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Activities of Daily Living

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Activities of daily living: Ah, that fall!

Tears well up in my eyes. Not from pain, but frustration.

I pleaded with my 3‐year‐olds to come to me, so I could help them wash and dress for the day. Ordinarily, I would have come into their room, leaned over their beds, and whispered good morning into their ears.

Four days after surgery, I wasn't able to do that. Not without the crutches. Even with the crutches, I was moving slowly. I scooted up, put a few pillows behind my back, and carefully lifted up my leg. Putting on the knee immobilizer would take too long; I would only be crossing the hall.

Weighing less than 800 g, the immobilizer is an adjustable aluminum frame attached to foam rubber and 4 wide Velcro straps. It is a device of torment. I can never seem to find the proper fit. If it is too tight, my leg hurts and starts turning blue. When it is too loose, it pulls on my incision, multiplying the pain. You put it on while sitting, but you only discover whether it is too tight or too loose when you stand up.

With one foot on the floor at the edge of the bed, I took one crutch in hand, shifted to the left, and grabbed for the other crutch. I squeezed the handgrips of the crutches tightly and pulled myself up.

Put your weight on your hands, NOT your armpits, the instructions said. Easier said than done, because my armpits were now sore too.

Keep your crutches even with each other. I tried to remember to make an equilateral triangle with my good foot and 2 crutches, but the instructions only seemed to account for movement in a straight line.

Keep your elbows slightly bent and close to your sides to help keep the crutches under your arm. I am trying that too.

Lock your elbows. This instruction contradicts the previous one. Which should I follow?

Place your crutches 2 to 3 inches outside of each foot. How do I do this and keep my elbows close to my sides?

Swing your injured leg through first. But not too much, or I'll pole vault across the room.

After 3 steps, my leg started to throb, and my quadriceps went into a spasm. I needed to sit down, immediately.

Non‐weight‐bearing for next 4 weeks, was written on the doctor's note. Four weeks feels like an eternity. If my heel or toe even touched the ground, I felt an immediate throb of pain in my knee.

How do my orthopedic patients do it: those with broken hips and bad or broken knees, with hip replacements, or knee replacements? I was sensitive to their pain and could optimize control. Postoperatively, I could support gastrointestinal and other organ systems. I made sure that the basic weight‐bearing order was correct. I carefully followed the physical and/or occupational therapy recommendation for home, rehabilitation, or a nursing home. I spoke with families. Yet I did not dwell on activities of daily living nor how my patients felt to be dependent on others for simple things they needed. Some patients were non‐weight‐bearing for weeks, some for months, others never walked again. How can one deeply understand it if one has never experienced it?

According to Centers for Disease Control and Prevention (CDC) statistics,1 unintentional injuries are the leading cause of death between the ages of 1 and 44 years. Accidents are again the leading cause of death after age 75 years. More startling is the fact that these numbers have not been significantly reduced since these data were first collected. Nor do these numbers reveal the number of those debilitated, but still living. In my case, I was not playing basketball, water skiing, or rock climbing: I slipped and fell while stepping into a wading pool with my children, severing ligaments, tearing meniscus, and creating a hairline fracture of my tibia.

Expect to move slowly with the crutches. Yes, I am moving very slowly, only 1 to 2 feet with each stride. If I take a longer stride, I lose my balance.

Learn to sit down with the crutches. Learn to stand up. Learn to get into a car.

Learn to go up the stairs. Learn to go down the stairs.

Avoid wet surfaces. Otherwise you'll start skating and reinjure that knee.

It was effortless to think of patients and colleagues of mine. Mr. S., how do you do it? At age 30 years, he was quadriplegic from falling from a tree as a teenager. Mr. D, how about you, in a wheelchair, after being hit by a car and multiple postoperative leg infections and amputations: living in hotels, with estranged family and no social support. How did you do it, while we nagged you about controlling your glucose. Dr. J? The sadness fills my heart. At only 60 years old, my wonderful professor now made rounds in an electric wheelchair, the victim of amyotrophic lateral sclerosis (ALS). My fate, in comparison, is fortunate; my immobility only temporary. I can still think. And talk. And use a phone. And eat, as well as write this essay. And, best of all, read stories to my children. Be careful about this leg, I remind them. Don't come too close!

Maybe what life is trying to tell you is, slow down. In fact, it's forcing you to do that, a colleague and friend said. I had prided myself in thorough and compassionate doctoring. Now, having been a patient on crutches, I have a greater understanding of how limits to mobility can impact daily living on my patients after I discharge them. And the mundane subject of accident prevention has gained a new urgency.

References
  1. Kung HC,Hoyert DL,Xu J,Murphy SL.Deaths: final data for 2005.Natl Vital Stat Rep.2008;56(10):1120.
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Issue
Journal of Hospital Medicine - 5(1)
Publications
Page Number
60-61
Legacy Keywords
activities of daily living, limited mobility, injured, prevention
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Article PDF
Article PDF

Tears well up in my eyes. Not from pain, but frustration.

I pleaded with my 3‐year‐olds to come to me, so I could help them wash and dress for the day. Ordinarily, I would have come into their room, leaned over their beds, and whispered good morning into their ears.

Four days after surgery, I wasn't able to do that. Not without the crutches. Even with the crutches, I was moving slowly. I scooted up, put a few pillows behind my back, and carefully lifted up my leg. Putting on the knee immobilizer would take too long; I would only be crossing the hall.

Weighing less than 800 g, the immobilizer is an adjustable aluminum frame attached to foam rubber and 4 wide Velcro straps. It is a device of torment. I can never seem to find the proper fit. If it is too tight, my leg hurts and starts turning blue. When it is too loose, it pulls on my incision, multiplying the pain. You put it on while sitting, but you only discover whether it is too tight or too loose when you stand up.

With one foot on the floor at the edge of the bed, I took one crutch in hand, shifted to the left, and grabbed for the other crutch. I squeezed the handgrips of the crutches tightly and pulled myself up.

Put your weight on your hands, NOT your armpits, the instructions said. Easier said than done, because my armpits were now sore too.

Keep your crutches even with each other. I tried to remember to make an equilateral triangle with my good foot and 2 crutches, but the instructions only seemed to account for movement in a straight line.

Keep your elbows slightly bent and close to your sides to help keep the crutches under your arm. I am trying that too.

Lock your elbows. This instruction contradicts the previous one. Which should I follow?

Place your crutches 2 to 3 inches outside of each foot. How do I do this and keep my elbows close to my sides?

Swing your injured leg through first. But not too much, or I'll pole vault across the room.

After 3 steps, my leg started to throb, and my quadriceps went into a spasm. I needed to sit down, immediately.

Non‐weight‐bearing for next 4 weeks, was written on the doctor's note. Four weeks feels like an eternity. If my heel or toe even touched the ground, I felt an immediate throb of pain in my knee.

How do my orthopedic patients do it: those with broken hips and bad or broken knees, with hip replacements, or knee replacements? I was sensitive to their pain and could optimize control. Postoperatively, I could support gastrointestinal and other organ systems. I made sure that the basic weight‐bearing order was correct. I carefully followed the physical and/or occupational therapy recommendation for home, rehabilitation, or a nursing home. I spoke with families. Yet I did not dwell on activities of daily living nor how my patients felt to be dependent on others for simple things they needed. Some patients were non‐weight‐bearing for weeks, some for months, others never walked again. How can one deeply understand it if one has never experienced it?

According to Centers for Disease Control and Prevention (CDC) statistics,1 unintentional injuries are the leading cause of death between the ages of 1 and 44 years. Accidents are again the leading cause of death after age 75 years. More startling is the fact that these numbers have not been significantly reduced since these data were first collected. Nor do these numbers reveal the number of those debilitated, but still living. In my case, I was not playing basketball, water skiing, or rock climbing: I slipped and fell while stepping into a wading pool with my children, severing ligaments, tearing meniscus, and creating a hairline fracture of my tibia.

Expect to move slowly with the crutches. Yes, I am moving very slowly, only 1 to 2 feet with each stride. If I take a longer stride, I lose my balance.

Learn to sit down with the crutches. Learn to stand up. Learn to get into a car.

Learn to go up the stairs. Learn to go down the stairs.

Avoid wet surfaces. Otherwise you'll start skating and reinjure that knee.

It was effortless to think of patients and colleagues of mine. Mr. S., how do you do it? At age 30 years, he was quadriplegic from falling from a tree as a teenager. Mr. D, how about you, in a wheelchair, after being hit by a car and multiple postoperative leg infections and amputations: living in hotels, with estranged family and no social support. How did you do it, while we nagged you about controlling your glucose. Dr. J? The sadness fills my heart. At only 60 years old, my wonderful professor now made rounds in an electric wheelchair, the victim of amyotrophic lateral sclerosis (ALS). My fate, in comparison, is fortunate; my immobility only temporary. I can still think. And talk. And use a phone. And eat, as well as write this essay. And, best of all, read stories to my children. Be careful about this leg, I remind them. Don't come too close!

Maybe what life is trying to tell you is, slow down. In fact, it's forcing you to do that, a colleague and friend said. I had prided myself in thorough and compassionate doctoring. Now, having been a patient on crutches, I have a greater understanding of how limits to mobility can impact daily living on my patients after I discharge them. And the mundane subject of accident prevention has gained a new urgency.

Tears well up in my eyes. Not from pain, but frustration.

I pleaded with my 3‐year‐olds to come to me, so I could help them wash and dress for the day. Ordinarily, I would have come into their room, leaned over their beds, and whispered good morning into their ears.

Four days after surgery, I wasn't able to do that. Not without the crutches. Even with the crutches, I was moving slowly. I scooted up, put a few pillows behind my back, and carefully lifted up my leg. Putting on the knee immobilizer would take too long; I would only be crossing the hall.

Weighing less than 800 g, the immobilizer is an adjustable aluminum frame attached to foam rubber and 4 wide Velcro straps. It is a device of torment. I can never seem to find the proper fit. If it is too tight, my leg hurts and starts turning blue. When it is too loose, it pulls on my incision, multiplying the pain. You put it on while sitting, but you only discover whether it is too tight or too loose when you stand up.

With one foot on the floor at the edge of the bed, I took one crutch in hand, shifted to the left, and grabbed for the other crutch. I squeezed the handgrips of the crutches tightly and pulled myself up.

Put your weight on your hands, NOT your armpits, the instructions said. Easier said than done, because my armpits were now sore too.

Keep your crutches even with each other. I tried to remember to make an equilateral triangle with my good foot and 2 crutches, but the instructions only seemed to account for movement in a straight line.

Keep your elbows slightly bent and close to your sides to help keep the crutches under your arm. I am trying that too.

Lock your elbows. This instruction contradicts the previous one. Which should I follow?

Place your crutches 2 to 3 inches outside of each foot. How do I do this and keep my elbows close to my sides?

Swing your injured leg through first. But not too much, or I'll pole vault across the room.

After 3 steps, my leg started to throb, and my quadriceps went into a spasm. I needed to sit down, immediately.

Non‐weight‐bearing for next 4 weeks, was written on the doctor's note. Four weeks feels like an eternity. If my heel or toe even touched the ground, I felt an immediate throb of pain in my knee.

How do my orthopedic patients do it: those with broken hips and bad or broken knees, with hip replacements, or knee replacements? I was sensitive to their pain and could optimize control. Postoperatively, I could support gastrointestinal and other organ systems. I made sure that the basic weight‐bearing order was correct. I carefully followed the physical and/or occupational therapy recommendation for home, rehabilitation, or a nursing home. I spoke with families. Yet I did not dwell on activities of daily living nor how my patients felt to be dependent on others for simple things they needed. Some patients were non‐weight‐bearing for weeks, some for months, others never walked again. How can one deeply understand it if one has never experienced it?

According to Centers for Disease Control and Prevention (CDC) statistics,1 unintentional injuries are the leading cause of death between the ages of 1 and 44 years. Accidents are again the leading cause of death after age 75 years. More startling is the fact that these numbers have not been significantly reduced since these data were first collected. Nor do these numbers reveal the number of those debilitated, but still living. In my case, I was not playing basketball, water skiing, or rock climbing: I slipped and fell while stepping into a wading pool with my children, severing ligaments, tearing meniscus, and creating a hairline fracture of my tibia.

Expect to move slowly with the crutches. Yes, I am moving very slowly, only 1 to 2 feet with each stride. If I take a longer stride, I lose my balance.

Learn to sit down with the crutches. Learn to stand up. Learn to get into a car.

Learn to go up the stairs. Learn to go down the stairs.

Avoid wet surfaces. Otherwise you'll start skating and reinjure that knee.

It was effortless to think of patients and colleagues of mine. Mr. S., how do you do it? At age 30 years, he was quadriplegic from falling from a tree as a teenager. Mr. D, how about you, in a wheelchair, after being hit by a car and multiple postoperative leg infections and amputations: living in hotels, with estranged family and no social support. How did you do it, while we nagged you about controlling your glucose. Dr. J? The sadness fills my heart. At only 60 years old, my wonderful professor now made rounds in an electric wheelchair, the victim of amyotrophic lateral sclerosis (ALS). My fate, in comparison, is fortunate; my immobility only temporary. I can still think. And talk. And use a phone. And eat, as well as write this essay. And, best of all, read stories to my children. Be careful about this leg, I remind them. Don't come too close!

Maybe what life is trying to tell you is, slow down. In fact, it's forcing you to do that, a colleague and friend said. I had prided myself in thorough and compassionate doctoring. Now, having been a patient on crutches, I have a greater understanding of how limits to mobility can impact daily living on my patients after I discharge them. And the mundane subject of accident prevention has gained a new urgency.

References
  1. Kung HC,Hoyert DL,Xu J,Murphy SL.Deaths: final data for 2005.Natl Vital Stat Rep.2008;56(10):1120.
References
  1. Kung HC,Hoyert DL,Xu J,Murphy SL.Deaths: final data for 2005.Natl Vital Stat Rep.2008;56(10):1120.
Issue
Journal of Hospital Medicine - 5(1)
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Journal of Hospital Medicine - 5(1)
Page Number
60-61
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60-61
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Activities of daily living: Ah, that fall!
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Activities of daily living: Ah, that fall!
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Department of Medical Education, Director of Inpatient Teaching Services, Associate Residency Program Director, St. Mary Medical Center, 1050 Linden Ave, Long Beach, CA 90813
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A New Perspective

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A new perspective

I lay tossing and turning in the uncomfortable bed; the strange room with cables and stands strewn everywhere was very familiar but at the same time alien to me. I lay there thinking how I ended up here. Only a few short weeks ago I was on my way to a successful career as a hospitalist. I had just finished my chief residency, confident in my skills as a clinician. I considered myself to be a strong patient advocate and felt proud of the fact that I kept the patient above everything else. But I had no inkling of what the future had in store for me. I was not supposed to be a patient, I was young and healthy; surely this had to be a mistake. I realized that I just wasn't ready to handle the situation from the other side!

My nightmare started about a week before, when I woke up with excruciating abdominal pain, too weak to even call out for help. I eventually mustered enough strength to call Emergency Medical Services (EMS), the differential diagnosis of my symptoms going through my head. Surely I had perforated an ulcer! The increased proton pump inhibitor consumption wasn't just because of the rigors of the chief residency.

At the triage station, I could see the nurse looking at me, I knew that look, Great! She thinks I am a pain medication seeker. Even though it was a rude awakening, I realized I was disheveled, unkempt, and looked like anyone else on the street. Between spasms of pain and nursing my bruised ego, I blurted out, Can I have something for this pain!? I can't take it any more. All I got back was a blank stare and a dry, We will have to wait till the doctor sees you.

The Emergency Room (ER) physician recognized me as one of the new hospitalists. The demeanor of the staff changed perceptibly; I got the pain medications and the nurses paid close attention to my overall comfort. A battery of tests was ordered and an abdominal computed tomography (CT) scan revealed acute cholecystitis. I underwent an emergent cholecystectomy. On the third postoperative day I developed a nonproductive cough. The fever started within the next 24 hours. A CT scan revealed a large left lower lobe pneumonia.

God, why is this happening to me? I was in a daze while arrangements were being made to admit me. It was a different hospital, but here the treatment from the nurses was completely different. They had known me for almost 4 years, and had followed my progress from a green, wet‐behind‐the‐ears intern, to a chief resident, and eventually to an attending physician. Over the years they had learned to trust and respect me, but more importantly they had a bond with me that had developed over the years. This familiarity affected their interaction with me in this different role. I was astonished by how different our behaviors can be, based on our perception of the patient. As medical professionals we want to think that we look at people through the same lens, but our biases can creep up on us without us even realizing it.

I required a week of intravenous (IV) antibiotics before I was discharged home. Multiple blood draws, sometimes scheduled an hour apart; nurse evaluations in the middle of the night; and the nurse call light for the entire floor waking me up at odd hours exposed me to a new dimension of being hospitalized. This incident opened my eyes to a power differential that exists between patients and the healthcare providers. I realized that we are very quick to point out that we are doing what is best for a patient, even if it is uncomfortable or downright scarywithout ever considering the emotional and physical turmoil a patient is going through. My experience changed me; I recognize the anger a patient feels because of multiple blood draws every day. I now understand how the constant interruption of sleep cycles because of laboratory draws and vital sign monitoring would inexplicably make an octogenarian lose all bearings of time and place when hospitalized. I find myself asking if I really need to make my patients go through an entire battery of tests, or is there something else that I can do to make their hospital course any easier. I feel the need to sit down with my patients and ask them about small things, their pain control, and their sleep patterns during the hospitalization. I have realized that these small gestures can make a significant impact in the interaction between a physician and a patient.

As physicians and medical professionals, we come with our own set of biases, but our profession further jaundices our opinions about patient needs and demands. Biases are not just based on age, sex, or socioeconomic background, but also on our perception of the severity of a disease process. Perhaps words like frequent fliers and gomers are just a manifestation of this prejudice. We are taught to be objective in our daily interactions with patients, but this also indoctrinates a degree of cynicism. Slowly, this cynicism creeps into our daily patient interactions. We forget that patients with multiple medical problems and frequent admissions also need our help. A lack of tangible diagnosis does not mean the absence of disease. As physicians, we need to evaluate our interaction with patients closely. It is the frequent fliers and the old and debilitated individuals that need the closest scrutiny. If a patient with multiple admissions for pain has come in, we need to give them the benefit of the doubt when we address their complaints. I have realized that the occasional manipulative patient will let me down, but in order to practice this profession I have to leave skepticism out of any patient interaction. I recognize that I am not going to transform patient behavior, but I can try to give them the advantage whenever I can.

Our education system values compassion and professionalism, and we try to inculcate these values in our young physicians. Our curriculums try to incorporate compassion in our daily patient interactions, but I feel that simulated patient encounters and checklists make patient contact mechanical. We develop skills to diagnose diseases through repetition, but we fail to teach our students about the individuality of a patient. In the age of quality improvement and patient safety, the ethics and basic decency of our profession has taken a back seat. My illness has forced me to consider my role as a clinician‐educator. I feel that this experience was as important as any training I received in my journey as a physician. Looking at the spectrum of disease from the other side has opened new avenues for me as a physician. I have come to realize that as educators we have the responsibility to teach our students to become empathic and considerate healers.

Feedback surveys and simulated patient encounters give us an inaccurate assessment of student interaction with patients. These controlled environments can never take the place of a real patient. Time spent at the bedside with a patient or a family is becoming scarcer because of time constraints and work hour rules. But despite these changes we can devise new ways to stimulate critical thinking. Interaction of residents with patients can be outside of their daily responsibilities. Perhaps a rotation in which the residents review charts and interact with patients in a purely nonclinical role will force them to look at people as individuals rather than just patients. A desensitization at the end of residency to make them think as human beings first and physicians second might modify their decision making. Role reversals can serve as a valuable tool to achieve this goal. Perhaps our evaluation system needs to change from a retrospective subjective scrutiny of resident performance to a more objective analysis of patient care.

I strongly feel that we need to instill these virtues in our trainees. Perhaps they will never fully grasp the vulnerability a patient feels while lying in a hospital bed, but it is neither naive nor overly optimistic to suppose that this education can have a constructive effect on their behavior.

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Issue
Journal of Hospital Medicine - 4(9)
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Page Number
574-575
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perspective, chief resident, emergency medical services (EMS)
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I lay tossing and turning in the uncomfortable bed; the strange room with cables and stands strewn everywhere was very familiar but at the same time alien to me. I lay there thinking how I ended up here. Only a few short weeks ago I was on my way to a successful career as a hospitalist. I had just finished my chief residency, confident in my skills as a clinician. I considered myself to be a strong patient advocate and felt proud of the fact that I kept the patient above everything else. But I had no inkling of what the future had in store for me. I was not supposed to be a patient, I was young and healthy; surely this had to be a mistake. I realized that I just wasn't ready to handle the situation from the other side!

My nightmare started about a week before, when I woke up with excruciating abdominal pain, too weak to even call out for help. I eventually mustered enough strength to call Emergency Medical Services (EMS), the differential diagnosis of my symptoms going through my head. Surely I had perforated an ulcer! The increased proton pump inhibitor consumption wasn't just because of the rigors of the chief residency.

At the triage station, I could see the nurse looking at me, I knew that look, Great! She thinks I am a pain medication seeker. Even though it was a rude awakening, I realized I was disheveled, unkempt, and looked like anyone else on the street. Between spasms of pain and nursing my bruised ego, I blurted out, Can I have something for this pain!? I can't take it any more. All I got back was a blank stare and a dry, We will have to wait till the doctor sees you.

The Emergency Room (ER) physician recognized me as one of the new hospitalists. The demeanor of the staff changed perceptibly; I got the pain medications and the nurses paid close attention to my overall comfort. A battery of tests was ordered and an abdominal computed tomography (CT) scan revealed acute cholecystitis. I underwent an emergent cholecystectomy. On the third postoperative day I developed a nonproductive cough. The fever started within the next 24 hours. A CT scan revealed a large left lower lobe pneumonia.

God, why is this happening to me? I was in a daze while arrangements were being made to admit me. It was a different hospital, but here the treatment from the nurses was completely different. They had known me for almost 4 years, and had followed my progress from a green, wet‐behind‐the‐ears intern, to a chief resident, and eventually to an attending physician. Over the years they had learned to trust and respect me, but more importantly they had a bond with me that had developed over the years. This familiarity affected their interaction with me in this different role. I was astonished by how different our behaviors can be, based on our perception of the patient. As medical professionals we want to think that we look at people through the same lens, but our biases can creep up on us without us even realizing it.

I required a week of intravenous (IV) antibiotics before I was discharged home. Multiple blood draws, sometimes scheduled an hour apart; nurse evaluations in the middle of the night; and the nurse call light for the entire floor waking me up at odd hours exposed me to a new dimension of being hospitalized. This incident opened my eyes to a power differential that exists between patients and the healthcare providers. I realized that we are very quick to point out that we are doing what is best for a patient, even if it is uncomfortable or downright scarywithout ever considering the emotional and physical turmoil a patient is going through. My experience changed me; I recognize the anger a patient feels because of multiple blood draws every day. I now understand how the constant interruption of sleep cycles because of laboratory draws and vital sign monitoring would inexplicably make an octogenarian lose all bearings of time and place when hospitalized. I find myself asking if I really need to make my patients go through an entire battery of tests, or is there something else that I can do to make their hospital course any easier. I feel the need to sit down with my patients and ask them about small things, their pain control, and their sleep patterns during the hospitalization. I have realized that these small gestures can make a significant impact in the interaction between a physician and a patient.

As physicians and medical professionals, we come with our own set of biases, but our profession further jaundices our opinions about patient needs and demands. Biases are not just based on age, sex, or socioeconomic background, but also on our perception of the severity of a disease process. Perhaps words like frequent fliers and gomers are just a manifestation of this prejudice. We are taught to be objective in our daily interactions with patients, but this also indoctrinates a degree of cynicism. Slowly, this cynicism creeps into our daily patient interactions. We forget that patients with multiple medical problems and frequent admissions also need our help. A lack of tangible diagnosis does not mean the absence of disease. As physicians, we need to evaluate our interaction with patients closely. It is the frequent fliers and the old and debilitated individuals that need the closest scrutiny. If a patient with multiple admissions for pain has come in, we need to give them the benefit of the doubt when we address their complaints. I have realized that the occasional manipulative patient will let me down, but in order to practice this profession I have to leave skepticism out of any patient interaction. I recognize that I am not going to transform patient behavior, but I can try to give them the advantage whenever I can.

Our education system values compassion and professionalism, and we try to inculcate these values in our young physicians. Our curriculums try to incorporate compassion in our daily patient interactions, but I feel that simulated patient encounters and checklists make patient contact mechanical. We develop skills to diagnose diseases through repetition, but we fail to teach our students about the individuality of a patient. In the age of quality improvement and patient safety, the ethics and basic decency of our profession has taken a back seat. My illness has forced me to consider my role as a clinician‐educator. I feel that this experience was as important as any training I received in my journey as a physician. Looking at the spectrum of disease from the other side has opened new avenues for me as a physician. I have come to realize that as educators we have the responsibility to teach our students to become empathic and considerate healers.

Feedback surveys and simulated patient encounters give us an inaccurate assessment of student interaction with patients. These controlled environments can never take the place of a real patient. Time spent at the bedside with a patient or a family is becoming scarcer because of time constraints and work hour rules. But despite these changes we can devise new ways to stimulate critical thinking. Interaction of residents with patients can be outside of their daily responsibilities. Perhaps a rotation in which the residents review charts and interact with patients in a purely nonclinical role will force them to look at people as individuals rather than just patients. A desensitization at the end of residency to make them think as human beings first and physicians second might modify their decision making. Role reversals can serve as a valuable tool to achieve this goal. Perhaps our evaluation system needs to change from a retrospective subjective scrutiny of resident performance to a more objective analysis of patient care.

I strongly feel that we need to instill these virtues in our trainees. Perhaps they will never fully grasp the vulnerability a patient feels while lying in a hospital bed, but it is neither naive nor overly optimistic to suppose that this education can have a constructive effect on their behavior.

I lay tossing and turning in the uncomfortable bed; the strange room with cables and stands strewn everywhere was very familiar but at the same time alien to me. I lay there thinking how I ended up here. Only a few short weeks ago I was on my way to a successful career as a hospitalist. I had just finished my chief residency, confident in my skills as a clinician. I considered myself to be a strong patient advocate and felt proud of the fact that I kept the patient above everything else. But I had no inkling of what the future had in store for me. I was not supposed to be a patient, I was young and healthy; surely this had to be a mistake. I realized that I just wasn't ready to handle the situation from the other side!

My nightmare started about a week before, when I woke up with excruciating abdominal pain, too weak to even call out for help. I eventually mustered enough strength to call Emergency Medical Services (EMS), the differential diagnosis of my symptoms going through my head. Surely I had perforated an ulcer! The increased proton pump inhibitor consumption wasn't just because of the rigors of the chief residency.

At the triage station, I could see the nurse looking at me, I knew that look, Great! She thinks I am a pain medication seeker. Even though it was a rude awakening, I realized I was disheveled, unkempt, and looked like anyone else on the street. Between spasms of pain and nursing my bruised ego, I blurted out, Can I have something for this pain!? I can't take it any more. All I got back was a blank stare and a dry, We will have to wait till the doctor sees you.

The Emergency Room (ER) physician recognized me as one of the new hospitalists. The demeanor of the staff changed perceptibly; I got the pain medications and the nurses paid close attention to my overall comfort. A battery of tests was ordered and an abdominal computed tomography (CT) scan revealed acute cholecystitis. I underwent an emergent cholecystectomy. On the third postoperative day I developed a nonproductive cough. The fever started within the next 24 hours. A CT scan revealed a large left lower lobe pneumonia.

God, why is this happening to me? I was in a daze while arrangements were being made to admit me. It was a different hospital, but here the treatment from the nurses was completely different. They had known me for almost 4 years, and had followed my progress from a green, wet‐behind‐the‐ears intern, to a chief resident, and eventually to an attending physician. Over the years they had learned to trust and respect me, but more importantly they had a bond with me that had developed over the years. This familiarity affected their interaction with me in this different role. I was astonished by how different our behaviors can be, based on our perception of the patient. As medical professionals we want to think that we look at people through the same lens, but our biases can creep up on us without us even realizing it.

I required a week of intravenous (IV) antibiotics before I was discharged home. Multiple blood draws, sometimes scheduled an hour apart; nurse evaluations in the middle of the night; and the nurse call light for the entire floor waking me up at odd hours exposed me to a new dimension of being hospitalized. This incident opened my eyes to a power differential that exists between patients and the healthcare providers. I realized that we are very quick to point out that we are doing what is best for a patient, even if it is uncomfortable or downright scarywithout ever considering the emotional and physical turmoil a patient is going through. My experience changed me; I recognize the anger a patient feels because of multiple blood draws every day. I now understand how the constant interruption of sleep cycles because of laboratory draws and vital sign monitoring would inexplicably make an octogenarian lose all bearings of time and place when hospitalized. I find myself asking if I really need to make my patients go through an entire battery of tests, or is there something else that I can do to make their hospital course any easier. I feel the need to sit down with my patients and ask them about small things, their pain control, and their sleep patterns during the hospitalization. I have realized that these small gestures can make a significant impact in the interaction between a physician and a patient.

As physicians and medical professionals, we come with our own set of biases, but our profession further jaundices our opinions about patient needs and demands. Biases are not just based on age, sex, or socioeconomic background, but also on our perception of the severity of a disease process. Perhaps words like frequent fliers and gomers are just a manifestation of this prejudice. We are taught to be objective in our daily interactions with patients, but this also indoctrinates a degree of cynicism. Slowly, this cynicism creeps into our daily patient interactions. We forget that patients with multiple medical problems and frequent admissions also need our help. A lack of tangible diagnosis does not mean the absence of disease. As physicians, we need to evaluate our interaction with patients closely. It is the frequent fliers and the old and debilitated individuals that need the closest scrutiny. If a patient with multiple admissions for pain has come in, we need to give them the benefit of the doubt when we address their complaints. I have realized that the occasional manipulative patient will let me down, but in order to practice this profession I have to leave skepticism out of any patient interaction. I recognize that I am not going to transform patient behavior, but I can try to give them the advantage whenever I can.

Our education system values compassion and professionalism, and we try to inculcate these values in our young physicians. Our curriculums try to incorporate compassion in our daily patient interactions, but I feel that simulated patient encounters and checklists make patient contact mechanical. We develop skills to diagnose diseases through repetition, but we fail to teach our students about the individuality of a patient. In the age of quality improvement and patient safety, the ethics and basic decency of our profession has taken a back seat. My illness has forced me to consider my role as a clinician‐educator. I feel that this experience was as important as any training I received in my journey as a physician. Looking at the spectrum of disease from the other side has opened new avenues for me as a physician. I have come to realize that as educators we have the responsibility to teach our students to become empathic and considerate healers.

Feedback surveys and simulated patient encounters give us an inaccurate assessment of student interaction with patients. These controlled environments can never take the place of a real patient. Time spent at the bedside with a patient or a family is becoming scarcer because of time constraints and work hour rules. But despite these changes we can devise new ways to stimulate critical thinking. Interaction of residents with patients can be outside of their daily responsibilities. Perhaps a rotation in which the residents review charts and interact with patients in a purely nonclinical role will force them to look at people as individuals rather than just patients. A desensitization at the end of residency to make them think as human beings first and physicians second might modify their decision making. Role reversals can serve as a valuable tool to achieve this goal. Perhaps our evaluation system needs to change from a retrospective subjective scrutiny of resident performance to a more objective analysis of patient care.

I strongly feel that we need to instill these virtues in our trainees. Perhaps they will never fully grasp the vulnerability a patient feels while lying in a hospital bed, but it is neither naive nor overly optimistic to suppose that this education can have a constructive effect on their behavior.

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Treating the renal patient who has a fracture: Opinion vs evidence

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Treating the renal patient who has a fracture: Opinion vs evidence

Managing bone health in patients with chronic kidney disease presents unique challenges. While the common end point—a fracture—is comparable to that in patients with osteoporosis, the underlying metabolic conditions differ from patient to patient with chronic kidney disease and may be dramatically different from those in patients who have osteoporosis without chronic kidney disease.

See related article

Renal osteodystrophy is not osteoporosis

Renal osteodystrophy is not osteoporosis. While osteoporosis in people without kidney disease is defined clinically on the basis of bone mineral density (measured by bone densitometry), renal osteodystrophy is a histologic diagnosis made on bone biopsy: it is a continuum between frankly low-turnoverbone disease—encompassing adynamic bone disease and osteomalacia—and frankly highturnover-bone disease, with severe secondary hyperparathyroid bone disease and osteitis fibrosa. Histologically, there may or may not be low trabecular bone volume or loss of connectivity typical of the bone loss in osteoporosis.

Patients at both ends of the spectrum of bone turnover in renal osteodystrophy may have the same bone mineral density on densitometry. Low bone mineral density may reflect inadequate mineralization (seen in osteomalacia and adynamic bone disease) or increased peritrabecular fibrosis (seen in secondary hyperparathyroid bone disease). High bone mineral density readings may capture extraosseous calcifications, which are very common in chronic kidney disease.

Renal osteodystrophy is part of the syndrome called chronic kidney disease-mineral and bone disease,1 which is not limited to bone fractures but may also affect vascular health. Abnormal calcium deposits in vascular tissue—consistent with calciphylaxis and associated with increased morbidity and mortality rates in chronic kidney disease—may occur with low bone turnover.

The diagnosis of osteoporosis in the general population is based on clinical evidence: the measured bone mineral density is compared with normalized scores. Histologically, the bone of the osteoporotic patient shows osteopenia with increased bone turnover and a shift toward increased bone resorption, resulting in loss of connectivity of the trabeculae, as well as decreased trabecular volume. These conditions are common in advanced age and in certain pathologic states (eg, steroid therapy, metastatic bone disease, Paget disease of bone).

It is well accepted that the risk of fracture in osteoporosis increases as measured bone mineral density decreases. Conversely, increasing bone mineral density has been correlated with fewer fractures. The clinician is often guided by biomarkers of bone metabolism such as urinary N-terminal cross-linked telopeptides of collagen (NTx) in diagnosing and treating bone breakdown.

Can bisphosphonates be used in chronic kidney disease?

Bisphosphonates are antiresorptive agents that bind to the hydroxyapatite of bone. They poison the osteoclast (the bone-resorbing cell), causing its death and thereby halting the resorption of bone. Osteoblasts—the boneforming cells—are presumably not affected, and the bone continues to make osteoid, which is subsequently mineralized. Bone turnover is dramatically decreased. The net effect is increased bone density in people with osteoporosis. The half-life of these agents is years.

In the general population, bisphosphonate therapy has been associated with decreased risk of fragility bone fractures. However, the long-term effects are not yet known. Indeed, jaw necrosis—possibly due to low bone turnover—is being reported with increasing frequency.2 Fractures associated with low bone turnover in patients without chronic kidney disease treated with bisphosphonates longterm are now being reported.3,4

In an article in this issue of the Journal,5 the author advocates the use of bisphosphonate therapy in patients with chronic kidney disease who have low bone mineral density. However, treating patients who have chronic kidney disease on the basis of low bone mineral density with bone-suppressing agents may further depress bone turnover and lead to more extraosseous calcifications as the turnedoff bone is unable to accept serum calcium.6

Further, it is unclear how long “long-term” would be in a patient with advanced chronic kidney disease: Would the half-life of the bisphosphonates be tremendously increased, leading to adverse events sooner? Would adynamic bone disease promptly develop, leading to rampant jaw necrosis and bone fractures? Would vascular calcification flourish?

 

 

Bone biomarkers are hard to interpret in chronic kidney disease

In chronic kidney disease, the interpretation of biomarkers of bone metabolism is notoriously unreliable. The usual chemistry values associated with clinical osteoporosis in the general population—ie, elevated levels of urinary NTx, serum C-terminal cross-linked telopeptides of collagen (CTx), osteocalcin, and bone-specific alkaline phosphatase—are not valid in patients with chronic kidney disease, for obvious reasons: with declining renal function, the various markers accumulate in the serum. Urinary NTx does not apply in patients with advanced chronic kidney disease or end-stage renal disease.

How should renal osteodystrophy be treated?

Nephrologists currently focus therapy on reducing hyperphosphatemia (associated with increased morbidity across all stages of chronic kidney disease), replenishing vitamin D as much as possible without causing hyperphosphatemia and hypercalcemia, and suppressing parathyroid hormone secretion.

However, there is not enough evidence on what the goal should be with respect to parathyroid hormone in patients with chronic kidney disease who are not on dialysis. Although in the recent past many believed that parathyroid hormone goals should be 150 to 300 pg/mL in dialysis patients, the latest guidelines suggest that perhaps this goal is too narrow and may lead to more adynamic bone disease. Similarly, there is no consensus on the use of synthetic parathyroid hormone analogues.

Bisphosphonate therapy, particularly with pamidronate (Aredia) and zolendronic acid (Reclast), has been associated with adverse renal effects even in patients without chronic kidney disease. There are no prospective studies of the effects of these agents in patients with depressed renal function.

The patient with chronic kidney disease who has a fracture remains a unique problem for the nephrologist, primary care physician, and subspecialist. Efforts should be concentrated on preventing and treating metabolic bone disease in its entire spectrum, with rational, prospective studies, and should not depend on anecdotal reports. Opinions abound, without adequate evidence to back them up.

References
  1. Moe S, Drüeke T, Cunningham J, et al; Kidney Disease: Improving Global Outcomes (KDIGO). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69:19451953.
  2. Rustemeyer J, Bremerich A. Bisphosphonate-associated osteonecrosis of the jaw: what do we currently know? A survey of knowledge given in the recent literature. Clin Oral Investig 2009; Epub ahead of print.
  3. Armamento-Villareal R, Napoli N, Diemer K, et al. Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series. Calcif Tissue Int 2009; 85:3744.
  4. Ali T, Jay RH. Spontaneous femoral shaft fracture after long-term alendronate. Age Ageing 2009; Epub ahead of print.
  5. Miller PD. Fragility fractures in chronic kidney disease: an opinionbased approach. Cleve Clin J Med 2009; 76:713721.
  6. Toussaint ND, Elder GJ, Kerr PG. Bisphosphonates in chronic kidney disease; balancing potential benefits and adverse effects on bone and soft tissue. Clin J Am Soc Nephrol 2009; 4:221233.
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Address: Maria Coco, MD, MS, Renal Division, Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467; e-mail [email protected]

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Address: Maria Coco, MD, MS, Renal Division, Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467; e-mail [email protected]

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Managing bone health in patients with chronic kidney disease presents unique challenges. While the common end point—a fracture—is comparable to that in patients with osteoporosis, the underlying metabolic conditions differ from patient to patient with chronic kidney disease and may be dramatically different from those in patients who have osteoporosis without chronic kidney disease.

See related article

Renal osteodystrophy is not osteoporosis

Renal osteodystrophy is not osteoporosis. While osteoporosis in people without kidney disease is defined clinically on the basis of bone mineral density (measured by bone densitometry), renal osteodystrophy is a histologic diagnosis made on bone biopsy: it is a continuum between frankly low-turnoverbone disease—encompassing adynamic bone disease and osteomalacia—and frankly highturnover-bone disease, with severe secondary hyperparathyroid bone disease and osteitis fibrosa. Histologically, there may or may not be low trabecular bone volume or loss of connectivity typical of the bone loss in osteoporosis.

Patients at both ends of the spectrum of bone turnover in renal osteodystrophy may have the same bone mineral density on densitometry. Low bone mineral density may reflect inadequate mineralization (seen in osteomalacia and adynamic bone disease) or increased peritrabecular fibrosis (seen in secondary hyperparathyroid bone disease). High bone mineral density readings may capture extraosseous calcifications, which are very common in chronic kidney disease.

Renal osteodystrophy is part of the syndrome called chronic kidney disease-mineral and bone disease,1 which is not limited to bone fractures but may also affect vascular health. Abnormal calcium deposits in vascular tissue—consistent with calciphylaxis and associated with increased morbidity and mortality rates in chronic kidney disease—may occur with low bone turnover.

The diagnosis of osteoporosis in the general population is based on clinical evidence: the measured bone mineral density is compared with normalized scores. Histologically, the bone of the osteoporotic patient shows osteopenia with increased bone turnover and a shift toward increased bone resorption, resulting in loss of connectivity of the trabeculae, as well as decreased trabecular volume. These conditions are common in advanced age and in certain pathologic states (eg, steroid therapy, metastatic bone disease, Paget disease of bone).

It is well accepted that the risk of fracture in osteoporosis increases as measured bone mineral density decreases. Conversely, increasing bone mineral density has been correlated with fewer fractures. The clinician is often guided by biomarkers of bone metabolism such as urinary N-terminal cross-linked telopeptides of collagen (NTx) in diagnosing and treating bone breakdown.

Can bisphosphonates be used in chronic kidney disease?

Bisphosphonates are antiresorptive agents that bind to the hydroxyapatite of bone. They poison the osteoclast (the bone-resorbing cell), causing its death and thereby halting the resorption of bone. Osteoblasts—the boneforming cells—are presumably not affected, and the bone continues to make osteoid, which is subsequently mineralized. Bone turnover is dramatically decreased. The net effect is increased bone density in people with osteoporosis. The half-life of these agents is years.

In the general population, bisphosphonate therapy has been associated with decreased risk of fragility bone fractures. However, the long-term effects are not yet known. Indeed, jaw necrosis—possibly due to low bone turnover—is being reported with increasing frequency.2 Fractures associated with low bone turnover in patients without chronic kidney disease treated with bisphosphonates longterm are now being reported.3,4

In an article in this issue of the Journal,5 the author advocates the use of bisphosphonate therapy in patients with chronic kidney disease who have low bone mineral density. However, treating patients who have chronic kidney disease on the basis of low bone mineral density with bone-suppressing agents may further depress bone turnover and lead to more extraosseous calcifications as the turnedoff bone is unable to accept serum calcium.6

Further, it is unclear how long “long-term” would be in a patient with advanced chronic kidney disease: Would the half-life of the bisphosphonates be tremendously increased, leading to adverse events sooner? Would adynamic bone disease promptly develop, leading to rampant jaw necrosis and bone fractures? Would vascular calcification flourish?

 

 

Bone biomarkers are hard to interpret in chronic kidney disease

In chronic kidney disease, the interpretation of biomarkers of bone metabolism is notoriously unreliable. The usual chemistry values associated with clinical osteoporosis in the general population—ie, elevated levels of urinary NTx, serum C-terminal cross-linked telopeptides of collagen (CTx), osteocalcin, and bone-specific alkaline phosphatase—are not valid in patients with chronic kidney disease, for obvious reasons: with declining renal function, the various markers accumulate in the serum. Urinary NTx does not apply in patients with advanced chronic kidney disease or end-stage renal disease.

How should renal osteodystrophy be treated?

Nephrologists currently focus therapy on reducing hyperphosphatemia (associated with increased morbidity across all stages of chronic kidney disease), replenishing vitamin D as much as possible without causing hyperphosphatemia and hypercalcemia, and suppressing parathyroid hormone secretion.

However, there is not enough evidence on what the goal should be with respect to parathyroid hormone in patients with chronic kidney disease who are not on dialysis. Although in the recent past many believed that parathyroid hormone goals should be 150 to 300 pg/mL in dialysis patients, the latest guidelines suggest that perhaps this goal is too narrow and may lead to more adynamic bone disease. Similarly, there is no consensus on the use of synthetic parathyroid hormone analogues.

Bisphosphonate therapy, particularly with pamidronate (Aredia) and zolendronic acid (Reclast), has been associated with adverse renal effects even in patients without chronic kidney disease. There are no prospective studies of the effects of these agents in patients with depressed renal function.

The patient with chronic kidney disease who has a fracture remains a unique problem for the nephrologist, primary care physician, and subspecialist. Efforts should be concentrated on preventing and treating metabolic bone disease in its entire spectrum, with rational, prospective studies, and should not depend on anecdotal reports. Opinions abound, without adequate evidence to back them up.

Managing bone health in patients with chronic kidney disease presents unique challenges. While the common end point—a fracture—is comparable to that in patients with osteoporosis, the underlying metabolic conditions differ from patient to patient with chronic kidney disease and may be dramatically different from those in patients who have osteoporosis without chronic kidney disease.

See related article

Renal osteodystrophy is not osteoporosis

Renal osteodystrophy is not osteoporosis. While osteoporosis in people without kidney disease is defined clinically on the basis of bone mineral density (measured by bone densitometry), renal osteodystrophy is a histologic diagnosis made on bone biopsy: it is a continuum between frankly low-turnoverbone disease—encompassing adynamic bone disease and osteomalacia—and frankly highturnover-bone disease, with severe secondary hyperparathyroid bone disease and osteitis fibrosa. Histologically, there may or may not be low trabecular bone volume or loss of connectivity typical of the bone loss in osteoporosis.

Patients at both ends of the spectrum of bone turnover in renal osteodystrophy may have the same bone mineral density on densitometry. Low bone mineral density may reflect inadequate mineralization (seen in osteomalacia and adynamic bone disease) or increased peritrabecular fibrosis (seen in secondary hyperparathyroid bone disease). High bone mineral density readings may capture extraosseous calcifications, which are very common in chronic kidney disease.

Renal osteodystrophy is part of the syndrome called chronic kidney disease-mineral and bone disease,1 which is not limited to bone fractures but may also affect vascular health. Abnormal calcium deposits in vascular tissue—consistent with calciphylaxis and associated with increased morbidity and mortality rates in chronic kidney disease—may occur with low bone turnover.

The diagnosis of osteoporosis in the general population is based on clinical evidence: the measured bone mineral density is compared with normalized scores. Histologically, the bone of the osteoporotic patient shows osteopenia with increased bone turnover and a shift toward increased bone resorption, resulting in loss of connectivity of the trabeculae, as well as decreased trabecular volume. These conditions are common in advanced age and in certain pathologic states (eg, steroid therapy, metastatic bone disease, Paget disease of bone).

It is well accepted that the risk of fracture in osteoporosis increases as measured bone mineral density decreases. Conversely, increasing bone mineral density has been correlated with fewer fractures. The clinician is often guided by biomarkers of bone metabolism such as urinary N-terminal cross-linked telopeptides of collagen (NTx) in diagnosing and treating bone breakdown.

Can bisphosphonates be used in chronic kidney disease?

Bisphosphonates are antiresorptive agents that bind to the hydroxyapatite of bone. They poison the osteoclast (the bone-resorbing cell), causing its death and thereby halting the resorption of bone. Osteoblasts—the boneforming cells—are presumably not affected, and the bone continues to make osteoid, which is subsequently mineralized. Bone turnover is dramatically decreased. The net effect is increased bone density in people with osteoporosis. The half-life of these agents is years.

In the general population, bisphosphonate therapy has been associated with decreased risk of fragility bone fractures. However, the long-term effects are not yet known. Indeed, jaw necrosis—possibly due to low bone turnover—is being reported with increasing frequency.2 Fractures associated with low bone turnover in patients without chronic kidney disease treated with bisphosphonates longterm are now being reported.3,4

In an article in this issue of the Journal,5 the author advocates the use of bisphosphonate therapy in patients with chronic kidney disease who have low bone mineral density. However, treating patients who have chronic kidney disease on the basis of low bone mineral density with bone-suppressing agents may further depress bone turnover and lead to more extraosseous calcifications as the turnedoff bone is unable to accept serum calcium.6

Further, it is unclear how long “long-term” would be in a patient with advanced chronic kidney disease: Would the half-life of the bisphosphonates be tremendously increased, leading to adverse events sooner? Would adynamic bone disease promptly develop, leading to rampant jaw necrosis and bone fractures? Would vascular calcification flourish?

 

 

Bone biomarkers are hard to interpret in chronic kidney disease

In chronic kidney disease, the interpretation of biomarkers of bone metabolism is notoriously unreliable. The usual chemistry values associated with clinical osteoporosis in the general population—ie, elevated levels of urinary NTx, serum C-terminal cross-linked telopeptides of collagen (CTx), osteocalcin, and bone-specific alkaline phosphatase—are not valid in patients with chronic kidney disease, for obvious reasons: with declining renal function, the various markers accumulate in the serum. Urinary NTx does not apply in patients with advanced chronic kidney disease or end-stage renal disease.

How should renal osteodystrophy be treated?

Nephrologists currently focus therapy on reducing hyperphosphatemia (associated with increased morbidity across all stages of chronic kidney disease), replenishing vitamin D as much as possible without causing hyperphosphatemia and hypercalcemia, and suppressing parathyroid hormone secretion.

However, there is not enough evidence on what the goal should be with respect to parathyroid hormone in patients with chronic kidney disease who are not on dialysis. Although in the recent past many believed that parathyroid hormone goals should be 150 to 300 pg/mL in dialysis patients, the latest guidelines suggest that perhaps this goal is too narrow and may lead to more adynamic bone disease. Similarly, there is no consensus on the use of synthetic parathyroid hormone analogues.

Bisphosphonate therapy, particularly with pamidronate (Aredia) and zolendronic acid (Reclast), has been associated with adverse renal effects even in patients without chronic kidney disease. There are no prospective studies of the effects of these agents in patients with depressed renal function.

The patient with chronic kidney disease who has a fracture remains a unique problem for the nephrologist, primary care physician, and subspecialist. Efforts should be concentrated on preventing and treating metabolic bone disease in its entire spectrum, with rational, prospective studies, and should not depend on anecdotal reports. Opinions abound, without adequate evidence to back them up.

References
  1. Moe S, Drüeke T, Cunningham J, et al; Kidney Disease: Improving Global Outcomes (KDIGO). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69:19451953.
  2. Rustemeyer J, Bremerich A. Bisphosphonate-associated osteonecrosis of the jaw: what do we currently know? A survey of knowledge given in the recent literature. Clin Oral Investig 2009; Epub ahead of print.
  3. Armamento-Villareal R, Napoli N, Diemer K, et al. Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series. Calcif Tissue Int 2009; 85:3744.
  4. Ali T, Jay RH. Spontaneous femoral shaft fracture after long-term alendronate. Age Ageing 2009; Epub ahead of print.
  5. Miller PD. Fragility fractures in chronic kidney disease: an opinionbased approach. Cleve Clin J Med 2009; 76:713721.
  6. Toussaint ND, Elder GJ, Kerr PG. Bisphosphonates in chronic kidney disease; balancing potential benefits and adverse effects on bone and soft tissue. Clin J Am Soc Nephrol 2009; 4:221233.
References
  1. Moe S, Drüeke T, Cunningham J, et al; Kidney Disease: Improving Global Outcomes (KDIGO). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69:19451953.
  2. Rustemeyer J, Bremerich A. Bisphosphonate-associated osteonecrosis of the jaw: what do we currently know? A survey of knowledge given in the recent literature. Clin Oral Investig 2009; Epub ahead of print.
  3. Armamento-Villareal R, Napoli N, Diemer K, et al. Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series. Calcif Tissue Int 2009; 85:3744.
  4. Ali T, Jay RH. Spontaneous femoral shaft fracture after long-term alendronate. Age Ageing 2009; Epub ahead of print.
  5. Miller PD. Fragility fractures in chronic kidney disease: an opinionbased approach. Cleve Clin J Med 2009; 76:713721.
  6. Toussaint ND, Elder GJ, Kerr PG. Bisphosphonates in chronic kidney disease; balancing potential benefits and adverse effects on bone and soft tissue. Clin J Am Soc Nephrol 2009; 4:221233.
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Hospitalists Best Educators in the Hospital

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Hospitalists are increasingly assuming a primary role in medical education in the hospital setting, as they also steadily care for a larger portion of hospitalized patients.1 This issue of the Journal of Hospital Medicine highlights the role of hospitalists as teachers in academic medical centers, confirming their expanding and positive role in resident and medical student education. A survey of academic medical centers, a systematic review, an evaluation of the implementation of an educational curriculum, and a survey of residents hint at the challenges hospitalists face in teaching, but also expose us to a more advanced yet facile approach to evaluating the effectiveness of a teaching intervention.25 These publications provoke interesting questions about clinical teaching that hospital medicine educators and researchers should pursue answering. I believe they will also encourage us to innovate in medical education and assessment of that teaching.

Traditionally, teaching attendings for resident teams on medicine or pediatric services rotated through these duties for 1 to 3 months each year, while spending the majority of their time in clinic or research activities. The increasing complexity of hospitalized patients and the pressure to reduce length of stay prompted closer oversight of trainees. With the advent of resident work‐hour restrictions, the need for greater clinical involvement by attending physicians made it increasingly difficult to maintain the traditional model of limited engagement by faculty attendings. Simply put, the dwindling pool of willing and able teaching attendings encouraged teaching hospitals to employ hospitalists to fill the gap in teaching and supervision, as well as clinical coverage.6

Beasley et al.2 report that resident work‐hour restrictions were associated with an increase in the number of teaching hospitals employing hospitalists to 79% of 193 surveyed hospitals in 2007. Of those hospitals with hospitalists, 92% reported that hospitalists serve as attendings on the teaching service. Hospitalists also teach in a number of other venues within these programs, including formal teaching rounds without direct care responsibility, along with delivering didactic lectures and clinical skills education.

How well are teaching hospitalists performing compared to traditional teaching attendings? Natarajan et al.4 provide an important summary of the evidence in a systematic review of studies comparing teaching efforts of hospitalist attendings to those of nonhospitalist attendings. Eight studies from a variety of institutions measured trainee (resident or medical student) attitudes. It is gratifying to learn that hospitalists were generally rated higher at overall teaching effectiveness, provision of feedback, knowledge base, and involvement of the learner in patient care. It seems likely that publication bias would overestimate the positive effect of hospitalists on learner attitudes. However, there are plausible reasons that the positive effect is accurate. Because their professional responsibilities are focused in the hospital, hospitalists should naturally be more available to learners for teaching and feedback. Hospitalists tend to be younger in their academic careers, placing them closer to the cutting edge of knowledge gained during residency and possibly fellowship. They may be more in tune with the needs and pressures faced by their learners, having dealt with these same challenges either during recent training or during nonteaching rotations.

As a relatively young specialty with young and developing academic hospitalists, will the advantage suggested by the Natarajan et al.4 systematic review be sustained over the long term as careers in hospital medicine mature? A 2005 systematic review studying this question among practicing clinicians found, somewhat paradoxically, that older, more experienced clinicians appeared to be at risk for providing lower‐quality care.7 To avoid this decline in clinical effectiveness, hospitalists should proactively seek innovative ways to refresh and update their knowledge and skills throughout their careers. This is particularly critical for teaching physicians. We should seize the opportunity to study the relationship between advancing clinical/teaching experience and educational quality within our teaching programs.

The review by Natarajan et al.4 should also challenge the hospitalist community to achieve even higher levels of proficiency as teachers of medicine. The review alludes to bedside teaching and attention to psychosocial aspects of care as opportunities for improvement by hospitalist teachers. A recent study suggested that physical examination instruction receives declining attention from inpatient teachers and that there are opportunities to increase the amount of bedside teaching.8 A provocative study of inpatients admitted to a teaching service found that physical examination could substantially impact patient care, but that trainees often failed to appreciate significant findings on initial examination.9 How do teaching hospitalists become proficient at physical examination and bedside teaching? Are there models around the country that are successfully developing outstanding clinician educators, incorporating teach‐the‐teacher models to improve physical examination and bedside teaching?

A practical limitation of attitude surveys and learner evaluation is the well‐known phenomenon of grade inflation that resulted in high ratings for all attending groups in the studies summarized by Natarajan et al.4 This limits the ability of surveys or evaluations to distinguish truly outstanding teachers and consequently makes it difficult to analyze the attributes of these teachers. We need better tools to detect and learn teaching techniques from great teachers in the clinical environment. We need studies evaluating the effect of teaching hospitalists on learner knowledge or, even more importantly, learner outcomes. Ultimately, we need studies of educational interventions that evaluate the impact of these interventions on patient outcome.

Wright et al.5 provide guidance as they describe the evaluation of a teaching intervention that moves beyond measurement of knowledge or attitudes. The Johns Hopkins Bayview hospitalist group sought to improve the quality of medical consultations performed by hospitalists and by residents rotating on the consultation service using a case‐based teaching module with audits of recent notes. The participants then audited their most recent consultation notes with feedback from the module teacher. The study employed pretests and posttests of knowledgea standard evaluation for educational interventions. This tells us little about the true impact of the teaching module. However, the study then assessed the quality of written consultations done by hospitalists before and after the educational interventions. Scores of consult notes improved significantly after the intervention, although the number of assessments for each physician was limited. Importantly, we need to know if interventions such as this are sustained over time. Wright's well‐established medical education research group's study design assessed the impact of an intervention on physician performance and moves us closer to assessment of the impact on actual patient outcomes. As clinical teachers, we would like to believe that our teaching and our educational innovations are having a positive impact on patient care. Can we demonstrate this?

As academic medical centers contend with further resident work‐hour restrictions proposed by the Institute of Medicine (IOM),10 how will this affect hospitalist teachers? The study by Mazotti et al.3 from the University of California at San Francisco residency program found that about one‐quarter of residents reported spending less time teaching after implementation of the Accreditation Council for Graduate Medical Education (ACGME) duty‐hour restrictions in 2003. Interestingly, those residents reporting less time spent teaching also reported less emotional exhaustion and perceived that they were delivering higher‐quality patient care. This raises a fascinating question for academic hospitalists. Would these findings be similar among teaching hospitalists and nonteaching hospitalists? What about hospitalists who rotate through months of teaching and nonteaching services? Is teaching emotionally exhausting for experienced teachers? A Mayo Clinic study suggested that the extent that faculty physicians are able to engage in work that is most meaningful to them as individuals is a strong determinant of faculty burnout.11 Is the hospitalist who finds teaching most rewarding at risk of burnout if they are assigned only 2 weeks a year as a teaching attending? The answers to these questions will be critical to hospitalist program leaders trying to assure sustainable careers for hospitalists in their programs.

Although the study by Mazotti et al.3 did not assess the impact of the reduction in resident teaching time on the teaching responsibilities for academic hospitalists, previous studies suggest that faculty are also teaching less since the introduction of work‐hour restrictions.12, 13 If the new IOM recommendations are enacted, who will teach? Although the reported experience following the 2003 work‐hour restrictions begs pessimism, the anticipated changes represent an opportunity for creative hospitalist teachers to demonstrate effective adaptations to the changing and compressed inpatient teaching environment.

In summary, this issue of the Journal presents studies that praise the role hospitalists play in teaching the next generation of physicians, but also gives a glimpse of future challenges and opportunities. We should take advantage of hospitalists' central position in clinical education in the hospital to innovate, study the effect on both learner outcomes and patient outcomes, and share our experiences with the hospitalist and medical education communities.

References
  1. Kuo YF, Sharma G, Freeman JL, Goodwin JS.Growth in the care of older patients by hospitalists in the United States.N Engl J Med.2009;360(11):11021112.
  2. Beasley B, McBride J, McDonald F.Hospitalists involvement in internal medicine residencies.J Hosp Med.2009;4(8):471475.
  3. Mazotti LA, Vidyarthi AR, Wachter RM, Auerbach AD, Katz PP.Impact of duty hour restriction on resident inpatient teaching.J Hosp Med.2009;4(8):476480.
  4. Natarajan P, Ranji SR, Auerbach AD, Hauer KE.Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.J Hosp Med.2009;4(8):490498.
  5. Wright R, Howell E, Landis R, Wright S, Kisuule F, Jordan M.A case‐based teaching module combined with audit and feedback to improve the quality of consultations.J Hosp Med.2009;4(8):486489.
  6. Sehgal NL, Shah HM, Parekh VI, Roy CL, Williams MV.Non‐housestaff medicine services in academic centers: models and challenges.J Hosp Med.2008;3(3):247255.
  7. Choudhry NK, Fletcher RH, Soumerai SB.Systematic review: the relationship between clinical experience and quality of health care.Ann Intern Med.2005;142(4):260273.
  8. Crumlish CM, Yialamas MA, McMahon GT.Quantification of bedside teaching by an academic hospitalist group.J Hosp Med.2009;4(5):304307.
  9. Reilly BM.Physical examination in the care of medical inpatients: an observational study.Lancet.2003;362(9390):11001105.
  10. Institute of Medicine. Resident Duty Hours: Enhancing Sleep, Supervision, and Safety. 2008. Available at: http://www.iom.edu/CMS/3809/48553/60449.aspx. Accessed September2009.
  11. Shanafelt TD, West CP, Sloan JA, et al.Career fit and burnout among academic faculty.Arch Intern Med.2009;169(10):990995.
  12. Harrison R, Allen E.Teaching internal medicine residents in the new era. Inpatient attending with duty‐hour regulations.J Gen Intern Med.2006;21(5):447452.
  13. Goitein L, Shanafelt TD, Nathens AB, Curtis JR.Effects of resident work hour limitations on faculty professional lives.J Gen Intern Med.2008;23(7):10771083.
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Hospitalists are increasingly assuming a primary role in medical education in the hospital setting, as they also steadily care for a larger portion of hospitalized patients.1 This issue of the Journal of Hospital Medicine highlights the role of hospitalists as teachers in academic medical centers, confirming their expanding and positive role in resident and medical student education. A survey of academic medical centers, a systematic review, an evaluation of the implementation of an educational curriculum, and a survey of residents hint at the challenges hospitalists face in teaching, but also expose us to a more advanced yet facile approach to evaluating the effectiveness of a teaching intervention.25 These publications provoke interesting questions about clinical teaching that hospital medicine educators and researchers should pursue answering. I believe they will also encourage us to innovate in medical education and assessment of that teaching.

Traditionally, teaching attendings for resident teams on medicine or pediatric services rotated through these duties for 1 to 3 months each year, while spending the majority of their time in clinic or research activities. The increasing complexity of hospitalized patients and the pressure to reduce length of stay prompted closer oversight of trainees. With the advent of resident work‐hour restrictions, the need for greater clinical involvement by attending physicians made it increasingly difficult to maintain the traditional model of limited engagement by faculty attendings. Simply put, the dwindling pool of willing and able teaching attendings encouraged teaching hospitals to employ hospitalists to fill the gap in teaching and supervision, as well as clinical coverage.6

Beasley et al.2 report that resident work‐hour restrictions were associated with an increase in the number of teaching hospitals employing hospitalists to 79% of 193 surveyed hospitals in 2007. Of those hospitals with hospitalists, 92% reported that hospitalists serve as attendings on the teaching service. Hospitalists also teach in a number of other venues within these programs, including formal teaching rounds without direct care responsibility, along with delivering didactic lectures and clinical skills education.

How well are teaching hospitalists performing compared to traditional teaching attendings? Natarajan et al.4 provide an important summary of the evidence in a systematic review of studies comparing teaching efforts of hospitalist attendings to those of nonhospitalist attendings. Eight studies from a variety of institutions measured trainee (resident or medical student) attitudes. It is gratifying to learn that hospitalists were generally rated higher at overall teaching effectiveness, provision of feedback, knowledge base, and involvement of the learner in patient care. It seems likely that publication bias would overestimate the positive effect of hospitalists on learner attitudes. However, there are plausible reasons that the positive effect is accurate. Because their professional responsibilities are focused in the hospital, hospitalists should naturally be more available to learners for teaching and feedback. Hospitalists tend to be younger in their academic careers, placing them closer to the cutting edge of knowledge gained during residency and possibly fellowship. They may be more in tune with the needs and pressures faced by their learners, having dealt with these same challenges either during recent training or during nonteaching rotations.

As a relatively young specialty with young and developing academic hospitalists, will the advantage suggested by the Natarajan et al.4 systematic review be sustained over the long term as careers in hospital medicine mature? A 2005 systematic review studying this question among practicing clinicians found, somewhat paradoxically, that older, more experienced clinicians appeared to be at risk for providing lower‐quality care.7 To avoid this decline in clinical effectiveness, hospitalists should proactively seek innovative ways to refresh and update their knowledge and skills throughout their careers. This is particularly critical for teaching physicians. We should seize the opportunity to study the relationship between advancing clinical/teaching experience and educational quality within our teaching programs.

The review by Natarajan et al.4 should also challenge the hospitalist community to achieve even higher levels of proficiency as teachers of medicine. The review alludes to bedside teaching and attention to psychosocial aspects of care as opportunities for improvement by hospitalist teachers. A recent study suggested that physical examination instruction receives declining attention from inpatient teachers and that there are opportunities to increase the amount of bedside teaching.8 A provocative study of inpatients admitted to a teaching service found that physical examination could substantially impact patient care, but that trainees often failed to appreciate significant findings on initial examination.9 How do teaching hospitalists become proficient at physical examination and bedside teaching? Are there models around the country that are successfully developing outstanding clinician educators, incorporating teach‐the‐teacher models to improve physical examination and bedside teaching?

A practical limitation of attitude surveys and learner evaluation is the well‐known phenomenon of grade inflation that resulted in high ratings for all attending groups in the studies summarized by Natarajan et al.4 This limits the ability of surveys or evaluations to distinguish truly outstanding teachers and consequently makes it difficult to analyze the attributes of these teachers. We need better tools to detect and learn teaching techniques from great teachers in the clinical environment. We need studies evaluating the effect of teaching hospitalists on learner knowledge or, even more importantly, learner outcomes. Ultimately, we need studies of educational interventions that evaluate the impact of these interventions on patient outcome.

Wright et al.5 provide guidance as they describe the evaluation of a teaching intervention that moves beyond measurement of knowledge or attitudes. The Johns Hopkins Bayview hospitalist group sought to improve the quality of medical consultations performed by hospitalists and by residents rotating on the consultation service using a case‐based teaching module with audits of recent notes. The participants then audited their most recent consultation notes with feedback from the module teacher. The study employed pretests and posttests of knowledgea standard evaluation for educational interventions. This tells us little about the true impact of the teaching module. However, the study then assessed the quality of written consultations done by hospitalists before and after the educational interventions. Scores of consult notes improved significantly after the intervention, although the number of assessments for each physician was limited. Importantly, we need to know if interventions such as this are sustained over time. Wright's well‐established medical education research group's study design assessed the impact of an intervention on physician performance and moves us closer to assessment of the impact on actual patient outcomes. As clinical teachers, we would like to believe that our teaching and our educational innovations are having a positive impact on patient care. Can we demonstrate this?

As academic medical centers contend with further resident work‐hour restrictions proposed by the Institute of Medicine (IOM),10 how will this affect hospitalist teachers? The study by Mazotti et al.3 from the University of California at San Francisco residency program found that about one‐quarter of residents reported spending less time teaching after implementation of the Accreditation Council for Graduate Medical Education (ACGME) duty‐hour restrictions in 2003. Interestingly, those residents reporting less time spent teaching also reported less emotional exhaustion and perceived that they were delivering higher‐quality patient care. This raises a fascinating question for academic hospitalists. Would these findings be similar among teaching hospitalists and nonteaching hospitalists? What about hospitalists who rotate through months of teaching and nonteaching services? Is teaching emotionally exhausting for experienced teachers? A Mayo Clinic study suggested that the extent that faculty physicians are able to engage in work that is most meaningful to them as individuals is a strong determinant of faculty burnout.11 Is the hospitalist who finds teaching most rewarding at risk of burnout if they are assigned only 2 weeks a year as a teaching attending? The answers to these questions will be critical to hospitalist program leaders trying to assure sustainable careers for hospitalists in their programs.

Although the study by Mazotti et al.3 did not assess the impact of the reduction in resident teaching time on the teaching responsibilities for academic hospitalists, previous studies suggest that faculty are also teaching less since the introduction of work‐hour restrictions.12, 13 If the new IOM recommendations are enacted, who will teach? Although the reported experience following the 2003 work‐hour restrictions begs pessimism, the anticipated changes represent an opportunity for creative hospitalist teachers to demonstrate effective adaptations to the changing and compressed inpatient teaching environment.

In summary, this issue of the Journal presents studies that praise the role hospitalists play in teaching the next generation of physicians, but also gives a glimpse of future challenges and opportunities. We should take advantage of hospitalists' central position in clinical education in the hospital to innovate, study the effect on both learner outcomes and patient outcomes, and share our experiences with the hospitalist and medical education communities.

Hospitalists are increasingly assuming a primary role in medical education in the hospital setting, as they also steadily care for a larger portion of hospitalized patients.1 This issue of the Journal of Hospital Medicine highlights the role of hospitalists as teachers in academic medical centers, confirming their expanding and positive role in resident and medical student education. A survey of academic medical centers, a systematic review, an evaluation of the implementation of an educational curriculum, and a survey of residents hint at the challenges hospitalists face in teaching, but also expose us to a more advanced yet facile approach to evaluating the effectiveness of a teaching intervention.25 These publications provoke interesting questions about clinical teaching that hospital medicine educators and researchers should pursue answering. I believe they will also encourage us to innovate in medical education and assessment of that teaching.

Traditionally, teaching attendings for resident teams on medicine or pediatric services rotated through these duties for 1 to 3 months each year, while spending the majority of their time in clinic or research activities. The increasing complexity of hospitalized patients and the pressure to reduce length of stay prompted closer oversight of trainees. With the advent of resident work‐hour restrictions, the need for greater clinical involvement by attending physicians made it increasingly difficult to maintain the traditional model of limited engagement by faculty attendings. Simply put, the dwindling pool of willing and able teaching attendings encouraged teaching hospitals to employ hospitalists to fill the gap in teaching and supervision, as well as clinical coverage.6

Beasley et al.2 report that resident work‐hour restrictions were associated with an increase in the number of teaching hospitals employing hospitalists to 79% of 193 surveyed hospitals in 2007. Of those hospitals with hospitalists, 92% reported that hospitalists serve as attendings on the teaching service. Hospitalists also teach in a number of other venues within these programs, including formal teaching rounds without direct care responsibility, along with delivering didactic lectures and clinical skills education.

How well are teaching hospitalists performing compared to traditional teaching attendings? Natarajan et al.4 provide an important summary of the evidence in a systematic review of studies comparing teaching efforts of hospitalist attendings to those of nonhospitalist attendings. Eight studies from a variety of institutions measured trainee (resident or medical student) attitudes. It is gratifying to learn that hospitalists were generally rated higher at overall teaching effectiveness, provision of feedback, knowledge base, and involvement of the learner in patient care. It seems likely that publication bias would overestimate the positive effect of hospitalists on learner attitudes. However, there are plausible reasons that the positive effect is accurate. Because their professional responsibilities are focused in the hospital, hospitalists should naturally be more available to learners for teaching and feedback. Hospitalists tend to be younger in their academic careers, placing them closer to the cutting edge of knowledge gained during residency and possibly fellowship. They may be more in tune with the needs and pressures faced by their learners, having dealt with these same challenges either during recent training or during nonteaching rotations.

As a relatively young specialty with young and developing academic hospitalists, will the advantage suggested by the Natarajan et al.4 systematic review be sustained over the long term as careers in hospital medicine mature? A 2005 systematic review studying this question among practicing clinicians found, somewhat paradoxically, that older, more experienced clinicians appeared to be at risk for providing lower‐quality care.7 To avoid this decline in clinical effectiveness, hospitalists should proactively seek innovative ways to refresh and update their knowledge and skills throughout their careers. This is particularly critical for teaching physicians. We should seize the opportunity to study the relationship between advancing clinical/teaching experience and educational quality within our teaching programs.

The review by Natarajan et al.4 should also challenge the hospitalist community to achieve even higher levels of proficiency as teachers of medicine. The review alludes to bedside teaching and attention to psychosocial aspects of care as opportunities for improvement by hospitalist teachers. A recent study suggested that physical examination instruction receives declining attention from inpatient teachers and that there are opportunities to increase the amount of bedside teaching.8 A provocative study of inpatients admitted to a teaching service found that physical examination could substantially impact patient care, but that trainees often failed to appreciate significant findings on initial examination.9 How do teaching hospitalists become proficient at physical examination and bedside teaching? Are there models around the country that are successfully developing outstanding clinician educators, incorporating teach‐the‐teacher models to improve physical examination and bedside teaching?

A practical limitation of attitude surveys and learner evaluation is the well‐known phenomenon of grade inflation that resulted in high ratings for all attending groups in the studies summarized by Natarajan et al.4 This limits the ability of surveys or evaluations to distinguish truly outstanding teachers and consequently makes it difficult to analyze the attributes of these teachers. We need better tools to detect and learn teaching techniques from great teachers in the clinical environment. We need studies evaluating the effect of teaching hospitalists on learner knowledge or, even more importantly, learner outcomes. Ultimately, we need studies of educational interventions that evaluate the impact of these interventions on patient outcome.

Wright et al.5 provide guidance as they describe the evaluation of a teaching intervention that moves beyond measurement of knowledge or attitudes. The Johns Hopkins Bayview hospitalist group sought to improve the quality of medical consultations performed by hospitalists and by residents rotating on the consultation service using a case‐based teaching module with audits of recent notes. The participants then audited their most recent consultation notes with feedback from the module teacher. The study employed pretests and posttests of knowledgea standard evaluation for educational interventions. This tells us little about the true impact of the teaching module. However, the study then assessed the quality of written consultations done by hospitalists before and after the educational interventions. Scores of consult notes improved significantly after the intervention, although the number of assessments for each physician was limited. Importantly, we need to know if interventions such as this are sustained over time. Wright's well‐established medical education research group's study design assessed the impact of an intervention on physician performance and moves us closer to assessment of the impact on actual patient outcomes. As clinical teachers, we would like to believe that our teaching and our educational innovations are having a positive impact on patient care. Can we demonstrate this?

As academic medical centers contend with further resident work‐hour restrictions proposed by the Institute of Medicine (IOM),10 how will this affect hospitalist teachers? The study by Mazotti et al.3 from the University of California at San Francisco residency program found that about one‐quarter of residents reported spending less time teaching after implementation of the Accreditation Council for Graduate Medical Education (ACGME) duty‐hour restrictions in 2003. Interestingly, those residents reporting less time spent teaching also reported less emotional exhaustion and perceived that they were delivering higher‐quality patient care. This raises a fascinating question for academic hospitalists. Would these findings be similar among teaching hospitalists and nonteaching hospitalists? What about hospitalists who rotate through months of teaching and nonteaching services? Is teaching emotionally exhausting for experienced teachers? A Mayo Clinic study suggested that the extent that faculty physicians are able to engage in work that is most meaningful to them as individuals is a strong determinant of faculty burnout.11 Is the hospitalist who finds teaching most rewarding at risk of burnout if they are assigned only 2 weeks a year as a teaching attending? The answers to these questions will be critical to hospitalist program leaders trying to assure sustainable careers for hospitalists in their programs.

Although the study by Mazotti et al.3 did not assess the impact of the reduction in resident teaching time on the teaching responsibilities for academic hospitalists, previous studies suggest that faculty are also teaching less since the introduction of work‐hour restrictions.12, 13 If the new IOM recommendations are enacted, who will teach? Although the reported experience following the 2003 work‐hour restrictions begs pessimism, the anticipated changes represent an opportunity for creative hospitalist teachers to demonstrate effective adaptations to the changing and compressed inpatient teaching environment.

In summary, this issue of the Journal presents studies that praise the role hospitalists play in teaching the next generation of physicians, but also gives a glimpse of future challenges and opportunities. We should take advantage of hospitalists' central position in clinical education in the hospital to innovate, study the effect on both learner outcomes and patient outcomes, and share our experiences with the hospitalist and medical education communities.

References
  1. Kuo YF, Sharma G, Freeman JL, Goodwin JS.Growth in the care of older patients by hospitalists in the United States.N Engl J Med.2009;360(11):11021112.
  2. Beasley B, McBride J, McDonald F.Hospitalists involvement in internal medicine residencies.J Hosp Med.2009;4(8):471475.
  3. Mazotti LA, Vidyarthi AR, Wachter RM, Auerbach AD, Katz PP.Impact of duty hour restriction on resident inpatient teaching.J Hosp Med.2009;4(8):476480.
  4. Natarajan P, Ranji SR, Auerbach AD, Hauer KE.Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.J Hosp Med.2009;4(8):490498.
  5. Wright R, Howell E, Landis R, Wright S, Kisuule F, Jordan M.A case‐based teaching module combined with audit and feedback to improve the quality of consultations.J Hosp Med.2009;4(8):486489.
  6. Sehgal NL, Shah HM, Parekh VI, Roy CL, Williams MV.Non‐housestaff medicine services in academic centers: models and challenges.J Hosp Med.2008;3(3):247255.
  7. Choudhry NK, Fletcher RH, Soumerai SB.Systematic review: the relationship between clinical experience and quality of health care.Ann Intern Med.2005;142(4):260273.
  8. Crumlish CM, Yialamas MA, McMahon GT.Quantification of bedside teaching by an academic hospitalist group.J Hosp Med.2009;4(5):304307.
  9. Reilly BM.Physical examination in the care of medical inpatients: an observational study.Lancet.2003;362(9390):11001105.
  10. Institute of Medicine. Resident Duty Hours: Enhancing Sleep, Supervision, and Safety. 2008. Available at: http://www.iom.edu/CMS/3809/48553/60449.aspx. Accessed September2009.
  11. Shanafelt TD, West CP, Sloan JA, et al.Career fit and burnout among academic faculty.Arch Intern Med.2009;169(10):990995.
  12. Harrison R, Allen E.Teaching internal medicine residents in the new era. Inpatient attending with duty‐hour regulations.J Gen Intern Med.2006;21(5):447452.
  13. Goitein L, Shanafelt TD, Nathens AB, Curtis JR.Effects of resident work hour limitations on faculty professional lives.J Gen Intern Med.2008;23(7):10771083.
References
  1. Kuo YF, Sharma G, Freeman JL, Goodwin JS.Growth in the care of older patients by hospitalists in the United States.N Engl J Med.2009;360(11):11021112.
  2. Beasley B, McBride J, McDonald F.Hospitalists involvement in internal medicine residencies.J Hosp Med.2009;4(8):471475.
  3. Mazotti LA, Vidyarthi AR, Wachter RM, Auerbach AD, Katz PP.Impact of duty hour restriction on resident inpatient teaching.J Hosp Med.2009;4(8):476480.
  4. Natarajan P, Ranji SR, Auerbach AD, Hauer KE.Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.J Hosp Med.2009;4(8):490498.
  5. Wright R, Howell E, Landis R, Wright S, Kisuule F, Jordan M.A case‐based teaching module combined with audit and feedback to improve the quality of consultations.J Hosp Med.2009;4(8):486489.
  6. Sehgal NL, Shah HM, Parekh VI, Roy CL, Williams MV.Non‐housestaff medicine services in academic centers: models and challenges.J Hosp Med.2008;3(3):247255.
  7. Choudhry NK, Fletcher RH, Soumerai SB.Systematic review: the relationship between clinical experience and quality of health care.Ann Intern Med.2005;142(4):260273.
  8. Crumlish CM, Yialamas MA, McMahon GT.Quantification of bedside teaching by an academic hospitalist group.J Hosp Med.2009;4(5):304307.
  9. Reilly BM.Physical examination in the care of medical inpatients: an observational study.Lancet.2003;362(9390):11001105.
  10. Institute of Medicine. Resident Duty Hours: Enhancing Sleep, Supervision, and Safety. 2008. Available at: http://www.iom.edu/CMS/3809/48553/60449.aspx. Accessed September2009.
  11. Shanafelt TD, West CP, Sloan JA, et al.Career fit and burnout among academic faculty.Arch Intern Med.2009;169(10):990995.
  12. Harrison R, Allen E.Teaching internal medicine residents in the new era. Inpatient attending with duty‐hour regulations.J Gen Intern Med.2006;21(5):447452.
  13. Goitein L, Shanafelt TD, Nathens AB, Curtis JR.Effects of resident work hour limitations on faculty professional lives.J Gen Intern Med.2008;23(7):10771083.
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JHM's new CME feature—helping hospitalists stay afloat

To study the phenomena of disease without books is to sail an uncharted sea, while to study books without patients is not to go to sea at all.1

‐Sir William Osler

For a typical hospitalist in the 21st century, going to sea is not a concern. Getting lost at sea, or worse yet, drowning, loom larger as threats to today's hospitals‐based providers. To help our readers navigate the rapidly changing waters that are today's hospitals, the Journal is launching a new feature. Starting with this issue of the Journal of Hospital Medicine, we are pleased to provide CME credits pertaining to articles published in the Journal at no additional cost to the reader. As the newly appointed CME Editor, I will be charged with identifying an article to be published in upcoming issues of the Journal that is likely to impact the practice of the majority of our readership. Based on the article, a series of multiple‐choice questions will be developed and readers interested in pursuing CME credit will be directed to an on‐line site to complete the questions and receive immediate CME credit along with the answers to the questions.

For our first article, CME questions have been developed for the well‐done review by Abu Jawdeh and colleagues, Evidence‐based approach for prevention of radiocontrast‐induced nephropathy,2 a topic encountered by hospitalists daily. While clinical topics will likely comprise the majority of selected topics, CME activity in the Journal will reflect the diverse roles filled by hospitalists as champions of quality improvement, patient safety, care transitions, teaching, research, and team leadership.

What may seem straightforward at first glance is actually a more complicated process behind the scenes. The Editorial Office and the production team at Wiley have worked hard to make the CME process as seamless as possible for our readers. User‐friendly features include: direct linking between the on‐line Journal and the Journal's web‐based CME activity; on‐line tracking of individual CME credits and certificates; answers to CME questions, along with explanations, available immediately upon submitting your responses; and performance measurement related to the program. In the future, we hope to take advantage of technology to enhance the CME process to reach our diverse readership. We hope you enjoy this new feature of the Journal, and please give us your feedback on it.

Acknowledgements

The author wishes to acknowledge David Kempe for his careful review and input on this editorial.

References
  1. The Quotable Osler. Silverman ME, Murray TJ and Bryan CS, editors. 1st ed.Philadelphia; PA:American College of Physicians;2003:xi.
  2. Abu Jawdeh B, A,Schelling J.Evidence‐Base Approach for Prevention of radiocontrast induced nephropathy.,J Hosp Med.2009;4(8):499505.
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Journal of Hospital Medicine - 4(8)
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Article PDF
Article PDF

To study the phenomena of disease without books is to sail an uncharted sea, while to study books without patients is not to go to sea at all.1

‐Sir William Osler

For a typical hospitalist in the 21st century, going to sea is not a concern. Getting lost at sea, or worse yet, drowning, loom larger as threats to today's hospitals‐based providers. To help our readers navigate the rapidly changing waters that are today's hospitals, the Journal is launching a new feature. Starting with this issue of the Journal of Hospital Medicine, we are pleased to provide CME credits pertaining to articles published in the Journal at no additional cost to the reader. As the newly appointed CME Editor, I will be charged with identifying an article to be published in upcoming issues of the Journal that is likely to impact the practice of the majority of our readership. Based on the article, a series of multiple‐choice questions will be developed and readers interested in pursuing CME credit will be directed to an on‐line site to complete the questions and receive immediate CME credit along with the answers to the questions.

For our first article, CME questions have been developed for the well‐done review by Abu Jawdeh and colleagues, Evidence‐based approach for prevention of radiocontrast‐induced nephropathy,2 a topic encountered by hospitalists daily. While clinical topics will likely comprise the majority of selected topics, CME activity in the Journal will reflect the diverse roles filled by hospitalists as champions of quality improvement, patient safety, care transitions, teaching, research, and team leadership.

What may seem straightforward at first glance is actually a more complicated process behind the scenes. The Editorial Office and the production team at Wiley have worked hard to make the CME process as seamless as possible for our readers. User‐friendly features include: direct linking between the on‐line Journal and the Journal's web‐based CME activity; on‐line tracking of individual CME credits and certificates; answers to CME questions, along with explanations, available immediately upon submitting your responses; and performance measurement related to the program. In the future, we hope to take advantage of technology to enhance the CME process to reach our diverse readership. We hope you enjoy this new feature of the Journal, and please give us your feedback on it.

Acknowledgements

The author wishes to acknowledge David Kempe for his careful review and input on this editorial.

To study the phenomena of disease without books is to sail an uncharted sea, while to study books without patients is not to go to sea at all.1

‐Sir William Osler

For a typical hospitalist in the 21st century, going to sea is not a concern. Getting lost at sea, or worse yet, drowning, loom larger as threats to today's hospitals‐based providers. To help our readers navigate the rapidly changing waters that are today's hospitals, the Journal is launching a new feature. Starting with this issue of the Journal of Hospital Medicine, we are pleased to provide CME credits pertaining to articles published in the Journal at no additional cost to the reader. As the newly appointed CME Editor, I will be charged with identifying an article to be published in upcoming issues of the Journal that is likely to impact the practice of the majority of our readership. Based on the article, a series of multiple‐choice questions will be developed and readers interested in pursuing CME credit will be directed to an on‐line site to complete the questions and receive immediate CME credit along with the answers to the questions.

For our first article, CME questions have been developed for the well‐done review by Abu Jawdeh and colleagues, Evidence‐based approach for prevention of radiocontrast‐induced nephropathy,2 a topic encountered by hospitalists daily. While clinical topics will likely comprise the majority of selected topics, CME activity in the Journal will reflect the diverse roles filled by hospitalists as champions of quality improvement, patient safety, care transitions, teaching, research, and team leadership.

What may seem straightforward at first glance is actually a more complicated process behind the scenes. The Editorial Office and the production team at Wiley have worked hard to make the CME process as seamless as possible for our readers. User‐friendly features include: direct linking between the on‐line Journal and the Journal's web‐based CME activity; on‐line tracking of individual CME credits and certificates; answers to CME questions, along with explanations, available immediately upon submitting your responses; and performance measurement related to the program. In the future, we hope to take advantage of technology to enhance the CME process to reach our diverse readership. We hope you enjoy this new feature of the Journal, and please give us your feedback on it.

Acknowledgements

The author wishes to acknowledge David Kempe for his careful review and input on this editorial.

References
  1. The Quotable Osler. Silverman ME, Murray TJ and Bryan CS, editors. 1st ed.Philadelphia; PA:American College of Physicians;2003:xi.
  2. Abu Jawdeh B, A,Schelling J.Evidence‐Base Approach for Prevention of radiocontrast induced nephropathy.,J Hosp Med.2009;4(8):499505.
References
  1. The Quotable Osler. Silverman ME, Murray TJ and Bryan CS, editors. 1st ed.Philadelphia; PA:American College of Physicians;2003:xi.
  2. Abu Jawdeh B, A,Schelling J.Evidence‐Base Approach for Prevention of radiocontrast induced nephropathy.,J Hosp Med.2009;4(8):499505.
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Productivity vs. production capacity: Hospitalists as medical educators

Maintaining a balance between productivity (what we do now), and production capacity (the ability to continue to do what we now do in the future) is one of the central tenets of successful organizations and societies. The economic benefits of industrialization (production) must be balanced with the needs of the environment (production capacity). It is appropriate then, that this issue of The Journal of Hospital Medicine juxtaposes Conway's1 article on hospitalists' current production of ensuring value, with articles addressing medical education, our production capacity.

What is the role of hospitalists in medical education? The article by Beasley et al.,2 confirms what has long been suspected: the growth of hospitalists in medical education has paralleled the growth of the movement as a whole. The meta‐analysis by Natarajan et al.3 further suggests that hospitalists are at the very least no worse in medical education than other specialists, and in some domains, may be superior. The theoretical fears of hospitalists as medical educators have not been borne out: utilizing hospitalists as educators does not lead to a decline in resident autonomy, nor does it lead to a decline in educational ability. But despite the fact that 73% of residency training programs utilize hospitalists, there are several reasons why the hospitalists' role in inpatient medical education should be even more robust.

The landscape of graduate medical education has dramatically changed in the past 10 years. The knowledge‐only paradigm has evolved to a comprehensive focus on the trainee's overall performance, including understanding the healthcare system in which she works (systems of care), self‐reflection on her practice (practice‐based learning), and an augmented emphasis on professionalism and interpersonal skills.4 Unfortunately, many systems have not undergone a similar paradigm change, opting instead to merely rearrange components of the old knowledge‐focused system. For example, practice‐based learning may remain relegated to journal clubs, where the focus is on the knowledge contained in the chosen article, instead of active exercises in which the resident self‐reflects on his patient care performance and seeks ways to improve that performance. Instruction in systems‐of‐care may remain within a knowledge‐only paradigm: a didactic lecture on Medicare/Medicaid and reimbursement instead of residents actively participating in quality improvement projects.

The article by Mazotti et al.,5 provides insight into the reason for this developmental arrest: there isn't enough time in the old system. The duty‐hours have decreased for residents, but since the work product has remained the same, the result has been an increase in work intensity. As work intensity increases, production capacity (medical education) is the first to be sacrificed in an effort to maintain production (getting the work done).

Here is the yet unrealized role of the hospitalist. The same degree of systems reengineering that brought about improved efficiency in patient care (shorter lengths of stay, fewer readmissions), must be applied to the inpatient education system if duty hours, a reasonable work intensity, and meaningful education in each of the core competencies are to coexist. But there is no panacea for these issues: each system is unique, and the solutions to improving the efficiency of the inpatient education environment are just as unique. Solutions require a systems architect (ie, the hospitalist) to redesign the educational environment in his particular system. It is natural to assume that the hospitalist educator, familiar with the strengths and weakness of the educational system in which he routinely works, will be best equipped to enact meaningful solutions that improve efficiency while protecting the principles of medical education.

What does it mean to change the educational system? Taiichi Ohno,6 Toyota's Chief Engineer, provides Seven Organizational Wastes, a framework for identifying areas of improvement in the educational work environment. Consider, for example, the following selected opportunities for improving the efficiency of the inpatient medical education system: (1) excessive testing or consultation leading to delayed discharge and more resident work effort (Overproduction); (2) the resident team waiting for the attending to arrive from a procedure or clinic (Waiting); (3) inadequate teaching about the principles of transitions of care, resulting in more readmissions to the teaching service (Transporting); (4) failure to have quality improvement conferences to discuss the appropriateness of admissions (Inappropriate processing); (5) failure to teach residents how to work with social work/placement services to facilitate early discharge (Unnecessary inventory); (6) failure to construct a training program that limits fragmentation, with residents moving from 1 task to the next and back again (Unnecessary motion); and (7) medical errors resulting in prolonged lengths of stay and resident work effort (Defects). There is no shortage of opportunities for improving the efficiency of the inpatient educational environment, but it requires that the systems architect is sufficiently familiar with the system to design interventions that are meaningful and effective. This is the unique advantage of the hospitalist.

But the greatest risk to inpatient medical education is yet to come, and it may be on the hospitalist's shoulders to reverse a dangerous trend. With the advent of more extensive electronic medical records, the locus of patient care has begun to shift from the bedside to a computer terminal. An unbridled drive to efficiency, without a steward to ensure the primacy of patient‐centered care, is likely to inspire the next generation of physicians to see Mr. A. Huxley as the i‐Patient, in which the entirety of his management is conducted from the safety of a computer terminal.7 Despite the need for efficiency, the patient has to remain the focal point. It is at the bedside that the resident learns that observing 5 bags of potato chips on the nightstand might obviate a million‐dollar workup for refractory hypertension. And it is at the bedside that the resident learns that despite our elaborate protocols and decision analyses, the ultimate testing and management decisions hinge upon the patient's preferences. The single best thing than can be done to augment patient safety and quality is to maximize the time the patient spends with his healthcare team; and the hospitalist, who is not in a rush to complete morning rounds in an effort to get to a clinic or an endoscopy suite, may be the person who has the time to prioritize bedside rounds as a part of the educational environment.

The article by Nazario8 establishes the urgency of integrating the humanities into patient management. For meaningful humanities instruction to occur, however, it has to occur at the bedside, not in the classroom. And this requires that the supervising physician has the time to reflect with the resident upon the humanism issues that are unique to each patient encounter. Once again, it is time that enables the luxury of this self‐reflection, a commodity that the hospitalist enjoys as a part of her job description. It is also a commodity that the hospitalist can generate by augmenting efficiency in the educational system, provided patient‐centered care remains the priority.

The role of the hospitalist has to be much more than merely patching the current paradigm of graduate medical education. Overseeing nonteaching services and serving as the night float physician are examples of these patches. While valuable, these roles are useful only in preserving production of the current system, not in enabling production capacity for the next generation of physicians. Continuing in this role without also becoming an active part of the teaching service sends a message to residents that a career as a hospitalist in a teaching environment is only to be a fourth‐year or fifth‐year resident. Why would any resident embark upon that career? Meeting the demand for 30,000 hospitalists by 2012 requires a pipeline of physicians, and answering this question will be central to achieving that goal. Residents must have hospitalist role models, occupying careers devoted to patient safety and quality; careers that are meaningful and fulfilling.

To this end, the hospital medicine community cannot be satisfied with being no worse than other specialists in medical education. As Natarajan et al.3 point out, the evaluation of inpatient medical education has, with few exceptions, been solely based upon learner's subjective opinions. Meaningful change in the educational system will require meaningful objective endpoints: participation in the quality improvement projects; patient‐centered evaluations of resident performance; end‐user evaluations of resident communication skills (clinic physicians, nurses, other services); metrics to assess the efficacy of the transition of care; and resident profiles that enable self‐assessment of their practice. It will be up to the hospitalist to assess the system to define these meaningful endpoints that ensure that inpatient education is advancing quality, safety, and patient‐centered care.

Despite all of the reasons for why hospitalists should be more involved in the teaching service, there remains the 1 reason that they are not: hospitalists on average are young, and they may not have the teaching skills that more experienced generalists or subspecialists possess. To bring about the benefits hospitalists can offer to the inpatient education environment, hospitalists must be willing to compensate for their lack of teaching experience by seeking out formal training courses in medical education. The Academic Hospitalist Academy cosponsored by the Society of Hospital Medicine (SHM), the Society of General Internal Medicine (SGIM), and the Association of Chiefs of General Internal Medicine (ACGIM) is 1 example.9

As experience is accumulated, more hospitalists have to actively seek out leadership positions in graduate medical education, aligning our strengths, in patient safety, efficiency, and systems change, with the goals and objectives of the residency and student programs. The fact that 73% of residency training programs utilize hospitalists is exciting; the fact that there are only 15 hospitalists as program directors is disappointing.2 As was the case in the clinical care environment, leadership will be just as important in the education environment, as it is important for enacting the changes that will transform the inpatient education environment to a system that is efficient, safe, and patient‐centered.

Hospitalists have been effective in their production, augmenting efficiency and quality of patient care. But the reality is that the task of ensuring value, as it pertains to patient safety and quality, is too onerous of a task to be accomplished with arithmetic gains. Generations of physicians will have to adopt a cultural change to reach the ultimate goal. It is of little consequence that we improve safety for a moment in time, only to have it fall by the wayside as successive generations of physicians take our place. Now is the time for hospitalists to fully embrace the inpatient education environment as our responsibility. Too much time has already been wasted in arguing against duty‐hours regulations. These regulations are now here to stay, and this has created a system that is currently unable to handle the strains of multiple demands. Only by using the hospitalist's expertise in systems improvements and efficiency will a new inpatient educational system evolve; one that is efficient, safe, and patient‐focused, thus ensuring current production. And also one that enables meaningful development of communication, practice‐based learning, and systems‐of‐care skills, ensuring our production capacity for years to come.

References
  1. Conway PH.Value‐driven health care: implications for hospitals and hospitalists.J Hosp Med.2009;4(8):507511.
  2. Beasley BW, McBride J, McDonald FS.Hospitalists involvement in internal medicine residencies.J Hosp Med.2009;4(8):471475.
  3. Natarajan P, Ranji S, Auerbach A, Hauer K.Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.J Hosp Med.2009;4(8):490498.
  4. Accreditation Council for Graduate Medical Education (ACGME). Internal Medicine Program Requirements. Available at: http://www.acgme.org/acWebsite/RRC_140/140_prIndex.asp. Accessed August2009.
  5. Mazotti LA, Vidyarthi AR, Wachter RM, Auerbach AD, Katz PP.Impact of duty hour restriction on resident inpatient teaching.J Hosp Med.2009;4(8):476480.
  6. Ohno T.Just‐In‐Time for Today and Tomorrow.New York, NY:Productivity Press;1988.
  7. Verghese A.Culture shock: patient as icon, icon as patient.N Engl J Med.2008;359:27482751.
  8. Nazario R.The Medical humanities as tools for the teaching of patient‐centered care.J Hosp Med.2009;4(8):512514.
  9. Society of General Internal Medicine (SGIM). The Academic Hospitalist Academy. Available at: http://www.sgim.org/index.cfm?pageId=815. Accessed August2009.
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Maintaining a balance between productivity (what we do now), and production capacity (the ability to continue to do what we now do in the future) is one of the central tenets of successful organizations and societies. The economic benefits of industrialization (production) must be balanced with the needs of the environment (production capacity). It is appropriate then, that this issue of The Journal of Hospital Medicine juxtaposes Conway's1 article on hospitalists' current production of ensuring value, with articles addressing medical education, our production capacity.

What is the role of hospitalists in medical education? The article by Beasley et al.,2 confirms what has long been suspected: the growth of hospitalists in medical education has paralleled the growth of the movement as a whole. The meta‐analysis by Natarajan et al.3 further suggests that hospitalists are at the very least no worse in medical education than other specialists, and in some domains, may be superior. The theoretical fears of hospitalists as medical educators have not been borne out: utilizing hospitalists as educators does not lead to a decline in resident autonomy, nor does it lead to a decline in educational ability. But despite the fact that 73% of residency training programs utilize hospitalists, there are several reasons why the hospitalists' role in inpatient medical education should be even more robust.

The landscape of graduate medical education has dramatically changed in the past 10 years. The knowledge‐only paradigm has evolved to a comprehensive focus on the trainee's overall performance, including understanding the healthcare system in which she works (systems of care), self‐reflection on her practice (practice‐based learning), and an augmented emphasis on professionalism and interpersonal skills.4 Unfortunately, many systems have not undergone a similar paradigm change, opting instead to merely rearrange components of the old knowledge‐focused system. For example, practice‐based learning may remain relegated to journal clubs, where the focus is on the knowledge contained in the chosen article, instead of active exercises in which the resident self‐reflects on his patient care performance and seeks ways to improve that performance. Instruction in systems‐of‐care may remain within a knowledge‐only paradigm: a didactic lecture on Medicare/Medicaid and reimbursement instead of residents actively participating in quality improvement projects.

The article by Mazotti et al.,5 provides insight into the reason for this developmental arrest: there isn't enough time in the old system. The duty‐hours have decreased for residents, but since the work product has remained the same, the result has been an increase in work intensity. As work intensity increases, production capacity (medical education) is the first to be sacrificed in an effort to maintain production (getting the work done).

Here is the yet unrealized role of the hospitalist. The same degree of systems reengineering that brought about improved efficiency in patient care (shorter lengths of stay, fewer readmissions), must be applied to the inpatient education system if duty hours, a reasonable work intensity, and meaningful education in each of the core competencies are to coexist. But there is no panacea for these issues: each system is unique, and the solutions to improving the efficiency of the inpatient education environment are just as unique. Solutions require a systems architect (ie, the hospitalist) to redesign the educational environment in his particular system. It is natural to assume that the hospitalist educator, familiar with the strengths and weakness of the educational system in which he routinely works, will be best equipped to enact meaningful solutions that improve efficiency while protecting the principles of medical education.

What does it mean to change the educational system? Taiichi Ohno,6 Toyota's Chief Engineer, provides Seven Organizational Wastes, a framework for identifying areas of improvement in the educational work environment. Consider, for example, the following selected opportunities for improving the efficiency of the inpatient medical education system: (1) excessive testing or consultation leading to delayed discharge and more resident work effort (Overproduction); (2) the resident team waiting for the attending to arrive from a procedure or clinic (Waiting); (3) inadequate teaching about the principles of transitions of care, resulting in more readmissions to the teaching service (Transporting); (4) failure to have quality improvement conferences to discuss the appropriateness of admissions (Inappropriate processing); (5) failure to teach residents how to work with social work/placement services to facilitate early discharge (Unnecessary inventory); (6) failure to construct a training program that limits fragmentation, with residents moving from 1 task to the next and back again (Unnecessary motion); and (7) medical errors resulting in prolonged lengths of stay and resident work effort (Defects). There is no shortage of opportunities for improving the efficiency of the inpatient educational environment, but it requires that the systems architect is sufficiently familiar with the system to design interventions that are meaningful and effective. This is the unique advantage of the hospitalist.

But the greatest risk to inpatient medical education is yet to come, and it may be on the hospitalist's shoulders to reverse a dangerous trend. With the advent of more extensive electronic medical records, the locus of patient care has begun to shift from the bedside to a computer terminal. An unbridled drive to efficiency, without a steward to ensure the primacy of patient‐centered care, is likely to inspire the next generation of physicians to see Mr. A. Huxley as the i‐Patient, in which the entirety of his management is conducted from the safety of a computer terminal.7 Despite the need for efficiency, the patient has to remain the focal point. It is at the bedside that the resident learns that observing 5 bags of potato chips on the nightstand might obviate a million‐dollar workup for refractory hypertension. And it is at the bedside that the resident learns that despite our elaborate protocols and decision analyses, the ultimate testing and management decisions hinge upon the patient's preferences. The single best thing than can be done to augment patient safety and quality is to maximize the time the patient spends with his healthcare team; and the hospitalist, who is not in a rush to complete morning rounds in an effort to get to a clinic or an endoscopy suite, may be the person who has the time to prioritize bedside rounds as a part of the educational environment.

The article by Nazario8 establishes the urgency of integrating the humanities into patient management. For meaningful humanities instruction to occur, however, it has to occur at the bedside, not in the classroom. And this requires that the supervising physician has the time to reflect with the resident upon the humanism issues that are unique to each patient encounter. Once again, it is time that enables the luxury of this self‐reflection, a commodity that the hospitalist enjoys as a part of her job description. It is also a commodity that the hospitalist can generate by augmenting efficiency in the educational system, provided patient‐centered care remains the priority.

The role of the hospitalist has to be much more than merely patching the current paradigm of graduate medical education. Overseeing nonteaching services and serving as the night float physician are examples of these patches. While valuable, these roles are useful only in preserving production of the current system, not in enabling production capacity for the next generation of physicians. Continuing in this role without also becoming an active part of the teaching service sends a message to residents that a career as a hospitalist in a teaching environment is only to be a fourth‐year or fifth‐year resident. Why would any resident embark upon that career? Meeting the demand for 30,000 hospitalists by 2012 requires a pipeline of physicians, and answering this question will be central to achieving that goal. Residents must have hospitalist role models, occupying careers devoted to patient safety and quality; careers that are meaningful and fulfilling.

To this end, the hospital medicine community cannot be satisfied with being no worse than other specialists in medical education. As Natarajan et al.3 point out, the evaluation of inpatient medical education has, with few exceptions, been solely based upon learner's subjective opinions. Meaningful change in the educational system will require meaningful objective endpoints: participation in the quality improvement projects; patient‐centered evaluations of resident performance; end‐user evaluations of resident communication skills (clinic physicians, nurses, other services); metrics to assess the efficacy of the transition of care; and resident profiles that enable self‐assessment of their practice. It will be up to the hospitalist to assess the system to define these meaningful endpoints that ensure that inpatient education is advancing quality, safety, and patient‐centered care.

Despite all of the reasons for why hospitalists should be more involved in the teaching service, there remains the 1 reason that they are not: hospitalists on average are young, and they may not have the teaching skills that more experienced generalists or subspecialists possess. To bring about the benefits hospitalists can offer to the inpatient education environment, hospitalists must be willing to compensate for their lack of teaching experience by seeking out formal training courses in medical education. The Academic Hospitalist Academy cosponsored by the Society of Hospital Medicine (SHM), the Society of General Internal Medicine (SGIM), and the Association of Chiefs of General Internal Medicine (ACGIM) is 1 example.9

As experience is accumulated, more hospitalists have to actively seek out leadership positions in graduate medical education, aligning our strengths, in patient safety, efficiency, and systems change, with the goals and objectives of the residency and student programs. The fact that 73% of residency training programs utilize hospitalists is exciting; the fact that there are only 15 hospitalists as program directors is disappointing.2 As was the case in the clinical care environment, leadership will be just as important in the education environment, as it is important for enacting the changes that will transform the inpatient education environment to a system that is efficient, safe, and patient‐centered.

Hospitalists have been effective in their production, augmenting efficiency and quality of patient care. But the reality is that the task of ensuring value, as it pertains to patient safety and quality, is too onerous of a task to be accomplished with arithmetic gains. Generations of physicians will have to adopt a cultural change to reach the ultimate goal. It is of little consequence that we improve safety for a moment in time, only to have it fall by the wayside as successive generations of physicians take our place. Now is the time for hospitalists to fully embrace the inpatient education environment as our responsibility. Too much time has already been wasted in arguing against duty‐hours regulations. These regulations are now here to stay, and this has created a system that is currently unable to handle the strains of multiple demands. Only by using the hospitalist's expertise in systems improvements and efficiency will a new inpatient educational system evolve; one that is efficient, safe, and patient‐focused, thus ensuring current production. And also one that enables meaningful development of communication, practice‐based learning, and systems‐of‐care skills, ensuring our production capacity for years to come.

Maintaining a balance between productivity (what we do now), and production capacity (the ability to continue to do what we now do in the future) is one of the central tenets of successful organizations and societies. The economic benefits of industrialization (production) must be balanced with the needs of the environment (production capacity). It is appropriate then, that this issue of The Journal of Hospital Medicine juxtaposes Conway's1 article on hospitalists' current production of ensuring value, with articles addressing medical education, our production capacity.

What is the role of hospitalists in medical education? The article by Beasley et al.,2 confirms what has long been suspected: the growth of hospitalists in medical education has paralleled the growth of the movement as a whole. The meta‐analysis by Natarajan et al.3 further suggests that hospitalists are at the very least no worse in medical education than other specialists, and in some domains, may be superior. The theoretical fears of hospitalists as medical educators have not been borne out: utilizing hospitalists as educators does not lead to a decline in resident autonomy, nor does it lead to a decline in educational ability. But despite the fact that 73% of residency training programs utilize hospitalists, there are several reasons why the hospitalists' role in inpatient medical education should be even more robust.

The landscape of graduate medical education has dramatically changed in the past 10 years. The knowledge‐only paradigm has evolved to a comprehensive focus on the trainee's overall performance, including understanding the healthcare system in which she works (systems of care), self‐reflection on her practice (practice‐based learning), and an augmented emphasis on professionalism and interpersonal skills.4 Unfortunately, many systems have not undergone a similar paradigm change, opting instead to merely rearrange components of the old knowledge‐focused system. For example, practice‐based learning may remain relegated to journal clubs, where the focus is on the knowledge contained in the chosen article, instead of active exercises in which the resident self‐reflects on his patient care performance and seeks ways to improve that performance. Instruction in systems‐of‐care may remain within a knowledge‐only paradigm: a didactic lecture on Medicare/Medicaid and reimbursement instead of residents actively participating in quality improvement projects.

The article by Mazotti et al.,5 provides insight into the reason for this developmental arrest: there isn't enough time in the old system. The duty‐hours have decreased for residents, but since the work product has remained the same, the result has been an increase in work intensity. As work intensity increases, production capacity (medical education) is the first to be sacrificed in an effort to maintain production (getting the work done).

Here is the yet unrealized role of the hospitalist. The same degree of systems reengineering that brought about improved efficiency in patient care (shorter lengths of stay, fewer readmissions), must be applied to the inpatient education system if duty hours, a reasonable work intensity, and meaningful education in each of the core competencies are to coexist. But there is no panacea for these issues: each system is unique, and the solutions to improving the efficiency of the inpatient education environment are just as unique. Solutions require a systems architect (ie, the hospitalist) to redesign the educational environment in his particular system. It is natural to assume that the hospitalist educator, familiar with the strengths and weakness of the educational system in which he routinely works, will be best equipped to enact meaningful solutions that improve efficiency while protecting the principles of medical education.

What does it mean to change the educational system? Taiichi Ohno,6 Toyota's Chief Engineer, provides Seven Organizational Wastes, a framework for identifying areas of improvement in the educational work environment. Consider, for example, the following selected opportunities for improving the efficiency of the inpatient medical education system: (1) excessive testing or consultation leading to delayed discharge and more resident work effort (Overproduction); (2) the resident team waiting for the attending to arrive from a procedure or clinic (Waiting); (3) inadequate teaching about the principles of transitions of care, resulting in more readmissions to the teaching service (Transporting); (4) failure to have quality improvement conferences to discuss the appropriateness of admissions (Inappropriate processing); (5) failure to teach residents how to work with social work/placement services to facilitate early discharge (Unnecessary inventory); (6) failure to construct a training program that limits fragmentation, with residents moving from 1 task to the next and back again (Unnecessary motion); and (7) medical errors resulting in prolonged lengths of stay and resident work effort (Defects). There is no shortage of opportunities for improving the efficiency of the inpatient educational environment, but it requires that the systems architect is sufficiently familiar with the system to design interventions that are meaningful and effective. This is the unique advantage of the hospitalist.

But the greatest risk to inpatient medical education is yet to come, and it may be on the hospitalist's shoulders to reverse a dangerous trend. With the advent of more extensive electronic medical records, the locus of patient care has begun to shift from the bedside to a computer terminal. An unbridled drive to efficiency, without a steward to ensure the primacy of patient‐centered care, is likely to inspire the next generation of physicians to see Mr. A. Huxley as the i‐Patient, in which the entirety of his management is conducted from the safety of a computer terminal.7 Despite the need for efficiency, the patient has to remain the focal point. It is at the bedside that the resident learns that observing 5 bags of potato chips on the nightstand might obviate a million‐dollar workup for refractory hypertension. And it is at the bedside that the resident learns that despite our elaborate protocols and decision analyses, the ultimate testing and management decisions hinge upon the patient's preferences. The single best thing than can be done to augment patient safety and quality is to maximize the time the patient spends with his healthcare team; and the hospitalist, who is not in a rush to complete morning rounds in an effort to get to a clinic or an endoscopy suite, may be the person who has the time to prioritize bedside rounds as a part of the educational environment.

The article by Nazario8 establishes the urgency of integrating the humanities into patient management. For meaningful humanities instruction to occur, however, it has to occur at the bedside, not in the classroom. And this requires that the supervising physician has the time to reflect with the resident upon the humanism issues that are unique to each patient encounter. Once again, it is time that enables the luxury of this self‐reflection, a commodity that the hospitalist enjoys as a part of her job description. It is also a commodity that the hospitalist can generate by augmenting efficiency in the educational system, provided patient‐centered care remains the priority.

The role of the hospitalist has to be much more than merely patching the current paradigm of graduate medical education. Overseeing nonteaching services and serving as the night float physician are examples of these patches. While valuable, these roles are useful only in preserving production of the current system, not in enabling production capacity for the next generation of physicians. Continuing in this role without also becoming an active part of the teaching service sends a message to residents that a career as a hospitalist in a teaching environment is only to be a fourth‐year or fifth‐year resident. Why would any resident embark upon that career? Meeting the demand for 30,000 hospitalists by 2012 requires a pipeline of physicians, and answering this question will be central to achieving that goal. Residents must have hospitalist role models, occupying careers devoted to patient safety and quality; careers that are meaningful and fulfilling.

To this end, the hospital medicine community cannot be satisfied with being no worse than other specialists in medical education. As Natarajan et al.3 point out, the evaluation of inpatient medical education has, with few exceptions, been solely based upon learner's subjective opinions. Meaningful change in the educational system will require meaningful objective endpoints: participation in the quality improvement projects; patient‐centered evaluations of resident performance; end‐user evaluations of resident communication skills (clinic physicians, nurses, other services); metrics to assess the efficacy of the transition of care; and resident profiles that enable self‐assessment of their practice. It will be up to the hospitalist to assess the system to define these meaningful endpoints that ensure that inpatient education is advancing quality, safety, and patient‐centered care.

Despite all of the reasons for why hospitalists should be more involved in the teaching service, there remains the 1 reason that they are not: hospitalists on average are young, and they may not have the teaching skills that more experienced generalists or subspecialists possess. To bring about the benefits hospitalists can offer to the inpatient education environment, hospitalists must be willing to compensate for their lack of teaching experience by seeking out formal training courses in medical education. The Academic Hospitalist Academy cosponsored by the Society of Hospital Medicine (SHM), the Society of General Internal Medicine (SGIM), and the Association of Chiefs of General Internal Medicine (ACGIM) is 1 example.9

As experience is accumulated, more hospitalists have to actively seek out leadership positions in graduate medical education, aligning our strengths, in patient safety, efficiency, and systems change, with the goals and objectives of the residency and student programs. The fact that 73% of residency training programs utilize hospitalists is exciting; the fact that there are only 15 hospitalists as program directors is disappointing.2 As was the case in the clinical care environment, leadership will be just as important in the education environment, as it is important for enacting the changes that will transform the inpatient education environment to a system that is efficient, safe, and patient‐centered.

Hospitalists have been effective in their production, augmenting efficiency and quality of patient care. But the reality is that the task of ensuring value, as it pertains to patient safety and quality, is too onerous of a task to be accomplished with arithmetic gains. Generations of physicians will have to adopt a cultural change to reach the ultimate goal. It is of little consequence that we improve safety for a moment in time, only to have it fall by the wayside as successive generations of physicians take our place. Now is the time for hospitalists to fully embrace the inpatient education environment as our responsibility. Too much time has already been wasted in arguing against duty‐hours regulations. These regulations are now here to stay, and this has created a system that is currently unable to handle the strains of multiple demands. Only by using the hospitalist's expertise in systems improvements and efficiency will a new inpatient educational system evolve; one that is efficient, safe, and patient‐focused, thus ensuring current production. And also one that enables meaningful development of communication, practice‐based learning, and systems‐of‐care skills, ensuring our production capacity for years to come.

References
  1. Conway PH.Value‐driven health care: implications for hospitals and hospitalists.J Hosp Med.2009;4(8):507511.
  2. Beasley BW, McBride J, McDonald FS.Hospitalists involvement in internal medicine residencies.J Hosp Med.2009;4(8):471475.
  3. Natarajan P, Ranji S, Auerbach A, Hauer K.Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.J Hosp Med.2009;4(8):490498.
  4. Accreditation Council for Graduate Medical Education (ACGME). Internal Medicine Program Requirements. Available at: http://www.acgme.org/acWebsite/RRC_140/140_prIndex.asp. Accessed August2009.
  5. Mazotti LA, Vidyarthi AR, Wachter RM, Auerbach AD, Katz PP.Impact of duty hour restriction on resident inpatient teaching.J Hosp Med.2009;4(8):476480.
  6. Ohno T.Just‐In‐Time for Today and Tomorrow.New York, NY:Productivity Press;1988.
  7. Verghese A.Culture shock: patient as icon, icon as patient.N Engl J Med.2008;359:27482751.
  8. Nazario R.The Medical humanities as tools for the teaching of patient‐centered care.J Hosp Med.2009;4(8):512514.
  9. Society of General Internal Medicine (SGIM). The Academic Hospitalist Academy. Available at: http://www.sgim.org/index.cfm?pageId=815. Accessed August2009.
References
  1. Conway PH.Value‐driven health care: implications for hospitals and hospitalists.J Hosp Med.2009;4(8):507511.
  2. Beasley BW, McBride J, McDonald FS.Hospitalists involvement in internal medicine residencies.J Hosp Med.2009;4(8):471475.
  3. Natarajan P, Ranji S, Auerbach A, Hauer K.Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.J Hosp Med.2009;4(8):490498.
  4. Accreditation Council for Graduate Medical Education (ACGME). Internal Medicine Program Requirements. Available at: http://www.acgme.org/acWebsite/RRC_140/140_prIndex.asp. Accessed August2009.
  5. Mazotti LA, Vidyarthi AR, Wachter RM, Auerbach AD, Katz PP.Impact of duty hour restriction on resident inpatient teaching.J Hosp Med.2009;4(8):476480.
  6. Ohno T.Just‐In‐Time for Today and Tomorrow.New York, NY:Productivity Press;1988.
  7. Verghese A.Culture shock: patient as icon, icon as patient.N Engl J Med.2008;359:27482751.
  8. Nazario R.The Medical humanities as tools for the teaching of patient‐centered care.J Hosp Med.2009;4(8):512514.
  9. Society of General Internal Medicine (SGIM). The Academic Hospitalist Academy. Available at: http://www.sgim.org/index.cfm?pageId=815. Accessed August2009.
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Productivity vs. production capacity: Hospitalists as medical educators
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Simulator Training of Future Hospitalists

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Training future hospitalists with simulators: A needed step toward accessible, expertly performed bedside procedures

Internal medicine residency programs, the major pipeline for incoming hospitalists, often provide little hands‐on experience in bedside procedures. Some residents may only insert 1 central venous catheter every 4 months on the general medicine wards,1 and others may gain little more experience during intensive care unit rotations. As seen in the survey presented by Grover et al.2 in this issue of the Journal, after 3 years of training in all types of patient care units, residents often count their accumulated experience on their fingers and toes. Such sparse experience hardly leads to expertise. Recognizing this pervasive lack of training the American Board of Internal Medicine narrowed its certification requirements for bedside procedures in 2006.3 Residents are no longer expected to perform bedside procedures but instead to know them. This important revision acknowledges that manual skills training should neither be assumed nor expendablecontinuing to do so is too risky.4 Yet as internal medicine residency programs focus their bedside procedure training on cognitive competence, the ongoing exodus of bedside procedures to the up‐market hands of subspecialists, surgeons, anesthesiologists, and interventional radiologists5 will likely accelerate.

But why should hospitalists disrupt this trend? Bedside procedures are common and not always conveniently needed during daytime hours. Roughly one‐tenth of general medicine inpatients receive a central venous catheter (CVC) insertion, a lumbar puncture, an abdominal paracentesis, or a thoracentesis.6 Among these patients, about one‐half will urgently need procedures during off‐hours. Outside of the emergency department, hospitalists will likely remain the only group of physicians available at the bedsides of general medicine inpatients 7 days a week, 24 hours per day. Thus, in developing our particular practice system to best serve our patients,7 we believe that hospitalists ought to remain principals in ensuring that inpatients have ready access to expertly performed bedside procedures.

Yet unfortunately, given the limited training in manual skills that today's internal medicine residents receive, hospitalists are increasingly less prepared to provide this access themselves.8 State‐of‐the‐art training methods developed by medical specialties that depend largely on manual skills provide promising potential solutions for both future and practicing hospitalists.9 In particular, patient simulators can provide trainees with the essential hands‐on experience they often lack. In contrast to the ad hoc see‐one, do‐one, teach‐one method in current widespread use, training with simulators has distinct advantages. First, simulators obviate the increasingly awkward consent as patients grow savvier about safety concerns and (understandably) less tolerant of a novice's need to acquire experience.10 Second, training with simulators is controlled so that anatomic variations, comorbidities, patient discomfort, and time pressuresthough important real‐world factorscan be artificially removed in the earlier cognitive and integrative stages of training.11 Third, immediate feedback, which at the bedside of real patients is often empathetically avoided or delivered in cryptic hand signals, can be unmistakably unmuted and honest in the simulator setting. Fourth, and most important to the development of expertise, simulators can be used repeatedly, allowing trainees first to become facile in the mechanics of their performance (eg, holding an ultrasound probe for real‐time guidance or knowing how it feels to enter a vein) before attempting a procedure on a patient.

Three examples of patient simulators used to train internal medicine residents in CVC insertion are presented in this issue of the Journal.1214 Using observers who adhered to objective, a priori assessment criteria, both Rosen et al.13 and Millington et al.14 carefully demonstrate that internal medicine residents' manual skills can improve with patient simulators. Given the understood importance of hands‐on experience in manual skills training,15 these anticipated findings are important validations of simulator theory. The work by Barsuk et al.12 goes further to begin to examine whether or not simulator training actually leads to improved patient outcomesthe holy grail of such research. In this observational study, compared to residents who did not undergo simulator training, those who did undergo such training had 1 fewer needle passes during successful CVC insertions. Given the relative infrequency of periprocedural complications, this study was understandably underpowered to measure true complications, relying instead on the often‐used surrogate of needle passes. Nonetheless, this work will serve as an important initial example of why simulator training may be worth the effort.

To direct participation in simulator training, we endorse selecting trainees who will perform bedside procedures in their future practice.16 Given the trend in manual skills training among internal medicine residency training programs, hospitalist programs may need to shoulder this effort themselves. Thankfully, simulator training need not be expensive. Based on transfer‐of‐learning research,17 the fidelity of the simulator is less important than the accumulated experience it can afford. Even low‐fidelity simulators, such as the store‐bought whole chicken used by Rosen et al.,13 may preserve trainees' manual skills just as effectively as the expensive, bionic, high‐fidelity simulators used by Barsuk et al.12 and Millington et al.14

Beyond the costs of training, however, hospital administrators and hospitalist group leaders have more complex externalities and opportunity costs to weigh when evaluating which physician groups should perform bedside procedures. The intuitively lower‐cost strategy for hospitals, we believe, would be to ask hospitalists to perform bedside procedures at patients' bedsides instead of asking, say, highly‐paid interventional radiologists to perform the same procedures in fully‐staffed fluoroscopy suites. There is, however, very little research to help inform these decisions. As hospitalists, we know firsthand that modern healthcare remuneration is based more on doing than on knowing. Yet, whether or not bedside procedures afford financial incentives for hospitalists is unclearmuch will depend on local factors. Regardless of the finances, we believe that hospitalists skilled in performing common bedside procedures can improve the quality and efficiency of care delivery at patients' bedsides. So, instead of a call to arms for yet another turf battle, let's continue development of state‐of‐the‐art training methods like simulators to ensure that future hospitalists can expertly perform bedside procedures. After all, fighting for improvements in patient safety is a battle that we hospitalists know how to win.

References
  1. Miranda JA,Trick WE,Evans AT,Charles‐Damte M,Reilly BM,Clarke P.Firm‐based trial to improve central venous catheter insertion practices.J Hosp Med.2007;2:135142.
  2. Grover S,Currier P,Elinoff J,Mouchantaf K,Katz J,McMahon G.Development of a test to evaluate residents' knowledge of medical procedures.J Hosp Med.2009;XX:XXXXXX.
  3. American Board of Internal Medicine. Policies and procedures for certification, May 2009. Available at: http://www.abim.org/default.aspx; Accessed August2009.
  4. Fincher RM.Procedural competence of internal medicine residents: time to address the gap.J Gen Intern Med.2000;15:432433.
  5. Wigton RS,Alguire P.The declining number and variety of procedures done by general internists: a resurvey of members of the American College of Physicians.Ann Intern Med.2007;146:355360.
  6. Lucas BP,Asbury JK,Wang Y, et al.Impact of a bedside procedure service on general medicine inpatients: a firm‐based trial.J Hosp Med.2006;2:143149.
  7. Duffy FD,Holmboe ES.What procedures should internists do?Ann Intern Med.2007;146:392394.
  8. Huang GC,Smith CC,Gordon CE, et al.Beyond the comfort zone: residents assess their comfort performing inpatient medical procedures.Am J Med.2006;119:71.e17e24
  9. Reznick RK,MacRae H.Teaching surgical skills—changes in the wind.N Engl J Med.2006;355:26642669.
  10. Santen SA,Hemphill RR,McDonald MF,Jo CO.Patients' willingness to allow residents to learn to practice medical procedures.Acad Med.2004;79:144147.
  11. Fitts PM,Posner MI.Human performance.Belmont, CA:Brooks/Cole;1967.
  12. Barsuk J,McGaghie W,Cohen E,Balachandran J,Wayne D.Use of simulation‐based mastery learning to improve the quality of central venous catheter placement in a medical intensive care unit.J Hosp Med.2009;4(7):397403.
  13. Rosen BT,Uddin PQ,Harrington AR,Ault BW,Ault MJ.Does personalized vascular access training on a non‐human tissue model allow for learning and retention of central line placement skills? Phase II of the procedural patient safety initiative (PPSI‐II).J Hosp Med.2009;4(7):423429.
  14. Millington S,Wong R,Kassen B,Roberts J,Ma I.Improving internal medicine residents' performance, knowledge, and confidence in central venous catheterization using simulators.J Hosp Med.2009;4(7):410414.
  15. Ericsson KA,Charness N,Feltovich PJ,Hoffman RR.The Cambridge handbook of expertise and expert performance.New York, NY:Cambridge University Press;2006.
  16. Wayne DB,Barsuk JH,McGaghie WC.Procedural training at a crossroads: striking a balance between education, patient safety, and quality.J Hosp Med.2007;2:123125.
  17. Grober ED,Hamstra SJ,Wanzel KR, et al.The educational impact of bench model fidelity on the acquisition of technical skill: the use of clinically relevant outcome measures.Ann Surg.2004;240:374381.
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Internal medicine residency programs, the major pipeline for incoming hospitalists, often provide little hands‐on experience in bedside procedures. Some residents may only insert 1 central venous catheter every 4 months on the general medicine wards,1 and others may gain little more experience during intensive care unit rotations. As seen in the survey presented by Grover et al.2 in this issue of the Journal, after 3 years of training in all types of patient care units, residents often count their accumulated experience on their fingers and toes. Such sparse experience hardly leads to expertise. Recognizing this pervasive lack of training the American Board of Internal Medicine narrowed its certification requirements for bedside procedures in 2006.3 Residents are no longer expected to perform bedside procedures but instead to know them. This important revision acknowledges that manual skills training should neither be assumed nor expendablecontinuing to do so is too risky.4 Yet as internal medicine residency programs focus their bedside procedure training on cognitive competence, the ongoing exodus of bedside procedures to the up‐market hands of subspecialists, surgeons, anesthesiologists, and interventional radiologists5 will likely accelerate.

But why should hospitalists disrupt this trend? Bedside procedures are common and not always conveniently needed during daytime hours. Roughly one‐tenth of general medicine inpatients receive a central venous catheter (CVC) insertion, a lumbar puncture, an abdominal paracentesis, or a thoracentesis.6 Among these patients, about one‐half will urgently need procedures during off‐hours. Outside of the emergency department, hospitalists will likely remain the only group of physicians available at the bedsides of general medicine inpatients 7 days a week, 24 hours per day. Thus, in developing our particular practice system to best serve our patients,7 we believe that hospitalists ought to remain principals in ensuring that inpatients have ready access to expertly performed bedside procedures.

Yet unfortunately, given the limited training in manual skills that today's internal medicine residents receive, hospitalists are increasingly less prepared to provide this access themselves.8 State‐of‐the‐art training methods developed by medical specialties that depend largely on manual skills provide promising potential solutions for both future and practicing hospitalists.9 In particular, patient simulators can provide trainees with the essential hands‐on experience they often lack. In contrast to the ad hoc see‐one, do‐one, teach‐one method in current widespread use, training with simulators has distinct advantages. First, simulators obviate the increasingly awkward consent as patients grow savvier about safety concerns and (understandably) less tolerant of a novice's need to acquire experience.10 Second, training with simulators is controlled so that anatomic variations, comorbidities, patient discomfort, and time pressuresthough important real‐world factorscan be artificially removed in the earlier cognitive and integrative stages of training.11 Third, immediate feedback, which at the bedside of real patients is often empathetically avoided or delivered in cryptic hand signals, can be unmistakably unmuted and honest in the simulator setting. Fourth, and most important to the development of expertise, simulators can be used repeatedly, allowing trainees first to become facile in the mechanics of their performance (eg, holding an ultrasound probe for real‐time guidance or knowing how it feels to enter a vein) before attempting a procedure on a patient.

Three examples of patient simulators used to train internal medicine residents in CVC insertion are presented in this issue of the Journal.1214 Using observers who adhered to objective, a priori assessment criteria, both Rosen et al.13 and Millington et al.14 carefully demonstrate that internal medicine residents' manual skills can improve with patient simulators. Given the understood importance of hands‐on experience in manual skills training,15 these anticipated findings are important validations of simulator theory. The work by Barsuk et al.12 goes further to begin to examine whether or not simulator training actually leads to improved patient outcomesthe holy grail of such research. In this observational study, compared to residents who did not undergo simulator training, those who did undergo such training had 1 fewer needle passes during successful CVC insertions. Given the relative infrequency of periprocedural complications, this study was understandably underpowered to measure true complications, relying instead on the often‐used surrogate of needle passes. Nonetheless, this work will serve as an important initial example of why simulator training may be worth the effort.

To direct participation in simulator training, we endorse selecting trainees who will perform bedside procedures in their future practice.16 Given the trend in manual skills training among internal medicine residency training programs, hospitalist programs may need to shoulder this effort themselves. Thankfully, simulator training need not be expensive. Based on transfer‐of‐learning research,17 the fidelity of the simulator is less important than the accumulated experience it can afford. Even low‐fidelity simulators, such as the store‐bought whole chicken used by Rosen et al.,13 may preserve trainees' manual skills just as effectively as the expensive, bionic, high‐fidelity simulators used by Barsuk et al.12 and Millington et al.14

Beyond the costs of training, however, hospital administrators and hospitalist group leaders have more complex externalities and opportunity costs to weigh when evaluating which physician groups should perform bedside procedures. The intuitively lower‐cost strategy for hospitals, we believe, would be to ask hospitalists to perform bedside procedures at patients' bedsides instead of asking, say, highly‐paid interventional radiologists to perform the same procedures in fully‐staffed fluoroscopy suites. There is, however, very little research to help inform these decisions. As hospitalists, we know firsthand that modern healthcare remuneration is based more on doing than on knowing. Yet, whether or not bedside procedures afford financial incentives for hospitalists is unclearmuch will depend on local factors. Regardless of the finances, we believe that hospitalists skilled in performing common bedside procedures can improve the quality and efficiency of care delivery at patients' bedsides. So, instead of a call to arms for yet another turf battle, let's continue development of state‐of‐the‐art training methods like simulators to ensure that future hospitalists can expertly perform bedside procedures. After all, fighting for improvements in patient safety is a battle that we hospitalists know how to win.

Internal medicine residency programs, the major pipeline for incoming hospitalists, often provide little hands‐on experience in bedside procedures. Some residents may only insert 1 central venous catheter every 4 months on the general medicine wards,1 and others may gain little more experience during intensive care unit rotations. As seen in the survey presented by Grover et al.2 in this issue of the Journal, after 3 years of training in all types of patient care units, residents often count their accumulated experience on their fingers and toes. Such sparse experience hardly leads to expertise. Recognizing this pervasive lack of training the American Board of Internal Medicine narrowed its certification requirements for bedside procedures in 2006.3 Residents are no longer expected to perform bedside procedures but instead to know them. This important revision acknowledges that manual skills training should neither be assumed nor expendablecontinuing to do so is too risky.4 Yet as internal medicine residency programs focus their bedside procedure training on cognitive competence, the ongoing exodus of bedside procedures to the up‐market hands of subspecialists, surgeons, anesthesiologists, and interventional radiologists5 will likely accelerate.

But why should hospitalists disrupt this trend? Bedside procedures are common and not always conveniently needed during daytime hours. Roughly one‐tenth of general medicine inpatients receive a central venous catheter (CVC) insertion, a lumbar puncture, an abdominal paracentesis, or a thoracentesis.6 Among these patients, about one‐half will urgently need procedures during off‐hours. Outside of the emergency department, hospitalists will likely remain the only group of physicians available at the bedsides of general medicine inpatients 7 days a week, 24 hours per day. Thus, in developing our particular practice system to best serve our patients,7 we believe that hospitalists ought to remain principals in ensuring that inpatients have ready access to expertly performed bedside procedures.

Yet unfortunately, given the limited training in manual skills that today's internal medicine residents receive, hospitalists are increasingly less prepared to provide this access themselves.8 State‐of‐the‐art training methods developed by medical specialties that depend largely on manual skills provide promising potential solutions for both future and practicing hospitalists.9 In particular, patient simulators can provide trainees with the essential hands‐on experience they often lack. In contrast to the ad hoc see‐one, do‐one, teach‐one method in current widespread use, training with simulators has distinct advantages. First, simulators obviate the increasingly awkward consent as patients grow savvier about safety concerns and (understandably) less tolerant of a novice's need to acquire experience.10 Second, training with simulators is controlled so that anatomic variations, comorbidities, patient discomfort, and time pressuresthough important real‐world factorscan be artificially removed in the earlier cognitive and integrative stages of training.11 Third, immediate feedback, which at the bedside of real patients is often empathetically avoided or delivered in cryptic hand signals, can be unmistakably unmuted and honest in the simulator setting. Fourth, and most important to the development of expertise, simulators can be used repeatedly, allowing trainees first to become facile in the mechanics of their performance (eg, holding an ultrasound probe for real‐time guidance or knowing how it feels to enter a vein) before attempting a procedure on a patient.

Three examples of patient simulators used to train internal medicine residents in CVC insertion are presented in this issue of the Journal.1214 Using observers who adhered to objective, a priori assessment criteria, both Rosen et al.13 and Millington et al.14 carefully demonstrate that internal medicine residents' manual skills can improve with patient simulators. Given the understood importance of hands‐on experience in manual skills training,15 these anticipated findings are important validations of simulator theory. The work by Barsuk et al.12 goes further to begin to examine whether or not simulator training actually leads to improved patient outcomesthe holy grail of such research. In this observational study, compared to residents who did not undergo simulator training, those who did undergo such training had 1 fewer needle passes during successful CVC insertions. Given the relative infrequency of periprocedural complications, this study was understandably underpowered to measure true complications, relying instead on the often‐used surrogate of needle passes. Nonetheless, this work will serve as an important initial example of why simulator training may be worth the effort.

To direct participation in simulator training, we endorse selecting trainees who will perform bedside procedures in their future practice.16 Given the trend in manual skills training among internal medicine residency training programs, hospitalist programs may need to shoulder this effort themselves. Thankfully, simulator training need not be expensive. Based on transfer‐of‐learning research,17 the fidelity of the simulator is less important than the accumulated experience it can afford. Even low‐fidelity simulators, such as the store‐bought whole chicken used by Rosen et al.,13 may preserve trainees' manual skills just as effectively as the expensive, bionic, high‐fidelity simulators used by Barsuk et al.12 and Millington et al.14

Beyond the costs of training, however, hospital administrators and hospitalist group leaders have more complex externalities and opportunity costs to weigh when evaluating which physician groups should perform bedside procedures. The intuitively lower‐cost strategy for hospitals, we believe, would be to ask hospitalists to perform bedside procedures at patients' bedsides instead of asking, say, highly‐paid interventional radiologists to perform the same procedures in fully‐staffed fluoroscopy suites. There is, however, very little research to help inform these decisions. As hospitalists, we know firsthand that modern healthcare remuneration is based more on doing than on knowing. Yet, whether or not bedside procedures afford financial incentives for hospitalists is unclearmuch will depend on local factors. Regardless of the finances, we believe that hospitalists skilled in performing common bedside procedures can improve the quality and efficiency of care delivery at patients' bedsides. So, instead of a call to arms for yet another turf battle, let's continue development of state‐of‐the‐art training methods like simulators to ensure that future hospitalists can expertly perform bedside procedures. After all, fighting for improvements in patient safety is a battle that we hospitalists know how to win.

References
  1. Miranda JA,Trick WE,Evans AT,Charles‐Damte M,Reilly BM,Clarke P.Firm‐based trial to improve central venous catheter insertion practices.J Hosp Med.2007;2:135142.
  2. Grover S,Currier P,Elinoff J,Mouchantaf K,Katz J,McMahon G.Development of a test to evaluate residents' knowledge of medical procedures.J Hosp Med.2009;XX:XXXXXX.
  3. American Board of Internal Medicine. Policies and procedures for certification, May 2009. Available at: http://www.abim.org/default.aspx; Accessed August2009.
  4. Fincher RM.Procedural competence of internal medicine residents: time to address the gap.J Gen Intern Med.2000;15:432433.
  5. Wigton RS,Alguire P.The declining number and variety of procedures done by general internists: a resurvey of members of the American College of Physicians.Ann Intern Med.2007;146:355360.
  6. Lucas BP,Asbury JK,Wang Y, et al.Impact of a bedside procedure service on general medicine inpatients: a firm‐based trial.J Hosp Med.2006;2:143149.
  7. Duffy FD,Holmboe ES.What procedures should internists do?Ann Intern Med.2007;146:392394.
  8. Huang GC,Smith CC,Gordon CE, et al.Beyond the comfort zone: residents assess their comfort performing inpatient medical procedures.Am J Med.2006;119:71.e17e24
  9. Reznick RK,MacRae H.Teaching surgical skills—changes in the wind.N Engl J Med.2006;355:26642669.
  10. Santen SA,Hemphill RR,McDonald MF,Jo CO.Patients' willingness to allow residents to learn to practice medical procedures.Acad Med.2004;79:144147.
  11. Fitts PM,Posner MI.Human performance.Belmont, CA:Brooks/Cole;1967.
  12. Barsuk J,McGaghie W,Cohen E,Balachandran J,Wayne D.Use of simulation‐based mastery learning to improve the quality of central venous catheter placement in a medical intensive care unit.J Hosp Med.2009;4(7):397403.
  13. Rosen BT,Uddin PQ,Harrington AR,Ault BW,Ault MJ.Does personalized vascular access training on a non‐human tissue model allow for learning and retention of central line placement skills? Phase II of the procedural patient safety initiative (PPSI‐II).J Hosp Med.2009;4(7):423429.
  14. Millington S,Wong R,Kassen B,Roberts J,Ma I.Improving internal medicine residents' performance, knowledge, and confidence in central venous catheterization using simulators.J Hosp Med.2009;4(7):410414.
  15. Ericsson KA,Charness N,Feltovich PJ,Hoffman RR.The Cambridge handbook of expertise and expert performance.New York, NY:Cambridge University Press;2006.
  16. Wayne DB,Barsuk JH,McGaghie WC.Procedural training at a crossroads: striking a balance between education, patient safety, and quality.J Hosp Med.2007;2:123125.
  17. Grober ED,Hamstra SJ,Wanzel KR, et al.The educational impact of bench model fidelity on the acquisition of technical skill: the use of clinically relevant outcome measures.Ann Surg.2004;240:374381.
References
  1. Miranda JA,Trick WE,Evans AT,Charles‐Damte M,Reilly BM,Clarke P.Firm‐based trial to improve central venous catheter insertion practices.J Hosp Med.2007;2:135142.
  2. Grover S,Currier P,Elinoff J,Mouchantaf K,Katz J,McMahon G.Development of a test to evaluate residents' knowledge of medical procedures.J Hosp Med.2009;XX:XXXXXX.
  3. American Board of Internal Medicine. Policies and procedures for certification, May 2009. Available at: http://www.abim.org/default.aspx; Accessed August2009.
  4. Fincher RM.Procedural competence of internal medicine residents: time to address the gap.J Gen Intern Med.2000;15:432433.
  5. Wigton RS,Alguire P.The declining number and variety of procedures done by general internists: a resurvey of members of the American College of Physicians.Ann Intern Med.2007;146:355360.
  6. Lucas BP,Asbury JK,Wang Y, et al.Impact of a bedside procedure service on general medicine inpatients: a firm‐based trial.J Hosp Med.2006;2:143149.
  7. Duffy FD,Holmboe ES.What procedures should internists do?Ann Intern Med.2007;146:392394.
  8. Huang GC,Smith CC,Gordon CE, et al.Beyond the comfort zone: residents assess their comfort performing inpatient medical procedures.Am J Med.2006;119:71.e17e24
  9. Reznick RK,MacRae H.Teaching surgical skills—changes in the wind.N Engl J Med.2006;355:26642669.
  10. Santen SA,Hemphill RR,McDonald MF,Jo CO.Patients' willingness to allow residents to learn to practice medical procedures.Acad Med.2004;79:144147.
  11. Fitts PM,Posner MI.Human performance.Belmont, CA:Brooks/Cole;1967.
  12. Barsuk J,McGaghie W,Cohen E,Balachandran J,Wayne D.Use of simulation‐based mastery learning to improve the quality of central venous catheter placement in a medical intensive care unit.J Hosp Med.2009;4(7):397403.
  13. Rosen BT,Uddin PQ,Harrington AR,Ault BW,Ault MJ.Does personalized vascular access training on a non‐human tissue model allow for learning and retention of central line placement skills? Phase II of the procedural patient safety initiative (PPSI‐II).J Hosp Med.2009;4(7):423429.
  14. Millington S,Wong R,Kassen B,Roberts J,Ma I.Improving internal medicine residents' performance, knowledge, and confidence in central venous catheterization using simulators.J Hosp Med.2009;4(7):410414.
  15. Ericsson KA,Charness N,Feltovich PJ,Hoffman RR.The Cambridge handbook of expertise and expert performance.New York, NY:Cambridge University Press;2006.
  16. Wayne DB,Barsuk JH,McGaghie WC.Procedural training at a crossroads: striking a balance between education, patient safety, and quality.J Hosp Med.2007;2:123125.
  17. Grober ED,Hamstra SJ,Wanzel KR, et al.The educational impact of bench model fidelity on the acquisition of technical skill: the use of clinically relevant outcome measures.Ann Surg.2004;240:374381.
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Training future hospitalists with simulators: A needed step toward accessible, expertly performed bedside procedures
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Should catheter ablation be the first line of treatment for atrial fibrillation?

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Should catheter ablation be the first line of treatment for atrial fibrillation?

Catheter ablation for atrial fibrillation has evolved since it was introduced a decade ago. It will continue to improve as we gain experience with the procedure, better understand the pathophysiology of atrial fibrillation, and develop new technologies for imaging, catheter navigation, and more effective ablation of atrial tissue. The topic is reviewed by Chowdhury et al1 in this issue of the Cleveland Clinic Journal of Medicine.

See related article

An important question is whether catheter ablation should replace antiarrhythmic drugs as the first line of therapy. The answer will be determined by the procedure’s success rate, complication rate, cost, and long-term outcomes compared with drug therapy.

RELATIVELY FEW RANDOMIZED TRIALS, BUT ENCOURAGING RESULTS

Relatively few randomized trials have compared catheter ablation and medical therapy.

In patients with paroxysmal atrial fibrillation, three important randomized trials2–4 have shown catheter ablation to be superior to antiarrhythmic drug therapy. In these trials, freedom from atrial fibrillation or atrial flutter was achieved in 63% to 93% of patients who underwent ablation compared with 17% to 35% of those assigned to drug therapy. However, more than one ablation procedure may be required to achieve success rates in the higher range. Further, these studies were done at “high-volume” centers, and they excluded patients with major comorbidities.

Persistent or long-standing atrial fibrillation is more complex than paroxysmal atrial fibrillation. It is more often accompanied by significant comorbidities, and comparative trials have generally excluded patients with these attributes. Fewer of such patients obtain complete success (ie, cure), and more of them need a second ablation procedure.

Oral et al5 randomly assigned patients with long-standing atrial fibrillation to be treated with amiodarone (Cordarone) or catheter ablation. The analysis of this study was complicated by a high rate of crossover from the drug therapy group to the ablation group. Twenty-five (32%) of the 77 patients assigned to undergo ablation needed a second procedure, but at 12 months 74% were in sinus rhythm without amiodarone, compared with only 4% treated with amiodarone without ablation.

These results indicate that ablation is more effective than medical therapy for paroxysmal atrial fibrillation, and it appears to be more effective than drugs alone for long-standing persistent atrial fibrillation. In addition, quality of life was better after ablation, and complications were relatively few.2–4

The limitations are that the trials were done at hospitals in which the ablation teams had a lot of experience, did many ablation procedures per year, and tracked their outcomes carefully: other hospitals may not be able to achieve the same results. Moreover, many patients referred for ablation have heart failure, significant valvular disease, or left atrial enlargement, which would have excluded them from the published trials.

 

 

MORE STUDIES UNDER WAY

Two other initiatives may help define the role of ablation for atrial fibrillation.

The Cardiac Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (the CABANA) trial is a multicenter randomized longitudinal study designed to determine whether ablation is more effective than drug therapy. Target enrollment is 3,000 patients.

The National Cardiovascular Data Registry is exploring the possibility of establishing a registry for ablation of atrial fibrillation. This database could be used by physicians, hospitals, the Centers for Medicare & Medicaid Services, and the US Food and Drug Administration to track overall outcomes of these complex procedures.

FOR NOW, DRUGS ARE STILL THE FIRST-LINE TREATMENT

For now, I believe that antiarrhythmic drugs should remain the first line of treatment for atrial fibrillation until cumulative evidence from additional randomized multicenter trials proves otherwise. However, the threshold for deciding to do an ablation procedure is getting lower, and it is reasonable for patients to make an informed decision to move directly to ablation as an alternative to drug therapy if that is their preference.

To make these decisions, patients need accurate information about success rates and the risk of complications at the center where the procedure is to be performed. At Cleveland Clinic, where more than 4,300 ablation procedures have been performed for atrial fibrillation, substantial resources are devoted to tracking outcomes. As the government and insurance companies focus on pay for performance and as ablation procedures for atrial fibrillation become more widespread and new technologies are introduced, it will be especially important for hospitals to track their own costs and outcomes.

The cumulative experience from well-designed clinical trials will provide guidance, but unless hospitals verify that they achieve results equivalent to those in the trials, physicians should be cautious about recommending ablation as the first-line therapy.

References
  1. Chowdhury P, Lewis R, Schweikert R, Cummings JE. Catheter ablation for the treatment of atrial fibrillation. Cleve Clin J Med 2009; 76:543550.
  2. Pappone C, Augello G, Sala S, et al. A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation. the APAF Study. J Am Coll Cardiol 2006; 48:23402347.
  3. Jais P, Cauchemez , Macle L, et al. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 Study. Circulation 2008; 118:24982505.
  4. Wilber DJ, Pappone C, Neuzil P, et al; The Thermocool AF Investigators. Recurrent atrial arrhythmias and quality-of-life in patients with paroxysmal atrial fibrillation treated by radiofrequency catheter ablation compared to antiarrhythmic drug therapy: final results of the Thermocool AF trial. Presented at the Heart Rhythm Society Annual Scientific Sessions, May 13–19 2009, Boston, MA.
  5. Oral H, Pappone C, Chugh A, et al. Circumferential pulmonary-vein ablation for chronic atrial fibrillation. N Engl J Med 2006; 354:934941.
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Related Articles

Catheter ablation for atrial fibrillation has evolved since it was introduced a decade ago. It will continue to improve as we gain experience with the procedure, better understand the pathophysiology of atrial fibrillation, and develop new technologies for imaging, catheter navigation, and more effective ablation of atrial tissue. The topic is reviewed by Chowdhury et al1 in this issue of the Cleveland Clinic Journal of Medicine.

See related article

An important question is whether catheter ablation should replace antiarrhythmic drugs as the first line of therapy. The answer will be determined by the procedure’s success rate, complication rate, cost, and long-term outcomes compared with drug therapy.

RELATIVELY FEW RANDOMIZED TRIALS, BUT ENCOURAGING RESULTS

Relatively few randomized trials have compared catheter ablation and medical therapy.

In patients with paroxysmal atrial fibrillation, three important randomized trials2–4 have shown catheter ablation to be superior to antiarrhythmic drug therapy. In these trials, freedom from atrial fibrillation or atrial flutter was achieved in 63% to 93% of patients who underwent ablation compared with 17% to 35% of those assigned to drug therapy. However, more than one ablation procedure may be required to achieve success rates in the higher range. Further, these studies were done at “high-volume” centers, and they excluded patients with major comorbidities.

Persistent or long-standing atrial fibrillation is more complex than paroxysmal atrial fibrillation. It is more often accompanied by significant comorbidities, and comparative trials have generally excluded patients with these attributes. Fewer of such patients obtain complete success (ie, cure), and more of them need a second ablation procedure.

Oral et al5 randomly assigned patients with long-standing atrial fibrillation to be treated with amiodarone (Cordarone) or catheter ablation. The analysis of this study was complicated by a high rate of crossover from the drug therapy group to the ablation group. Twenty-five (32%) of the 77 patients assigned to undergo ablation needed a second procedure, but at 12 months 74% were in sinus rhythm without amiodarone, compared with only 4% treated with amiodarone without ablation.

These results indicate that ablation is more effective than medical therapy for paroxysmal atrial fibrillation, and it appears to be more effective than drugs alone for long-standing persistent atrial fibrillation. In addition, quality of life was better after ablation, and complications were relatively few.2–4

The limitations are that the trials were done at hospitals in which the ablation teams had a lot of experience, did many ablation procedures per year, and tracked their outcomes carefully: other hospitals may not be able to achieve the same results. Moreover, many patients referred for ablation have heart failure, significant valvular disease, or left atrial enlargement, which would have excluded them from the published trials.

 

 

MORE STUDIES UNDER WAY

Two other initiatives may help define the role of ablation for atrial fibrillation.

The Cardiac Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (the CABANA) trial is a multicenter randomized longitudinal study designed to determine whether ablation is more effective than drug therapy. Target enrollment is 3,000 patients.

The National Cardiovascular Data Registry is exploring the possibility of establishing a registry for ablation of atrial fibrillation. This database could be used by physicians, hospitals, the Centers for Medicare & Medicaid Services, and the US Food and Drug Administration to track overall outcomes of these complex procedures.

FOR NOW, DRUGS ARE STILL THE FIRST-LINE TREATMENT

For now, I believe that antiarrhythmic drugs should remain the first line of treatment for atrial fibrillation until cumulative evidence from additional randomized multicenter trials proves otherwise. However, the threshold for deciding to do an ablation procedure is getting lower, and it is reasonable for patients to make an informed decision to move directly to ablation as an alternative to drug therapy if that is their preference.

To make these decisions, patients need accurate information about success rates and the risk of complications at the center where the procedure is to be performed. At Cleveland Clinic, where more than 4,300 ablation procedures have been performed for atrial fibrillation, substantial resources are devoted to tracking outcomes. As the government and insurance companies focus on pay for performance and as ablation procedures for atrial fibrillation become more widespread and new technologies are introduced, it will be especially important for hospitals to track their own costs and outcomes.

The cumulative experience from well-designed clinical trials will provide guidance, but unless hospitals verify that they achieve results equivalent to those in the trials, physicians should be cautious about recommending ablation as the first-line therapy.

Catheter ablation for atrial fibrillation has evolved since it was introduced a decade ago. It will continue to improve as we gain experience with the procedure, better understand the pathophysiology of atrial fibrillation, and develop new technologies for imaging, catheter navigation, and more effective ablation of atrial tissue. The topic is reviewed by Chowdhury et al1 in this issue of the Cleveland Clinic Journal of Medicine.

See related article

An important question is whether catheter ablation should replace antiarrhythmic drugs as the first line of therapy. The answer will be determined by the procedure’s success rate, complication rate, cost, and long-term outcomes compared with drug therapy.

RELATIVELY FEW RANDOMIZED TRIALS, BUT ENCOURAGING RESULTS

Relatively few randomized trials have compared catheter ablation and medical therapy.

In patients with paroxysmal atrial fibrillation, three important randomized trials2–4 have shown catheter ablation to be superior to antiarrhythmic drug therapy. In these trials, freedom from atrial fibrillation or atrial flutter was achieved in 63% to 93% of patients who underwent ablation compared with 17% to 35% of those assigned to drug therapy. However, more than one ablation procedure may be required to achieve success rates in the higher range. Further, these studies were done at “high-volume” centers, and they excluded patients with major comorbidities.

Persistent or long-standing atrial fibrillation is more complex than paroxysmal atrial fibrillation. It is more often accompanied by significant comorbidities, and comparative trials have generally excluded patients with these attributes. Fewer of such patients obtain complete success (ie, cure), and more of them need a second ablation procedure.

Oral et al5 randomly assigned patients with long-standing atrial fibrillation to be treated with amiodarone (Cordarone) or catheter ablation. The analysis of this study was complicated by a high rate of crossover from the drug therapy group to the ablation group. Twenty-five (32%) of the 77 patients assigned to undergo ablation needed a second procedure, but at 12 months 74% were in sinus rhythm without amiodarone, compared with only 4% treated with amiodarone without ablation.

These results indicate that ablation is more effective than medical therapy for paroxysmal atrial fibrillation, and it appears to be more effective than drugs alone for long-standing persistent atrial fibrillation. In addition, quality of life was better after ablation, and complications were relatively few.2–4

The limitations are that the trials were done at hospitals in which the ablation teams had a lot of experience, did many ablation procedures per year, and tracked their outcomes carefully: other hospitals may not be able to achieve the same results. Moreover, many patients referred for ablation have heart failure, significant valvular disease, or left atrial enlargement, which would have excluded them from the published trials.

 

 

MORE STUDIES UNDER WAY

Two other initiatives may help define the role of ablation for atrial fibrillation.

The Cardiac Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (the CABANA) trial is a multicenter randomized longitudinal study designed to determine whether ablation is more effective than drug therapy. Target enrollment is 3,000 patients.

The National Cardiovascular Data Registry is exploring the possibility of establishing a registry for ablation of atrial fibrillation. This database could be used by physicians, hospitals, the Centers for Medicare & Medicaid Services, and the US Food and Drug Administration to track overall outcomes of these complex procedures.

FOR NOW, DRUGS ARE STILL THE FIRST-LINE TREATMENT

For now, I believe that antiarrhythmic drugs should remain the first line of treatment for atrial fibrillation until cumulative evidence from additional randomized multicenter trials proves otherwise. However, the threshold for deciding to do an ablation procedure is getting lower, and it is reasonable for patients to make an informed decision to move directly to ablation as an alternative to drug therapy if that is their preference.

To make these decisions, patients need accurate information about success rates and the risk of complications at the center where the procedure is to be performed. At Cleveland Clinic, where more than 4,300 ablation procedures have been performed for atrial fibrillation, substantial resources are devoted to tracking outcomes. As the government and insurance companies focus on pay for performance and as ablation procedures for atrial fibrillation become more widespread and new technologies are introduced, it will be especially important for hospitals to track their own costs and outcomes.

The cumulative experience from well-designed clinical trials will provide guidance, but unless hospitals verify that they achieve results equivalent to those in the trials, physicians should be cautious about recommending ablation as the first-line therapy.

References
  1. Chowdhury P, Lewis R, Schweikert R, Cummings JE. Catheter ablation for the treatment of atrial fibrillation. Cleve Clin J Med 2009; 76:543550.
  2. Pappone C, Augello G, Sala S, et al. A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation. the APAF Study. J Am Coll Cardiol 2006; 48:23402347.
  3. Jais P, Cauchemez , Macle L, et al. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 Study. Circulation 2008; 118:24982505.
  4. Wilber DJ, Pappone C, Neuzil P, et al; The Thermocool AF Investigators. Recurrent atrial arrhythmias and quality-of-life in patients with paroxysmal atrial fibrillation treated by radiofrequency catheter ablation compared to antiarrhythmic drug therapy: final results of the Thermocool AF trial. Presented at the Heart Rhythm Society Annual Scientific Sessions, May 13–19 2009, Boston, MA.
  5. Oral H, Pappone C, Chugh A, et al. Circumferential pulmonary-vein ablation for chronic atrial fibrillation. N Engl J Med 2006; 354:934941.
References
  1. Chowdhury P, Lewis R, Schweikert R, Cummings JE. Catheter ablation for the treatment of atrial fibrillation. Cleve Clin J Med 2009; 76:543550.
  2. Pappone C, Augello G, Sala S, et al. A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation. the APAF Study. J Am Coll Cardiol 2006; 48:23402347.
  3. Jais P, Cauchemez , Macle L, et al. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 Study. Circulation 2008; 118:24982505.
  4. Wilber DJ, Pappone C, Neuzil P, et al; The Thermocool AF Investigators. Recurrent atrial arrhythmias and quality-of-life in patients with paroxysmal atrial fibrillation treated by radiofrequency catheter ablation compared to antiarrhythmic drug therapy: final results of the Thermocool AF trial. Presented at the Heart Rhythm Society Annual Scientific Sessions, May 13–19 2009, Boston, MA.
  5. Oral H, Pappone C, Chugh A, et al. Circumferential pulmonary-vein ablation for chronic atrial fibrillation. N Engl J Med 2006; 354:934941.
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Safety in numbers: Physicians joining forces to seal the cracks during transitions

A lack of communication and accountability among healthcare professionals in general, and physicians in particular, jeopardizes quality and safety for our patients who are transitioning across sites of care.1, 2 Our patients, their family caregivers, and our health care professional colleagues on the receiving end of these transfers are often left flying blind without adequate information or direction to make sound clinical decisions.

Beyond our attempts to ensure effective transitions on a professional level, many of the readers of the Journal of Hospital Medicine likely have struggled to ensure seamless transitions for our families, despite the benefits of our training and experience.3 If some of the nation's most respected healthcare leaders are unable to make this work for their loved ones,48 one can only imagine the challenges faced by those without such advantages.

National and local quality collaboratives aimed at improving communication and collaboration across settings have found physicians difficult to engage as partners in these efforts.9 All too often there is a false expectation that these types of activities are best left to nonphysician healthcare professionals on the sending side of the transfer or to those receiving the transfer.10, 11

In this issue of the Journal, we commend the leadership provided by representatives of 6 of the nation's leading physician professional societies to join forces toward the common purpose of articulating physicians' roles and accountability for care delivered during transitions.12 Ensuring effective care transitions is a team sport, yet rarely do we have a clear understanding of who are the other members of our team, how to interact with them, or a clear delineation of their respective roles. Simply stated, this article is a key step to facilitating teamwork across settings among physicians, our interdisciplinary healthcare professional colleagues, our patients, and their family caregivers. These standards clearly convey the type of care we expect for our loved ones.

Drawing from proven strategies used in nonhealthcare industries, the standards assert that the sending provider or institution retains responsibility for the patient's care until the receiving team confirms receipt of the transfer and assumes responsibility. Further, the receiving team is given the opportunity to ask questions and clarify the proposed care plan in recognition of the fact that communication is more than simply the transfer of information. Rather, such communication involves the need to ensure comprehension and provide an opportunity to have a 2‐way dialog. These standards distinguish between the transmission of information and true communication.

The timing of the release of these standards is ideal. As physicians concentrate their practice within particular settings we can no longer rely on casual random interchanges in hospital parking lots or the hospital's physician lounge. Rather, we need to take a more active and reliable approach to ensuring timely and accurate exchanges. These standards cut to the essence of how we communicate with our physician and nonphysician colleagues alike, and in so doing move us away from nonproductive blame and finger‐pointing.

Although the implications for these standards are far reaching in terms of raising the quality bar, they could reach even further with respect to the types of settings they address. These standards need to extend beyond hospitals and the outpatient arena to include nursing homes, rehabilitation facilities, home care agencies, adult day health centers, and other settings where chronic care services are delivered.

Further, the standards devote considerable focus to the transfer of health information. Even with advances in health information exchange technologies, we must recognize that information is necessary but not sufficient for ensuring safe and high‐quality transfers. Implementing these standards will undoubtedly require that we reconfigure our daily workflows.13 The article in this issue by Graumlich et al.14 emphasizes the challenges of how to introduce technology into our daily clinical routines. The standards also open the door for how we can best ensure not just the transmission of information, but also the comprehension of transfer instructions to our patients with attention to health literacy, cognitive ability, and the patient's level of activation.15 Best and Young16 provide valuable action steps for how to address the needs of diverse and underserved populations.

These standards may serve to uncover the fact that most physicians have not received formal training in executing high‐quality care transitions in the role of either the sender or the receiver. Further, few physicians have a mechanism in place to evaluate their performance. The American Board of Internal Medicine and the American Board of Family Practice has developed Maintenance of Certification Practice Improvement Modules (PIM) on care coordination that provide an excellent opportunity to sharpen our skills. The HMO Care Management Workgroup has also attempted to summarize the essential skills necessary to care for patients during transitions.17

Perhaps the greatest value of these standards is that they lay the framework for actionable improvement. Local, state, and national quality collaboratives can immediately incorporate these recommendations into their overall strategy. These standards will likely influence the design and implementation of the Medical Home.18 As national attention focuses on how to operationalize bundled payment approaches and Accountable Care Organizations,19 these standards provide a clear consensus on communication, accountability, and ensuring patient‐centeredness. The standards are an excellent start and provide a framework for further innovation.

One area in particular may be the opportunity to reinvent the format, content, and medium by which essential information is transferred. For example, one might envision the value of producing a scaled down version of the discharge summary with a limited core set of data elements that could be quickly completed and communicated to the next care team via fax, e‐mail, or text messaging.

Complementing new strategies to improve the exchange of health information are opportunities to reconsider the culture within which this communication occurs. Our profession has a long‐standing tradition of not providing directives to our colleagues on the details of clinical management. Hospitalists develop important insights during a patient's hospital stay and are in an ideal position to anticipate potential developments in the subsequent course after discharge. Contrast this with the 5 to 10 minutes that a primary care physician or specialist may have to come up to speed on the hospital and posthospital events in order to manage the patient in the ambulatory arena. Thus, rather than the traditional historical orientation to a discharge summary, one could envision a more future‐orientated document characterized by a series of if‐then statements that outline a series of possible clinical scenarios that may play out over the weeks after discharge along with recommendations for adjustments to the treatment plan.

At a broader level, the release of these standards demonstrate to our communities and to our nation that physicians can join forces to address a particularly complex and challenging aspect of healthcare. Change can indeed come from within our profession rather than being imposed by outside influences such as government administrators, regulatory bodies, or malpractice attorneys. I applaud such efforts and believe that hospitalists will continue to play a central role in national efforts to improve transitions of care.

References
  1. Kripalani S,Phillips CO,Basaviah P,Williams MV,Saint SK,Baker DW.Deficits in information transfer from inpatient to outpatient physician at hospital discharge: a systematic review.J Gen Intern Med.2004;19(S1):135.
  2. Coleman EA,Berenson RA.Lost in transition: challenges and opportunities for improving the quality of transitional care.Ann Intern Med.2004;141(7):533536.
  3. Kane R,West J.It Shouldn't Be This Way: The Failure of Long Term Care.1st ed.Nashville, TN:Vanderbilt University Press;2005.
  4. Pham HH.Dismantling Rube Goldberg: cutting through chaos to achieve coordinated care.J Hosp Med.2009;4(4):259260.
  5. Levin PE,Levin EJ.The experience of an orthopaedic traumatologist when the trauma hits home: observations and suggestions.J Bone Joint Surg Am.2008;90(9):20262036.
  6. Berwick DM.Quality comes home.Ann Intern Med.1996;125(10):839843.
  7. Lawrence DM.My mother and the medical care ad‐hoc‐racy.Health Aff.2003;22(2):238242.
  8. Cleary P.A hospitalization from hell: a patient's perspective on quality.Ann Intern Med.2003;138:3339.
  9. Boyce PS,Pace KB,Lauder B,Solomon DA.The ReACH Collaborative—improving quality home care.Caring.2007;26(8):4451.
  10. Next step in care. Available at: http://www.nextstepincare.org. Accessed June2009.
  11. Bennett RE,Tuttle M,May K,Harvell J,Coleman EA. Health information exchange in post‐acute and long‐term care case study findings: final report. 2007. Office of Disability, Aging and Long‐Term Care Policy; Office of the Assistant Secretary for Planning and Evaluation; U.S. Department of Health and Human Services. Available at: http://aspe.hhs.gov/daltcp/reports/2007/HIEcase.pdf. Accessed June2009.
  12. Snow V.Transitions of Care Consensus Policy Statement. American College of Physicians‐Society of General Internal Medicine‐Society of Hospital Medicine‐American Geriatrics Society‐American College of Emergency Physicians‐Society of Academic Emergency Medicine.J Hosp Med.2009;4(6):364370.
  13. Chugh A,Williams MV,Grigsby J,Coleman E.Better transitions: improving comprehension of discharge instructions.Front Health Serv Manag.2009;25(3):1132.
  14. Graumlich J,Novotny N,Nace G,Aldag J.Patient and physician perceptions after software‐assisted discharge from hospital: cluster randomized trial.J Hosp Med.2009;4(6):356363.
  15. Patient Activation Measure. Available at: http://www.insigniahealth.com/products/pam.html. Accessed June2009.
  16. Best J,Young A.A SAFE DC: a conceptual framework for care of the homeless inpatient.J Hosp Med2009;4(6):375381.
  17. HMO Care Management Workgroup. One patient, many places: managing healthcare transitions. 2004. Available at: http://www.caretransitions. org/documents/One%20Patient%20RWJ%20Report.pdf. Accessed June2009.
  18. American College of Physicians. Patient‐Centered Medical Home: ACP delivers expanded PCMH resources online. Available at: http://www.acponline.org/advocacy/where_we_stand/medical_home. Accessed June2009.
  19. American College of Physicians. Accountable Care Organizations. Available at: http://www.acponline.org/advocacy/where_we_stand/medical_ home. Accessed June2009.
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A lack of communication and accountability among healthcare professionals in general, and physicians in particular, jeopardizes quality and safety for our patients who are transitioning across sites of care.1, 2 Our patients, their family caregivers, and our health care professional colleagues on the receiving end of these transfers are often left flying blind without adequate information or direction to make sound clinical decisions.

Beyond our attempts to ensure effective transitions on a professional level, many of the readers of the Journal of Hospital Medicine likely have struggled to ensure seamless transitions for our families, despite the benefits of our training and experience.3 If some of the nation's most respected healthcare leaders are unable to make this work for their loved ones,48 one can only imagine the challenges faced by those without such advantages.

National and local quality collaboratives aimed at improving communication and collaboration across settings have found physicians difficult to engage as partners in these efforts.9 All too often there is a false expectation that these types of activities are best left to nonphysician healthcare professionals on the sending side of the transfer or to those receiving the transfer.10, 11

In this issue of the Journal, we commend the leadership provided by representatives of 6 of the nation's leading physician professional societies to join forces toward the common purpose of articulating physicians' roles and accountability for care delivered during transitions.12 Ensuring effective care transitions is a team sport, yet rarely do we have a clear understanding of who are the other members of our team, how to interact with them, or a clear delineation of their respective roles. Simply stated, this article is a key step to facilitating teamwork across settings among physicians, our interdisciplinary healthcare professional colleagues, our patients, and their family caregivers. These standards clearly convey the type of care we expect for our loved ones.

Drawing from proven strategies used in nonhealthcare industries, the standards assert that the sending provider or institution retains responsibility for the patient's care until the receiving team confirms receipt of the transfer and assumes responsibility. Further, the receiving team is given the opportunity to ask questions and clarify the proposed care plan in recognition of the fact that communication is more than simply the transfer of information. Rather, such communication involves the need to ensure comprehension and provide an opportunity to have a 2‐way dialog. These standards distinguish between the transmission of information and true communication.

The timing of the release of these standards is ideal. As physicians concentrate their practice within particular settings we can no longer rely on casual random interchanges in hospital parking lots or the hospital's physician lounge. Rather, we need to take a more active and reliable approach to ensuring timely and accurate exchanges. These standards cut to the essence of how we communicate with our physician and nonphysician colleagues alike, and in so doing move us away from nonproductive blame and finger‐pointing.

Although the implications for these standards are far reaching in terms of raising the quality bar, they could reach even further with respect to the types of settings they address. These standards need to extend beyond hospitals and the outpatient arena to include nursing homes, rehabilitation facilities, home care agencies, adult day health centers, and other settings where chronic care services are delivered.

Further, the standards devote considerable focus to the transfer of health information. Even with advances in health information exchange technologies, we must recognize that information is necessary but not sufficient for ensuring safe and high‐quality transfers. Implementing these standards will undoubtedly require that we reconfigure our daily workflows.13 The article in this issue by Graumlich et al.14 emphasizes the challenges of how to introduce technology into our daily clinical routines. The standards also open the door for how we can best ensure not just the transmission of information, but also the comprehension of transfer instructions to our patients with attention to health literacy, cognitive ability, and the patient's level of activation.15 Best and Young16 provide valuable action steps for how to address the needs of diverse and underserved populations.

These standards may serve to uncover the fact that most physicians have not received formal training in executing high‐quality care transitions in the role of either the sender or the receiver. Further, few physicians have a mechanism in place to evaluate their performance. The American Board of Internal Medicine and the American Board of Family Practice has developed Maintenance of Certification Practice Improvement Modules (PIM) on care coordination that provide an excellent opportunity to sharpen our skills. The HMO Care Management Workgroup has also attempted to summarize the essential skills necessary to care for patients during transitions.17

Perhaps the greatest value of these standards is that they lay the framework for actionable improvement. Local, state, and national quality collaboratives can immediately incorporate these recommendations into their overall strategy. These standards will likely influence the design and implementation of the Medical Home.18 As national attention focuses on how to operationalize bundled payment approaches and Accountable Care Organizations,19 these standards provide a clear consensus on communication, accountability, and ensuring patient‐centeredness. The standards are an excellent start and provide a framework for further innovation.

One area in particular may be the opportunity to reinvent the format, content, and medium by which essential information is transferred. For example, one might envision the value of producing a scaled down version of the discharge summary with a limited core set of data elements that could be quickly completed and communicated to the next care team via fax, e‐mail, or text messaging.

Complementing new strategies to improve the exchange of health information are opportunities to reconsider the culture within which this communication occurs. Our profession has a long‐standing tradition of not providing directives to our colleagues on the details of clinical management. Hospitalists develop important insights during a patient's hospital stay and are in an ideal position to anticipate potential developments in the subsequent course after discharge. Contrast this with the 5 to 10 minutes that a primary care physician or specialist may have to come up to speed on the hospital and posthospital events in order to manage the patient in the ambulatory arena. Thus, rather than the traditional historical orientation to a discharge summary, one could envision a more future‐orientated document characterized by a series of if‐then statements that outline a series of possible clinical scenarios that may play out over the weeks after discharge along with recommendations for adjustments to the treatment plan.

At a broader level, the release of these standards demonstrate to our communities and to our nation that physicians can join forces to address a particularly complex and challenging aspect of healthcare. Change can indeed come from within our profession rather than being imposed by outside influences such as government administrators, regulatory bodies, or malpractice attorneys. I applaud such efforts and believe that hospitalists will continue to play a central role in national efforts to improve transitions of care.

A lack of communication and accountability among healthcare professionals in general, and physicians in particular, jeopardizes quality and safety for our patients who are transitioning across sites of care.1, 2 Our patients, their family caregivers, and our health care professional colleagues on the receiving end of these transfers are often left flying blind without adequate information or direction to make sound clinical decisions.

Beyond our attempts to ensure effective transitions on a professional level, many of the readers of the Journal of Hospital Medicine likely have struggled to ensure seamless transitions for our families, despite the benefits of our training and experience.3 If some of the nation's most respected healthcare leaders are unable to make this work for their loved ones,48 one can only imagine the challenges faced by those without such advantages.

National and local quality collaboratives aimed at improving communication and collaboration across settings have found physicians difficult to engage as partners in these efforts.9 All too often there is a false expectation that these types of activities are best left to nonphysician healthcare professionals on the sending side of the transfer or to those receiving the transfer.10, 11

In this issue of the Journal, we commend the leadership provided by representatives of 6 of the nation's leading physician professional societies to join forces toward the common purpose of articulating physicians' roles and accountability for care delivered during transitions.12 Ensuring effective care transitions is a team sport, yet rarely do we have a clear understanding of who are the other members of our team, how to interact with them, or a clear delineation of their respective roles. Simply stated, this article is a key step to facilitating teamwork across settings among physicians, our interdisciplinary healthcare professional colleagues, our patients, and their family caregivers. These standards clearly convey the type of care we expect for our loved ones.

Drawing from proven strategies used in nonhealthcare industries, the standards assert that the sending provider or institution retains responsibility for the patient's care until the receiving team confirms receipt of the transfer and assumes responsibility. Further, the receiving team is given the opportunity to ask questions and clarify the proposed care plan in recognition of the fact that communication is more than simply the transfer of information. Rather, such communication involves the need to ensure comprehension and provide an opportunity to have a 2‐way dialog. These standards distinguish between the transmission of information and true communication.

The timing of the release of these standards is ideal. As physicians concentrate their practice within particular settings we can no longer rely on casual random interchanges in hospital parking lots or the hospital's physician lounge. Rather, we need to take a more active and reliable approach to ensuring timely and accurate exchanges. These standards cut to the essence of how we communicate with our physician and nonphysician colleagues alike, and in so doing move us away from nonproductive blame and finger‐pointing.

Although the implications for these standards are far reaching in terms of raising the quality bar, they could reach even further with respect to the types of settings they address. These standards need to extend beyond hospitals and the outpatient arena to include nursing homes, rehabilitation facilities, home care agencies, adult day health centers, and other settings where chronic care services are delivered.

Further, the standards devote considerable focus to the transfer of health information. Even with advances in health information exchange technologies, we must recognize that information is necessary but not sufficient for ensuring safe and high‐quality transfers. Implementing these standards will undoubtedly require that we reconfigure our daily workflows.13 The article in this issue by Graumlich et al.14 emphasizes the challenges of how to introduce technology into our daily clinical routines. The standards also open the door for how we can best ensure not just the transmission of information, but also the comprehension of transfer instructions to our patients with attention to health literacy, cognitive ability, and the patient's level of activation.15 Best and Young16 provide valuable action steps for how to address the needs of diverse and underserved populations.

These standards may serve to uncover the fact that most physicians have not received formal training in executing high‐quality care transitions in the role of either the sender or the receiver. Further, few physicians have a mechanism in place to evaluate their performance. The American Board of Internal Medicine and the American Board of Family Practice has developed Maintenance of Certification Practice Improvement Modules (PIM) on care coordination that provide an excellent opportunity to sharpen our skills. The HMO Care Management Workgroup has also attempted to summarize the essential skills necessary to care for patients during transitions.17

Perhaps the greatest value of these standards is that they lay the framework for actionable improvement. Local, state, and national quality collaboratives can immediately incorporate these recommendations into their overall strategy. These standards will likely influence the design and implementation of the Medical Home.18 As national attention focuses on how to operationalize bundled payment approaches and Accountable Care Organizations,19 these standards provide a clear consensus on communication, accountability, and ensuring patient‐centeredness. The standards are an excellent start and provide a framework for further innovation.

One area in particular may be the opportunity to reinvent the format, content, and medium by which essential information is transferred. For example, one might envision the value of producing a scaled down version of the discharge summary with a limited core set of data elements that could be quickly completed and communicated to the next care team via fax, e‐mail, or text messaging.

Complementing new strategies to improve the exchange of health information are opportunities to reconsider the culture within which this communication occurs. Our profession has a long‐standing tradition of not providing directives to our colleagues on the details of clinical management. Hospitalists develop important insights during a patient's hospital stay and are in an ideal position to anticipate potential developments in the subsequent course after discharge. Contrast this with the 5 to 10 minutes that a primary care physician or specialist may have to come up to speed on the hospital and posthospital events in order to manage the patient in the ambulatory arena. Thus, rather than the traditional historical orientation to a discharge summary, one could envision a more future‐orientated document characterized by a series of if‐then statements that outline a series of possible clinical scenarios that may play out over the weeks after discharge along with recommendations for adjustments to the treatment plan.

At a broader level, the release of these standards demonstrate to our communities and to our nation that physicians can join forces to address a particularly complex and challenging aspect of healthcare. Change can indeed come from within our profession rather than being imposed by outside influences such as government administrators, regulatory bodies, or malpractice attorneys. I applaud such efforts and believe that hospitalists will continue to play a central role in national efforts to improve transitions of care.

References
  1. Kripalani S,Phillips CO,Basaviah P,Williams MV,Saint SK,Baker DW.Deficits in information transfer from inpatient to outpatient physician at hospital discharge: a systematic review.J Gen Intern Med.2004;19(S1):135.
  2. Coleman EA,Berenson RA.Lost in transition: challenges and opportunities for improving the quality of transitional care.Ann Intern Med.2004;141(7):533536.
  3. Kane R,West J.It Shouldn't Be This Way: The Failure of Long Term Care.1st ed.Nashville, TN:Vanderbilt University Press;2005.
  4. Pham HH.Dismantling Rube Goldberg: cutting through chaos to achieve coordinated care.J Hosp Med.2009;4(4):259260.
  5. Levin PE,Levin EJ.The experience of an orthopaedic traumatologist when the trauma hits home: observations and suggestions.J Bone Joint Surg Am.2008;90(9):20262036.
  6. Berwick DM.Quality comes home.Ann Intern Med.1996;125(10):839843.
  7. Lawrence DM.My mother and the medical care ad‐hoc‐racy.Health Aff.2003;22(2):238242.
  8. Cleary P.A hospitalization from hell: a patient's perspective on quality.Ann Intern Med.2003;138:3339.
  9. Boyce PS,Pace KB,Lauder B,Solomon DA.The ReACH Collaborative—improving quality home care.Caring.2007;26(8):4451.
  10. Next step in care. Available at: http://www.nextstepincare.org. Accessed June2009.
  11. Bennett RE,Tuttle M,May K,Harvell J,Coleman EA. Health information exchange in post‐acute and long‐term care case study findings: final report. 2007. Office of Disability, Aging and Long‐Term Care Policy; Office of the Assistant Secretary for Planning and Evaluation; U.S. Department of Health and Human Services. Available at: http://aspe.hhs.gov/daltcp/reports/2007/HIEcase.pdf. Accessed June2009.
  12. Snow V.Transitions of Care Consensus Policy Statement. American College of Physicians‐Society of General Internal Medicine‐Society of Hospital Medicine‐American Geriatrics Society‐American College of Emergency Physicians‐Society of Academic Emergency Medicine.J Hosp Med.2009;4(6):364370.
  13. Chugh A,Williams MV,Grigsby J,Coleman E.Better transitions: improving comprehension of discharge instructions.Front Health Serv Manag.2009;25(3):1132.
  14. Graumlich J,Novotny N,Nace G,Aldag J.Patient and physician perceptions after software‐assisted discharge from hospital: cluster randomized trial.J Hosp Med.2009;4(6):356363.
  15. Patient Activation Measure. Available at: http://www.insigniahealth.com/products/pam.html. Accessed June2009.
  16. Best J,Young A.A SAFE DC: a conceptual framework for care of the homeless inpatient.J Hosp Med2009;4(6):375381.
  17. HMO Care Management Workgroup. One patient, many places: managing healthcare transitions. 2004. Available at: http://www.caretransitions. org/documents/One%20Patient%20RWJ%20Report.pdf. Accessed June2009.
  18. American College of Physicians. Patient‐Centered Medical Home: ACP delivers expanded PCMH resources online. Available at: http://www.acponline.org/advocacy/where_we_stand/medical_home. Accessed June2009.
  19. American College of Physicians. Accountable Care Organizations. Available at: http://www.acponline.org/advocacy/where_we_stand/medical_ home. Accessed June2009.
References
  1. Kripalani S,Phillips CO,Basaviah P,Williams MV,Saint SK,Baker DW.Deficits in information transfer from inpatient to outpatient physician at hospital discharge: a systematic review.J Gen Intern Med.2004;19(S1):135.
  2. Coleman EA,Berenson RA.Lost in transition: challenges and opportunities for improving the quality of transitional care.Ann Intern Med.2004;141(7):533536.
  3. Kane R,West J.It Shouldn't Be This Way: The Failure of Long Term Care.1st ed.Nashville, TN:Vanderbilt University Press;2005.
  4. Pham HH.Dismantling Rube Goldberg: cutting through chaos to achieve coordinated care.J Hosp Med.2009;4(4):259260.
  5. Levin PE,Levin EJ.The experience of an orthopaedic traumatologist when the trauma hits home: observations and suggestions.J Bone Joint Surg Am.2008;90(9):20262036.
  6. Berwick DM.Quality comes home.Ann Intern Med.1996;125(10):839843.
  7. Lawrence DM.My mother and the medical care ad‐hoc‐racy.Health Aff.2003;22(2):238242.
  8. Cleary P.A hospitalization from hell: a patient's perspective on quality.Ann Intern Med.2003;138:3339.
  9. Boyce PS,Pace KB,Lauder B,Solomon DA.The ReACH Collaborative—improving quality home care.Caring.2007;26(8):4451.
  10. Next step in care. Available at: http://www.nextstepincare.org. Accessed June2009.
  11. Bennett RE,Tuttle M,May K,Harvell J,Coleman EA. Health information exchange in post‐acute and long‐term care case study findings: final report. 2007. Office of Disability, Aging and Long‐Term Care Policy; Office of the Assistant Secretary for Planning and Evaluation; U.S. Department of Health and Human Services. Available at: http://aspe.hhs.gov/daltcp/reports/2007/HIEcase.pdf. Accessed June2009.
  12. Snow V.Transitions of Care Consensus Policy Statement. American College of Physicians‐Society of General Internal Medicine‐Society of Hospital Medicine‐American Geriatrics Society‐American College of Emergency Physicians‐Society of Academic Emergency Medicine.J Hosp Med.2009;4(6):364370.
  13. Chugh A,Williams MV,Grigsby J,Coleman E.Better transitions: improving comprehension of discharge instructions.Front Health Serv Manag.2009;25(3):1132.
  14. Graumlich J,Novotny N,Nace G,Aldag J.Patient and physician perceptions after software‐assisted discharge from hospital: cluster randomized trial.J Hosp Med.2009;4(6):356363.
  15. Patient Activation Measure. Available at: http://www.insigniahealth.com/products/pam.html. Accessed June2009.
  16. Best J,Young A.A SAFE DC: a conceptual framework for care of the homeless inpatient.J Hosp Med2009;4(6):375381.
  17. HMO Care Management Workgroup. One patient, many places: managing healthcare transitions. 2004. Available at: http://www.caretransitions. org/documents/One%20Patient%20RWJ%20Report.pdf. Accessed June2009.
  18. American College of Physicians. Patient‐Centered Medical Home: ACP delivers expanded PCMH resources online. Available at: http://www.acponline.org/advocacy/where_we_stand/medical_home. Accessed June2009.
  19. American College of Physicians. Accountable Care Organizations. Available at: http://www.acponline.org/advocacy/where_we_stand/medical_ home. Accessed June2009.
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The new data on prostate cancer screening: What should we do now?

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The new data on prostate cancer screening: What should we do now?

This edition of the Cleveland Clinic Journal of Medicine includes a timely update on prostate cancer screening and prevention by a leading international expert, Dr. Eric Klein.1 At long last, 2009 brought the publication of two large prostate cancer screening trials.2,3 Randomized controlled trials had been needed to discover whether screening had a benefit.

See related article

Now that we have the data, was it worth the wait? Do we know the answer? Should our male patients, our male loved ones, and those of us who are men have prostate-specific antigen (PSA) tests?

DOES EARLIER DIAGNOSIS HELP OR HARM?

Over the past 20 years, PSA screening and other developments have transformed the presentation of prostate cancer in regions where PSA testing is common. The incidence of prostate cancer that was metastatic at the time of diagnosis fell by 56% between 1985 and 1995.4 The proportion of cancers that were localized in the mid-1980s was 58%, compared with 80% now, while only 4% now have metastases at diagnosis.5

This early detection had a predictable effect on 5-year relative survival, which increased from 69% in the mid-1970s and 84% in the late 1980s to 99.9% in the early 21st century.5 Prostate cancer now has the highest 5-year relative survival of any cancer except non-melanoma skin cancer.

This doesn’t mean that prostate cancer doesn’t kill men, but only that it almost always takes longer than 5 years from diagnosis. More than 27,000 Americans die of prostate cancer annually—lung cancer is the only malignancy that kills more men. Nonetheless, that 27,000 is a small fraction of the 192,000 men diagnosed with prostate cancer each year. And it is worth keeping in mind that autopsy studies show that most men have cancer in their prostates by the time they reach age 70, while the Prostate Cancer Prevention Trial reported that 24% of men at least 55 years old have prostate cancer detectable by biopsy, including 15% of men who have a serum PSA less than 4.0 ng/mL and a normal digital rectal examination.6,7

Prostate cancer is thus highly prevalent, usually indolent, but sometimes deadly. Overtreatment of indolent disease and ineffective treatment of aggressive disease continue to represent major challenges.

As prostate cancer survival has lengthened, the prostate cancer death rate has declined, although to a lesser extent. The death rate from prostate cancer per 100,000 US males was 31 in 1975, climbed to 39 in 1990, and then declined to 25 in 2005, a 19% reduction over 30 years. Viewed differently, the lifetime risk of being diagnosed with prostate cancer increased from 13% in 1990 to 16% in 2006, while the risk of dying from it declined from 3.2% to 2.8%.5

This reduction in death rate was interpreted by some as evidence that PSA screening is effective, but it was impossible to control for confounding variables such as improvements in treatment. It was clear that PSA testing provided earlier diagnosis and hence longer survival from the time of diagnosis, but it was not clear whether it resulted in men living longer. Given the numerous kinds of serious harm that can follow from a diagnosis of prostate cancer in the form of anxiety, treatment side effects, and medical expenses, early diagnosis could easily represent a net harm.

THE EUROPEAN PROSTATE CANCER SCREENING TRIAL

To address the question of whether prostate cancer screening with PSA testing lowers a man’s risk of dying of prostate cancer, Europe and the United States each initiated randomized controlled trials.

The European study2 randomized 162,000 men, age 55 to 69 years, to one of two groups. One group was offered PSA screening, the other was not. In those screened, PSA testing was repeated once every 4 years on average. Most centers participating in the trial used a PSA above 3.0 ng/mL as the threshold for biopsy. In the screening group, 82% of the men had at least one PSA test, 16% of all PSA tests were positive, and 86% of men who had an elevated PSA value underwent a biopsy. Of those undergoing biopsy for an elevated PSA, 76% had benign results, which shows that PSA as a test for cancer has a high false-positive rate.

As expected, screening increased the rate of prostate cancer detection. The rate was 70% higher in the screening group: 8.2% of men in the screening group were diagnosed, compared with 4.8% in the control group. Men undergoing screening were more likely to have localized disease and 41% less likely to have metastatic disease. The increased number of cancers detected by screening were predominantly less-aggressive tumors: the incidence of low- and intermediate-grade cancers (Gleason score 2 to 6) was 4.8% in the screened group vs 1.7% in the control group. Screened men had a lower proportion (28% vs 45%) but a higher incidence (1.9% vs 1.4%) of high-grade cancers (Gleason score 7 or higher). It is this tendency of screening to preferentially detect indolent cancers that results in length-time bias.

So did PSA testing lower the risk of death from prostate cancer? In the European trial it did, and by 20% (95% confidence interval 5%–33%, P = .01). This study thus provided level-1 evidence that PSA testing to screen for prostate cancer reduces prostate cancer mortality rates.

However, more than 1,400 men needed to be screened and 48 needed to be treated for each death prevented. Moreover, because fewer than 3% of men die of prostate cancer, lowering the risk of death from prostate cancer does not result in an appreciable effect on all-cause mortality or on life expectancy. We cannot say that men live longer as a result of prostate cancer screening—only that they are less likely to die of prostate cancer.

 

 

THE US SCREENING TRIAL

What about the US trial? Unfortunately, it was beset by limitations that make its interpretation extremely difficult.3

Between 1993 and 2001, 76,693 men were randomized to prostate cancer screening with PSA testing and digital rectal examination, or else to usual care.

The problem is that in the United States “usual care” often includes PSA testing. Thus, 34% of men participating in the trial had had a PSA test within 3 years prior to enrolling on the trial, and 52% of the control group had PSA testing during the trial. In the group randomized to screening, 85% complied with PSA testing. This trial thus compared one group in which most were screened at least once against another group in which 85% were screened regularly. Rather than asking whether screening is effective, the trial compared two different PSA screening schedules.

Thus, it was no surprise that there was less than a 25% increase in the cancer detection rate and less than a 30% reduction in the likelihood of having detectable metastatic disease at the time of diagnosis. And after 7 years of follow-up, the two groups showed no statistically significant difference in the likelihood of dying of prostate cancer.

SHOULD MEN BE SCREENED FOR PROSTATE CANCER?

The European trial provides strong evidence that PSA testing reduces prostate cancer mortality rates,2 while the US trial sheds little light on the subject. But does this mean that men should be screened routinely?

It’s not that simple. The 75% false-positive rate of PSA testing and the high number needed to treat (n = 48) to save one life represent significant harmful effects of prostate cancer screening that must be factored into the decision-making process. And we know from other studies that half or more of men undergoing prostate cancer treatment will report erectile dysfunction, while a smaller number will experience urinary incontinence. More and more men without detectable meta-static disease are being treated with medical or surgical castration, which is associated with loss of libido, osteoporosis, weight gain, loss of muscle, and an increased risk of diabetes and death from cardiovascular disease. Prostate cancer treatments also result in large medical bills, which are a source of hardship for the increasing number of Americans with inadequate health insurance.

The benefit of PSA testing is limited by several key facts:

  • It is an inaccurate test with a high false-positive rate
  • The treatment of prostate cancer results in serious adverse effects
  • Most men will develop prostate cancer if they live into their 70s
  • Most prostate cancers are not life-threatening.

Whereas cervical cancer screening typically detects precancerous lesions that can be treated superficially and colon cancer and breast cancer screening often detect precancerous lesions or small tumors that can be removed with relatively minor surgery, prostate cancer treatment is radical and often results in significant long-term adverse effects. The benefits of PSA screening must be balanced against the harm.

One way out of this dilemma, as discussed in Dr. Klein’s article, is to eliminate the reflex progression from PSA elevation to biopsy and from positive biopsy to treatment. As Dr. Klein discusses, variables other then PSA help predict the likelihood that a biopsy would detect a clinically significant cancer and can reduce the likelihood of performing unnecessary biopsies.1

Similarly, there is growing interest in active surveillance for clinically localized low- or intermediate-grade prostate cancers, thus sparing men unnecessary and aggressive treatment.8 The challenge is determining which cancers are indolent and which are aggressive. Until we have accurate tools to make such a distinction, overtreatment will remain a problem as men and their doctors opt for aggressive treatment in the face of uncertainty about a cancer’s true danger.

MOVING FORWARD

This year has brought strong evidence that PSA screening lowers the risk of dying of prostate cancer, but at a cost of overdiagnosis, overtreatment, and a significant burden of treatment side effects and costs. Moving forward will depend on a more sensitive and specific screening test, tools for better predicting which cancers actually need treatment, and treatments that result in fewer long-term side effects. Progress on all these fronts can be expected in the future.

References
  1. Klein E. What’s new in prostate cancer screening and prevention? Cleve Clin J Med 2009; 76:439445.
  2. Schröder FH, Hugosson J, Roobol MJ, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 2009; 360:13201328.
  3. Andriole GL, Crawford ED, Grubb RL, et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009; 360:13101319.
  4. Stanford JL, Stephenson RA, Coyle LM, et al. Prostate Cancer Trends 1973–1995. Bethesda, MD: National Cancer Institute; 1999.
  5. Horner MJ, Ries LAG, Krapcho M, et al, editors. SEER Cancer Statistics Review, 1975–2006. Bethesda, MD: National Cancer Institute; 2009.
  6. Sakr WA, Grignon DJ, Crissman JD, et al High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo 1994; 8:439443.
  7. Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349:215224.
  8. Klotz L. Active surveillance for favorable-risk prostate cancer: who, how and why? Nat Clin Pract Oncol 2007; 4:692698.
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This edition of the Cleveland Clinic Journal of Medicine includes a timely update on prostate cancer screening and prevention by a leading international expert, Dr. Eric Klein.1 At long last, 2009 brought the publication of two large prostate cancer screening trials.2,3 Randomized controlled trials had been needed to discover whether screening had a benefit.

See related article

Now that we have the data, was it worth the wait? Do we know the answer? Should our male patients, our male loved ones, and those of us who are men have prostate-specific antigen (PSA) tests?

DOES EARLIER DIAGNOSIS HELP OR HARM?

Over the past 20 years, PSA screening and other developments have transformed the presentation of prostate cancer in regions where PSA testing is common. The incidence of prostate cancer that was metastatic at the time of diagnosis fell by 56% between 1985 and 1995.4 The proportion of cancers that were localized in the mid-1980s was 58%, compared with 80% now, while only 4% now have metastases at diagnosis.5

This early detection had a predictable effect on 5-year relative survival, which increased from 69% in the mid-1970s and 84% in the late 1980s to 99.9% in the early 21st century.5 Prostate cancer now has the highest 5-year relative survival of any cancer except non-melanoma skin cancer.

This doesn’t mean that prostate cancer doesn’t kill men, but only that it almost always takes longer than 5 years from diagnosis. More than 27,000 Americans die of prostate cancer annually—lung cancer is the only malignancy that kills more men. Nonetheless, that 27,000 is a small fraction of the 192,000 men diagnosed with prostate cancer each year. And it is worth keeping in mind that autopsy studies show that most men have cancer in their prostates by the time they reach age 70, while the Prostate Cancer Prevention Trial reported that 24% of men at least 55 years old have prostate cancer detectable by biopsy, including 15% of men who have a serum PSA less than 4.0 ng/mL and a normal digital rectal examination.6,7

Prostate cancer is thus highly prevalent, usually indolent, but sometimes deadly. Overtreatment of indolent disease and ineffective treatment of aggressive disease continue to represent major challenges.

As prostate cancer survival has lengthened, the prostate cancer death rate has declined, although to a lesser extent. The death rate from prostate cancer per 100,000 US males was 31 in 1975, climbed to 39 in 1990, and then declined to 25 in 2005, a 19% reduction over 30 years. Viewed differently, the lifetime risk of being diagnosed with prostate cancer increased from 13% in 1990 to 16% in 2006, while the risk of dying from it declined from 3.2% to 2.8%.5

This reduction in death rate was interpreted by some as evidence that PSA screening is effective, but it was impossible to control for confounding variables such as improvements in treatment. It was clear that PSA testing provided earlier diagnosis and hence longer survival from the time of diagnosis, but it was not clear whether it resulted in men living longer. Given the numerous kinds of serious harm that can follow from a diagnosis of prostate cancer in the form of anxiety, treatment side effects, and medical expenses, early diagnosis could easily represent a net harm.

THE EUROPEAN PROSTATE CANCER SCREENING TRIAL

To address the question of whether prostate cancer screening with PSA testing lowers a man’s risk of dying of prostate cancer, Europe and the United States each initiated randomized controlled trials.

The European study2 randomized 162,000 men, age 55 to 69 years, to one of two groups. One group was offered PSA screening, the other was not. In those screened, PSA testing was repeated once every 4 years on average. Most centers participating in the trial used a PSA above 3.0 ng/mL as the threshold for biopsy. In the screening group, 82% of the men had at least one PSA test, 16% of all PSA tests were positive, and 86% of men who had an elevated PSA value underwent a biopsy. Of those undergoing biopsy for an elevated PSA, 76% had benign results, which shows that PSA as a test for cancer has a high false-positive rate.

As expected, screening increased the rate of prostate cancer detection. The rate was 70% higher in the screening group: 8.2% of men in the screening group were diagnosed, compared with 4.8% in the control group. Men undergoing screening were more likely to have localized disease and 41% less likely to have metastatic disease. The increased number of cancers detected by screening were predominantly less-aggressive tumors: the incidence of low- and intermediate-grade cancers (Gleason score 2 to 6) was 4.8% in the screened group vs 1.7% in the control group. Screened men had a lower proportion (28% vs 45%) but a higher incidence (1.9% vs 1.4%) of high-grade cancers (Gleason score 7 or higher). It is this tendency of screening to preferentially detect indolent cancers that results in length-time bias.

So did PSA testing lower the risk of death from prostate cancer? In the European trial it did, and by 20% (95% confidence interval 5%–33%, P = .01). This study thus provided level-1 evidence that PSA testing to screen for prostate cancer reduces prostate cancer mortality rates.

However, more than 1,400 men needed to be screened and 48 needed to be treated for each death prevented. Moreover, because fewer than 3% of men die of prostate cancer, lowering the risk of death from prostate cancer does not result in an appreciable effect on all-cause mortality or on life expectancy. We cannot say that men live longer as a result of prostate cancer screening—only that they are less likely to die of prostate cancer.

 

 

THE US SCREENING TRIAL

What about the US trial? Unfortunately, it was beset by limitations that make its interpretation extremely difficult.3

Between 1993 and 2001, 76,693 men were randomized to prostate cancer screening with PSA testing and digital rectal examination, or else to usual care.

The problem is that in the United States “usual care” often includes PSA testing. Thus, 34% of men participating in the trial had had a PSA test within 3 years prior to enrolling on the trial, and 52% of the control group had PSA testing during the trial. In the group randomized to screening, 85% complied with PSA testing. This trial thus compared one group in which most were screened at least once against another group in which 85% were screened regularly. Rather than asking whether screening is effective, the trial compared two different PSA screening schedules.

Thus, it was no surprise that there was less than a 25% increase in the cancer detection rate and less than a 30% reduction in the likelihood of having detectable metastatic disease at the time of diagnosis. And after 7 years of follow-up, the two groups showed no statistically significant difference in the likelihood of dying of prostate cancer.

SHOULD MEN BE SCREENED FOR PROSTATE CANCER?

The European trial provides strong evidence that PSA testing reduces prostate cancer mortality rates,2 while the US trial sheds little light on the subject. But does this mean that men should be screened routinely?

It’s not that simple. The 75% false-positive rate of PSA testing and the high number needed to treat (n = 48) to save one life represent significant harmful effects of prostate cancer screening that must be factored into the decision-making process. And we know from other studies that half or more of men undergoing prostate cancer treatment will report erectile dysfunction, while a smaller number will experience urinary incontinence. More and more men without detectable meta-static disease are being treated with medical or surgical castration, which is associated with loss of libido, osteoporosis, weight gain, loss of muscle, and an increased risk of diabetes and death from cardiovascular disease. Prostate cancer treatments also result in large medical bills, which are a source of hardship for the increasing number of Americans with inadequate health insurance.

The benefit of PSA testing is limited by several key facts:

  • It is an inaccurate test with a high false-positive rate
  • The treatment of prostate cancer results in serious adverse effects
  • Most men will develop prostate cancer if they live into their 70s
  • Most prostate cancers are not life-threatening.

Whereas cervical cancer screening typically detects precancerous lesions that can be treated superficially and colon cancer and breast cancer screening often detect precancerous lesions or small tumors that can be removed with relatively minor surgery, prostate cancer treatment is radical and often results in significant long-term adverse effects. The benefits of PSA screening must be balanced against the harm.

One way out of this dilemma, as discussed in Dr. Klein’s article, is to eliminate the reflex progression from PSA elevation to biopsy and from positive biopsy to treatment. As Dr. Klein discusses, variables other then PSA help predict the likelihood that a biopsy would detect a clinically significant cancer and can reduce the likelihood of performing unnecessary biopsies.1

Similarly, there is growing interest in active surveillance for clinically localized low- or intermediate-grade prostate cancers, thus sparing men unnecessary and aggressive treatment.8 The challenge is determining which cancers are indolent and which are aggressive. Until we have accurate tools to make such a distinction, overtreatment will remain a problem as men and their doctors opt for aggressive treatment in the face of uncertainty about a cancer’s true danger.

MOVING FORWARD

This year has brought strong evidence that PSA screening lowers the risk of dying of prostate cancer, but at a cost of overdiagnosis, overtreatment, and a significant burden of treatment side effects and costs. Moving forward will depend on a more sensitive and specific screening test, tools for better predicting which cancers actually need treatment, and treatments that result in fewer long-term side effects. Progress on all these fronts can be expected in the future.

This edition of the Cleveland Clinic Journal of Medicine includes a timely update on prostate cancer screening and prevention by a leading international expert, Dr. Eric Klein.1 At long last, 2009 brought the publication of two large prostate cancer screening trials.2,3 Randomized controlled trials had been needed to discover whether screening had a benefit.

See related article

Now that we have the data, was it worth the wait? Do we know the answer? Should our male patients, our male loved ones, and those of us who are men have prostate-specific antigen (PSA) tests?

DOES EARLIER DIAGNOSIS HELP OR HARM?

Over the past 20 years, PSA screening and other developments have transformed the presentation of prostate cancer in regions where PSA testing is common. The incidence of prostate cancer that was metastatic at the time of diagnosis fell by 56% between 1985 and 1995.4 The proportion of cancers that were localized in the mid-1980s was 58%, compared with 80% now, while only 4% now have metastases at diagnosis.5

This early detection had a predictable effect on 5-year relative survival, which increased from 69% in the mid-1970s and 84% in the late 1980s to 99.9% in the early 21st century.5 Prostate cancer now has the highest 5-year relative survival of any cancer except non-melanoma skin cancer.

This doesn’t mean that prostate cancer doesn’t kill men, but only that it almost always takes longer than 5 years from diagnosis. More than 27,000 Americans die of prostate cancer annually—lung cancer is the only malignancy that kills more men. Nonetheless, that 27,000 is a small fraction of the 192,000 men diagnosed with prostate cancer each year. And it is worth keeping in mind that autopsy studies show that most men have cancer in their prostates by the time they reach age 70, while the Prostate Cancer Prevention Trial reported that 24% of men at least 55 years old have prostate cancer detectable by biopsy, including 15% of men who have a serum PSA less than 4.0 ng/mL and a normal digital rectal examination.6,7

Prostate cancer is thus highly prevalent, usually indolent, but sometimes deadly. Overtreatment of indolent disease and ineffective treatment of aggressive disease continue to represent major challenges.

As prostate cancer survival has lengthened, the prostate cancer death rate has declined, although to a lesser extent. The death rate from prostate cancer per 100,000 US males was 31 in 1975, climbed to 39 in 1990, and then declined to 25 in 2005, a 19% reduction over 30 years. Viewed differently, the lifetime risk of being diagnosed with prostate cancer increased from 13% in 1990 to 16% in 2006, while the risk of dying from it declined from 3.2% to 2.8%.5

This reduction in death rate was interpreted by some as evidence that PSA screening is effective, but it was impossible to control for confounding variables such as improvements in treatment. It was clear that PSA testing provided earlier diagnosis and hence longer survival from the time of diagnosis, but it was not clear whether it resulted in men living longer. Given the numerous kinds of serious harm that can follow from a diagnosis of prostate cancer in the form of anxiety, treatment side effects, and medical expenses, early diagnosis could easily represent a net harm.

THE EUROPEAN PROSTATE CANCER SCREENING TRIAL

To address the question of whether prostate cancer screening with PSA testing lowers a man’s risk of dying of prostate cancer, Europe and the United States each initiated randomized controlled trials.

The European study2 randomized 162,000 men, age 55 to 69 years, to one of two groups. One group was offered PSA screening, the other was not. In those screened, PSA testing was repeated once every 4 years on average. Most centers participating in the trial used a PSA above 3.0 ng/mL as the threshold for biopsy. In the screening group, 82% of the men had at least one PSA test, 16% of all PSA tests were positive, and 86% of men who had an elevated PSA value underwent a biopsy. Of those undergoing biopsy for an elevated PSA, 76% had benign results, which shows that PSA as a test for cancer has a high false-positive rate.

As expected, screening increased the rate of prostate cancer detection. The rate was 70% higher in the screening group: 8.2% of men in the screening group were diagnosed, compared with 4.8% in the control group. Men undergoing screening were more likely to have localized disease and 41% less likely to have metastatic disease. The increased number of cancers detected by screening were predominantly less-aggressive tumors: the incidence of low- and intermediate-grade cancers (Gleason score 2 to 6) was 4.8% in the screened group vs 1.7% in the control group. Screened men had a lower proportion (28% vs 45%) but a higher incidence (1.9% vs 1.4%) of high-grade cancers (Gleason score 7 or higher). It is this tendency of screening to preferentially detect indolent cancers that results in length-time bias.

So did PSA testing lower the risk of death from prostate cancer? In the European trial it did, and by 20% (95% confidence interval 5%–33%, P = .01). This study thus provided level-1 evidence that PSA testing to screen for prostate cancer reduces prostate cancer mortality rates.

However, more than 1,400 men needed to be screened and 48 needed to be treated for each death prevented. Moreover, because fewer than 3% of men die of prostate cancer, lowering the risk of death from prostate cancer does not result in an appreciable effect on all-cause mortality or on life expectancy. We cannot say that men live longer as a result of prostate cancer screening—only that they are less likely to die of prostate cancer.

 

 

THE US SCREENING TRIAL

What about the US trial? Unfortunately, it was beset by limitations that make its interpretation extremely difficult.3

Between 1993 and 2001, 76,693 men were randomized to prostate cancer screening with PSA testing and digital rectal examination, or else to usual care.

The problem is that in the United States “usual care” often includes PSA testing. Thus, 34% of men participating in the trial had had a PSA test within 3 years prior to enrolling on the trial, and 52% of the control group had PSA testing during the trial. In the group randomized to screening, 85% complied with PSA testing. This trial thus compared one group in which most were screened at least once against another group in which 85% were screened regularly. Rather than asking whether screening is effective, the trial compared two different PSA screening schedules.

Thus, it was no surprise that there was less than a 25% increase in the cancer detection rate and less than a 30% reduction in the likelihood of having detectable metastatic disease at the time of diagnosis. And after 7 years of follow-up, the two groups showed no statistically significant difference in the likelihood of dying of prostate cancer.

SHOULD MEN BE SCREENED FOR PROSTATE CANCER?

The European trial provides strong evidence that PSA testing reduces prostate cancer mortality rates,2 while the US trial sheds little light on the subject. But does this mean that men should be screened routinely?

It’s not that simple. The 75% false-positive rate of PSA testing and the high number needed to treat (n = 48) to save one life represent significant harmful effects of prostate cancer screening that must be factored into the decision-making process. And we know from other studies that half or more of men undergoing prostate cancer treatment will report erectile dysfunction, while a smaller number will experience urinary incontinence. More and more men without detectable meta-static disease are being treated with medical or surgical castration, which is associated with loss of libido, osteoporosis, weight gain, loss of muscle, and an increased risk of diabetes and death from cardiovascular disease. Prostate cancer treatments also result in large medical bills, which are a source of hardship for the increasing number of Americans with inadequate health insurance.

The benefit of PSA testing is limited by several key facts:

  • It is an inaccurate test with a high false-positive rate
  • The treatment of prostate cancer results in serious adverse effects
  • Most men will develop prostate cancer if they live into their 70s
  • Most prostate cancers are not life-threatening.

Whereas cervical cancer screening typically detects precancerous lesions that can be treated superficially and colon cancer and breast cancer screening often detect precancerous lesions or small tumors that can be removed with relatively minor surgery, prostate cancer treatment is radical and often results in significant long-term adverse effects. The benefits of PSA screening must be balanced against the harm.

One way out of this dilemma, as discussed in Dr. Klein’s article, is to eliminate the reflex progression from PSA elevation to biopsy and from positive biopsy to treatment. As Dr. Klein discusses, variables other then PSA help predict the likelihood that a biopsy would detect a clinically significant cancer and can reduce the likelihood of performing unnecessary biopsies.1

Similarly, there is growing interest in active surveillance for clinically localized low- or intermediate-grade prostate cancers, thus sparing men unnecessary and aggressive treatment.8 The challenge is determining which cancers are indolent and which are aggressive. Until we have accurate tools to make such a distinction, overtreatment will remain a problem as men and their doctors opt for aggressive treatment in the face of uncertainty about a cancer’s true danger.

MOVING FORWARD

This year has brought strong evidence that PSA screening lowers the risk of dying of prostate cancer, but at a cost of overdiagnosis, overtreatment, and a significant burden of treatment side effects and costs. Moving forward will depend on a more sensitive and specific screening test, tools for better predicting which cancers actually need treatment, and treatments that result in fewer long-term side effects. Progress on all these fronts can be expected in the future.

References
  1. Klein E. What’s new in prostate cancer screening and prevention? Cleve Clin J Med 2009; 76:439445.
  2. Schröder FH, Hugosson J, Roobol MJ, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 2009; 360:13201328.
  3. Andriole GL, Crawford ED, Grubb RL, et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009; 360:13101319.
  4. Stanford JL, Stephenson RA, Coyle LM, et al. Prostate Cancer Trends 1973–1995. Bethesda, MD: National Cancer Institute; 1999.
  5. Horner MJ, Ries LAG, Krapcho M, et al, editors. SEER Cancer Statistics Review, 1975–2006. Bethesda, MD: National Cancer Institute; 2009.
  6. Sakr WA, Grignon DJ, Crissman JD, et al High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo 1994; 8:439443.
  7. Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349:215224.
  8. Klotz L. Active surveillance for favorable-risk prostate cancer: who, how and why? Nat Clin Pract Oncol 2007; 4:692698.
References
  1. Klein E. What’s new in prostate cancer screening and prevention? Cleve Clin J Med 2009; 76:439445.
  2. Schröder FH, Hugosson J, Roobol MJ, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 2009; 360:13201328.
  3. Andriole GL, Crawford ED, Grubb RL, et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009; 360:13101319.
  4. Stanford JL, Stephenson RA, Coyle LM, et al. Prostate Cancer Trends 1973–1995. Bethesda, MD: National Cancer Institute; 1999.
  5. Horner MJ, Ries LAG, Krapcho M, et al, editors. SEER Cancer Statistics Review, 1975–2006. Bethesda, MD: National Cancer Institute; 2009.
  6. Sakr WA, Grignon DJ, Crissman JD, et al High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo 1994; 8:439443.
  7. Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349:215224.
  8. Klotz L. Active surveillance for favorable-risk prostate cancer: who, how and why? Nat Clin Pract Oncol 2007; 4:692698.
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Cleveland Clinic Journal of Medicine - 76(8)
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Cleveland Clinic Journal of Medicine - 76(8)
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