-1.68) among older women. Similarly, other migraine statuses, including migraine with aura, showed no association with the risk for COVID-19.

Study details: This prospective cohort study included 16,492 women (age ≥ 45 years) enrolled in the Women’s Health Study, of whom 28.9% had a history of migraine and 7.7% reported positive SARS-CoV-2 test results, a diagnosis of COVID-19, or hospitalization for COVID-19.

Disclosures: The Women’s Health Study was funded by grants from the US National Cancer Institute and the US National Heart, Lung, and Blood Institute. T Kurth declared receiving research grants and personal compensation from various sources. The other authors declared no conflicts of interest.

Source: Rist PM et al. History of migraine and risk of COVID-19: A cohort study. Am J Med. 2023 (Aug 18). doi: 10.1016/j.amjmed.2023.07.021

Key clinical point: No appreciable association was observed between a history of migraine or its subtypes and an increase in the risk for COVID-19, including hospitalization for COVID-19, in older women.

Major finding: No significant association was observed between a history of migraine and the risk of developing COVID-19 (odds ratio [OR] 1.08; 95% CI 0.95-1.22) or being hospitalized for COVID-19 (OR 1.20; 95% CI 0.86-1.68) among older women. Similarly, other migraine statuses, including migraine with aura, showed no association with the risk for COVID-19.

Study details: This prospective cohort study included 16,492 women (age ≥ 45 years) enrolled in the Women’s Health Study, of whom 28.9% had a history of migraine and 7.7% reported positive SARS-CoV-2 test results, a diagnosis of COVID-19, or hospitalization for COVID-19.

Disclosures: The Women’s Health Study was funded by grants from the US National Cancer Institute and the US National Heart, Lung, and Blood Institute. T Kurth declared receiving research grants and personal compensation from various sources. The other authors declared no conflicts of interest.

Source: Rist PM et al. History of migraine and risk of COVID-19: A cohort study. Am J Med. 2023 (Aug 18). doi: 10.1016/j.amjmed.2023.07.021

Key clinical point: No appreciable association was observed between a history of migraine or its subtypes and an increase in the risk for COVID-19, including hospitalization for COVID-19, in older women.

Major finding: No significant association was observed between a history of migraine and the risk of developing COVID-19 (odds ratio [OR] 1.08; 95% CI 0.95-1.22) or being hospitalized for COVID-19 (OR 1.20; 95% CI 0.86-1.68) among older women. Similarly, other migraine statuses, including migraine with aura, showed no association with the risk for COVID-19.

Study details: This prospective cohort study included 16,492 women (age ≥ 45 years) enrolled in the Women’s Health Study, of whom 28.9% had a history of migraine and 7.7% reported positive SARS-CoV-2 test results, a diagnosis of COVID-19, or hospitalization for COVID-19.

Disclosures: The Women’s Health Study was funded by grants from the US National Cancer Institute and the US National Heart, Lung, and Blood Institute. T Kurth declared receiving research grants and personal compensation from various sources. The other authors declared no conflicts of interest.

Source: Rist PM et al. History of migraine and risk of COVID-19: A cohort study. Am J Med. 2023 (Aug 18). doi: 10.1016/j.amjmed.2023.07.021

Key clinical point: Nearly 24% of patients with multiple sclerosis (MS) experience migraine, with the odds of migraine occurrence being approximately 2-fold higher in patients with MS compared with control individuals.

Major finding: The overall prevalence rate of migraine among patients with MS was 0.24 (95% CI 0.21-0.28). Moreover, patients with MS vs control participants without MS had a ~2-fold greater risk of experiencing migraine (odds ratio 1.96; 95% CI 1.20-3.20).

Study details: This meta-analysis of 35 studies included 279,620 patients with MS and 279,603 control participants without MS.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Mohammadi M et al. The association between multiple sclerosis and migraine: A meta-analysis. Mult Scler Relat Disord. 2023;79:104954 (Aug 30). doi: 10.1016/j.msard.2023.104954

Key clinical point: Nearly 24% of patients with multiple sclerosis (MS) experience migraine, with the odds of migraine occurrence being approximately 2-fold higher in patients with MS compared with control individuals.

Major finding: The overall prevalence rate of migraine among patients with MS was 0.24 (95% CI 0.21-0.28). Moreover, patients with MS vs control participants without MS had a ~2-fold greater risk of experiencing migraine (odds ratio 1.96; 95% CI 1.20-3.20).

Study details: This meta-analysis of 35 studies included 279,620 patients with MS and 279,603 control participants without MS.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Mohammadi M et al. The association between multiple sclerosis and migraine: A meta-analysis. Mult Scler Relat Disord. 2023;79:104954 (Aug 30). doi: 10.1016/j.msard.2023.104954

Key clinical point: Nearly 24% of patients with multiple sclerosis (MS) experience migraine, with the odds of migraine occurrence being approximately 2-fold higher in patients with MS compared with control individuals.

Major finding: The overall prevalence rate of migraine among patients with MS was 0.24 (95% CI 0.21-0.28). Moreover, patients with MS vs control participants without MS had a ~2-fold greater risk of experiencing migraine (odds ratio 1.96; 95% CI 1.20-3.20).

Study details: This meta-analysis of 35 studies included 279,620 patients with MS and 279,603 control participants without MS.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Mohammadi M et al. The association between multiple sclerosis and migraine: A meta-analysis. Mult Scler Relat Disord. 2023;79:104954 (Aug 30). doi: 10.1016/j.msard.2023.104954

Key clinical point: Absence of cutaneous allodynia was a predictor of treatment response following withdrawal therapy in patients with chronic migraine and medication overuse, with the predictive value being even more pronounced when compared with cephalic or extracephalic allodynia.

Major finding: The chances of reversion from chronic to episodic migraine were ~2.5 times higher in patients without vs with cutaneous allodynia (odds ratio [OR] 2.45; P = .042), with the predictive values of absence of allodynia being even more pronounced when compared with patients having cephalic (OR 4.16; P = .024) or extracephalic (OR 7.32; P = .003) allodynia.

Study details: This study, conducted as part of the Chronification And Reversibility of Migraine study, included 173 patients with chronic migraine and medication overuse, of whom 129 had cutaneous allodynia.

Disclosures: This study was supported by grants from the Netherlands Organization for Scientific Research and the Dutch Brain Foundation. I de Boer and GM Terwindt declared receiving independent support, consultancy support, or both from various sources.

Source: Pijpers JA et al. Cutaneous allodynia as predictor for treatment response in chronic migraine: A cohort study. J Headache Pain. 2023;24:118 (Aug 30). Doi: 10.1186/s10194-023-01651-9.

Key clinical point: Absence of cutaneous allodynia was a predictor of treatment response following withdrawal therapy in patients with chronic migraine and medication overuse, with the predictive value being even more pronounced when compared with cephalic or extracephalic allodynia.

Major finding: The chances of reversion from chronic to episodic migraine were ~2.5 times higher in patients without vs with cutaneous allodynia (odds ratio [OR] 2.45; P = .042), with the predictive values of absence of allodynia being even more pronounced when compared with patients having cephalic (OR 4.16; P = .024) or extracephalic (OR 7.32; P = .003) allodynia.

Study details: This study, conducted as part of the Chronification And Reversibility of Migraine study, included 173 patients with chronic migraine and medication overuse, of whom 129 had cutaneous allodynia.

Disclosures: This study was supported by grants from the Netherlands Organization for Scientific Research and the Dutch Brain Foundation. I de Boer and GM Terwindt declared receiving independent support, consultancy support, or both from various sources.

Source: Pijpers JA et al. Cutaneous allodynia as predictor for treatment response in chronic migraine: A cohort study. J Headache Pain. 2023;24:118 (Aug 30). Doi: 10.1186/s10194-023-01651-9.

Key clinical point: Absence of cutaneous allodynia was a predictor of treatment response following withdrawal therapy in patients with chronic migraine and medication overuse, with the predictive value being even more pronounced when compared with cephalic or extracephalic allodynia.

Major finding: The chances of reversion from chronic to episodic migraine were ~2.5 times higher in patients without vs with cutaneous allodynia (odds ratio [OR] 2.45; P = .042), with the predictive values of absence of allodynia being even more pronounced when compared with patients having cephalic (OR 4.16; P = .024) or extracephalic (OR 7.32; P = .003) allodynia.

Study details: This study, conducted as part of the Chronification And Reversibility of Migraine study, included 173 patients with chronic migraine and medication overuse, of whom 129 had cutaneous allodynia.

Disclosures: This study was supported by grants from the Netherlands Organization for Scientific Research and the Dutch Brain Foundation. I de Boer and GM Terwindt declared receiving independent support, consultancy support, or both from various sources.

Source: Pijpers JA et al. Cutaneous allodynia as predictor for treatment response in chronic migraine: A cohort study. J Headache Pain. 2023;24:118 (Aug 30). Doi: 10.1186/s10194-023-01651-9.

Key clinical point: A history of migraine was significantly associated with an increased risk for cervical artery dissection (CeAD), with the risk being predominantly driven by migraine without aura.

Major finding: The risk for CeAD was 1.74-fold higher in patients with vs without migraine (adjusted odds ratio [aOR] 1.74; 95% CI 1.38-2.19), with the risk being pronounced in migraine without aura (aOR 1.86; 95% CI 1.55-2.24) but not in migraine with aura (aOR 1.15; 95% CI 0.71-1.88).

Study details: This meta-analysis included 11 case-control studies with 2188 CeAD cases and 7669 control participants.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Sun Z et al. Migraine and the risk of cervical artery dissection: A systematic review and meta-analysis. Eur Stroke J. 2023 (Aug 9). doi: 10.1177/23969873231191860

Key clinical point: A history of migraine was significantly associated with an increased risk for cervical artery dissection (CeAD), with the risk being predominantly driven by migraine without aura.

Major finding: The risk for CeAD was 1.74-fold higher in patients with vs without migraine (adjusted odds ratio [aOR] 1.74; 95% CI 1.38-2.19), with the risk being pronounced in migraine without aura (aOR 1.86; 95% CI 1.55-2.24) but not in migraine with aura (aOR 1.15; 95% CI 0.71-1.88).

Study details: This meta-analysis included 11 case-control studies with 2188 CeAD cases and 7669 control participants.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Sun Z et al. Migraine and the risk of cervical artery dissection: A systematic review and meta-analysis. Eur Stroke J. 2023 (Aug 9). doi: 10.1177/23969873231191860

Key clinical point: A history of migraine was significantly associated with an increased risk for cervical artery dissection (CeAD), with the risk being predominantly driven by migraine without aura.

Major finding: The risk for CeAD was 1.74-fold higher in patients with vs without migraine (adjusted odds ratio [aOR] 1.74; 95% CI 1.38-2.19), with the risk being pronounced in migraine without aura (aOR 1.86; 95% CI 1.55-2.24) but not in migraine with aura (aOR 1.15; 95% CI 0.71-1.88).

Study details: This meta-analysis included 11 case-control studies with 2188 CeAD cases and 7669 control participants.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Sun Z et al. Migraine and the risk of cervical artery dissection: A systematic review and meta-analysis. Eur Stroke J. 2023 (Aug 9). doi: 10.1177/23969873231191860

Key clinical point: Early wearing-off effect (WOE) is common in patients with chronic migraine (CM) receiving onabotulinumtoxinA (OnabotA) and more frequent after the first cycle of OnabotA, with depression and anxiety disorders being clinical predictors of the WOE.

Major finding: Early WOE was reported more frequently after the first vs second treatment cycle of OnabotA (35.6% vs 23.8% of patients), with depression and anxiety disorders being significant clinical predictors of WOE (odds ratio 3.4; 95% CI 1.22-10.84; P = .028).

Study details: Findings are from a prospective real-life study including 59 patients with CM and insufficient response, absence of tolerability, or contraindications to previous migraine therapies who initiated prophylactic treatment with OnabotA, 40.6% of whom reported a WOE.

Disclosures: This study received no external funding. The authors declared no conflicts of interest.

Source: Rodríguez-Montolio J et al. Early wearing-off effect of OnabotulinumtoxinA in chronic migraine: A prospective real-life study. J Clin Med. 2023;12(16):5360 (Aug 17). doi: 10.3390/jcm12165360

Key clinical point: Early wearing-off effect (WOE) is common in patients with chronic migraine (CM) receiving onabotulinumtoxinA (OnabotA) and more frequent after the first cycle of OnabotA, with depression and anxiety disorders being clinical predictors of the WOE.

Major finding: Early WOE was reported more frequently after the first vs second treatment cycle of OnabotA (35.6% vs 23.8% of patients), with depression and anxiety disorders being significant clinical predictors of WOE (odds ratio 3.4; 95% CI 1.22-10.84; P = .028).

Study details: Findings are from a prospective real-life study including 59 patients with CM and insufficient response, absence of tolerability, or contraindications to previous migraine therapies who initiated prophylactic treatment with OnabotA, 40.6% of whom reported a WOE.

Disclosures: This study received no external funding. The authors declared no conflicts of interest.

Source: Rodríguez-Montolio J et al. Early wearing-off effect of OnabotulinumtoxinA in chronic migraine: A prospective real-life study. J Clin Med. 2023;12(16):5360 (Aug 17). doi: 10.3390/jcm12165360

Key clinical point: Early wearing-off effect (WOE) is common in patients with chronic migraine (CM) receiving onabotulinumtoxinA (OnabotA) and more frequent after the first cycle of OnabotA, with depression and anxiety disorders being clinical predictors of the WOE.

Major finding: Early WOE was reported more frequently after the first vs second treatment cycle of OnabotA (35.6% vs 23.8% of patients), with depression and anxiety disorders being significant clinical predictors of WOE (odds ratio 3.4; 95% CI 1.22-10.84; P = .028).

Study details: Findings are from a prospective real-life study including 59 patients with CM and insufficient response, absence of tolerability, or contraindications to previous migraine therapies who initiated prophylactic treatment with OnabotA, 40.6% of whom reported a WOE.

Disclosures: This study received no external funding. The authors declared no conflicts of interest.

Source: Rodríguez-Montolio J et al. Early wearing-off effect of OnabotulinumtoxinA in chronic migraine: A prospective real-life study. J Clin Med. 2023;12(16):5360 (Aug 17). doi: 10.3390/jcm12165360

Key clinical point: Ubrogepant shows similar efficacy and no new safety concerns for the treatment of perimenstrual migraine (pmM) and non-pmM attacks.

Major finding: At 2 hours post dose, pain freedom (P = .054) and pain relief (P = .683) were similar between pmM and non-pmM attacks treated with 50 mg ubrogepant. Absence of migraine-associated symptoms (photophobia and phonophobia) and functional disability was not significantly different between pmM and non-pmM attacks treated with 50 mg ubrogepant, with similar findings observed for 100 mg ubrogepant. Nausea and dizziness were reported in < 6% of participants overall in both the 50 mg and 100 mg ubrogepant groups.

Study details: This post hoc analysis of a long-term safety extension trial included 734 women with migraine, of whom 278 and 716 were treated with ubrogepant (50 mg or 100 mg) for ≥ 1 pmM and non-pmM attacks, respectively.

Disclosures: This study was funded by Allergan (prior to its acquisition by AbbVie). Four authors declared being employees of or holding stocks in AbbVie, and the other authors declared ties with various sources, including AbbVie.

Source: MacGregor EA et al. Safety and efficacy of ubrogepant for the acute treatment of perimenstrual migraine attacks: A post hoc analysis. Headache. 2023 (Sep 1). doi: 10.1111/head.14619

Key clinical point: Ubrogepant shows similar efficacy and no new safety concerns for the treatment of perimenstrual migraine (pmM) and non-pmM attacks.

Major finding: At 2 hours post dose, pain freedom (P = .054) and pain relief (P = .683) were similar between pmM and non-pmM attacks treated with 50 mg ubrogepant. Absence of migraine-associated symptoms (photophobia and phonophobia) and functional disability was not significantly different between pmM and non-pmM attacks treated with 50 mg ubrogepant, with similar findings observed for 100 mg ubrogepant. Nausea and dizziness were reported in < 6% of participants overall in both the 50 mg and 100 mg ubrogepant groups.

Study details: This post hoc analysis of a long-term safety extension trial included 734 women with migraine, of whom 278 and 716 were treated with ubrogepant (50 mg or 100 mg) for ≥ 1 pmM and non-pmM attacks, respectively.

Disclosures: This study was funded by Allergan (prior to its acquisition by AbbVie). Four authors declared being employees of or holding stocks in AbbVie, and the other authors declared ties with various sources, including AbbVie.

Source: MacGregor EA et al. Safety and efficacy of ubrogepant for the acute treatment of perimenstrual migraine attacks: A post hoc analysis. Headache. 2023 (Sep 1). doi: 10.1111/head.14619

Key clinical point: Ubrogepant shows similar efficacy and no new safety concerns for the treatment of perimenstrual migraine (pmM) and non-pmM attacks.

Major finding: At 2 hours post dose, pain freedom (P = .054) and pain relief (P = .683) were similar between pmM and non-pmM attacks treated with 50 mg ubrogepant. Absence of migraine-associated symptoms (photophobia and phonophobia) and functional disability was not significantly different between pmM and non-pmM attacks treated with 50 mg ubrogepant, with similar findings observed for 100 mg ubrogepant. Nausea and dizziness were reported in < 6% of participants overall in both the 50 mg and 100 mg ubrogepant groups.

Study details: This post hoc analysis of a long-term safety extension trial included 734 women with migraine, of whom 278 and 716 were treated with ubrogepant (50 mg or 100 mg) for ≥ 1 pmM and non-pmM attacks, respectively.

Disclosures: This study was funded by Allergan (prior to its acquisition by AbbVie). Four authors declared being employees of or holding stocks in AbbVie, and the other authors declared ties with various sources, including AbbVie.

Source: MacGregor EA et al. Safety and efficacy of ubrogepant for the acute treatment of perimenstrual migraine attacks: A post hoc analysis. Headache. 2023 (Sep 1). doi: 10.1111/head.14619