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Erythema Dyschromicum Perstans: Successful Treatment With Clofazimine Under a Single-Patient Investigational New Drug Study

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erythema, dyschromia, clofazinmine, EDP, hypermelanosis, New Drug Studyerythema, dyschromia, clofazinmine, EDP, hypermelanosis, New Drug Study, Micciantuono SR, Cardona L, Pinzon-Plazas M, Rendon M
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Erythema Dyschromicum Perstans: Successful Treatment With Clofazimine Under a Single-Patient Investigational New Drug Study
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Mechanisms of Action of Azelaic Acid 15% Gel: Assessing Its Broad Antioxidant and Comedolytic Effects

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Mechanisms of Action of Azelaic Acid 15% Gel: Assessing Its Broad Antioxidant and Comedolytic Effects
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Efficacious and Safe Cosmetic Procedures in Skin of Color

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cosmetic procedures, skin of color, cutaneous surgery, dyschromia, postinflammatory hyperpigmentation, peeling agents, microdermabrasion, botulinum toxin, dermal fillers, Pearl E. Grimescosmetic procedures, skin of color, cutaneous surgery, dyschromia, postinflammatory hyperpigmentation, peeling agents, microdermabrasion, botulinum toxin, dermal fillers, Pearl E. Grimes
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Efficacious and Safe Cosmetic Procedures in Skin of Color
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A Stepwise Approach to Melasma Management and Treatment

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A Stepwise Approach to Melasma Management and Treatment

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A Stepwise Approach to Melasma Management and Treatment
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Bathing Trunks Nevus: Case Report of Giant Congenital Melanocytic Nevus

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Bathing Trunks Nevus: Case Report of Giant Congenital Melanocytic Nevus

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Bathing Trunks Nevus: Case Report of Giant Congenital Melanocytic Nevus
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Diode Laser Tx Clears Dermatosis Papulosis Nigra : Of the lesions, 98% cleared or improved.

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Diode Laser Tx Clears Dermatosis Papulosis Nigra : Of the lesions, 98% cleared or improved.

PHOENIX — A 532-nm diode laser was highly effective at clearing extensive dermatosis papulosis nigra lesions while avoiding the pigmentary complications that are the bane of conventional treatments for this disorder of darker skin, according to the results of a study involving 40 patients with a total of 1,312 lesions.

In the study, patients with Fitzgerald skin types IV-VI were treated with the Iridex 532-nm KTP DioLiteXP laser for extensive lesions of dermatosis papulosis nigra (DPN) that they found distressing and aesthetically unappealing, Dr. Ayman El-Attar said at the annual meeting of the American Academy of Cosmetic Surgery.

Of the 1,312 DPN lesions on the face, neck, and upper torso addressed over the course of three or four sessions, 98% were cleared or significantly improved at follow-up. The other 2% were located close to the eyelid margins, so Dr. El-Attar elected to leave them untreated.

“Using eye shields, you could easily treat those,” however, noted Dr. El-Attar, who is a laser and cosmetic skin surgeon in Somerset, N.J.

For purposes of the study, efficacy and patient satisfaction were assessed 4 weeks after each treatment session and again 6 months after the final treatment. Patient evaluations of their outcome ranged from “satisfied” to “very satisfied.”

The 532-nm DioliteXP laser, a diode-pumped, frequency-doubled Nd:YAG laser, is widely used in office-based dermatology for treatment of facial telangiectasias.

The green light wavelength laser is extremely lightweight, affordable, easy to use, and readily moved between treatment rooms. The small spot size and limited depth of penetration permit the operator to avoid laser-induced purpura, Dr. El-Attar explained.

The 532-nm diode laser enables patients being treated for DPN to go straight back to work with no downtime for recovery. The key to excellent results, Dr. El-Attar stressed, is to treat cautiously, spreading the work over three or four sessions separated by about 4 weeks in patients with numerous lesions.

“The end point of treating these lesions is graying of the lesion. You don't want to go past this end point. Because African Americans and others with darker skin types are very prone to pigmentary changes, we try to be very conservative. That's why we use several sessions. We never go overboard. We always undertreat,” he said.

Depending upon the size and thickness of a lesion, he uses a repetition rate of 5-7 Hz at 10-16 J/cm

Most patients can tolerate the procedure without a topical anesthetic. When needed, Dr. El-Attar applies EMLA cream for about 15 minutes prior to treatment.

The treated lesions immediately turn gray and then become black and exfoliate over the course of a few days to a week. Because patients occasionally have developed mild itching as a reaction to topical antibiotics, Dr. El-Attar generally has patients apply Vaseline or another bland oil-based topical product to treated areas as they heal.

“Occasionally there are footprints: changes in coloration where the lesions were. The easiest treatment for this is tincture of time, but if the patient is in a rush we can do some mild chemical peeling and that takes care of it 100%,” he said in an interview.

Dermatosis papulosis nigra is an extremely common benign cutaneous condition in African Americans and others who have Fitzgerald skin types IV-VI. DPN is believed to have a strong genetic component and is analogous to seborrheic keratoses in lighter-skinned patients. The small, hyperpigmented lesions tend to become numerous through adulthood.

Conventional treatments of DPN include cryotherapy, curettage, excision, and electrodesiccation. All are notoriously associated with increased risks of hyper- and hypopigmentation in darker skin types, said Dr. El-Attar, who had no financial conflicts of interest to disclose in connection with this study.

This patient—like the others in the study—was distressed by her lesions.

Significant clearance can be seen after treatment with the 532-nm laser. PHOTOS COURTESY DR. AYMAN EL-ATTAR

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PHOENIX — A 532-nm diode laser was highly effective at clearing extensive dermatosis papulosis nigra lesions while avoiding the pigmentary complications that are the bane of conventional treatments for this disorder of darker skin, according to the results of a study involving 40 patients with a total of 1,312 lesions.

In the study, patients with Fitzgerald skin types IV-VI were treated with the Iridex 532-nm KTP DioLiteXP laser for extensive lesions of dermatosis papulosis nigra (DPN) that they found distressing and aesthetically unappealing, Dr. Ayman El-Attar said at the annual meeting of the American Academy of Cosmetic Surgery.

Of the 1,312 DPN lesions on the face, neck, and upper torso addressed over the course of three or four sessions, 98% were cleared or significantly improved at follow-up. The other 2% were located close to the eyelid margins, so Dr. El-Attar elected to leave them untreated.

“Using eye shields, you could easily treat those,” however, noted Dr. El-Attar, who is a laser and cosmetic skin surgeon in Somerset, N.J.

For purposes of the study, efficacy and patient satisfaction were assessed 4 weeks after each treatment session and again 6 months after the final treatment. Patient evaluations of their outcome ranged from “satisfied” to “very satisfied.”

The 532-nm DioliteXP laser, a diode-pumped, frequency-doubled Nd:YAG laser, is widely used in office-based dermatology for treatment of facial telangiectasias.

The green light wavelength laser is extremely lightweight, affordable, easy to use, and readily moved between treatment rooms. The small spot size and limited depth of penetration permit the operator to avoid laser-induced purpura, Dr. El-Attar explained.

The 532-nm diode laser enables patients being treated for DPN to go straight back to work with no downtime for recovery. The key to excellent results, Dr. El-Attar stressed, is to treat cautiously, spreading the work over three or four sessions separated by about 4 weeks in patients with numerous lesions.

“The end point of treating these lesions is graying of the lesion. You don't want to go past this end point. Because African Americans and others with darker skin types are very prone to pigmentary changes, we try to be very conservative. That's why we use several sessions. We never go overboard. We always undertreat,” he said.

Depending upon the size and thickness of a lesion, he uses a repetition rate of 5-7 Hz at 10-16 J/cm

Most patients can tolerate the procedure without a topical anesthetic. When needed, Dr. El-Attar applies EMLA cream for about 15 minutes prior to treatment.

The treated lesions immediately turn gray and then become black and exfoliate over the course of a few days to a week. Because patients occasionally have developed mild itching as a reaction to topical antibiotics, Dr. El-Attar generally has patients apply Vaseline or another bland oil-based topical product to treated areas as they heal.

“Occasionally there are footprints: changes in coloration where the lesions were. The easiest treatment for this is tincture of time, but if the patient is in a rush we can do some mild chemical peeling and that takes care of it 100%,” he said in an interview.

Dermatosis papulosis nigra is an extremely common benign cutaneous condition in African Americans and others who have Fitzgerald skin types IV-VI. DPN is believed to have a strong genetic component and is analogous to seborrheic keratoses in lighter-skinned patients. The small, hyperpigmented lesions tend to become numerous through adulthood.

Conventional treatments of DPN include cryotherapy, curettage, excision, and electrodesiccation. All are notoriously associated with increased risks of hyper- and hypopigmentation in darker skin types, said Dr. El-Attar, who had no financial conflicts of interest to disclose in connection with this study.

This patient—like the others in the study—was distressed by her lesions.

Significant clearance can be seen after treatment with the 532-nm laser. PHOTOS COURTESY DR. AYMAN EL-ATTAR

PHOENIX — A 532-nm diode laser was highly effective at clearing extensive dermatosis papulosis nigra lesions while avoiding the pigmentary complications that are the bane of conventional treatments for this disorder of darker skin, according to the results of a study involving 40 patients with a total of 1,312 lesions.

In the study, patients with Fitzgerald skin types IV-VI were treated with the Iridex 532-nm KTP DioLiteXP laser for extensive lesions of dermatosis papulosis nigra (DPN) that they found distressing and aesthetically unappealing, Dr. Ayman El-Attar said at the annual meeting of the American Academy of Cosmetic Surgery.

Of the 1,312 DPN lesions on the face, neck, and upper torso addressed over the course of three or four sessions, 98% were cleared or significantly improved at follow-up. The other 2% were located close to the eyelid margins, so Dr. El-Attar elected to leave them untreated.

“Using eye shields, you could easily treat those,” however, noted Dr. El-Attar, who is a laser and cosmetic skin surgeon in Somerset, N.J.

For purposes of the study, efficacy and patient satisfaction were assessed 4 weeks after each treatment session and again 6 months after the final treatment. Patient evaluations of their outcome ranged from “satisfied” to “very satisfied.”

The 532-nm DioliteXP laser, a diode-pumped, frequency-doubled Nd:YAG laser, is widely used in office-based dermatology for treatment of facial telangiectasias.

The green light wavelength laser is extremely lightweight, affordable, easy to use, and readily moved between treatment rooms. The small spot size and limited depth of penetration permit the operator to avoid laser-induced purpura, Dr. El-Attar explained.

The 532-nm diode laser enables patients being treated for DPN to go straight back to work with no downtime for recovery. The key to excellent results, Dr. El-Attar stressed, is to treat cautiously, spreading the work over three or four sessions separated by about 4 weeks in patients with numerous lesions.

“The end point of treating these lesions is graying of the lesion. You don't want to go past this end point. Because African Americans and others with darker skin types are very prone to pigmentary changes, we try to be very conservative. That's why we use several sessions. We never go overboard. We always undertreat,” he said.

Depending upon the size and thickness of a lesion, he uses a repetition rate of 5-7 Hz at 10-16 J/cm

Most patients can tolerate the procedure without a topical anesthetic. When needed, Dr. El-Attar applies EMLA cream for about 15 minutes prior to treatment.

The treated lesions immediately turn gray and then become black and exfoliate over the course of a few days to a week. Because patients occasionally have developed mild itching as a reaction to topical antibiotics, Dr. El-Attar generally has patients apply Vaseline or another bland oil-based topical product to treated areas as they heal.

“Occasionally there are footprints: changes in coloration where the lesions were. The easiest treatment for this is tincture of time, but if the patient is in a rush we can do some mild chemical peeling and that takes care of it 100%,” he said in an interview.

Dermatosis papulosis nigra is an extremely common benign cutaneous condition in African Americans and others who have Fitzgerald skin types IV-VI. DPN is believed to have a strong genetic component and is analogous to seborrheic keratoses in lighter-skinned patients. The small, hyperpigmented lesions tend to become numerous through adulthood.

Conventional treatments of DPN include cryotherapy, curettage, excision, and electrodesiccation. All are notoriously associated with increased risks of hyper- and hypopigmentation in darker skin types, said Dr. El-Attar, who had no financial conflicts of interest to disclose in connection with this study.

This patient—like the others in the study—was distressed by her lesions.

Significant clearance can be seen after treatment with the 532-nm laser. PHOTOS COURTESY DR. AYMAN EL-ATTAR

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The Treatment of Melasma: Which Drugs Are Effective? [letter]

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Efficacy of a Natural-Based Bleaching Cream Versus Hydroquinone 4% Bleaching Gel in the Treatment of Hyperpigmentation

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Successful Treatment of Moderate to Severe Melasma With Triple-Combination Cream and Glycolic Acid Peels: A Pilot Study

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Out of the Dark: The Medical Management of Melasma

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