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No improvements in left ventricular function with metformin after myocardial infarction
Major finding: Treatment with metformin after STEMI had no significant impact on LVEF or on the incidence of major cardiac events in nondiabetic...
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Aleglitazar failed to reduce cardiovascular events in type 2 diabetes
Major finding: Aleglitazar failed to improve cardiovascular outcomes when compared with placebo and was linked with an increased risk of adverse...
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Persistent lymphocytosis with ibrutinib does not indicate early relapse
Major finding: Patients with chronic lymphocytic leukemia who experienced persistent lymphocytosis associated with ibrutinib treatment did not...
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Cell-penetrating domain improves therapeutic cancer vaccine potency
Major finding: A cell-penetrating, domain-fused melanoma antigen showed more rapid and efficient penetration of the dendritic cell membrane than...
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Natalizumab mobilizes latent JC virus in mononuclear cells in MS
Major finding: Of 23 MS patients with cell-associated JC virus viremia, 14 tested seronegative for antibodies against the virus.Data source: A...
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First estimates of multidrug-resistant tuberculosis in children made
Major finding: A study has estimated nearly 32,000 children developed multidrug-resistant tuberculosis in 2010, finding the risk of multidrug-...
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Glycerol phenylbutyrate reduces hepatic encephalopathy events in cirrhosis
Major finding: Glycerol phenylbutyrate significantly reduces the number of cirrhosis patients experiencing hepatic encephalopathy and the time to...
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Plasma biomarker panel predicts amnestic MCI or Alzheimer’s
Major finding: A panel of 10 plasma lipid biomarkers can predict the development of either amnestic mild cognitive impairment or Alzheimer’s...
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Stem cell transplantation effective in aggressive relapsing-remitting MS
Major finding: Autologous hematopoietic stem cell transplantation in multiple sclerosis showed a 5-year, relapse-free survival rate of 87% and...
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TNF inhibitors reduce coronary artery disease risk in rheumatoid arthritis
Major finding: Treatment with TNF-alpha inhibitors more than halves the risk of coronary artery disease in patients with rheumatoid arthritis, in...
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Aggressive secondary squamous carcinoma appeared during BRAF inhibitor targeted therapy
Major finding: A woman undergoing BRAF inhibitor targeted therapy for advanced melanoma has presented with invasive spindle cell squamous...
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Postsurgical withdrawal of antiepileptic drugs raises only short-term seizure risk
Major finding: Two years after surgery, 69% of patients whose medication was discontinued at 1 year were completely seizure free, compared with 72...
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Increased mortality persists in drug-resistant epilepsy
Major finding: Drug-resistant epilepsy is associated with an increase in mortality (standardized mortality ratio, 2.4), especially among...
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Microvascular complications increase with diabetes duration but not age
Major finding: In ADVANCE, 7.5% of patients with disease duration of less than 5 years had a history of major microvascular disease, as did 18.6%...