Leonard Feldman, MD

Nearly 48,000 Americans died from overdoses involving opioids in 2018, continuing a national crisis that has led to 446,000 deaths since 1999.¹ Annually, opioids are responsible for more than 500,000 admissions, approximately 1% of all hospitalizations, costing the United States nearly $15 billion.^2,3 Among hospitalized patients, chronic opioid use is associated with increased mortality, severe infectious complications, and higher rates of readmission.⁴ Opioid use disorder (OUD) is a chronic, relapsing medical condition with biopsychosocial origins and significant morbidity and mortality.⁵ Opioid agonist therapy (OAT) with buprenorphine or methadone maintenance, the evidence-based standard of treatment, reduces the mortality rate by half, decreases overdoses and hospital readmissions, and improves retention in care.^6-10

OAT maintenance refers to using buprenorphine or methadone for long-term treatment of OUD rather than for acute treatment of opioid withdrawal. Despite evidence supporting OAT maintenance, clinicians start medications for only 11% to 15% of hospitalized patients with OUD, depending on practice contexts.^11,12 Three significant barriers—stigma, insufficient clinician education, and restrictive regulations—prevent clinicians from starting OAT.¹³ Clinicians who do not have the Drug Enforcement Administration (DEA)–issued DATA-2000 waiver (X-waiver) for outpatient prescribing can order buprenorphine for admitted patients but cannot prescribe it at discharge.¹⁴ In hospitals where they exist, addiction medicine consult services offer primary teams guidance on pharmacotherapy, leading to reduced hospital readmissions and increased engagement in outpatient addiction treatment.^15-17 However, in most hospitals around the country, such specialty services do not exist.¹⁸ In some hospitals without addiction medicine consult services, hospitalists with expertise in OUD have started assisting primary teams in starting OAT, but to our knowledge, no prior studies have described the impact of these interventions on patients or clinician experience with OAT.¹⁹

This quality improvement project aimed to increase the rate at which internal medicine resident teams at Johns Hopkins Hospital (JHH) in Baltimore, Maryland, started hospitalized patients with OUD on buprenorphine maintenance. We hypothesized that resident education and measures to increase the availability of X-waivered physicians would increase the rate of initiating buprenorphine maintenance. We additionally hypothesized that these interventions would increase knowledge about and comfort with buprenorphine across the residency. This represents the first study to examine the effects of clinician education and a team of X-waivered residents and hospitalists who assist in starting buprenorphine maintenance in a hospital without an addiction medicine consult service.

Setting

This study took place from July 2018 to June 2019 at JHH, a large, academic, urban hospital in Baltimore. Prior to the intervention, internal medicine residents at JHH commonly used short courses of buprenorphine to treat withdrawal, but they did not have access to hospital-specific resources to assist with starting maintenance OAT. During the study period, JHH had a Substance Use Disorders team staffed by peer recovery specialists that could be consulted by hospitalists and residents to provide psychosocial support and link admitted patients to treatment after discharge. There were no providers on the team to guide pharmacotherapy or to write discharge buprenorphine prescriptions. The Osler Medical Residency Training Program at JHH has 140 internal medicine residents and 16 combined medicine-pediatrics residents. All residents receive 1 hour of formal education about opioid use disorder annually. In addition, 28 of those 156 residents, those in the Urban Health Primary Care track, spend 1 month on an Addiction Medicine rotation in which they complete the 8-hour training required to receive the X-waiver. Those residents are encouraged to apply for the X-waiver once they obtain a medical license subsidized by a Health Resources & Services Administration (HRSA) grant. Four internal medicine attending physicians on teaching services and one resident had X-waivers prior to the intervention.

Intervention

In November 2018, we administered a survey to residents to identify barriers to starting buprenorphine maintenance and to measure knowledge and confidence with using buprenorphine for OUD (Appendix Figure 1 and Figure 2). We focused on buprenorphine because providers at JHH were familiar with this medication and because Baltimore has widespread access to buprenorphine, with more than 490 local buprenorphine providers.²⁰ Five residents piloted the survey and provided feedback. We then administered the survey to all internal medicine and medicine-pediatrics residents. Based on the results, we developed a targeted educational conference and also created the Buprenorphine Bridge Team (BBT).

In January 2019, we presented the educational conference for residents devoted to the use of buprenorphine for OUD and introduced the BBT. The conference started with a patient testimonial and included peer recovery specialists, pharmacists, nurses, and social workers. We summarized the evidence for buprenorphine and offered a practical guide to start treatment in a one-page protocol. This protocol included guidance on selecting patients, shared decision-making around OUD treatment, avoiding precipitated withdrawal, dosing buprenorphine, and establishing follow-up (Appendix Figure 3). We asked for input on this protocol from nursing leadership, social work teams, and peer recovery specialists. Dosing was adapted from the Guidelines from the American Society of Addiction Medicine, with expert input from physicians from the Addiction Medicine Consult service at Johns Hopkins Bayview Medical Center, also in Baltimore.⁵ We instructed residents to obtain discharge buprenorphine prescriptions from an X-waivered physician on their team or from the newly established BBT. We asked resident teams to set up a postdischarge appointment for patients with an X-waivered provider, either in a community practice or at the JHH After Care Clinic, a transitional care clinic for discharged patients.²¹

The BBT is a resident-led group of X-waivered JHH residents and hospitalists who volunteer to write discharge buprenorphine prescriptions for patients. The BBT serves to ensure primary teams have access to an X-waivered prescriber. It is not a consult service. We asked primary teams to contact the BBT after initiating buprenorphine and after securing a follow-up appointment. In response to each request, a member of the BBT reviews the patient chart, confirms the follow-up plan, writes a prescription for buprenorphine along with intranasal naloxone, and leaves a brief note. During the 6-month postintervention period, the team consisted of three residents and three hospitalist attendings. Each week, two members (residents or attendings) staffed the team Monday to Friday, 8 am to 5 pm. Most weeks were staffed by two residents. One resident provided services after hours and during weekends. Resident team members ensured that the buprenorphine plan was discussed with the primary team’s attending. For dosing questions beyond the BBT’s scope of knowledge, a member of the BBT relayed questions to physicians from the Addiction Medicine Consult team at Johns Hopkins Bayview Medical Center.

In May 2019, 5 months after the education session and implementation of the BBT, we administered a follow-up survey.

Outcomes

The primary outcome was the percent of inpatients eligible to start OAT who were discharged on buprenorphine maintenance. We obtained data from the electronic medical record. The denominator consisted of patients with OUD not on buprenorphine or methadone maintenance on admission. We identified patients with OUD by an opioid-related International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code or by a standing or as-needed order for buprenorphine or methadone during hospitalization.²² We reviewed admission and discharge documentation to identify patients with OUD who were not in active treatment with buprenorphine or methadone maintenance.

As a secondary outcome, we measured engagement in OUD treatment after discharge by calculating the proportion of patients started on buprenorphine who filled a buprenorphine prescription within 30 days after discharge. We chose 30 days based on the National Committee for Quality Assurance’s Healthcare Effectiveness Data and Information Set (HEDIS) measure for engagement of treatment for alcohol and other drugs.²³ We obtained the data from the Chesapeake Regional Information System for our Patients (CRISP) Prescription Drug Monitoring Program, which monitors all prescriptions for controlled substances dispensed in Maryland and five neighboring states. As a balancing measure, we counted patients newly started on methadone maintenance for OUD before and after the intervention. Additional secondary process outcomes included frequency of BBT requests, the volume of buprenorphine prescriptions written by the team, and time required to complete a BBT request.

Clinician-level outcomes, measured with electronically administered pre- and postintervention surveys to residents, included knowledge about and comfort with buprenorphine. Of the 16 questions in the pre- and postimplementation surveys, we analyzed the 6 questions concerning knowledge and comfort that remained identical in the pre- and postintervention surveys and used 5-point Likert scale responses. As an incentive, we randomly distributed three $50 gift cards to survey completers.

Analysis

We used an interrupted time series analysis to evaluate the association between the intervention bundle and a change in the rate that medical teams started patients with OUD on buprenorphine maintenance. This approach allowed us to control for preintervention trends. To evaluate the impact of our interventions, our pre- and postintervention periods include the same residents during the 2018-2019 academic year. Both periods consisted of twelve 2-week intervals (preintervention: July 26, 2019, to January 9, 2019; postintervention: January 10, 2019, to June 26, 2019).

To evaluate for changes in engagement in OUD treatment after discharge, we used two-sample t tests. To evaluate for changes in resident-reported comfort and knowledge with initiating buprenorphine maintenance, we used Wilcoxon rank sum tests for survey data and Wilcoxon signed rank tests for paired data. All analyses employed two-sided P values with statistical significance evaluated at the .05 alpha level. We analyzed data using R version 3.6.3 (Foundation for Statistical Computing). The Institutional Review Board at JHH reviewed and approved the study protocol as a quality improvement project (IRB00193365).

During the 24-week preintervention period, internal medicine resident teams started 30 out of 305 eligible patients (10%) on buprenorphine maintenance vs 64 out of 270 eligible patients (24%) during the 24-week postintervention period. Our interrupted time series analysis showed a significant increase in the percent of eligible patients started on buprenorphine maintenance (expected number of patients started postintervention, 27; actual, 64; absolute increase in percent, 14.4%; 95% CI, 3.6%-25.3%; P = .017) (Figure). There was no significant trend during the preintervention period and no significant trend during the postintervention period.

Before the intervention, 13 of the 30 patients (40%) newly started on buprenorphine maintenance during their admission filled a follow-up buprenorphine prescription within 30 days of discharge. After the intervention, 31 of 64 patients (46%) filled a buprenorphine prescription within 30 days (P = .612). Two patients were started on methadone maintenance, one prior to and one after the intervention.

During the 6-month postintervention period, the BBT received 75 requests and wrote 70 prescriptions for buprenorphine. The median time required to complete a BBT request was 15 minutes (minimum, 5 minutes; maximum, 60 minutes).

Of 156 internal medicine and medicine-pediatrics residents, 89 residents (57%) completed the baseline survey and 66 residents (42%) completed the follow-up survey. Forty residents completed both surveys. After the intervention, residents were significantly more likely to feel comfortable dosing buprenorphine (P < .0001) and counseling patients about its use (P = .0237) and were more likely to report ease of establishing follow-up (P < .0001). Self-reported knowledge about preventing precipitated withdrawal increased significantly (P = .0191), as did knowledge about the effectiveness of buprenorphine (P = .0003) independent of formal drug counseling (P = .0066) (Table). Paired survey data also found statistically significant results for all questions except those about preventing precipitated withdrawal and efficacy. For the latter, respondents who completed both surveys were more knowledgeable before the intervention than the overall group that completed the baseline survey (Appendix Table).

This study shows how a resident-led quality improvement project comprising clinician education and implementation of a novel BBT was associated with an increased rate of starting buprenorphine maintenance in hospitalized patients with OUD and improved resident knowledge about and comfort with buprenorphine. To our knowledge, this is the first study demonstrating how education and a team of X-waivered generalists can help primary teams initiate and discharge patients on buprenorphine maintenance in a hospital without an addiction medicine consult service.

Prior to the intervention, resident internal medicine teams at JHH started 10% of hospitalized patients with OUD on buprenorphine maintenance, consistent with prior studies showing rates of 11% to 15% for initiating OAT for hospitalized patients.^11,12 After the intervention, the rate of initiating buprenorphine maintenance more than doubled, rising to 24% of eligible patients. Resident internal medicine teams at JHH started buprenorphine maintenance for 37 more patients over the 24-week postintervention period than would have been predicted prior to the intervention, or an additional three patients every 2 weeks.

Between 40% and 46% of hospitalized patients newly started on buprenorphine maintenance filled an outpatient buprenorphine prescription within 30 days of discharge. We are not aware of comparative data for 30-day follow-up for hospitalized patients newly started on buprenorphine maintenance. Data from other contexts show 5% to 10% of veterans were engaged in addiction treatment 30 days after initiation from inpatient or outpatient encounters. An analysis of an academic medical center in Oregon found engagement with an addiction medicine consult service increased after hospital engagement for patients with any substance use disorder from 23% to 39% using the 34-day HEDIS measure for engagement.^17,24,25

The BBT required approximately 15 minutes per request and wrote an average of three prescriptions per week, demonstrating the feasibility of this approach and the high demand for this service. One strength of our approach is that residents gained experience starting buprenorphine independently using the aforementioned protocol instead of deferring to a full consult service. It is likely that this resident engagement in initiating longitudinal OUD care contributed to the success of this initiative, as did existing resident familiarity with using buprenorphine for opioid withdrawal.

This approach to resident education—promoting direct, first-person experience with medications in a clinical context—aligns with recommendations from a recent review about substance use disorder education for health professionals.²⁶ Our interventions increased resident knowledge and comfort with buprenorphine, consistent with prior studies showing increased resident confidence in management of substance use disorders after curricular innovations.^24,25

A few contextual features were essential for this project’s viability. Maryland allows American medical graduates to obtain a medical license after 1 year of postgraduate training. This allowed three residents to obtain X-waivers. These residents had access to HRSA funding to subsidize the expenses of applying for state licensure and DEA registration. BBT members volunteered their time while working on other services. Last, we were able to take advantage of buprenorphine-providing clinics in Baltimore, including the JHH After Care Clinic, to accept patients for follow-up appointments after discharge.

Limitations

The BBT required motivated clinicians willing to volunteer for additional clinical responsibilities during inpatient rotations and supportive faculty and residency leadership. Attending physicians, nurse practitioners, or physician assistants could staff a similar BBT in hospitals without residents or in hospitals where residents cannot obtain DEA registration. Crucially, other hospitals may not have access to practices with X-waivered physicians for outpatient follow-up. A recent study found X-waivered primary care physicians were less likely to be affiliated with hospital health systems. Other studies have shown limitations in access to buprenorphine at the county level based on geography and racial/ethnic segregation.^27-29

Most patients hospitalized with OUD did not have ICD-10 codes associated with OUD. We addressed this by assuming patients had OUD if buprenorphine or methadone was ordered during their hospitalization, even if the medication was never administered. This may have overcounted patients prescribed these medications for indications other than OUD, and it may have undercounted patients with OUD for whom buprenorphine or methadone were never considered. The opioid withdrawal order set at JHH automatically offers an option to use buprenorphine to treat withdrawal. Patients with OUD for whom buprenorphine or methadone were never ordered likely did not experience withdrawal or were in withdrawal so mild that it escaped the attention of the team, which limits the generalizability of our intervention.

We identified several limitations to the internal validity of our study. First, we used a before-and-after study design without a control group. We could not ethically withhold access to evidence-based, mortality-reducing medications from patients. Without a control group, we cannot rule out the possibility that underlying temporal trends made residents more likely to start buprenorphine maintenance independent of our intervention. We attempted to control for unmeasured confounders by using an interrupted time series analysis to control for preintervention trends, comparing the same group of residents before and after our interventions, and selecting an intervention period during which residents were given only educational sessions and materials provided by our team. Our results may be biased by clustered data because certain residents may have been more likely to initiate buprenorphine, but these effects are likely marginal because resident schedules are balanced between outpatient and inpatient rotations during each 6-month period.

Finally, this project focused on buprenorphine, not on other medications for OUD, including methadone or naltrexone, or nonpharmacologic treatments for OUD.

Since the start of the BBT in January 2019, five additional PGY-2 residents obtained their medical licenses and X-waivers. These residents, with the support of two attending hospitalists, led the BBT and coordinated education sessions that were incorporated into the curriculum during the 2019-2020 academic year. These educational sessions will continue indefinitely. In 2020, JHH started an Addiction Medicine Consult Service staffed by physicians, NPs, and a pharmacist. The BBT continues to operate in conjunction with this service.

We found substantial variability in the rate of buprenorphine maintenance initiation despite our interventions. This is an area for future improvement. In a free-response prompt in our follow-up survey, residents requested additional education sessions and an order set to assist with initiation of buprenorphine. To address these gaps, three educational sessions were added, one of which included education on starting methadone maintenance therapy. We also added a new order set for starting buprenorphine maintenance. We hypothesize that these interventions will improve consistency.

In order for a similar program to be disseminated to other institutions, educational initiatives and a team of dedicated X-waivered prescribers are key. Materials to assist with this process are available in the Appendix.

This study shows how a resident-led intervention comprising clinician education and a team of X-waivered generalists was associated with improved treatment of OUD for hospitalized patients. We encourage residents and all clinicians at other hospitals without addiction medicine consult services to design, implement, and study similar interventions that directly increase the use of buprenorphine or methadone maintenance to treat OUD.

Preliminary results from this project were presented at the AMERSA National Conference on November 7, 2019.

Nearly 48,000 Americans died from overdoses involving opioids in 2018, continuing a national crisis that has led to 446,000 deaths since 1999.¹ Annually, opioids are responsible for more than 500,000 admissions, approximately 1% of all hospitalizations, costing the United States nearly $15 billion.^2,3 Among hospitalized patients, chronic opioid use is associated with increased mortality, severe infectious complications, and higher rates of readmission.⁴ Opioid use disorder (OUD) is a chronic, relapsing medical condition with biopsychosocial origins and significant morbidity and mortality.⁵ Opioid agonist therapy (OAT) with buprenorphine or methadone maintenance, the evidence-based standard of treatment, reduces the mortality rate by half, decreases overdoses and hospital readmissions, and improves retention in care.^6-10

OAT maintenance refers to using buprenorphine or methadone for long-term treatment of OUD rather than for acute treatment of opioid withdrawal. Despite evidence supporting OAT maintenance, clinicians start medications for only 11% to 15% of hospitalized patients with OUD, depending on practice contexts.^11,12 Three significant barriers—stigma, insufficient clinician education, and restrictive regulations—prevent clinicians from starting OAT.¹³ Clinicians who do not have the Drug Enforcement Administration (DEA)–issued DATA-2000 waiver (X-waiver) for outpatient prescribing can order buprenorphine for admitted patients but cannot prescribe it at discharge.¹⁴ In hospitals where they exist, addiction medicine consult services offer primary teams guidance on pharmacotherapy, leading to reduced hospital readmissions and increased engagement in outpatient addiction treatment.^15-17 However, in most hospitals around the country, such specialty services do not exist.¹⁸ In some hospitals without addiction medicine consult services, hospitalists with expertise in OUD have started assisting primary teams in starting OAT, but to our knowledge, no prior studies have described the impact of these interventions on patients or clinician experience with OAT.¹⁹

This quality improvement project aimed to increase the rate at which internal medicine resident teams at Johns Hopkins Hospital (JHH) in Baltimore, Maryland, started hospitalized patients with OUD on buprenorphine maintenance. We hypothesized that resident education and measures to increase the availability of X-waivered physicians would increase the rate of initiating buprenorphine maintenance. We additionally hypothesized that these interventions would increase knowledge about and comfort with buprenorphine across the residency. This represents the first study to examine the effects of clinician education and a team of X-waivered residents and hospitalists who assist in starting buprenorphine maintenance in a hospital without an addiction medicine consult service.

Setting

This study took place from July 2018 to June 2019 at JHH, a large, academic, urban hospital in Baltimore. Prior to the intervention, internal medicine residents at JHH commonly used short courses of buprenorphine to treat withdrawal, but they did not have access to hospital-specific resources to assist with starting maintenance OAT. During the study period, JHH had a Substance Use Disorders team staffed by peer recovery specialists that could be consulted by hospitalists and residents to provide psychosocial support and link admitted patients to treatment after discharge. There were no providers on the team to guide pharmacotherapy or to write discharge buprenorphine prescriptions. The Osler Medical Residency Training Program at JHH has 140 internal medicine residents and 16 combined medicine-pediatrics residents. All residents receive 1 hour of formal education about opioid use disorder annually. In addition, 28 of those 156 residents, those in the Urban Health Primary Care track, spend 1 month on an Addiction Medicine rotation in which they complete the 8-hour training required to receive the X-waiver. Those residents are encouraged to apply for the X-waiver once they obtain a medical license subsidized by a Health Resources & Services Administration (HRSA) grant. Four internal medicine attending physicians on teaching services and one resident had X-waivers prior to the intervention.

Intervention

In November 2018, we administered a survey to residents to identify barriers to starting buprenorphine maintenance and to measure knowledge and confidence with using buprenorphine for OUD (Appendix Figure 1 and Figure 2). We focused on buprenorphine because providers at JHH were familiar with this medication and because Baltimore has widespread access to buprenorphine, with more than 490 local buprenorphine providers.²⁰ Five residents piloted the survey and provided feedback. We then administered the survey to all internal medicine and medicine-pediatrics residents. Based on the results, we developed a targeted educational conference and also created the Buprenorphine Bridge Team (BBT).

In January 2019, we presented the educational conference for residents devoted to the use of buprenorphine for OUD and introduced the BBT. The conference started with a patient testimonial and included peer recovery specialists, pharmacists, nurses, and social workers. We summarized the evidence for buprenorphine and offered a practical guide to start treatment in a one-page protocol. This protocol included guidance on selecting patients, shared decision-making around OUD treatment, avoiding precipitated withdrawal, dosing buprenorphine, and establishing follow-up (Appendix Figure 3). We asked for input on this protocol from nursing leadership, social work teams, and peer recovery specialists. Dosing was adapted from the Guidelines from the American Society of Addiction Medicine, with expert input from physicians from the Addiction Medicine Consult service at Johns Hopkins Bayview Medical Center, also in Baltimore.⁵ We instructed residents to obtain discharge buprenorphine prescriptions from an X-waivered physician on their team or from the newly established BBT. We asked resident teams to set up a postdischarge appointment for patients with an X-waivered provider, either in a community practice or at the JHH After Care Clinic, a transitional care clinic for discharged patients.²¹

The BBT is a resident-led group of X-waivered JHH residents and hospitalists who volunteer to write discharge buprenorphine prescriptions for patients. The BBT serves to ensure primary teams have access to an X-waivered prescriber. It is not a consult service. We asked primary teams to contact the BBT after initiating buprenorphine and after securing a follow-up appointment. In response to each request, a member of the BBT reviews the patient chart, confirms the follow-up plan, writes a prescription for buprenorphine along with intranasal naloxone, and leaves a brief note. During the 6-month postintervention period, the team consisted of three residents and three hospitalist attendings. Each week, two members (residents or attendings) staffed the team Monday to Friday, 8 am to 5 pm. Most weeks were staffed by two residents. One resident provided services after hours and during weekends. Resident team members ensured that the buprenorphine plan was discussed with the primary team’s attending. For dosing questions beyond the BBT’s scope of knowledge, a member of the BBT relayed questions to physicians from the Addiction Medicine Consult team at Johns Hopkins Bayview Medical Center.

In May 2019, 5 months after the education session and implementation of the BBT, we administered a follow-up survey.

Outcomes

The primary outcome was the percent of inpatients eligible to start OAT who were discharged on buprenorphine maintenance. We obtained data from the electronic medical record. The denominator consisted of patients with OUD not on buprenorphine or methadone maintenance on admission. We identified patients with OUD by an opioid-related International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code or by a standing or as-needed order for buprenorphine or methadone during hospitalization.²² We reviewed admission and discharge documentation to identify patients with OUD who were not in active treatment with buprenorphine or methadone maintenance.

As a secondary outcome, we measured engagement in OUD treatment after discharge by calculating the proportion of patients started on buprenorphine who filled a buprenorphine prescription within 30 days after discharge. We chose 30 days based on the National Committee for Quality Assurance’s Healthcare Effectiveness Data and Information Set (HEDIS) measure for engagement of treatment for alcohol and other drugs.²³ We obtained the data from the Chesapeake Regional Information System for our Patients (CRISP) Prescription Drug Monitoring Program, which monitors all prescriptions for controlled substances dispensed in Maryland and five neighboring states. As a balancing measure, we counted patients newly started on methadone maintenance for OUD before and after the intervention. Additional secondary process outcomes included frequency of BBT requests, the volume of buprenorphine prescriptions written by the team, and time required to complete a BBT request.

Clinician-level outcomes, measured with electronically administered pre- and postintervention surveys to residents, included knowledge about and comfort with buprenorphine. Of the 16 questions in the pre- and postimplementation surveys, we analyzed the 6 questions concerning knowledge and comfort that remained identical in the pre- and postintervention surveys and used 5-point Likert scale responses. As an incentive, we randomly distributed three $50 gift cards to survey completers.

Analysis

We used an interrupted time series analysis to evaluate the association between the intervention bundle and a change in the rate that medical teams started patients with OUD on buprenorphine maintenance. This approach allowed us to control for preintervention trends. To evaluate the impact of our interventions, our pre- and postintervention periods include the same residents during the 2018-2019 academic year. Both periods consisted of twelve 2-week intervals (preintervention: July 26, 2019, to January 9, 2019; postintervention: January 10, 2019, to June 26, 2019).

To evaluate for changes in engagement in OUD treatment after discharge, we used two-sample t tests. To evaluate for changes in resident-reported comfort and knowledge with initiating buprenorphine maintenance, we used Wilcoxon rank sum tests for survey data and Wilcoxon signed rank tests for paired data. All analyses employed two-sided P values with statistical significance evaluated at the .05 alpha level. We analyzed data using R version 3.6.3 (Foundation for Statistical Computing). The Institutional Review Board at JHH reviewed and approved the study protocol as a quality improvement project (IRB00193365).

During the 24-week preintervention period, internal medicine resident teams started 30 out of 305 eligible patients (10%) on buprenorphine maintenance vs 64 out of 270 eligible patients (24%) during the 24-week postintervention period. Our interrupted time series analysis showed a significant increase in the percent of eligible patients started on buprenorphine maintenance (expected number of patients started postintervention, 27; actual, 64; absolute increase in percent, 14.4%; 95% CI, 3.6%-25.3%; P = .017) (Figure). There was no significant trend during the preintervention period and no significant trend during the postintervention period.

Before the intervention, 13 of the 30 patients (40%) newly started on buprenorphine maintenance during their admission filled a follow-up buprenorphine prescription within 30 days of discharge. After the intervention, 31 of 64 patients (46%) filled a buprenorphine prescription within 30 days (P = .612). Two patients were started on methadone maintenance, one prior to and one after the intervention.

During the 6-month postintervention period, the BBT received 75 requests and wrote 70 prescriptions for buprenorphine. The median time required to complete a BBT request was 15 minutes (minimum, 5 minutes; maximum, 60 minutes).

Of 156 internal medicine and medicine-pediatrics residents, 89 residents (57%) completed the baseline survey and 66 residents (42%) completed the follow-up survey. Forty residents completed both surveys. After the intervention, residents were significantly more likely to feel comfortable dosing buprenorphine (P < .0001) and counseling patients about its use (P = .0237) and were more likely to report ease of establishing follow-up (P < .0001). Self-reported knowledge about preventing precipitated withdrawal increased significantly (P = .0191), as did knowledge about the effectiveness of buprenorphine (P = .0003) independent of formal drug counseling (P = .0066) (Table). Paired survey data also found statistically significant results for all questions except those about preventing precipitated withdrawal and efficacy. For the latter, respondents who completed both surveys were more knowledgeable before the intervention than the overall group that completed the baseline survey (Appendix Table).

This study shows how a resident-led quality improvement project comprising clinician education and implementation of a novel BBT was associated with an increased rate of starting buprenorphine maintenance in hospitalized patients with OUD and improved resident knowledge about and comfort with buprenorphine. To our knowledge, this is the first study demonstrating how education and a team of X-waivered generalists can help primary teams initiate and discharge patients on buprenorphine maintenance in a hospital without an addiction medicine consult service.

Prior to the intervention, resident internal medicine teams at JHH started 10% of hospitalized patients with OUD on buprenorphine maintenance, consistent with prior studies showing rates of 11% to 15% for initiating OAT for hospitalized patients.^11,12 After the intervention, the rate of initiating buprenorphine maintenance more than doubled, rising to 24% of eligible patients. Resident internal medicine teams at JHH started buprenorphine maintenance for 37 more patients over the 24-week postintervention period than would have been predicted prior to the intervention, or an additional three patients every 2 weeks.

Between 40% and 46% of hospitalized patients newly started on buprenorphine maintenance filled an outpatient buprenorphine prescription within 30 days of discharge. We are not aware of comparative data for 30-day follow-up for hospitalized patients newly started on buprenorphine maintenance. Data from other contexts show 5% to 10% of veterans were engaged in addiction treatment 30 days after initiation from inpatient or outpatient encounters. An analysis of an academic medical center in Oregon found engagement with an addiction medicine consult service increased after hospital engagement for patients with any substance use disorder from 23% to 39% using the 34-day HEDIS measure for engagement.^17,24,25

The BBT required approximately 15 minutes per request and wrote an average of three prescriptions per week, demonstrating the feasibility of this approach and the high demand for this service. One strength of our approach is that residents gained experience starting buprenorphine independently using the aforementioned protocol instead of deferring to a full consult service. It is likely that this resident engagement in initiating longitudinal OUD care contributed to the success of this initiative, as did existing resident familiarity with using buprenorphine for opioid withdrawal.

This approach to resident education—promoting direct, first-person experience with medications in a clinical context—aligns with recommendations from a recent review about substance use disorder education for health professionals.²⁶ Our interventions increased resident knowledge and comfort with buprenorphine, consistent with prior studies showing increased resident confidence in management of substance use disorders after curricular innovations.^24,25

A few contextual features were essential for this project’s viability. Maryland allows American medical graduates to obtain a medical license after 1 year of postgraduate training. This allowed three residents to obtain X-waivers. These residents had access to HRSA funding to subsidize the expenses of applying for state licensure and DEA registration. BBT members volunteered their time while working on other services. Last, we were able to take advantage of buprenorphine-providing clinics in Baltimore, including the JHH After Care Clinic, to accept patients for follow-up appointments after discharge.

Limitations

The BBT required motivated clinicians willing to volunteer for additional clinical responsibilities during inpatient rotations and supportive faculty and residency leadership. Attending physicians, nurse practitioners, or physician assistants could staff a similar BBT in hospitals without residents or in hospitals where residents cannot obtain DEA registration. Crucially, other hospitals may not have access to practices with X-waivered physicians for outpatient follow-up. A recent study found X-waivered primary care physicians were less likely to be affiliated with hospital health systems. Other studies have shown limitations in access to buprenorphine at the county level based on geography and racial/ethnic segregation.^27-29

Most patients hospitalized with OUD did not have ICD-10 codes associated with OUD. We addressed this by assuming patients had OUD if buprenorphine or methadone was ordered during their hospitalization, even if the medication was never administered. This may have overcounted patients prescribed these medications for indications other than OUD, and it may have undercounted patients with OUD for whom buprenorphine or methadone were never considered. The opioid withdrawal order set at JHH automatically offers an option to use buprenorphine to treat withdrawal. Patients with OUD for whom buprenorphine or methadone were never ordered likely did not experience withdrawal or were in withdrawal so mild that it escaped the attention of the team, which limits the generalizability of our intervention.

We identified several limitations to the internal validity of our study. First, we used a before-and-after study design without a control group. We could not ethically withhold access to evidence-based, mortality-reducing medications from patients. Without a control group, we cannot rule out the possibility that underlying temporal trends made residents more likely to start buprenorphine maintenance independent of our intervention. We attempted to control for unmeasured confounders by using an interrupted time series analysis to control for preintervention trends, comparing the same group of residents before and after our interventions, and selecting an intervention period during which residents were given only educational sessions and materials provided by our team. Our results may be biased by clustered data because certain residents may have been more likely to initiate buprenorphine, but these effects are likely marginal because resident schedules are balanced between outpatient and inpatient rotations during each 6-month period.

Finally, this project focused on buprenorphine, not on other medications for OUD, including methadone or naltrexone, or nonpharmacologic treatments for OUD.

Since the start of the BBT in January 2019, five additional PGY-2 residents obtained their medical licenses and X-waivers. These residents, with the support of two attending hospitalists, led the BBT and coordinated education sessions that were incorporated into the curriculum during the 2019-2020 academic year. These educational sessions will continue indefinitely. In 2020, JHH started an Addiction Medicine Consult Service staffed by physicians, NPs, and a pharmacist. The BBT continues to operate in conjunction with this service.

We found substantial variability in the rate of buprenorphine maintenance initiation despite our interventions. This is an area for future improvement. In a free-response prompt in our follow-up survey, residents requested additional education sessions and an order set to assist with initiation of buprenorphine. To address these gaps, three educational sessions were added, one of which included education on starting methadone maintenance therapy. We also added a new order set for starting buprenorphine maintenance. We hypothesize that these interventions will improve consistency.

In order for a similar program to be disseminated to other institutions, educational initiatives and a team of dedicated X-waivered prescribers are key. Materials to assist with this process are available in the Appendix.

This study shows how a resident-led intervention comprising clinician education and a team of X-waivered generalists was associated with improved treatment of OUD for hospitalized patients. We encourage residents and all clinicians at other hospitals without addiction medicine consult services to design, implement, and study similar interventions that directly increase the use of buprenorphine or methadone maintenance to treat OUD.

Preliminary results from this project were presented at the AMERSA National Conference on November 7, 2019.

Nearly 48,000 Americans died from overdoses involving opioids in 2018, continuing a national crisis that has led to 446,000 deaths since 1999.¹ Annually, opioids are responsible for more than 500,000 admissions, approximately 1% of all hospitalizations, costing the United States nearly $15 billion.^2,3 Among hospitalized patients, chronic opioid use is associated with increased mortality, severe infectious complications, and higher rates of readmission.⁴ Opioid use disorder (OUD) is a chronic, relapsing medical condition with biopsychosocial origins and significant morbidity and mortality.⁵ Opioid agonist therapy (OAT) with buprenorphine or methadone maintenance, the evidence-based standard of treatment, reduces the mortality rate by half, decreases overdoses and hospital readmissions, and improves retention in care.^6-10

OAT maintenance refers to using buprenorphine or methadone for long-term treatment of OUD rather than for acute treatment of opioid withdrawal. Despite evidence supporting OAT maintenance, clinicians start medications for only 11% to 15% of hospitalized patients with OUD, depending on practice contexts.^11,12 Three significant barriers—stigma, insufficient clinician education, and restrictive regulations—prevent clinicians from starting OAT.¹³ Clinicians who do not have the Drug Enforcement Administration (DEA)–issued DATA-2000 waiver (X-waiver) for outpatient prescribing can order buprenorphine for admitted patients but cannot prescribe it at discharge.¹⁴ In hospitals where they exist, addiction medicine consult services offer primary teams guidance on pharmacotherapy, leading to reduced hospital readmissions and increased engagement in outpatient addiction treatment.^15-17 However, in most hospitals around the country, such specialty services do not exist.¹⁸ In some hospitals without addiction medicine consult services, hospitalists with expertise in OUD have started assisting primary teams in starting OAT, but to our knowledge, no prior studies have described the impact of these interventions on patients or clinician experience with OAT.¹⁹

This quality improvement project aimed to increase the rate at which internal medicine resident teams at Johns Hopkins Hospital (JHH) in Baltimore, Maryland, started hospitalized patients with OUD on buprenorphine maintenance. We hypothesized that resident education and measures to increase the availability of X-waivered physicians would increase the rate of initiating buprenorphine maintenance. We additionally hypothesized that these interventions would increase knowledge about and comfort with buprenorphine across the residency. This represents the first study to examine the effects of clinician education and a team of X-waivered residents and hospitalists who assist in starting buprenorphine maintenance in a hospital without an addiction medicine consult service.

Setting

This study took place from July 2018 to June 2019 at JHH, a large, academic, urban hospital in Baltimore. Prior to the intervention, internal medicine residents at JHH commonly used short courses of buprenorphine to treat withdrawal, but they did not have access to hospital-specific resources to assist with starting maintenance OAT. During the study period, JHH had a Substance Use Disorders team staffed by peer recovery specialists that could be consulted by hospitalists and residents to provide psychosocial support and link admitted patients to treatment after discharge. There were no providers on the team to guide pharmacotherapy or to write discharge buprenorphine prescriptions. The Osler Medical Residency Training Program at JHH has 140 internal medicine residents and 16 combined medicine-pediatrics residents. All residents receive 1 hour of formal education about opioid use disorder annually. In addition, 28 of those 156 residents, those in the Urban Health Primary Care track, spend 1 month on an Addiction Medicine rotation in which they complete the 8-hour training required to receive the X-waiver. Those residents are encouraged to apply for the X-waiver once they obtain a medical license subsidized by a Health Resources & Services Administration (HRSA) grant. Four internal medicine attending physicians on teaching services and one resident had X-waivers prior to the intervention.

Intervention

In November 2018, we administered a survey to residents to identify barriers to starting buprenorphine maintenance and to measure knowledge and confidence with using buprenorphine for OUD (Appendix Figure 1 and Figure 2). We focused on buprenorphine because providers at JHH were familiar with this medication and because Baltimore has widespread access to buprenorphine, with more than 490 local buprenorphine providers.²⁰ Five residents piloted the survey and provided feedback. We then administered the survey to all internal medicine and medicine-pediatrics residents. Based on the results, we developed a targeted educational conference and also created the Buprenorphine Bridge Team (BBT).

In January 2019, we presented the educational conference for residents devoted to the use of buprenorphine for OUD and introduced the BBT. The conference started with a patient testimonial and included peer recovery specialists, pharmacists, nurses, and social workers. We summarized the evidence for buprenorphine and offered a practical guide to start treatment in a one-page protocol. This protocol included guidance on selecting patients, shared decision-making around OUD treatment, avoiding precipitated withdrawal, dosing buprenorphine, and establishing follow-up (Appendix Figure 3). We asked for input on this protocol from nursing leadership, social work teams, and peer recovery specialists. Dosing was adapted from the Guidelines from the American Society of Addiction Medicine, with expert input from physicians from the Addiction Medicine Consult service at Johns Hopkins Bayview Medical Center, also in Baltimore.⁵ We instructed residents to obtain discharge buprenorphine prescriptions from an X-waivered physician on their team or from the newly established BBT. We asked resident teams to set up a postdischarge appointment for patients with an X-waivered provider, either in a community practice or at the JHH After Care Clinic, a transitional care clinic for discharged patients.²¹

The BBT is a resident-led group of X-waivered JHH residents and hospitalists who volunteer to write discharge buprenorphine prescriptions for patients. The BBT serves to ensure primary teams have access to an X-waivered prescriber. It is not a consult service. We asked primary teams to contact the BBT after initiating buprenorphine and after securing a follow-up appointment. In response to each request, a member of the BBT reviews the patient chart, confirms the follow-up plan, writes a prescription for buprenorphine along with intranasal naloxone, and leaves a brief note. During the 6-month postintervention period, the team consisted of three residents and three hospitalist attendings. Each week, two members (residents or attendings) staffed the team Monday to Friday, 8 am to 5 pm. Most weeks were staffed by two residents. One resident provided services after hours and during weekends. Resident team members ensured that the buprenorphine plan was discussed with the primary team’s attending. For dosing questions beyond the BBT’s scope of knowledge, a member of the BBT relayed questions to physicians from the Addiction Medicine Consult team at Johns Hopkins Bayview Medical Center.

In May 2019, 5 months after the education session and implementation of the BBT, we administered a follow-up survey.

Outcomes

The primary outcome was the percent of inpatients eligible to start OAT who were discharged on buprenorphine maintenance. We obtained data from the electronic medical record. The denominator consisted of patients with OUD not on buprenorphine or methadone maintenance on admission. We identified patients with OUD by an opioid-related International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code or by a standing or as-needed order for buprenorphine or methadone during hospitalization.²² We reviewed admission and discharge documentation to identify patients with OUD who were not in active treatment with buprenorphine or methadone maintenance.

As a secondary outcome, we measured engagement in OUD treatment after discharge by calculating the proportion of patients started on buprenorphine who filled a buprenorphine prescription within 30 days after discharge. We chose 30 days based on the National Committee for Quality Assurance’s Healthcare Effectiveness Data and Information Set (HEDIS) measure for engagement of treatment for alcohol and other drugs.²³ We obtained the data from the Chesapeake Regional Information System for our Patients (CRISP) Prescription Drug Monitoring Program, which monitors all prescriptions for controlled substances dispensed in Maryland and five neighboring states. As a balancing measure, we counted patients newly started on methadone maintenance for OUD before and after the intervention. Additional secondary process outcomes included frequency of BBT requests, the volume of buprenorphine prescriptions written by the team, and time required to complete a BBT request.

Clinician-level outcomes, measured with electronically administered pre- and postintervention surveys to residents, included knowledge about and comfort with buprenorphine. Of the 16 questions in the pre- and postimplementation surveys, we analyzed the 6 questions concerning knowledge and comfort that remained identical in the pre- and postintervention surveys and used 5-point Likert scale responses. As an incentive, we randomly distributed three $50 gift cards to survey completers.

Analysis

We used an interrupted time series analysis to evaluate the association between the intervention bundle and a change in the rate that medical teams started patients with OUD on buprenorphine maintenance. This approach allowed us to control for preintervention trends. To evaluate the impact of our interventions, our pre- and postintervention periods include the same residents during the 2018-2019 academic year. Both periods consisted of twelve 2-week intervals (preintervention: July 26, 2019, to January 9, 2019; postintervention: January 10, 2019, to June 26, 2019).

To evaluate for changes in engagement in OUD treatment after discharge, we used two-sample t tests. To evaluate for changes in resident-reported comfort and knowledge with initiating buprenorphine maintenance, we used Wilcoxon rank sum tests for survey data and Wilcoxon signed rank tests for paired data. All analyses employed two-sided P values with statistical significance evaluated at the .05 alpha level. We analyzed data using R version 3.6.3 (Foundation for Statistical Computing). The Institutional Review Board at JHH reviewed and approved the study protocol as a quality improvement project (IRB00193365).

During the 24-week preintervention period, internal medicine resident teams started 30 out of 305 eligible patients (10%) on buprenorphine maintenance vs 64 out of 270 eligible patients (24%) during the 24-week postintervention period. Our interrupted time series analysis showed a significant increase in the percent of eligible patients started on buprenorphine maintenance (expected number of patients started postintervention, 27; actual, 64; absolute increase in percent, 14.4%; 95% CI, 3.6%-25.3%; P = .017) (Figure). There was no significant trend during the preintervention period and no significant trend during the postintervention period.

Before the intervention, 13 of the 30 patients (40%) newly started on buprenorphine maintenance during their admission filled a follow-up buprenorphine prescription within 30 days of discharge. After the intervention, 31 of 64 patients (46%) filled a buprenorphine prescription within 30 days (P = .612). Two patients were started on methadone maintenance, one prior to and one after the intervention.

During the 6-month postintervention period, the BBT received 75 requests and wrote 70 prescriptions for buprenorphine. The median time required to complete a BBT request was 15 minutes (minimum, 5 minutes; maximum, 60 minutes).

Of 156 internal medicine and medicine-pediatrics residents, 89 residents (57%) completed the baseline survey and 66 residents (42%) completed the follow-up survey. Forty residents completed both surveys. After the intervention, residents were significantly more likely to feel comfortable dosing buprenorphine (P < .0001) and counseling patients about its use (P = .0237) and were more likely to report ease of establishing follow-up (P < .0001). Self-reported knowledge about preventing precipitated withdrawal increased significantly (P = .0191), as did knowledge about the effectiveness of buprenorphine (P = .0003) independent of formal drug counseling (P = .0066) (Table). Paired survey data also found statistically significant results for all questions except those about preventing precipitated withdrawal and efficacy. For the latter, respondents who completed both surveys were more knowledgeable before the intervention than the overall group that completed the baseline survey (Appendix Table).

This study shows how a resident-led quality improvement project comprising clinician education and implementation of a novel BBT was associated with an increased rate of starting buprenorphine maintenance in hospitalized patients with OUD and improved resident knowledge about and comfort with buprenorphine. To our knowledge, this is the first study demonstrating how education and a team of X-waivered generalists can help primary teams initiate and discharge patients on buprenorphine maintenance in a hospital without an addiction medicine consult service.

Prior to the intervention, resident internal medicine teams at JHH started 10% of hospitalized patients with OUD on buprenorphine maintenance, consistent with prior studies showing rates of 11% to 15% for initiating OAT for hospitalized patients.^11,12 After the intervention, the rate of initiating buprenorphine maintenance more than doubled, rising to 24% of eligible patients. Resident internal medicine teams at JHH started buprenorphine maintenance for 37 more patients over the 24-week postintervention period than would have been predicted prior to the intervention, or an additional three patients every 2 weeks.

Between 40% and 46% of hospitalized patients newly started on buprenorphine maintenance filled an outpatient buprenorphine prescription within 30 days of discharge. We are not aware of comparative data for 30-day follow-up for hospitalized patients newly started on buprenorphine maintenance. Data from other contexts show 5% to 10% of veterans were engaged in addiction treatment 30 days after initiation from inpatient or outpatient encounters. An analysis of an academic medical center in Oregon found engagement with an addiction medicine consult service increased after hospital engagement for patients with any substance use disorder from 23% to 39% using the 34-day HEDIS measure for engagement.^17,24,25

The BBT required approximately 15 minutes per request and wrote an average of three prescriptions per week, demonstrating the feasibility of this approach and the high demand for this service. One strength of our approach is that residents gained experience starting buprenorphine independently using the aforementioned protocol instead of deferring to a full consult service. It is likely that this resident engagement in initiating longitudinal OUD care contributed to the success of this initiative, as did existing resident familiarity with using buprenorphine for opioid withdrawal.

This approach to resident education—promoting direct, first-person experience with medications in a clinical context—aligns with recommendations from a recent review about substance use disorder education for health professionals.²⁶ Our interventions increased resident knowledge and comfort with buprenorphine, consistent with prior studies showing increased resident confidence in management of substance use disorders after curricular innovations.^24,25

A few contextual features were essential for this project’s viability. Maryland allows American medical graduates to obtain a medical license after 1 year of postgraduate training. This allowed three residents to obtain X-waivers. These residents had access to HRSA funding to subsidize the expenses of applying for state licensure and DEA registration. BBT members volunteered their time while working on other services. Last, we were able to take advantage of buprenorphine-providing clinics in Baltimore, including the JHH After Care Clinic, to accept patients for follow-up appointments after discharge.

Limitations

The BBT required motivated clinicians willing to volunteer for additional clinical responsibilities during inpatient rotations and supportive faculty and residency leadership. Attending physicians, nurse practitioners, or physician assistants could staff a similar BBT in hospitals without residents or in hospitals where residents cannot obtain DEA registration. Crucially, other hospitals may not have access to practices with X-waivered physicians for outpatient follow-up. A recent study found X-waivered primary care physicians were less likely to be affiliated with hospital health systems. Other studies have shown limitations in access to buprenorphine at the county level based on geography and racial/ethnic segregation.^27-29

Most patients hospitalized with OUD did not have ICD-10 codes associated with OUD. We addressed this by assuming patients had OUD if buprenorphine or methadone was ordered during their hospitalization, even if the medication was never administered. This may have overcounted patients prescribed these medications for indications other than OUD, and it may have undercounted patients with OUD for whom buprenorphine or methadone were never considered. The opioid withdrawal order set at JHH automatically offers an option to use buprenorphine to treat withdrawal. Patients with OUD for whom buprenorphine or methadone were never ordered likely did not experience withdrawal or were in withdrawal so mild that it escaped the attention of the team, which limits the generalizability of our intervention.

We identified several limitations to the internal validity of our study. First, we used a before-and-after study design without a control group. We could not ethically withhold access to evidence-based, mortality-reducing medications from patients. Without a control group, we cannot rule out the possibility that underlying temporal trends made residents more likely to start buprenorphine maintenance independent of our intervention. We attempted to control for unmeasured confounders by using an interrupted time series analysis to control for preintervention trends, comparing the same group of residents before and after our interventions, and selecting an intervention period during which residents were given only educational sessions and materials provided by our team. Our results may be biased by clustered data because certain residents may have been more likely to initiate buprenorphine, but these effects are likely marginal because resident schedules are balanced between outpatient and inpatient rotations during each 6-month period.

Finally, this project focused on buprenorphine, not on other medications for OUD, including methadone or naltrexone, or nonpharmacologic treatments for OUD.

Since the start of the BBT in January 2019, five additional PGY-2 residents obtained their medical licenses and X-waivers. These residents, with the support of two attending hospitalists, led the BBT and coordinated education sessions that were incorporated into the curriculum during the 2019-2020 academic year. These educational sessions will continue indefinitely. In 2020, JHH started an Addiction Medicine Consult Service staffed by physicians, NPs, and a pharmacist. The BBT continues to operate in conjunction with this service.

We found substantial variability in the rate of buprenorphine maintenance initiation despite our interventions. This is an area for future improvement. In a free-response prompt in our follow-up survey, residents requested additional education sessions and an order set to assist with initiation of buprenorphine. To address these gaps, three educational sessions were added, one of which included education on starting methadone maintenance therapy. We also added a new order set for starting buprenorphine maintenance. We hypothesize that these interventions will improve consistency.

In order for a similar program to be disseminated to other institutions, educational initiatives and a team of dedicated X-waivered prescribers are key. Materials to assist with this process are available in the Appendix.

This study shows how a resident-led intervention comprising clinician education and a team of X-waivered generalists was associated with improved treatment of OUD for hospitalized patients. We encourage residents and all clinicians at other hospitals without addiction medicine consult services to design, implement, and study similar interventions that directly increase the use of buprenorphine or methadone maintenance to treat OUD.

Preliminary results from this project were presented at the AMERSA National Conference on November 7, 2019.

Opioid use disorder (OUD) is a common, underrecognized, undertreated, and deadly medical condition. Although the focus of addressing the opioid epidemic has been centered in the outpatient setting, hospitalists play an important—and often underutilized—role in identifying OUD, initiating treatment, and assisting with linkage to longitudinal care after discharge.

Over the past 20 years, the annual rate of hospital discharges documenting OUD has quadrupled.¹ During 2010-2016, the annual discharge rate for heroin overdoses increased by 23%.¹ Although the total number of hospitalizations in the United States remained stable from 2002 to 2012, the number of admissions for opioid abuse or dependence increased from 301,707 to 520,275. More than 500,000 hospital admissions per year (1% of total nationwide hospitalizations) are now due primarily to OUD.²

Injection opioid use increases the risk of endocarditis, osteomyelitis, septic arthritis, and epidural abscesses, conditions that often prolong hospitalizations and frequently lead to readmissions. Admissions for OUD-related infections are rising at a startling rate. Between 2002 and 2012, the number of admissions for infections associated with OUDs had increased from 3,421 to 6,535.² In addition to providing the opportunity to diagnose OUD, hospitalizations offer an ideal time to engage patients in OUD treatment and linkage to outpatient care.

Although we uniformly offer patients antibiotic treatment for acute infection, hospitalists should consistently incorporate treatment of OUD to address the root cause of these admissions. As infection is but one sequelae of the underlying disease of addiction, treating without medications for OUD (MOUD) would be akin to treating a diabetic foot ulcer with antibiotics and not providing medications to improve glycemic control. Omitting such addiction treatment can contribute to treatment failure and worse health outcomes. Among patients with endocarditis and an associated valve repair, those who continue injection drug use have a 10 times higher risk of death or reoperation between 90 and 180 days after repair than those not engaged in drug use.³

Despite data demonstrating the significant benefit and the minimal harm of MOUD, significant gaps remain in providing MOUD and linking patients from the hospital to community care.^1,4 Hospital encounters are missed opportunities to provide life-saving MOUD treatment; the majority of patients with OUD do not receive evidence-based treatment while inpatient.⁵ Rosenthal et al. found that of 102 patients admitted with injection drug use-associated infective endocarditis from 2004 to 2014, only 8% received MOUD, and approximately half had a documentation of substance use treatment in their discharge worksheet.⁴ In Massachusetts, among individuals who experienced a nonfatal opioid overdose and had interaction with healthcare services, only 26% were on MOUD one year later.⁶ Based on our experience, a substantial proportion of patients with OUD do not seek or have access to medical care, acute care settings offer a critical opportunity to engage them in treatment for their addiction.

First, buprenorphine effectively treats withdrawal symptoms. Buprenorphine and methadone are superior to other medications in treating symptoms of withdrawal.⁷ If withdrawal symptoms are treated, patients are less likely to leave against medical advice⁸ and are more likely to complete treatment.

Second, MOUD is the standard of care for treating OUD.⁹ Medications include the full agonist methadone, the partial agonist buprenorphine, and the long-acting antagonist naltrexone. Although all these drugs are effective and legal to initiate for inpatients,⁶ this perspective focuses on buprenorphine in an effort to draw attention to associated policy barriers. Buprenorphine is the only MOUD that can be offered as office-based therapy by providers in the outpatient setting. Meta-analyses show that MOUD is associated with lower rates of mortality, illicit opioid use, HIV transmission, and violent crime and arrest.⁹

Third, MOUD treatment, rather than just referral, leads to higher long-term treatment success.¹⁰ When initiating buprenorphine in the hospital, treatment retention rates at one month were double that of referral alone. Six months after discharge, patients were five times more likely to remain engaged in treatment compared with those who received a detoxification protocol only.

Fourth, buprenorphine is not only effective, but it is also safe and has low risks of misuse. Because buprenorphine is a partial agonist, it has both a ceiling effect on respiratory depression (decreasing potential lethality) and on euphoria (decreasing the likelihood of misuse). Among individuals who took nonprescribed buprenorphine on the street, less than 7% reported taking it for any attempt at euphoria. Instead, people with OUD most often use nonprescribed or diverted buprenorphine to treat withdrawal symptoms.¹¹

Fifth, buprenorphine treatment is associated with fewer hospital readmissions.¹²

Finally, initiating OUD treatment is feasible in the hospital setting. Any hospitalist can legally prescribe buprenorphine to treat opioid withdrawal for hospitalized patients admitted for medical or surgical reasons. A waiver is necessary only for prescribing at the time of hospital discharge for use in non-inpatient settings of care.

The United States Congress passed the Drug Addiction Treatment Act (DATA) of 2000, which codified the X waiver, in response to the growing opioid crisis. Only those providers with the DATA X waiver can write buprenorphine prescriptions to be filled in an outpatient pharmacy. To obtain an X waiver, physicians must complete an 8-hour course, whereas physician assistants and nurse practitioners must complete a 24-hour course. This training far exceeds any required training to prescribe opioids for pain.

Unfortunately, the X waiver requirement obstructs hospitalists from initiating buprenorphine in the inpatient setting in the following ways: (1) hospitalists often choose not to initiate chronic buprenorphine treatment if they lack the X waiver that would allow them to write the discharge prescription and/or (2) they are unable to identify a waivered provider in the community to continue the prescription. Unfortunately, only 6% of all medical practitioners are waivered to prescribe buprenorphine; greater than 40% of US counties are “buprenorphine deserts,” with no providers waivered to prescribe buprenorphine.¹³

To address the opioid crisis, we must rethink our current policies. The Department of Health and Human Services should eliminate the X waiver and allow any licensed physician, nurse practitioner, or physician assistant to prescribe buprenorphine.¹⁴ Recent American Medical Association Opioid Task Force recommendations have called to “remove… inappropriate administrative burdens or barriers that delay or deny care for FDA-approved medications used as part of medication-assisted treatment for OUD.”¹⁵ Legislation to remove the X wavier has been proposed in the United States.¹⁶

The removal of a buprenorphine waiver requirement has had success in other settings. The French deregulation of buprenorphine was associated with a reduction in opioid overdose deaths by 79%. Similar success in the United States would save an estimated 30,000 lives yearly.¹⁴ Removing the X waiver is an important step in empowering hospitalists to initiate MOUD for individuals in the hospital setting. Moreover, it opens the door to more outpatient primary care providers serving as community linkages for long-term addiction care.

Without the X waiver, the associated OUD training will no longer be required. This could have unintended consequences. For example, if hospitalists order buprenorphine while opioids remain active, precipitated withdrawal may ensue. Crucially, the current literature does not indicate that the required X waiver training improves knowledge, patient care, or outcomes.¹⁷ Nevertheless, MOUD and addiction training may help reduce knowledge gaps and empower providers to engage in productive conversations surrounding addiction. This highlights the crucial role of physician organizations, such as the Society of Hospital Medicine, in educating hospitalists about MOUD. (This organization, among others, has developed robust MOUD training.¹⁸)

It is also important to acknowledge that the waiver is only one obstacle. Other barriers have been identified in initiating buprenorphine, including access to treatment after discharge, access to social work support, and lack of EMR order sets, among others.¹⁹ Professional societies, hospitals, and hospitalists need to help address these barriers through ancillary support staff, quality improvement initiatives, and improved inpatient treatment of withdrawal with MOUD. This can be done successfully; one study found that 82% of hospitalized patients who engaged in a new transitional opioid program subsequently presented to outpatient opioid treatment.²⁰ Novel interventions must be part of a hospital-wide approach to optimizing improved longitudinal treatment for patients suffering from addiction.

Hospitalization is an ideal opportunity for clinicians to diagnose and treat OUD in a population that often has not sought, or has fallen out of, addiction treatment. Hospitalists can and should initiate buprenorphine in appropriate inpatients and plan for their transition to chronic care. Eliminating the waiver in combination with designing innovative educational opportunities and systems approaches to provide better linkages to outpatient OUD treatment is needed to combat the opioid crisis. To enable more hospitalists to successfully initiate long-term buprenorphine therapy—and to enable more outpatient providers to continue prescriptions—we must eliminate the X waiver.

Disclosures

Dr. Wilson received honorarium from the American Society of Addiction Medicine for teaching and creating CME outside the submitted work. All other authors have no conflicts of interest and have received no related funding to this topic.

Opioid use disorder (OUD) is a common, underrecognized, undertreated, and deadly medical condition. Although the focus of addressing the opioid epidemic has been centered in the outpatient setting, hospitalists play an important—and often underutilized—role in identifying OUD, initiating treatment, and assisting with linkage to longitudinal care after discharge.

Over the past 20 years, the annual rate of hospital discharges documenting OUD has quadrupled.¹ During 2010-2016, the annual discharge rate for heroin overdoses increased by 23%.¹ Although the total number of hospitalizations in the United States remained stable from 2002 to 2012, the number of admissions for opioid abuse or dependence increased from 301,707 to 520,275. More than 500,000 hospital admissions per year (1% of total nationwide hospitalizations) are now due primarily to OUD.²

Injection opioid use increases the risk of endocarditis, osteomyelitis, septic arthritis, and epidural abscesses, conditions that often prolong hospitalizations and frequently lead to readmissions. Admissions for OUD-related infections are rising at a startling rate. Between 2002 and 2012, the number of admissions for infections associated with OUDs had increased from 3,421 to 6,535.² In addition to providing the opportunity to diagnose OUD, hospitalizations offer an ideal time to engage patients in OUD treatment and linkage to outpatient care.

Although we uniformly offer patients antibiotic treatment for acute infection, hospitalists should consistently incorporate treatment of OUD to address the root cause of these admissions. As infection is but one sequelae of the underlying disease of addiction, treating without medications for OUD (MOUD) would be akin to treating a diabetic foot ulcer with antibiotics and not providing medications to improve glycemic control. Omitting such addiction treatment can contribute to treatment failure and worse health outcomes. Among patients with endocarditis and an associated valve repair, those who continue injection drug use have a 10 times higher risk of death or reoperation between 90 and 180 days after repair than those not engaged in drug use.³

Despite data demonstrating the significant benefit and the minimal harm of MOUD, significant gaps remain in providing MOUD and linking patients from the hospital to community care.^1,4 Hospital encounters are missed opportunities to provide life-saving MOUD treatment; the majority of patients with OUD do not receive evidence-based treatment while inpatient.⁵ Rosenthal et al. found that of 102 patients admitted with injection drug use-associated infective endocarditis from 2004 to 2014, only 8% received MOUD, and approximately half had a documentation of substance use treatment in their discharge worksheet.⁴ In Massachusetts, among individuals who experienced a nonfatal opioid overdose and had interaction with healthcare services, only 26% were on MOUD one year later.⁶ Based on our experience, a substantial proportion of patients with OUD do not seek or have access to medical care, acute care settings offer a critical opportunity to engage them in treatment for their addiction.

First, buprenorphine effectively treats withdrawal symptoms. Buprenorphine and methadone are superior to other medications in treating symptoms of withdrawal.⁷ If withdrawal symptoms are treated, patients are less likely to leave against medical advice⁸ and are more likely to complete treatment.

Second, MOUD is the standard of care for treating OUD.⁹ Medications include the full agonist methadone, the partial agonist buprenorphine, and the long-acting antagonist naltrexone. Although all these drugs are effective and legal to initiate for inpatients,⁶ this perspective focuses on buprenorphine in an effort to draw attention to associated policy barriers. Buprenorphine is the only MOUD that can be offered as office-based therapy by providers in the outpatient setting. Meta-analyses show that MOUD is associated with lower rates of mortality, illicit opioid use, HIV transmission, and violent crime and arrest.⁹

Third, MOUD treatment, rather than just referral, leads to higher long-term treatment success.¹⁰ When initiating buprenorphine in the hospital, treatment retention rates at one month were double that of referral alone. Six months after discharge, patients were five times more likely to remain engaged in treatment compared with those who received a detoxification protocol only.

Fourth, buprenorphine is not only effective, but it is also safe and has low risks of misuse. Because buprenorphine is a partial agonist, it has both a ceiling effect on respiratory depression (decreasing potential lethality) and on euphoria (decreasing the likelihood of misuse). Among individuals who took nonprescribed buprenorphine on the street, less than 7% reported taking it for any attempt at euphoria. Instead, people with OUD most often use nonprescribed or diverted buprenorphine to treat withdrawal symptoms.¹¹

Fifth, buprenorphine treatment is associated with fewer hospital readmissions.¹²

Finally, initiating OUD treatment is feasible in the hospital setting. Any hospitalist can legally prescribe buprenorphine to treat opioid withdrawal for hospitalized patients admitted for medical or surgical reasons. A waiver is necessary only for prescribing at the time of hospital discharge for use in non-inpatient settings of care.

The United States Congress passed the Drug Addiction Treatment Act (DATA) of 2000, which codified the X waiver, in response to the growing opioid crisis. Only those providers with the DATA X waiver can write buprenorphine prescriptions to be filled in an outpatient pharmacy. To obtain an X waiver, physicians must complete an 8-hour course, whereas physician assistants and nurse practitioners must complete a 24-hour course. This training far exceeds any required training to prescribe opioids for pain.

Unfortunately, the X waiver requirement obstructs hospitalists from initiating buprenorphine in the inpatient setting in the following ways: (1) hospitalists often choose not to initiate chronic buprenorphine treatment if they lack the X waiver that would allow them to write the discharge prescription and/or (2) they are unable to identify a waivered provider in the community to continue the prescription. Unfortunately, only 6% of all medical practitioners are waivered to prescribe buprenorphine; greater than 40% of US counties are “buprenorphine deserts,” with no providers waivered to prescribe buprenorphine.¹³

To address the opioid crisis, we must rethink our current policies. The Department of Health and Human Services should eliminate the X waiver and allow any licensed physician, nurse practitioner, or physician assistant to prescribe buprenorphine.¹⁴ Recent American Medical Association Opioid Task Force recommendations have called to “remove… inappropriate administrative burdens or barriers that delay or deny care for FDA-approved medications used as part of medication-assisted treatment for OUD.”¹⁵ Legislation to remove the X wavier has been proposed in the United States.¹⁶

The removal of a buprenorphine waiver requirement has had success in other settings. The French deregulation of buprenorphine was associated with a reduction in opioid overdose deaths by 79%. Similar success in the United States would save an estimated 30,000 lives yearly.¹⁴ Removing the X waiver is an important step in empowering hospitalists to initiate MOUD for individuals in the hospital setting. Moreover, it opens the door to more outpatient primary care providers serving as community linkages for long-term addiction care.

Without the X waiver, the associated OUD training will no longer be required. This could have unintended consequences. For example, if hospitalists order buprenorphine while opioids remain active, precipitated withdrawal may ensue. Crucially, the current literature does not indicate that the required X waiver training improves knowledge, patient care, or outcomes.¹⁷ Nevertheless, MOUD and addiction training may help reduce knowledge gaps and empower providers to engage in productive conversations surrounding addiction. This highlights the crucial role of physician organizations, such as the Society of Hospital Medicine, in educating hospitalists about MOUD. (This organization, among others, has developed robust MOUD training.¹⁸)

It is also important to acknowledge that the waiver is only one obstacle. Other barriers have been identified in initiating buprenorphine, including access to treatment after discharge, access to social work support, and lack of EMR order sets, among others.¹⁹ Professional societies, hospitals, and hospitalists need to help address these barriers through ancillary support staff, quality improvement initiatives, and improved inpatient treatment of withdrawal with MOUD. This can be done successfully; one study found that 82% of hospitalized patients who engaged in a new transitional opioid program subsequently presented to outpatient opioid treatment.²⁰ Novel interventions must be part of a hospital-wide approach to optimizing improved longitudinal treatment for patients suffering from addiction.

Hospitalization is an ideal opportunity for clinicians to diagnose and treat OUD in a population that often has not sought, or has fallen out of, addiction treatment. Hospitalists can and should initiate buprenorphine in appropriate inpatients and plan for their transition to chronic care. Eliminating the waiver in combination with designing innovative educational opportunities and systems approaches to provide better linkages to outpatient OUD treatment is needed to combat the opioid crisis. To enable more hospitalists to successfully initiate long-term buprenorphine therapy—and to enable more outpatient providers to continue prescriptions—we must eliminate the X waiver.

Disclosures

Dr. Wilson received honorarium from the American Society of Addiction Medicine for teaching and creating CME outside the submitted work. All other authors have no conflicts of interest and have received no related funding to this topic.

Opioid use disorder (OUD) is a common, underrecognized, undertreated, and deadly medical condition. Although the focus of addressing the opioid epidemic has been centered in the outpatient setting, hospitalists play an important—and often underutilized—role in identifying OUD, initiating treatment, and assisting with linkage to longitudinal care after discharge.

Over the past 20 years, the annual rate of hospital discharges documenting OUD has quadrupled.¹ During 2010-2016, the annual discharge rate for heroin overdoses increased by 23%.¹ Although the total number of hospitalizations in the United States remained stable from 2002 to 2012, the number of admissions for opioid abuse or dependence increased from 301,707 to 520,275. More than 500,000 hospital admissions per year (1% of total nationwide hospitalizations) are now due primarily to OUD.²

Injection opioid use increases the risk of endocarditis, osteomyelitis, septic arthritis, and epidural abscesses, conditions that often prolong hospitalizations and frequently lead to readmissions. Admissions for OUD-related infections are rising at a startling rate. Between 2002 and 2012, the number of admissions for infections associated with OUDs had increased from 3,421 to 6,535.² In addition to providing the opportunity to diagnose OUD, hospitalizations offer an ideal time to engage patients in OUD treatment and linkage to outpatient care.

Although we uniformly offer patients antibiotic treatment for acute infection, hospitalists should consistently incorporate treatment of OUD to address the root cause of these admissions. As infection is but one sequelae of the underlying disease of addiction, treating without medications for OUD (MOUD) would be akin to treating a diabetic foot ulcer with antibiotics and not providing medications to improve glycemic control. Omitting such addiction treatment can contribute to treatment failure and worse health outcomes. Among patients with endocarditis and an associated valve repair, those who continue injection drug use have a 10 times higher risk of death or reoperation between 90 and 180 days after repair than those not engaged in drug use.³

Despite data demonstrating the significant benefit and the minimal harm of MOUD, significant gaps remain in providing MOUD and linking patients from the hospital to community care.^1,4 Hospital encounters are missed opportunities to provide life-saving MOUD treatment; the majority of patients with OUD do not receive evidence-based treatment while inpatient.⁵ Rosenthal et al. found that of 102 patients admitted with injection drug use-associated infective endocarditis from 2004 to 2014, only 8% received MOUD, and approximately half had a documentation of substance use treatment in their discharge worksheet.⁴ In Massachusetts, among individuals who experienced a nonfatal opioid overdose and had interaction with healthcare services, only 26% were on MOUD one year later.⁶ Based on our experience, a substantial proportion of patients with OUD do not seek or have access to medical care, acute care settings offer a critical opportunity to engage them in treatment for their addiction.

First, buprenorphine effectively treats withdrawal symptoms. Buprenorphine and methadone are superior to other medications in treating symptoms of withdrawal.⁷ If withdrawal symptoms are treated, patients are less likely to leave against medical advice⁸ and are more likely to complete treatment.

Second, MOUD is the standard of care for treating OUD.⁹ Medications include the full agonist methadone, the partial agonist buprenorphine, and the long-acting antagonist naltrexone. Although all these drugs are effective and legal to initiate for inpatients,⁶ this perspective focuses on buprenorphine in an effort to draw attention to associated policy barriers. Buprenorphine is the only MOUD that can be offered as office-based therapy by providers in the outpatient setting. Meta-analyses show that MOUD is associated with lower rates of mortality, illicit opioid use, HIV transmission, and violent crime and arrest.⁹

Third, MOUD treatment, rather than just referral, leads to higher long-term treatment success.¹⁰ When initiating buprenorphine in the hospital, treatment retention rates at one month were double that of referral alone. Six months after discharge, patients were five times more likely to remain engaged in treatment compared with those who received a detoxification protocol only.

Fourth, buprenorphine is not only effective, but it is also safe and has low risks of misuse. Because buprenorphine is a partial agonist, it has both a ceiling effect on respiratory depression (decreasing potential lethality) and on euphoria (decreasing the likelihood of misuse). Among individuals who took nonprescribed buprenorphine on the street, less than 7% reported taking it for any attempt at euphoria. Instead, people with OUD most often use nonprescribed or diverted buprenorphine to treat withdrawal symptoms.¹¹

Fifth, buprenorphine treatment is associated with fewer hospital readmissions.¹²

Finally, initiating OUD treatment is feasible in the hospital setting. Any hospitalist can legally prescribe buprenorphine to treat opioid withdrawal for hospitalized patients admitted for medical or surgical reasons. A waiver is necessary only for prescribing at the time of hospital discharge for use in non-inpatient settings of care.

The United States Congress passed the Drug Addiction Treatment Act (DATA) of 2000, which codified the X waiver, in response to the growing opioid crisis. Only those providers with the DATA X waiver can write buprenorphine prescriptions to be filled in an outpatient pharmacy. To obtain an X waiver, physicians must complete an 8-hour course, whereas physician assistants and nurse practitioners must complete a 24-hour course. This training far exceeds any required training to prescribe opioids for pain.

Unfortunately, the X waiver requirement obstructs hospitalists from initiating buprenorphine in the inpatient setting in the following ways: (1) hospitalists often choose not to initiate chronic buprenorphine treatment if they lack the X waiver that would allow them to write the discharge prescription and/or (2) they are unable to identify a waivered provider in the community to continue the prescription. Unfortunately, only 6% of all medical practitioners are waivered to prescribe buprenorphine; greater than 40% of US counties are “buprenorphine deserts,” with no providers waivered to prescribe buprenorphine.¹³

To address the opioid crisis, we must rethink our current policies. The Department of Health and Human Services should eliminate the X waiver and allow any licensed physician, nurse practitioner, or physician assistant to prescribe buprenorphine.¹⁴ Recent American Medical Association Opioid Task Force recommendations have called to “remove… inappropriate administrative burdens or barriers that delay or deny care for FDA-approved medications used as part of medication-assisted treatment for OUD.”¹⁵ Legislation to remove the X wavier has been proposed in the United States.¹⁶

The removal of a buprenorphine waiver requirement has had success in other settings. The French deregulation of buprenorphine was associated with a reduction in opioid overdose deaths by 79%. Similar success in the United States would save an estimated 30,000 lives yearly.¹⁴ Removing the X waiver is an important step in empowering hospitalists to initiate MOUD for individuals in the hospital setting. Moreover, it opens the door to more outpatient primary care providers serving as community linkages for long-term addiction care.

Without the X waiver, the associated OUD training will no longer be required. This could have unintended consequences. For example, if hospitalists order buprenorphine while opioids remain active, precipitated withdrawal may ensue. Crucially, the current literature does not indicate that the required X waiver training improves knowledge, patient care, or outcomes.¹⁷ Nevertheless, MOUD and addiction training may help reduce knowledge gaps and empower providers to engage in productive conversations surrounding addiction. This highlights the crucial role of physician organizations, such as the Society of Hospital Medicine, in educating hospitalists about MOUD. (This organization, among others, has developed robust MOUD training.¹⁸)

It is also important to acknowledge that the waiver is only one obstacle. Other barriers have been identified in initiating buprenorphine, including access to treatment after discharge, access to social work support, and lack of EMR order sets, among others.¹⁹ Professional societies, hospitals, and hospitalists need to help address these barriers through ancillary support staff, quality improvement initiatives, and improved inpatient treatment of withdrawal with MOUD. This can be done successfully; one study found that 82% of hospitalized patients who engaged in a new transitional opioid program subsequently presented to outpatient opioid treatment.²⁰ Novel interventions must be part of a hospital-wide approach to optimizing improved longitudinal treatment for patients suffering from addiction.

Hospitalization is an ideal opportunity for clinicians to diagnose and treat OUD in a population that often has not sought, or has fallen out of, addiction treatment. Hospitalists can and should initiate buprenorphine in appropriate inpatients and plan for their transition to chronic care. Eliminating the waiver in combination with designing innovative educational opportunities and systems approaches to provide better linkages to outpatient OUD treatment is needed to combat the opioid crisis. To enable more hospitalists to successfully initiate long-term buprenorphine therapy—and to enable more outpatient providers to continue prescriptions—we must eliminate the X waiver.

Disclosures

Dr. Wilson received honorarium from the American Society of Addiction Medicine for teaching and creating CME outside the submitted work. All other authors have no conflicts of interest and have received no related funding to this topic.

Reducing the treatment of asymptomatic bacteriuria (ASB), or isolation of bacteria from a urine specimen in a patient without urinary tract infection (UTI) symptoms, is a key goal of antibiotic stewardship programs.¹ Treatment of ASB has been associated with the emergence of resistant organisms and subsequent UTI risk among women with recurrent UTI.^2,3 The Infectious Diseases Society of America and the American Board of Internal Medicine Foundation’s Choosing Wisely campaign recommend against treating ASB, with the exception of pregnant patients and urogenital surgical patients.^1,4

Obtaining urinalyses and urine cultures (UC) in asymptomatic patients may contribute to the unnecessary treatment of ASB. In a study of hospitalized patients, 62% received urinalysis testing, even though 82% of these patients did not have UTI symptoms.⁵ Of the patients found to have ASB, 30% were given antibiotics.⁵ Therefore, interventions aimed at reducing urine testing may reduce ASB treatment.

Electronic passive clinical decision support (CDS) alerts and electronic education may be effective interventions to reduce urine testing.⁶ While CDS tools are recommended in antibiotic stewardship guidelines,⁷ they have led to only modest improvements in appropriate antibiotic prescribing and are typically bundled with time-intensive educational interventions.⁸ Furthermore, most in-hospital interventions to decrease ASB treatment have focused on intensive care units (ICUs).⁹ We hypothesized that CDS and electronic education would decrease (1) urinalysis and UC ordering and (2) antibiotic orders for urinalyses and UCs in hospitalized adult patients.

Population

We conducted a prospective time series analysis (preintervention: September 2014 to June 2015; postintervention: September 2015 to June 2016) at a large tertiary medical center. All hospitalized patients ≥18 years old were eligible except those admitted to services requiring specialized ASB management (eg, leukemia and lymphoma, solid organ transplant, and obstetrics).¹ The study was declared quality improvement by the Johns Hopkins Institutional Review Board.

Intervention

In August 2015, we implemented a multifaceted intervention that included provider education and passive electronic CDS (supplementary Appendix 1 and supplementary Appendix 2). Materials were disseminated through hospital-wide computer workstation screensavers and a 1-page e-mailed newsletter to department of medicine clinicians. The CDS tool included simple informational messages recommending against urine testing without symptoms and against treating ASB; these messages accompanied electronic health record (EHR; Allscripts Sunrise Clinical Manager, Chicago, IL) orders for urinalysis, UC, and antibiotics commonly used within our institution to treat UTI (cefazolin, cephalexin, ceftriaxone, trimethoprim-sulfamethoxazole, nitrofurantoin, and ciprofloxacin). The information was displayed automatically when orders for these tests and antibiotics were selected; provider acknowledgment was not required to proceed.

Data Collection

The services within our hospital are geographically located. We collected orders for urinalysis, UC, and the associated antibiotics for all units except those housing patients excluded from our study. As the CDS tool appeared only in the inpatient EHR, only postadmission orders were included, excluding emergency department orders. For admissions with multiple urinalyses, urinalysis orders placed ≥72 hours apart were eligible. Only antibiotics ordered for ≥24 hours were included, excluding on-call and 1-time antibiotic orders.

Our approach to data collection attempted to model a clinician’s decision-making pathway from (1) ordering a urinalysis, to (2) ordering a UC in response to a urinalysis result, to (3) ordering antibiotics in response to a urinalysis or UC result. We focused on order placement rather than results to prioritize avoiding testing in asymptomatic patients, as our institution does not require positive urinalyses for UC testing (reflex testing). Urinalyses resulted within 1 to 2 hours, allowing for clinicians to quickly order UCs after urinalysis result review. Urinalysis and UC orders per monthly admissions were defined as (1) urinalyses, (2) UCs, (3) simultaneous urinalysis and UC (within 1 hour of each other), and (4) UCs ordered 1 to 24 hours after urinalysis. We also analyzed the following antibiotic orders per monthly admissions: (1) simultaneous urinalysis and antibiotic orders, (2) antibiotics ordered 1 to 24 hours after urinalysis order, and (3) antibiotics ordered within 24 hours of the UC result.

Outcome Measures

All outcome measures were calculated as the change over time per total monthly admissions in the preintervention and postintervention periods. In addition to symptoms, urinalysis is a critical, measurable early step in determining the presence of ASB. Therefore, the primary outcome measure was the postintervention change in monthly urinalysis orders, and the secondary outcome measure was the postintervention change in monthly UC orders. Additional outcome measures included monthly postintervention changes in (1) UC ordered 1 to 24 hours after urinalyses, (2) urinalyses and antibiotics ordered simultaneously, (3) antibiotic orders within 1 to 24 hours of urinalyses, and (4) antibiotics ordered within 24 hours of UC result.

Statistical Analysis

Statistical analyses were performed by using Stata (version 14.2; StataCorp LLC, College Station, TX). An interrupted time series analysis was performed to compare the change in orders per 100 monthly admissions in preintervention and postintervention periods. To do this, we created 2 separate segmented linear regression models for each dependent variable, pre- and postintervention. Normality was assumed because of large numbers. Rate differences per 100 monthly admissions are also calculated as the total number of orders divided by the total number of admissions in postintervention and preintervention periods with Mantel-Haenszel estimators. Differences were considered statistically significant at P ≤ .05.

A multifaceted but simple bundle of CDS and provider education reduced UC testing but not urinalyses in a large tertiary care hospital. The bundle also reduced antibiotic ordering in response to urinalyses as well as antibiotic ordering in response to UC results.

Other in-hospital CDS tools to decrease ASB treatment have focused only on ICUs.^9,10 Our intervention was evaluated hospital-wide and included urinalyses and UCs. Our intervention was clinician directed and not laboratory directed, such as a positive urinalysis reflexing to a UC. Simultaneous urinalysis and UC testing may lead to ASB treatment, as clinicians treat the positive UC and ignore the negative urinalysis.^11,12 Therefore, we focused on UCs being sent in response to urinalyses.

We chose to focus on laboratory testing data instead of administrative diagnoses for UTI. The sensitivity of administrative data to determine similar conditions such as catheter-associated UTIs is low (0%).¹³

Our single-center study may not be generalizable to other settings. We did not include emergency department patients, as this location used a different EHR. In addition, given the 600,000 yearly hospital admissions, it was impractical to assess the appropriateness of each antibiotic-based documentation of symptoms. Instead of focusing on symptoms of ASB or UTI diagnoses, we focused on ordering urinalysis, UC, and antibiotics. In investigating the antibiotics most frequently used to treat UTI in our hospital, we may have both missed some patients who were treated with other antibiotics for ASB (eg, 4th generation cephalosporins, penicillins, carbapenems, etc) and captured patients receiving antibiotics for indications other than UTI (eg, pneumonia). In our focus on overall ordering practices across a hospital, we did not capture data on bladder catheterization status or the predominant organism seen in UC. At the time of the intervention, the laboratory did not have the resources for urinalysis testing reflexing to UC. However, our intervention did not prevent ordering simultaneous urinalysis and UC in symptomatic patients in general or urosepsis in particular. With only 12 total time points, the interrupted time series analysis may have been underpowered.¹⁴ We also do not know if the intervention’s effect would decay over time.

Although the intervention took very little staff time and resources, alert fatigue was a risk.¹⁵ We attempted to mitigate this alert fatigue by making the CDS passive (in the form of a brief informational message) with no provider action required. In conversations with providers in our institution, there has been dissatisfaction with alerts requiring action, as these are thought to be overly intrusive. We are also not clear on which element of the intervention bundle (ie, the CDS or the educational intervention) may have had more of an impact, as the elements of the intervention bundle were rolled out simultaneously. It is possible and even probable that both elements are needed to raise awareness of the problem. Also, as our EHR required all interventions to be rolled out hospital-wide simultaneously, we were unable to randomize certain floors or providers to the CDS portion of the intervention bundle. Other analyses including the type of hospital unit were beyond the scope of this brief report.

Our intervention bundle was associated with reduced UC orders and reduced antibiotics ordered after urinalyses. If a provider does not know there is bacteriuria, then the provider will not be tempted to order antibiotics. This easily implementable bundle may play an important role as an antimicrobial stewardship strategy for ASB.

Acknowledgments

The authors acknowledge the support of Erin Fanning, BS, and Angel Florentin, BS, in providing data for analysis. SCK received funding from the Johns Hopkins Institute for Clinical and Translational Research (ICTR), which is funded in part by grant number KL2TR001077 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research. These contents are solely the responsibility of the authors and do not necessarily represent the official view of the Johns Hopkins ICTR, NCATS, or NIH. We also acknowledge support from the Centers for Disease Control and Prevention’s Prevention Epicenter Program Q8377 (collaborative agreement U54 CK000447 to SEC). SEC has received support for consulting from Novartis and Theravance, and her institution has received a grant from Pfizer Grants for Learning and Change/The Joint Commission. This work was supported by the NIH T32 HL116275 to NC. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Disclosure

No conflicts of interest have been reported by any author.

Reducing the treatment of asymptomatic bacteriuria (ASB), or isolation of bacteria from a urine specimen in a patient without urinary tract infection (UTI) symptoms, is a key goal of antibiotic stewardship programs.¹ Treatment of ASB has been associated with the emergence of resistant organisms and subsequent UTI risk among women with recurrent UTI.^2,3 The Infectious Diseases Society of America and the American Board of Internal Medicine Foundation’s Choosing Wisely campaign recommend against treating ASB, with the exception of pregnant patients and urogenital surgical patients.^1,4

Obtaining urinalyses and urine cultures (UC) in asymptomatic patients may contribute to the unnecessary treatment of ASB. In a study of hospitalized patients, 62% received urinalysis testing, even though 82% of these patients did not have UTI symptoms.⁵ Of the patients found to have ASB, 30% were given antibiotics.⁵ Therefore, interventions aimed at reducing urine testing may reduce ASB treatment.

Electronic passive clinical decision support (CDS) alerts and electronic education may be effective interventions to reduce urine testing.⁶ While CDS tools are recommended in antibiotic stewardship guidelines,⁷ they have led to only modest improvements in appropriate antibiotic prescribing and are typically bundled with time-intensive educational interventions.⁸ Furthermore, most in-hospital interventions to decrease ASB treatment have focused on intensive care units (ICUs).⁹ We hypothesized that CDS and electronic education would decrease (1) urinalysis and UC ordering and (2) antibiotic orders for urinalyses and UCs in hospitalized adult patients.

Population

We conducted a prospective time series analysis (preintervention: September 2014 to June 2015; postintervention: September 2015 to June 2016) at a large tertiary medical center. All hospitalized patients ≥18 years old were eligible except those admitted to services requiring specialized ASB management (eg, leukemia and lymphoma, solid organ transplant, and obstetrics).¹ The study was declared quality improvement by the Johns Hopkins Institutional Review Board.

Intervention

In August 2015, we implemented a multifaceted intervention that included provider education and passive electronic CDS (supplementary Appendix 1 and supplementary Appendix 2). Materials were disseminated through hospital-wide computer workstation screensavers and a 1-page e-mailed newsletter to department of medicine clinicians. The CDS tool included simple informational messages recommending against urine testing without symptoms and against treating ASB; these messages accompanied electronic health record (EHR; Allscripts Sunrise Clinical Manager, Chicago, IL) orders for urinalysis, UC, and antibiotics commonly used within our institution to treat UTI (cefazolin, cephalexin, ceftriaxone, trimethoprim-sulfamethoxazole, nitrofurantoin, and ciprofloxacin). The information was displayed automatically when orders for these tests and antibiotics were selected; provider acknowledgment was not required to proceed.

Data Collection

The services within our hospital are geographically located. We collected orders for urinalysis, UC, and the associated antibiotics for all units except those housing patients excluded from our study. As the CDS tool appeared only in the inpatient EHR, only postadmission orders were included, excluding emergency department orders. For admissions with multiple urinalyses, urinalysis orders placed ≥72 hours apart were eligible. Only antibiotics ordered for ≥24 hours were included, excluding on-call and 1-time antibiotic orders.

Our approach to data collection attempted to model a clinician’s decision-making pathway from (1) ordering a urinalysis, to (2) ordering a UC in response to a urinalysis result, to (3) ordering antibiotics in response to a urinalysis or UC result. We focused on order placement rather than results to prioritize avoiding testing in asymptomatic patients, as our institution does not require positive urinalyses for UC testing (reflex testing). Urinalyses resulted within 1 to 2 hours, allowing for clinicians to quickly order UCs after urinalysis result review. Urinalysis and UC orders per monthly admissions were defined as (1) urinalyses, (2) UCs, (3) simultaneous urinalysis and UC (within 1 hour of each other), and (4) UCs ordered 1 to 24 hours after urinalysis. We also analyzed the following antibiotic orders per monthly admissions: (1) simultaneous urinalysis and antibiotic orders, (2) antibiotics ordered 1 to 24 hours after urinalysis order, and (3) antibiotics ordered within 24 hours of the UC result.

Outcome Measures

All outcome measures were calculated as the change over time per total monthly admissions in the preintervention and postintervention periods. In addition to symptoms, urinalysis is a critical, measurable early step in determining the presence of ASB. Therefore, the primary outcome measure was the postintervention change in monthly urinalysis orders, and the secondary outcome measure was the postintervention change in monthly UC orders. Additional outcome measures included monthly postintervention changes in (1) UC ordered 1 to 24 hours after urinalyses, (2) urinalyses and antibiotics ordered simultaneously, (3) antibiotic orders within 1 to 24 hours of urinalyses, and (4) antibiotics ordered within 24 hours of UC result.

Statistical Analysis

Statistical analyses were performed by using Stata (version 14.2; StataCorp LLC, College Station, TX). An interrupted time series analysis was performed to compare the change in orders per 100 monthly admissions in preintervention and postintervention periods. To do this, we created 2 separate segmented linear regression models for each dependent variable, pre- and postintervention. Normality was assumed because of large numbers. Rate differences per 100 monthly admissions are also calculated as the total number of orders divided by the total number of admissions in postintervention and preintervention periods with Mantel-Haenszel estimators. Differences were considered statistically significant at P ≤ .05.

A multifaceted but simple bundle of CDS and provider education reduced UC testing but not urinalyses in a large tertiary care hospital. The bundle also reduced antibiotic ordering in response to urinalyses as well as antibiotic ordering in response to UC results.

Other in-hospital CDS tools to decrease ASB treatment have focused only on ICUs.^9,10 Our intervention was evaluated hospital-wide and included urinalyses and UCs. Our intervention was clinician directed and not laboratory directed, such as a positive urinalysis reflexing to a UC. Simultaneous urinalysis and UC testing may lead to ASB treatment, as clinicians treat the positive UC and ignore the negative urinalysis.^11,12 Therefore, we focused on UCs being sent in response to urinalyses.

We chose to focus on laboratory testing data instead of administrative diagnoses for UTI. The sensitivity of administrative data to determine similar conditions such as catheter-associated UTIs is low (0%).¹³

Our single-center study may not be generalizable to other settings. We did not include emergency department patients, as this location used a different EHR. In addition, given the 600,000 yearly hospital admissions, it was impractical to assess the appropriateness of each antibiotic-based documentation of symptoms. Instead of focusing on symptoms of ASB or UTI diagnoses, we focused on ordering urinalysis, UC, and antibiotics. In investigating the antibiotics most frequently used to treat UTI in our hospital, we may have both missed some patients who were treated with other antibiotics for ASB (eg, 4th generation cephalosporins, penicillins, carbapenems, etc) and captured patients receiving antibiotics for indications other than UTI (eg, pneumonia). In our focus on overall ordering practices across a hospital, we did not capture data on bladder catheterization status or the predominant organism seen in UC. At the time of the intervention, the laboratory did not have the resources for urinalysis testing reflexing to UC. However, our intervention did not prevent ordering simultaneous urinalysis and UC in symptomatic patients in general or urosepsis in particular. With only 12 total time points, the interrupted time series analysis may have been underpowered.¹⁴ We also do not know if the intervention’s effect would decay over time.

Although the intervention took very little staff time and resources, alert fatigue was a risk.¹⁵ We attempted to mitigate this alert fatigue by making the CDS passive (in the form of a brief informational message) with no provider action required. In conversations with providers in our institution, there has been dissatisfaction with alerts requiring action, as these are thought to be overly intrusive. We are also not clear on which element of the intervention bundle (ie, the CDS or the educational intervention) may have had more of an impact, as the elements of the intervention bundle were rolled out simultaneously. It is possible and even probable that both elements are needed to raise awareness of the problem. Also, as our EHR required all interventions to be rolled out hospital-wide simultaneously, we were unable to randomize certain floors or providers to the CDS portion of the intervention bundle. Other analyses including the type of hospital unit were beyond the scope of this brief report.

Our intervention bundle was associated with reduced UC orders and reduced antibiotics ordered after urinalyses. If a provider does not know there is bacteriuria, then the provider will not be tempted to order antibiotics. This easily implementable bundle may play an important role as an antimicrobial stewardship strategy for ASB.

Acknowledgments

The authors acknowledge the support of Erin Fanning, BS, and Angel Florentin, BS, in providing data for analysis. SCK received funding from the Johns Hopkins Institute for Clinical and Translational Research (ICTR), which is funded in part by grant number KL2TR001077 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research. These contents are solely the responsibility of the authors and do not necessarily represent the official view of the Johns Hopkins ICTR, NCATS, or NIH. We also acknowledge support from the Centers for Disease Control and Prevention’s Prevention Epicenter Program Q8377 (collaborative agreement U54 CK000447 to SEC). SEC has received support for consulting from Novartis and Theravance, and her institution has received a grant from Pfizer Grants for Learning and Change/The Joint Commission. This work was supported by the NIH T32 HL116275 to NC. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Disclosure

No conflicts of interest have been reported by any author.

Reducing the treatment of asymptomatic bacteriuria (ASB), or isolation of bacteria from a urine specimen in a patient without urinary tract infection (UTI) symptoms, is a key goal of antibiotic stewardship programs.¹ Treatment of ASB has been associated with the emergence of resistant organisms and subsequent UTI risk among women with recurrent UTI.^2,3 The Infectious Diseases Society of America and the American Board of Internal Medicine Foundation’s Choosing Wisely campaign recommend against treating ASB, with the exception of pregnant patients and urogenital surgical patients.^1,4

Obtaining urinalyses and urine cultures (UC) in asymptomatic patients may contribute to the unnecessary treatment of ASB. In a study of hospitalized patients, 62% received urinalysis testing, even though 82% of these patients did not have UTI symptoms.⁵ Of the patients found to have ASB, 30% were given antibiotics.⁵ Therefore, interventions aimed at reducing urine testing may reduce ASB treatment.

Electronic passive clinical decision support (CDS) alerts and electronic education may be effective interventions to reduce urine testing.⁶ While CDS tools are recommended in antibiotic stewardship guidelines,⁷ they have led to only modest improvements in appropriate antibiotic prescribing and are typically bundled with time-intensive educational interventions.⁸ Furthermore, most in-hospital interventions to decrease ASB treatment have focused on intensive care units (ICUs).⁹ We hypothesized that CDS and electronic education would decrease (1) urinalysis and UC ordering and (2) antibiotic orders for urinalyses and UCs in hospitalized adult patients.

Population

We conducted a prospective time series analysis (preintervention: September 2014 to June 2015; postintervention: September 2015 to June 2016) at a large tertiary medical center. All hospitalized patients ≥18 years old were eligible except those admitted to services requiring specialized ASB management (eg, leukemia and lymphoma, solid organ transplant, and obstetrics).¹ The study was declared quality improvement by the Johns Hopkins Institutional Review Board.

Intervention

In August 2015, we implemented a multifaceted intervention that included provider education and passive electronic CDS (supplementary Appendix 1 and supplementary Appendix 2). Materials were disseminated through hospital-wide computer workstation screensavers and a 1-page e-mailed newsletter to department of medicine clinicians. The CDS tool included simple informational messages recommending against urine testing without symptoms and against treating ASB; these messages accompanied electronic health record (EHR; Allscripts Sunrise Clinical Manager, Chicago, IL) orders for urinalysis, UC, and antibiotics commonly used within our institution to treat UTI (cefazolin, cephalexin, ceftriaxone, trimethoprim-sulfamethoxazole, nitrofurantoin, and ciprofloxacin). The information was displayed automatically when orders for these tests and antibiotics were selected; provider acknowledgment was not required to proceed.

Data Collection

The services within our hospital are geographically located. We collected orders for urinalysis, UC, and the associated antibiotics for all units except those housing patients excluded from our study. As the CDS tool appeared only in the inpatient EHR, only postadmission orders were included, excluding emergency department orders. For admissions with multiple urinalyses, urinalysis orders placed ≥72 hours apart were eligible. Only antibiotics ordered for ≥24 hours were included, excluding on-call and 1-time antibiotic orders.

Our approach to data collection attempted to model a clinician’s decision-making pathway from (1) ordering a urinalysis, to (2) ordering a UC in response to a urinalysis result, to (3) ordering antibiotics in response to a urinalysis or UC result. We focused on order placement rather than results to prioritize avoiding testing in asymptomatic patients, as our institution does not require positive urinalyses for UC testing (reflex testing). Urinalyses resulted within 1 to 2 hours, allowing for clinicians to quickly order UCs after urinalysis result review. Urinalysis and UC orders per monthly admissions were defined as (1) urinalyses, (2) UCs, (3) simultaneous urinalysis and UC (within 1 hour of each other), and (4) UCs ordered 1 to 24 hours after urinalysis. We also analyzed the following antibiotic orders per monthly admissions: (1) simultaneous urinalysis and antibiotic orders, (2) antibiotics ordered 1 to 24 hours after urinalysis order, and (3) antibiotics ordered within 24 hours of the UC result.

Outcome Measures

All outcome measures were calculated as the change over time per total monthly admissions in the preintervention and postintervention periods. In addition to symptoms, urinalysis is a critical, measurable early step in determining the presence of ASB. Therefore, the primary outcome measure was the postintervention change in monthly urinalysis orders, and the secondary outcome measure was the postintervention change in monthly UC orders. Additional outcome measures included monthly postintervention changes in (1) UC ordered 1 to 24 hours after urinalyses, (2) urinalyses and antibiotics ordered simultaneously, (3) antibiotic orders within 1 to 24 hours of urinalyses, and (4) antibiotics ordered within 24 hours of UC result.

Statistical Analysis

Statistical analyses were performed by using Stata (version 14.2; StataCorp LLC, College Station, TX). An interrupted time series analysis was performed to compare the change in orders per 100 monthly admissions in preintervention and postintervention periods. To do this, we created 2 separate segmented linear regression models for each dependent variable, pre- and postintervention. Normality was assumed because of large numbers. Rate differences per 100 monthly admissions are also calculated as the total number of orders divided by the total number of admissions in postintervention and preintervention periods with Mantel-Haenszel estimators. Differences were considered statistically significant at P ≤ .05.

A multifaceted but simple bundle of CDS and provider education reduced UC testing but not urinalyses in a large tertiary care hospital. The bundle also reduced antibiotic ordering in response to urinalyses as well as antibiotic ordering in response to UC results.

Other in-hospital CDS tools to decrease ASB treatment have focused only on ICUs.^9,10 Our intervention was evaluated hospital-wide and included urinalyses and UCs. Our intervention was clinician directed and not laboratory directed, such as a positive urinalysis reflexing to a UC. Simultaneous urinalysis and UC testing may lead to ASB treatment, as clinicians treat the positive UC and ignore the negative urinalysis.^11,12 Therefore, we focused on UCs being sent in response to urinalyses.

We chose to focus on laboratory testing data instead of administrative diagnoses for UTI. The sensitivity of administrative data to determine similar conditions such as catheter-associated UTIs is low (0%).¹³

Our single-center study may not be generalizable to other settings. We did not include emergency department patients, as this location used a different EHR. In addition, given the 600,000 yearly hospital admissions, it was impractical to assess the appropriateness of each antibiotic-based documentation of symptoms. Instead of focusing on symptoms of ASB or UTI diagnoses, we focused on ordering urinalysis, UC, and antibiotics. In investigating the antibiotics most frequently used to treat UTI in our hospital, we may have both missed some patients who were treated with other antibiotics for ASB (eg, 4th generation cephalosporins, penicillins, carbapenems, etc) and captured patients receiving antibiotics for indications other than UTI (eg, pneumonia). In our focus on overall ordering practices across a hospital, we did not capture data on bladder catheterization status or the predominant organism seen in UC. At the time of the intervention, the laboratory did not have the resources for urinalysis testing reflexing to UC. However, our intervention did not prevent ordering simultaneous urinalysis and UC in symptomatic patients in general or urosepsis in particular. With only 12 total time points, the interrupted time series analysis may have been underpowered.¹⁴ We also do not know if the intervention’s effect would decay over time.

Although the intervention took very little staff time and resources, alert fatigue was a risk.¹⁵ We attempted to mitigate this alert fatigue by making the CDS passive (in the form of a brief informational message) with no provider action required. In conversations with providers in our institution, there has been dissatisfaction with alerts requiring action, as these are thought to be overly intrusive. We are also not clear on which element of the intervention bundle (ie, the CDS or the educational intervention) may have had more of an impact, as the elements of the intervention bundle were rolled out simultaneously. It is possible and even probable that both elements are needed to raise awareness of the problem. Also, as our EHR required all interventions to be rolled out hospital-wide simultaneously, we were unable to randomize certain floors or providers to the CDS portion of the intervention bundle. Other analyses including the type of hospital unit were beyond the scope of this brief report.

Our intervention bundle was associated with reduced UC orders and reduced antibiotics ordered after urinalyses. If a provider does not know there is bacteriuria, then the provider will not be tempted to order antibiotics. This easily implementable bundle may play an important role as an antimicrobial stewardship strategy for ASB.

Acknowledgments

The authors acknowledge the support of Erin Fanning, BS, and Angel Florentin, BS, in providing data for analysis. SCK received funding from the Johns Hopkins Institute for Clinical and Translational Research (ICTR), which is funded in part by grant number KL2TR001077 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research. These contents are solely the responsibility of the authors and do not necessarily represent the official view of the Johns Hopkins ICTR, NCATS, or NIH. We also acknowledge support from the Centers for Disease Control and Prevention’s Prevention Epicenter Program Q8377 (collaborative agreement U54 CK000447 to SEC). SEC has received support for consulting from Novartis and Theravance, and her institution has received a grant from Pfizer Grants for Learning and Change/The Joint Commission. This work was supported by the NIH T32 HL116275 to NC. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Disclosure

No conflicts of interest have been reported by any author.

The “Things We Do for No Reason” series reviews practices which have become common parts of hospital care but which may provide little value to our patients. Practices reviewed in the TWDFNR series do not represent “black and white” conclusions or clinical practice standards, but are meant as a starting place for research and active discussions among hospitalists and patients. We invite you to be part of that discussion. https://www.choosingwisely.org/

A 62-year-old woman with type 2 diabetes mellitus, systemic hypertension, coronary artery disease, and obesity is admitted for AKI found on routine laboratory testing. She has been taking amoxicillin and doxycycline for left leg cellulitis the past 5 days, but improvement has been minimal. On admission, blood pressure is 120/74 mm Hg, and heart rate is 89 beats per minute. Serum creatinine level is increased, from 0.7 mg/dL at baseline to 3.6 mg/dL on admission. Complete urinalysis reveals 1+ protein and presence of white blood cells and isormorphic red blood cells. No casts or crystals are seen. Given the possibility of AIN, UE testing is ordered. UEs are positive at 25%. Does this result significantly increase the patient’s posttest probability of having AIN?

WHY YOU MIGHT THINK ORDERING URINE EOSINOPHILS IN THE EVALUATION OF AIN IS HELPFUL

AKI occurs in more than 1 in 5 hospitalizations and is associated with a more than 4-fold increased likelihood of in-hospital mortality at 21 days.¹ AIN is an important cause of AKI and has been found in 6% to 30% of AKI patients who had biopsies performed.^2-4 AIN is characterized by infiltration of inflammatory cells in the kidney interstitium and is more commonly caused by drugs, especially beta-lactam antibiotics, and less commonly by autoimmune or systemic diseases and infections. As the signs and symptoms of AIN are nonspecific, and the gold-standard test is renal biopsy, diagnosticians have sought a noninvasive test, such as UEs.

In 1978, Galpin et al.⁵ found that UEs comprised 10% to 60% of urine white blood cells in 9 of 9 patients with methicillin-induced interstitial nephritis; 6 of the 9 had biopsy-proven AIN. In 1980, Linton et al.⁶ found UEs in 6 of 9 patients with drug-induced AIN; 8 of the 9 had biopsy-proven AIN. In 1986, Nolan et al.⁷ reported that, compared with Wright stain, Hansel stain was more sensitive in visualizing UEs; they did not use biopsy for confirmation. Wright-stain detection of UEs is limited by the variable staining characteristics of “eosinophilic” granules in body fluids other than blood. With Hansel stain, UEs are readily identified by their brilliant red-pink granules. These 3 small studies helped make UEs the go-to noninvasive test for assessing for AIN.⁸

WHY THERE IS LITTLE REASON TO ORDER URINE EOSINOPHILS IN PATIENTS WITH SUSPICION FOR AIN

While initial studies indicated UEs might be diagnostically helpful, subsequent studies did not. In 1985, Corwin et al.⁹ used Wright stain and found UEs in 65 of 470 adults with AKI. Only 9 (14%) of the 65 had a diagnosis of AIN, which was made mostly on clinical grounds. These findings showed that UEs were produced by other renal or urinary tract abnormalities, such as urinary tract infections, acute tubular necrosis, and glomerulonephritis. In a second study, Corwin et al.¹⁰ found that Hansel stain (vs Wright stain) improved the sensitivity of UEs for AIN diagnosis, from 25% to 62.5%. Sensitivity was improved at the expense of specificity, as Hansel stain was positive in other diagnoses as well. The AIN diagnosis was not confirmed by kidney biopsy in the large majority of patients in this study. Lack of confirmation by biopsy, the gold-standard diagnostic test, was a methodologic flaw of this study and others.

Sutton¹¹ reviewed data from 10 studies and found AIN could not be reliably excluded in the absence of UEs (only 19 of 32 biopsy-confirmed AIN cases had UEs present). In addition, Ruffing et al.¹² used Hansel stain and concluded that the positive predictive value of UEs was inadequate in diagnosing AIN. Only 6 of their 15 patients with AIN had positive UEs. Urine eosinophils were also present in patients with other diagnoses (glomerulonephritis, chronic kidney disease, acute pyelonephritis, prerenal azotemia). Like many other investigators, Ruffing et al. made the AIN diagnosis on clinical grounds in the large majority of cases.

Muriithi et al.¹³ reported similarly negative results in their retrospective AKI study involving 566 Mayo Clinic patients and spanning almost 2 decades. The study included patients who underwent both Hansel-stain UE testing and kidney biopsy within a week of each other. Only 28 (30%) of 91 biopsy-proven AIN cases were positive for UEs. Using the 1% cutoff for a positive UE test yielded only 30.8% sensitivity and 68.2% specificity. Using the 5% cutoff increased specificity to 91.2%, at the expense of sensitivity (19.2%); positive predictive value improved to only 30%, and negative predictive value remained relatively unchanged, at 85.6%. In short, Muriithi et al. found that UE testing had no utility in AIN diagnosis.

In summary, initial studies, such as those by Corwin et al,^9,10 supported the conclusion that UEs are useful in AIN diagnosis but had questionable validity owing to methodologic issues, including small sample size and lack of biopsy confirmation of AIN. On the other hand, more recent studies, such as the one conducted by Muriithi et al.,¹³ had larger sample sizes and biopsy-proven diagnoses and confirmed the poor diagnostic value of UEs in AIN.

The poor sensitivity and specificity of UE tests can have important consequences. A false positive test may cause the clinician to incorrectly diagnose the patient with AIN and prompt the clinician to remove medications that may be vitally important. The clinician may also consider treating the patient with steroids empirically. A false negative test may inappropriately reassure the clinician that the patient does not have AIN and does not need cessation of the culprit drug. This may also lead the clinician to forego a necessary kidney biopsy.

WHAT YOU SHOULD DO INSTEAD

A history of recent exposure to a classic offending drug (eg, beta-lactam, proton pump inhibitor, nonsteroidal anti-inflammatory drug) in combination with the classic triad of fever, rash, and peripheral eosinophilia suggests an AIN diagnosis. However, less than 5% to 10% of patients present with this triad.^14,15 Regardless of the triad’s presence, if other causes of AKI have been excluded, stopping a potential offending agent and monitoring for improvement are recommended. If a culprit drug cannot be safely discontinued, renal biopsy may be necessary for confirmation of the diagnosis. Moreover, if kidney function continues to deteriorate, a nephrology consultation may be warranted for guidance on the risks and benefits of performing a kidney biopsy to confirm the diagnosis and/or the use of corticosteroids.

• Urine eosinophils should not be used in the diagnosis of AIN.
• The clinical diagnosis of drug-associated AIN should be based on excluding other possible likely etiologies of AKI and confirming the history of drug exposure. This is reinforced when kidney function improves upon discontinuation of offending agent.
• Kidney biopsy is the gold standard for AIN and should be performed if the clinical picture is unclear or the renal function is not improving upon discontinuation of offending agent.

Since the mid-1980s, studies have found that UEs are too insensitive and nonspecific to confirm or exclude the diagnosis of AIN in patients with AKI (Table). UEs are seen in other AKI etiologies, such as pyelonephritis, acute tubular necrosis, atheroembolic renal disease, and glomerulonephritis. Current evidence-based medicine does not support use of UEs as a biomarker for AIN. False-positive and false-negative results confuse the overall picture and result either in discontinuation of important medications and unnecessary steroid treatment or in delayed removal of a culprit medication.¹⁶

Our case’s positive UE test does not affect the posttest probability that our patient has AIN. Presence of a culprit drug and absence of clinical data suggesting an alternative diagnosis would lead most clinicians to change antibiotic therapy and observe for improvement in renal function.

Disclosure

Nothing to report.

Do you think this is a low-value practice? Is this truly a “Thing We Do for No Reason?” Share what you do in your practice and join in the conversation online by retweeting it on Twitter (#TWDFNR) and Liking It on Facebook. We invite you to propose ideas for other “Things We Do for No Reason” topics by emailing [email protected].

The “Things We Do for No Reason” series reviews practices which have become common parts of hospital care but which may provide little value to our patients. Practices reviewed in the TWDFNR series do not represent “black and white” conclusions or clinical practice standards, but are meant as a starting place for research and active discussions among hospitalists and patients. We invite you to be part of that discussion. https://www.choosingwisely.org/

A 62-year-old woman with type 2 diabetes mellitus, systemic hypertension, coronary artery disease, and obesity is admitted for AKI found on routine laboratory testing. She has been taking amoxicillin and doxycycline for left leg cellulitis the past 5 days, but improvement has been minimal. On admission, blood pressure is 120/74 mm Hg, and heart rate is 89 beats per minute. Serum creatinine level is increased, from 0.7 mg/dL at baseline to 3.6 mg/dL on admission. Complete urinalysis reveals 1+ protein and presence of white blood cells and isormorphic red blood cells. No casts or crystals are seen. Given the possibility of AIN, UE testing is ordered. UEs are positive at 25%. Does this result significantly increase the patient’s posttest probability of having AIN?

WHY YOU MIGHT THINK ORDERING URINE EOSINOPHILS IN THE EVALUATION OF AIN IS HELPFUL

AKI occurs in more than 1 in 5 hospitalizations and is associated with a more than 4-fold increased likelihood of in-hospital mortality at 21 days.¹ AIN is an important cause of AKI and has been found in 6% to 30% of AKI patients who had biopsies performed.^2-4 AIN is characterized by infiltration of inflammatory cells in the kidney interstitium and is more commonly caused by drugs, especially beta-lactam antibiotics, and less commonly by autoimmune or systemic diseases and infections. As the signs and symptoms of AIN are nonspecific, and the gold-standard test is renal biopsy, diagnosticians have sought a noninvasive test, such as UEs.

In 1978, Galpin et al.⁵ found that UEs comprised 10% to 60% of urine white blood cells in 9 of 9 patients with methicillin-induced interstitial nephritis; 6 of the 9 had biopsy-proven AIN. In 1980, Linton et al.⁶ found UEs in 6 of 9 patients with drug-induced AIN; 8 of the 9 had biopsy-proven AIN. In 1986, Nolan et al.⁷ reported that, compared with Wright stain, Hansel stain was more sensitive in visualizing UEs; they did not use biopsy for confirmation. Wright-stain detection of UEs is limited by the variable staining characteristics of “eosinophilic” granules in body fluids other than blood. With Hansel stain, UEs are readily identified by their brilliant red-pink granules. These 3 small studies helped make UEs the go-to noninvasive test for assessing for AIN.⁸

WHY THERE IS LITTLE REASON TO ORDER URINE EOSINOPHILS IN PATIENTS WITH SUSPICION FOR AIN

While initial studies indicated UEs might be diagnostically helpful, subsequent studies did not. In 1985, Corwin et al.⁹ used Wright stain and found UEs in 65 of 470 adults with AKI. Only 9 (14%) of the 65 had a diagnosis of AIN, which was made mostly on clinical grounds. These findings showed that UEs were produced by other renal or urinary tract abnormalities, such as urinary tract infections, acute tubular necrosis, and glomerulonephritis. In a second study, Corwin et al.¹⁰ found that Hansel stain (vs Wright stain) improved the sensitivity of UEs for AIN diagnosis, from 25% to 62.5%. Sensitivity was improved at the expense of specificity, as Hansel stain was positive in other diagnoses as well. The AIN diagnosis was not confirmed by kidney biopsy in the large majority of patients in this study. Lack of confirmation by biopsy, the gold-standard diagnostic test, was a methodologic flaw of this study and others.

Sutton¹¹ reviewed data from 10 studies and found AIN could not be reliably excluded in the absence of UEs (only 19 of 32 biopsy-confirmed AIN cases had UEs present). In addition, Ruffing et al.¹² used Hansel stain and concluded that the positive predictive value of UEs was inadequate in diagnosing AIN. Only 6 of their 15 patients with AIN had positive UEs. Urine eosinophils were also present in patients with other diagnoses (glomerulonephritis, chronic kidney disease, acute pyelonephritis, prerenal azotemia). Like many other investigators, Ruffing et al. made the AIN diagnosis on clinical grounds in the large majority of cases.

Muriithi et al.¹³ reported similarly negative results in their retrospective AKI study involving 566 Mayo Clinic patients and spanning almost 2 decades. The study included patients who underwent both Hansel-stain UE testing and kidney biopsy within a week of each other. Only 28 (30%) of 91 biopsy-proven AIN cases were positive for UEs. Using the 1% cutoff for a positive UE test yielded only 30.8% sensitivity and 68.2% specificity. Using the 5% cutoff increased specificity to 91.2%, at the expense of sensitivity (19.2%); positive predictive value improved to only 30%, and negative predictive value remained relatively unchanged, at 85.6%. In short, Muriithi et al. found that UE testing had no utility in AIN diagnosis.

In summary, initial studies, such as those by Corwin et al,^9,10 supported the conclusion that UEs are useful in AIN diagnosis but had questionable validity owing to methodologic issues, including small sample size and lack of biopsy confirmation of AIN. On the other hand, more recent studies, such as the one conducted by Muriithi et al.,¹³ had larger sample sizes and biopsy-proven diagnoses and confirmed the poor diagnostic value of UEs in AIN.

The poor sensitivity and specificity of UE tests can have important consequences. A false positive test may cause the clinician to incorrectly diagnose the patient with AIN and prompt the clinician to remove medications that may be vitally important. The clinician may also consider treating the patient with steroids empirically. A false negative test may inappropriately reassure the clinician that the patient does not have AIN and does not need cessation of the culprit drug. This may also lead the clinician to forego a necessary kidney biopsy.

WHAT YOU SHOULD DO INSTEAD

A history of recent exposure to a classic offending drug (eg, beta-lactam, proton pump inhibitor, nonsteroidal anti-inflammatory drug) in combination with the classic triad of fever, rash, and peripheral eosinophilia suggests an AIN diagnosis. However, less than 5% to 10% of patients present with this triad.^14,15 Regardless of the triad’s presence, if other causes of AKI have been excluded, stopping a potential offending agent and monitoring for improvement are recommended. If a culprit drug cannot be safely discontinued, renal biopsy may be necessary for confirmation of the diagnosis. Moreover, if kidney function continues to deteriorate, a nephrology consultation may be warranted for guidance on the risks and benefits of performing a kidney biopsy to confirm the diagnosis and/or the use of corticosteroids.

• Urine eosinophils should not be used in the diagnosis of AIN.
• The clinical diagnosis of drug-associated AIN should be based on excluding other possible likely etiologies of AKI and confirming the history of drug exposure. This is reinforced when kidney function improves upon discontinuation of offending agent.
• Kidney biopsy is the gold standard for AIN and should be performed if the clinical picture is unclear or the renal function is not improving upon discontinuation of offending agent.

Since the mid-1980s, studies have found that UEs are too insensitive and nonspecific to confirm or exclude the diagnosis of AIN in patients with AKI (Table). UEs are seen in other AKI etiologies, such as pyelonephritis, acute tubular necrosis, atheroembolic renal disease, and glomerulonephritis. Current evidence-based medicine does not support use of UEs as a biomarker for AIN. False-positive and false-negative results confuse the overall picture and result either in discontinuation of important medications and unnecessary steroid treatment or in delayed removal of a culprit medication.¹⁶

Our case’s positive UE test does not affect the posttest probability that our patient has AIN. Presence of a culprit drug and absence of clinical data suggesting an alternative diagnosis would lead most clinicians to change antibiotic therapy and observe for improvement in renal function.

Disclosure

Nothing to report.

Do you think this is a low-value practice? Is this truly a “Thing We Do for No Reason?” Share what you do in your practice and join in the conversation online by retweeting it on Twitter (#TWDFNR) and Liking It on Facebook. We invite you to propose ideas for other “Things We Do for No Reason” topics by emailing [email protected].

The “Things We Do for No Reason” series reviews practices which have become common parts of hospital care but which may provide little value to our patients. Practices reviewed in the TWDFNR series do not represent “black and white” conclusions or clinical practice standards, but are meant as a starting place for research and active discussions among hospitalists and patients. We invite you to be part of that discussion. https://www.choosingwisely.org/

A 62-year-old woman with type 2 diabetes mellitus, systemic hypertension, coronary artery disease, and obesity is admitted for AKI found on routine laboratory testing. She has been taking amoxicillin and doxycycline for left leg cellulitis the past 5 days, but improvement has been minimal. On admission, blood pressure is 120/74 mm Hg, and heart rate is 89 beats per minute. Serum creatinine level is increased, from 0.7 mg/dL at baseline to 3.6 mg/dL on admission. Complete urinalysis reveals 1+ protein and presence of white blood cells and isormorphic red blood cells. No casts or crystals are seen. Given the possibility of AIN, UE testing is ordered. UEs are positive at 25%. Does this result significantly increase the patient’s posttest probability of having AIN?

WHY YOU MIGHT THINK ORDERING URINE EOSINOPHILS IN THE EVALUATION OF AIN IS HELPFUL

AKI occurs in more than 1 in 5 hospitalizations and is associated with a more than 4-fold increased likelihood of in-hospital mortality at 21 days.¹ AIN is an important cause of AKI and has been found in 6% to 30% of AKI patients who had biopsies performed.^2-4 AIN is characterized by infiltration of inflammatory cells in the kidney interstitium and is more commonly caused by drugs, especially beta-lactam antibiotics, and less commonly by autoimmune or systemic diseases and infections. As the signs and symptoms of AIN are nonspecific, and the gold-standard test is renal biopsy, diagnosticians have sought a noninvasive test, such as UEs.

In 1978, Galpin et al.⁵ found that UEs comprised 10% to 60% of urine white blood cells in 9 of 9 patients with methicillin-induced interstitial nephritis; 6 of the 9 had biopsy-proven AIN. In 1980, Linton et al.⁶ found UEs in 6 of 9 patients with drug-induced AIN; 8 of the 9 had biopsy-proven AIN. In 1986, Nolan et al.⁷ reported that, compared with Wright stain, Hansel stain was more sensitive in visualizing UEs; they did not use biopsy for confirmation. Wright-stain detection of UEs is limited by the variable staining characteristics of “eosinophilic” granules in body fluids other than blood. With Hansel stain, UEs are readily identified by their brilliant red-pink granules. These 3 small studies helped make UEs the go-to noninvasive test for assessing for AIN.⁸

WHY THERE IS LITTLE REASON TO ORDER URINE EOSINOPHILS IN PATIENTS WITH SUSPICION FOR AIN

While initial studies indicated UEs might be diagnostically helpful, subsequent studies did not. In 1985, Corwin et al.⁹ used Wright stain and found UEs in 65 of 470 adults with AKI. Only 9 (14%) of the 65 had a diagnosis of AIN, which was made mostly on clinical grounds. These findings showed that UEs were produced by other renal or urinary tract abnormalities, such as urinary tract infections, acute tubular necrosis, and glomerulonephritis. In a second study, Corwin et al.¹⁰ found that Hansel stain (vs Wright stain) improved the sensitivity of UEs for AIN diagnosis, from 25% to 62.5%. Sensitivity was improved at the expense of specificity, as Hansel stain was positive in other diagnoses as well. The AIN diagnosis was not confirmed by kidney biopsy in the large majority of patients in this study. Lack of confirmation by biopsy, the gold-standard diagnostic test, was a methodologic flaw of this study and others.

Sutton¹¹ reviewed data from 10 studies and found AIN could not be reliably excluded in the absence of UEs (only 19 of 32 biopsy-confirmed AIN cases had UEs present). In addition, Ruffing et al.¹² used Hansel stain and concluded that the positive predictive value of UEs was inadequate in diagnosing AIN. Only 6 of their 15 patients with AIN had positive UEs. Urine eosinophils were also present in patients with other diagnoses (glomerulonephritis, chronic kidney disease, acute pyelonephritis, prerenal azotemia). Like many other investigators, Ruffing et al. made the AIN diagnosis on clinical grounds in the large majority of cases.

Muriithi et al.¹³ reported similarly negative results in their retrospective AKI study involving 566 Mayo Clinic patients and spanning almost 2 decades. The study included patients who underwent both Hansel-stain UE testing and kidney biopsy within a week of each other. Only 28 (30%) of 91 biopsy-proven AIN cases were positive for UEs. Using the 1% cutoff for a positive UE test yielded only 30.8% sensitivity and 68.2% specificity. Using the 5% cutoff increased specificity to 91.2%, at the expense of sensitivity (19.2%); positive predictive value improved to only 30%, and negative predictive value remained relatively unchanged, at 85.6%. In short, Muriithi et al. found that UE testing had no utility in AIN diagnosis.

In summary, initial studies, such as those by Corwin et al,^9,10 supported the conclusion that UEs are useful in AIN diagnosis but had questionable validity owing to methodologic issues, including small sample size and lack of biopsy confirmation of AIN. On the other hand, more recent studies, such as the one conducted by Muriithi et al.,¹³ had larger sample sizes and biopsy-proven diagnoses and confirmed the poor diagnostic value of UEs in AIN.

The poor sensitivity and specificity of UE tests can have important consequences. A false positive test may cause the clinician to incorrectly diagnose the patient with AIN and prompt the clinician to remove medications that may be vitally important. The clinician may also consider treating the patient with steroids empirically. A false negative test may inappropriately reassure the clinician that the patient does not have AIN and does not need cessation of the culprit drug. This may also lead the clinician to forego a necessary kidney biopsy.

WHAT YOU SHOULD DO INSTEAD

A history of recent exposure to a classic offending drug (eg, beta-lactam, proton pump inhibitor, nonsteroidal anti-inflammatory drug) in combination with the classic triad of fever, rash, and peripheral eosinophilia suggests an AIN diagnosis. However, less than 5% to 10% of patients present with this triad.^14,15 Regardless of the triad’s presence, if other causes of AKI have been excluded, stopping a potential offending agent and monitoring for improvement are recommended. If a culprit drug cannot be safely discontinued, renal biopsy may be necessary for confirmation of the diagnosis. Moreover, if kidney function continues to deteriorate, a nephrology consultation may be warranted for guidance on the risks and benefits of performing a kidney biopsy to confirm the diagnosis and/or the use of corticosteroids.

• Urine eosinophils should not be used in the diagnosis of AIN.
• The clinical diagnosis of drug-associated AIN should be based on excluding other possible likely etiologies of AKI and confirming the history of drug exposure. This is reinforced when kidney function improves upon discontinuation of offending agent.
• Kidney biopsy is the gold standard for AIN and should be performed if the clinical picture is unclear or the renal function is not improving upon discontinuation of offending agent.

Since the mid-1980s, studies have found that UEs are too insensitive and nonspecific to confirm or exclude the diagnosis of AIN in patients with AKI (Table). UEs are seen in other AKI etiologies, such as pyelonephritis, acute tubular necrosis, atheroembolic renal disease, and glomerulonephritis. Current evidence-based medicine does not support use of UEs as a biomarker for AIN. False-positive and false-negative results confuse the overall picture and result either in discontinuation of important medications and unnecessary steroid treatment or in delayed removal of a culprit medication.¹⁶

Our case’s positive UE test does not affect the posttest probability that our patient has AIN. Presence of a culprit drug and absence of clinical data suggesting an alternative diagnosis would lead most clinicians to change antibiotic therapy and observe for improvement in renal function.

Disclosure

Nothing to report.

Do you think this is a low-value practice? Is this truly a “Thing We Do for No Reason?” Share what you do in your practice and join in the conversation online by retweeting it on Twitter (#TWDFNR) and Liking It on Facebook. We invite you to propose ideas for other “Things We Do for No Reason” topics by emailing [email protected].