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Low preconception complement levels linked to adverse pregnancy outcomes in antiphospholipid syndrome
Low levels of C3 and C4 in the 6 months prior to pregnancy were associated with several gestational and maternal complications and resulted in...
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Hypoglycemia awareness program helps tricky-to-treat T1D
New psychoeducation program tackles problematic type 1 diabetes hypoglycemia awareness, reducing severe hypoglycemia with added mental health...
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Cell therapy promising as long-term limb-saving treatment in diabetes
Fewer amputations were needed at 5 years in patients with diabetic foot and critical limb-threatening ischemia, compared with conservative...
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Retinopathy risk higher in young-onset T2D, more so in men
Gender differences in the prevalence of retinopathy have been seen in a large Norwegian population of primary care patients with type 2 diabetes...
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‘Metabolically healthy obesity’ tied to substantial heart risk
There was an increased risk for both new-onset heart failure and atrial fibrillation in people who were obese with no metabolic abnormalities.
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Heart failure hospitalization risk lower with SGLT2 inhibitors than GLP-1 RAs
SGLT2 inhibitor versus GLP-1 RA use was associated with a significantly lower rate of hospitalization for heart failure in people with diabetes....
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Early vs. late TNFi switch in AS patients associated with different risk factors
Different factors were associated with switching an initial TNF inhibitor within 2 years versus after 2 years of treatment.
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Real-world data generate debate on definition of flare in axial spondyloarthritis
Changes in the Bath Ankylosing Spondyloarthritis Disease Activity Index could be used to monitor patient-reported flares in axial...
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Targeting IL-23 could still be important for axial spondyloarthritis treatment
Results of a systematic review and meta-analysis corroborate negative trial findings for IL-23 but hint at some early benefit with risankizumab....
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csDMARDs could add to TNF inhibitors’ benefits in SpA
EuroSpA Research Collaboration data hint at better retention and remission rates with csDMARD-TNFi cotherapy versus TNFi alone in...
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Biologic benefit in psoriasis might extend to arthritis prevention
People with psoriasis had a lower risk for psoriatic arthritis if they had been treated with a biologic than if they had not, based on a study of...
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Vertebral fractures still a risk with low-dose oral glucocorticoids for RA
Vertebral, not other, osteoporotic fractures were increased in current versus past users of low-dose steroids in a retrospective cohort study.
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Pharmacovigilance data implicate three new drugs in ANCA-associated vasculitis
Mirabegron, sofosbuvir, and nintedanib join a list of 12 other drugs that have been linked to an overreporting of drug-associated ANCA vasculitis...
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TNF inhibitors have delayed effect on spondyloarthritis radiographic progression
It could take 2-4 years before plain radiographs show any sign of a benefit on the spine or sacroiliac joints.
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Mavrilimumab may aid severe COVID-19 recovery
The granulocyte/macrophage-colony stimulating factor (GM-CSF) blocker reduced the need for mechanical ventilation and death by day 29 versus...