Brian F. Mandell, MD, PhD

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Majid M. Mughal, MD
Departments of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation, Cleveland, Ohio

Karen James, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Kay Stelmach, RN
Departments of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Omar A. Minai, MD
Departments of Pulmonary and Critical Care Medicine,  The Cleveland Clinic Foundation, Cleveland, Ohio

Correspondence: Omar A. Minai, MD, Department of Pulmonary and Critical Care Medicine, A90, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; email: [email protected]

Dr. Minai has indicated that he has been a consultant to Actelion Pharmaceuticals.

All other authors have indicated that they have no commercial affiliations or interests that pose a potential conflict of interest with this article.

Majid M. Mughal, MD
Departments of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation, Cleveland, Ohio

Karen James, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Kay Stelmach, RN
Departments of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Omar A. Minai, MD
Departments of Pulmonary and Critical Care Medicine,  The Cleveland Clinic Foundation, Cleveland, Ohio

Correspondence: Omar A. Minai, MD, Department of Pulmonary and Critical Care Medicine, A90, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; email: [email protected]

Dr. Minai has indicated that he has been a consultant to Actelion Pharmaceuticals.

All other authors have indicated that they have no commercial affiliations or interests that pose a potential conflict of interest with this article.

Majid M. Mughal, MD
Departments of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation, Cleveland, Ohio

Karen James, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Kay Stelmach, RN
Departments of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio

Omar A. Minai, MD
Departments of Pulmonary and Critical Care Medicine,  The Cleveland Clinic Foundation, Cleveland, Ohio

Correspondence: Omar A. Minai, MD, Department of Pulmonary and Critical Care Medicine, A90, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; email: [email protected]

Dr. Minai has indicated that he has been a consultant to Actelion Pharmaceuticals.

All other authors have indicated that they have no commercial affiliations or interests that pose a potential conflict of interest with this article.

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, and Senior Associate Program Director, Internal Medicine Residency Program, The Cleveland Clinic; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Cleveland Clinic Journal of Medicine, NA32, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected] 

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, and Senior Associate Program Director, Internal Medicine Residency Program, The Cleveland Clinic; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Cleveland Clinic Journal of Medicine, NA32, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected] 

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, and Senior Associate Program Director, Internal Medicine Residency Program, The Cleveland Clinic; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Cleveland Clinic Journal of Medicine, NA32, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected] 

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, and Senior Associate Program Director, Internal Medicine Residency Program, The Cleveland Clinic; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, FACR, Cleveland Clinic Journal of Medicine, NA32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected] 

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, and Senior Associate Program Director, Internal Medicine Residency Program, The Cleveland Clinic; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, FACR, Cleveland Clinic Journal of Medicine, NA32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected] 

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Disease, and Senior Associate Program Director, Internal Medicine Residency Program, The Cleveland Clinic; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, FACR, Cleveland Clinic Journal of Medicine, NA32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected] 

John D. Clough, MD
Editor in Chief

Brian F. Mandell, MD, PhD
Deputy Editor

John D. Clough, MD
Editor in Chief

Brian F. Mandell, MD, PhD
Deputy Editor

John D. Clough, MD
Editor in Chief

Brian F. Mandell, MD, PhD
Deputy Editor