Nephrology

WASHINGTON – Think cerebrovascular fibromuscular dysplasia in a middle-aged woman who presents with a complaint of pulsatile tinnitus.

That’s the take-home message from a new analysis of the United States Registry for Fibromuscular Dysplasia. The data highlight pulsatile tinnitus as an important clinical manifestation of fibromuscular dysplasia (FMD). Indeed, it was a presenting symptom in one-third of 720 patients included in the national registry, Dr. Redah Z. Mahmood reported at the annual meeting of the American College of Cardiology.

FMD is a nonatherosclerotic, noninflammatory form of vascular disease. It is predominantly a disease of middle-aged women: 91% of patients in the registry were women, as were 98% of patients who presented with pulsatile tinnitus. The mean age at symptom onset for registry participants was 48.8 years, although on average another 4.2 years passed before FMD was diagnosed on the basis of angiography or noninvasive imaging, noted Dr. Mahmood of the Cleveland Clinic.

FMD presents a formidable diagnostic challenge because of its potential to appear in virtually any arterial vascular bed and its lack of specific symptoms. The FMD registry was formed in 2008 in an effort to shed new light on the disorder. The association with pulsatile tinnitus is particularly helpful in raising the index of suspicion, he continued.

Patients with pulsatile tinnitus as a presenting symptom of FMD were more likely than those without that complaint to have frequent headaches, by a margin of 71%-47%. Nearly half of FMD patients with pulsatile tinnitus reported neck pain, compared with 19% without pulsatile tinnitus. Dizziness, transient ischemic attacks, cervical bruit, and Horner syndrome also were significantly more common in the pulsatile tinnitus group. This cluster of symptoms reflects the pulsatile tinnitus group’s increased prevalence of FMD of the medial fibroplasia type involving the extracranial carotid and vertebral artery beds. Patients with pulsatile tinnitus were not more likely, however, to present with stroke, which was a presenting symptom in only about 8% of patients.

Patients with pulsatile tinnitus had a reduced likelihood of renal and mesenteric involvement. Fifty-three percent of them had hypertension, compared with 67% of FMD patients without pulsatile tinnitus.

Thirty-two percent of FMD patients with pulsatile tinnitus had a history of an anxiety disorder, a rate twice that of patients without pulsatile tinnitus. Intriguingly, 84% of patients with pulsatile tinnitus had a history of use of oral contraceptives or hormone replacement therapy, compared with 56% of those without pulsatile tinnitus.

This study was sponsored by the Fibromuscular Dysplasia Study of America, a nonprofit organization. Dr. Mahmood reported having no financial conflicts.

[email protected]

WASHINGTON – Think cerebrovascular fibromuscular dysplasia in a middle-aged woman who presents with a complaint of pulsatile tinnitus.

That’s the take-home message from a new analysis of the United States Registry for Fibromuscular Dysplasia. The data highlight pulsatile tinnitus as an important clinical manifestation of fibromuscular dysplasia (FMD). Indeed, it was a presenting symptom in one-third of 720 patients included in the national registry, Dr. Redah Z. Mahmood reported at the annual meeting of the American College of Cardiology.

FMD is a nonatherosclerotic, noninflammatory form of vascular disease. It is predominantly a disease of middle-aged women: 91% of patients in the registry were women, as were 98% of patients who presented with pulsatile tinnitus. The mean age at symptom onset for registry participants was 48.8 years, although on average another 4.2 years passed before FMD was diagnosed on the basis of angiography or noninvasive imaging, noted Dr. Mahmood of the Cleveland Clinic.

FMD presents a formidable diagnostic challenge because of its potential to appear in virtually any arterial vascular bed and its lack of specific symptoms. The FMD registry was formed in 2008 in an effort to shed new light on the disorder. The association with pulsatile tinnitus is particularly helpful in raising the index of suspicion, he continued.

Patients with pulsatile tinnitus as a presenting symptom of FMD were more likely than those without that complaint to have frequent headaches, by a margin of 71%-47%. Nearly half of FMD patients with pulsatile tinnitus reported neck pain, compared with 19% without pulsatile tinnitus. Dizziness, transient ischemic attacks, cervical bruit, and Horner syndrome also were significantly more common in the pulsatile tinnitus group. This cluster of symptoms reflects the pulsatile tinnitus group’s increased prevalence of FMD of the medial fibroplasia type involving the extracranial carotid and vertebral artery beds. Patients with pulsatile tinnitus were not more likely, however, to present with stroke, which was a presenting symptom in only about 8% of patients.

Patients with pulsatile tinnitus had a reduced likelihood of renal and mesenteric involvement. Fifty-three percent of them had hypertension, compared with 67% of FMD patients without pulsatile tinnitus.

Thirty-two percent of FMD patients with pulsatile tinnitus had a history of an anxiety disorder, a rate twice that of patients without pulsatile tinnitus. Intriguingly, 84% of patients with pulsatile tinnitus had a history of use of oral contraceptives or hormone replacement therapy, compared with 56% of those without pulsatile tinnitus.

This study was sponsored by the Fibromuscular Dysplasia Study of America, a nonprofit organization. Dr. Mahmood reported having no financial conflicts.

[email protected]

WASHINGTON – Think cerebrovascular fibromuscular dysplasia in a middle-aged woman who presents with a complaint of pulsatile tinnitus.

That’s the take-home message from a new analysis of the United States Registry for Fibromuscular Dysplasia. The data highlight pulsatile tinnitus as an important clinical manifestation of fibromuscular dysplasia (FMD). Indeed, it was a presenting symptom in one-third of 720 patients included in the national registry, Dr. Redah Z. Mahmood reported at the annual meeting of the American College of Cardiology.

FMD is a nonatherosclerotic, noninflammatory form of vascular disease. It is predominantly a disease of middle-aged women: 91% of patients in the registry were women, as were 98% of patients who presented with pulsatile tinnitus. The mean age at symptom onset for registry participants was 48.8 years, although on average another 4.2 years passed before FMD was diagnosed on the basis of angiography or noninvasive imaging, noted Dr. Mahmood of the Cleveland Clinic.

FMD presents a formidable diagnostic challenge because of its potential to appear in virtually any arterial vascular bed and its lack of specific symptoms. The FMD registry was formed in 2008 in an effort to shed new light on the disorder. The association with pulsatile tinnitus is particularly helpful in raising the index of suspicion, he continued.

Patients with pulsatile tinnitus as a presenting symptom of FMD were more likely than those without that complaint to have frequent headaches, by a margin of 71%-47%. Nearly half of FMD patients with pulsatile tinnitus reported neck pain, compared with 19% without pulsatile tinnitus. Dizziness, transient ischemic attacks, cervical bruit, and Horner syndrome also were significantly more common in the pulsatile tinnitus group. This cluster of symptoms reflects the pulsatile tinnitus group’s increased prevalence of FMD of the medial fibroplasia type involving the extracranial carotid and vertebral artery beds. Patients with pulsatile tinnitus were not more likely, however, to present with stroke, which was a presenting symptom in only about 8% of patients.

Patients with pulsatile tinnitus had a reduced likelihood of renal and mesenteric involvement. Fifty-three percent of them had hypertension, compared with 67% of FMD patients without pulsatile tinnitus.

Thirty-two percent of FMD patients with pulsatile tinnitus had a history of an anxiety disorder, a rate twice that of patients without pulsatile tinnitus. Intriguingly, 84% of patients with pulsatile tinnitus had a history of use of oral contraceptives or hormone replacement therapy, compared with 56% of those without pulsatile tinnitus.

This study was sponsored by the Fibromuscular Dysplasia Study of America, a nonprofit organization. Dr. Mahmood reported having no financial conflicts.

[email protected]

Men whose benign prostate biopsy cores showed signs of chronic inflammation had more than twice the odds of high-grade prostate cancer, investigators reported online April 18 in Cancer Epidemiology, Biomarkers & Prevention.

The association existed even when prostate-specific antigen was low (less than 2 ng/mL at biopsy), suggesting that the results were not due to detection bias, said Dr. Bora Gurel of Johns Hopkins University, Baltimore, and his associates.

The nested case-control study included 191 patients with biopsy-proven prostate cancer and 209 cancer-free patients from the placebo arm of the Prostate Cancer Prevention Trial. To measure the presence and extent of inflammation, a pathologist who was blinded to case-control status examined stained tissue sections from benign areas of prostate biopsy cores. The presence of any inflammatory cells, both acute inflammatory cells and chronic inflammatory cells (cells with an appearance consistent with that of lymphocytes and macrophages) in the benign tissue for each biopsy core on each slide, were noted.

Signs of inflammation were found in at least one biopsy core in 78.2% of controls, 86.2% of cases overall, and 88.4% of high-grade cases. Most of the signs of inflammation in both controls and cases reflected chronic inflammation.

Men who had at least one biopsy core with inflammation had greater odds of a prostate cancer diagnosis (odds ratio, 1.78; 95% confidence interval, 1.04–3.06) than men who had zero cores with inflammation, and even greater odds of a high-grade diagnosis (OR, 2.24; 95% CI, 1.06-4.71), the researchers reported (Cancer Epidemiol. Biomarkers Prev. 2014 April 18 [doi: 10.1158/1055-9965.EPI-13-1126]).

But it was unclear if inflammation preceded cancer onset, because the biopsy cores were obtained to evaluate patients for prostate cancer, the investigators said.

The finding that inflammation, primarily chronic, in benign prostate tissue is associated with an increased odds of prostate cancer, and high-grade prostate cancer in particular, will inform the etiology of this disease, the investigators concluded.

"Identifying those men at highest risk of developing aggressive disease is the first step in being able to prevent lethal prostate cancer," they said. "Rather than targeting interventions to all healthy men, which may result in unintended harms, if causal, the findings from our work may allow preventive interventions to be targeted to those men who would benefit the most," they wrote.

The National Cancer Institute funded the study. The authors disclosed no relevant financial conflicts of interest.

Men whose benign prostate biopsy cores showed signs of chronic inflammation had more than twice the odds of high-grade prostate cancer, investigators reported online April 18 in Cancer Epidemiology, Biomarkers & Prevention.

The association existed even when prostate-specific antigen was low (less than 2 ng/mL at biopsy), suggesting that the results were not due to detection bias, said Dr. Bora Gurel of Johns Hopkins University, Baltimore, and his associates.

The nested case-control study included 191 patients with biopsy-proven prostate cancer and 209 cancer-free patients from the placebo arm of the Prostate Cancer Prevention Trial. To measure the presence and extent of inflammation, a pathologist who was blinded to case-control status examined stained tissue sections from benign areas of prostate biopsy cores. The presence of any inflammatory cells, both acute inflammatory cells and chronic inflammatory cells (cells with an appearance consistent with that of lymphocytes and macrophages) in the benign tissue for each biopsy core on each slide, were noted.

Signs of inflammation were found in at least one biopsy core in 78.2% of controls, 86.2% of cases overall, and 88.4% of high-grade cases. Most of the signs of inflammation in both controls and cases reflected chronic inflammation.

Men who had at least one biopsy core with inflammation had greater odds of a prostate cancer diagnosis (odds ratio, 1.78; 95% confidence interval, 1.04–3.06) than men who had zero cores with inflammation, and even greater odds of a high-grade diagnosis (OR, 2.24; 95% CI, 1.06-4.71), the researchers reported (Cancer Epidemiol. Biomarkers Prev. 2014 April 18 [doi: 10.1158/1055-9965.EPI-13-1126]).

But it was unclear if inflammation preceded cancer onset, because the biopsy cores were obtained to evaluate patients for prostate cancer, the investigators said.

The finding that inflammation, primarily chronic, in benign prostate tissue is associated with an increased odds of prostate cancer, and high-grade prostate cancer in particular, will inform the etiology of this disease, the investigators concluded.

"Identifying those men at highest risk of developing aggressive disease is the first step in being able to prevent lethal prostate cancer," they said. "Rather than targeting interventions to all healthy men, which may result in unintended harms, if causal, the findings from our work may allow preventive interventions to be targeted to those men who would benefit the most," they wrote.

The National Cancer Institute funded the study. The authors disclosed no relevant financial conflicts of interest.

Men whose benign prostate biopsy cores showed signs of chronic inflammation had more than twice the odds of high-grade prostate cancer, investigators reported online April 18 in Cancer Epidemiology, Biomarkers & Prevention.

The association existed even when prostate-specific antigen was low (less than 2 ng/mL at biopsy), suggesting that the results were not due to detection bias, said Dr. Bora Gurel of Johns Hopkins University, Baltimore, and his associates.

The nested case-control study included 191 patients with biopsy-proven prostate cancer and 209 cancer-free patients from the placebo arm of the Prostate Cancer Prevention Trial. To measure the presence and extent of inflammation, a pathologist who was blinded to case-control status examined stained tissue sections from benign areas of prostate biopsy cores. The presence of any inflammatory cells, both acute inflammatory cells and chronic inflammatory cells (cells with an appearance consistent with that of lymphocytes and macrophages) in the benign tissue for each biopsy core on each slide, were noted.

Signs of inflammation were found in at least one biopsy core in 78.2% of controls, 86.2% of cases overall, and 88.4% of high-grade cases. Most of the signs of inflammation in both controls and cases reflected chronic inflammation.

Men who had at least one biopsy core with inflammation had greater odds of a prostate cancer diagnosis (odds ratio, 1.78; 95% confidence interval, 1.04–3.06) than men who had zero cores with inflammation, and even greater odds of a high-grade diagnosis (OR, 2.24; 95% CI, 1.06-4.71), the researchers reported (Cancer Epidemiol. Biomarkers Prev. 2014 April 18 [doi: 10.1158/1055-9965.EPI-13-1126]).

But it was unclear if inflammation preceded cancer onset, because the biopsy cores were obtained to evaluate patients for prostate cancer, the investigators said.

The finding that inflammation, primarily chronic, in benign prostate tissue is associated with an increased odds of prostate cancer, and high-grade prostate cancer in particular, will inform the etiology of this disease, the investigators concluded.

"Identifying those men at highest risk of developing aggressive disease is the first step in being able to prevent lethal prostate cancer," they said. "Rather than targeting interventions to all healthy men, which may result in unintended harms, if causal, the findings from our work may allow preventive interventions to be targeted to those men who would benefit the most," they wrote.

The National Cancer Institute funded the study. The authors disclosed no relevant financial conflicts of interest.

All febrile infants under 1 month old should receive a urine culture because of the prevalence of urinary tract infections and the inadequacy of other clinical parameters in identifying urinary tract infection risk, according to results of a recent study.

Approximately one in six infants aged 30 days or younger experienced urinary tract infections (UTIs), and males were more than twice as likely as females to have one, reported Dr. William Bonadio and Dr. Gary Maida of Maimonides Medical Center in New York.

Infants with a UTI should receive renal ultrasound imaging because nearly half of those with UTIs had radiographic anatomic abnormalities, the authors reported (Pediatr. Infect. Dis. J. 2014;33:342-4).

Of 670 febrile infants evaluated for sepsis in the emergency department at Maimonides Medical Center between 2004 and 2013, a total of 15.4% of the 651 receiving a urine culture had a UTI. Of these, 73% were male, and 47% had anatomic abnormalities appearing on renal ultrasound imaging.

The patients with abnormalities included 19 with pelviectasis and 26 with hydronephrosis. In the 21 patients with hydronephrosis who received a voiding cystourethrogram, 5 had vesicoureteral reflux. None of the infants had bacterial meningitis, and four had urosepsis.

Meanwhile the sensitivity of clinical symptoms, including fever height, CBC total white blood cell count, and urine dipstick test, was insufficient to determine risk of UTI in infants. Among those with UTIs, only 40% had a CBC total white blood cell count of at least 15,000/mm³, and 39% had a fever of 102° F or greater; 79% tested positive for leukocyte esterase or nitrite with a urine dipstick test.

"Reliance on urine dipstick test results to determine whether to perform a urine culture would have resulted in missed diagnosis of 21% of UTI cases in our cohort," the authors wrote. "Similarly, microscopic urinalysis was relatively insensitive at identifying those with underlying UTI."

Escherichia coli was the most common uropathogen, identified in 71% of the patients with UTI, followed by Enterococcus (10%), and Klebsiella species (10%).

The researchers did not report external funding. The authors reported no disclosures.

All febrile infants under 1 month old should receive a urine culture because of the prevalence of urinary tract infections and the inadequacy of other clinical parameters in identifying urinary tract infection risk, according to results of a recent study.

Approximately one in six infants aged 30 days or younger experienced urinary tract infections (UTIs), and males were more than twice as likely as females to have one, reported Dr. William Bonadio and Dr. Gary Maida of Maimonides Medical Center in New York.

Infants with a UTI should receive renal ultrasound imaging because nearly half of those with UTIs had radiographic anatomic abnormalities, the authors reported (Pediatr. Infect. Dis. J. 2014;33:342-4).

Of 670 febrile infants evaluated for sepsis in the emergency department at Maimonides Medical Center between 2004 and 2013, a total of 15.4% of the 651 receiving a urine culture had a UTI. Of these, 73% were male, and 47% had anatomic abnormalities appearing on renal ultrasound imaging.

The patients with abnormalities included 19 with pelviectasis and 26 with hydronephrosis. In the 21 patients with hydronephrosis who received a voiding cystourethrogram, 5 had vesicoureteral reflux. None of the infants had bacterial meningitis, and four had urosepsis.

Meanwhile the sensitivity of clinical symptoms, including fever height, CBC total white blood cell count, and urine dipstick test, was insufficient to determine risk of UTI in infants. Among those with UTIs, only 40% had a CBC total white blood cell count of at least 15,000/mm³, and 39% had a fever of 102° F or greater; 79% tested positive for leukocyte esterase or nitrite with a urine dipstick test.

"Reliance on urine dipstick test results to determine whether to perform a urine culture would have resulted in missed diagnosis of 21% of UTI cases in our cohort," the authors wrote. "Similarly, microscopic urinalysis was relatively insensitive at identifying those with underlying UTI."

Escherichia coli was the most common uropathogen, identified in 71% of the patients with UTI, followed by Enterococcus (10%), and Klebsiella species (10%).

The researchers did not report external funding. The authors reported no disclosures.

All febrile infants under 1 month old should receive a urine culture because of the prevalence of urinary tract infections and the inadequacy of other clinical parameters in identifying urinary tract infection risk, according to results of a recent study.

Approximately one in six infants aged 30 days or younger experienced urinary tract infections (UTIs), and males were more than twice as likely as females to have one, reported Dr. William Bonadio and Dr. Gary Maida of Maimonides Medical Center in New York.

Infants with a UTI should receive renal ultrasound imaging because nearly half of those with UTIs had radiographic anatomic abnormalities, the authors reported (Pediatr. Infect. Dis. J. 2014;33:342-4).

Of 670 febrile infants evaluated for sepsis in the emergency department at Maimonides Medical Center between 2004 and 2013, a total of 15.4% of the 651 receiving a urine culture had a UTI. Of these, 73% were male, and 47% had anatomic abnormalities appearing on renal ultrasound imaging.

The patients with abnormalities included 19 with pelviectasis and 26 with hydronephrosis. In the 21 patients with hydronephrosis who received a voiding cystourethrogram, 5 had vesicoureteral reflux. None of the infants had bacterial meningitis, and four had urosepsis.

Meanwhile the sensitivity of clinical symptoms, including fever height, CBC total white blood cell count, and urine dipstick test, was insufficient to determine risk of UTI in infants. Among those with UTIs, only 40% had a CBC total white blood cell count of at least 15,000/mm³, and 39% had a fever of 102° F or greater; 79% tested positive for leukocyte esterase or nitrite with a urine dipstick test.

"Reliance on urine dipstick test results to determine whether to perform a urine culture would have resulted in missed diagnosis of 21% of UTI cases in our cohort," the authors wrote. "Similarly, microscopic urinalysis was relatively insensitive at identifying those with underlying UTI."

Escherichia coli was the most common uropathogen, identified in 71% of the patients with UTI, followed by Enterococcus (10%), and Klebsiella species (10%).

The researchers did not report external funding. The authors reported no disclosures.

Neither acute bouts of moderate walking nor regular moderate walking are unsafe in patients who have predialysis chronic kidney disease, and both types of exercise may actually reduce systemic inflammation and improve immune function in these patients, according to a report published in the Journal of the American Society of Nephrology.

CKD is associated with "a complex state of immune dysfunction in which signs of immune depression and immune activation paradoxically coexist." Moderate exercise may therefore enhance certain aspects of immune function while simultaneously exerting detrimental effects on other aspects, said Dr. João Viana of the school of sport, exercise, and health sciences, Loughborough (England) University, and his associates.

©Image Source Pink/thinkstockphotos.com

The investigators studied blood biomarkers of immune function and inflammation in 15 adults with predialysis CKD who participated in a single bout of "somewhat hard" walking on a motorized treadmill for 30 minutes. This induced "a systemic anti-inflammatory environment," as evidenced by a marked increase in plasma IL-10 levels. It also improved neutrophil responsiveness to an in vitro bacterial challenge during the hour following the exercise. It had no effect on T-lymphocyte or monocyte activation, the researchers said (J. Am. Soc. Nephrol. 2014; April 3; doi:10.1681/ASN.2013070702]).

In a separate analysis, Dr. Viana and his colleagues assessed the same blood biomarkers in 24 participants in a previous study, who had been assigned to either 6 months of regular home-based walking (13 predialysis CKD patients) or to their usual sedentary activity level (11 control subjects). The "exercisers" walked at a "somewhat hard" rate for 30 minutes per day, 5 times per week.

This regular walking also exerted systemic anti-inflammatory effects, as evidenced by a reduction in the IL-6 to IL-10 ratio and downregulation of T-lymphocyte and monocyte activation. It had no effect on circulating numbers of immune cells or on neutrophil degranulation response. Neither acute nor regular walking affected body weight, renal function, proteinuria, or blood pressure.

These findings suggest that walking "is safe from an immune and inflammatory perspective, and exerts anti-inflammatory effects at both systemic and cellular levels" in this patient population. Regular walking "has the potential to be an effective anti-inflammatory therapy in predialysis CKD patients and may in this way reduce the high risk of cardiovascular disease in these very vulnerable patients," the investigators noted.

The authors reported no financial disclosures.

Neither acute bouts of moderate walking nor regular moderate walking are unsafe in patients who have predialysis chronic kidney disease, and both types of exercise may actually reduce systemic inflammation and improve immune function in these patients, according to a report published in the Journal of the American Society of Nephrology.

CKD is associated with "a complex state of immune dysfunction in which signs of immune depression and immune activation paradoxically coexist." Moderate exercise may therefore enhance certain aspects of immune function while simultaneously exerting detrimental effects on other aspects, said Dr. João Viana of the school of sport, exercise, and health sciences, Loughborough (England) University, and his associates.

©Image Source Pink/thinkstockphotos.com

The investigators studied blood biomarkers of immune function and inflammation in 15 adults with predialysis CKD who participated in a single bout of "somewhat hard" walking on a motorized treadmill for 30 minutes. This induced "a systemic anti-inflammatory environment," as evidenced by a marked increase in plasma IL-10 levels. It also improved neutrophil responsiveness to an in vitro bacterial challenge during the hour following the exercise. It had no effect on T-lymphocyte or monocyte activation, the researchers said (J. Am. Soc. Nephrol. 2014; April 3; doi:10.1681/ASN.2013070702]).

In a separate analysis, Dr. Viana and his colleagues assessed the same blood biomarkers in 24 participants in a previous study, who had been assigned to either 6 months of regular home-based walking (13 predialysis CKD patients) or to their usual sedentary activity level (11 control subjects). The "exercisers" walked at a "somewhat hard" rate for 30 minutes per day, 5 times per week.

This regular walking also exerted systemic anti-inflammatory effects, as evidenced by a reduction in the IL-6 to IL-10 ratio and downregulation of T-lymphocyte and monocyte activation. It had no effect on circulating numbers of immune cells or on neutrophil degranulation response. Neither acute nor regular walking affected body weight, renal function, proteinuria, or blood pressure.

These findings suggest that walking "is safe from an immune and inflammatory perspective, and exerts anti-inflammatory effects at both systemic and cellular levels" in this patient population. Regular walking "has the potential to be an effective anti-inflammatory therapy in predialysis CKD patients and may in this way reduce the high risk of cardiovascular disease in these very vulnerable patients," the investigators noted.

The authors reported no financial disclosures.

Neither acute bouts of moderate walking nor regular moderate walking are unsafe in patients who have predialysis chronic kidney disease, and both types of exercise may actually reduce systemic inflammation and improve immune function in these patients, according to a report published in the Journal of the American Society of Nephrology.

CKD is associated with "a complex state of immune dysfunction in which signs of immune depression and immune activation paradoxically coexist." Moderate exercise may therefore enhance certain aspects of immune function while simultaneously exerting detrimental effects on other aspects, said Dr. João Viana of the school of sport, exercise, and health sciences, Loughborough (England) University, and his associates.

©Image Source Pink/thinkstockphotos.com

The investigators studied blood biomarkers of immune function and inflammation in 15 adults with predialysis CKD who participated in a single bout of "somewhat hard" walking on a motorized treadmill for 30 minutes. This induced "a systemic anti-inflammatory environment," as evidenced by a marked increase in plasma IL-10 levels. It also improved neutrophil responsiveness to an in vitro bacterial challenge during the hour following the exercise. It had no effect on T-lymphocyte or monocyte activation, the researchers said (J. Am. Soc. Nephrol. 2014; April 3; doi:10.1681/ASN.2013070702]).

In a separate analysis, Dr. Viana and his colleagues assessed the same blood biomarkers in 24 participants in a previous study, who had been assigned to either 6 months of regular home-based walking (13 predialysis CKD patients) or to their usual sedentary activity level (11 control subjects). The "exercisers" walked at a "somewhat hard" rate for 30 minutes per day, 5 times per week.

This regular walking also exerted systemic anti-inflammatory effects, as evidenced by a reduction in the IL-6 to IL-10 ratio and downregulation of T-lymphocyte and monocyte activation. It had no effect on circulating numbers of immune cells or on neutrophil degranulation response. Neither acute nor regular walking affected body weight, renal function, proteinuria, or blood pressure.

These findings suggest that walking "is safe from an immune and inflammatory perspective, and exerts anti-inflammatory effects at both systemic and cellular levels" in this patient population. Regular walking "has the potential to be an effective anti-inflammatory therapy in predialysis CKD patients and may in this way reduce the high risk of cardiovascular disease in these very vulnerable patients," the investigators noted.

The authors reported no financial disclosures.

WASHINGTON – Far from being doomed after the failure SYMPLICITY HTN-3, renal denervation for refractory hypertension will continue to be explored. But it can’t go very far without finding a way to measure its effectiveness.

In Part 2 of our interview, Dr. Prakash Deedwania and Dr. George Bakris explore the options, and don’t miss the chance to talk about the controversial new hypertension guidelines.

[email protected]

On Twitter @mitchelzoler

WASHINGTON – Far from being doomed after the failure SYMPLICITY HTN-3, renal denervation for refractory hypertension will continue to be explored. But it can’t go very far without finding a way to measure its effectiveness.

In Part 2 of our interview, Dr. Prakash Deedwania and Dr. George Bakris explore the options, and don’t miss the chance to talk about the controversial new hypertension guidelines.

[email protected]

On Twitter @mitchelzoler

WASHINGTON – Far from being doomed after the failure SYMPLICITY HTN-3, renal denervation for refractory hypertension will continue to be explored. But it can’t go very far without finding a way to measure its effectiveness.

In Part 2 of our interview, Dr. Prakash Deedwania and Dr. George Bakris explore the options, and don’t miss the chance to talk about the controversial new hypertension guidelines.

[email protected]

On Twitter @mitchelzoler

Acute kidney injury is a serious adverse effect of cardiac surgery, and contrast-induced nephropathy due to coronary angiography has been suggested as a potentially important component. However, the results of a retrospective study of more than 2,500 patients showed that acute kidney injury is significantly higher only in those patients who have combined cardiac surgery within 24 hours of catheterization.

The study by Dr. Giovanni Mariscalco of the Varese (Italy) University Hospital, and his colleagues assessed all consecutive patients undergoing cardiac surgery at the hospital between Jan. 1, 2005, and Dec. 31, 2011. The operations performed were isolated coronary artery bypass grafting (CABG), valve surgery with or without concomitant CABG, and proximal aortic procedures. After exclusion of patients who did not undergo cardiopulmonary bypass, a known major cause of acute kidney injury (AKI), and those who died during the procedure, a total of 2,504 patients remained. These patients had a mean age of 68.4 years and consisted mostly of men (67.3%), according to the report in the April issue of the International Journal of Cardiology.

Courtesy Wikimedia Commons/ Pantaleo et al. BMC Cancer 2012.12:231/Creative Commons License

The primary endpoint of the study was the effect of timing between cardiac catheterization and surgery on the development of AKI. Postoperative AKI was defined by the consensus RIFLE criteria (risk, injury, failure, loss of function, and end-stage renal disease), using the maximal change in serum creatinine and the estimated glomerular filtration rate during the first 7 days after surgery, compared with baseline values collected the day before surgery or immediately before surgery when cardiac catheterization was performed on the same day as the operation.

The researchers defined AKI as a 50% increase in the postoperative serum creatinine over baseline. Propensity analysis was used to match patients, who were then assessed both pre- and postmatch.

The overall incidence of AKI after surgery was 9.2% (230/2,504 patients). A breakdown by procedure showed that AKI occurred in 7.7% of isolated CABG patients, 12.2% of isolated valve patients, 9.5% of combined-procedure patients, and 9.5% of the proximal aorta surgery patients (Int. J. Cardiol. 2014;173:46-54).

As has been seen in previous studies, AKI was associated with patient-specific pre- and perioperative variables, including increased patient age, added comorbidities, longer cardiopulmonary bypass (CPB) times, higher rates of combined procedures, and the use of intra-aortic balloon pumps.

Unadjusted analysis of the total cohort showed AKI was significantly associated with contrast exposure within 1 day of surgery. However, in multivariable analysis, the time interval between catheterization and surgery as both a categorical and continuous variable was not an independent predictor of postoperative AKI for the total cohort. In subgroup analysis, only the combined valve and CABG group of patients showed an independent association of contrast exposure within 1 day before surgery and AKI in both the prematched (odds ratio, 2.69; P = .004) and the postmatched (OR, 3.68; P = .014) groups.

"Avoiding surgery within 1 day after contrast exposure should be recommended for patients undergoing valve surgery with concomitant CABG only. For other types of cardiac operations, delaying cardiac surgery after contrast exposure seems not to be justified," the researchers concluded.

Study limitations cited include its retrospective and single-institution nature and the statistical effect of different numbers of observations among the surgery groups. Patients affected with AKI also had higher rates of other postoperative complications, and AKI in some cases may have been the result of these rather than an independent event.

he study was supported by the Fondazione Cesare Bartorelli. The authors reported having no financial disclosures.

[email protected]

Acute kidney injury is a serious adverse effect of cardiac surgery, and contrast-induced nephropathy due to coronary angiography has been suggested as a potentially important component. However, the results of a retrospective study of more than 2,500 patients showed that acute kidney injury is significantly higher only in those patients who have combined cardiac surgery within 24 hours of catheterization.

The study by Dr. Giovanni Mariscalco of the Varese (Italy) University Hospital, and his colleagues assessed all consecutive patients undergoing cardiac surgery at the hospital between Jan. 1, 2005, and Dec. 31, 2011. The operations performed were isolated coronary artery bypass grafting (CABG), valve surgery with or without concomitant CABG, and proximal aortic procedures. After exclusion of patients who did not undergo cardiopulmonary bypass, a known major cause of acute kidney injury (AKI), and those who died during the procedure, a total of 2,504 patients remained. These patients had a mean age of 68.4 years and consisted mostly of men (67.3%), according to the report in the April issue of the International Journal of Cardiology.

Courtesy Wikimedia Commons/ Pantaleo et al. BMC Cancer 2012.12:231/Creative Commons License

The primary endpoint of the study was the effect of timing between cardiac catheterization and surgery on the development of AKI. Postoperative AKI was defined by the consensus RIFLE criteria (risk, injury, failure, loss of function, and end-stage renal disease), using the maximal change in serum creatinine and the estimated glomerular filtration rate during the first 7 days after surgery, compared with baseline values collected the day before surgery or immediately before surgery when cardiac catheterization was performed on the same day as the operation.

The researchers defined AKI as a 50% increase in the postoperative serum creatinine over baseline. Propensity analysis was used to match patients, who were then assessed both pre- and postmatch.

The overall incidence of AKI after surgery was 9.2% (230/2,504 patients). A breakdown by procedure showed that AKI occurred in 7.7% of isolated CABG patients, 12.2% of isolated valve patients, 9.5% of combined-procedure patients, and 9.5% of the proximal aorta surgery patients (Int. J. Cardiol. 2014;173:46-54).

As has been seen in previous studies, AKI was associated with patient-specific pre- and perioperative variables, including increased patient age, added comorbidities, longer cardiopulmonary bypass (CPB) times, higher rates of combined procedures, and the use of intra-aortic balloon pumps.

Unadjusted analysis of the total cohort showed AKI was significantly associated with contrast exposure within 1 day of surgery. However, in multivariable analysis, the time interval between catheterization and surgery as both a categorical and continuous variable was not an independent predictor of postoperative AKI for the total cohort. In subgroup analysis, only the combined valve and CABG group of patients showed an independent association of contrast exposure within 1 day before surgery and AKI in both the prematched (odds ratio, 2.69; P = .004) and the postmatched (OR, 3.68; P = .014) groups.

"Avoiding surgery within 1 day after contrast exposure should be recommended for patients undergoing valve surgery with concomitant CABG only. For other types of cardiac operations, delaying cardiac surgery after contrast exposure seems not to be justified," the researchers concluded.

Study limitations cited include its retrospective and single-institution nature and the statistical effect of different numbers of observations among the surgery groups. Patients affected with AKI also had higher rates of other postoperative complications, and AKI in some cases may have been the result of these rather than an independent event.

he study was supported by the Fondazione Cesare Bartorelli. The authors reported having no financial disclosures.

[email protected]

Acute kidney injury is a serious adverse effect of cardiac surgery, and contrast-induced nephropathy due to coronary angiography has been suggested as a potentially important component. However, the results of a retrospective study of more than 2,500 patients showed that acute kidney injury is significantly higher only in those patients who have combined cardiac surgery within 24 hours of catheterization.

The study by Dr. Giovanni Mariscalco of the Varese (Italy) University Hospital, and his colleagues assessed all consecutive patients undergoing cardiac surgery at the hospital between Jan. 1, 2005, and Dec. 31, 2011. The operations performed were isolated coronary artery bypass grafting (CABG), valve surgery with or without concomitant CABG, and proximal aortic procedures. After exclusion of patients who did not undergo cardiopulmonary bypass, a known major cause of acute kidney injury (AKI), and those who died during the procedure, a total of 2,504 patients remained. These patients had a mean age of 68.4 years and consisted mostly of men (67.3%), according to the report in the April issue of the International Journal of Cardiology.

Courtesy Wikimedia Commons/ Pantaleo et al. BMC Cancer 2012.12:231/Creative Commons License

The primary endpoint of the study was the effect of timing between cardiac catheterization and surgery on the development of AKI. Postoperative AKI was defined by the consensus RIFLE criteria (risk, injury, failure, loss of function, and end-stage renal disease), using the maximal change in serum creatinine and the estimated glomerular filtration rate during the first 7 days after surgery, compared with baseline values collected the day before surgery or immediately before surgery when cardiac catheterization was performed on the same day as the operation.

The researchers defined AKI as a 50% increase in the postoperative serum creatinine over baseline. Propensity analysis was used to match patients, who were then assessed both pre- and postmatch.

The overall incidence of AKI after surgery was 9.2% (230/2,504 patients). A breakdown by procedure showed that AKI occurred in 7.7% of isolated CABG patients, 12.2% of isolated valve patients, 9.5% of combined-procedure patients, and 9.5% of the proximal aorta surgery patients (Int. J. Cardiol. 2014;173:46-54).

As has been seen in previous studies, AKI was associated with patient-specific pre- and perioperative variables, including increased patient age, added comorbidities, longer cardiopulmonary bypass (CPB) times, higher rates of combined procedures, and the use of intra-aortic balloon pumps.

Unadjusted analysis of the total cohort showed AKI was significantly associated with contrast exposure within 1 day of surgery. However, in multivariable analysis, the time interval between catheterization and surgery as both a categorical and continuous variable was not an independent predictor of postoperative AKI for the total cohort. In subgroup analysis, only the combined valve and CABG group of patients showed an independent association of contrast exposure within 1 day before surgery and AKI in both the prematched (odds ratio, 2.69; P = .004) and the postmatched (OR, 3.68; P = .014) groups.

"Avoiding surgery within 1 day after contrast exposure should be recommended for patients undergoing valve surgery with concomitant CABG only. For other types of cardiac operations, delaying cardiac surgery after contrast exposure seems not to be justified," the researchers concluded.

Study limitations cited include its retrospective and single-institution nature and the statistical effect of different numbers of observations among the surgery groups. Patients affected with AKI also had higher rates of other postoperative complications, and AKI in some cases may have been the result of these rather than an independent event.

he study was supported by the Fondazione Cesare Bartorelli. The authors reported having no financial disclosures.

[email protected]

WASHINGTON – Renal denervation’s not so simple after all.

Highly anticipated data from the large, sham-controlled renal-artery catheter denervation trial, SYMPLICITY HTN-3, gave its investigators reason to believe that inconsistent and inadequate delivery of nerve-ablating radiofrequency energy by inexperienced operators left too many patients undertreated, producing a neutral outcome for the primary endpoint, the study’s top-line result first reported in a company press release in January.

In the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension) trial, the average systolic blood pressure reduction among the 364 patients randomized to renal denervation was 14 mm Hg, compared with an average 12 mm Hg reduction in 174 control patients who underwent a renal-artery angiogram masked to resemble a denervation procedure, a difference that was not statistically significant, falling substantially short of the prespecified 5 mm Hg between group difference necessary to fulfill superiority, Dr. Deepak L. Bhatt said at the annual meeting of the American College of Cardiology.

Mitchel L. Zoler/Frontline Medical News

Although several factors likely led to the neutral outcome, including an unexpectedly robust blood pressure drop in the control arm, another major factor, many suspect, was inadequate delivery of the denervation treatment.

"It might be that the way we used the catheter wasn’t ideal," said Dr. Bhatt, coprincipal investigator of the study, professor of medicine at Harvard Medical School and executive director of interventional cardiology at Brigham and Women’s Hospital, both in Boston.

Concurrent with Dr. Bhatt’s report at the meeting a published version appeared online (N. Engl. J. Med. 2014 March 29 [doi:10.1056/NEJMoa1402670]).

"There is the concept that renal denervation is easy. As a catheter procedure it is easy, but to achieve denervation is far from easy," said Dr. Murray D. Esler, a professor of medicine at Monash University and senior director of the Baker IDI Heart and Diabetes Institute, both in Melbourne, and a pioneer of renal denervation who was involved in prior SYMPLICITY studies of the same renal-denervation device but was not a coinvestigator for the new trial.

"The SYMPLICITY 3 study made a mistake thinking it could get away with not giving the proceduralists any hands-on experience" before the trial. "There was none. The operators hadn’t done it before, and the trial’s designers would not have done that unless they thought that denervation was easy. Well, it’s not easy. There is a learning curve, and I think that’s the main explanation of what went wrong. "

Mitchel L. Zoler/Frontline Medical News

Exacerbating the operators’ inexperience with denervation (they were all experienced interventional cardiologists) was a second flaw in the trial’s design: No method was used to monitor the efficacy of each denervation procedure, an easy decision because there is still no proven way to measure denervation efficacy during the procedure. Dr. Esler said he believes that he has a solution, one that involves testing for interrupted activity of the parallel, afferent nerves of the renal arteries using adenosine as a surrogate measure for denervation of the target efferent nerves. But while he is optimistic the adenosine approach will work, it is still at least several months from use in a trial.

In the first clinical study of renal denervation, a series of 50 patients treated at five centers in Australia and Europe reported just 5 years ago (Lancet 2009;373:1275-81), Dr. Esler, a lead investigator for that study, and his associates carefully tested the efficacy of denervation in 10 patients by measuring the direct effect of successful denervation, reduction of renal norepinephrine spillover. They reported that, in those 10 patients, renal denervation cut norepinephrine spillover by an average 47%, which correlated with an average reduction in systolic blood pressure of 22 mm Hg after 6 months.

But this effect from denervation was "far from uniform and ranged from zero to 85%," depending on who was doing the denervation. "It’s obviously operator dependent." Dr. Esler said in an interview. This observation of enormous variability in the physiologic impact of denervation "took on a new context with the failed trial. The denervation done by novices explains to some extent the spread [in results] and makes me think the same thing happened in SYMPLICITY 3."

Nick Piegari/Frontline Medical News

"If you don’t do enough high-frequency burns or if the catheter doesn’t reach enough nerves" because of misplacement within the renal artery, the denervation won’t be very successful, noted Dr. George Bakris, professor of medicine and director of the comprehensive hypertension center at the University of Chicago and coprincipal investigator of SYMPLICITY HTN-3 along with Dr. Bhatt. "It certainly calls into question whether they denervated effectively. One could argue that if denervation were done appropriately" it would add to drug treatment, Dr. Bakris said in an interview. "This issue has come up about the quality of the denervation; the good news is that it can be done correctly," but that will require "a good understanding of what you are doing to the renal nerves and how much energy you need." SYMPLICITY HTN-3 "was a good but expensive learning experience," Dr. Bakris said.

The investigators "were performing a procedure, but they didn’t have the evidence that the procedure was accomplishing what it meant to accomplish," commented Dr. Anthony DeMaria, professor of medicine, the Judith and Jack White chair of cardiology, and director of the cardiovascular center at the University of California, San Diego, who was not involved in the trial. "Most of us feel there are tantalizing data to suggest that denervation can have a benefit, but they need to go back to the physiology to be sure they are denervating effectively."

Mitchel L. Zoler/Frontline Medical News

Though Dr. Bakris and Dr. Esler cautioned that the study’s primary outcome was neutral, they see reason to hope that renal denervation will still prove to have an important and useful clinical effect.

"This report is the tip of the iceberg," Dr. Bakris noted. "When you look at the effect of denervation on blood pressure variability, heart rate variability, and total control over 24 hours using ambulatory blood pressure monitoring, you see a different picture," results that will be reported later this year, he said.

And Dr. Esler said that his experience using renal denervation on about 300 patients with treatment-resistant hypertension has convinced him that denervation can produce real benefits when done properly.

"I’m not changing my practice" using renal denervation on refractory patients, he said. "I accumulated a lot of patients with severe, resistant hypertension, patients whom I couldn’t control with seven or eight different drug classes. But when renal denervation came along, it was like chalk and cheese. Suddenly, I had a therapy that worked. My clinical experience in patients who didn’t budge with medications totally convinces me" that renal denervation works.

SYMPLICITY HTN-3 was sponsored by Medtronic, the company that markets the device tested in the study. Dr. Bhatt said that he has received research grants from Medtronic and five other companies. Dr. Esler said that he has received consulting fees, honoraria, and research grants from Medtronic. Dr. Bakris said that he has received personal fees from Medtronic and five other companies. Dr. DeMaria said that he has received research grants from Angioblast Systems, Cardiovascular Biotherapeutics, General Electric Medical, Gilead, and Lantheus.

[email protected]

On Twitter @mitchelzoler

WASHINGTON – Renal denervation’s not so simple after all.

Highly anticipated data from the large, sham-controlled renal-artery catheter denervation trial, SYMPLICITY HTN-3, gave its investigators reason to believe that inconsistent and inadequate delivery of nerve-ablating radiofrequency energy by inexperienced operators left too many patients undertreated, producing a neutral outcome for the primary endpoint, the study’s top-line result first reported in a company press release in January.

In the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension) trial, the average systolic blood pressure reduction among the 364 patients randomized to renal denervation was 14 mm Hg, compared with an average 12 mm Hg reduction in 174 control patients who underwent a renal-artery angiogram masked to resemble a denervation procedure, a difference that was not statistically significant, falling substantially short of the prespecified 5 mm Hg between group difference necessary to fulfill superiority, Dr. Deepak L. Bhatt said at the annual meeting of the American College of Cardiology.

Mitchel L. Zoler/Frontline Medical News

Although several factors likely led to the neutral outcome, including an unexpectedly robust blood pressure drop in the control arm, another major factor, many suspect, was inadequate delivery of the denervation treatment.

"It might be that the way we used the catheter wasn’t ideal," said Dr. Bhatt, coprincipal investigator of the study, professor of medicine at Harvard Medical School and executive director of interventional cardiology at Brigham and Women’s Hospital, both in Boston.

Concurrent with Dr. Bhatt’s report at the meeting a published version appeared online (N. Engl. J. Med. 2014 March 29 [doi:10.1056/NEJMoa1402670]).

"There is the concept that renal denervation is easy. As a catheter procedure it is easy, but to achieve denervation is far from easy," said Dr. Murray D. Esler, a professor of medicine at Monash University and senior director of the Baker IDI Heart and Diabetes Institute, both in Melbourne, and a pioneer of renal denervation who was involved in prior SYMPLICITY studies of the same renal-denervation device but was not a coinvestigator for the new trial.

"The SYMPLICITY 3 study made a mistake thinking it could get away with not giving the proceduralists any hands-on experience" before the trial. "There was none. The operators hadn’t done it before, and the trial’s designers would not have done that unless they thought that denervation was easy. Well, it’s not easy. There is a learning curve, and I think that’s the main explanation of what went wrong. "

Mitchel L. Zoler/Frontline Medical News

Exacerbating the operators’ inexperience with denervation (they were all experienced interventional cardiologists) was a second flaw in the trial’s design: No method was used to monitor the efficacy of each denervation procedure, an easy decision because there is still no proven way to measure denervation efficacy during the procedure. Dr. Esler said he believes that he has a solution, one that involves testing for interrupted activity of the parallel, afferent nerves of the renal arteries using adenosine as a surrogate measure for denervation of the target efferent nerves. But while he is optimistic the adenosine approach will work, it is still at least several months from use in a trial.

In the first clinical study of renal denervation, a series of 50 patients treated at five centers in Australia and Europe reported just 5 years ago (Lancet 2009;373:1275-81), Dr. Esler, a lead investigator for that study, and his associates carefully tested the efficacy of denervation in 10 patients by measuring the direct effect of successful denervation, reduction of renal norepinephrine spillover. They reported that, in those 10 patients, renal denervation cut norepinephrine spillover by an average 47%, which correlated with an average reduction in systolic blood pressure of 22 mm Hg after 6 months.

But this effect from denervation was "far from uniform and ranged from zero to 85%," depending on who was doing the denervation. "It’s obviously operator dependent." Dr. Esler said in an interview. This observation of enormous variability in the physiologic impact of denervation "took on a new context with the failed trial. The denervation done by novices explains to some extent the spread [in results] and makes me think the same thing happened in SYMPLICITY 3."

Nick Piegari/Frontline Medical News

"If you don’t do enough high-frequency burns or if the catheter doesn’t reach enough nerves" because of misplacement within the renal artery, the denervation won’t be very successful, noted Dr. George Bakris, professor of medicine and director of the comprehensive hypertension center at the University of Chicago and coprincipal investigator of SYMPLICITY HTN-3 along with Dr. Bhatt. "It certainly calls into question whether they denervated effectively. One could argue that if denervation were done appropriately" it would add to drug treatment, Dr. Bakris said in an interview. "This issue has come up about the quality of the denervation; the good news is that it can be done correctly," but that will require "a good understanding of what you are doing to the renal nerves and how much energy you need." SYMPLICITY HTN-3 "was a good but expensive learning experience," Dr. Bakris said.

The investigators "were performing a procedure, but they didn’t have the evidence that the procedure was accomplishing what it meant to accomplish," commented Dr. Anthony DeMaria, professor of medicine, the Judith and Jack White chair of cardiology, and director of the cardiovascular center at the University of California, San Diego, who was not involved in the trial. "Most of us feel there are tantalizing data to suggest that denervation can have a benefit, but they need to go back to the physiology to be sure they are denervating effectively."

Mitchel L. Zoler/Frontline Medical News

Though Dr. Bakris and Dr. Esler cautioned that the study’s primary outcome was neutral, they see reason to hope that renal denervation will still prove to have an important and useful clinical effect.

"This report is the tip of the iceberg," Dr. Bakris noted. "When you look at the effect of denervation on blood pressure variability, heart rate variability, and total control over 24 hours using ambulatory blood pressure monitoring, you see a different picture," results that will be reported later this year, he said.

And Dr. Esler said that his experience using renal denervation on about 300 patients with treatment-resistant hypertension has convinced him that denervation can produce real benefits when done properly.

"I’m not changing my practice" using renal denervation on refractory patients, he said. "I accumulated a lot of patients with severe, resistant hypertension, patients whom I couldn’t control with seven or eight different drug classes. But when renal denervation came along, it was like chalk and cheese. Suddenly, I had a therapy that worked. My clinical experience in patients who didn’t budge with medications totally convinces me" that renal denervation works.

SYMPLICITY HTN-3 was sponsored by Medtronic, the company that markets the device tested in the study. Dr. Bhatt said that he has received research grants from Medtronic and five other companies. Dr. Esler said that he has received consulting fees, honoraria, and research grants from Medtronic. Dr. Bakris said that he has received personal fees from Medtronic and five other companies. Dr. DeMaria said that he has received research grants from Angioblast Systems, Cardiovascular Biotherapeutics, General Electric Medical, Gilead, and Lantheus.

[email protected]

On Twitter @mitchelzoler

WASHINGTON – Renal denervation’s not so simple after all.

Highly anticipated data from the large, sham-controlled renal-artery catheter denervation trial, SYMPLICITY HTN-3, gave its investigators reason to believe that inconsistent and inadequate delivery of nerve-ablating radiofrequency energy by inexperienced operators left too many patients undertreated, producing a neutral outcome for the primary endpoint, the study’s top-line result first reported in a company press release in January.

In the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension) trial, the average systolic blood pressure reduction among the 364 patients randomized to renal denervation was 14 mm Hg, compared with an average 12 mm Hg reduction in 174 control patients who underwent a renal-artery angiogram masked to resemble a denervation procedure, a difference that was not statistically significant, falling substantially short of the prespecified 5 mm Hg between group difference necessary to fulfill superiority, Dr. Deepak L. Bhatt said at the annual meeting of the American College of Cardiology.

Mitchel L. Zoler/Frontline Medical News

Although several factors likely led to the neutral outcome, including an unexpectedly robust blood pressure drop in the control arm, another major factor, many suspect, was inadequate delivery of the denervation treatment.

"It might be that the way we used the catheter wasn’t ideal," said Dr. Bhatt, coprincipal investigator of the study, professor of medicine at Harvard Medical School and executive director of interventional cardiology at Brigham and Women’s Hospital, both in Boston.

Concurrent with Dr. Bhatt’s report at the meeting a published version appeared online (N. Engl. J. Med. 2014 March 29 [doi:10.1056/NEJMoa1402670]).

"There is the concept that renal denervation is easy. As a catheter procedure it is easy, but to achieve denervation is far from easy," said Dr. Murray D. Esler, a professor of medicine at Monash University and senior director of the Baker IDI Heart and Diabetes Institute, both in Melbourne, and a pioneer of renal denervation who was involved in prior SYMPLICITY studies of the same renal-denervation device but was not a coinvestigator for the new trial.

"The SYMPLICITY 3 study made a mistake thinking it could get away with not giving the proceduralists any hands-on experience" before the trial. "There was none. The operators hadn’t done it before, and the trial’s designers would not have done that unless they thought that denervation was easy. Well, it’s not easy. There is a learning curve, and I think that’s the main explanation of what went wrong. "

Mitchel L. Zoler/Frontline Medical News

Exacerbating the operators’ inexperience with denervation (they were all experienced interventional cardiologists) was a second flaw in the trial’s design: No method was used to monitor the efficacy of each denervation procedure, an easy decision because there is still no proven way to measure denervation efficacy during the procedure. Dr. Esler said he believes that he has a solution, one that involves testing for interrupted activity of the parallel, afferent nerves of the renal arteries using adenosine as a surrogate measure for denervation of the target efferent nerves. But while he is optimistic the adenosine approach will work, it is still at least several months from use in a trial.

In the first clinical study of renal denervation, a series of 50 patients treated at five centers in Australia and Europe reported just 5 years ago (Lancet 2009;373:1275-81), Dr. Esler, a lead investigator for that study, and his associates carefully tested the efficacy of denervation in 10 patients by measuring the direct effect of successful denervation, reduction of renal norepinephrine spillover. They reported that, in those 10 patients, renal denervation cut norepinephrine spillover by an average 47%, which correlated with an average reduction in systolic blood pressure of 22 mm Hg after 6 months.

But this effect from denervation was "far from uniform and ranged from zero to 85%," depending on who was doing the denervation. "It’s obviously operator dependent." Dr. Esler said in an interview. This observation of enormous variability in the physiologic impact of denervation "took on a new context with the failed trial. The denervation done by novices explains to some extent the spread [in results] and makes me think the same thing happened in SYMPLICITY 3."

Nick Piegari/Frontline Medical News

"If you don’t do enough high-frequency burns or if the catheter doesn’t reach enough nerves" because of misplacement within the renal artery, the denervation won’t be very successful, noted Dr. George Bakris, professor of medicine and director of the comprehensive hypertension center at the University of Chicago and coprincipal investigator of SYMPLICITY HTN-3 along with Dr. Bhatt. "It certainly calls into question whether they denervated effectively. One could argue that if denervation were done appropriately" it would add to drug treatment, Dr. Bakris said in an interview. "This issue has come up about the quality of the denervation; the good news is that it can be done correctly," but that will require "a good understanding of what you are doing to the renal nerves and how much energy you need." SYMPLICITY HTN-3 "was a good but expensive learning experience," Dr. Bakris said.

The investigators "were performing a procedure, but they didn’t have the evidence that the procedure was accomplishing what it meant to accomplish," commented Dr. Anthony DeMaria, professor of medicine, the Judith and Jack White chair of cardiology, and director of the cardiovascular center at the University of California, San Diego, who was not involved in the trial. "Most of us feel there are tantalizing data to suggest that denervation can have a benefit, but they need to go back to the physiology to be sure they are denervating effectively."

Mitchel L. Zoler/Frontline Medical News

Though Dr. Bakris and Dr. Esler cautioned that the study’s primary outcome was neutral, they see reason to hope that renal denervation will still prove to have an important and useful clinical effect.

"This report is the tip of the iceberg," Dr. Bakris noted. "When you look at the effect of denervation on blood pressure variability, heart rate variability, and total control over 24 hours using ambulatory blood pressure monitoring, you see a different picture," results that will be reported later this year, he said.

And Dr. Esler said that his experience using renal denervation on about 300 patients with treatment-resistant hypertension has convinced him that denervation can produce real benefits when done properly.

"I’m not changing my practice" using renal denervation on refractory patients, he said. "I accumulated a lot of patients with severe, resistant hypertension, patients whom I couldn’t control with seven or eight different drug classes. But when renal denervation came along, it was like chalk and cheese. Suddenly, I had a therapy that worked. My clinical experience in patients who didn’t budge with medications totally convinces me" that renal denervation works.

SYMPLICITY HTN-3 was sponsored by Medtronic, the company that markets the device tested in the study. Dr. Bhatt said that he has received research grants from Medtronic and five other companies. Dr. Esler said that he has received consulting fees, honoraria, and research grants from Medtronic. Dr. Bakris said that he has received personal fees from Medtronic and five other companies. Dr. DeMaria said that he has received research grants from Angioblast Systems, Cardiovascular Biotherapeutics, General Electric Medical, Gilead, and Lantheus.

[email protected]

On Twitter @mitchelzoler

WASHINGTON  – What can explain the failure of SYMPLICITY HTN-3? After clinical success in reducing blood pressure by 20-30 mm HG in patients with resistant hypertension, the renal denervation treatment showed no significant reduction in the first randomized trial in which control patients underwent sham operations.

According to two top hypertension experts, trial investigator Dr. George Bakris and Dr. Prakash Deedwania, physiology, behavior, and technology come to mind for starters, as explored in Part 1 of our interview.

[email protected]

WASHINGTON  – What can explain the failure of SYMPLICITY HTN-3? After clinical success in reducing blood pressure by 20-30 mm HG in patients with resistant hypertension, the renal denervation treatment showed no significant reduction in the first randomized trial in which control patients underwent sham operations.

According to two top hypertension experts, trial investigator Dr. George Bakris and Dr. Prakash Deedwania, physiology, behavior, and technology come to mind for starters, as explored in Part 1 of our interview.

[email protected]

WASHINGTON  – What can explain the failure of SYMPLICITY HTN-3? After clinical success in reducing blood pressure by 20-30 mm HG in patients with resistant hypertension, the renal denervation treatment showed no significant reduction in the first randomized trial in which control patients underwent sham operations.

According to two top hypertension experts, trial investigator Dr. George Bakris and Dr. Prakash Deedwania, physiology, behavior, and technology come to mind for starters, as explored in Part 1 of our interview.

[email protected]

SCOTTSDALE, ARIZ. – Optimal management of patients with chronic kidney disease involves knowing what can be modified, understanding that much is uncertain, and having the wisdom to know the difference, suggested an anesthesiologist at a meeting on perioperative medicine sponsored by the University of Miami.

"There is a lot to be done in terms of evaluation of chronic kidney disease and also defining interventions," said Dr. Claus U. Niemann, professor of anesthesia and surgery at the University of California, San Francisco.

Kidney disease is identified either by markers of function such as glomerular filtration rate (GFR), markers of damage such as proteinuria, and markers of volume sense, such as edema, ascites, and urinary sodium excretion.

None of these measures is particularly accurate at measuring disease, however. For example, GFR is not observed directly but estimated from creatinine clearance, which is produced by the body in varying amounts daily and which depends on muscle mass, so that values for a young, muscular man will be higher than those of a small, older woman, Dr. Niemann noted.

In addition, even in people without kidney disease, GFR declines gradually with age, from about 116 mL/min per 1.73 m² for people in their 20s, to about 75 mL/min per 1.73 m² in those aged 70 years and older.

In 2002, the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) developed a five-stage classification for chronic kidney disease (CKD), based on GFR, with CKD defined as either a GFR of less than 60 mL/min per 1.73 m² for more than 3 months or evidence of kidney damage for more than 3 months, based on the presence of abnormalities such as proteinuria. The classification notes that a combination of GFR less than 60 mL/min per 1.73 m² and proteinuria is prognostic.

The classification includes moderately and severely reduced GFR, with respective rates of 30-59 and 15-29 mL/min per 1.73 m², respectively, and end-stage renal disease, with a GFR less than 15 mL/min per 1.73 m² or a need for dialysis,

The most common cause of CKD is diabetic nephropathy or hypertensive nephrosclerosis, which account for 67% of all cases. About 1 in 5 or 1 in 6 Americans has some form of CKD, and the problem can be lifelong, Dr. Niemann said.

Risk stratification

The goal of perioperative management of patients with CKD is to prevent further renal impairment from acute kidney injury, a rapid reduction in kidney function as measured by a significant rise in serum creatinine levels or reduction in urine output within 48 hours of exposure.

Approximately 5%-7% of all hospitalized patients experience some degree of acute kidney injury and changes in serum creatinine of only 0.3 mg/dL have been associated with greater length of stay and increased morbidity and mortality, Dr. Niemann said.

"What is really necessary is that we do perioperative risk stratification. We want to identify the subset of patients who are at risk, we can do tests potentially, and we want to understand what the procedure is, put it in the context of the patient and his renal disease, and then hopefully define a plan and get him to surgery," Dr. Niemann said.

Defining perioperative renal risk involves determining as best as possible the extent of renal insufficiency or CKD, the etiology of the kidney disease (including severity and complications), and the risk of loss of kidney function from the planned or urgent/emergent surgery. The preop clinical team should also know where the patient will be discharged after surgery (home, ICU, floor).

Risk factors for in-hospital acute renal failure include baseline risks, such as age, diabetes, heart or liver failure, and male sex; acute clinical conditions, such as sepsis, hypotension, shock, volume depletion, or rhabdomyolysis; and use of nephrotoxic agents, such as contrast media, aminoglycosides, chemotherapy drugs, or NSAIDs.

Mixed results

Dr. Niemann noted that in a systematic review of possible interventions for protecting renal function in the perioperative period found little in the way of solid evidence to support the use of various interventions, including dopamine agonists or analogs, loop diuretics, mannitol, calcium inhibitors, angiotensin-converting enzyme (ACE) inhibitors, N-acetylcysteine in contrast studies or surgery, or sodium bicarbonate (Cochrane Database of Syst. Rev. 2013;9:CD003590 [doi:10.1002/14651858.CD003590.pub]).

"The long and the short of it is that no interventions have definitely been shown to make a big difference in randomized trials," he said.

Nonetheless, to prevent further loss of renal function in at-risk patients, clinicians should optimize modifiable variables, such as blood pressure, and discontinue nephrotoxic medications, such as NSAIDs.

In addition, the perioperative team should strive to better control acidosis, anemia, and hyperphosphatemia.

"I think what is really important is that you counsel the patient in the preop clinic," Dr. Niemann said.

Preoperative clinic staff should review the procedure and risks based on the presence and severity of the patient’s CKD and outline possible outcomes based on the best available evidence.

"We do it for the heart, but we don’t do it for the kidney," he commented.

During surgery, the team should be aware of the risks of a potential "second hit" – that is, an acute injury on top of chronic disease, and after surgery, clinicians should monitor for the known risk factors, such as sepsis and infection, he said.

Dr. Niemann reported no relevant conflicts.

SCOTTSDALE, ARIZ. – Optimal management of patients with chronic kidney disease involves knowing what can be modified, understanding that much is uncertain, and having the wisdom to know the difference, suggested an anesthesiologist at a meeting on perioperative medicine sponsored by the University of Miami.

"There is a lot to be done in terms of evaluation of chronic kidney disease and also defining interventions," said Dr. Claus U. Niemann, professor of anesthesia and surgery at the University of California, San Francisco.

Kidney disease is identified either by markers of function such as glomerular filtration rate (GFR), markers of damage such as proteinuria, and markers of volume sense, such as edema, ascites, and urinary sodium excretion.

None of these measures is particularly accurate at measuring disease, however. For example, GFR is not observed directly but estimated from creatinine clearance, which is produced by the body in varying amounts daily and which depends on muscle mass, so that values for a young, muscular man will be higher than those of a small, older woman, Dr. Niemann noted.

In addition, even in people without kidney disease, GFR declines gradually with age, from about 116 mL/min per 1.73 m² for people in their 20s, to about 75 mL/min per 1.73 m² in those aged 70 years and older.

In 2002, the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) developed a five-stage classification for chronic kidney disease (CKD), based on GFR, with CKD defined as either a GFR of less than 60 mL/min per 1.73 m² for more than 3 months or evidence of kidney damage for more than 3 months, based on the presence of abnormalities such as proteinuria. The classification notes that a combination of GFR less than 60 mL/min per 1.73 m² and proteinuria is prognostic.

The classification includes moderately and severely reduced GFR, with respective rates of 30-59 and 15-29 mL/min per 1.73 m², respectively, and end-stage renal disease, with a GFR less than 15 mL/min per 1.73 m² or a need for dialysis,

The most common cause of CKD is diabetic nephropathy or hypertensive nephrosclerosis, which account for 67% of all cases. About 1 in 5 or 1 in 6 Americans has some form of CKD, and the problem can be lifelong, Dr. Niemann said.

Risk stratification

The goal of perioperative management of patients with CKD is to prevent further renal impairment from acute kidney injury, a rapid reduction in kidney function as measured by a significant rise in serum creatinine levels or reduction in urine output within 48 hours of exposure.

Approximately 5%-7% of all hospitalized patients experience some degree of acute kidney injury and changes in serum creatinine of only 0.3 mg/dL have been associated with greater length of stay and increased morbidity and mortality, Dr. Niemann said.

"What is really necessary is that we do perioperative risk stratification. We want to identify the subset of patients who are at risk, we can do tests potentially, and we want to understand what the procedure is, put it in the context of the patient and his renal disease, and then hopefully define a plan and get him to surgery," Dr. Niemann said.

Defining perioperative renal risk involves determining as best as possible the extent of renal insufficiency or CKD, the etiology of the kidney disease (including severity and complications), and the risk of loss of kidney function from the planned or urgent/emergent surgery. The preop clinical team should also know where the patient will be discharged after surgery (home, ICU, floor).

Risk factors for in-hospital acute renal failure include baseline risks, such as age, diabetes, heart or liver failure, and male sex; acute clinical conditions, such as sepsis, hypotension, shock, volume depletion, or rhabdomyolysis; and use of nephrotoxic agents, such as contrast media, aminoglycosides, chemotherapy drugs, or NSAIDs.

Mixed results

Dr. Niemann noted that in a systematic review of possible interventions for protecting renal function in the perioperative period found little in the way of solid evidence to support the use of various interventions, including dopamine agonists or analogs, loop diuretics, mannitol, calcium inhibitors, angiotensin-converting enzyme (ACE) inhibitors, N-acetylcysteine in contrast studies or surgery, or sodium bicarbonate (Cochrane Database of Syst. Rev. 2013;9:CD003590 [doi:10.1002/14651858.CD003590.pub]).

"The long and the short of it is that no interventions have definitely been shown to make a big difference in randomized trials," he said.

Nonetheless, to prevent further loss of renal function in at-risk patients, clinicians should optimize modifiable variables, such as blood pressure, and discontinue nephrotoxic medications, such as NSAIDs.

In addition, the perioperative team should strive to better control acidosis, anemia, and hyperphosphatemia.

"I think what is really important is that you counsel the patient in the preop clinic," Dr. Niemann said.

Preoperative clinic staff should review the procedure and risks based on the presence and severity of the patient’s CKD and outline possible outcomes based on the best available evidence.

"We do it for the heart, but we don’t do it for the kidney," he commented.

During surgery, the team should be aware of the risks of a potential "second hit" – that is, an acute injury on top of chronic disease, and after surgery, clinicians should monitor for the known risk factors, such as sepsis and infection, he said.

Dr. Niemann reported no relevant conflicts.

SCOTTSDALE, ARIZ. – Optimal management of patients with chronic kidney disease involves knowing what can be modified, understanding that much is uncertain, and having the wisdom to know the difference, suggested an anesthesiologist at a meeting on perioperative medicine sponsored by the University of Miami.

"There is a lot to be done in terms of evaluation of chronic kidney disease and also defining interventions," said Dr. Claus U. Niemann, professor of anesthesia and surgery at the University of California, San Francisco.

Kidney disease is identified either by markers of function such as glomerular filtration rate (GFR), markers of damage such as proteinuria, and markers of volume sense, such as edema, ascites, and urinary sodium excretion.

None of these measures is particularly accurate at measuring disease, however. For example, GFR is not observed directly but estimated from creatinine clearance, which is produced by the body in varying amounts daily and which depends on muscle mass, so that values for a young, muscular man will be higher than those of a small, older woman, Dr. Niemann noted.

In addition, even in people without kidney disease, GFR declines gradually with age, from about 116 mL/min per 1.73 m² for people in their 20s, to about 75 mL/min per 1.73 m² in those aged 70 years and older.

In 2002, the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) developed a five-stage classification for chronic kidney disease (CKD), based on GFR, with CKD defined as either a GFR of less than 60 mL/min per 1.73 m² for more than 3 months or evidence of kidney damage for more than 3 months, based on the presence of abnormalities such as proteinuria. The classification notes that a combination of GFR less than 60 mL/min per 1.73 m² and proteinuria is prognostic.

The classification includes moderately and severely reduced GFR, with respective rates of 30-59 and 15-29 mL/min per 1.73 m², respectively, and end-stage renal disease, with a GFR less than 15 mL/min per 1.73 m² or a need for dialysis,

The most common cause of CKD is diabetic nephropathy or hypertensive nephrosclerosis, which account for 67% of all cases. About 1 in 5 or 1 in 6 Americans has some form of CKD, and the problem can be lifelong, Dr. Niemann said.

Risk stratification

The goal of perioperative management of patients with CKD is to prevent further renal impairment from acute kidney injury, a rapid reduction in kidney function as measured by a significant rise in serum creatinine levels or reduction in urine output within 48 hours of exposure.

Approximately 5%-7% of all hospitalized patients experience some degree of acute kidney injury and changes in serum creatinine of only 0.3 mg/dL have been associated with greater length of stay and increased morbidity and mortality, Dr. Niemann said.

"What is really necessary is that we do perioperative risk stratification. We want to identify the subset of patients who are at risk, we can do tests potentially, and we want to understand what the procedure is, put it in the context of the patient and his renal disease, and then hopefully define a plan and get him to surgery," Dr. Niemann said.

Defining perioperative renal risk involves determining as best as possible the extent of renal insufficiency or CKD, the etiology of the kidney disease (including severity and complications), and the risk of loss of kidney function from the planned or urgent/emergent surgery. The preop clinical team should also know where the patient will be discharged after surgery (home, ICU, floor).

Risk factors for in-hospital acute renal failure include baseline risks, such as age, diabetes, heart or liver failure, and male sex; acute clinical conditions, such as sepsis, hypotension, shock, volume depletion, or rhabdomyolysis; and use of nephrotoxic agents, such as contrast media, aminoglycosides, chemotherapy drugs, or NSAIDs.

Mixed results

Dr. Niemann noted that in a systematic review of possible interventions for protecting renal function in the perioperative period found little in the way of solid evidence to support the use of various interventions, including dopamine agonists or analogs, loop diuretics, mannitol, calcium inhibitors, angiotensin-converting enzyme (ACE) inhibitors, N-acetylcysteine in contrast studies or surgery, or sodium bicarbonate (Cochrane Database of Syst. Rev. 2013;9:CD003590 [doi:10.1002/14651858.CD003590.pub]).

"The long and the short of it is that no interventions have definitely been shown to make a big difference in randomized trials," he said.

Nonetheless, to prevent further loss of renal function in at-risk patients, clinicians should optimize modifiable variables, such as blood pressure, and discontinue nephrotoxic medications, such as NSAIDs.

In addition, the perioperative team should strive to better control acidosis, anemia, and hyperphosphatemia.

"I think what is really important is that you counsel the patient in the preop clinic," Dr. Niemann said.

Preoperative clinic staff should review the procedure and risks based on the presence and severity of the patient’s CKD and outline possible outcomes based on the best available evidence.

"We do it for the heart, but we don’t do it for the kidney," he commented.

During surgery, the team should be aware of the risks of a potential "second hit" – that is, an acute injury on top of chronic disease, and after surgery, clinicians should monitor for the known risk factors, such as sepsis and infection, he said.

Dr. Niemann reported no relevant conflicts.

Men who had glomerular disease as children were at increased risk for developing hypertension as adults, according to a study published in JAMA.

Dr. Asaf Vivante and his colleagues studied 38,144 healthy men in the Staff Periodic Examination Center (SPEC) of the Israeli Defense Forces Medical Corps, 264 of whom had a medical history of resolved childhood glomerular disease.

©decade3d/thinkstockphotos.com

All participants had a baseline evaluation at age 17, during which the diagnosis of resolved childhood glomerular disease (including childhood acute glomerulonephritis and nephrotic syndrome) was determined. Men with unresolved childhood glomerular disease, hypertension, diabetes, active rheumatic diseases, or any other kidney or urinary tract disorders were excluded. SPEC follow-up visits occurred until hypertension diagnosis, retirement from service, or Dec. 31, 2010, whichever came first.

At a mean follow-up of 18 years, 2,856 men developed hypertension. Of men with a history of resolved childhood glomerular disease, 13.6% had hypertension as adults, compared with 7.4% who had no childhood kidney disease (hazard ratio, 1.67; 95% confidence interval, 1.20-2.31; P = .002 when adjusted for age and body mass index) (JAMA 2014;311:1155-7).

The researchers cited a few limitations of the study, including a lack of information on the exact glomerular histopathologic injury during childhood and the young age of the study population at the end of follow-up.

Database access was provided by the Israeli Defense Forces Medical Corps. One coauthor reported receiving travel reimbursement from the European Cooperation in Science and Technology. No other disclosures were reported.

[email protected]

Men who had glomerular disease as children were at increased risk for developing hypertension as adults, according to a study published in JAMA.

Dr. Asaf Vivante and his colleagues studied 38,144 healthy men in the Staff Periodic Examination Center (SPEC) of the Israeli Defense Forces Medical Corps, 264 of whom had a medical history of resolved childhood glomerular disease.

©decade3d/thinkstockphotos.com

All participants had a baseline evaluation at age 17, during which the diagnosis of resolved childhood glomerular disease (including childhood acute glomerulonephritis and nephrotic syndrome) was determined. Men with unresolved childhood glomerular disease, hypertension, diabetes, active rheumatic diseases, or any other kidney or urinary tract disorders were excluded. SPEC follow-up visits occurred until hypertension diagnosis, retirement from service, or Dec. 31, 2010, whichever came first.

At a mean follow-up of 18 years, 2,856 men developed hypertension. Of men with a history of resolved childhood glomerular disease, 13.6% had hypertension as adults, compared with 7.4% who had no childhood kidney disease (hazard ratio, 1.67; 95% confidence interval, 1.20-2.31; P = .002 when adjusted for age and body mass index) (JAMA 2014;311:1155-7).

The researchers cited a few limitations of the study, including a lack of information on the exact glomerular histopathologic injury during childhood and the young age of the study population at the end of follow-up.

Database access was provided by the Israeli Defense Forces Medical Corps. One coauthor reported receiving travel reimbursement from the European Cooperation in Science and Technology. No other disclosures were reported.

[email protected]

Men who had glomerular disease as children were at increased risk for developing hypertension as adults, according to a study published in JAMA.

Dr. Asaf Vivante and his colleagues studied 38,144 healthy men in the Staff Periodic Examination Center (SPEC) of the Israeli Defense Forces Medical Corps, 264 of whom had a medical history of resolved childhood glomerular disease.

©decade3d/thinkstockphotos.com

All participants had a baseline evaluation at age 17, during which the diagnosis of resolved childhood glomerular disease (including childhood acute glomerulonephritis and nephrotic syndrome) was determined. Men with unresolved childhood glomerular disease, hypertension, diabetes, active rheumatic diseases, or any other kidney or urinary tract disorders were excluded. SPEC follow-up visits occurred until hypertension diagnosis, retirement from service, or Dec. 31, 2010, whichever came first.

At a mean follow-up of 18 years, 2,856 men developed hypertension. Of men with a history of resolved childhood glomerular disease, 13.6% had hypertension as adults, compared with 7.4% who had no childhood kidney disease (hazard ratio, 1.67; 95% confidence interval, 1.20-2.31; P = .002 when adjusted for age and body mass index) (JAMA 2014;311:1155-7).

The researchers cited a few limitations of the study, including a lack of information on the exact glomerular histopathologic injury during childhood and the young age of the study population at the end of follow-up.

Database access was provided by the Israeli Defense Forces Medical Corps. One coauthor reported receiving travel reimbursement from the European Cooperation in Science and Technology. No other disclosures were reported.

[email protected]