I Don't Think We're in the Adult Inpatient Unit

Article Type
Changed
Mon, 01/02/2017 - 19:34
Display Headline
Toto, I don't think we're on the adult inpatient unit anymore

The March issue of the Journal of Hospital Medicine represents a landmark for pediatric hospital medicine (PHM), with 100% of the original research content devoted to pediatrics. Since the days of the National Association of Inpatient Physicians, pediatric hospitalists have consistently constituted 8% to 10% of the membership of the Society of Hospital Medicine (SHM). SHM has always welcomed pediatrics and pediatricians into the community of hospital medicine. A pediatrician has sat on the board since the founding of the National Association of Inpatient Physicians, and for the past 3 years, there has been a formal pediatric board seat. The Hospitalist has consistently included pediatric content with program descriptions and literature reviews. This past July, more than 325 pediatric hospitalists gathered in Denver for the largest PHM meeting ever, a 4‐day event trisponsored by SHM, the American Academy of Pediatrics (AAP), and the Academic Pediatric Association (APA).

As pediatric hospitalists, we have prospered by following the successes of adult hospitalists. We have flattered/emmitated our adult colleagues with pediatric voluntary referral policies, core competencies, salary surveys, fellowship programs, and quality improvement projects. In other areas, pediatrics has set trends for (adult) hospital medicine. Pediatrics developed the medical home concept. We zealously advocate for family‐centered rounds. (Imagine actually rounding in the room with the patient, family, nurse, and physician. It certainly beats flipping cards in the conference room)! Pediatricians have developed global fee codes for evaluation and management services (albeit limited to neonatal and pediatric critical care). As evidenced by the trisponsored meeting mentioned previously and the Pediatric Research in Inpatient Settings Network, we have created collaborative relationships among the pediatric academic (APA), professional (AAP), and hospitalist organizations (SHM) that serve as models for other disciplines and their respective sandboxes.

Research and publications are where we most lag behind our adult colleagues and where the most work needs to be done for us to achieve legitimacy as practitioners and as a discipline. This issue of the Journal of Hospital Medicine is a harbinger of more pediatric content to come, with topics that run the gamut of PHM. Woolford et al.1 highlight clinical, public health, and public policy issues with their analysis of the increased costs and morbidity associated with obesity and inpatient hospitalizations. Wilkes et al.2 explore the logistic issues surrounding influenza testing. As is frequently true for hospitalists, our expertise is not purely clinical: Is oseltamvir effective and, if so, in what age groups? That question is probably best left to the infectious disease community. Rather, Wilkes et al. highlight both the provider and system issues involved in reliably and expeditiously obtaining, reporting, and communicating flu antigen test results so that clinicians and families have the opportunity to consider oseltamvir use within the first 48 hours of disease. Odetola et al.'s3 analysis of a Michigan administrative data set suggests that morbidity, length of stay, and resource utilization are decreased for patients who ultimately require pediatric critical care when these patients are directly transferred from the emergency room to a facility with a pediatric intensive care unit (PICU) in comparison with the morbidity, length of stay, and resource utilization of patients who are initially admitted to the ward from the emergency room and then transferred to a facility with a PICU. This study lacks the rigor of prospectively collected physiological data and would probably never receive institutional review board approval for randomization, but it certainly raises key questions about appropriate transfer criteria for patients cared for in hospitals without a PICU. This is a key quality concern for pediatric hospitalists practicing in smaller, community hospital settings.

The 2 most controversial articles in this pediatric inpatient potpourri are the studies conducted by Freed and Kelly examining pediatric hospitalist training, practice, and career goals4 and PHM fellowship programs.5 These studies are part of a 6‐perspective analysis of pediatric hospitalists/PHM requested by the American Board of Pediatrics (ABP) to provide background to the ABP as it begins to grapple with its role in certifying pediatricians whose primary practice is inpatient pediatrics. A previously published study analyzed the perspective of PHM group leaders.6 The remaining studies assess the perspectives of residency program directors, department chairs, and hospital leaders.

Not surprisingly, these 3 articles46 tend to be more critical of the PHM movement and its current state than are articles and commentaries written by those of us who are practicing hospitalists. As a hospitalist, my initial reaction was to focus on the studies' shortcomings. The methods seemed flawed, the criticisms seemed unwarranted, and the study limitations seemed underappreciated. Aside from the fellowship study, which surveyed the entire n = 8 universe of PHM fellowship programs, the group leader and hospitalist surveys suffer from a selection bias. Sampling for these studies was based on hospital size and type. Although this sampling strategy is appropriate for comparing programs across hospitals, it fails to account for programs of different sizes in different settings. It is not the best sampling strategy for a denominator of all pediatric hospitalists. For example, community hospital programs without residents are often much bigger than academic programs with residents. Community pediatric hospitalists are likely underrepresented in Freed's survey.4 From a study design standpoint, it does not appear that specific a priori hypotheses were generated when subgroups were compared. Rather, one suspects that every possible comparison was analyzed. Thus, the percent differences from one group to another are best considered descriptive rather than rigorously statistically significant at a p < 0.05 level. Some criticisms addressed to hospitalists apply to all pediatricians. Given the current emphasis on quality assessment, wouldn't most office‐based pediatricians (and particularly group leaders) believe that they need extra training in this field? When less than 50% of hospitals require practitioners in established subboarded specialties to be board‐certified to maintain hospital privileges,7 is it surprising to see that privileging standards vary for pediatric hospitalists?

However, nitpicking these studies is a defensive response that does a disservice both to the reports and more importantly to the PHM community as a whole and to the children, parents, and colleagues that we serve. There is no denying that we are a young, evolving field with significant inter‐institutional and at times intra‐institutional variability. All of us in the PHM community, leaders and lurkers, need to rise to the challenges offered by comprehensive analysis. Freed's sample of 431 hospitalists4 is significantly larger than the sample of 265 hospitalist participants in the latest Pediatric Research in Inpatient Settings survey.8 The perceptions of external observers are crucial; it would be a mistake to dismiss their findings or to ignore their interpretations and criticisms.

Certainly none would challenge the variability of practice revealed in Freed's analyses.46 Remember, if you've seen one pediatric hospital medicine program, you've seen ONE pediatric hospital medicine program. Some may see this variability as a weakness; others may see it as a strength. We must be equally receptive to other less‐flattering observations, data, and conclusions included in these reports to the ABP. All programs target seamless communication with referring physicians, but hospitalists and referring physicians alike agree that we do not achieve it, as evidenced by the work of Harlan et al.9 in this issue. SHM is taking the lead in developing performance standards for transitions of care and has created best discharge practices for the geriatric population.10 Similarly, we in the PHM community would do well to ramp up our self‐assessment and quality improvement activities. Our recusal from Centers for Medicare and Medicaid Services reporting requirements for (adult) inpatient quality metrics does not excuse us from pursuing voluntary, rigorous, transparent, public reporting on pediatric quality indicators. As Freed et al.6 clearly implied, the public and payers expect this of us. No doubt, if we do not first propose and implement our own standards, external standards will be imposed upon us.

Aside from the question of mandatory fellowship training for hospitalists, does the vision implied in the studies commissioned by the ABP vary significantly from the challenges to PHM that Sandy Melzer11 presented at his keynote address at the Denver meeting? Melzer used strategic planning principles to outline a future vision for PHM, including the following:

  • Harm is eliminated from the inpatient setting.

  • Inpatient care is evidence‐based for all conditions treated.

  • Hospital care is highly coordinated, especially for children with chronic conditions.

  • A robust research agenda supports all aspects of inpatient care.

Is not the work done by the SHM and APA to develop core competencies for PHM an effort to define our field and identify (uniform) expectations? Do not the criteria for designation as a fellow of hospital medicine (5 years as a practicing hospitalist; 2 national meetings; and a minimum combination of leadership, teamwork, and quality improvement activities)12 serve to recognize the commitment and accomplishments that distinguish a true hospitalist practicing systems‐based hospital medicine from a physician who simply works in the hospital?

There is no need for pediatric hospitalists to respond defensively to the hospitalist studies commissioned by the ABP. In fact, Freed46 has done us a favor by adding dimension and texture to the preliminary outlines of what it means for PHM to be ultimately successful. Both Freed and Melzer11 are describing the same path. As hospitalists, we tend to take pride in how far we have already come along this adventure. External observers such as Freed remind of us of how far we still need to go. Either way, Dorothy Gale, MD, pediatric hospitalist, has a relatively well‐identified yellow brick road to follow with specific challenges and charges to meet. What is unclear is whether formal acknowledgment will be awarded at the end of this journey and, if so, what form it will take. Options include (1) recognition of focused practice in hospital medicine with maintenance of certification, (2) SHM fellowship, (3) a traditionally boarded subspecialty, or (4) all of the above.

Any formal designation will be of secondary importance. Remember, the wizard did not change anything when he bestowed the diploma, the heart‐shaped testimonial, and the medal of valor. Like the scarecrow, tin man, and lion, all the qualities that we need for success as pediatric hospitalists are already within us. No wizard's pronouncements will help us provide better care to our patients. Change will come from working together on shared goals with mutual support along our common path. Look to the Journal of Hospital Medicine for frequent updates on the journey. See you in the Emerald City.

Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
145-148
Sections
Article PDF
Article PDF

The March issue of the Journal of Hospital Medicine represents a landmark for pediatric hospital medicine (PHM), with 100% of the original research content devoted to pediatrics. Since the days of the National Association of Inpatient Physicians, pediatric hospitalists have consistently constituted 8% to 10% of the membership of the Society of Hospital Medicine (SHM). SHM has always welcomed pediatrics and pediatricians into the community of hospital medicine. A pediatrician has sat on the board since the founding of the National Association of Inpatient Physicians, and for the past 3 years, there has been a formal pediatric board seat. The Hospitalist has consistently included pediatric content with program descriptions and literature reviews. This past July, more than 325 pediatric hospitalists gathered in Denver for the largest PHM meeting ever, a 4‐day event trisponsored by SHM, the American Academy of Pediatrics (AAP), and the Academic Pediatric Association (APA).

As pediatric hospitalists, we have prospered by following the successes of adult hospitalists. We have flattered/emmitated our adult colleagues with pediatric voluntary referral policies, core competencies, salary surveys, fellowship programs, and quality improvement projects. In other areas, pediatrics has set trends for (adult) hospital medicine. Pediatrics developed the medical home concept. We zealously advocate for family‐centered rounds. (Imagine actually rounding in the room with the patient, family, nurse, and physician. It certainly beats flipping cards in the conference room)! Pediatricians have developed global fee codes for evaluation and management services (albeit limited to neonatal and pediatric critical care). As evidenced by the trisponsored meeting mentioned previously and the Pediatric Research in Inpatient Settings Network, we have created collaborative relationships among the pediatric academic (APA), professional (AAP), and hospitalist organizations (SHM) that serve as models for other disciplines and their respective sandboxes.

Research and publications are where we most lag behind our adult colleagues and where the most work needs to be done for us to achieve legitimacy as practitioners and as a discipline. This issue of the Journal of Hospital Medicine is a harbinger of more pediatric content to come, with topics that run the gamut of PHM. Woolford et al.1 highlight clinical, public health, and public policy issues with their analysis of the increased costs and morbidity associated with obesity and inpatient hospitalizations. Wilkes et al.2 explore the logistic issues surrounding influenza testing. As is frequently true for hospitalists, our expertise is not purely clinical: Is oseltamvir effective and, if so, in what age groups? That question is probably best left to the infectious disease community. Rather, Wilkes et al. highlight both the provider and system issues involved in reliably and expeditiously obtaining, reporting, and communicating flu antigen test results so that clinicians and families have the opportunity to consider oseltamvir use within the first 48 hours of disease. Odetola et al.'s3 analysis of a Michigan administrative data set suggests that morbidity, length of stay, and resource utilization are decreased for patients who ultimately require pediatric critical care when these patients are directly transferred from the emergency room to a facility with a pediatric intensive care unit (PICU) in comparison with the morbidity, length of stay, and resource utilization of patients who are initially admitted to the ward from the emergency room and then transferred to a facility with a PICU. This study lacks the rigor of prospectively collected physiological data and would probably never receive institutional review board approval for randomization, but it certainly raises key questions about appropriate transfer criteria for patients cared for in hospitals without a PICU. This is a key quality concern for pediatric hospitalists practicing in smaller, community hospital settings.

The 2 most controversial articles in this pediatric inpatient potpourri are the studies conducted by Freed and Kelly examining pediatric hospitalist training, practice, and career goals4 and PHM fellowship programs.5 These studies are part of a 6‐perspective analysis of pediatric hospitalists/PHM requested by the American Board of Pediatrics (ABP) to provide background to the ABP as it begins to grapple with its role in certifying pediatricians whose primary practice is inpatient pediatrics. A previously published study analyzed the perspective of PHM group leaders.6 The remaining studies assess the perspectives of residency program directors, department chairs, and hospital leaders.

Not surprisingly, these 3 articles46 tend to be more critical of the PHM movement and its current state than are articles and commentaries written by those of us who are practicing hospitalists. As a hospitalist, my initial reaction was to focus on the studies' shortcomings. The methods seemed flawed, the criticisms seemed unwarranted, and the study limitations seemed underappreciated. Aside from the fellowship study, which surveyed the entire n = 8 universe of PHM fellowship programs, the group leader and hospitalist surveys suffer from a selection bias. Sampling for these studies was based on hospital size and type. Although this sampling strategy is appropriate for comparing programs across hospitals, it fails to account for programs of different sizes in different settings. It is not the best sampling strategy for a denominator of all pediatric hospitalists. For example, community hospital programs without residents are often much bigger than academic programs with residents. Community pediatric hospitalists are likely underrepresented in Freed's survey.4 From a study design standpoint, it does not appear that specific a priori hypotheses were generated when subgroups were compared. Rather, one suspects that every possible comparison was analyzed. Thus, the percent differences from one group to another are best considered descriptive rather than rigorously statistically significant at a p < 0.05 level. Some criticisms addressed to hospitalists apply to all pediatricians. Given the current emphasis on quality assessment, wouldn't most office‐based pediatricians (and particularly group leaders) believe that they need extra training in this field? When less than 50% of hospitals require practitioners in established subboarded specialties to be board‐certified to maintain hospital privileges,7 is it surprising to see that privileging standards vary for pediatric hospitalists?

However, nitpicking these studies is a defensive response that does a disservice both to the reports and more importantly to the PHM community as a whole and to the children, parents, and colleagues that we serve. There is no denying that we are a young, evolving field with significant inter‐institutional and at times intra‐institutional variability. All of us in the PHM community, leaders and lurkers, need to rise to the challenges offered by comprehensive analysis. Freed's sample of 431 hospitalists4 is significantly larger than the sample of 265 hospitalist participants in the latest Pediatric Research in Inpatient Settings survey.8 The perceptions of external observers are crucial; it would be a mistake to dismiss their findings or to ignore their interpretations and criticisms.

Certainly none would challenge the variability of practice revealed in Freed's analyses.46 Remember, if you've seen one pediatric hospital medicine program, you've seen ONE pediatric hospital medicine program. Some may see this variability as a weakness; others may see it as a strength. We must be equally receptive to other less‐flattering observations, data, and conclusions included in these reports to the ABP. All programs target seamless communication with referring physicians, but hospitalists and referring physicians alike agree that we do not achieve it, as evidenced by the work of Harlan et al.9 in this issue. SHM is taking the lead in developing performance standards for transitions of care and has created best discharge practices for the geriatric population.10 Similarly, we in the PHM community would do well to ramp up our self‐assessment and quality improvement activities. Our recusal from Centers for Medicare and Medicaid Services reporting requirements for (adult) inpatient quality metrics does not excuse us from pursuing voluntary, rigorous, transparent, public reporting on pediatric quality indicators. As Freed et al.6 clearly implied, the public and payers expect this of us. No doubt, if we do not first propose and implement our own standards, external standards will be imposed upon us.

Aside from the question of mandatory fellowship training for hospitalists, does the vision implied in the studies commissioned by the ABP vary significantly from the challenges to PHM that Sandy Melzer11 presented at his keynote address at the Denver meeting? Melzer used strategic planning principles to outline a future vision for PHM, including the following:

  • Harm is eliminated from the inpatient setting.

  • Inpatient care is evidence‐based for all conditions treated.

  • Hospital care is highly coordinated, especially for children with chronic conditions.

  • A robust research agenda supports all aspects of inpatient care.

Is not the work done by the SHM and APA to develop core competencies for PHM an effort to define our field and identify (uniform) expectations? Do not the criteria for designation as a fellow of hospital medicine (5 years as a practicing hospitalist; 2 national meetings; and a minimum combination of leadership, teamwork, and quality improvement activities)12 serve to recognize the commitment and accomplishments that distinguish a true hospitalist practicing systems‐based hospital medicine from a physician who simply works in the hospital?

There is no need for pediatric hospitalists to respond defensively to the hospitalist studies commissioned by the ABP. In fact, Freed46 has done us a favor by adding dimension and texture to the preliminary outlines of what it means for PHM to be ultimately successful. Both Freed and Melzer11 are describing the same path. As hospitalists, we tend to take pride in how far we have already come along this adventure. External observers such as Freed remind of us of how far we still need to go. Either way, Dorothy Gale, MD, pediatric hospitalist, has a relatively well‐identified yellow brick road to follow with specific challenges and charges to meet. What is unclear is whether formal acknowledgment will be awarded at the end of this journey and, if so, what form it will take. Options include (1) recognition of focused practice in hospital medicine with maintenance of certification, (2) SHM fellowship, (3) a traditionally boarded subspecialty, or (4) all of the above.

Any formal designation will be of secondary importance. Remember, the wizard did not change anything when he bestowed the diploma, the heart‐shaped testimonial, and the medal of valor. Like the scarecrow, tin man, and lion, all the qualities that we need for success as pediatric hospitalists are already within us. No wizard's pronouncements will help us provide better care to our patients. Change will come from working together on shared goals with mutual support along our common path. Look to the Journal of Hospital Medicine for frequent updates on the journey. See you in the Emerald City.

The March issue of the Journal of Hospital Medicine represents a landmark for pediatric hospital medicine (PHM), with 100% of the original research content devoted to pediatrics. Since the days of the National Association of Inpatient Physicians, pediatric hospitalists have consistently constituted 8% to 10% of the membership of the Society of Hospital Medicine (SHM). SHM has always welcomed pediatrics and pediatricians into the community of hospital medicine. A pediatrician has sat on the board since the founding of the National Association of Inpatient Physicians, and for the past 3 years, there has been a formal pediatric board seat. The Hospitalist has consistently included pediatric content with program descriptions and literature reviews. This past July, more than 325 pediatric hospitalists gathered in Denver for the largest PHM meeting ever, a 4‐day event trisponsored by SHM, the American Academy of Pediatrics (AAP), and the Academic Pediatric Association (APA).

As pediatric hospitalists, we have prospered by following the successes of adult hospitalists. We have flattered/emmitated our adult colleagues with pediatric voluntary referral policies, core competencies, salary surveys, fellowship programs, and quality improvement projects. In other areas, pediatrics has set trends for (adult) hospital medicine. Pediatrics developed the medical home concept. We zealously advocate for family‐centered rounds. (Imagine actually rounding in the room with the patient, family, nurse, and physician. It certainly beats flipping cards in the conference room)! Pediatricians have developed global fee codes for evaluation and management services (albeit limited to neonatal and pediatric critical care). As evidenced by the trisponsored meeting mentioned previously and the Pediatric Research in Inpatient Settings Network, we have created collaborative relationships among the pediatric academic (APA), professional (AAP), and hospitalist organizations (SHM) that serve as models for other disciplines and their respective sandboxes.

Research and publications are where we most lag behind our adult colleagues and where the most work needs to be done for us to achieve legitimacy as practitioners and as a discipline. This issue of the Journal of Hospital Medicine is a harbinger of more pediatric content to come, with topics that run the gamut of PHM. Woolford et al.1 highlight clinical, public health, and public policy issues with their analysis of the increased costs and morbidity associated with obesity and inpatient hospitalizations. Wilkes et al.2 explore the logistic issues surrounding influenza testing. As is frequently true for hospitalists, our expertise is not purely clinical: Is oseltamvir effective and, if so, in what age groups? That question is probably best left to the infectious disease community. Rather, Wilkes et al. highlight both the provider and system issues involved in reliably and expeditiously obtaining, reporting, and communicating flu antigen test results so that clinicians and families have the opportunity to consider oseltamvir use within the first 48 hours of disease. Odetola et al.'s3 analysis of a Michigan administrative data set suggests that morbidity, length of stay, and resource utilization are decreased for patients who ultimately require pediatric critical care when these patients are directly transferred from the emergency room to a facility with a pediatric intensive care unit (PICU) in comparison with the morbidity, length of stay, and resource utilization of patients who are initially admitted to the ward from the emergency room and then transferred to a facility with a PICU. This study lacks the rigor of prospectively collected physiological data and would probably never receive institutional review board approval for randomization, but it certainly raises key questions about appropriate transfer criteria for patients cared for in hospitals without a PICU. This is a key quality concern for pediatric hospitalists practicing in smaller, community hospital settings.

The 2 most controversial articles in this pediatric inpatient potpourri are the studies conducted by Freed and Kelly examining pediatric hospitalist training, practice, and career goals4 and PHM fellowship programs.5 These studies are part of a 6‐perspective analysis of pediatric hospitalists/PHM requested by the American Board of Pediatrics (ABP) to provide background to the ABP as it begins to grapple with its role in certifying pediatricians whose primary practice is inpatient pediatrics. A previously published study analyzed the perspective of PHM group leaders.6 The remaining studies assess the perspectives of residency program directors, department chairs, and hospital leaders.

Not surprisingly, these 3 articles46 tend to be more critical of the PHM movement and its current state than are articles and commentaries written by those of us who are practicing hospitalists. As a hospitalist, my initial reaction was to focus on the studies' shortcomings. The methods seemed flawed, the criticisms seemed unwarranted, and the study limitations seemed underappreciated. Aside from the fellowship study, which surveyed the entire n = 8 universe of PHM fellowship programs, the group leader and hospitalist surveys suffer from a selection bias. Sampling for these studies was based on hospital size and type. Although this sampling strategy is appropriate for comparing programs across hospitals, it fails to account for programs of different sizes in different settings. It is not the best sampling strategy for a denominator of all pediatric hospitalists. For example, community hospital programs without residents are often much bigger than academic programs with residents. Community pediatric hospitalists are likely underrepresented in Freed's survey.4 From a study design standpoint, it does not appear that specific a priori hypotheses were generated when subgroups were compared. Rather, one suspects that every possible comparison was analyzed. Thus, the percent differences from one group to another are best considered descriptive rather than rigorously statistically significant at a p < 0.05 level. Some criticisms addressed to hospitalists apply to all pediatricians. Given the current emphasis on quality assessment, wouldn't most office‐based pediatricians (and particularly group leaders) believe that they need extra training in this field? When less than 50% of hospitals require practitioners in established subboarded specialties to be board‐certified to maintain hospital privileges,7 is it surprising to see that privileging standards vary for pediatric hospitalists?

However, nitpicking these studies is a defensive response that does a disservice both to the reports and more importantly to the PHM community as a whole and to the children, parents, and colleagues that we serve. There is no denying that we are a young, evolving field with significant inter‐institutional and at times intra‐institutional variability. All of us in the PHM community, leaders and lurkers, need to rise to the challenges offered by comprehensive analysis. Freed's sample of 431 hospitalists4 is significantly larger than the sample of 265 hospitalist participants in the latest Pediatric Research in Inpatient Settings survey.8 The perceptions of external observers are crucial; it would be a mistake to dismiss their findings or to ignore their interpretations and criticisms.

Certainly none would challenge the variability of practice revealed in Freed's analyses.46 Remember, if you've seen one pediatric hospital medicine program, you've seen ONE pediatric hospital medicine program. Some may see this variability as a weakness; others may see it as a strength. We must be equally receptive to other less‐flattering observations, data, and conclusions included in these reports to the ABP. All programs target seamless communication with referring physicians, but hospitalists and referring physicians alike agree that we do not achieve it, as evidenced by the work of Harlan et al.9 in this issue. SHM is taking the lead in developing performance standards for transitions of care and has created best discharge practices for the geriatric population.10 Similarly, we in the PHM community would do well to ramp up our self‐assessment and quality improvement activities. Our recusal from Centers for Medicare and Medicaid Services reporting requirements for (adult) inpatient quality metrics does not excuse us from pursuing voluntary, rigorous, transparent, public reporting on pediatric quality indicators. As Freed et al.6 clearly implied, the public and payers expect this of us. No doubt, if we do not first propose and implement our own standards, external standards will be imposed upon us.

Aside from the question of mandatory fellowship training for hospitalists, does the vision implied in the studies commissioned by the ABP vary significantly from the challenges to PHM that Sandy Melzer11 presented at his keynote address at the Denver meeting? Melzer used strategic planning principles to outline a future vision for PHM, including the following:

  • Harm is eliminated from the inpatient setting.

  • Inpatient care is evidence‐based for all conditions treated.

  • Hospital care is highly coordinated, especially for children with chronic conditions.

  • A robust research agenda supports all aspects of inpatient care.

Is not the work done by the SHM and APA to develop core competencies for PHM an effort to define our field and identify (uniform) expectations? Do not the criteria for designation as a fellow of hospital medicine (5 years as a practicing hospitalist; 2 national meetings; and a minimum combination of leadership, teamwork, and quality improvement activities)12 serve to recognize the commitment and accomplishments that distinguish a true hospitalist practicing systems‐based hospital medicine from a physician who simply works in the hospital?

There is no need for pediatric hospitalists to respond defensively to the hospitalist studies commissioned by the ABP. In fact, Freed46 has done us a favor by adding dimension and texture to the preliminary outlines of what it means for PHM to be ultimately successful. Both Freed and Melzer11 are describing the same path. As hospitalists, we tend to take pride in how far we have already come along this adventure. External observers such as Freed remind of us of how far we still need to go. Either way, Dorothy Gale, MD, pediatric hospitalist, has a relatively well‐identified yellow brick road to follow with specific challenges and charges to meet. What is unclear is whether formal acknowledgment will be awarded at the end of this journey and, if so, what form it will take. Options include (1) recognition of focused practice in hospital medicine with maintenance of certification, (2) SHM fellowship, (3) a traditionally boarded subspecialty, or (4) all of the above.

Any formal designation will be of secondary importance. Remember, the wizard did not change anything when he bestowed the diploma, the heart‐shaped testimonial, and the medal of valor. Like the scarecrow, tin man, and lion, all the qualities that we need for success as pediatric hospitalists are already within us. No wizard's pronouncements will help us provide better care to our patients. Change will come from working together on shared goals with mutual support along our common path. Look to the Journal of Hospital Medicine for frequent updates on the journey. See you in the Emerald City.

Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
145-148
Page Number
145-148
Article Type
Display Headline
Toto, I don't think we're on the adult inpatient unit anymore
Display Headline
Toto, I don't think we're on the adult inpatient unit anymore
Sections
Article Source
Copyright © 2009 Society of Hospital Medicine
Disallow All Ads
Correspondence Location
E.L.M.O. Pediatrics, 1735 York Avenue, #23B, New York, NY 10128
Content Gating
Gated (full article locked unless allowed per User)
Gating Strategy
First Peek Free
Article PDF Media

Predictors of Smoking and Relapse

Article Type
Changed
Sun, 05/28/2017 - 21:53
Display Headline
Predictors of smoking cessation and relapse after hospitalization for acute coronary syndrome

Tobacco use in the United States is the chief avoidable cause of death in the United States.1 The health benefits of smoking cessation are widely known, including reductions in the risk for lung cancer, chronic obstructive pulmonary disease, and heart disease.2, 3 Particularly for patients with symptomatic coronary artery disease, smoking cessation reduces the risk of mortality by 30% to 50%.4, 5

Being hospitalized for a major cardiac event spurs many smokers to stop smoking. Acute and chronic health events are associated with a much lower likelihood of continued smoking, both immediately and over time. Cessation rates among smokers hospitalized for a cardiac condition, such as acute coronary syndrome (ACS), range from 31% without intervention to 60% with sustained intervention posthospitalization, at 1‐year follow‐up.610

Various studies have examined predictors of continued smoking among patients with heart disease. However, few studies have focused on prognostic factors in patients hospitalized for their heart condition, illustrating a gap in the literature. Factors found to affect smoking cessation rates have included: mood disorders, such as current or history of depression,6, 1113 a high level of state‐anxiety,13 and hostility or tensions;12 severity of disease, such as history of previous cardiac event,6, 9 history of smoking‐related pulmonary disease,6 severity of the cardiac disease,6, 12 having 1 or more risk factors for coronary artery disease other than smoking,14 or unstable angina;14 greater nicotine dependence or heavy smoking at index hospitalization;6, 9, 14, 15 and the presence of other smokers in the home/work environment.16

Data from a recently completed randomized controlled trial of a health behavior intervention within the context of hospital quality improvement provided the opportunity to study factors predictive of successfully quitting smoking in hospitalized cardiac patients. The description and results of that trial, called the Heart After Hospitalization Recovery Program (HARP), are reported elsewhere.17, 18 In summary, the health behavior intervention program studied in the trial was not successful in improving the smoking cessation rates above the control group receiving only the hospital quality improvement (QI) approach. Results of the QI intervention, the ACS Guidelines Applied to Practice (GAP) program, showed gains in survival that appeared to be due to better adherence to guidelines, which included a patient contract for behavior change.19, 20 Therefore, the purpose of this work is to describe all the preadmission smoking patients in the study, regardless of trial group assignment, and examine predictive factors for smoking cessation and relapse to smoking after their hospital discharge for ACS.

PATIENTS AND METHODS

The institutional review boards of the authors' university and each of the 5 participating hospitals approved the HARP study.

Settings and Subjects

Patients were recruited from 5 hospitals located in 2 adjacent counties in a Midwestern state. The 2 counties were similar: each had 1 major city surrounded by suburbs and outlying rural and farming areas, diverse populations with a minority population higher than the state average (20% versus 14.5%), a high unemployment rate (above 8%), and an industrial/manufacturing economic base.

Patient eligibility criteria included: admission to 1 of 5 participating study hospitals, a documented serum troponin I level greater than the upper limits of normal observed in each hospital, and a working diagnosis of ACS. Exclusion criteria included: discharge to any nonhome setting, possession of any significant mental/cognitive impairments, lack of a home telephone, or non‐English speaking. Trained nurse recruiters approached hospitalized patients, providing information on study participation and attempting to obtain consent. Recruitment occurred between January 14, 2002 and April 13, 2003. A mean number of 2.29 standard deviation (SD) 1.82 contacts were made with patients having elevated troponin levels to determine their actual eligibility.

Measures

Interview data were collected from patients at the following time points: shortly after hospital discharge (baseline), and 3 and 8 months postdischarge. Survey telephone calls lasted approximately 30 to 40 minutes and were conducted by trained survey researchers at the university's Institute for Public Policy and Social Research. Surveyors were blinded to the group assignment of the participants they were interviewing.

At the baseline interview, conducted between 1 and 4 weeks after discharge from the hospital (mean 14.11 9.6 days), patients answered questions of survey interviewers including demographic and background information, comorbid conditions (Charlson comorbidity index [CCI] method),21 history of depression, current depressive symptoms (Center for Epidemiological Studies‐Depression [CES‐D] tool)22, and tobacco use.

Smoking status at the time of hospitalization was established based on 2 sources of information: the medical record chart audits, and the baseline interview. The baseline interview asked Have you ever smoked tobacco? Respondents answering yes were asked: Do you smoke every day, some days, or not at all?; How many cigarettes do you now smoke per day on average?; and On average, when you smoked in the past 30 days, how many cigarettes did you smoke? Respondents who reported that they quit smoking were asked when they had quit. Comparing the time between the baseline interview and the original hospital admission, the research team could establish who quit by the time of the baseline interview, but had still been a smoker at the time of hospitalization. Therefore, this group of patients was considered smokers for the purpose of this study; defined as smoking at the time of hospitalization for this heart event. All other patients were treated as nonsmokers. Smoking status at hospitalization was then confirmed with the hospital medical record, which provided information on whether the patient was a current, ever, or never smoker, the years smoked, and the number of packs currently smoked per day.

In the subsequent 3‐month and 8‐month interviews, each patient's reported smoking status and frequency was reassessed through the items, Have there been any changes in your tobacco use in the past 3 months? and During the last month, have you smoked everyday, some days, or not at all? If the patient reported current smoking, then he/she was asked On the average, when you smoked during the past 30 days, about how many cigarettes did you smoke a day? If the patient reported quitting, he/she was asked How long ago did you quit smoking? Household smoking was assessed by the question In the past 30 days, has anyone, besides yourself, smoked cigarettes, cigars, or pipes anywhere inside your home?

Data Analysis

In addition to descriptive statistics characterizing the analysis sample, the analysis relies on multinomial logit regression models to predict who among the smoking ACS patients discharged would continue to smoke, would quit for the observation period, or would relapse.23, 24 Multinomial logit regression represents an extension of the more familiar binary logistic regression25 involving comparisons of all possible pairs of outcomes. Specifically, instead of employing separate logistic regression models to compare permanent quitters to continuing smokers, relapsers to continuing smoker, and permanent quitters to relapsers, these comparisons are contrasts in the multinomial model.

Thus, in addition to obtaining adjusted odds ratio (OR)s that take account of the simultaneous influence of all predictors, this analysis produces overall goodness‐of‐fit indicators and multivariate significance tests, which test whether coefficients associated with a particular independent variable have a simultaneous effect on the outcome across all categories. For instance, a multinomial P‐value of less than 0.05 for a subject's history of depression would indicate that such a history has a significant effect on whether or not subjects continue to smoke, quit for good, or relapse. The specific ORs and their associated significance levels then indicate if and to what degree prior depression affects each 2‐way contrast (quitters versus smokers, relapsers versus smokers, quitters versus relapsers). The analysis was conducted using the mlogit procedure of the STATA, 9.0 software package.26

RESULTS

Subjects

Of 719 consenting patients, 166 (23.1%) were initially assessed to be smokers based on their medical record documentation. Smoking status at hospitalization could not be verified and smoking status after hospitalization could not be determined for 15 patients who did not participate in any of the follow‐up interviews, therefore they were excluded. An additional 15 patients were excluded because of the lack of a second follow‐up interview, which would have allowed us to determine whether they quit smoking for at least 3 months or relapsed. Therefore, we include only the 136 cases with generally complete interview data in the current analysis. Table 1 depicts the demographic, medical, and smoking‐related characteristics of these patients.

Demographic and Clinical Characteristics of Smoking HARP Patients at Baseline Interview (Preintervention)
VariableNumber or Mean SDPercentage
  • NOTE: n = 136.

Age (years)53.32 9.52 
Gender  
Male8361
Female5339
White/nonwhite race  
White11282.4
Nonwhite/multiracial/other2417.6
Marital status  
Married8059.3
Divorced/separated/widowed5640.7
Work for pay or profit  
Yes7152.2
No6447.1
Missing10.7
Highest education  
High‐school diploma or less7958.1
Some college or more5741.9
Family income  
Less than $15,000 per year3626.5
$15,000 or more per year9066.2
No information107.4
Ejection fraction (EF)  
EF 35%1410.3
EF > 35%11080.9
Unmeasured128.8
Number of comorbid conditions1.79 1.81 
Number of persons living in household2.63 1.41 
Past diagnosis of depression  
Yes4029.4
No9670.6

Significant Predictors of Cessation and Relapse

Of the 136 smokers who were interviewed at baseline and completed the follow‐up surveys, 45 continued to smoke at baseline and at subsequent interviews in which they participated (33.1%) were defined as continuing smokers. Sixty‐five patients quit smoking (quitters) and remained nonsmokers for the time of observationat least 1 more interview wave or an additional 3 months (47.8% of respondents). Twenty‐six of the 136 (19.1%) were relapsers. They reported quitting smoking shortly after their hospitalization, but reported smoking again at either the 3‐month or 8‐month interview. Smoking again was defined as answering every day or some days to the question During the last month, have you smoked every day, some days, or not at all?).

Table 2 shows the cross‐tabulations and Table 3 shows the result from the multinominal regression analysis identifying significant predictors of quitting and relapsing as compared to continued smoking, relapsing versus quitting. Initially, the model included patient age (continuous variable), sex, years of education, race/ethnicity (other versus Caucasian) and insurance status (Medicare, Medicaid, employer‐based private insurance, other private insurance, no insurance) among the predictor variables, but they were eliminated from the model based on the nonsignificance of the likelihood ratio chi square test associated with each of them. In the final model, we retained only significant predictor variables, except for 1: membership in the study groups (intervention group with coaching, intervention group without coaching, control group). To ease interpretation, the table displays 3 columns of the adjusted ORs, comparing all 2‐way comparisons of outcomes. The third column, comparing relapsers and quitters, is technically redundant, as its ORs represent the ratios of the other 2 columns, but the values may be of interest to readers. The multinomial P‐values in the right‐hand column confirm that, with the sole exception of study group membership, every remaining independent variable is a significant predictor of smoking status after hospital discharge.

Cross‐Tabulations Comparing Smokers to Successful Quitters and Relapsers Among PostHospital Discharge Acute Coronary Syndrome Patients Who Smoked When They Entered the Hospital
Independent VariablesSmokers [n (%)]*Relapsers [n (%)]Quitters [n (%)]P‐Value
  • NOTE: n = 136; likelihood ratio 2 = 55.08; degrees of freedom = 14; P < 0.0001.

  • Smokers are defined as those who continued to smoke after the hospitalization.

  • Relapsers are defined as those who quit smoking after hospitalization but had begun smoking again by either the 3‐month or 8‐month interview.

  • Successful quitters are defined as those who quit smoking and remained quit for the observation period.

  • Significance tests associated with multiple category predictors.

Household income    
<$15,00021 (58)6 (17)9 (25) 
$15,000+22 (24)19 (21)59 (54)0.003
Study group    
QI only22 (37)13 (21)25 (42) 
QI‐plus HARP (coached)14 (27)10 (20)27 (53) 
QI‐plus HARP (not coached)9 (36)3 (12)13 (52)0.644
History of depression    
No30 (31)12 (13)54 (56) 
Yes14 (36)14 (36)11 (28)0.002
Smokers in household    
No19 (23)11 (14)51 (63) 
Yes26 (47)15 (27)14 (25)0.000
Intensity of smoking    
Moderate/heavy26 (29)13 (15)49 (56) 
Light19 (40)13 (27)16 (33)0.034
Multinomial Logistic Regression Comparing Smokers to Successful Quitters and Relapsers Among PostHospital Discharge Acute Coronary Syndrome Patients Who Smoked When They Entered the Hospital
Independent VariablesSuccessful Quitters* versus Smokers OR (95% CI)Relapsers versus Smokers OR (95% CI)Relapsers versus Successful Quitters* OR (95% CI)Multinomial P Value
  • NOTE: n = 136; likelihood ratio 2 = 55.08; degrees of freedom = 14; P < 0.0001; Bolded items indicate significant relationships.

  • Abbreviations: CI, confidence interval; OR, adjusted odds ratio.

  • Successful quitters are defined as those who quit smoking and remained quit for the observation period.

  • Smokers are defined as those who continued to smoke after the hospitalization.

  • Relapsers are defined as those who quit smoking after hospitalization but had begun smoking again by either the 3‐month or 8‐month interview.

  • Significance tests associated with multiple category predictors.

  • Reference category (comparison group in parentheses).

Household income ($15,000)   0.007
$15,000+4.72 (1.69‐12.87)3.38 (1.09‐9.97)1.72 (0.85‐3.46)0.005
Study group (intervention)   0.56
QI‐plus HARP (uncoached)0.86 (0.24‐3.05)0.46 (0.10‐2.65)0.53 (0.26‐1.09)0.65
QI only0.52 (0.19‐1.39)0.81 (0.28‐2.70)1.56 (0.85‐2.84)0.42
History of depression (yes)0.42 (0.16‐1.41)2.66 (1.02‐7.49)6.38 (2.34‐17.34)0.007
Smokers in household (yes)0.20 (0.08‐0.55)0.97 (0.32‐2.61)4.74 (1.57‐14.24)0.001
Intensity of smoking (moderate to heavy)    
Light0.20 (0.04‐0.99)1.29 (0.44‐3.56)0.16 (0.05‐0.57)0.08

As the data show, patients with higher household incomes have substantially higher odds of quitting than low‐income patients (OR = 4.72; P = 0.001); yet they also have greater odds of relapsing (OR = 3.38; P = 0.04). Patients with a history/past diagnosis of depression are not more likely to quit than those without a depression history; however, they have larger odds of relapsing back to smoking (ie, the OR for the comparison of relapsers versus smokers (OR = 2.66; P = 0.05) almost reaches the conventional significance level, while the OR for the contrast of relapsers versus quitters (OR = 6.38; P = 0.002) is significant and of substantial magnitude. By comparison, the presence of other smokers in a patient's household both lowers the odds of becoming a successful quitter (OR = 0.20; P = 0.001), and raises the odds of relapsing after initial quitting (OR = 4.74; P = 0.005). While lighter smokers (defined as <10 cigarettes a day) before hospitalization do not appear to be more successful in quitting than heavier smokers (defined as >20 cigarettes a day) (OR = 1.29; P = 0.62), they are less likely to relapse to smoking if they quit (OR = 0.16; P = 0.03).

Specific results relating to the telephone counseling intervention are found elsewhere.17, 18 However, we did include in Table 2 the specific results for the study groups to illustrate that the intervention program was not a factor predicting cessation. Analysis of the data using intention‐to‐treat (assuming all losses to follow‐up were continuing smokers) resulted in similar findings at the 8‐month follow‐up (2 = 2.635; degrees of freedom [df] = 2; P = 0.268).

DISCUSSION

The smoking cessation rate of 56.8% (n = 111; only those with 8‐month follow‐up) in this study population at 8 months compares favorably with the range of 31% to 60% shown in earlier studies of cardiac populations.610, 27 Assuming more conservatively that the survey nonresponders were all smokers yields a 46.3% quit rate (n = 136; all those with at least 1 follow‐up), which is within the range reported in the literature.

The intervention program was not a factor predicting cessation. Most posthospital follow‐up counseling is associated with increased smoking abstinence at follow‐up.28, 29 It is possible that the GAP in‐hospital QI initiative in these hospitals contributed to improving the cessation of smokers in both trial arms, thereby negating the effect of the counseling‐only option, although we did not specifically study the effect of the GAP intervention. It is also possible that we were underpowered to detect a statistically significant difference given our sample size of smokers.

Several characteristics were associated with successful smoking cessation in posthospitalized ACS patients. These included higher incomes, no other smokers in the household, and being a lighter smoker. We also found, however, that those with a history of depression, and heavier smokers also had higher rates of relapsing. As with previous research, our results support the evidence that heavier smokers have greater difficulty quitting smoking.6, 9, 14, 15 Heavier smoking indicates a greater nicotine addiction.27 However, 1 study of smoking cessation of smokers at a tertiary referral, cardiothoracic hospital found that smokers with greater pack years (eg, number of years smoked at an equivalent of 1 pack per day), had a higher likelihood of abstinence at a 12‐month follow‐up.30 More intense efforts are likely needed to assist smokers with a more significant addiction. Perhaps studies are needed to better understand the physiological and genetic mechanisms of nicotine addiction and effective treatment options for this group.

Our results also demonstrate that those with a history of depression were more likely to relapse. Several researchers have demonstrated that in patients with a history of depression, return of depressive symptoms upon a cessation attempt may precipitate relapse.28, 29 Current depressive symptoms, as measured by the CES‐D, were not associated with decreased rates of quitting or relapsing. After controlling for history of depression, the CES‐D score was no longer a predictor of quitting or relapsing in our data.

Similar to other studies, smokers in this study who reported having other smokers in the household had a more difficult time both quitting and remaining abstinent.16, 31 A related controversy concerns the efficacy of including (smoking and nonsmoking) family members in interventions to sustain longer‐term abstinence. Including family members has demonstrated efficacy in some research,3234 although the optimal means of involving family members in smoking cessation interventions has not yet been identified. Severity of cardiac disease (as measured by ejection fraction) and the presence of comorbid conditions were not found to be associated with smoking continuation or cessation. We did not find in this sample of ACS patients that smoking cessation rates increased with age during the follow‐up survey time points.

There are several limitations to our study. First, we did not biochemically validate self‐reported smoking cessation rates. However, it is generally found that self‐reports of cessation are accurate in research studies.35 Also participants may have incorrectly stated their quit rates due to recall bias. We were unable to fully capture use of smoking cessation pharmacotherapy (such as bupropion or nicotine replacement), which may have better explained success with cessation. Unfortunately, this is also not usually captured in the literature on studies of this nature. Last, since this study enrolled only cardiac patients in 2 similar community populations, these results may not be fully generalizable to other communities.

For smokers suffering from cardiac disease, there are few better ways to prevent a second heart event than quitting smoking. Judging from these results, there still remain a great number of hospitalized smokers who either choose to, or are unable to, successfully quit smoking, even after hospitalization for a serious cardiac event. Further research is needed to understand what individual motivating or household mechanisms may be best considered when encouraging this group of smokers to quit permanently.

Acknowledgements

Special thanks to Dr. Azfar Siddiqi for database management, Chrystal Price for data entry, and Camille Proden for chart abstraction and study recruitment. Supported by Agency for Health Research and Quality (AHRQ) grant number R01 HS 10531 (to M.H.‐R.).

References
  1. Mokdad AH,Marks JS,Stroup DF,Gerberding JL.Actual causes of death in the United States 2000.JAMA.2004;291(10):12381245.
  2. Goldstein MG,Niaura R.Methods to enhance smoking cessation after myocardial infarction.Med Clin North Am.2000;84(1):6380.
  3. Edwards R.The problem of tobacco smoking.BMJ.2004;328:217219.
  4. Wilhelmsen L.Effects of cessation of smoking after myocardial infarction.J Cardiovasc Risk.1998;5(3):173176.
  5. Wilson K,Gibson N,Willan A,Cook D.Effect of smoking cessation on mortality after myocardial infarction.Ann Intern Med.2000;160:939944.
  6. Attebring MF,Hartford M,Hjalmarson A,Caidahl K,Karlsson T,Herlitz J.Smoking habits and predictors of continued smoking in patients with acute coronary syndromes.JAdv Nurs.2004;46(6):614623.
  7. Hajek P,Taylor TZ,Mills P.Brief intervention during hospital admission to help patients to give up smoking after myocardial infarction and bypass surgery: randomised controlled trial.BMJ.2002;324(7329):8789.
  8. Pederson LL,Wanklin JM,Lefcoe NM.The effects of counseling on smoking cessation among patients hospitalized with chronic obstructive pulmonary disease: a randomized clinical trial.Int J Addict.1991;26(1):107119.
  9. Quist‐Paulsen P,Gallefoss F.Randomised controlled trial of smoking cessation intervention after admission for coronary heart disease.BMJ.2003;327(7426):12541257.
  10. van Berkel TF,Boersma H,De Baquer D,Deckers JW,Wood D.Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE Survey.Eur Heart J.1999;20(22):16301637.
  11. Mayou RA,Gill D,Thompson DR, et al.Depression and anxiety as predictors of outcome after myocardial infarction.Psychosom Med.2000;62(2):212219.
  12. Brummett BH,Babyak MA,Mark DC, et al.Predictors of smoking cessation in patients with a diagnosis of coronary artery disease.J Cardiopulm Rehabil.2002;22(3):143147.
  13. Huijbrechts IP,Duivenvoorden HJ,Deckers JW, et al.Modification of smoking habits five months after myocardial infarction: relationship with personality characteristics.J Psychosom Res.1996;40(4):369378.
  14. Hasdai D,Garratt KN,Grill DE, et al.Predictors of smoking cessation after percutaneous coronary revascularization.Mayo Clin Proc.1998;73(3):205209.
  15. Ong KC,Cheong GN,Prabhakaran L,Earnest A.Predictors of success in smoking cessation among hospitalized patients.Respirology.2005;10(1):6369.
  16. Chandola T,Head J,Bartley M.Socio‐demographic predictors of quitting smoking: how important are household factors.Addiction.2004;99(6):770777.
  17. Holtrop JS,Corser WD,Jones G,Brooks G,Holmes‐Rovner M,Stommel M.Health behavior goals of cardiac patients after hospitalization.Am J Health Behav.2006;30(4):387399.
  18. Holmes‐Rovner M,Stommel M,Corser WA, et al.Does outpatient telephone coaching add to hospital quality improvement following hospitalization for acute coronary syndrome?J Gen Intern Med.2008;23(9):14641470.
  19. Mehta R,Montoye C,Gallogly M, et al.Improving quality of care for acute myocardial infarction. The guidelines applied in practice (GAP) initiative.JAMA.2002;287(10):12691276.
  20. Mehta R,Montoye C,Gallogly M, et al.Improving quality of care for acute myocardial infarction.JAMA.2002;287(10):12691276.
  21. Charlson ME,Pompei P,Ales KL,MacKenzie CR.A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.J Chronic Dis.1987;40(5):373383.
  22. Devins G,Orme CM.Center for Epidemiologic Studies Depression Scale. In:Keyser DJ,Sweetland RC, eds.Test Critiques. Vol2.Kansas City, MO:Test Corporation;1985:144160.
  23. Agresti A.Categorical Data Analysis.New York, NY:Wiley 1990.
  24. Long JS.Regression Models for Categorical and Limited Dependent Variables.Thousand Oaks, CA:Sage;1997.
  25. Hosmer D,Lemeshow S.Applied Logistic Regression.New York, NY:John Wiley 1989.
  26. Stata Statistical Software: Release 9.College Station, TX:StataCorp LP;2005.
  27. van Berkel TF,Boersma H,De Baquer D,Deckers JW,Wood D.Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE Survey.Eur Heart J.1999;20(22):16301637.
  28. Rigotti NA,Munafo MR,Murphy MF,Stead LF.Interventions for smoking cessation in hospitalized patients.Cochrane Database Syst Rev.2003;(1):CD001837.
  29. France EK,Glasgow RE,Marcus AC.Smoking cessation interventions among hospitalized patients: what have we learned.Prev Med.2001;32(4):376388.
  30. Fung PR,Snape‐Jenkinson SL,Godfrey MT, et al.Effectiveness of hospital‐based smoking cessation.Chest.2005;128(1):216223.
  31. Miller CE,Ratner PA,Johnson JL.Reducing cardiovascular risk: identifying predictors of smoking relapse.Can J Cardiovasc Nurs.2003;13(3):712.
  32. Curry SJ,Hollis J,Bush T, et al.A randomized trial of a family‐based smoking prevention intervention in managed care.Prev Med.2003;37:617626.
  33. Park EW,Schultz JK,Tudiver F,Campbell T,Becker L.Enhancing partner support to improve smoking cessation.Cochrane Database Syst Rev.2004;(3):CD002928.
  34. Rohrbaugh MJ,Shoham V,Trost S,Muramoto M,Cate RM,Leischow S.Couple dynamics of change‐resistant smoking: toward a family consultation model.Fam Process.2001;40:115131.
  35. Caraballo RS,Giovino GA,Pechacek TF,Mowery PD.Factors associated with discrepancies between self‐reports on cigarette smoking and measured serum cotinine levels among persons aged 17 years or older: Third National Health and Nutrition Examination Survey, 1988–1994.Am J Epidemiol.2001;153(8):807814.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
E3-E9
Legacy Keywords
heart disease, hospital inpatients, smoking cessation
Sections
Article PDF
Article PDF

Tobacco use in the United States is the chief avoidable cause of death in the United States.1 The health benefits of smoking cessation are widely known, including reductions in the risk for lung cancer, chronic obstructive pulmonary disease, and heart disease.2, 3 Particularly for patients with symptomatic coronary artery disease, smoking cessation reduces the risk of mortality by 30% to 50%.4, 5

Being hospitalized for a major cardiac event spurs many smokers to stop smoking. Acute and chronic health events are associated with a much lower likelihood of continued smoking, both immediately and over time. Cessation rates among smokers hospitalized for a cardiac condition, such as acute coronary syndrome (ACS), range from 31% without intervention to 60% with sustained intervention posthospitalization, at 1‐year follow‐up.610

Various studies have examined predictors of continued smoking among patients with heart disease. However, few studies have focused on prognostic factors in patients hospitalized for their heart condition, illustrating a gap in the literature. Factors found to affect smoking cessation rates have included: mood disorders, such as current or history of depression,6, 1113 a high level of state‐anxiety,13 and hostility or tensions;12 severity of disease, such as history of previous cardiac event,6, 9 history of smoking‐related pulmonary disease,6 severity of the cardiac disease,6, 12 having 1 or more risk factors for coronary artery disease other than smoking,14 or unstable angina;14 greater nicotine dependence or heavy smoking at index hospitalization;6, 9, 14, 15 and the presence of other smokers in the home/work environment.16

Data from a recently completed randomized controlled trial of a health behavior intervention within the context of hospital quality improvement provided the opportunity to study factors predictive of successfully quitting smoking in hospitalized cardiac patients. The description and results of that trial, called the Heart After Hospitalization Recovery Program (HARP), are reported elsewhere.17, 18 In summary, the health behavior intervention program studied in the trial was not successful in improving the smoking cessation rates above the control group receiving only the hospital quality improvement (QI) approach. Results of the QI intervention, the ACS Guidelines Applied to Practice (GAP) program, showed gains in survival that appeared to be due to better adherence to guidelines, which included a patient contract for behavior change.19, 20 Therefore, the purpose of this work is to describe all the preadmission smoking patients in the study, regardless of trial group assignment, and examine predictive factors for smoking cessation and relapse to smoking after their hospital discharge for ACS.

PATIENTS AND METHODS

The institutional review boards of the authors' university and each of the 5 participating hospitals approved the HARP study.

Settings and Subjects

Patients were recruited from 5 hospitals located in 2 adjacent counties in a Midwestern state. The 2 counties were similar: each had 1 major city surrounded by suburbs and outlying rural and farming areas, diverse populations with a minority population higher than the state average (20% versus 14.5%), a high unemployment rate (above 8%), and an industrial/manufacturing economic base.

Patient eligibility criteria included: admission to 1 of 5 participating study hospitals, a documented serum troponin I level greater than the upper limits of normal observed in each hospital, and a working diagnosis of ACS. Exclusion criteria included: discharge to any nonhome setting, possession of any significant mental/cognitive impairments, lack of a home telephone, or non‐English speaking. Trained nurse recruiters approached hospitalized patients, providing information on study participation and attempting to obtain consent. Recruitment occurred between January 14, 2002 and April 13, 2003. A mean number of 2.29 standard deviation (SD) 1.82 contacts were made with patients having elevated troponin levels to determine their actual eligibility.

Measures

Interview data were collected from patients at the following time points: shortly after hospital discharge (baseline), and 3 and 8 months postdischarge. Survey telephone calls lasted approximately 30 to 40 minutes and were conducted by trained survey researchers at the university's Institute for Public Policy and Social Research. Surveyors were blinded to the group assignment of the participants they were interviewing.

At the baseline interview, conducted between 1 and 4 weeks after discharge from the hospital (mean 14.11 9.6 days), patients answered questions of survey interviewers including demographic and background information, comorbid conditions (Charlson comorbidity index [CCI] method),21 history of depression, current depressive symptoms (Center for Epidemiological Studies‐Depression [CES‐D] tool)22, and tobacco use.

Smoking status at the time of hospitalization was established based on 2 sources of information: the medical record chart audits, and the baseline interview. The baseline interview asked Have you ever smoked tobacco? Respondents answering yes were asked: Do you smoke every day, some days, or not at all?; How many cigarettes do you now smoke per day on average?; and On average, when you smoked in the past 30 days, how many cigarettes did you smoke? Respondents who reported that they quit smoking were asked when they had quit. Comparing the time between the baseline interview and the original hospital admission, the research team could establish who quit by the time of the baseline interview, but had still been a smoker at the time of hospitalization. Therefore, this group of patients was considered smokers for the purpose of this study; defined as smoking at the time of hospitalization for this heart event. All other patients were treated as nonsmokers. Smoking status at hospitalization was then confirmed with the hospital medical record, which provided information on whether the patient was a current, ever, or never smoker, the years smoked, and the number of packs currently smoked per day.

In the subsequent 3‐month and 8‐month interviews, each patient's reported smoking status and frequency was reassessed through the items, Have there been any changes in your tobacco use in the past 3 months? and During the last month, have you smoked everyday, some days, or not at all? If the patient reported current smoking, then he/she was asked On the average, when you smoked during the past 30 days, about how many cigarettes did you smoke a day? If the patient reported quitting, he/she was asked How long ago did you quit smoking? Household smoking was assessed by the question In the past 30 days, has anyone, besides yourself, smoked cigarettes, cigars, or pipes anywhere inside your home?

Data Analysis

In addition to descriptive statistics characterizing the analysis sample, the analysis relies on multinomial logit regression models to predict who among the smoking ACS patients discharged would continue to smoke, would quit for the observation period, or would relapse.23, 24 Multinomial logit regression represents an extension of the more familiar binary logistic regression25 involving comparisons of all possible pairs of outcomes. Specifically, instead of employing separate logistic regression models to compare permanent quitters to continuing smokers, relapsers to continuing smoker, and permanent quitters to relapsers, these comparisons are contrasts in the multinomial model.

Thus, in addition to obtaining adjusted odds ratio (OR)s that take account of the simultaneous influence of all predictors, this analysis produces overall goodness‐of‐fit indicators and multivariate significance tests, which test whether coefficients associated with a particular independent variable have a simultaneous effect on the outcome across all categories. For instance, a multinomial P‐value of less than 0.05 for a subject's history of depression would indicate that such a history has a significant effect on whether or not subjects continue to smoke, quit for good, or relapse. The specific ORs and their associated significance levels then indicate if and to what degree prior depression affects each 2‐way contrast (quitters versus smokers, relapsers versus smokers, quitters versus relapsers). The analysis was conducted using the mlogit procedure of the STATA, 9.0 software package.26

RESULTS

Subjects

Of 719 consenting patients, 166 (23.1%) were initially assessed to be smokers based on their medical record documentation. Smoking status at hospitalization could not be verified and smoking status after hospitalization could not be determined for 15 patients who did not participate in any of the follow‐up interviews, therefore they were excluded. An additional 15 patients were excluded because of the lack of a second follow‐up interview, which would have allowed us to determine whether they quit smoking for at least 3 months or relapsed. Therefore, we include only the 136 cases with generally complete interview data in the current analysis. Table 1 depicts the demographic, medical, and smoking‐related characteristics of these patients.

Demographic and Clinical Characteristics of Smoking HARP Patients at Baseline Interview (Preintervention)
VariableNumber or Mean SDPercentage
  • NOTE: n = 136.

Age (years)53.32 9.52 
Gender  
Male8361
Female5339
White/nonwhite race  
White11282.4
Nonwhite/multiracial/other2417.6
Marital status  
Married8059.3
Divorced/separated/widowed5640.7
Work for pay or profit  
Yes7152.2
No6447.1
Missing10.7
Highest education  
High‐school diploma or less7958.1
Some college or more5741.9
Family income  
Less than $15,000 per year3626.5
$15,000 or more per year9066.2
No information107.4
Ejection fraction (EF)  
EF 35%1410.3
EF > 35%11080.9
Unmeasured128.8
Number of comorbid conditions1.79 1.81 
Number of persons living in household2.63 1.41 
Past diagnosis of depression  
Yes4029.4
No9670.6

Significant Predictors of Cessation and Relapse

Of the 136 smokers who were interviewed at baseline and completed the follow‐up surveys, 45 continued to smoke at baseline and at subsequent interviews in which they participated (33.1%) were defined as continuing smokers. Sixty‐five patients quit smoking (quitters) and remained nonsmokers for the time of observationat least 1 more interview wave or an additional 3 months (47.8% of respondents). Twenty‐six of the 136 (19.1%) were relapsers. They reported quitting smoking shortly after their hospitalization, but reported smoking again at either the 3‐month or 8‐month interview. Smoking again was defined as answering every day or some days to the question During the last month, have you smoked every day, some days, or not at all?).

Table 2 shows the cross‐tabulations and Table 3 shows the result from the multinominal regression analysis identifying significant predictors of quitting and relapsing as compared to continued smoking, relapsing versus quitting. Initially, the model included patient age (continuous variable), sex, years of education, race/ethnicity (other versus Caucasian) and insurance status (Medicare, Medicaid, employer‐based private insurance, other private insurance, no insurance) among the predictor variables, but they were eliminated from the model based on the nonsignificance of the likelihood ratio chi square test associated with each of them. In the final model, we retained only significant predictor variables, except for 1: membership in the study groups (intervention group with coaching, intervention group without coaching, control group). To ease interpretation, the table displays 3 columns of the adjusted ORs, comparing all 2‐way comparisons of outcomes. The third column, comparing relapsers and quitters, is technically redundant, as its ORs represent the ratios of the other 2 columns, but the values may be of interest to readers. The multinomial P‐values in the right‐hand column confirm that, with the sole exception of study group membership, every remaining independent variable is a significant predictor of smoking status after hospital discharge.

Cross‐Tabulations Comparing Smokers to Successful Quitters and Relapsers Among PostHospital Discharge Acute Coronary Syndrome Patients Who Smoked When They Entered the Hospital
Independent VariablesSmokers [n (%)]*Relapsers [n (%)]Quitters [n (%)]P‐Value
  • NOTE: n = 136; likelihood ratio 2 = 55.08; degrees of freedom = 14; P < 0.0001.

  • Smokers are defined as those who continued to smoke after the hospitalization.

  • Relapsers are defined as those who quit smoking after hospitalization but had begun smoking again by either the 3‐month or 8‐month interview.

  • Successful quitters are defined as those who quit smoking and remained quit for the observation period.

  • Significance tests associated with multiple category predictors.

Household income    
<$15,00021 (58)6 (17)9 (25) 
$15,000+22 (24)19 (21)59 (54)0.003
Study group    
QI only22 (37)13 (21)25 (42) 
QI‐plus HARP (coached)14 (27)10 (20)27 (53) 
QI‐plus HARP (not coached)9 (36)3 (12)13 (52)0.644
History of depression    
No30 (31)12 (13)54 (56) 
Yes14 (36)14 (36)11 (28)0.002
Smokers in household    
No19 (23)11 (14)51 (63) 
Yes26 (47)15 (27)14 (25)0.000
Intensity of smoking    
Moderate/heavy26 (29)13 (15)49 (56) 
Light19 (40)13 (27)16 (33)0.034
Multinomial Logistic Regression Comparing Smokers to Successful Quitters and Relapsers Among PostHospital Discharge Acute Coronary Syndrome Patients Who Smoked When They Entered the Hospital
Independent VariablesSuccessful Quitters* versus Smokers OR (95% CI)Relapsers versus Smokers OR (95% CI)Relapsers versus Successful Quitters* OR (95% CI)Multinomial P Value
  • NOTE: n = 136; likelihood ratio 2 = 55.08; degrees of freedom = 14; P < 0.0001; Bolded items indicate significant relationships.

  • Abbreviations: CI, confidence interval; OR, adjusted odds ratio.

  • Successful quitters are defined as those who quit smoking and remained quit for the observation period.

  • Smokers are defined as those who continued to smoke after the hospitalization.

  • Relapsers are defined as those who quit smoking after hospitalization but had begun smoking again by either the 3‐month or 8‐month interview.

  • Significance tests associated with multiple category predictors.

  • Reference category (comparison group in parentheses).

Household income ($15,000)   0.007
$15,000+4.72 (1.69‐12.87)3.38 (1.09‐9.97)1.72 (0.85‐3.46)0.005
Study group (intervention)   0.56
QI‐plus HARP (uncoached)0.86 (0.24‐3.05)0.46 (0.10‐2.65)0.53 (0.26‐1.09)0.65
QI only0.52 (0.19‐1.39)0.81 (0.28‐2.70)1.56 (0.85‐2.84)0.42
History of depression (yes)0.42 (0.16‐1.41)2.66 (1.02‐7.49)6.38 (2.34‐17.34)0.007
Smokers in household (yes)0.20 (0.08‐0.55)0.97 (0.32‐2.61)4.74 (1.57‐14.24)0.001
Intensity of smoking (moderate to heavy)    
Light0.20 (0.04‐0.99)1.29 (0.44‐3.56)0.16 (0.05‐0.57)0.08

As the data show, patients with higher household incomes have substantially higher odds of quitting than low‐income patients (OR = 4.72; P = 0.001); yet they also have greater odds of relapsing (OR = 3.38; P = 0.04). Patients with a history/past diagnosis of depression are not more likely to quit than those without a depression history; however, they have larger odds of relapsing back to smoking (ie, the OR for the comparison of relapsers versus smokers (OR = 2.66; P = 0.05) almost reaches the conventional significance level, while the OR for the contrast of relapsers versus quitters (OR = 6.38; P = 0.002) is significant and of substantial magnitude. By comparison, the presence of other smokers in a patient's household both lowers the odds of becoming a successful quitter (OR = 0.20; P = 0.001), and raises the odds of relapsing after initial quitting (OR = 4.74; P = 0.005). While lighter smokers (defined as <10 cigarettes a day) before hospitalization do not appear to be more successful in quitting than heavier smokers (defined as >20 cigarettes a day) (OR = 1.29; P = 0.62), they are less likely to relapse to smoking if they quit (OR = 0.16; P = 0.03).

Specific results relating to the telephone counseling intervention are found elsewhere.17, 18 However, we did include in Table 2 the specific results for the study groups to illustrate that the intervention program was not a factor predicting cessation. Analysis of the data using intention‐to‐treat (assuming all losses to follow‐up were continuing smokers) resulted in similar findings at the 8‐month follow‐up (2 = 2.635; degrees of freedom [df] = 2; P = 0.268).

DISCUSSION

The smoking cessation rate of 56.8% (n = 111; only those with 8‐month follow‐up) in this study population at 8 months compares favorably with the range of 31% to 60% shown in earlier studies of cardiac populations.610, 27 Assuming more conservatively that the survey nonresponders were all smokers yields a 46.3% quit rate (n = 136; all those with at least 1 follow‐up), which is within the range reported in the literature.

The intervention program was not a factor predicting cessation. Most posthospital follow‐up counseling is associated with increased smoking abstinence at follow‐up.28, 29 It is possible that the GAP in‐hospital QI initiative in these hospitals contributed to improving the cessation of smokers in both trial arms, thereby negating the effect of the counseling‐only option, although we did not specifically study the effect of the GAP intervention. It is also possible that we were underpowered to detect a statistically significant difference given our sample size of smokers.

Several characteristics were associated with successful smoking cessation in posthospitalized ACS patients. These included higher incomes, no other smokers in the household, and being a lighter smoker. We also found, however, that those with a history of depression, and heavier smokers also had higher rates of relapsing. As with previous research, our results support the evidence that heavier smokers have greater difficulty quitting smoking.6, 9, 14, 15 Heavier smoking indicates a greater nicotine addiction.27 However, 1 study of smoking cessation of smokers at a tertiary referral, cardiothoracic hospital found that smokers with greater pack years (eg, number of years smoked at an equivalent of 1 pack per day), had a higher likelihood of abstinence at a 12‐month follow‐up.30 More intense efforts are likely needed to assist smokers with a more significant addiction. Perhaps studies are needed to better understand the physiological and genetic mechanisms of nicotine addiction and effective treatment options for this group.

Our results also demonstrate that those with a history of depression were more likely to relapse. Several researchers have demonstrated that in patients with a history of depression, return of depressive symptoms upon a cessation attempt may precipitate relapse.28, 29 Current depressive symptoms, as measured by the CES‐D, were not associated with decreased rates of quitting or relapsing. After controlling for history of depression, the CES‐D score was no longer a predictor of quitting or relapsing in our data.

Similar to other studies, smokers in this study who reported having other smokers in the household had a more difficult time both quitting and remaining abstinent.16, 31 A related controversy concerns the efficacy of including (smoking and nonsmoking) family members in interventions to sustain longer‐term abstinence. Including family members has demonstrated efficacy in some research,3234 although the optimal means of involving family members in smoking cessation interventions has not yet been identified. Severity of cardiac disease (as measured by ejection fraction) and the presence of comorbid conditions were not found to be associated with smoking continuation or cessation. We did not find in this sample of ACS patients that smoking cessation rates increased with age during the follow‐up survey time points.

There are several limitations to our study. First, we did not biochemically validate self‐reported smoking cessation rates. However, it is generally found that self‐reports of cessation are accurate in research studies.35 Also participants may have incorrectly stated their quit rates due to recall bias. We were unable to fully capture use of smoking cessation pharmacotherapy (such as bupropion or nicotine replacement), which may have better explained success with cessation. Unfortunately, this is also not usually captured in the literature on studies of this nature. Last, since this study enrolled only cardiac patients in 2 similar community populations, these results may not be fully generalizable to other communities.

For smokers suffering from cardiac disease, there are few better ways to prevent a second heart event than quitting smoking. Judging from these results, there still remain a great number of hospitalized smokers who either choose to, or are unable to, successfully quit smoking, even after hospitalization for a serious cardiac event. Further research is needed to understand what individual motivating or household mechanisms may be best considered when encouraging this group of smokers to quit permanently.

Acknowledgements

Special thanks to Dr. Azfar Siddiqi for database management, Chrystal Price for data entry, and Camille Proden for chart abstraction and study recruitment. Supported by Agency for Health Research and Quality (AHRQ) grant number R01 HS 10531 (to M.H.‐R.).

Tobacco use in the United States is the chief avoidable cause of death in the United States.1 The health benefits of smoking cessation are widely known, including reductions in the risk for lung cancer, chronic obstructive pulmonary disease, and heart disease.2, 3 Particularly for patients with symptomatic coronary artery disease, smoking cessation reduces the risk of mortality by 30% to 50%.4, 5

Being hospitalized for a major cardiac event spurs many smokers to stop smoking. Acute and chronic health events are associated with a much lower likelihood of continued smoking, both immediately and over time. Cessation rates among smokers hospitalized for a cardiac condition, such as acute coronary syndrome (ACS), range from 31% without intervention to 60% with sustained intervention posthospitalization, at 1‐year follow‐up.610

Various studies have examined predictors of continued smoking among patients with heart disease. However, few studies have focused on prognostic factors in patients hospitalized for their heart condition, illustrating a gap in the literature. Factors found to affect smoking cessation rates have included: mood disorders, such as current or history of depression,6, 1113 a high level of state‐anxiety,13 and hostility or tensions;12 severity of disease, such as history of previous cardiac event,6, 9 history of smoking‐related pulmonary disease,6 severity of the cardiac disease,6, 12 having 1 or more risk factors for coronary artery disease other than smoking,14 or unstable angina;14 greater nicotine dependence or heavy smoking at index hospitalization;6, 9, 14, 15 and the presence of other smokers in the home/work environment.16

Data from a recently completed randomized controlled trial of a health behavior intervention within the context of hospital quality improvement provided the opportunity to study factors predictive of successfully quitting smoking in hospitalized cardiac patients. The description and results of that trial, called the Heart After Hospitalization Recovery Program (HARP), are reported elsewhere.17, 18 In summary, the health behavior intervention program studied in the trial was not successful in improving the smoking cessation rates above the control group receiving only the hospital quality improvement (QI) approach. Results of the QI intervention, the ACS Guidelines Applied to Practice (GAP) program, showed gains in survival that appeared to be due to better adherence to guidelines, which included a patient contract for behavior change.19, 20 Therefore, the purpose of this work is to describe all the preadmission smoking patients in the study, regardless of trial group assignment, and examine predictive factors for smoking cessation and relapse to smoking after their hospital discharge for ACS.

PATIENTS AND METHODS

The institutional review boards of the authors' university and each of the 5 participating hospitals approved the HARP study.

Settings and Subjects

Patients were recruited from 5 hospitals located in 2 adjacent counties in a Midwestern state. The 2 counties were similar: each had 1 major city surrounded by suburbs and outlying rural and farming areas, diverse populations with a minority population higher than the state average (20% versus 14.5%), a high unemployment rate (above 8%), and an industrial/manufacturing economic base.

Patient eligibility criteria included: admission to 1 of 5 participating study hospitals, a documented serum troponin I level greater than the upper limits of normal observed in each hospital, and a working diagnosis of ACS. Exclusion criteria included: discharge to any nonhome setting, possession of any significant mental/cognitive impairments, lack of a home telephone, or non‐English speaking. Trained nurse recruiters approached hospitalized patients, providing information on study participation and attempting to obtain consent. Recruitment occurred between January 14, 2002 and April 13, 2003. A mean number of 2.29 standard deviation (SD) 1.82 contacts were made with patients having elevated troponin levels to determine their actual eligibility.

Measures

Interview data were collected from patients at the following time points: shortly after hospital discharge (baseline), and 3 and 8 months postdischarge. Survey telephone calls lasted approximately 30 to 40 minutes and were conducted by trained survey researchers at the university's Institute for Public Policy and Social Research. Surveyors were blinded to the group assignment of the participants they were interviewing.

At the baseline interview, conducted between 1 and 4 weeks after discharge from the hospital (mean 14.11 9.6 days), patients answered questions of survey interviewers including demographic and background information, comorbid conditions (Charlson comorbidity index [CCI] method),21 history of depression, current depressive symptoms (Center for Epidemiological Studies‐Depression [CES‐D] tool)22, and tobacco use.

Smoking status at the time of hospitalization was established based on 2 sources of information: the medical record chart audits, and the baseline interview. The baseline interview asked Have you ever smoked tobacco? Respondents answering yes were asked: Do you smoke every day, some days, or not at all?; How many cigarettes do you now smoke per day on average?; and On average, when you smoked in the past 30 days, how many cigarettes did you smoke? Respondents who reported that they quit smoking were asked when they had quit. Comparing the time between the baseline interview and the original hospital admission, the research team could establish who quit by the time of the baseline interview, but had still been a smoker at the time of hospitalization. Therefore, this group of patients was considered smokers for the purpose of this study; defined as smoking at the time of hospitalization for this heart event. All other patients were treated as nonsmokers. Smoking status at hospitalization was then confirmed with the hospital medical record, which provided information on whether the patient was a current, ever, or never smoker, the years smoked, and the number of packs currently smoked per day.

In the subsequent 3‐month and 8‐month interviews, each patient's reported smoking status and frequency was reassessed through the items, Have there been any changes in your tobacco use in the past 3 months? and During the last month, have you smoked everyday, some days, or not at all? If the patient reported current smoking, then he/she was asked On the average, when you smoked during the past 30 days, about how many cigarettes did you smoke a day? If the patient reported quitting, he/she was asked How long ago did you quit smoking? Household smoking was assessed by the question In the past 30 days, has anyone, besides yourself, smoked cigarettes, cigars, or pipes anywhere inside your home?

Data Analysis

In addition to descriptive statistics characterizing the analysis sample, the analysis relies on multinomial logit regression models to predict who among the smoking ACS patients discharged would continue to smoke, would quit for the observation period, or would relapse.23, 24 Multinomial logit regression represents an extension of the more familiar binary logistic regression25 involving comparisons of all possible pairs of outcomes. Specifically, instead of employing separate logistic regression models to compare permanent quitters to continuing smokers, relapsers to continuing smoker, and permanent quitters to relapsers, these comparisons are contrasts in the multinomial model.

Thus, in addition to obtaining adjusted odds ratio (OR)s that take account of the simultaneous influence of all predictors, this analysis produces overall goodness‐of‐fit indicators and multivariate significance tests, which test whether coefficients associated with a particular independent variable have a simultaneous effect on the outcome across all categories. For instance, a multinomial P‐value of less than 0.05 for a subject's history of depression would indicate that such a history has a significant effect on whether or not subjects continue to smoke, quit for good, or relapse. The specific ORs and their associated significance levels then indicate if and to what degree prior depression affects each 2‐way contrast (quitters versus smokers, relapsers versus smokers, quitters versus relapsers). The analysis was conducted using the mlogit procedure of the STATA, 9.0 software package.26

RESULTS

Subjects

Of 719 consenting patients, 166 (23.1%) were initially assessed to be smokers based on their medical record documentation. Smoking status at hospitalization could not be verified and smoking status after hospitalization could not be determined for 15 patients who did not participate in any of the follow‐up interviews, therefore they were excluded. An additional 15 patients were excluded because of the lack of a second follow‐up interview, which would have allowed us to determine whether they quit smoking for at least 3 months or relapsed. Therefore, we include only the 136 cases with generally complete interview data in the current analysis. Table 1 depicts the demographic, medical, and smoking‐related characteristics of these patients.

Demographic and Clinical Characteristics of Smoking HARP Patients at Baseline Interview (Preintervention)
VariableNumber or Mean SDPercentage
  • NOTE: n = 136.

Age (years)53.32 9.52 
Gender  
Male8361
Female5339
White/nonwhite race  
White11282.4
Nonwhite/multiracial/other2417.6
Marital status  
Married8059.3
Divorced/separated/widowed5640.7
Work for pay or profit  
Yes7152.2
No6447.1
Missing10.7
Highest education  
High‐school diploma or less7958.1
Some college or more5741.9
Family income  
Less than $15,000 per year3626.5
$15,000 or more per year9066.2
No information107.4
Ejection fraction (EF)  
EF 35%1410.3
EF > 35%11080.9
Unmeasured128.8
Number of comorbid conditions1.79 1.81 
Number of persons living in household2.63 1.41 
Past diagnosis of depression  
Yes4029.4
No9670.6

Significant Predictors of Cessation and Relapse

Of the 136 smokers who were interviewed at baseline and completed the follow‐up surveys, 45 continued to smoke at baseline and at subsequent interviews in which they participated (33.1%) were defined as continuing smokers. Sixty‐five patients quit smoking (quitters) and remained nonsmokers for the time of observationat least 1 more interview wave or an additional 3 months (47.8% of respondents). Twenty‐six of the 136 (19.1%) were relapsers. They reported quitting smoking shortly after their hospitalization, but reported smoking again at either the 3‐month or 8‐month interview. Smoking again was defined as answering every day or some days to the question During the last month, have you smoked every day, some days, or not at all?).

Table 2 shows the cross‐tabulations and Table 3 shows the result from the multinominal regression analysis identifying significant predictors of quitting and relapsing as compared to continued smoking, relapsing versus quitting. Initially, the model included patient age (continuous variable), sex, years of education, race/ethnicity (other versus Caucasian) and insurance status (Medicare, Medicaid, employer‐based private insurance, other private insurance, no insurance) among the predictor variables, but they were eliminated from the model based on the nonsignificance of the likelihood ratio chi square test associated with each of them. In the final model, we retained only significant predictor variables, except for 1: membership in the study groups (intervention group with coaching, intervention group without coaching, control group). To ease interpretation, the table displays 3 columns of the adjusted ORs, comparing all 2‐way comparisons of outcomes. The third column, comparing relapsers and quitters, is technically redundant, as its ORs represent the ratios of the other 2 columns, but the values may be of interest to readers. The multinomial P‐values in the right‐hand column confirm that, with the sole exception of study group membership, every remaining independent variable is a significant predictor of smoking status after hospital discharge.

Cross‐Tabulations Comparing Smokers to Successful Quitters and Relapsers Among PostHospital Discharge Acute Coronary Syndrome Patients Who Smoked When They Entered the Hospital
Independent VariablesSmokers [n (%)]*Relapsers [n (%)]Quitters [n (%)]P‐Value
  • NOTE: n = 136; likelihood ratio 2 = 55.08; degrees of freedom = 14; P < 0.0001.

  • Smokers are defined as those who continued to smoke after the hospitalization.

  • Relapsers are defined as those who quit smoking after hospitalization but had begun smoking again by either the 3‐month or 8‐month interview.

  • Successful quitters are defined as those who quit smoking and remained quit for the observation period.

  • Significance tests associated with multiple category predictors.

Household income    
<$15,00021 (58)6 (17)9 (25) 
$15,000+22 (24)19 (21)59 (54)0.003
Study group    
QI only22 (37)13 (21)25 (42) 
QI‐plus HARP (coached)14 (27)10 (20)27 (53) 
QI‐plus HARP (not coached)9 (36)3 (12)13 (52)0.644
History of depression    
No30 (31)12 (13)54 (56) 
Yes14 (36)14 (36)11 (28)0.002
Smokers in household    
No19 (23)11 (14)51 (63) 
Yes26 (47)15 (27)14 (25)0.000
Intensity of smoking    
Moderate/heavy26 (29)13 (15)49 (56) 
Light19 (40)13 (27)16 (33)0.034
Multinomial Logistic Regression Comparing Smokers to Successful Quitters and Relapsers Among PostHospital Discharge Acute Coronary Syndrome Patients Who Smoked When They Entered the Hospital
Independent VariablesSuccessful Quitters* versus Smokers OR (95% CI)Relapsers versus Smokers OR (95% CI)Relapsers versus Successful Quitters* OR (95% CI)Multinomial P Value
  • NOTE: n = 136; likelihood ratio 2 = 55.08; degrees of freedom = 14; P < 0.0001; Bolded items indicate significant relationships.

  • Abbreviations: CI, confidence interval; OR, adjusted odds ratio.

  • Successful quitters are defined as those who quit smoking and remained quit for the observation period.

  • Smokers are defined as those who continued to smoke after the hospitalization.

  • Relapsers are defined as those who quit smoking after hospitalization but had begun smoking again by either the 3‐month or 8‐month interview.

  • Significance tests associated with multiple category predictors.

  • Reference category (comparison group in parentheses).

Household income ($15,000)   0.007
$15,000+4.72 (1.69‐12.87)3.38 (1.09‐9.97)1.72 (0.85‐3.46)0.005
Study group (intervention)   0.56
QI‐plus HARP (uncoached)0.86 (0.24‐3.05)0.46 (0.10‐2.65)0.53 (0.26‐1.09)0.65
QI only0.52 (0.19‐1.39)0.81 (0.28‐2.70)1.56 (0.85‐2.84)0.42
History of depression (yes)0.42 (0.16‐1.41)2.66 (1.02‐7.49)6.38 (2.34‐17.34)0.007
Smokers in household (yes)0.20 (0.08‐0.55)0.97 (0.32‐2.61)4.74 (1.57‐14.24)0.001
Intensity of smoking (moderate to heavy)    
Light0.20 (0.04‐0.99)1.29 (0.44‐3.56)0.16 (0.05‐0.57)0.08

As the data show, patients with higher household incomes have substantially higher odds of quitting than low‐income patients (OR = 4.72; P = 0.001); yet they also have greater odds of relapsing (OR = 3.38; P = 0.04). Patients with a history/past diagnosis of depression are not more likely to quit than those without a depression history; however, they have larger odds of relapsing back to smoking (ie, the OR for the comparison of relapsers versus smokers (OR = 2.66; P = 0.05) almost reaches the conventional significance level, while the OR for the contrast of relapsers versus quitters (OR = 6.38; P = 0.002) is significant and of substantial magnitude. By comparison, the presence of other smokers in a patient's household both lowers the odds of becoming a successful quitter (OR = 0.20; P = 0.001), and raises the odds of relapsing after initial quitting (OR = 4.74; P = 0.005). While lighter smokers (defined as <10 cigarettes a day) before hospitalization do not appear to be more successful in quitting than heavier smokers (defined as >20 cigarettes a day) (OR = 1.29; P = 0.62), they are less likely to relapse to smoking if they quit (OR = 0.16; P = 0.03).

Specific results relating to the telephone counseling intervention are found elsewhere.17, 18 However, we did include in Table 2 the specific results for the study groups to illustrate that the intervention program was not a factor predicting cessation. Analysis of the data using intention‐to‐treat (assuming all losses to follow‐up were continuing smokers) resulted in similar findings at the 8‐month follow‐up (2 = 2.635; degrees of freedom [df] = 2; P = 0.268).

DISCUSSION

The smoking cessation rate of 56.8% (n = 111; only those with 8‐month follow‐up) in this study population at 8 months compares favorably with the range of 31% to 60% shown in earlier studies of cardiac populations.610, 27 Assuming more conservatively that the survey nonresponders were all smokers yields a 46.3% quit rate (n = 136; all those with at least 1 follow‐up), which is within the range reported in the literature.

The intervention program was not a factor predicting cessation. Most posthospital follow‐up counseling is associated with increased smoking abstinence at follow‐up.28, 29 It is possible that the GAP in‐hospital QI initiative in these hospitals contributed to improving the cessation of smokers in both trial arms, thereby negating the effect of the counseling‐only option, although we did not specifically study the effect of the GAP intervention. It is also possible that we were underpowered to detect a statistically significant difference given our sample size of smokers.

Several characteristics were associated with successful smoking cessation in posthospitalized ACS patients. These included higher incomes, no other smokers in the household, and being a lighter smoker. We also found, however, that those with a history of depression, and heavier smokers also had higher rates of relapsing. As with previous research, our results support the evidence that heavier smokers have greater difficulty quitting smoking.6, 9, 14, 15 Heavier smoking indicates a greater nicotine addiction.27 However, 1 study of smoking cessation of smokers at a tertiary referral, cardiothoracic hospital found that smokers with greater pack years (eg, number of years smoked at an equivalent of 1 pack per day), had a higher likelihood of abstinence at a 12‐month follow‐up.30 More intense efforts are likely needed to assist smokers with a more significant addiction. Perhaps studies are needed to better understand the physiological and genetic mechanisms of nicotine addiction and effective treatment options for this group.

Our results also demonstrate that those with a history of depression were more likely to relapse. Several researchers have demonstrated that in patients with a history of depression, return of depressive symptoms upon a cessation attempt may precipitate relapse.28, 29 Current depressive symptoms, as measured by the CES‐D, were not associated with decreased rates of quitting or relapsing. After controlling for history of depression, the CES‐D score was no longer a predictor of quitting or relapsing in our data.

Similar to other studies, smokers in this study who reported having other smokers in the household had a more difficult time both quitting and remaining abstinent.16, 31 A related controversy concerns the efficacy of including (smoking and nonsmoking) family members in interventions to sustain longer‐term abstinence. Including family members has demonstrated efficacy in some research,3234 although the optimal means of involving family members in smoking cessation interventions has not yet been identified. Severity of cardiac disease (as measured by ejection fraction) and the presence of comorbid conditions were not found to be associated with smoking continuation or cessation. We did not find in this sample of ACS patients that smoking cessation rates increased with age during the follow‐up survey time points.

There are several limitations to our study. First, we did not biochemically validate self‐reported smoking cessation rates. However, it is generally found that self‐reports of cessation are accurate in research studies.35 Also participants may have incorrectly stated their quit rates due to recall bias. We were unable to fully capture use of smoking cessation pharmacotherapy (such as bupropion or nicotine replacement), which may have better explained success with cessation. Unfortunately, this is also not usually captured in the literature on studies of this nature. Last, since this study enrolled only cardiac patients in 2 similar community populations, these results may not be fully generalizable to other communities.

For smokers suffering from cardiac disease, there are few better ways to prevent a second heart event than quitting smoking. Judging from these results, there still remain a great number of hospitalized smokers who either choose to, or are unable to, successfully quit smoking, even after hospitalization for a serious cardiac event. Further research is needed to understand what individual motivating or household mechanisms may be best considered when encouraging this group of smokers to quit permanently.

Acknowledgements

Special thanks to Dr. Azfar Siddiqi for database management, Chrystal Price for data entry, and Camille Proden for chart abstraction and study recruitment. Supported by Agency for Health Research and Quality (AHRQ) grant number R01 HS 10531 (to M.H.‐R.).

References
  1. Mokdad AH,Marks JS,Stroup DF,Gerberding JL.Actual causes of death in the United States 2000.JAMA.2004;291(10):12381245.
  2. Goldstein MG,Niaura R.Methods to enhance smoking cessation after myocardial infarction.Med Clin North Am.2000;84(1):6380.
  3. Edwards R.The problem of tobacco smoking.BMJ.2004;328:217219.
  4. Wilhelmsen L.Effects of cessation of smoking after myocardial infarction.J Cardiovasc Risk.1998;5(3):173176.
  5. Wilson K,Gibson N,Willan A,Cook D.Effect of smoking cessation on mortality after myocardial infarction.Ann Intern Med.2000;160:939944.
  6. Attebring MF,Hartford M,Hjalmarson A,Caidahl K,Karlsson T,Herlitz J.Smoking habits and predictors of continued smoking in patients with acute coronary syndromes.JAdv Nurs.2004;46(6):614623.
  7. Hajek P,Taylor TZ,Mills P.Brief intervention during hospital admission to help patients to give up smoking after myocardial infarction and bypass surgery: randomised controlled trial.BMJ.2002;324(7329):8789.
  8. Pederson LL,Wanklin JM,Lefcoe NM.The effects of counseling on smoking cessation among patients hospitalized with chronic obstructive pulmonary disease: a randomized clinical trial.Int J Addict.1991;26(1):107119.
  9. Quist‐Paulsen P,Gallefoss F.Randomised controlled trial of smoking cessation intervention after admission for coronary heart disease.BMJ.2003;327(7426):12541257.
  10. van Berkel TF,Boersma H,De Baquer D,Deckers JW,Wood D.Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE Survey.Eur Heart J.1999;20(22):16301637.
  11. Mayou RA,Gill D,Thompson DR, et al.Depression and anxiety as predictors of outcome after myocardial infarction.Psychosom Med.2000;62(2):212219.
  12. Brummett BH,Babyak MA,Mark DC, et al.Predictors of smoking cessation in patients with a diagnosis of coronary artery disease.J Cardiopulm Rehabil.2002;22(3):143147.
  13. Huijbrechts IP,Duivenvoorden HJ,Deckers JW, et al.Modification of smoking habits five months after myocardial infarction: relationship with personality characteristics.J Psychosom Res.1996;40(4):369378.
  14. Hasdai D,Garratt KN,Grill DE, et al.Predictors of smoking cessation after percutaneous coronary revascularization.Mayo Clin Proc.1998;73(3):205209.
  15. Ong KC,Cheong GN,Prabhakaran L,Earnest A.Predictors of success in smoking cessation among hospitalized patients.Respirology.2005;10(1):6369.
  16. Chandola T,Head J,Bartley M.Socio‐demographic predictors of quitting smoking: how important are household factors.Addiction.2004;99(6):770777.
  17. Holtrop JS,Corser WD,Jones G,Brooks G,Holmes‐Rovner M,Stommel M.Health behavior goals of cardiac patients after hospitalization.Am J Health Behav.2006;30(4):387399.
  18. Holmes‐Rovner M,Stommel M,Corser WA, et al.Does outpatient telephone coaching add to hospital quality improvement following hospitalization for acute coronary syndrome?J Gen Intern Med.2008;23(9):14641470.
  19. Mehta R,Montoye C,Gallogly M, et al.Improving quality of care for acute myocardial infarction. The guidelines applied in practice (GAP) initiative.JAMA.2002;287(10):12691276.
  20. Mehta R,Montoye C,Gallogly M, et al.Improving quality of care for acute myocardial infarction.JAMA.2002;287(10):12691276.
  21. Charlson ME,Pompei P,Ales KL,MacKenzie CR.A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.J Chronic Dis.1987;40(5):373383.
  22. Devins G,Orme CM.Center for Epidemiologic Studies Depression Scale. In:Keyser DJ,Sweetland RC, eds.Test Critiques. Vol2.Kansas City, MO:Test Corporation;1985:144160.
  23. Agresti A.Categorical Data Analysis.New York, NY:Wiley 1990.
  24. Long JS.Regression Models for Categorical and Limited Dependent Variables.Thousand Oaks, CA:Sage;1997.
  25. Hosmer D,Lemeshow S.Applied Logistic Regression.New York, NY:John Wiley 1989.
  26. Stata Statistical Software: Release 9.College Station, TX:StataCorp LP;2005.
  27. van Berkel TF,Boersma H,De Baquer D,Deckers JW,Wood D.Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE Survey.Eur Heart J.1999;20(22):16301637.
  28. Rigotti NA,Munafo MR,Murphy MF,Stead LF.Interventions for smoking cessation in hospitalized patients.Cochrane Database Syst Rev.2003;(1):CD001837.
  29. France EK,Glasgow RE,Marcus AC.Smoking cessation interventions among hospitalized patients: what have we learned.Prev Med.2001;32(4):376388.
  30. Fung PR,Snape‐Jenkinson SL,Godfrey MT, et al.Effectiveness of hospital‐based smoking cessation.Chest.2005;128(1):216223.
  31. Miller CE,Ratner PA,Johnson JL.Reducing cardiovascular risk: identifying predictors of smoking relapse.Can J Cardiovasc Nurs.2003;13(3):712.
  32. Curry SJ,Hollis J,Bush T, et al.A randomized trial of a family‐based smoking prevention intervention in managed care.Prev Med.2003;37:617626.
  33. Park EW,Schultz JK,Tudiver F,Campbell T,Becker L.Enhancing partner support to improve smoking cessation.Cochrane Database Syst Rev.2004;(3):CD002928.
  34. Rohrbaugh MJ,Shoham V,Trost S,Muramoto M,Cate RM,Leischow S.Couple dynamics of change‐resistant smoking: toward a family consultation model.Fam Process.2001;40:115131.
  35. Caraballo RS,Giovino GA,Pechacek TF,Mowery PD.Factors associated with discrepancies between self‐reports on cigarette smoking and measured serum cotinine levels among persons aged 17 years or older: Third National Health and Nutrition Examination Survey, 1988–1994.Am J Epidemiol.2001;153(8):807814.
References
  1. Mokdad AH,Marks JS,Stroup DF,Gerberding JL.Actual causes of death in the United States 2000.JAMA.2004;291(10):12381245.
  2. Goldstein MG,Niaura R.Methods to enhance smoking cessation after myocardial infarction.Med Clin North Am.2000;84(1):6380.
  3. Edwards R.The problem of tobacco smoking.BMJ.2004;328:217219.
  4. Wilhelmsen L.Effects of cessation of smoking after myocardial infarction.J Cardiovasc Risk.1998;5(3):173176.
  5. Wilson K,Gibson N,Willan A,Cook D.Effect of smoking cessation on mortality after myocardial infarction.Ann Intern Med.2000;160:939944.
  6. Attebring MF,Hartford M,Hjalmarson A,Caidahl K,Karlsson T,Herlitz J.Smoking habits and predictors of continued smoking in patients with acute coronary syndromes.JAdv Nurs.2004;46(6):614623.
  7. Hajek P,Taylor TZ,Mills P.Brief intervention during hospital admission to help patients to give up smoking after myocardial infarction and bypass surgery: randomised controlled trial.BMJ.2002;324(7329):8789.
  8. Pederson LL,Wanklin JM,Lefcoe NM.The effects of counseling on smoking cessation among patients hospitalized with chronic obstructive pulmonary disease: a randomized clinical trial.Int J Addict.1991;26(1):107119.
  9. Quist‐Paulsen P,Gallefoss F.Randomised controlled trial of smoking cessation intervention after admission for coronary heart disease.BMJ.2003;327(7426):12541257.
  10. van Berkel TF,Boersma H,De Baquer D,Deckers JW,Wood D.Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE Survey.Eur Heart J.1999;20(22):16301637.
  11. Mayou RA,Gill D,Thompson DR, et al.Depression and anxiety as predictors of outcome after myocardial infarction.Psychosom Med.2000;62(2):212219.
  12. Brummett BH,Babyak MA,Mark DC, et al.Predictors of smoking cessation in patients with a diagnosis of coronary artery disease.J Cardiopulm Rehabil.2002;22(3):143147.
  13. Huijbrechts IP,Duivenvoorden HJ,Deckers JW, et al.Modification of smoking habits five months after myocardial infarction: relationship with personality characteristics.J Psychosom Res.1996;40(4):369378.
  14. Hasdai D,Garratt KN,Grill DE, et al.Predictors of smoking cessation after percutaneous coronary revascularization.Mayo Clin Proc.1998;73(3):205209.
  15. Ong KC,Cheong GN,Prabhakaran L,Earnest A.Predictors of success in smoking cessation among hospitalized patients.Respirology.2005;10(1):6369.
  16. Chandola T,Head J,Bartley M.Socio‐demographic predictors of quitting smoking: how important are household factors.Addiction.2004;99(6):770777.
  17. Holtrop JS,Corser WD,Jones G,Brooks G,Holmes‐Rovner M,Stommel M.Health behavior goals of cardiac patients after hospitalization.Am J Health Behav.2006;30(4):387399.
  18. Holmes‐Rovner M,Stommel M,Corser WA, et al.Does outpatient telephone coaching add to hospital quality improvement following hospitalization for acute coronary syndrome?J Gen Intern Med.2008;23(9):14641470.
  19. Mehta R,Montoye C,Gallogly M, et al.Improving quality of care for acute myocardial infarction. The guidelines applied in practice (GAP) initiative.JAMA.2002;287(10):12691276.
  20. Mehta R,Montoye C,Gallogly M, et al.Improving quality of care for acute myocardial infarction.JAMA.2002;287(10):12691276.
  21. Charlson ME,Pompei P,Ales KL,MacKenzie CR.A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.J Chronic Dis.1987;40(5):373383.
  22. Devins G,Orme CM.Center for Epidemiologic Studies Depression Scale. In:Keyser DJ,Sweetland RC, eds.Test Critiques. Vol2.Kansas City, MO:Test Corporation;1985:144160.
  23. Agresti A.Categorical Data Analysis.New York, NY:Wiley 1990.
  24. Long JS.Regression Models for Categorical and Limited Dependent Variables.Thousand Oaks, CA:Sage;1997.
  25. Hosmer D,Lemeshow S.Applied Logistic Regression.New York, NY:John Wiley 1989.
  26. Stata Statistical Software: Release 9.College Station, TX:StataCorp LP;2005.
  27. van Berkel TF,Boersma H,De Baquer D,Deckers JW,Wood D.Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE Survey.Eur Heart J.1999;20(22):16301637.
  28. Rigotti NA,Munafo MR,Murphy MF,Stead LF.Interventions for smoking cessation in hospitalized patients.Cochrane Database Syst Rev.2003;(1):CD001837.
  29. France EK,Glasgow RE,Marcus AC.Smoking cessation interventions among hospitalized patients: what have we learned.Prev Med.2001;32(4):376388.
  30. Fung PR,Snape‐Jenkinson SL,Godfrey MT, et al.Effectiveness of hospital‐based smoking cessation.Chest.2005;128(1):216223.
  31. Miller CE,Ratner PA,Johnson JL.Reducing cardiovascular risk: identifying predictors of smoking relapse.Can J Cardiovasc Nurs.2003;13(3):712.
  32. Curry SJ,Hollis J,Bush T, et al.A randomized trial of a family‐based smoking prevention intervention in managed care.Prev Med.2003;37:617626.
  33. Park EW,Schultz JK,Tudiver F,Campbell T,Becker L.Enhancing partner support to improve smoking cessation.Cochrane Database Syst Rev.2004;(3):CD002928.
  34. Rohrbaugh MJ,Shoham V,Trost S,Muramoto M,Cate RM,Leischow S.Couple dynamics of change‐resistant smoking: toward a family consultation model.Fam Process.2001;40:115131.
  35. Caraballo RS,Giovino GA,Pechacek TF,Mowery PD.Factors associated with discrepancies between self‐reports on cigarette smoking and measured serum cotinine levels among persons aged 17 years or older: Third National Health and Nutrition Examination Survey, 1988–1994.Am J Epidemiol.2001;153(8):807814.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
E3-E9
Page Number
E3-E9
Article Type
Display Headline
Predictors of smoking cessation and relapse after hospitalization for acute coronary syndrome
Display Headline
Predictors of smoking cessation and relapse after hospitalization for acute coronary syndrome
Legacy Keywords
heart disease, hospital inpatients, smoking cessation
Legacy Keywords
heart disease, hospital inpatients, smoking cessation
Sections
Article Source

Copyright © 2009 Society of Hospital Medicine

Disallow All Ads
Correspondence Location
Department of Family Medicine, Michigan State University, B105 Clinical Center, East Lansing, MI 48824
Content Gating
No Gating (article Unlocked/Free)
Alternative CME
Article PDF Media

Hospital Charges for Childhood Obesity

Article Type
Changed
Sun, 05/28/2017 - 21:52
Display Headline
Persistent gap of incremental charges for obesity as a secondary diagnosis in common pediatric hospitalizations

With increases in the prevalence of obesity among children and adults over the past 3 decades in the United States,13 healthcare expenditures attributed to obesity have climbed steadily, to over $100 billion in excess expenditures annually.4 Several studies have examined healthcare costs associated with obesity in adults,48 but these studies have not attempted to distinguish between excess expenditures in inpatient versus outpatient settings. In contrast, the only 2 national economic analyses of childhood obesity have focused exclusively on the inpatient setting, because the health and economic consequences of obesity among children may be most apparent in cases in which obesity is causally linked to other diagnoses (eg, type 2 diabetes mellitus, gall bladder disease) or is a comorbidity that complicates hospitalizations.9, 10

In our previous study of obesity as a comorbidity for hospitalized children, we examined the incremental charges and length‐of‐stay (LOS) for hospitalizations for the most common nonpregnancy/nonchildbirth pediatric diagnoses, comparing those coded with obesity as a secondary diagnosis versus those without.10 Using data from the Agency for Healthcare Research and Quality (AHRQ) Kid's Inpatient Database (KID) for the year 2000, we found that obesity was associated with higher charges and longer LOS for all 4 of the conditions studied (asthma, pneumonia, affective disorders, and appendicitis). Our findings regarding asthma and affective disorders echoed earlier analyses of hospitalizations for conditions clinically linked to obesity.9 However, our study was the first to demonstrate that childhood obesity is a clinically and economically significant complicating factor for conditions not thought to be linked to obesity (pneumonia, appendicitis).

For this current study, our objective was to use more recent child hospitalization data from 2003 to determine whether our prior findings of incremental charges and LOS associated with hospitalizations where obesity was coded as a secondary diagnosis compared to those where it was not, were stable over time, and whether the magnitude of differences was consistent over a period of 4 years. We hypothesized that incremental differences in hospital charges and LOS between discharges with and without obesity would be seen in the 2003 data and that the magnitude of these differences in 2003 would be similar to those in 2000. Because obesity prevalence among children increased from 2000 to 2003,11 we also hypothesized that there would be a corresponding increase in the proportion of hospitalizations with obesity as a comorbidity.

METHODS

Data Source and Sample

We analyzed data from the AHRQ KID. The KID is a nationally representative sample of annual pediatric hospital discharges. Analysis using the KID allows for improved estimates due to the discharges from community, nonrehabilitation hospitals.12 It provides data found in standard hospital discharge abstracts for more than 2 million pediatric discharges, including International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes, LOS, total hospital charges, and patient demographic information.12 Our original analysis (published in Obesity, July 2007)10 utilized data from the 2000 KID. For this analysis we utilized data from the 2003 KID (the most recent version available), and for comparison we converted the results from the 2000 study into 2003 dollars using the Consumer Price Index for Medical Care.

Using ICD‐9‐CM codes, the KID provides the principal diagnosis for each discharge, along with up to 14 secondary diagnoses. It also provides Clinical Classification Software (CCS) codes, a diagnostic categorization scheme that permits grouping of related conditions. ICD‐9‐CM codes are collapsed into a smaller number of categories that are sometimes more useful for presenting descriptive statistics than are individual ICD‐9‐CM codes or the much broader categories of Diagnosis Related Groups (DRGs). For example, all ICD‐9‐CM codes for specific types of pneumonia would be grouped together under 1 CCS code but would exclude other respiratory conditions such as pneumothorax which would generally be included in the respiratory condition DRG.12

The 2000 KID contained 2,516,833 unweighted discharges, representing 7,291,038 discharges in the population. In the 2003 KID, there were 2,984,129 unweighted discharges representing 7,409,162 discharges in the population. Our sample included all discharges for nonpregnancy‐related conditions, in children 2 years of age (due to the Centers for Disease Control definition for overweight based on body mass index [BMI] that starts at age 2 years)13, 14 to 18 years of age (2000 weighted n = 1,527,309; 2003 weighted n = 1,613,258); these numbers exclude discharges with obesity as a primary diagnosis.

Key Variables

Our outcome variables were LOS and total charges for each of the common nonpregnancy‐related principal discharge diagnoses studied. For the 2000 and 2003 KID, total charges included all hospital fees with the exception of professional fees.15

The main independent variable of interest was presence of obesity as a secondary diagnosis. Discharges were classified as either with or without obesity based on the presence of the ICD‐9‐CM code 278.0x as a secondary diagnosis (1 if yes, 0 if no). This code captures obesity unspecified (278.00), overweight (278.01), and morbid obesity (278.02). Of note, the distribution of these codes did not vary significantly between the 2 study years.

Other independent variables included sex, age (2‐5 years, 6‐10 years, 11‐14 years, and 15‐18 years), race/ethnicity (white, black, Hispanic, and other), region (Northeast, Midwest, South, and West), hospital type (based on classification by the National Association of Children's Hospitals and Related Institutions [NACHRI] as general hospital, children's unit in a general hospital, and children's hospital) and expected primary payer (Medicaid, private, and other). We chose independent variables due to their established association with our outcomes and for their patterns of association with childhood obesity.

We did not include LOS as a covariate in models of charges because obesity may have been associated with the outcome indirectly through LOS as well as directly as a main effect. To fully interpret the combination of these effects would require analyses beyond the scope of this work.

Analyses

Using CCS codes, we identified the 4 most common principal nonpregnancy‐related discharge diagnoses for children 2‐18 years old. For both 2000 and 2003 these were asthma (CCS 128), pneumonia (CCS 122), affective disorders (eg, depression and bipolar disorder) (CCS 69), and appendicitis (CCS 142). Importantly, this group of diagnoses included conditions clinically associated with obesity (asthma and affective disorders)16 and conditions not associated with obesity (pneumonia and appendicitis). Given this distinction we analyzed the 4 conditions separately.

For all discharges with these common principal diagnoses, we calculated mean LOS and mean total charges. Bivariate and multivariable analyses were conducted using simple and multiple linear regression, respectively. These analyses were designed to test the study hypothesis that obesity as a secondary diagnosis is associated with incremental economic charges and LOS. All analyses were performed on log‐transformed LOS and charge data. We included in our models those characteristics that we hypothesized were potentially related to hospital charges and LOS, based on published literature,4, 17, 18 and for that reason all covariates were retained in the final models regardless of bivariate findings. Differences in the incremental LOS and charges for 2003 versus 2000 were compared using t‐tests.

For each independent variable with missing data, we included in the analyses a category for unreported values. The KID is known to have a large number of missing data for race/ethnicity; therefore, in keeping with other studies utilizing the KID,10, 19 we also conducted multivariate analyses excluding those discharges with unreported race as a sensitivity analysis. Of note, analyses of these data excluding children of unreported race were not substantively different than those in which the unreported group was included. We present our findings including the unreported race category.

Predicted values on the log scale, for those with obesity and without obesity as a secondary diagnosis adjusted for the listed covariates, were obtained. We then back‐transformed these to their original scales and units using methods developed by Duan.20 For each principal diagnosis category, we analyzed the differences in predicted mean LOS and predicted mean total charges between discharges with and without obesity as a secondary diagnosis, adjusted for the listed covariates, using the P values obtained from the regression analyses. All results are presented in 2003 dollars.

In keeping with our earlier analysis we considered the potential influence of comorbidities other than obesity on LOS and charges. Therefore, we examined whether other comorbidities were coded more frequently among those discharges with obesity as a secondary diagnosis than those discharges without obesity. As seen in the 2000 KID, the 2003 data revealed that diabetes was more commonly seen with obesity‐related hospitalizations than with those hospitalizations without obesity. However, the proportion of discharges with obesity and diabetes was low for all of the principal diagnostic categories studied (asthma 4.8%, pneumonia 6.0%, affective disorders 4.2%, and appendicitis 1.9%). Thus, we judged the co‐occurrence of diabetes and obesity as secondary diagnoses too infrequent to be an explanatory factor for the overall incremental differences in LOS and charges.

All analyses were weighted to account for the complex probability sampling of the dataset and permit inferences regarding national hospital discharge patterns. The same sample of discharges was used to analyze LOS and charges, with the discharge weighting variable (DISCWT) used for all analyses. All results are presented as weighted data unless otherwise noted. Analyses were conducted using STATA 8.0 (Stata Corporation, College Station, TX) and SUDAAN version 9 (Research Triangle Institute, Research Triangle Park, NC).

This study was approved by the Institutional Review Board of the University of Michigan Medical School.

RESULTS

Sample Characteristics

The characteristics of the study population are presented in Table 1. In 2003, the overall proportion of nonpregnancy‐related discharges for children 2‐18 years old coded with obesity as a secondary diagnosis was 1.6%, an increase from 1.1% in 2000. Within the 4 most common nonpregnancy‐related CCS category diagnoses (asthma, pneumonia, affective disorders, and appendicitis) the proportion of discharges with obesity coded as a secondary diagnosis increased from 2000 to 2003 (Figure 1)

Figure 1
Proportion of discharges with obesity coded as a secondary diagnosis for 2000 and 2003.
Characteristics of the Study Subpopulation from the 2000 and 2003 KID
VariablesDischarges
With Obesity as Secondary DiagnosisWithout Obesity
2000200320002003
Unweighted, n8,69615,546762,407943,182
Weighted population size17,67225,7091,509,6371,587,549
Age    
2‐5 years (%)4.84.827.429.0
6‐10 years (%)14.715.922.422.3
11‐14 years (%)34.434.120.920.9
15‐18 years (%)46.145.229.327.8
Sex    
Male (%)45.546.853.853.4
Race/Ethnicity    
White (%)46.832.250.939.3
Black (%)20.720.414.312.6
Hispanic (%)14.916.814.314.4
Other (%)4.85.05.65.6
Unreported (%)12.825.614.928.1
Payer    
Medicaid (%)42.646.532.136.9
Private (%)47.142.658.053.3
Other (%)9.410.69.49.6
Unreported (%)0.90.30.50.2
Hospital Region    
Northeast (%)17.315.921.718.7
Midwest (%)24.624.820.023.3
South (%)37.638.436.337.0
West (%)20.520.922.021.0
Hospital type    
General hospital (%)68.261.461.057.1
Children's unit in general hospital (%)15.217.818.619.2
Children's hospitals (%)14.314.917.917.6
Unreported (%)2.3%5.92.56.1

Incremental Differences in Mean Charges Associated with Obesity

In Table 2, we present results for analyses of mean charges. Following the pattern in 2000 for all 4 of these common conditions, in 2003 the adjusted mean total hospital charges were statistically significantly higher for discharges in which obesity was listed as a secondary diagnosis, compared with those in which it was not. Moreover, the magnitude of these differences was somewhat greater in 2003 than in 2000, although it did not achieve statistical significance (P > 0.05) (Figure 2). Specifically, the difference in charges among asthma discharges with and without obesity as a comorbidity was 9% greater in 2003 than in 2000, 17% greater among pneumonia discharges, 121% greater among affective disorders, and 3% greater among appendicitis discharges.

Figure 2
Differences in adjusted mean charges for discharges coded with and without obesity as a secondary diagnosis.
Adjusted Mean Charges for Discharges Coded with and Without Obesity as a Secondary Diagnosis in 2000 and 2003
 Adjusted Mean Charges ($)
20002003
With ObesityWithout ObesityDifferenceWith ObesityWithout ObesityDifference
  • NOTE: Values are given in 2003 dollars. All models adjusted for sex, age, race/ethnicity, region, hospital type, and expected primary payer.

  • <0.05.

  • <0.01.

Asthma8,8476,8841,963*10,5898,4442,145
Pneumonia13,93011,0362,894*16,60913,2193,390
Affective disorders9,4468,85059611,94210,6191,323
Appendicitis16,10112,5873,51419,21315,5863,627

Incremental Differences in Mean LOS Associated with Obesity

Compared with those discharges without obesity coded, obesity as a secondary diagnosis was associated with a statistically significantly longer mean LOS for all four diagnoses in 2003 (Table 3). In addition, for all diagnoses except asthma, the magnitude of the difference was somewhat greater in 2003 than in 2000, although it did not reach statistical significance (P > 0.05). The greatest increase was seen with appendicitis, with the incremental difference in LOS between those with obesity and those without going from 0.17 days in 2000 to 0.83 days in 2003; an increase of over 300%.

Adjusted Mean LOS for Discharges Coded with and Without Obesity as a Secondary Diagnosis in 2000 and 2003
 Adjusted Mean LOS
20002003
With ObesityWithout ObesityDifferenceWith ObesityWithout ObesityDifference
  • NOTE: All models adjusted for sex, age, race/ethnicity, region, hospital type, and expected primary payer.

  • <0.01.

  • <0.05.

Asthma3.042.450.59*2.882.440.44*
Pneumonia4.263.890.374.393.830.56
Affective disorders7.727.110.61*8.237.420.81*
Appendicitis3.333.160.173.913.080.83*

DISCUSSION

Prior studies have explored the resource utilization and expenditures associated with obesity in adult populations and among obese children in the outpatient setting.48, 21 Few, however, have examined charges related to inpatient care of obese children. Our studies are the first to utilize actual charge data from a nationally representative sample to explore the economic implications of obesity among children hospitalized for common pediatric illnesses.

Our findings from this national analysis support the hypothesis that, for the 4 conditions studied, statistically significantly higher mean total hospital charges and longer mean LOS for those discharges with obesity coded as a secondary diagnosis versus those without obesity coded occurred for both 2000 and 2003, even when controlling for sex, age, race/ethnicity, region, payer, and hospital type. Our analyses also suggested that the magnitude of the incremental differences in charges from 2000 to 2003 increased somewhat, and the magnitude of the incremental differences in LOS for all of these common conditions (except asthma) is also increasing.

While these findings serve to confirm higher incremental charges and LOS associated with obesity for hospitalized children, they raise the question of why charges and LOS for children with obesity might increase at a greater rate than for those without obesity. Higher hospital charges and LOS for children with obesity coded as a secondary diagnosis may be explained by greater resource utilization due to obesity that: 1) increases the technical complexity of procedures such as surgical interventions or intravenous catheter (IV) placement;22 2) leads to greater illness severity, as has been suggested in studies of adult patients;23, 24 or 3) leads to more complications such as secondary infections.22 One explanation for the possible widening of the gap in charges during the time period studied might be that discharges coded with obesity in 2003 reflect children who were more severely obese and had a greater severity of illness, leading to higher resource utilization than those with obesity in the 2000 dataset. However, the ICD‐9‐CM code for morbid obesity (278.02) was not used more often in 2003 than in 2000. Alternatively, we suspect that between 2000 and 2003, due to an increasing awareness of the problem of childhood obesity, physicians may have become more likely to order tests or consultations specifically related to the treatment or evaluation of obesity. Other than the increase in the proportion of discharges with obesity as a comorbidity from 2000 to 2003, we were unable to explore these possible explanations with the KID datasets.

In this sample of discharges, with only 1.1% and 1.6% coded with obesity as a secondary diagnosis in 2000 and 2003, respectively, it is important to note that these discharges should not be interpreted as the prevalence of obesity in hospitalized children. Indeed, in a recent study of children hospitalized for surgical procedures at a large Midwestern tertiary care hospital, 31.6% were found to be overweight or obese.25 However, we posit that the cases coded with obesity as a secondary diagnosis in this sample represent the cases in which obesity presents a recognized factor that complicated the clinical course. Further work should explore the mechanisms by which obesity impacts the care of children hospitalized for common conditions. For example, children with obesity may require more procedures and may experience more treatment complications. These specific interventions should be the target of clinically focused analyses.

Limitations

Analyses utilizing discharge data are potentially limited by the accuracy and consistency of coding. Whether the discharges coded with obesity reflect all cases in which obesity was a complicating factor is not known. Based on the national prevalence of childhood obesity it is likely than more than 1.6% of the children hospitalized in 2003 were obese. However, whether obesity impacted the hospital course sufficiently to be included among the secondary diagnoses (as stipulated by ICD‐9‐CM guidelines for official recording)26 in more than 1.6% of cases is unknown.

This study is also limited by the inability to address the processes that might account for the consistently higher charges and longer LOS seen for those discharges coded with obesity versus those without obesity coded. The KID provides some information regarding procedures performed but cannot be reliably used to examine this aspect of patient care.27 An additional limitation of the KID data set is that it contains information about deidentified discharges. This leads to the possibility of having individual patients in the dataset with multiple hospitalizations. In this study we examined the relationship between obesity as a secondary diagnosis and incremental charges and LOS for the 4 most common clinical categories for which children are hospitalized. Findings may differ for other conditions not evaluated here. Finally, information regarding costs can only be inferred from the charge data provided by the KID. However, the ratio of charges to costs would not be expected to vary by obesity status.

CONCLUSIONS

These results extend our earlier findings of higher charges and longer LOS for pediatric discharges coded with obesity versus those without. In addition, this analysis suggests a widening gap of incremental hospital charges and LOS associated with obesity as a comorbidity for common pediatric conditions. These findings present a heightening financial imperative for further research to evaluate factors associated with greater resource utilization among obese pediatric patients.

Files
References
  1. Ogden CL,Flegal KM,Carroll MD,Johnson CL.Prevalence and trends in overweight among US children and adolescents, 1999–2000.JAMA.2002;288(14):17281732.
  2. Strauss RS,Pollack HA.Epidemic increase in childhood overweight, 1986–1998.JAMA.2001;286(22):28452848.
  3. Troiano RP,Flegal KM.Overweight children and adolescents: description, epidemiology, and demographics.Pediatrics.1998;101(Pt 2):497504.
  4. Finkelstein EA,Fiebelkorn IC,Wang G.National medical spending attributable to overweight and obesity: how much, and who's paying?Health Aff (Millwood).2003; (Suppl Web Exclusives):W3‐21926.
  5. Thorpe KE,Florence CS,Howard DH,Joski P.The impact of obesity on rising medical spending.Health Aff (Millwood).2004;(Suppl Web Exclusives):W4‐4806.
  6. Wolf AM,Colditz GA.Current estimates of the economic cost of obesity in the United States.Obes Res.1998;6(2):97106.
  7. Oster G,Thompson D,Edelsberg J,Bird AP,Colditz GA.Lifetime health and economic benefits of weight loss among obese persons.Am J Public Health.1999;89(10):15361542.
  8. Lakdawalla DN,Goldman DP,Shang B.The health and cost consequences of obesity among the future elderly.Health Aff (Millwood).2005;24(Suppl 2):W5R30W5R41.
  9. Wang G,Dietz WH.Economic burden of obesity in youths aged 6 to 17 years: 1979–1999.Pediatrics.2002;109(5):E81E81.
  10. Woolford SJ,Gebremariam A,Clark SJ,Davis MM.Incremental hospital charges associated with obesity as a secondary diagnosis.Obesity (Silver Spring).2007;15:18951901.
  11. Ogden CL,Carroll MD,Curtin LR,McDowell MA,Tabak CJ,Flegal KM.Prevalence of overweight and obesity in the United States, 1999–2004.JAMA.2006;295(13):15491555.
  12. Healthcare Cost and Utilization Project.2005. Overview of the Kid's Inpatient Database. Available at:http://www.hcup‐us.ahrq.gov/kidoverview.jsp. Accessed December 2008.
  13. CDC Body Mass Index: BMI for Children and Teens. Available at: http://www.cdc.gov/nccdphp/dnpa/bmi. Accessed December2008.
  14. Ogden CL,Troiano RP,Briefel RR,Kuczmarski RJ,Flegal KM,Johnson CL.Prevalence of overweight among preschool children in the United States, 1971 through 1994.Pediatrics.1997;99(4):E1.
  15. Healthcare Cost and Utilization Project, 2002 and 2004. Description of data elements: inpatient core file. Available at: http://www.hcup‐us.ahrq.gov/db/nation/kid/DataElements_KID_Core_2000.pdf; http://www.hcup‐us.ahrq.gov/db/nation/kid/KID_2003_CORE_Volume1_A‐L.pdf;http://www.hcup‐us. ahrq.gov/db/nation/kid/KID_2003_CORE_Volume2_M‐Z.pdf. Accessed December2008.
  16. Dietz WH.Health consequences of obesity in youth: childhood predictors of adult disease.Pediatrics.1998;101:518525.
  17. Merenstein D,Egleston B,Diener‐West M.Lengths of stay and costs associated with children's hospitals.Pediatrics.2005;115(4):839844.
  18. Wee CC,Phillips RS,Legedza AT, et al.Health care expenditures associated with overweight and obesity among US adults: importance of age and race.Am J Public Health.2005;95(1):159165.
  19. Smink DS,Fishman SJ,Kleinman K,Finkelstein JA.Effects of race, insurance status, and hospital volume on perforated appendicitis in children.Pediatrics.2005;115(4):920925.
  20. Duan N.Smearing estimate: a nonparametric retransformation method.J Am Stat Assoc.1983;78:605610.
  21. Hampl SE,Carroll CA,Simon SD,Sharma V.Resource utilization and expenditures for overweight and obese children.Arch Pediatr Adolesc Med.2007 Jan;161(1):1114.
  22. Davies DA,Yanchar NL.Appendicitis in the obese child.J Pediatr Surg.2007;42(5):857861.
  23. Varon J,Marik P.Management of the obese critically ill patient.Crit Care Clin.2001;17:187200.
  24. Pelosi P,Croci M,Ravagnan I,Vicardi P,Gattinoni L.Total respiratory system, lung, and chest wall mechanics in sedated‐paralyzed postoperative morbidly obese patients.Chest.1996;109:144151.
  25. Nafiu OO,Ndao‐Brumlay KS,Bamgbade OA,Morris M,Kasa‐Vubu JZ.Prevalence of overweight and obesity in a U.S. pediatric surgical population.J Natl Med Assoc.2007;99(1):4648, 50–51.
  26. Centers for Disease Control and Prevention. ICD‐9‐CM. Official Guidelines for Coding and Reporting. Effective April 1, 2005. Available at: http://www.cdc.gov/nchs/data/icd9/icdguide.pdf. Accessed December2008.
  27. Gupta RS,Meenakshi B,Prosser LA,Finkelstein JA.Predictors of hospital charges for children admitted with asthma.Ambul Pediatr.2006;6(1):1520.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
149-156
Legacy Keywords
charges, comorbidity, economics, hospitalization, obesity, pediatrics, secondary diagnosis
Sections
Files
Files
Article PDF
Article PDF

With increases in the prevalence of obesity among children and adults over the past 3 decades in the United States,13 healthcare expenditures attributed to obesity have climbed steadily, to over $100 billion in excess expenditures annually.4 Several studies have examined healthcare costs associated with obesity in adults,48 but these studies have not attempted to distinguish between excess expenditures in inpatient versus outpatient settings. In contrast, the only 2 national economic analyses of childhood obesity have focused exclusively on the inpatient setting, because the health and economic consequences of obesity among children may be most apparent in cases in which obesity is causally linked to other diagnoses (eg, type 2 diabetes mellitus, gall bladder disease) or is a comorbidity that complicates hospitalizations.9, 10

In our previous study of obesity as a comorbidity for hospitalized children, we examined the incremental charges and length‐of‐stay (LOS) for hospitalizations for the most common nonpregnancy/nonchildbirth pediatric diagnoses, comparing those coded with obesity as a secondary diagnosis versus those without.10 Using data from the Agency for Healthcare Research and Quality (AHRQ) Kid's Inpatient Database (KID) for the year 2000, we found that obesity was associated with higher charges and longer LOS for all 4 of the conditions studied (asthma, pneumonia, affective disorders, and appendicitis). Our findings regarding asthma and affective disorders echoed earlier analyses of hospitalizations for conditions clinically linked to obesity.9 However, our study was the first to demonstrate that childhood obesity is a clinically and economically significant complicating factor for conditions not thought to be linked to obesity (pneumonia, appendicitis).

For this current study, our objective was to use more recent child hospitalization data from 2003 to determine whether our prior findings of incremental charges and LOS associated with hospitalizations where obesity was coded as a secondary diagnosis compared to those where it was not, were stable over time, and whether the magnitude of differences was consistent over a period of 4 years. We hypothesized that incremental differences in hospital charges and LOS between discharges with and without obesity would be seen in the 2003 data and that the magnitude of these differences in 2003 would be similar to those in 2000. Because obesity prevalence among children increased from 2000 to 2003,11 we also hypothesized that there would be a corresponding increase in the proportion of hospitalizations with obesity as a comorbidity.

METHODS

Data Source and Sample

We analyzed data from the AHRQ KID. The KID is a nationally representative sample of annual pediatric hospital discharges. Analysis using the KID allows for improved estimates due to the discharges from community, nonrehabilitation hospitals.12 It provides data found in standard hospital discharge abstracts for more than 2 million pediatric discharges, including International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes, LOS, total hospital charges, and patient demographic information.12 Our original analysis (published in Obesity, July 2007)10 utilized data from the 2000 KID. For this analysis we utilized data from the 2003 KID (the most recent version available), and for comparison we converted the results from the 2000 study into 2003 dollars using the Consumer Price Index for Medical Care.

Using ICD‐9‐CM codes, the KID provides the principal diagnosis for each discharge, along with up to 14 secondary diagnoses. It also provides Clinical Classification Software (CCS) codes, a diagnostic categorization scheme that permits grouping of related conditions. ICD‐9‐CM codes are collapsed into a smaller number of categories that are sometimes more useful for presenting descriptive statistics than are individual ICD‐9‐CM codes or the much broader categories of Diagnosis Related Groups (DRGs). For example, all ICD‐9‐CM codes for specific types of pneumonia would be grouped together under 1 CCS code but would exclude other respiratory conditions such as pneumothorax which would generally be included in the respiratory condition DRG.12

The 2000 KID contained 2,516,833 unweighted discharges, representing 7,291,038 discharges in the population. In the 2003 KID, there were 2,984,129 unweighted discharges representing 7,409,162 discharges in the population. Our sample included all discharges for nonpregnancy‐related conditions, in children 2 years of age (due to the Centers for Disease Control definition for overweight based on body mass index [BMI] that starts at age 2 years)13, 14 to 18 years of age (2000 weighted n = 1,527,309; 2003 weighted n = 1,613,258); these numbers exclude discharges with obesity as a primary diagnosis.

Key Variables

Our outcome variables were LOS and total charges for each of the common nonpregnancy‐related principal discharge diagnoses studied. For the 2000 and 2003 KID, total charges included all hospital fees with the exception of professional fees.15

The main independent variable of interest was presence of obesity as a secondary diagnosis. Discharges were classified as either with or without obesity based on the presence of the ICD‐9‐CM code 278.0x as a secondary diagnosis (1 if yes, 0 if no). This code captures obesity unspecified (278.00), overweight (278.01), and morbid obesity (278.02). Of note, the distribution of these codes did not vary significantly between the 2 study years.

Other independent variables included sex, age (2‐5 years, 6‐10 years, 11‐14 years, and 15‐18 years), race/ethnicity (white, black, Hispanic, and other), region (Northeast, Midwest, South, and West), hospital type (based on classification by the National Association of Children's Hospitals and Related Institutions [NACHRI] as general hospital, children's unit in a general hospital, and children's hospital) and expected primary payer (Medicaid, private, and other). We chose independent variables due to their established association with our outcomes and for their patterns of association with childhood obesity.

We did not include LOS as a covariate in models of charges because obesity may have been associated with the outcome indirectly through LOS as well as directly as a main effect. To fully interpret the combination of these effects would require analyses beyond the scope of this work.

Analyses

Using CCS codes, we identified the 4 most common principal nonpregnancy‐related discharge diagnoses for children 2‐18 years old. For both 2000 and 2003 these were asthma (CCS 128), pneumonia (CCS 122), affective disorders (eg, depression and bipolar disorder) (CCS 69), and appendicitis (CCS 142). Importantly, this group of diagnoses included conditions clinically associated with obesity (asthma and affective disorders)16 and conditions not associated with obesity (pneumonia and appendicitis). Given this distinction we analyzed the 4 conditions separately.

For all discharges with these common principal diagnoses, we calculated mean LOS and mean total charges. Bivariate and multivariable analyses were conducted using simple and multiple linear regression, respectively. These analyses were designed to test the study hypothesis that obesity as a secondary diagnosis is associated with incremental economic charges and LOS. All analyses were performed on log‐transformed LOS and charge data. We included in our models those characteristics that we hypothesized were potentially related to hospital charges and LOS, based on published literature,4, 17, 18 and for that reason all covariates were retained in the final models regardless of bivariate findings. Differences in the incremental LOS and charges for 2003 versus 2000 were compared using t‐tests.

For each independent variable with missing data, we included in the analyses a category for unreported values. The KID is known to have a large number of missing data for race/ethnicity; therefore, in keeping with other studies utilizing the KID,10, 19 we also conducted multivariate analyses excluding those discharges with unreported race as a sensitivity analysis. Of note, analyses of these data excluding children of unreported race were not substantively different than those in which the unreported group was included. We present our findings including the unreported race category.

Predicted values on the log scale, for those with obesity and without obesity as a secondary diagnosis adjusted for the listed covariates, were obtained. We then back‐transformed these to their original scales and units using methods developed by Duan.20 For each principal diagnosis category, we analyzed the differences in predicted mean LOS and predicted mean total charges between discharges with and without obesity as a secondary diagnosis, adjusted for the listed covariates, using the P values obtained from the regression analyses. All results are presented in 2003 dollars.

In keeping with our earlier analysis we considered the potential influence of comorbidities other than obesity on LOS and charges. Therefore, we examined whether other comorbidities were coded more frequently among those discharges with obesity as a secondary diagnosis than those discharges without obesity. As seen in the 2000 KID, the 2003 data revealed that diabetes was more commonly seen with obesity‐related hospitalizations than with those hospitalizations without obesity. However, the proportion of discharges with obesity and diabetes was low for all of the principal diagnostic categories studied (asthma 4.8%, pneumonia 6.0%, affective disorders 4.2%, and appendicitis 1.9%). Thus, we judged the co‐occurrence of diabetes and obesity as secondary diagnoses too infrequent to be an explanatory factor for the overall incremental differences in LOS and charges.

All analyses were weighted to account for the complex probability sampling of the dataset and permit inferences regarding national hospital discharge patterns. The same sample of discharges was used to analyze LOS and charges, with the discharge weighting variable (DISCWT) used for all analyses. All results are presented as weighted data unless otherwise noted. Analyses were conducted using STATA 8.0 (Stata Corporation, College Station, TX) and SUDAAN version 9 (Research Triangle Institute, Research Triangle Park, NC).

This study was approved by the Institutional Review Board of the University of Michigan Medical School.

RESULTS

Sample Characteristics

The characteristics of the study population are presented in Table 1. In 2003, the overall proportion of nonpregnancy‐related discharges for children 2‐18 years old coded with obesity as a secondary diagnosis was 1.6%, an increase from 1.1% in 2000. Within the 4 most common nonpregnancy‐related CCS category diagnoses (asthma, pneumonia, affective disorders, and appendicitis) the proportion of discharges with obesity coded as a secondary diagnosis increased from 2000 to 2003 (Figure 1)

Figure 1
Proportion of discharges with obesity coded as a secondary diagnosis for 2000 and 2003.
Characteristics of the Study Subpopulation from the 2000 and 2003 KID
VariablesDischarges
With Obesity as Secondary DiagnosisWithout Obesity
2000200320002003
Unweighted, n8,69615,546762,407943,182
Weighted population size17,67225,7091,509,6371,587,549
Age    
2‐5 years (%)4.84.827.429.0
6‐10 years (%)14.715.922.422.3
11‐14 years (%)34.434.120.920.9
15‐18 years (%)46.145.229.327.8
Sex    
Male (%)45.546.853.853.4
Race/Ethnicity    
White (%)46.832.250.939.3
Black (%)20.720.414.312.6
Hispanic (%)14.916.814.314.4
Other (%)4.85.05.65.6
Unreported (%)12.825.614.928.1
Payer    
Medicaid (%)42.646.532.136.9
Private (%)47.142.658.053.3
Other (%)9.410.69.49.6
Unreported (%)0.90.30.50.2
Hospital Region    
Northeast (%)17.315.921.718.7
Midwest (%)24.624.820.023.3
South (%)37.638.436.337.0
West (%)20.520.922.021.0
Hospital type    
General hospital (%)68.261.461.057.1
Children's unit in general hospital (%)15.217.818.619.2
Children's hospitals (%)14.314.917.917.6
Unreported (%)2.3%5.92.56.1

Incremental Differences in Mean Charges Associated with Obesity

In Table 2, we present results for analyses of mean charges. Following the pattern in 2000 for all 4 of these common conditions, in 2003 the adjusted mean total hospital charges were statistically significantly higher for discharges in which obesity was listed as a secondary diagnosis, compared with those in which it was not. Moreover, the magnitude of these differences was somewhat greater in 2003 than in 2000, although it did not achieve statistical significance (P > 0.05) (Figure 2). Specifically, the difference in charges among asthma discharges with and without obesity as a comorbidity was 9% greater in 2003 than in 2000, 17% greater among pneumonia discharges, 121% greater among affective disorders, and 3% greater among appendicitis discharges.

Figure 2
Differences in adjusted mean charges for discharges coded with and without obesity as a secondary diagnosis.
Adjusted Mean Charges for Discharges Coded with and Without Obesity as a Secondary Diagnosis in 2000 and 2003
 Adjusted Mean Charges ($)
20002003
With ObesityWithout ObesityDifferenceWith ObesityWithout ObesityDifference
  • NOTE: Values are given in 2003 dollars. All models adjusted for sex, age, race/ethnicity, region, hospital type, and expected primary payer.

  • <0.05.

  • <0.01.

Asthma8,8476,8841,963*10,5898,4442,145
Pneumonia13,93011,0362,894*16,60913,2193,390
Affective disorders9,4468,85059611,94210,6191,323
Appendicitis16,10112,5873,51419,21315,5863,627

Incremental Differences in Mean LOS Associated with Obesity

Compared with those discharges without obesity coded, obesity as a secondary diagnosis was associated with a statistically significantly longer mean LOS for all four diagnoses in 2003 (Table 3). In addition, for all diagnoses except asthma, the magnitude of the difference was somewhat greater in 2003 than in 2000, although it did not reach statistical significance (P > 0.05). The greatest increase was seen with appendicitis, with the incremental difference in LOS between those with obesity and those without going from 0.17 days in 2000 to 0.83 days in 2003; an increase of over 300%.

Adjusted Mean LOS for Discharges Coded with and Without Obesity as a Secondary Diagnosis in 2000 and 2003
 Adjusted Mean LOS
20002003
With ObesityWithout ObesityDifferenceWith ObesityWithout ObesityDifference
  • NOTE: All models adjusted for sex, age, race/ethnicity, region, hospital type, and expected primary payer.

  • <0.01.

  • <0.05.

Asthma3.042.450.59*2.882.440.44*
Pneumonia4.263.890.374.393.830.56
Affective disorders7.727.110.61*8.237.420.81*
Appendicitis3.333.160.173.913.080.83*

DISCUSSION

Prior studies have explored the resource utilization and expenditures associated with obesity in adult populations and among obese children in the outpatient setting.48, 21 Few, however, have examined charges related to inpatient care of obese children. Our studies are the first to utilize actual charge data from a nationally representative sample to explore the economic implications of obesity among children hospitalized for common pediatric illnesses.

Our findings from this national analysis support the hypothesis that, for the 4 conditions studied, statistically significantly higher mean total hospital charges and longer mean LOS for those discharges with obesity coded as a secondary diagnosis versus those without obesity coded occurred for both 2000 and 2003, even when controlling for sex, age, race/ethnicity, region, payer, and hospital type. Our analyses also suggested that the magnitude of the incremental differences in charges from 2000 to 2003 increased somewhat, and the magnitude of the incremental differences in LOS for all of these common conditions (except asthma) is also increasing.

While these findings serve to confirm higher incremental charges and LOS associated with obesity for hospitalized children, they raise the question of why charges and LOS for children with obesity might increase at a greater rate than for those without obesity. Higher hospital charges and LOS for children with obesity coded as a secondary diagnosis may be explained by greater resource utilization due to obesity that: 1) increases the technical complexity of procedures such as surgical interventions or intravenous catheter (IV) placement;22 2) leads to greater illness severity, as has been suggested in studies of adult patients;23, 24 or 3) leads to more complications such as secondary infections.22 One explanation for the possible widening of the gap in charges during the time period studied might be that discharges coded with obesity in 2003 reflect children who were more severely obese and had a greater severity of illness, leading to higher resource utilization than those with obesity in the 2000 dataset. However, the ICD‐9‐CM code for morbid obesity (278.02) was not used more often in 2003 than in 2000. Alternatively, we suspect that between 2000 and 2003, due to an increasing awareness of the problem of childhood obesity, physicians may have become more likely to order tests or consultations specifically related to the treatment or evaluation of obesity. Other than the increase in the proportion of discharges with obesity as a comorbidity from 2000 to 2003, we were unable to explore these possible explanations with the KID datasets.

In this sample of discharges, with only 1.1% and 1.6% coded with obesity as a secondary diagnosis in 2000 and 2003, respectively, it is important to note that these discharges should not be interpreted as the prevalence of obesity in hospitalized children. Indeed, in a recent study of children hospitalized for surgical procedures at a large Midwestern tertiary care hospital, 31.6% were found to be overweight or obese.25 However, we posit that the cases coded with obesity as a secondary diagnosis in this sample represent the cases in which obesity presents a recognized factor that complicated the clinical course. Further work should explore the mechanisms by which obesity impacts the care of children hospitalized for common conditions. For example, children with obesity may require more procedures and may experience more treatment complications. These specific interventions should be the target of clinically focused analyses.

Limitations

Analyses utilizing discharge data are potentially limited by the accuracy and consistency of coding. Whether the discharges coded with obesity reflect all cases in which obesity was a complicating factor is not known. Based on the national prevalence of childhood obesity it is likely than more than 1.6% of the children hospitalized in 2003 were obese. However, whether obesity impacted the hospital course sufficiently to be included among the secondary diagnoses (as stipulated by ICD‐9‐CM guidelines for official recording)26 in more than 1.6% of cases is unknown.

This study is also limited by the inability to address the processes that might account for the consistently higher charges and longer LOS seen for those discharges coded with obesity versus those without obesity coded. The KID provides some information regarding procedures performed but cannot be reliably used to examine this aspect of patient care.27 An additional limitation of the KID data set is that it contains information about deidentified discharges. This leads to the possibility of having individual patients in the dataset with multiple hospitalizations. In this study we examined the relationship between obesity as a secondary diagnosis and incremental charges and LOS for the 4 most common clinical categories for which children are hospitalized. Findings may differ for other conditions not evaluated here. Finally, information regarding costs can only be inferred from the charge data provided by the KID. However, the ratio of charges to costs would not be expected to vary by obesity status.

CONCLUSIONS

These results extend our earlier findings of higher charges and longer LOS for pediatric discharges coded with obesity versus those without. In addition, this analysis suggests a widening gap of incremental hospital charges and LOS associated with obesity as a comorbidity for common pediatric conditions. These findings present a heightening financial imperative for further research to evaluate factors associated with greater resource utilization among obese pediatric patients.

With increases in the prevalence of obesity among children and adults over the past 3 decades in the United States,13 healthcare expenditures attributed to obesity have climbed steadily, to over $100 billion in excess expenditures annually.4 Several studies have examined healthcare costs associated with obesity in adults,48 but these studies have not attempted to distinguish between excess expenditures in inpatient versus outpatient settings. In contrast, the only 2 national economic analyses of childhood obesity have focused exclusively on the inpatient setting, because the health and economic consequences of obesity among children may be most apparent in cases in which obesity is causally linked to other diagnoses (eg, type 2 diabetes mellitus, gall bladder disease) or is a comorbidity that complicates hospitalizations.9, 10

In our previous study of obesity as a comorbidity for hospitalized children, we examined the incremental charges and length‐of‐stay (LOS) for hospitalizations for the most common nonpregnancy/nonchildbirth pediatric diagnoses, comparing those coded with obesity as a secondary diagnosis versus those without.10 Using data from the Agency for Healthcare Research and Quality (AHRQ) Kid's Inpatient Database (KID) for the year 2000, we found that obesity was associated with higher charges and longer LOS for all 4 of the conditions studied (asthma, pneumonia, affective disorders, and appendicitis). Our findings regarding asthma and affective disorders echoed earlier analyses of hospitalizations for conditions clinically linked to obesity.9 However, our study was the first to demonstrate that childhood obesity is a clinically and economically significant complicating factor for conditions not thought to be linked to obesity (pneumonia, appendicitis).

For this current study, our objective was to use more recent child hospitalization data from 2003 to determine whether our prior findings of incremental charges and LOS associated with hospitalizations where obesity was coded as a secondary diagnosis compared to those where it was not, were stable over time, and whether the magnitude of differences was consistent over a period of 4 years. We hypothesized that incremental differences in hospital charges and LOS between discharges with and without obesity would be seen in the 2003 data and that the magnitude of these differences in 2003 would be similar to those in 2000. Because obesity prevalence among children increased from 2000 to 2003,11 we also hypothesized that there would be a corresponding increase in the proportion of hospitalizations with obesity as a comorbidity.

METHODS

Data Source and Sample

We analyzed data from the AHRQ KID. The KID is a nationally representative sample of annual pediatric hospital discharges. Analysis using the KID allows for improved estimates due to the discharges from community, nonrehabilitation hospitals.12 It provides data found in standard hospital discharge abstracts for more than 2 million pediatric discharges, including International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes, LOS, total hospital charges, and patient demographic information.12 Our original analysis (published in Obesity, July 2007)10 utilized data from the 2000 KID. For this analysis we utilized data from the 2003 KID (the most recent version available), and for comparison we converted the results from the 2000 study into 2003 dollars using the Consumer Price Index for Medical Care.

Using ICD‐9‐CM codes, the KID provides the principal diagnosis for each discharge, along with up to 14 secondary diagnoses. It also provides Clinical Classification Software (CCS) codes, a diagnostic categorization scheme that permits grouping of related conditions. ICD‐9‐CM codes are collapsed into a smaller number of categories that are sometimes more useful for presenting descriptive statistics than are individual ICD‐9‐CM codes or the much broader categories of Diagnosis Related Groups (DRGs). For example, all ICD‐9‐CM codes for specific types of pneumonia would be grouped together under 1 CCS code but would exclude other respiratory conditions such as pneumothorax which would generally be included in the respiratory condition DRG.12

The 2000 KID contained 2,516,833 unweighted discharges, representing 7,291,038 discharges in the population. In the 2003 KID, there were 2,984,129 unweighted discharges representing 7,409,162 discharges in the population. Our sample included all discharges for nonpregnancy‐related conditions, in children 2 years of age (due to the Centers for Disease Control definition for overweight based on body mass index [BMI] that starts at age 2 years)13, 14 to 18 years of age (2000 weighted n = 1,527,309; 2003 weighted n = 1,613,258); these numbers exclude discharges with obesity as a primary diagnosis.

Key Variables

Our outcome variables were LOS and total charges for each of the common nonpregnancy‐related principal discharge diagnoses studied. For the 2000 and 2003 KID, total charges included all hospital fees with the exception of professional fees.15

The main independent variable of interest was presence of obesity as a secondary diagnosis. Discharges were classified as either with or without obesity based on the presence of the ICD‐9‐CM code 278.0x as a secondary diagnosis (1 if yes, 0 if no). This code captures obesity unspecified (278.00), overweight (278.01), and morbid obesity (278.02). Of note, the distribution of these codes did not vary significantly between the 2 study years.

Other independent variables included sex, age (2‐5 years, 6‐10 years, 11‐14 years, and 15‐18 years), race/ethnicity (white, black, Hispanic, and other), region (Northeast, Midwest, South, and West), hospital type (based on classification by the National Association of Children's Hospitals and Related Institutions [NACHRI] as general hospital, children's unit in a general hospital, and children's hospital) and expected primary payer (Medicaid, private, and other). We chose independent variables due to their established association with our outcomes and for their patterns of association with childhood obesity.

We did not include LOS as a covariate in models of charges because obesity may have been associated with the outcome indirectly through LOS as well as directly as a main effect. To fully interpret the combination of these effects would require analyses beyond the scope of this work.

Analyses

Using CCS codes, we identified the 4 most common principal nonpregnancy‐related discharge diagnoses for children 2‐18 years old. For both 2000 and 2003 these were asthma (CCS 128), pneumonia (CCS 122), affective disorders (eg, depression and bipolar disorder) (CCS 69), and appendicitis (CCS 142). Importantly, this group of diagnoses included conditions clinically associated with obesity (asthma and affective disorders)16 and conditions not associated with obesity (pneumonia and appendicitis). Given this distinction we analyzed the 4 conditions separately.

For all discharges with these common principal diagnoses, we calculated mean LOS and mean total charges. Bivariate and multivariable analyses were conducted using simple and multiple linear regression, respectively. These analyses were designed to test the study hypothesis that obesity as a secondary diagnosis is associated with incremental economic charges and LOS. All analyses were performed on log‐transformed LOS and charge data. We included in our models those characteristics that we hypothesized were potentially related to hospital charges and LOS, based on published literature,4, 17, 18 and for that reason all covariates were retained in the final models regardless of bivariate findings. Differences in the incremental LOS and charges for 2003 versus 2000 were compared using t‐tests.

For each independent variable with missing data, we included in the analyses a category for unreported values. The KID is known to have a large number of missing data for race/ethnicity; therefore, in keeping with other studies utilizing the KID,10, 19 we also conducted multivariate analyses excluding those discharges with unreported race as a sensitivity analysis. Of note, analyses of these data excluding children of unreported race were not substantively different than those in which the unreported group was included. We present our findings including the unreported race category.

Predicted values on the log scale, for those with obesity and without obesity as a secondary diagnosis adjusted for the listed covariates, were obtained. We then back‐transformed these to their original scales and units using methods developed by Duan.20 For each principal diagnosis category, we analyzed the differences in predicted mean LOS and predicted mean total charges between discharges with and without obesity as a secondary diagnosis, adjusted for the listed covariates, using the P values obtained from the regression analyses. All results are presented in 2003 dollars.

In keeping with our earlier analysis we considered the potential influence of comorbidities other than obesity on LOS and charges. Therefore, we examined whether other comorbidities were coded more frequently among those discharges with obesity as a secondary diagnosis than those discharges without obesity. As seen in the 2000 KID, the 2003 data revealed that diabetes was more commonly seen with obesity‐related hospitalizations than with those hospitalizations without obesity. However, the proportion of discharges with obesity and diabetes was low for all of the principal diagnostic categories studied (asthma 4.8%, pneumonia 6.0%, affective disorders 4.2%, and appendicitis 1.9%). Thus, we judged the co‐occurrence of diabetes and obesity as secondary diagnoses too infrequent to be an explanatory factor for the overall incremental differences in LOS and charges.

All analyses were weighted to account for the complex probability sampling of the dataset and permit inferences regarding national hospital discharge patterns. The same sample of discharges was used to analyze LOS and charges, with the discharge weighting variable (DISCWT) used for all analyses. All results are presented as weighted data unless otherwise noted. Analyses were conducted using STATA 8.0 (Stata Corporation, College Station, TX) and SUDAAN version 9 (Research Triangle Institute, Research Triangle Park, NC).

This study was approved by the Institutional Review Board of the University of Michigan Medical School.

RESULTS

Sample Characteristics

The characteristics of the study population are presented in Table 1. In 2003, the overall proportion of nonpregnancy‐related discharges for children 2‐18 years old coded with obesity as a secondary diagnosis was 1.6%, an increase from 1.1% in 2000. Within the 4 most common nonpregnancy‐related CCS category diagnoses (asthma, pneumonia, affective disorders, and appendicitis) the proportion of discharges with obesity coded as a secondary diagnosis increased from 2000 to 2003 (Figure 1)

Figure 1
Proportion of discharges with obesity coded as a secondary diagnosis for 2000 and 2003.
Characteristics of the Study Subpopulation from the 2000 and 2003 KID
VariablesDischarges
With Obesity as Secondary DiagnosisWithout Obesity
2000200320002003
Unweighted, n8,69615,546762,407943,182
Weighted population size17,67225,7091,509,6371,587,549
Age    
2‐5 years (%)4.84.827.429.0
6‐10 years (%)14.715.922.422.3
11‐14 years (%)34.434.120.920.9
15‐18 years (%)46.145.229.327.8
Sex    
Male (%)45.546.853.853.4
Race/Ethnicity    
White (%)46.832.250.939.3
Black (%)20.720.414.312.6
Hispanic (%)14.916.814.314.4
Other (%)4.85.05.65.6
Unreported (%)12.825.614.928.1
Payer    
Medicaid (%)42.646.532.136.9
Private (%)47.142.658.053.3
Other (%)9.410.69.49.6
Unreported (%)0.90.30.50.2
Hospital Region    
Northeast (%)17.315.921.718.7
Midwest (%)24.624.820.023.3
South (%)37.638.436.337.0
West (%)20.520.922.021.0
Hospital type    
General hospital (%)68.261.461.057.1
Children's unit in general hospital (%)15.217.818.619.2
Children's hospitals (%)14.314.917.917.6
Unreported (%)2.3%5.92.56.1

Incremental Differences in Mean Charges Associated with Obesity

In Table 2, we present results for analyses of mean charges. Following the pattern in 2000 for all 4 of these common conditions, in 2003 the adjusted mean total hospital charges were statistically significantly higher for discharges in which obesity was listed as a secondary diagnosis, compared with those in which it was not. Moreover, the magnitude of these differences was somewhat greater in 2003 than in 2000, although it did not achieve statistical significance (P > 0.05) (Figure 2). Specifically, the difference in charges among asthma discharges with and without obesity as a comorbidity was 9% greater in 2003 than in 2000, 17% greater among pneumonia discharges, 121% greater among affective disorders, and 3% greater among appendicitis discharges.

Figure 2
Differences in adjusted mean charges for discharges coded with and without obesity as a secondary diagnosis.
Adjusted Mean Charges for Discharges Coded with and Without Obesity as a Secondary Diagnosis in 2000 and 2003
 Adjusted Mean Charges ($)
20002003
With ObesityWithout ObesityDifferenceWith ObesityWithout ObesityDifference
  • NOTE: Values are given in 2003 dollars. All models adjusted for sex, age, race/ethnicity, region, hospital type, and expected primary payer.

  • <0.05.

  • <0.01.

Asthma8,8476,8841,963*10,5898,4442,145
Pneumonia13,93011,0362,894*16,60913,2193,390
Affective disorders9,4468,85059611,94210,6191,323
Appendicitis16,10112,5873,51419,21315,5863,627

Incremental Differences in Mean LOS Associated with Obesity

Compared with those discharges without obesity coded, obesity as a secondary diagnosis was associated with a statistically significantly longer mean LOS for all four diagnoses in 2003 (Table 3). In addition, for all diagnoses except asthma, the magnitude of the difference was somewhat greater in 2003 than in 2000, although it did not reach statistical significance (P > 0.05). The greatest increase was seen with appendicitis, with the incremental difference in LOS between those with obesity and those without going from 0.17 days in 2000 to 0.83 days in 2003; an increase of over 300%.

Adjusted Mean LOS for Discharges Coded with and Without Obesity as a Secondary Diagnosis in 2000 and 2003
 Adjusted Mean LOS
20002003
With ObesityWithout ObesityDifferenceWith ObesityWithout ObesityDifference
  • NOTE: All models adjusted for sex, age, race/ethnicity, region, hospital type, and expected primary payer.

  • <0.01.

  • <0.05.

Asthma3.042.450.59*2.882.440.44*
Pneumonia4.263.890.374.393.830.56
Affective disorders7.727.110.61*8.237.420.81*
Appendicitis3.333.160.173.913.080.83*

DISCUSSION

Prior studies have explored the resource utilization and expenditures associated with obesity in adult populations and among obese children in the outpatient setting.48, 21 Few, however, have examined charges related to inpatient care of obese children. Our studies are the first to utilize actual charge data from a nationally representative sample to explore the economic implications of obesity among children hospitalized for common pediatric illnesses.

Our findings from this national analysis support the hypothesis that, for the 4 conditions studied, statistically significantly higher mean total hospital charges and longer mean LOS for those discharges with obesity coded as a secondary diagnosis versus those without obesity coded occurred for both 2000 and 2003, even when controlling for sex, age, race/ethnicity, region, payer, and hospital type. Our analyses also suggested that the magnitude of the incremental differences in charges from 2000 to 2003 increased somewhat, and the magnitude of the incremental differences in LOS for all of these common conditions (except asthma) is also increasing.

While these findings serve to confirm higher incremental charges and LOS associated with obesity for hospitalized children, they raise the question of why charges and LOS for children with obesity might increase at a greater rate than for those without obesity. Higher hospital charges and LOS for children with obesity coded as a secondary diagnosis may be explained by greater resource utilization due to obesity that: 1) increases the technical complexity of procedures such as surgical interventions or intravenous catheter (IV) placement;22 2) leads to greater illness severity, as has been suggested in studies of adult patients;23, 24 or 3) leads to more complications such as secondary infections.22 One explanation for the possible widening of the gap in charges during the time period studied might be that discharges coded with obesity in 2003 reflect children who were more severely obese and had a greater severity of illness, leading to higher resource utilization than those with obesity in the 2000 dataset. However, the ICD‐9‐CM code for morbid obesity (278.02) was not used more often in 2003 than in 2000. Alternatively, we suspect that between 2000 and 2003, due to an increasing awareness of the problem of childhood obesity, physicians may have become more likely to order tests or consultations specifically related to the treatment or evaluation of obesity. Other than the increase in the proportion of discharges with obesity as a comorbidity from 2000 to 2003, we were unable to explore these possible explanations with the KID datasets.

In this sample of discharges, with only 1.1% and 1.6% coded with obesity as a secondary diagnosis in 2000 and 2003, respectively, it is important to note that these discharges should not be interpreted as the prevalence of obesity in hospitalized children. Indeed, in a recent study of children hospitalized for surgical procedures at a large Midwestern tertiary care hospital, 31.6% were found to be overweight or obese.25 However, we posit that the cases coded with obesity as a secondary diagnosis in this sample represent the cases in which obesity presents a recognized factor that complicated the clinical course. Further work should explore the mechanisms by which obesity impacts the care of children hospitalized for common conditions. For example, children with obesity may require more procedures and may experience more treatment complications. These specific interventions should be the target of clinically focused analyses.

Limitations

Analyses utilizing discharge data are potentially limited by the accuracy and consistency of coding. Whether the discharges coded with obesity reflect all cases in which obesity was a complicating factor is not known. Based on the national prevalence of childhood obesity it is likely than more than 1.6% of the children hospitalized in 2003 were obese. However, whether obesity impacted the hospital course sufficiently to be included among the secondary diagnoses (as stipulated by ICD‐9‐CM guidelines for official recording)26 in more than 1.6% of cases is unknown.

This study is also limited by the inability to address the processes that might account for the consistently higher charges and longer LOS seen for those discharges coded with obesity versus those without obesity coded. The KID provides some information regarding procedures performed but cannot be reliably used to examine this aspect of patient care.27 An additional limitation of the KID data set is that it contains information about deidentified discharges. This leads to the possibility of having individual patients in the dataset with multiple hospitalizations. In this study we examined the relationship between obesity as a secondary diagnosis and incremental charges and LOS for the 4 most common clinical categories for which children are hospitalized. Findings may differ for other conditions not evaluated here. Finally, information regarding costs can only be inferred from the charge data provided by the KID. However, the ratio of charges to costs would not be expected to vary by obesity status.

CONCLUSIONS

These results extend our earlier findings of higher charges and longer LOS for pediatric discharges coded with obesity versus those without. In addition, this analysis suggests a widening gap of incremental hospital charges and LOS associated with obesity as a comorbidity for common pediatric conditions. These findings present a heightening financial imperative for further research to evaluate factors associated with greater resource utilization among obese pediatric patients.

References
  1. Ogden CL,Flegal KM,Carroll MD,Johnson CL.Prevalence and trends in overweight among US children and adolescents, 1999–2000.JAMA.2002;288(14):17281732.
  2. Strauss RS,Pollack HA.Epidemic increase in childhood overweight, 1986–1998.JAMA.2001;286(22):28452848.
  3. Troiano RP,Flegal KM.Overweight children and adolescents: description, epidemiology, and demographics.Pediatrics.1998;101(Pt 2):497504.
  4. Finkelstein EA,Fiebelkorn IC,Wang G.National medical spending attributable to overweight and obesity: how much, and who's paying?Health Aff (Millwood).2003; (Suppl Web Exclusives):W3‐21926.
  5. Thorpe KE,Florence CS,Howard DH,Joski P.The impact of obesity on rising medical spending.Health Aff (Millwood).2004;(Suppl Web Exclusives):W4‐4806.
  6. Wolf AM,Colditz GA.Current estimates of the economic cost of obesity in the United States.Obes Res.1998;6(2):97106.
  7. Oster G,Thompson D,Edelsberg J,Bird AP,Colditz GA.Lifetime health and economic benefits of weight loss among obese persons.Am J Public Health.1999;89(10):15361542.
  8. Lakdawalla DN,Goldman DP,Shang B.The health and cost consequences of obesity among the future elderly.Health Aff (Millwood).2005;24(Suppl 2):W5R30W5R41.
  9. Wang G,Dietz WH.Economic burden of obesity in youths aged 6 to 17 years: 1979–1999.Pediatrics.2002;109(5):E81E81.
  10. Woolford SJ,Gebremariam A,Clark SJ,Davis MM.Incremental hospital charges associated with obesity as a secondary diagnosis.Obesity (Silver Spring).2007;15:18951901.
  11. Ogden CL,Carroll MD,Curtin LR,McDowell MA,Tabak CJ,Flegal KM.Prevalence of overweight and obesity in the United States, 1999–2004.JAMA.2006;295(13):15491555.
  12. Healthcare Cost and Utilization Project.2005. Overview of the Kid's Inpatient Database. Available at:http://www.hcup‐us.ahrq.gov/kidoverview.jsp. Accessed December 2008.
  13. CDC Body Mass Index: BMI for Children and Teens. Available at: http://www.cdc.gov/nccdphp/dnpa/bmi. Accessed December2008.
  14. Ogden CL,Troiano RP,Briefel RR,Kuczmarski RJ,Flegal KM,Johnson CL.Prevalence of overweight among preschool children in the United States, 1971 through 1994.Pediatrics.1997;99(4):E1.
  15. Healthcare Cost and Utilization Project, 2002 and 2004. Description of data elements: inpatient core file. Available at: http://www.hcup‐us.ahrq.gov/db/nation/kid/DataElements_KID_Core_2000.pdf; http://www.hcup‐us.ahrq.gov/db/nation/kid/KID_2003_CORE_Volume1_A‐L.pdf;http://www.hcup‐us. ahrq.gov/db/nation/kid/KID_2003_CORE_Volume2_M‐Z.pdf. Accessed December2008.
  16. Dietz WH.Health consequences of obesity in youth: childhood predictors of adult disease.Pediatrics.1998;101:518525.
  17. Merenstein D,Egleston B,Diener‐West M.Lengths of stay and costs associated with children's hospitals.Pediatrics.2005;115(4):839844.
  18. Wee CC,Phillips RS,Legedza AT, et al.Health care expenditures associated with overweight and obesity among US adults: importance of age and race.Am J Public Health.2005;95(1):159165.
  19. Smink DS,Fishman SJ,Kleinman K,Finkelstein JA.Effects of race, insurance status, and hospital volume on perforated appendicitis in children.Pediatrics.2005;115(4):920925.
  20. Duan N.Smearing estimate: a nonparametric retransformation method.J Am Stat Assoc.1983;78:605610.
  21. Hampl SE,Carroll CA,Simon SD,Sharma V.Resource utilization and expenditures for overweight and obese children.Arch Pediatr Adolesc Med.2007 Jan;161(1):1114.
  22. Davies DA,Yanchar NL.Appendicitis in the obese child.J Pediatr Surg.2007;42(5):857861.
  23. Varon J,Marik P.Management of the obese critically ill patient.Crit Care Clin.2001;17:187200.
  24. Pelosi P,Croci M,Ravagnan I,Vicardi P,Gattinoni L.Total respiratory system, lung, and chest wall mechanics in sedated‐paralyzed postoperative morbidly obese patients.Chest.1996;109:144151.
  25. Nafiu OO,Ndao‐Brumlay KS,Bamgbade OA,Morris M,Kasa‐Vubu JZ.Prevalence of overweight and obesity in a U.S. pediatric surgical population.J Natl Med Assoc.2007;99(1):4648, 50–51.
  26. Centers for Disease Control and Prevention. ICD‐9‐CM. Official Guidelines for Coding and Reporting. Effective April 1, 2005. Available at: http://www.cdc.gov/nchs/data/icd9/icdguide.pdf. Accessed December2008.
  27. Gupta RS,Meenakshi B,Prosser LA,Finkelstein JA.Predictors of hospital charges for children admitted with asthma.Ambul Pediatr.2006;6(1):1520.
References
  1. Ogden CL,Flegal KM,Carroll MD,Johnson CL.Prevalence and trends in overweight among US children and adolescents, 1999–2000.JAMA.2002;288(14):17281732.
  2. Strauss RS,Pollack HA.Epidemic increase in childhood overweight, 1986–1998.JAMA.2001;286(22):28452848.
  3. Troiano RP,Flegal KM.Overweight children and adolescents: description, epidemiology, and demographics.Pediatrics.1998;101(Pt 2):497504.
  4. Finkelstein EA,Fiebelkorn IC,Wang G.National medical spending attributable to overweight and obesity: how much, and who's paying?Health Aff (Millwood).2003; (Suppl Web Exclusives):W3‐21926.
  5. Thorpe KE,Florence CS,Howard DH,Joski P.The impact of obesity on rising medical spending.Health Aff (Millwood).2004;(Suppl Web Exclusives):W4‐4806.
  6. Wolf AM,Colditz GA.Current estimates of the economic cost of obesity in the United States.Obes Res.1998;6(2):97106.
  7. Oster G,Thompson D,Edelsberg J,Bird AP,Colditz GA.Lifetime health and economic benefits of weight loss among obese persons.Am J Public Health.1999;89(10):15361542.
  8. Lakdawalla DN,Goldman DP,Shang B.The health and cost consequences of obesity among the future elderly.Health Aff (Millwood).2005;24(Suppl 2):W5R30W5R41.
  9. Wang G,Dietz WH.Economic burden of obesity in youths aged 6 to 17 years: 1979–1999.Pediatrics.2002;109(5):E81E81.
  10. Woolford SJ,Gebremariam A,Clark SJ,Davis MM.Incremental hospital charges associated with obesity as a secondary diagnosis.Obesity (Silver Spring).2007;15:18951901.
  11. Ogden CL,Carroll MD,Curtin LR,McDowell MA,Tabak CJ,Flegal KM.Prevalence of overweight and obesity in the United States, 1999–2004.JAMA.2006;295(13):15491555.
  12. Healthcare Cost and Utilization Project.2005. Overview of the Kid's Inpatient Database. Available at:http://www.hcup‐us.ahrq.gov/kidoverview.jsp. Accessed December 2008.
  13. CDC Body Mass Index: BMI for Children and Teens. Available at: http://www.cdc.gov/nccdphp/dnpa/bmi. Accessed December2008.
  14. Ogden CL,Troiano RP,Briefel RR,Kuczmarski RJ,Flegal KM,Johnson CL.Prevalence of overweight among preschool children in the United States, 1971 through 1994.Pediatrics.1997;99(4):E1.
  15. Healthcare Cost and Utilization Project, 2002 and 2004. Description of data elements: inpatient core file. Available at: http://www.hcup‐us.ahrq.gov/db/nation/kid/DataElements_KID_Core_2000.pdf; http://www.hcup‐us.ahrq.gov/db/nation/kid/KID_2003_CORE_Volume1_A‐L.pdf;http://www.hcup‐us. ahrq.gov/db/nation/kid/KID_2003_CORE_Volume2_M‐Z.pdf. Accessed December2008.
  16. Dietz WH.Health consequences of obesity in youth: childhood predictors of adult disease.Pediatrics.1998;101:518525.
  17. Merenstein D,Egleston B,Diener‐West M.Lengths of stay and costs associated with children's hospitals.Pediatrics.2005;115(4):839844.
  18. Wee CC,Phillips RS,Legedza AT, et al.Health care expenditures associated with overweight and obesity among US adults: importance of age and race.Am J Public Health.2005;95(1):159165.
  19. Smink DS,Fishman SJ,Kleinman K,Finkelstein JA.Effects of race, insurance status, and hospital volume on perforated appendicitis in children.Pediatrics.2005;115(4):920925.
  20. Duan N.Smearing estimate: a nonparametric retransformation method.J Am Stat Assoc.1983;78:605610.
  21. Hampl SE,Carroll CA,Simon SD,Sharma V.Resource utilization and expenditures for overweight and obese children.Arch Pediatr Adolesc Med.2007 Jan;161(1):1114.
  22. Davies DA,Yanchar NL.Appendicitis in the obese child.J Pediatr Surg.2007;42(5):857861.
  23. Varon J,Marik P.Management of the obese critically ill patient.Crit Care Clin.2001;17:187200.
  24. Pelosi P,Croci M,Ravagnan I,Vicardi P,Gattinoni L.Total respiratory system, lung, and chest wall mechanics in sedated‐paralyzed postoperative morbidly obese patients.Chest.1996;109:144151.
  25. Nafiu OO,Ndao‐Brumlay KS,Bamgbade OA,Morris M,Kasa‐Vubu JZ.Prevalence of overweight and obesity in a U.S. pediatric surgical population.J Natl Med Assoc.2007;99(1):4648, 50–51.
  26. Centers for Disease Control and Prevention. ICD‐9‐CM. Official Guidelines for Coding and Reporting. Effective April 1, 2005. Available at: http://www.cdc.gov/nchs/data/icd9/icdguide.pdf. Accessed December2008.
  27. Gupta RS,Meenakshi B,Prosser LA,Finkelstein JA.Predictors of hospital charges for children admitted with asthma.Ambul Pediatr.2006;6(1):1520.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
149-156
Page Number
149-156
Article Type
Display Headline
Persistent gap of incremental charges for obesity as a secondary diagnosis in common pediatric hospitalizations
Display Headline
Persistent gap of incremental charges for obesity as a secondary diagnosis in common pediatric hospitalizations
Legacy Keywords
charges, comorbidity, economics, hospitalization, obesity, pediatrics, secondary diagnosis
Legacy Keywords
charges, comorbidity, economics, hospitalization, obesity, pediatrics, secondary diagnosis
Sections
Article Source

Copyright © 2009 Society of Hospital Medicine

Disallow All Ads
Correspondence Location
300 NIB, Room 6D22, Campus Box 0456, Ann Arbor, MI 48109‐0456
Content Gating
No Gating (article Unlocked/Free)
Alternative CME
Article PDF Media
Media Files

Symmetrical drug‐related intertriginous and flexural exanthema after coronary artery angiography

Article Type
Changed
Mon, 01/02/2017 - 19:34
Display Headline
Symmetrical drug‐related intertriginous and flexural exanthema after coronary artery angiography

A 57‐year‐old woman developed a pruritic rash 6 hours after undergoing coronary angiography. On exam, symmetrical, eczematous plaques were noted in her bilateral groin (Figure 1), buttocks, axillae (Figure 2), and the intertriginous folds of her breasts. No palmar, plantar, or mucosal lesions were noted and laboratory tests were normal. This patient presents with symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) secondary to iodine‐based contrast dye. It is a type IV hypersensitivity reaction most often reported to nickel, mercury, and systemic antibiotics, although previous sensitization is often unknown. Also called baboon syndrome because its distribution mimics the pink bottom of a baboon, SDRIFE appears hours to days after exposure to the offending agent. The unusual distribution may be explained by high concentrations of the allergen in sweat. Resolution is typical with discontinuation of the offending drug, although antihistamines, topical steroids, and possibly oral steroids may be useful adjuncts.

Figure 1
View of right groin of patient with baboon syndrome.
Figure 2
Right axilla of patient with baboon syndrome.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
203-203
Sections
Article PDF
Article PDF

A 57‐year‐old woman developed a pruritic rash 6 hours after undergoing coronary angiography. On exam, symmetrical, eczematous plaques were noted in her bilateral groin (Figure 1), buttocks, axillae (Figure 2), and the intertriginous folds of her breasts. No palmar, plantar, or mucosal lesions were noted and laboratory tests were normal. This patient presents with symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) secondary to iodine‐based contrast dye. It is a type IV hypersensitivity reaction most often reported to nickel, mercury, and systemic antibiotics, although previous sensitization is often unknown. Also called baboon syndrome because its distribution mimics the pink bottom of a baboon, SDRIFE appears hours to days after exposure to the offending agent. The unusual distribution may be explained by high concentrations of the allergen in sweat. Resolution is typical with discontinuation of the offending drug, although antihistamines, topical steroids, and possibly oral steroids may be useful adjuncts.

Figure 1
View of right groin of patient with baboon syndrome.
Figure 2
Right axilla of patient with baboon syndrome.

A 57‐year‐old woman developed a pruritic rash 6 hours after undergoing coronary angiography. On exam, symmetrical, eczematous plaques were noted in her bilateral groin (Figure 1), buttocks, axillae (Figure 2), and the intertriginous folds of her breasts. No palmar, plantar, or mucosal lesions were noted and laboratory tests were normal. This patient presents with symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) secondary to iodine‐based contrast dye. It is a type IV hypersensitivity reaction most often reported to nickel, mercury, and systemic antibiotics, although previous sensitization is often unknown. Also called baboon syndrome because its distribution mimics the pink bottom of a baboon, SDRIFE appears hours to days after exposure to the offending agent. The unusual distribution may be explained by high concentrations of the allergen in sweat. Resolution is typical with discontinuation of the offending drug, although antihistamines, topical steroids, and possibly oral steroids may be useful adjuncts.

Figure 1
View of right groin of patient with baboon syndrome.
Figure 2
Right axilla of patient with baboon syndrome.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
203-203
Page Number
203-203
Article Type
Display Headline
Symmetrical drug‐related intertriginous and flexural exanthema after coronary artery angiography
Display Headline
Symmetrical drug‐related intertriginous and flexural exanthema after coronary artery angiography
Sections
Article Source
Copyright © 2009 Society of Hospital Medicine
Disallow All Ads
Correspondence Location
California Pacific Medical Center, Internal Medicine, 2333 Buchanan, San Francisco, CA 94115
Content Gating
Gated (full article locked unless allowed per User)
Gating Strategy
First Peek Free
Article PDF Media

Out of Africa

Article Type
Changed
Mon, 01/02/2017 - 19:34
Display Headline
Out of Africa

I knew that he was going to die. I do not remember when it became evident to me, and I was not sure how to tell the family. I thought that I could arrange a family meeting and inform them of the sad reality in a calm, sympathetic manner. The patient had chronic lymphocytic leukemia, and his case was advanced. The only medication available to him was chlorambucil. As the days passed, I could not bring myself to call the family meeting because they had so much hope. Every day as we got results and I shared them, I would sandwich the bad news with some optimism to ease their pain. Well, his white blood cell count has come down, but his platelet count and red blood cell counts are very low, and this puts him in danger of bleeding. The medicine is bringing the white cell count down but has not yet brought the other cell counts up. What we can do is give him some blood. I tried not to allow despair to creep into my thoughts or my voice. I knew that the blood bank had no platelets or packed red blood cells. He was not eating or drinking, and we had placed a nasogastric tube through which his family fed him wheat or millet porridge (manufactured tube feeds are not widely available in Uganda). I tried not to think about the time that he had almost died a few weeks before.

I had been called to the bedside because the patient was in respiratory distress. The doctor on call was in his office when I arrived, and I wondered why he was not at the bedside. I took one look at the patient and had to step away for a moment to compose myself. I felt the tears threatening to come, but I had to stop them. This was not the time for emotions. I had to assess the patient and make some quick decisions. The doctor on call seemed to have given up. He was a young trainee in a system in which you treat when you can and, if the situation is hopeless, you move on to the next patient. There are no resources for perpetuating hope. This is so different from my practice in the United States, where if a patient wants everything done, we will do it. We are not taught when to give up hope, and futility does not figure into the allocation of resources. I looked at the patient struggling to breathe and felt that I had to do all that I could for him. I asked the doctor on call to place the patient on oxygen and hoped that the tanks were not empty. I was worried about a lot of things, such as pulmonary embolus, myocardial infarction, and pneumonia. Diagnosing any of these would not be easy (the hospital did not have a computed tomography scanner, and obtaining cardiac enzymes was not as simple as clicking a button on a computer). First things first: the chest X‐ray. I thanked God that we were in a private hospital, one of the best in the city of Kampala, so we were able to get a chest X‐ray right away. As we transported the patient (portable X‐rays are nonexistent), the resident told me that he had called the consultant (the equivalent of an attending physician in the United States), who happened to be out of town. The consultant instructed us to transfer the patient to Mulago Hospital (the largest tertiary center in Uganda with well over 1000 beds and some of the equipment that you might find in an American hospital). I wondered how an attending physician could be out of town and leave a resident in charge. The thought was disturbing, but I had no time to ponder it. I later learned that physicians are so poorly paid that many have their own private clinics. My patient got the X‐ray, and I reviewed it with the resident. Tuberculosis, he said. Tuberculosis was this resident's reality. Many patients who need chest X‐rays in Uganda have tuberculosis. As I reviewed the X‐ray, though, I was certain that this was congestive heart failure. However, in Uganda, congestive heart failure is rarely diagnosed in the hospital. Patients with an ejection fraction low enough to cause congestion generally die before they get to a hospital. I knew that some furosemide would work for this patient, but I could not get the resident to listen to me. He had orders from the consultant to transfer the patient immediately, and the ambulance was ready. I tried to convince the resident to administer furosemide before transferring the patient, but he feared administering a drug not approved by his superior. As the patient was loaded onto the ambulance, I reflected for a second on how different things would be if we were in the United States. We arrived at Mulago in record time, and I tried to get the intake doctors to understand what the problem was; however, they did not want to hear from the US doctor. I stared in frustration as they wasted valuable time. I wondered how long the patient would survive in respiratory distress with nothing being done. I called the patient's son and asked him to come to Mulago immediately. Miraculously, he had already been on his way. As I held the patient's hand, sure that he would die right then and there in a waiting area as nobody did anything, I saw the patient's son. I knew that he was a pharmacist, and I asked him to go to the pharmacy and buy furosemide and some syringes. In Uganda, one can buy any medication without a prescription. Luckily, the hospital pharmacy had the drug. We treated the patient, and in no time, his breathing had returned to normal.

I was jolted back to reality. He was dying, and I knew it. He had had many close calls. There was the time that he got the wrong blood during a blood transfusion. I informed the doctor on call as the blood was being administered that I thought the patient was getting a transfusion reaction because he had rigors. The physician on call suggested covering him in blankets, and I suggested stopping the infusion and administering steroids. The pack of blood showed that he was getting his blood type. The patient was typed and crossed again, and to our surprise, we got a different result. I went to the laboratory to perform a third, tie‐breaking cross match and was surprised to note that the reagents had passed their expiration date. However, I knew that these were small battles we were winning and that there was no winning the war.

I recognized that the challenges of practicing medicine in the developing world were many. I wondered how the patients of families with fewer resources survived. The answer was obvious: they didn't. I personally picked up blood when it was available from the blood bank and vividly remember walking from the blood bank at night to the private hospital with units of blood in each hand. Once we arrived at the hospital, I had to warm the blood to room temperature by holding it close to my own skin. Many tests that we perform routinely on a hospitalized patient in the United States are not available.

There was still the problem of breaking the news to the family. Despite everything that had been done and the many near misses that the patient had survived, he was still going to die. It turns out that the family was more intuitive than I thought. One day, the son came to me and asked how long his dad had. Not long, I said quietly. I thought about all that I could potentially do if I had the patient in the hospital at which I worked in the United States. Would it have made a difference? I do not know. It was impossible doctoring this patient, and I suspect doing it in a resource‐rich environment would not have made it any easier. You see this patient, perhaps the most important patient of my life, certainly a patient that I will never forget, was my father.

It had been 15 years since I had traveled to the United States for an education. I knew that my father was so incredibly proud of me. I think that he was the happiest I had ever seen him when he attended my graduation from medical school in Minnesota. I had been looking forward to this visit back home because it had been 3 years since I had last seen my family. I was somewhat concerned because my father had told me a week before I traveled that he was not feeling well. When I arrived, there seemed to be relief on my brother's face when he met me at the airport. We drove straight to the hospital, and along with the joy of seeing me, I could sense that my father was glad that I was home at this particular point in time. They had just received the diagnosis. He had leukemia, and they were glad that their doctor was home. They had particular faith in the daughter (sister) sent abroad for an education. Things would now be okay. Initially, I never got to choose the role of doctor that I played in the final chapter of my father's life. The decision was made for me out of my family's desperation to make sure that they had left no stone unturned to help my father, and I accepted it out of necessity. As my father became my father when I entered this world, I became his doctor when he was leaving it; there was never any question in my mind, as there never was in his. As it became clear that my father would not survive, I chose to continue the role of doctor. I have watched many patients die as a physician and have done my best to make sure that their passing is comfortable, peaceful, and dignified. The doctor could help this patient die, but the daughter could not watch her father go. When it was evident that he had only days to live and did not need this doctor or know his daughter, I flew back to the United States. Three days later my father died. I was not physically at his bedside, but my spirit was. I have no regrets. Although the head knows that he passed on, in my mind's eye, he is laughing and has a twinkle in his eye. I could not bear to see him without life. A piece of my heart is buried with him, and for this reason, I will never be out of Africa.

Acknowledgements

The author is indebted to J.B. Kisuule and seeks to honor his life of service. Thank you to Dr. Roy Ziegelstein for his help with this article.

Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
204-206
Sections
Article PDF
Article PDF

I knew that he was going to die. I do not remember when it became evident to me, and I was not sure how to tell the family. I thought that I could arrange a family meeting and inform them of the sad reality in a calm, sympathetic manner. The patient had chronic lymphocytic leukemia, and his case was advanced. The only medication available to him was chlorambucil. As the days passed, I could not bring myself to call the family meeting because they had so much hope. Every day as we got results and I shared them, I would sandwich the bad news with some optimism to ease their pain. Well, his white blood cell count has come down, but his platelet count and red blood cell counts are very low, and this puts him in danger of bleeding. The medicine is bringing the white cell count down but has not yet brought the other cell counts up. What we can do is give him some blood. I tried not to allow despair to creep into my thoughts or my voice. I knew that the blood bank had no platelets or packed red blood cells. He was not eating or drinking, and we had placed a nasogastric tube through which his family fed him wheat or millet porridge (manufactured tube feeds are not widely available in Uganda). I tried not to think about the time that he had almost died a few weeks before.

I had been called to the bedside because the patient was in respiratory distress. The doctor on call was in his office when I arrived, and I wondered why he was not at the bedside. I took one look at the patient and had to step away for a moment to compose myself. I felt the tears threatening to come, but I had to stop them. This was not the time for emotions. I had to assess the patient and make some quick decisions. The doctor on call seemed to have given up. He was a young trainee in a system in which you treat when you can and, if the situation is hopeless, you move on to the next patient. There are no resources for perpetuating hope. This is so different from my practice in the United States, where if a patient wants everything done, we will do it. We are not taught when to give up hope, and futility does not figure into the allocation of resources. I looked at the patient struggling to breathe and felt that I had to do all that I could for him. I asked the doctor on call to place the patient on oxygen and hoped that the tanks were not empty. I was worried about a lot of things, such as pulmonary embolus, myocardial infarction, and pneumonia. Diagnosing any of these would not be easy (the hospital did not have a computed tomography scanner, and obtaining cardiac enzymes was not as simple as clicking a button on a computer). First things first: the chest X‐ray. I thanked God that we were in a private hospital, one of the best in the city of Kampala, so we were able to get a chest X‐ray right away. As we transported the patient (portable X‐rays are nonexistent), the resident told me that he had called the consultant (the equivalent of an attending physician in the United States), who happened to be out of town. The consultant instructed us to transfer the patient to Mulago Hospital (the largest tertiary center in Uganda with well over 1000 beds and some of the equipment that you might find in an American hospital). I wondered how an attending physician could be out of town and leave a resident in charge. The thought was disturbing, but I had no time to ponder it. I later learned that physicians are so poorly paid that many have their own private clinics. My patient got the X‐ray, and I reviewed it with the resident. Tuberculosis, he said. Tuberculosis was this resident's reality. Many patients who need chest X‐rays in Uganda have tuberculosis. As I reviewed the X‐ray, though, I was certain that this was congestive heart failure. However, in Uganda, congestive heart failure is rarely diagnosed in the hospital. Patients with an ejection fraction low enough to cause congestion generally die before they get to a hospital. I knew that some furosemide would work for this patient, but I could not get the resident to listen to me. He had orders from the consultant to transfer the patient immediately, and the ambulance was ready. I tried to convince the resident to administer furosemide before transferring the patient, but he feared administering a drug not approved by his superior. As the patient was loaded onto the ambulance, I reflected for a second on how different things would be if we were in the United States. We arrived at Mulago in record time, and I tried to get the intake doctors to understand what the problem was; however, they did not want to hear from the US doctor. I stared in frustration as they wasted valuable time. I wondered how long the patient would survive in respiratory distress with nothing being done. I called the patient's son and asked him to come to Mulago immediately. Miraculously, he had already been on his way. As I held the patient's hand, sure that he would die right then and there in a waiting area as nobody did anything, I saw the patient's son. I knew that he was a pharmacist, and I asked him to go to the pharmacy and buy furosemide and some syringes. In Uganda, one can buy any medication without a prescription. Luckily, the hospital pharmacy had the drug. We treated the patient, and in no time, his breathing had returned to normal.

I was jolted back to reality. He was dying, and I knew it. He had had many close calls. There was the time that he got the wrong blood during a blood transfusion. I informed the doctor on call as the blood was being administered that I thought the patient was getting a transfusion reaction because he had rigors. The physician on call suggested covering him in blankets, and I suggested stopping the infusion and administering steroids. The pack of blood showed that he was getting his blood type. The patient was typed and crossed again, and to our surprise, we got a different result. I went to the laboratory to perform a third, tie‐breaking cross match and was surprised to note that the reagents had passed their expiration date. However, I knew that these were small battles we were winning and that there was no winning the war.

I recognized that the challenges of practicing medicine in the developing world were many. I wondered how the patients of families with fewer resources survived. The answer was obvious: they didn't. I personally picked up blood when it was available from the blood bank and vividly remember walking from the blood bank at night to the private hospital with units of blood in each hand. Once we arrived at the hospital, I had to warm the blood to room temperature by holding it close to my own skin. Many tests that we perform routinely on a hospitalized patient in the United States are not available.

There was still the problem of breaking the news to the family. Despite everything that had been done and the many near misses that the patient had survived, he was still going to die. It turns out that the family was more intuitive than I thought. One day, the son came to me and asked how long his dad had. Not long, I said quietly. I thought about all that I could potentially do if I had the patient in the hospital at which I worked in the United States. Would it have made a difference? I do not know. It was impossible doctoring this patient, and I suspect doing it in a resource‐rich environment would not have made it any easier. You see this patient, perhaps the most important patient of my life, certainly a patient that I will never forget, was my father.

It had been 15 years since I had traveled to the United States for an education. I knew that my father was so incredibly proud of me. I think that he was the happiest I had ever seen him when he attended my graduation from medical school in Minnesota. I had been looking forward to this visit back home because it had been 3 years since I had last seen my family. I was somewhat concerned because my father had told me a week before I traveled that he was not feeling well. When I arrived, there seemed to be relief on my brother's face when he met me at the airport. We drove straight to the hospital, and along with the joy of seeing me, I could sense that my father was glad that I was home at this particular point in time. They had just received the diagnosis. He had leukemia, and they were glad that their doctor was home. They had particular faith in the daughter (sister) sent abroad for an education. Things would now be okay. Initially, I never got to choose the role of doctor that I played in the final chapter of my father's life. The decision was made for me out of my family's desperation to make sure that they had left no stone unturned to help my father, and I accepted it out of necessity. As my father became my father when I entered this world, I became his doctor when he was leaving it; there was never any question in my mind, as there never was in his. As it became clear that my father would not survive, I chose to continue the role of doctor. I have watched many patients die as a physician and have done my best to make sure that their passing is comfortable, peaceful, and dignified. The doctor could help this patient die, but the daughter could not watch her father go. When it was evident that he had only days to live and did not need this doctor or know his daughter, I flew back to the United States. Three days later my father died. I was not physically at his bedside, but my spirit was. I have no regrets. Although the head knows that he passed on, in my mind's eye, he is laughing and has a twinkle in his eye. I could not bear to see him without life. A piece of my heart is buried with him, and for this reason, I will never be out of Africa.

Acknowledgements

The author is indebted to J.B. Kisuule and seeks to honor his life of service. Thank you to Dr. Roy Ziegelstein for his help with this article.

I knew that he was going to die. I do not remember when it became evident to me, and I was not sure how to tell the family. I thought that I could arrange a family meeting and inform them of the sad reality in a calm, sympathetic manner. The patient had chronic lymphocytic leukemia, and his case was advanced. The only medication available to him was chlorambucil. As the days passed, I could not bring myself to call the family meeting because they had so much hope. Every day as we got results and I shared them, I would sandwich the bad news with some optimism to ease their pain. Well, his white blood cell count has come down, but his platelet count and red blood cell counts are very low, and this puts him in danger of bleeding. The medicine is bringing the white cell count down but has not yet brought the other cell counts up. What we can do is give him some blood. I tried not to allow despair to creep into my thoughts or my voice. I knew that the blood bank had no platelets or packed red blood cells. He was not eating or drinking, and we had placed a nasogastric tube through which his family fed him wheat or millet porridge (manufactured tube feeds are not widely available in Uganda). I tried not to think about the time that he had almost died a few weeks before.

I had been called to the bedside because the patient was in respiratory distress. The doctor on call was in his office when I arrived, and I wondered why he was not at the bedside. I took one look at the patient and had to step away for a moment to compose myself. I felt the tears threatening to come, but I had to stop them. This was not the time for emotions. I had to assess the patient and make some quick decisions. The doctor on call seemed to have given up. He was a young trainee in a system in which you treat when you can and, if the situation is hopeless, you move on to the next patient. There are no resources for perpetuating hope. This is so different from my practice in the United States, where if a patient wants everything done, we will do it. We are not taught when to give up hope, and futility does not figure into the allocation of resources. I looked at the patient struggling to breathe and felt that I had to do all that I could for him. I asked the doctor on call to place the patient on oxygen and hoped that the tanks were not empty. I was worried about a lot of things, such as pulmonary embolus, myocardial infarction, and pneumonia. Diagnosing any of these would not be easy (the hospital did not have a computed tomography scanner, and obtaining cardiac enzymes was not as simple as clicking a button on a computer). First things first: the chest X‐ray. I thanked God that we were in a private hospital, one of the best in the city of Kampala, so we were able to get a chest X‐ray right away. As we transported the patient (portable X‐rays are nonexistent), the resident told me that he had called the consultant (the equivalent of an attending physician in the United States), who happened to be out of town. The consultant instructed us to transfer the patient to Mulago Hospital (the largest tertiary center in Uganda with well over 1000 beds and some of the equipment that you might find in an American hospital). I wondered how an attending physician could be out of town and leave a resident in charge. The thought was disturbing, but I had no time to ponder it. I later learned that physicians are so poorly paid that many have their own private clinics. My patient got the X‐ray, and I reviewed it with the resident. Tuberculosis, he said. Tuberculosis was this resident's reality. Many patients who need chest X‐rays in Uganda have tuberculosis. As I reviewed the X‐ray, though, I was certain that this was congestive heart failure. However, in Uganda, congestive heart failure is rarely diagnosed in the hospital. Patients with an ejection fraction low enough to cause congestion generally die before they get to a hospital. I knew that some furosemide would work for this patient, but I could not get the resident to listen to me. He had orders from the consultant to transfer the patient immediately, and the ambulance was ready. I tried to convince the resident to administer furosemide before transferring the patient, but he feared administering a drug not approved by his superior. As the patient was loaded onto the ambulance, I reflected for a second on how different things would be if we were in the United States. We arrived at Mulago in record time, and I tried to get the intake doctors to understand what the problem was; however, they did not want to hear from the US doctor. I stared in frustration as they wasted valuable time. I wondered how long the patient would survive in respiratory distress with nothing being done. I called the patient's son and asked him to come to Mulago immediately. Miraculously, he had already been on his way. As I held the patient's hand, sure that he would die right then and there in a waiting area as nobody did anything, I saw the patient's son. I knew that he was a pharmacist, and I asked him to go to the pharmacy and buy furosemide and some syringes. In Uganda, one can buy any medication without a prescription. Luckily, the hospital pharmacy had the drug. We treated the patient, and in no time, his breathing had returned to normal.

I was jolted back to reality. He was dying, and I knew it. He had had many close calls. There was the time that he got the wrong blood during a blood transfusion. I informed the doctor on call as the blood was being administered that I thought the patient was getting a transfusion reaction because he had rigors. The physician on call suggested covering him in blankets, and I suggested stopping the infusion and administering steroids. The pack of blood showed that he was getting his blood type. The patient was typed and crossed again, and to our surprise, we got a different result. I went to the laboratory to perform a third, tie‐breaking cross match and was surprised to note that the reagents had passed their expiration date. However, I knew that these were small battles we were winning and that there was no winning the war.

I recognized that the challenges of practicing medicine in the developing world were many. I wondered how the patients of families with fewer resources survived. The answer was obvious: they didn't. I personally picked up blood when it was available from the blood bank and vividly remember walking from the blood bank at night to the private hospital with units of blood in each hand. Once we arrived at the hospital, I had to warm the blood to room temperature by holding it close to my own skin. Many tests that we perform routinely on a hospitalized patient in the United States are not available.

There was still the problem of breaking the news to the family. Despite everything that had been done and the many near misses that the patient had survived, he was still going to die. It turns out that the family was more intuitive than I thought. One day, the son came to me and asked how long his dad had. Not long, I said quietly. I thought about all that I could potentially do if I had the patient in the hospital at which I worked in the United States. Would it have made a difference? I do not know. It was impossible doctoring this patient, and I suspect doing it in a resource‐rich environment would not have made it any easier. You see this patient, perhaps the most important patient of my life, certainly a patient that I will never forget, was my father.

It had been 15 years since I had traveled to the United States for an education. I knew that my father was so incredibly proud of me. I think that he was the happiest I had ever seen him when he attended my graduation from medical school in Minnesota. I had been looking forward to this visit back home because it had been 3 years since I had last seen my family. I was somewhat concerned because my father had told me a week before I traveled that he was not feeling well. When I arrived, there seemed to be relief on my brother's face when he met me at the airport. We drove straight to the hospital, and along with the joy of seeing me, I could sense that my father was glad that I was home at this particular point in time. They had just received the diagnosis. He had leukemia, and they were glad that their doctor was home. They had particular faith in the daughter (sister) sent abroad for an education. Things would now be okay. Initially, I never got to choose the role of doctor that I played in the final chapter of my father's life. The decision was made for me out of my family's desperation to make sure that they had left no stone unturned to help my father, and I accepted it out of necessity. As my father became my father when I entered this world, I became his doctor when he was leaving it; there was never any question in my mind, as there never was in his. As it became clear that my father would not survive, I chose to continue the role of doctor. I have watched many patients die as a physician and have done my best to make sure that their passing is comfortable, peaceful, and dignified. The doctor could help this patient die, but the daughter could not watch her father go. When it was evident that he had only days to live and did not need this doctor or know his daughter, I flew back to the United States. Three days later my father died. I was not physically at his bedside, but my spirit was. I have no regrets. Although the head knows that he passed on, in my mind's eye, he is laughing and has a twinkle in his eye. I could not bear to see him without life. A piece of my heart is buried with him, and for this reason, I will never be out of Africa.

Acknowledgements

The author is indebted to J.B. Kisuule and seeks to honor his life of service. Thank you to Dr. Roy Ziegelstein for his help with this article.

Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
204-206
Page Number
204-206
Article Type
Display Headline
Out of Africa
Display Headline
Out of Africa
Sections
Article Source
Copyright © 2009 Society of Hospital Medicine
Disallow All Ads
Correspondence Location
Johns Hopkins Bayview Medical Center, Collaborative Inpatient Medicine Service, 5200 Eastern Avenue, MFL West, 6th Floor, Baltimore, MD 21224‐2780
Content Gating
Gated (full article locked unless allowed per User)
Gating Strategy
First Peek Free
Article PDF Media

Pediatric Hospitalists

Article Type
Changed
Sun, 05/28/2017 - 21:51
Display Headline
Pediatric hospitalists: Training, current practice, and career goals

There has been marked recent growth in the employment and utilization of both pediatric and adult hospitalists. Recent data demonstrate that approximately 25% of current pediatric hospitalist programs are less than 2 years old.1 Some have posited that this growth is due to increasing pressure from the public and payors to deliver cost‐effective and high‐quality care.2 However, little is known about the mechanisms by which those who deliver care in this framework are trained, nor the scope of clinical practice they provide.37 One study has shown that among those who direct pediatric hospitalist services there is a great degree of variability in the description of the roles, work patterns, and employment characteristics of hospitalists.1 That study provided only 1 perspective on the roles and career trajectories of those in the field. To better understand both the range and frequency of experiences, clinical and nonclinical roles, training, work expectations, and career plans, we conducted a national survey study of practicing pediatric hospitalists.

METHODS

Sample

We identified all 761 hospitals in the American Hospital Association (AHA)'s 2005 Annual Survey of Hospitals that reported to have both a hospitalist service (adult and/or pediatric) and pediatric beds. From these 761 hospitals, we selected a random sample of 213, stratified by:

  • Council of Teaching Hospital (COTH) designation

  • National Association of Children's Hospitals & Related Institutions (NACHRI) membership

  • Freestanding children's hospitals

  • Metropolitan Statistical Area (MSA) (urban versus rural location)

  • Hospital size (small: <250 total beds versus large: 250 total beds)

 

Some hospitals are included in more than 1 category. Thus, there is some overlap of hospitals in the analysis. Of these 213 hospitals, 97 were removed from the sample because they did not have at least 1 pediatric hospitalist. In a separate study, we surveyed hospitalist program directors at 112 of the remaining 116 hospitals from June through September 2006. These results have been published.1

Pediatric hospitalist program directors at these 112 participating hospitals were asked to provide the names of all practicing pediatric hospitalists in their respective programs. Ninety‐five of these program directors provided a list of hospitalists at their institutions, representing 85% of the hospitals in our previous study. A total of 530 practicing pediatric hospitalists were identified to us in this manner. Of these 530 hospitalists, 67% (N = 338) were from teaching hospitals, 71% (N = 374) were from children's hospitals, 43% (N = 230) were from freestanding children's hospitals, and 69% (N = 354) were from hospitals with 250 beds. These are not mutually exclusive categories.

Survey Instrument

We developed a structured questionnaire to be administered by mail. The survey contained 25 items and was designed to be completed in 10 minutes or less. The survey focused on exploring the characteristics of hospitalist clinical and nonclinical practice, service schedule, training, and career goals. The questionnaire was comprised of a mixture of fixed‐choice, Likert‐scale, and open‐ended questions.

Questionnaire Administration

In October 2006, the first mailing of questionnaires was sent via priority mail. The survey packet contained a personalized cover letter signed by the principal investigator (G.L.F.), the instrument, a business reply mail envelope, and a $5 bill as an incentive. Two additional mailings were sent to nonrespondents in November 2006 and January 2007.

Data Analysis

First, frequency distributions were calculated for all survey items. Next, comparisons were made between respondents indicating they held an academic appointment and those who did not. For the purposes of this analysis, academic pediatric hospitalists were defined as those respondents holding a full‐time or part‐time academic appointment. Nonacademic pediatric hospitalists were defined as respondents holding an adjunct or volunteer faculty position, or no academic appointment. Finally, chi‐square statistics were used to compare pediatric hospitalist responses by hospital demographics such as teaching status, children's hospital status, NACHRI freestanding hospital designation, and hospital bed size.

The study was approved by the University of Michigan Medical Institutional Review Board.

RESULTS

Response Rate

Of the initial 530 survey packets mailed, 18 were returned as undeliverable by the postal service and 431 physicians returned the survey. This yielded an overall response rate of 84%. Of the 431 respondents, 40 physicians were ineligible because they no longer provided inpatient care to children or did not consider themselves to be hospitalists. Thus, the final sample for analysis was 391.

Hospitalist Employment Characteristics

Demographics of Hospital Worksite

Of the 391 respondents, 61% (N = 237) were from teaching hospitals, 73% (N = 287) from children's hospitals, 47% (N = 182) from freestanding children's hospitals, and 66% (N = 258) from hospitals with more than 250 beds.

Physician Demographics

The mean age of respondents was 39 years and 59% were female. The majority were employed by a hospital or health system (56%), 20% were employed by a university, and 4% were employed by both. Eight percent reported employment by a general physician medical group, 7% were employed by a hospitalist‐only group, and 4% reported other sources of employment. Half of respondents (N = 196) reported holding a full‐time (40%) or part‐time (10%) academic appointment. Approximately half the respondents (N = 194) were considered nonacademic hospitalists.

More than half of respondents (54%; N = 211) had been practicing as hospitalists for at least 3 years. Reported time as a practicing hospitalist ranged from <1 year to 26 years, while the average length of time was 63 months (Table 1). These figures may be skewed because those hospitalists with higher turnover rates might have left their position during the period of time from when they were selected into the sample until the time of survey administration.

Length of Time Practicing as a Hospitalist
Length of Time as Hospitalist% (N)
  • NOTE: N = 389; values given are percent and number of hospitalists.

12 months13 (51)
13‐24 months18 (71)
25‐36 months14 (56)
37‐60 months17 (67)
>61 months37 (144)

Clinical Practice

Most respondents reported that the pediatric inpatient unit (94%) and inpatient consultation service (51%) were a part of their regular clinical assignment (Table 2). A majority did not provide service in the normal newborn nursery (58%), subspecialty inpatient service (52%), pediatric intensive care unit (ICU) (70%), neonatal ICU (77%), transports (85%), outpatient clinics (66%), or as part of an emergency response team (53%).

Hospitalist Service in Specific Clinical Settings
 Part of Regular Clinical Assignment % (N)Occasionally % (N)Never % (N)
  • NOTE: N = 390; values given are the percent and number of hospitalists responding yes to providing care in a specific setting.

  • Abbreviation: ICU, intensive care unit.

Pediatric inpatient unit94 (368)3 (13)2 (9)
Inpatient consultation service51 (199)40 (155)9 (35)
Normal newborn nursery29 (110)13 (50)58 (223)
Emergency department25 (95)28 (108)47 (178)
Subspecialty inpatient service25 (92)23 (86)52 (196)
Emergency response team23 (87)24 (91)53 (201)
Outpatient/outreach clinics18 (68)16 (61)66 (253)
Pediatric ICU14 (54)16 (59)70 (268)
Neonatal ICU12 (44)11 (42)77 (294)
Transports9 (33)6 (23)85 (319)

With regard to procedures, many (53%) respondents reported that they routinely perform or supervise lumbar punctures. Several services are never performed or never supervised by the majority of pediatric hospitalists, including infusion services (57%), peripherally inserted central catheter (PICC) placement (76%), central line placement (67%), and circumcision (85%).

Professional Roles and Parameters

Respondents reported that they participate in a variety of nonclinical activities. Ninety‐four percent of hospitalists were involved in education, and 45% reported having a leadership role in that area. The majority of respondents participated in quality improvement (QI) initiatives (84%) and practice guideline development (81%), with one‐quarter of hospitalists reporting a leadership role in each of these activities. Slightly more than half of respondents reported involvement in hospital administration (52%) and utilization review (55%) (Table 3).

Hospitalist Role in Nonclinical Settings
 ParticipationNo Involvement % (N)
Participation of Any Type % (N)Leadership Role % (N)
  • NOTE: N = 391; values given are the percent and number of hospitalists responding yes.

Education (students, house staff)94 (368)45 (177)6 (22)
Quality improvement initiatives84 (330)25 (99)16 (61)
Practice guideline development81 (313)26 (101)19 (74)
Utilization review55 (213)11 (41)45 (172)
Hospital administration52 (202)16 (60)48 (184)

On average, hospitalists reported spending 61% of their time providing inpatient care (excluding clinical teaching) and 16% of their time providing clinical teaching or supervising residents. More than one‐third of respondents (38%) spent more than 75% of their time providing direct inpatient care. Research (3%), administrative duties (8%), and nonclinical teaching (3%) were reported to be a small part of hospitalist professional time.

Pediatric Hospitalist Service Schedule

The majority of respondents reported that their assigned clinical schedule was a combination of shift and call (61%).

When on service, over half of responding pediatric hospitalists (58%) reported that they spend 40 to 60 hours onsite per week. Less than one‐fifth of respondents (19%) reported that they provide <40 hours of onsite coverage when on service. Most (97%) provide some type of night coverage, including taking calls from home or providing onsite coverage.

Hospitalist Training and Continuing Education

Only 51 of the 391 respondents (13%) had received some type of fellowship training, mostly in general pediatrics or the pediatric subspecialties. Only 5 respondents had received fellowship training in hospital medicine.

Fifty‐eight percent of respondents reported that they had received no hospitalist‐specific training. One‐fifth reported that they received training through a workshop at a professional meeting, while fewer respondents had received hospitalist training though a continuing medical education (CME) course (16%) or a mentoring program (17%).

Respondents were asked to rate the adequacy of their respective training in preparing them for their work as hospitalists. The vast majority rated their training in general clinical skills (94%) and communication (85%) as fully adequate. However, respondents found their training for some of the nonclinical aspects of their positions to be deficient. Many respondents rated training for QI projects (38%) and hospital administrative duties (46%) as inadequate (Table 4).

Preferred Adequacy of Training in Preparation for Hospitalist Role
 Fully Adequate % (N)Somewhat Adequate % (N)Not Adequate % (N)NA % (N)
  • NOTE: N = 389; values given are the percent and number of hospitalists responding yes.

  • Abbreviation: NA, not applicable.

General clinical skills94 (367)5 (21)0 (0)0 (1)
Communication skills85 (330)14 (53)1 (5)0 (1)
Coordination of care73 (284)23 (89)4 (15)0 (1)
Clinical procedure experience67 (258)32 (123)1 (5)1 (2)
Teaching skills (resident and medical student teaching)64 (248)31 (120)3 (13)2 (8)
Attending newborn deliveries60 (233)18 (70)4 (14)19 (72)
Running resuscitation (codes)45 (173)46 (177)5 (21)5 (18)
Quality improvement projects14 (55)42 (162)38 (148)6 (22)
Hospital administrative duties10 (37)37 (144)46 (177)8 (31)

Survey respondents were asked to indicate the extent to which they agreed or disagreed with 3 statements regarding hospitalist training. The majority of respondents believed that hospitalists need training in QI methods (70%). However, most pediatric hospitalists (73%) did not believe that additional training beyond residency should be required. Only one‐third (36%) of respondents agreed that current CME offerings are adequate for their needs as a pediatric hospitalist.

Career Goals and Expectations

Respondents were asked to select 1 or more reasons why they became pediatric hospitalists. The top factors influencing respondents' decision to become a hospitalist were reported to be a preference for the inpatient setting (73%), clinical variety (72%), enjoyment of teaching in the inpatient setting (58%), and a flexible schedule (52%) (Table 5).

Factors Influencing Decision to Become a Hospitalist
Factor% (N)
  • NOTE: N = 390; values given are the percent and number of hospitalists responding yes.

Prefer inpatient setting73 (284)
Clinical variety72 (281)
Enjoy teaching in inpatient setting58 (225)
Flexible schedule52 (202)
Defined hours41 (161)
Attractive career opportunities21 (80)
Salary18 (70)
Unsure of long‐term career direction13 (51)
Other7 (28)
Needed short‐term employment4 (15)
Only position available3 (10)

The majority (85%) were satisfied with their position as a pediatric hospitalist, with 37% reporting that they were extremely satisfied. Over one‐half (61%) expected to remain a hospitalist for the duration of their career.

RESULTS BY ACADEMIC STATUS

Only significant differences between academic and nonacademic hospitalists are presented.

Clinical Practice by Academic Status

Nonacademic respondents were more likely than academic respondents to report regular service in the normal newborn nursery, pediatric ICU, neonatal ICU, transports, emergency department, and as part of an emergency response team. Academic respondents were more likely to report regular service in outpatient clinics. Nonacademic respondents were more likely than academic respondents to perform or supervise lumbar punctures, sedation services, PICC or central line insertions, and circumcisions (Table 6).

Hospitalist Roles in Clinical and Nonclinical Settings: Academic versus Nonacademic Hospitalists
 Academic* (N = 196)Nonacademic (N = 194)P Value
  • Academic: hospitalists who reported a full‐time or part‐time academic appointment. Values given are the percent of hospitalists responding yes.

  • Nonacademic: hospitalists who reported an adjunct or volunteer faculty position, or no academic appointment. Values given are the percent of hospitalists responding yes.

  • Only significant differences are presented (P < 0.05).

  • Abbreviations: ICU, intensive care unit; PICC, peripherally inserted central catheter.

Regularly provides service   
Normal newborn nursery16%42%<0.0001
Pediatric ICU9%20%0.0065
Neonatal ICU4%20%<0.0001
Transports3%15%<0.0001
Emergency department16%34%<0.0001
Emergency response team17%29%<0.0001
Outpatient clinic23%13%0.0168
Performs or supervises procedures   
Lumbar puncture84%92%0.0152
Sedation services50%64%0.0055
PICC insertion8%18%0.0031
Central line insertion11%23%0.0018
Circumcision5%16%0.0002
Holds leadership roles   
Education (student or house staff)63%27%<0.0001
Hospital administration21%10%<0.0001
Quality improvement initiatives33%18%0.0005

Professional Roles and Parameters by Academic Status

Responding academic pediatric hospitalists were twice as likely as nonacademic respondents to have a leadership role in the education of students and house staff and to hold a leadership position in hospital administration. The academic respondents were also more likely to report a leadership role in QI initiatives (Table 6).

Clinical and Educational Activities by Academic Status

Academic pediatric hospitalist respondents reported spending on average 52% of their time providing inpatient care (excluding teaching), in contrast to the nonacademic hospitalist respondents who reported 71% of their time was spent providing inpatient care (P < 0.0001). Academic respondents also reported that 19% of their time was spent providing inpatient teaching or supervising residents, compared to 12% of nonacademic respondents (P < 0.0001). Responding academic pediatric hospitalists reported spending a greater proportion of time participating in nonclinical teaching activities (5% versus 2%; P < 0.0001), administrative duties (11% versus 5%; P < 0.0001), and research (4% versus 1%; P < 0.0001) compared to the nonacademic respondents.

Nonacademic respondents were more likely than academic respondents to report no hospitalist‐specific training (64% versus 54%; P = 0.0324).

RESULTS BY HOSPITAL CHARACTERISTICS

For each hospital characteristic, only significant differences between dichotomized groups are presented.

Children's Hospitals versus Other Hospitals

Clinical Practice

Pediatric hospitalist respondents practicing in NACHRI hospitals were more likely to report that they provide regular service for general pediatric inpatients (98% versus 86%; P < 0.0001) as well as subspecialty inpatients (27% versus 17%; P = 0.044). Non‐NACHRI pediatric hospitalist respondents were twice as likely to report the provision of regular service in the normal newborn nursery (49% versus 22%; P < 0.0001), the neonatal ICU (21% versus 8%, P = 0.002), and the emergency department (38% versus 20%; P < 0.0001).

Among respondents, pediatric hospitalists who were not working at a children's hospital were more likely to report that they sometimes or routinely performed lumbar punctures (93% versus 85%; P = 0.037), infusion services (36% versus 21%; P = 0.003), and were twice as likely to perform circumcision (16% versus 8%; P = 0.041) compared to those working at children's hospitals.

Professional Roles and Parameters

Respondents working in children's hospitals were twice as likely to hold a leadership position in utilization review (12% versus 6%; P = 0.012), though respondents from non‐NACHRI hospitals were more likely to at least participate in utilization review (58% versus 40%; P = 0.004).

Hospitalist Training

Respondents from non‐NACHRI hospitals were more likely to report that they had received no hospitalist‐specific training (68% versus 56%; P = 0.029). Those at NACHRI hospitals were twice as likely to have received hospitalist training through a mentoring program (20% versus 9%; P = 0.009).

Freestanding versus Nonfreestanding Children's Hospitals

Clinical Practice

Pediatric hospitalist respondents employed at institutions that are not freestanding children's hospitals were more likely to report that they provided regular service in the normal newborn nursery (42% versus 14%; P < 0.0001), pediatric ICU (22% versus 5%), emergency department (32% versus 17%; P < 0.0001), and outpatient clinics (23% versus 12%; P = 0.0068). They were also more likely to perform or supervise sedation services (63% versus 50%; P = 0.0116), infusion services (32% versus 17%; P = 0.0006), PICC insertions (19% versus 6%; P = 0.0002), central line insertions (23% versus 11%; P = 0.0024), and circumcisions (16% versus 3%; P < 0.0001).

Professional Roles and Parameters

Among respondents, pediatric hospitalists employed by nonfreestanding children's hospitals were more likely to report participation in utilization review (51% versus 38%; P = 0.02).

Hospital Size

Clinical Practice

Pediatric hospitalist respondents working at large hospitals were twice as likely to report that they regularly provided service in the pediatric ICU (18% versus 7%; P = 0.0072) and were more likely to regularly perform circumcisions (13% versus 5%; P = 0.0069). Respondents from small hospitals were more likely to provide regular service in the neonatal ICU (20% versus 7%; P = 0.0013).

COTH Status: Teaching versus Nonteaching Hospitals

Clinical Practice

Among survey respondents, pediatric hospitalists employed by COTH hospitals were more likely to provide regular service in the neonatal ICU, compared to their peers in nonteaching hospitals (15% versus 6%; P = 0.0109). Those employed by non‐COTH hospitals were more likely to provide service in subspecialty inpatient service (38% versus 16%; P < 0.0001), transports (14% versus 6%; P = 0.0227), inpatient consultation (61% versus 45%; P = 0.0086), and the emergency response team (29% versus 19%; P = 0.0021).

Professional Roles and Parameters

Respondents from COTH hospitals were more likely to have no involvement in utilization review, compared to their peers at non‐COTH hospitals (49% versus 37%; P = 0.0220).

DISCUSSION

This study provides the most comprehensive information available regarding the clinical and nonclinical roles, training, work expectations, and career plans of pediatric hospitalists. Among the most important of our findings is the distribution of the length of time that pediatric hospitalists had served in their roles. While over one‐third (37%) reported having been practicing as hospitalists for over 5 years, 45% of our respondents had been in practice for fewer than 3 years. This is consistent with both the perceptions of rapid growth of the field and with significant turnover of hospitalists.1, 8 It is important to note that our findings may actually overestimate the proportion of hospitalists with longer durations of employment as our sampling strategy would have been less likely to include those who left the field within the first 12 to 18 months of practice. Nevertheless, over half (61%) of our respondents expected to remain a hospitalist for the duration of their career and few reported choosing to become a hospitalist as a short‐term employment option. This finding has important implications for the future stability of the hospitalist workforce and the potential development of specific expertise among this cadre of clinicians.6

The demographic profile of pediatric hospitalists was also consistent with these findings. The mean age of 39 years for our respondents is indicative of a significant proportion of this group of physicians recently having completed their residency training. Further, the gender distribution approximates that of current pediatric residency graduates, thus indicating that that this is not a clinical choice for which there would be a skewed distribution as is the case in some pediatric subspecialties.9

Our findings were similar to the 2004 Ottolini et al.10 findings on the roles of pediatric hospitalists. Respondents in our study reported spending less time providing inpatient care (61% versus 75%), providing clinical teaching or supervising residents (16% versus 26%), performing administrative duties (8% versus 19%), and conducting research (3% versus 9%) compared with the respondents in the Ottolini et al.10 survey.

At this point in time, fewer than half of our respondents reported any hospitalist‐specific training, including workshops at professional meetings or CME coursework. As there are a paucity of fellowships offering postresidency training in pediatric hospital medicine, and most of the existing programs are newly established, few in practice have completed such programs.11 In addition, most respondents reported that current CME offerings do not meet their needs, and that they could have used additional QI training to prepare them for their role as pediatric hospitalists. However, almost three‐quarters of respondents (73%) do not believe any additional training beyond residency should be required. As such, it is unclear if a defined, unique body of knowledge specific to hospitalists is either needed or desired by those currently in the field.

Although there are a broad range of potential clinical roles within hospital medicine, and this clinical variety influenced most respondents' decisions to become hospitalists, the current scope of an individual hospitalist tends to become somewhat focused.12, 13 While we found almost all provided service on the pediatric inpatient unit, many fewer provided inpatient consultation and normal newborn care, or were involved in interhospital transport or as part of an emergency response team. There is also wide variation in the types of procedures performed or supervised by hospitalists at different institutions. More than half never perform or supervise infusion services, PICC or central line placement, or circumcision. The variation seen among hospitalists practicing in different hospital settings likely is a result, at least in part, of different needs in teaching hospitals for both service and for clinical experience of trainees. For example, our results demonstrate that pediatric hospitalists in nonteaching and non‐children's hospitals are more likely to have a broader scope of clinical care provision. Another potential issue is that some hospitalists may be employed by institutions which have no pediatric ICU, neonatal ICU, or other specialty unit. As such, these hospitalists would not have the opportunity to work in such settings.

Further, those without academic appointments are also more likely to have expanded clinical roles compared with their academic counterparts. This may be due to the fact that there is likely a greater number of subspecialty‐trained pediatric providers in academic centers and thus the need for hospitalists to cover specific services or perform specific procedures is lessened. There may also be a desire to prevent competition among care providers within the same institution. In contrast, hospitalists with academic appointments are more likely (though still uncommonly) to have taken leadership roles in hospital administration and QI initiatives. Thus, the nature of their efforts appears to expand into nonclinical delivery areas.

Clearly, hospitalists report they have assumed a significant role in the clinical teaching of trainees at all levels, with 94% of our respondents maintaining at least some involvement in education. On average, they spend 16% of their time in educational efforts. However, there are few data on the impact of their work in this area.5, 13 Studies in pediatrics to date have been limited to a few institutions,3, 5 and have not addressed the issue from the perspective of residency program directors or those who are in charge of inpatient curricula.

This study, like the majority of studies related to pediatric hospitalists, is hampered by the difficulty of identifying pediatric hospitalists. Rather than utilizing a hospital medicine membership list, which would be potentially biased by self‐selection, we attempted to obtain a more representative sample through utilization of the AHA database.

CONCLUSIONS

Findings from this study provide an additional perspective regarding pediatric hospitalists to add to our previous study of hospitalist program directors.1 However, the field is currently a moving target. Our data demonstrate that there is significant flux in the hospitalist workforce, uncertainty regarding turnover, and variation in the roles of these professionals in their clinical and nonclinical work environment. Moreover, additional studies of the educational impact of hospitalists on residency and medical student education are needed. Questions regarding the nature and degree of resident autonomy and experience conducting procedures in the hospitalist environment have been raised. These must be assessed through studies of residency program directors, their expectations of residents, and the curricula they have developed.

As with any new phenomenon, it will take time to understand the impact of hospitalists in a variety of domains. Additional research will be helpful in following the development of this field and the manner in which it will interface with existing medical practice and educational programs.

References
  1. Freed GL,Brzoznowski KF,Neighbors K,Lakhani I; The Research Advisory Committee of the American Board of Pediatrics.Characteristics of the pediatric hospitalist workforce: its roles and work environment.Pediatrics.2007;120:3339.
  2. Wachter RM.The evolution of the hospitalist model in the United States.Med Clin North Am.2002;86:687706.
  3. Freed GL,Uren RL.Hospitalists in children's hospitals: what we know now and what we need to know.J Pediatr.2006;148:296299.
  4. Flanders SA,Wachter RM.Hospitalists: the new model of inpatient medical care in the United States.Eur J Intern Med.2003;14:6570.
  5. Landrigan CP,Muret‐Wagstaff S,Chiang VW,Nigrin DJ,Goldman DA,Finklestein JA.Effect of a pediatric hospitalist system on housestaff education and experience.Arch Pediatr Adolesc Med.2002;156:877883.
  6. Plauth WH,Pantilat SZ,Wachter RM,Fenton CL.Hospitalists' perceptions of their residency training needs: results of a national survey.Am J Med.2001;111:247254.
  7. Srivastava R,Landrigan C,Gidwani P,Harary OH,Muret‐Wagstaff S,Homer CJ.Pediatric hospitalists in Canada and the United States: a survey of pediatric academic department chairs.Ambul Pediatr.2001;1:338339.
  8. Wachter RM.Hospitalists in the United States: mission accomplished or work in progress?N Engl J Med.2004;350:19351936.
  9. Althouse LA,Stockman JA.Pediatric workforce: a look at general pediatrics data from the American Board of Pediatrics.J Pediatr.2006;148:166169.
  10. Ottolini MC,Landrigan CP,Chiang VW,Stucky ER,PRIS survey: pediatric hospitalist roles and training needs [Abstr].Pediatr Res.2004;55:360A.
  11. Ranji SR,Rosenman DJ,Amin AN,Kripalani S.Hospital medicine fellowships: works in progress.Am J Med.2006;119:1.e11.e7.
  12. O'Leary KJ,Liebovitz DM,Baker DW.How hospitalists spend their time: insights on efficiency and safety.J Hosp Med.2006;1:8893.
  13. Carlson DW,Fentzke KM,Dawson JG.Pediatric hospitalists fill varied roles in the care of newborns.Pediatr Ann.2003;32:802810.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
179-186
Legacy Keywords
academic appointment, career trajectory, clinical practice, employment characteristics, job satisfaction
Sections
Article PDF
Article PDF

There has been marked recent growth in the employment and utilization of both pediatric and adult hospitalists. Recent data demonstrate that approximately 25% of current pediatric hospitalist programs are less than 2 years old.1 Some have posited that this growth is due to increasing pressure from the public and payors to deliver cost‐effective and high‐quality care.2 However, little is known about the mechanisms by which those who deliver care in this framework are trained, nor the scope of clinical practice they provide.37 One study has shown that among those who direct pediatric hospitalist services there is a great degree of variability in the description of the roles, work patterns, and employment characteristics of hospitalists.1 That study provided only 1 perspective on the roles and career trajectories of those in the field. To better understand both the range and frequency of experiences, clinical and nonclinical roles, training, work expectations, and career plans, we conducted a national survey study of practicing pediatric hospitalists.

METHODS

Sample

We identified all 761 hospitals in the American Hospital Association (AHA)'s 2005 Annual Survey of Hospitals that reported to have both a hospitalist service (adult and/or pediatric) and pediatric beds. From these 761 hospitals, we selected a random sample of 213, stratified by:

  • Council of Teaching Hospital (COTH) designation

  • National Association of Children's Hospitals & Related Institutions (NACHRI) membership

  • Freestanding children's hospitals

  • Metropolitan Statistical Area (MSA) (urban versus rural location)

  • Hospital size (small: <250 total beds versus large: 250 total beds)

 

Some hospitals are included in more than 1 category. Thus, there is some overlap of hospitals in the analysis. Of these 213 hospitals, 97 were removed from the sample because they did not have at least 1 pediatric hospitalist. In a separate study, we surveyed hospitalist program directors at 112 of the remaining 116 hospitals from June through September 2006. These results have been published.1

Pediatric hospitalist program directors at these 112 participating hospitals were asked to provide the names of all practicing pediatric hospitalists in their respective programs. Ninety‐five of these program directors provided a list of hospitalists at their institutions, representing 85% of the hospitals in our previous study. A total of 530 practicing pediatric hospitalists were identified to us in this manner. Of these 530 hospitalists, 67% (N = 338) were from teaching hospitals, 71% (N = 374) were from children's hospitals, 43% (N = 230) were from freestanding children's hospitals, and 69% (N = 354) were from hospitals with 250 beds. These are not mutually exclusive categories.

Survey Instrument

We developed a structured questionnaire to be administered by mail. The survey contained 25 items and was designed to be completed in 10 minutes or less. The survey focused on exploring the characteristics of hospitalist clinical and nonclinical practice, service schedule, training, and career goals. The questionnaire was comprised of a mixture of fixed‐choice, Likert‐scale, and open‐ended questions.

Questionnaire Administration

In October 2006, the first mailing of questionnaires was sent via priority mail. The survey packet contained a personalized cover letter signed by the principal investigator (G.L.F.), the instrument, a business reply mail envelope, and a $5 bill as an incentive. Two additional mailings were sent to nonrespondents in November 2006 and January 2007.

Data Analysis

First, frequency distributions were calculated for all survey items. Next, comparisons were made between respondents indicating they held an academic appointment and those who did not. For the purposes of this analysis, academic pediatric hospitalists were defined as those respondents holding a full‐time or part‐time academic appointment. Nonacademic pediatric hospitalists were defined as respondents holding an adjunct or volunteer faculty position, or no academic appointment. Finally, chi‐square statistics were used to compare pediatric hospitalist responses by hospital demographics such as teaching status, children's hospital status, NACHRI freestanding hospital designation, and hospital bed size.

The study was approved by the University of Michigan Medical Institutional Review Board.

RESULTS

Response Rate

Of the initial 530 survey packets mailed, 18 were returned as undeliverable by the postal service and 431 physicians returned the survey. This yielded an overall response rate of 84%. Of the 431 respondents, 40 physicians were ineligible because they no longer provided inpatient care to children or did not consider themselves to be hospitalists. Thus, the final sample for analysis was 391.

Hospitalist Employment Characteristics

Demographics of Hospital Worksite

Of the 391 respondents, 61% (N = 237) were from teaching hospitals, 73% (N = 287) from children's hospitals, 47% (N = 182) from freestanding children's hospitals, and 66% (N = 258) from hospitals with more than 250 beds.

Physician Demographics

The mean age of respondents was 39 years and 59% were female. The majority were employed by a hospital or health system (56%), 20% were employed by a university, and 4% were employed by both. Eight percent reported employment by a general physician medical group, 7% were employed by a hospitalist‐only group, and 4% reported other sources of employment. Half of respondents (N = 196) reported holding a full‐time (40%) or part‐time (10%) academic appointment. Approximately half the respondents (N = 194) were considered nonacademic hospitalists.

More than half of respondents (54%; N = 211) had been practicing as hospitalists for at least 3 years. Reported time as a practicing hospitalist ranged from <1 year to 26 years, while the average length of time was 63 months (Table 1). These figures may be skewed because those hospitalists with higher turnover rates might have left their position during the period of time from when they were selected into the sample until the time of survey administration.

Length of Time Practicing as a Hospitalist
Length of Time as Hospitalist% (N)
  • NOTE: N = 389; values given are percent and number of hospitalists.

12 months13 (51)
13‐24 months18 (71)
25‐36 months14 (56)
37‐60 months17 (67)
>61 months37 (144)

Clinical Practice

Most respondents reported that the pediatric inpatient unit (94%) and inpatient consultation service (51%) were a part of their regular clinical assignment (Table 2). A majority did not provide service in the normal newborn nursery (58%), subspecialty inpatient service (52%), pediatric intensive care unit (ICU) (70%), neonatal ICU (77%), transports (85%), outpatient clinics (66%), or as part of an emergency response team (53%).

Hospitalist Service in Specific Clinical Settings
 Part of Regular Clinical Assignment % (N)Occasionally % (N)Never % (N)
  • NOTE: N = 390; values given are the percent and number of hospitalists responding yes to providing care in a specific setting.

  • Abbreviation: ICU, intensive care unit.

Pediatric inpatient unit94 (368)3 (13)2 (9)
Inpatient consultation service51 (199)40 (155)9 (35)
Normal newborn nursery29 (110)13 (50)58 (223)
Emergency department25 (95)28 (108)47 (178)
Subspecialty inpatient service25 (92)23 (86)52 (196)
Emergency response team23 (87)24 (91)53 (201)
Outpatient/outreach clinics18 (68)16 (61)66 (253)
Pediatric ICU14 (54)16 (59)70 (268)
Neonatal ICU12 (44)11 (42)77 (294)
Transports9 (33)6 (23)85 (319)

With regard to procedures, many (53%) respondents reported that they routinely perform or supervise lumbar punctures. Several services are never performed or never supervised by the majority of pediatric hospitalists, including infusion services (57%), peripherally inserted central catheter (PICC) placement (76%), central line placement (67%), and circumcision (85%).

Professional Roles and Parameters

Respondents reported that they participate in a variety of nonclinical activities. Ninety‐four percent of hospitalists were involved in education, and 45% reported having a leadership role in that area. The majority of respondents participated in quality improvement (QI) initiatives (84%) and practice guideline development (81%), with one‐quarter of hospitalists reporting a leadership role in each of these activities. Slightly more than half of respondents reported involvement in hospital administration (52%) and utilization review (55%) (Table 3).

Hospitalist Role in Nonclinical Settings
 ParticipationNo Involvement % (N)
Participation of Any Type % (N)Leadership Role % (N)
  • NOTE: N = 391; values given are the percent and number of hospitalists responding yes.

Education (students, house staff)94 (368)45 (177)6 (22)
Quality improvement initiatives84 (330)25 (99)16 (61)
Practice guideline development81 (313)26 (101)19 (74)
Utilization review55 (213)11 (41)45 (172)
Hospital administration52 (202)16 (60)48 (184)

On average, hospitalists reported spending 61% of their time providing inpatient care (excluding clinical teaching) and 16% of their time providing clinical teaching or supervising residents. More than one‐third of respondents (38%) spent more than 75% of their time providing direct inpatient care. Research (3%), administrative duties (8%), and nonclinical teaching (3%) were reported to be a small part of hospitalist professional time.

Pediatric Hospitalist Service Schedule

The majority of respondents reported that their assigned clinical schedule was a combination of shift and call (61%).

When on service, over half of responding pediatric hospitalists (58%) reported that they spend 40 to 60 hours onsite per week. Less than one‐fifth of respondents (19%) reported that they provide <40 hours of onsite coverage when on service. Most (97%) provide some type of night coverage, including taking calls from home or providing onsite coverage.

Hospitalist Training and Continuing Education

Only 51 of the 391 respondents (13%) had received some type of fellowship training, mostly in general pediatrics or the pediatric subspecialties. Only 5 respondents had received fellowship training in hospital medicine.

Fifty‐eight percent of respondents reported that they had received no hospitalist‐specific training. One‐fifth reported that they received training through a workshop at a professional meeting, while fewer respondents had received hospitalist training though a continuing medical education (CME) course (16%) or a mentoring program (17%).

Respondents were asked to rate the adequacy of their respective training in preparing them for their work as hospitalists. The vast majority rated their training in general clinical skills (94%) and communication (85%) as fully adequate. However, respondents found their training for some of the nonclinical aspects of their positions to be deficient. Many respondents rated training for QI projects (38%) and hospital administrative duties (46%) as inadequate (Table 4).

Preferred Adequacy of Training in Preparation for Hospitalist Role
 Fully Adequate % (N)Somewhat Adequate % (N)Not Adequate % (N)NA % (N)
  • NOTE: N = 389; values given are the percent and number of hospitalists responding yes.

  • Abbreviation: NA, not applicable.

General clinical skills94 (367)5 (21)0 (0)0 (1)
Communication skills85 (330)14 (53)1 (5)0 (1)
Coordination of care73 (284)23 (89)4 (15)0 (1)
Clinical procedure experience67 (258)32 (123)1 (5)1 (2)
Teaching skills (resident and medical student teaching)64 (248)31 (120)3 (13)2 (8)
Attending newborn deliveries60 (233)18 (70)4 (14)19 (72)
Running resuscitation (codes)45 (173)46 (177)5 (21)5 (18)
Quality improvement projects14 (55)42 (162)38 (148)6 (22)
Hospital administrative duties10 (37)37 (144)46 (177)8 (31)

Survey respondents were asked to indicate the extent to which they agreed or disagreed with 3 statements regarding hospitalist training. The majority of respondents believed that hospitalists need training in QI methods (70%). However, most pediatric hospitalists (73%) did not believe that additional training beyond residency should be required. Only one‐third (36%) of respondents agreed that current CME offerings are adequate for their needs as a pediatric hospitalist.

Career Goals and Expectations

Respondents were asked to select 1 or more reasons why they became pediatric hospitalists. The top factors influencing respondents' decision to become a hospitalist were reported to be a preference for the inpatient setting (73%), clinical variety (72%), enjoyment of teaching in the inpatient setting (58%), and a flexible schedule (52%) (Table 5).

Factors Influencing Decision to Become a Hospitalist
Factor% (N)
  • NOTE: N = 390; values given are the percent and number of hospitalists responding yes.

Prefer inpatient setting73 (284)
Clinical variety72 (281)
Enjoy teaching in inpatient setting58 (225)
Flexible schedule52 (202)
Defined hours41 (161)
Attractive career opportunities21 (80)
Salary18 (70)
Unsure of long‐term career direction13 (51)
Other7 (28)
Needed short‐term employment4 (15)
Only position available3 (10)

The majority (85%) were satisfied with their position as a pediatric hospitalist, with 37% reporting that they were extremely satisfied. Over one‐half (61%) expected to remain a hospitalist for the duration of their career.

RESULTS BY ACADEMIC STATUS

Only significant differences between academic and nonacademic hospitalists are presented.

Clinical Practice by Academic Status

Nonacademic respondents were more likely than academic respondents to report regular service in the normal newborn nursery, pediatric ICU, neonatal ICU, transports, emergency department, and as part of an emergency response team. Academic respondents were more likely to report regular service in outpatient clinics. Nonacademic respondents were more likely than academic respondents to perform or supervise lumbar punctures, sedation services, PICC or central line insertions, and circumcisions (Table 6).

Hospitalist Roles in Clinical and Nonclinical Settings: Academic versus Nonacademic Hospitalists
 Academic* (N = 196)Nonacademic (N = 194)P Value
  • Academic: hospitalists who reported a full‐time or part‐time academic appointment. Values given are the percent of hospitalists responding yes.

  • Nonacademic: hospitalists who reported an adjunct or volunteer faculty position, or no academic appointment. Values given are the percent of hospitalists responding yes.

  • Only significant differences are presented (P < 0.05).

  • Abbreviations: ICU, intensive care unit; PICC, peripherally inserted central catheter.

Regularly provides service   
Normal newborn nursery16%42%<0.0001
Pediatric ICU9%20%0.0065
Neonatal ICU4%20%<0.0001
Transports3%15%<0.0001
Emergency department16%34%<0.0001
Emergency response team17%29%<0.0001
Outpatient clinic23%13%0.0168
Performs or supervises procedures   
Lumbar puncture84%92%0.0152
Sedation services50%64%0.0055
PICC insertion8%18%0.0031
Central line insertion11%23%0.0018
Circumcision5%16%0.0002
Holds leadership roles   
Education (student or house staff)63%27%<0.0001
Hospital administration21%10%<0.0001
Quality improvement initiatives33%18%0.0005

Professional Roles and Parameters by Academic Status

Responding academic pediatric hospitalists were twice as likely as nonacademic respondents to have a leadership role in the education of students and house staff and to hold a leadership position in hospital administration. The academic respondents were also more likely to report a leadership role in QI initiatives (Table 6).

Clinical and Educational Activities by Academic Status

Academic pediatric hospitalist respondents reported spending on average 52% of their time providing inpatient care (excluding teaching), in contrast to the nonacademic hospitalist respondents who reported 71% of their time was spent providing inpatient care (P < 0.0001). Academic respondents also reported that 19% of their time was spent providing inpatient teaching or supervising residents, compared to 12% of nonacademic respondents (P < 0.0001). Responding academic pediatric hospitalists reported spending a greater proportion of time participating in nonclinical teaching activities (5% versus 2%; P < 0.0001), administrative duties (11% versus 5%; P < 0.0001), and research (4% versus 1%; P < 0.0001) compared to the nonacademic respondents.

Nonacademic respondents were more likely than academic respondents to report no hospitalist‐specific training (64% versus 54%; P = 0.0324).

RESULTS BY HOSPITAL CHARACTERISTICS

For each hospital characteristic, only significant differences between dichotomized groups are presented.

Children's Hospitals versus Other Hospitals

Clinical Practice

Pediatric hospitalist respondents practicing in NACHRI hospitals were more likely to report that they provide regular service for general pediatric inpatients (98% versus 86%; P < 0.0001) as well as subspecialty inpatients (27% versus 17%; P = 0.044). Non‐NACHRI pediatric hospitalist respondents were twice as likely to report the provision of regular service in the normal newborn nursery (49% versus 22%; P < 0.0001), the neonatal ICU (21% versus 8%, P = 0.002), and the emergency department (38% versus 20%; P < 0.0001).

Among respondents, pediatric hospitalists who were not working at a children's hospital were more likely to report that they sometimes or routinely performed lumbar punctures (93% versus 85%; P = 0.037), infusion services (36% versus 21%; P = 0.003), and were twice as likely to perform circumcision (16% versus 8%; P = 0.041) compared to those working at children's hospitals.

Professional Roles and Parameters

Respondents working in children's hospitals were twice as likely to hold a leadership position in utilization review (12% versus 6%; P = 0.012), though respondents from non‐NACHRI hospitals were more likely to at least participate in utilization review (58% versus 40%; P = 0.004).

Hospitalist Training

Respondents from non‐NACHRI hospitals were more likely to report that they had received no hospitalist‐specific training (68% versus 56%; P = 0.029). Those at NACHRI hospitals were twice as likely to have received hospitalist training through a mentoring program (20% versus 9%; P = 0.009).

Freestanding versus Nonfreestanding Children's Hospitals

Clinical Practice

Pediatric hospitalist respondents employed at institutions that are not freestanding children's hospitals were more likely to report that they provided regular service in the normal newborn nursery (42% versus 14%; P < 0.0001), pediatric ICU (22% versus 5%), emergency department (32% versus 17%; P < 0.0001), and outpatient clinics (23% versus 12%; P = 0.0068). They were also more likely to perform or supervise sedation services (63% versus 50%; P = 0.0116), infusion services (32% versus 17%; P = 0.0006), PICC insertions (19% versus 6%; P = 0.0002), central line insertions (23% versus 11%; P = 0.0024), and circumcisions (16% versus 3%; P < 0.0001).

Professional Roles and Parameters

Among respondents, pediatric hospitalists employed by nonfreestanding children's hospitals were more likely to report participation in utilization review (51% versus 38%; P = 0.02).

Hospital Size

Clinical Practice

Pediatric hospitalist respondents working at large hospitals were twice as likely to report that they regularly provided service in the pediatric ICU (18% versus 7%; P = 0.0072) and were more likely to regularly perform circumcisions (13% versus 5%; P = 0.0069). Respondents from small hospitals were more likely to provide regular service in the neonatal ICU (20% versus 7%; P = 0.0013).

COTH Status: Teaching versus Nonteaching Hospitals

Clinical Practice

Among survey respondents, pediatric hospitalists employed by COTH hospitals were more likely to provide regular service in the neonatal ICU, compared to their peers in nonteaching hospitals (15% versus 6%; P = 0.0109). Those employed by non‐COTH hospitals were more likely to provide service in subspecialty inpatient service (38% versus 16%; P < 0.0001), transports (14% versus 6%; P = 0.0227), inpatient consultation (61% versus 45%; P = 0.0086), and the emergency response team (29% versus 19%; P = 0.0021).

Professional Roles and Parameters

Respondents from COTH hospitals were more likely to have no involvement in utilization review, compared to their peers at non‐COTH hospitals (49% versus 37%; P = 0.0220).

DISCUSSION

This study provides the most comprehensive information available regarding the clinical and nonclinical roles, training, work expectations, and career plans of pediatric hospitalists. Among the most important of our findings is the distribution of the length of time that pediatric hospitalists had served in their roles. While over one‐third (37%) reported having been practicing as hospitalists for over 5 years, 45% of our respondents had been in practice for fewer than 3 years. This is consistent with both the perceptions of rapid growth of the field and with significant turnover of hospitalists.1, 8 It is important to note that our findings may actually overestimate the proportion of hospitalists with longer durations of employment as our sampling strategy would have been less likely to include those who left the field within the first 12 to 18 months of practice. Nevertheless, over half (61%) of our respondents expected to remain a hospitalist for the duration of their career and few reported choosing to become a hospitalist as a short‐term employment option. This finding has important implications for the future stability of the hospitalist workforce and the potential development of specific expertise among this cadre of clinicians.6

The demographic profile of pediatric hospitalists was also consistent with these findings. The mean age of 39 years for our respondents is indicative of a significant proportion of this group of physicians recently having completed their residency training. Further, the gender distribution approximates that of current pediatric residency graduates, thus indicating that that this is not a clinical choice for which there would be a skewed distribution as is the case in some pediatric subspecialties.9

Our findings were similar to the 2004 Ottolini et al.10 findings on the roles of pediatric hospitalists. Respondents in our study reported spending less time providing inpatient care (61% versus 75%), providing clinical teaching or supervising residents (16% versus 26%), performing administrative duties (8% versus 19%), and conducting research (3% versus 9%) compared with the respondents in the Ottolini et al.10 survey.

At this point in time, fewer than half of our respondents reported any hospitalist‐specific training, including workshops at professional meetings or CME coursework. As there are a paucity of fellowships offering postresidency training in pediatric hospital medicine, and most of the existing programs are newly established, few in practice have completed such programs.11 In addition, most respondents reported that current CME offerings do not meet their needs, and that they could have used additional QI training to prepare them for their role as pediatric hospitalists. However, almost three‐quarters of respondents (73%) do not believe any additional training beyond residency should be required. As such, it is unclear if a defined, unique body of knowledge specific to hospitalists is either needed or desired by those currently in the field.

Although there are a broad range of potential clinical roles within hospital medicine, and this clinical variety influenced most respondents' decisions to become hospitalists, the current scope of an individual hospitalist tends to become somewhat focused.12, 13 While we found almost all provided service on the pediatric inpatient unit, many fewer provided inpatient consultation and normal newborn care, or were involved in interhospital transport or as part of an emergency response team. There is also wide variation in the types of procedures performed or supervised by hospitalists at different institutions. More than half never perform or supervise infusion services, PICC or central line placement, or circumcision. The variation seen among hospitalists practicing in different hospital settings likely is a result, at least in part, of different needs in teaching hospitals for both service and for clinical experience of trainees. For example, our results demonstrate that pediatric hospitalists in nonteaching and non‐children's hospitals are more likely to have a broader scope of clinical care provision. Another potential issue is that some hospitalists may be employed by institutions which have no pediatric ICU, neonatal ICU, or other specialty unit. As such, these hospitalists would not have the opportunity to work in such settings.

Further, those without academic appointments are also more likely to have expanded clinical roles compared with their academic counterparts. This may be due to the fact that there is likely a greater number of subspecialty‐trained pediatric providers in academic centers and thus the need for hospitalists to cover specific services or perform specific procedures is lessened. There may also be a desire to prevent competition among care providers within the same institution. In contrast, hospitalists with academic appointments are more likely (though still uncommonly) to have taken leadership roles in hospital administration and QI initiatives. Thus, the nature of their efforts appears to expand into nonclinical delivery areas.

Clearly, hospitalists report they have assumed a significant role in the clinical teaching of trainees at all levels, with 94% of our respondents maintaining at least some involvement in education. On average, they spend 16% of their time in educational efforts. However, there are few data on the impact of their work in this area.5, 13 Studies in pediatrics to date have been limited to a few institutions,3, 5 and have not addressed the issue from the perspective of residency program directors or those who are in charge of inpatient curricula.

This study, like the majority of studies related to pediatric hospitalists, is hampered by the difficulty of identifying pediatric hospitalists. Rather than utilizing a hospital medicine membership list, which would be potentially biased by self‐selection, we attempted to obtain a more representative sample through utilization of the AHA database.

CONCLUSIONS

Findings from this study provide an additional perspective regarding pediatric hospitalists to add to our previous study of hospitalist program directors.1 However, the field is currently a moving target. Our data demonstrate that there is significant flux in the hospitalist workforce, uncertainty regarding turnover, and variation in the roles of these professionals in their clinical and nonclinical work environment. Moreover, additional studies of the educational impact of hospitalists on residency and medical student education are needed. Questions regarding the nature and degree of resident autonomy and experience conducting procedures in the hospitalist environment have been raised. These must be assessed through studies of residency program directors, their expectations of residents, and the curricula they have developed.

As with any new phenomenon, it will take time to understand the impact of hospitalists in a variety of domains. Additional research will be helpful in following the development of this field and the manner in which it will interface with existing medical practice and educational programs.

There has been marked recent growth in the employment and utilization of both pediatric and adult hospitalists. Recent data demonstrate that approximately 25% of current pediatric hospitalist programs are less than 2 years old.1 Some have posited that this growth is due to increasing pressure from the public and payors to deliver cost‐effective and high‐quality care.2 However, little is known about the mechanisms by which those who deliver care in this framework are trained, nor the scope of clinical practice they provide.37 One study has shown that among those who direct pediatric hospitalist services there is a great degree of variability in the description of the roles, work patterns, and employment characteristics of hospitalists.1 That study provided only 1 perspective on the roles and career trajectories of those in the field. To better understand both the range and frequency of experiences, clinical and nonclinical roles, training, work expectations, and career plans, we conducted a national survey study of practicing pediatric hospitalists.

METHODS

Sample

We identified all 761 hospitals in the American Hospital Association (AHA)'s 2005 Annual Survey of Hospitals that reported to have both a hospitalist service (adult and/or pediatric) and pediatric beds. From these 761 hospitals, we selected a random sample of 213, stratified by:

  • Council of Teaching Hospital (COTH) designation

  • National Association of Children's Hospitals & Related Institutions (NACHRI) membership

  • Freestanding children's hospitals

  • Metropolitan Statistical Area (MSA) (urban versus rural location)

  • Hospital size (small: <250 total beds versus large: 250 total beds)

 

Some hospitals are included in more than 1 category. Thus, there is some overlap of hospitals in the analysis. Of these 213 hospitals, 97 were removed from the sample because they did not have at least 1 pediatric hospitalist. In a separate study, we surveyed hospitalist program directors at 112 of the remaining 116 hospitals from June through September 2006. These results have been published.1

Pediatric hospitalist program directors at these 112 participating hospitals were asked to provide the names of all practicing pediatric hospitalists in their respective programs. Ninety‐five of these program directors provided a list of hospitalists at their institutions, representing 85% of the hospitals in our previous study. A total of 530 practicing pediatric hospitalists were identified to us in this manner. Of these 530 hospitalists, 67% (N = 338) were from teaching hospitals, 71% (N = 374) were from children's hospitals, 43% (N = 230) were from freestanding children's hospitals, and 69% (N = 354) were from hospitals with 250 beds. These are not mutually exclusive categories.

Survey Instrument

We developed a structured questionnaire to be administered by mail. The survey contained 25 items and was designed to be completed in 10 minutes or less. The survey focused on exploring the characteristics of hospitalist clinical and nonclinical practice, service schedule, training, and career goals. The questionnaire was comprised of a mixture of fixed‐choice, Likert‐scale, and open‐ended questions.

Questionnaire Administration

In October 2006, the first mailing of questionnaires was sent via priority mail. The survey packet contained a personalized cover letter signed by the principal investigator (G.L.F.), the instrument, a business reply mail envelope, and a $5 bill as an incentive. Two additional mailings were sent to nonrespondents in November 2006 and January 2007.

Data Analysis

First, frequency distributions were calculated for all survey items. Next, comparisons were made between respondents indicating they held an academic appointment and those who did not. For the purposes of this analysis, academic pediatric hospitalists were defined as those respondents holding a full‐time or part‐time academic appointment. Nonacademic pediatric hospitalists were defined as respondents holding an adjunct or volunteer faculty position, or no academic appointment. Finally, chi‐square statistics were used to compare pediatric hospitalist responses by hospital demographics such as teaching status, children's hospital status, NACHRI freestanding hospital designation, and hospital bed size.

The study was approved by the University of Michigan Medical Institutional Review Board.

RESULTS

Response Rate

Of the initial 530 survey packets mailed, 18 were returned as undeliverable by the postal service and 431 physicians returned the survey. This yielded an overall response rate of 84%. Of the 431 respondents, 40 physicians were ineligible because they no longer provided inpatient care to children or did not consider themselves to be hospitalists. Thus, the final sample for analysis was 391.

Hospitalist Employment Characteristics

Demographics of Hospital Worksite

Of the 391 respondents, 61% (N = 237) were from teaching hospitals, 73% (N = 287) from children's hospitals, 47% (N = 182) from freestanding children's hospitals, and 66% (N = 258) from hospitals with more than 250 beds.

Physician Demographics

The mean age of respondents was 39 years and 59% were female. The majority were employed by a hospital or health system (56%), 20% were employed by a university, and 4% were employed by both. Eight percent reported employment by a general physician medical group, 7% were employed by a hospitalist‐only group, and 4% reported other sources of employment. Half of respondents (N = 196) reported holding a full‐time (40%) or part‐time (10%) academic appointment. Approximately half the respondents (N = 194) were considered nonacademic hospitalists.

More than half of respondents (54%; N = 211) had been practicing as hospitalists for at least 3 years. Reported time as a practicing hospitalist ranged from <1 year to 26 years, while the average length of time was 63 months (Table 1). These figures may be skewed because those hospitalists with higher turnover rates might have left their position during the period of time from when they were selected into the sample until the time of survey administration.

Length of Time Practicing as a Hospitalist
Length of Time as Hospitalist% (N)
  • NOTE: N = 389; values given are percent and number of hospitalists.

12 months13 (51)
13‐24 months18 (71)
25‐36 months14 (56)
37‐60 months17 (67)
>61 months37 (144)

Clinical Practice

Most respondents reported that the pediatric inpatient unit (94%) and inpatient consultation service (51%) were a part of their regular clinical assignment (Table 2). A majority did not provide service in the normal newborn nursery (58%), subspecialty inpatient service (52%), pediatric intensive care unit (ICU) (70%), neonatal ICU (77%), transports (85%), outpatient clinics (66%), or as part of an emergency response team (53%).

Hospitalist Service in Specific Clinical Settings
 Part of Regular Clinical Assignment % (N)Occasionally % (N)Never % (N)
  • NOTE: N = 390; values given are the percent and number of hospitalists responding yes to providing care in a specific setting.

  • Abbreviation: ICU, intensive care unit.

Pediatric inpatient unit94 (368)3 (13)2 (9)
Inpatient consultation service51 (199)40 (155)9 (35)
Normal newborn nursery29 (110)13 (50)58 (223)
Emergency department25 (95)28 (108)47 (178)
Subspecialty inpatient service25 (92)23 (86)52 (196)
Emergency response team23 (87)24 (91)53 (201)
Outpatient/outreach clinics18 (68)16 (61)66 (253)
Pediatric ICU14 (54)16 (59)70 (268)
Neonatal ICU12 (44)11 (42)77 (294)
Transports9 (33)6 (23)85 (319)

With regard to procedures, many (53%) respondents reported that they routinely perform or supervise lumbar punctures. Several services are never performed or never supervised by the majority of pediatric hospitalists, including infusion services (57%), peripherally inserted central catheter (PICC) placement (76%), central line placement (67%), and circumcision (85%).

Professional Roles and Parameters

Respondents reported that they participate in a variety of nonclinical activities. Ninety‐four percent of hospitalists were involved in education, and 45% reported having a leadership role in that area. The majority of respondents participated in quality improvement (QI) initiatives (84%) and practice guideline development (81%), with one‐quarter of hospitalists reporting a leadership role in each of these activities. Slightly more than half of respondents reported involvement in hospital administration (52%) and utilization review (55%) (Table 3).

Hospitalist Role in Nonclinical Settings
 ParticipationNo Involvement % (N)
Participation of Any Type % (N)Leadership Role % (N)
  • NOTE: N = 391; values given are the percent and number of hospitalists responding yes.

Education (students, house staff)94 (368)45 (177)6 (22)
Quality improvement initiatives84 (330)25 (99)16 (61)
Practice guideline development81 (313)26 (101)19 (74)
Utilization review55 (213)11 (41)45 (172)
Hospital administration52 (202)16 (60)48 (184)

On average, hospitalists reported spending 61% of their time providing inpatient care (excluding clinical teaching) and 16% of their time providing clinical teaching or supervising residents. More than one‐third of respondents (38%) spent more than 75% of their time providing direct inpatient care. Research (3%), administrative duties (8%), and nonclinical teaching (3%) were reported to be a small part of hospitalist professional time.

Pediatric Hospitalist Service Schedule

The majority of respondents reported that their assigned clinical schedule was a combination of shift and call (61%).

When on service, over half of responding pediatric hospitalists (58%) reported that they spend 40 to 60 hours onsite per week. Less than one‐fifth of respondents (19%) reported that they provide <40 hours of onsite coverage when on service. Most (97%) provide some type of night coverage, including taking calls from home or providing onsite coverage.

Hospitalist Training and Continuing Education

Only 51 of the 391 respondents (13%) had received some type of fellowship training, mostly in general pediatrics or the pediatric subspecialties. Only 5 respondents had received fellowship training in hospital medicine.

Fifty‐eight percent of respondents reported that they had received no hospitalist‐specific training. One‐fifth reported that they received training through a workshop at a professional meeting, while fewer respondents had received hospitalist training though a continuing medical education (CME) course (16%) or a mentoring program (17%).

Respondents were asked to rate the adequacy of their respective training in preparing them for their work as hospitalists. The vast majority rated their training in general clinical skills (94%) and communication (85%) as fully adequate. However, respondents found their training for some of the nonclinical aspects of their positions to be deficient. Many respondents rated training for QI projects (38%) and hospital administrative duties (46%) as inadequate (Table 4).

Preferred Adequacy of Training in Preparation for Hospitalist Role
 Fully Adequate % (N)Somewhat Adequate % (N)Not Adequate % (N)NA % (N)
  • NOTE: N = 389; values given are the percent and number of hospitalists responding yes.

  • Abbreviation: NA, not applicable.

General clinical skills94 (367)5 (21)0 (0)0 (1)
Communication skills85 (330)14 (53)1 (5)0 (1)
Coordination of care73 (284)23 (89)4 (15)0 (1)
Clinical procedure experience67 (258)32 (123)1 (5)1 (2)
Teaching skills (resident and medical student teaching)64 (248)31 (120)3 (13)2 (8)
Attending newborn deliveries60 (233)18 (70)4 (14)19 (72)
Running resuscitation (codes)45 (173)46 (177)5 (21)5 (18)
Quality improvement projects14 (55)42 (162)38 (148)6 (22)
Hospital administrative duties10 (37)37 (144)46 (177)8 (31)

Survey respondents were asked to indicate the extent to which they agreed or disagreed with 3 statements regarding hospitalist training. The majority of respondents believed that hospitalists need training in QI methods (70%). However, most pediatric hospitalists (73%) did not believe that additional training beyond residency should be required. Only one‐third (36%) of respondents agreed that current CME offerings are adequate for their needs as a pediatric hospitalist.

Career Goals and Expectations

Respondents were asked to select 1 or more reasons why they became pediatric hospitalists. The top factors influencing respondents' decision to become a hospitalist were reported to be a preference for the inpatient setting (73%), clinical variety (72%), enjoyment of teaching in the inpatient setting (58%), and a flexible schedule (52%) (Table 5).

Factors Influencing Decision to Become a Hospitalist
Factor% (N)
  • NOTE: N = 390; values given are the percent and number of hospitalists responding yes.

Prefer inpatient setting73 (284)
Clinical variety72 (281)
Enjoy teaching in inpatient setting58 (225)
Flexible schedule52 (202)
Defined hours41 (161)
Attractive career opportunities21 (80)
Salary18 (70)
Unsure of long‐term career direction13 (51)
Other7 (28)
Needed short‐term employment4 (15)
Only position available3 (10)

The majority (85%) were satisfied with their position as a pediatric hospitalist, with 37% reporting that they were extremely satisfied. Over one‐half (61%) expected to remain a hospitalist for the duration of their career.

RESULTS BY ACADEMIC STATUS

Only significant differences between academic and nonacademic hospitalists are presented.

Clinical Practice by Academic Status

Nonacademic respondents were more likely than academic respondents to report regular service in the normal newborn nursery, pediatric ICU, neonatal ICU, transports, emergency department, and as part of an emergency response team. Academic respondents were more likely to report regular service in outpatient clinics. Nonacademic respondents were more likely than academic respondents to perform or supervise lumbar punctures, sedation services, PICC or central line insertions, and circumcisions (Table 6).

Hospitalist Roles in Clinical and Nonclinical Settings: Academic versus Nonacademic Hospitalists
 Academic* (N = 196)Nonacademic (N = 194)P Value
  • Academic: hospitalists who reported a full‐time or part‐time academic appointment. Values given are the percent of hospitalists responding yes.

  • Nonacademic: hospitalists who reported an adjunct or volunteer faculty position, or no academic appointment. Values given are the percent of hospitalists responding yes.

  • Only significant differences are presented (P < 0.05).

  • Abbreviations: ICU, intensive care unit; PICC, peripherally inserted central catheter.

Regularly provides service   
Normal newborn nursery16%42%<0.0001
Pediatric ICU9%20%0.0065
Neonatal ICU4%20%<0.0001
Transports3%15%<0.0001
Emergency department16%34%<0.0001
Emergency response team17%29%<0.0001
Outpatient clinic23%13%0.0168
Performs or supervises procedures   
Lumbar puncture84%92%0.0152
Sedation services50%64%0.0055
PICC insertion8%18%0.0031
Central line insertion11%23%0.0018
Circumcision5%16%0.0002
Holds leadership roles   
Education (student or house staff)63%27%<0.0001
Hospital administration21%10%<0.0001
Quality improvement initiatives33%18%0.0005

Professional Roles and Parameters by Academic Status

Responding academic pediatric hospitalists were twice as likely as nonacademic respondents to have a leadership role in the education of students and house staff and to hold a leadership position in hospital administration. The academic respondents were also more likely to report a leadership role in QI initiatives (Table 6).

Clinical and Educational Activities by Academic Status

Academic pediatric hospitalist respondents reported spending on average 52% of their time providing inpatient care (excluding teaching), in contrast to the nonacademic hospitalist respondents who reported 71% of their time was spent providing inpatient care (P < 0.0001). Academic respondents also reported that 19% of their time was spent providing inpatient teaching or supervising residents, compared to 12% of nonacademic respondents (P < 0.0001). Responding academic pediatric hospitalists reported spending a greater proportion of time participating in nonclinical teaching activities (5% versus 2%; P < 0.0001), administrative duties (11% versus 5%; P < 0.0001), and research (4% versus 1%; P < 0.0001) compared to the nonacademic respondents.

Nonacademic respondents were more likely than academic respondents to report no hospitalist‐specific training (64% versus 54%; P = 0.0324).

RESULTS BY HOSPITAL CHARACTERISTICS

For each hospital characteristic, only significant differences between dichotomized groups are presented.

Children's Hospitals versus Other Hospitals

Clinical Practice

Pediatric hospitalist respondents practicing in NACHRI hospitals were more likely to report that they provide regular service for general pediatric inpatients (98% versus 86%; P < 0.0001) as well as subspecialty inpatients (27% versus 17%; P = 0.044). Non‐NACHRI pediatric hospitalist respondents were twice as likely to report the provision of regular service in the normal newborn nursery (49% versus 22%; P < 0.0001), the neonatal ICU (21% versus 8%, P = 0.002), and the emergency department (38% versus 20%; P < 0.0001).

Among respondents, pediatric hospitalists who were not working at a children's hospital were more likely to report that they sometimes or routinely performed lumbar punctures (93% versus 85%; P = 0.037), infusion services (36% versus 21%; P = 0.003), and were twice as likely to perform circumcision (16% versus 8%; P = 0.041) compared to those working at children's hospitals.

Professional Roles and Parameters

Respondents working in children's hospitals were twice as likely to hold a leadership position in utilization review (12% versus 6%; P = 0.012), though respondents from non‐NACHRI hospitals were more likely to at least participate in utilization review (58% versus 40%; P = 0.004).

Hospitalist Training

Respondents from non‐NACHRI hospitals were more likely to report that they had received no hospitalist‐specific training (68% versus 56%; P = 0.029). Those at NACHRI hospitals were twice as likely to have received hospitalist training through a mentoring program (20% versus 9%; P = 0.009).

Freestanding versus Nonfreestanding Children's Hospitals

Clinical Practice

Pediatric hospitalist respondents employed at institutions that are not freestanding children's hospitals were more likely to report that they provided regular service in the normal newborn nursery (42% versus 14%; P < 0.0001), pediatric ICU (22% versus 5%), emergency department (32% versus 17%; P < 0.0001), and outpatient clinics (23% versus 12%; P = 0.0068). They were also more likely to perform or supervise sedation services (63% versus 50%; P = 0.0116), infusion services (32% versus 17%; P = 0.0006), PICC insertions (19% versus 6%; P = 0.0002), central line insertions (23% versus 11%; P = 0.0024), and circumcisions (16% versus 3%; P < 0.0001).

Professional Roles and Parameters

Among respondents, pediatric hospitalists employed by nonfreestanding children's hospitals were more likely to report participation in utilization review (51% versus 38%; P = 0.02).

Hospital Size

Clinical Practice

Pediatric hospitalist respondents working at large hospitals were twice as likely to report that they regularly provided service in the pediatric ICU (18% versus 7%; P = 0.0072) and were more likely to regularly perform circumcisions (13% versus 5%; P = 0.0069). Respondents from small hospitals were more likely to provide regular service in the neonatal ICU (20% versus 7%; P = 0.0013).

COTH Status: Teaching versus Nonteaching Hospitals

Clinical Practice

Among survey respondents, pediatric hospitalists employed by COTH hospitals were more likely to provide regular service in the neonatal ICU, compared to their peers in nonteaching hospitals (15% versus 6%; P = 0.0109). Those employed by non‐COTH hospitals were more likely to provide service in subspecialty inpatient service (38% versus 16%; P < 0.0001), transports (14% versus 6%; P = 0.0227), inpatient consultation (61% versus 45%; P = 0.0086), and the emergency response team (29% versus 19%; P = 0.0021).

Professional Roles and Parameters

Respondents from COTH hospitals were more likely to have no involvement in utilization review, compared to their peers at non‐COTH hospitals (49% versus 37%; P = 0.0220).

DISCUSSION

This study provides the most comprehensive information available regarding the clinical and nonclinical roles, training, work expectations, and career plans of pediatric hospitalists. Among the most important of our findings is the distribution of the length of time that pediatric hospitalists had served in their roles. While over one‐third (37%) reported having been practicing as hospitalists for over 5 years, 45% of our respondents had been in practice for fewer than 3 years. This is consistent with both the perceptions of rapid growth of the field and with significant turnover of hospitalists.1, 8 It is important to note that our findings may actually overestimate the proportion of hospitalists with longer durations of employment as our sampling strategy would have been less likely to include those who left the field within the first 12 to 18 months of practice. Nevertheless, over half (61%) of our respondents expected to remain a hospitalist for the duration of their career and few reported choosing to become a hospitalist as a short‐term employment option. This finding has important implications for the future stability of the hospitalist workforce and the potential development of specific expertise among this cadre of clinicians.6

The demographic profile of pediatric hospitalists was also consistent with these findings. The mean age of 39 years for our respondents is indicative of a significant proportion of this group of physicians recently having completed their residency training. Further, the gender distribution approximates that of current pediatric residency graduates, thus indicating that that this is not a clinical choice for which there would be a skewed distribution as is the case in some pediatric subspecialties.9

Our findings were similar to the 2004 Ottolini et al.10 findings on the roles of pediatric hospitalists. Respondents in our study reported spending less time providing inpatient care (61% versus 75%), providing clinical teaching or supervising residents (16% versus 26%), performing administrative duties (8% versus 19%), and conducting research (3% versus 9%) compared with the respondents in the Ottolini et al.10 survey.

At this point in time, fewer than half of our respondents reported any hospitalist‐specific training, including workshops at professional meetings or CME coursework. As there are a paucity of fellowships offering postresidency training in pediatric hospital medicine, and most of the existing programs are newly established, few in practice have completed such programs.11 In addition, most respondents reported that current CME offerings do not meet their needs, and that they could have used additional QI training to prepare them for their role as pediatric hospitalists. However, almost three‐quarters of respondents (73%) do not believe any additional training beyond residency should be required. As such, it is unclear if a defined, unique body of knowledge specific to hospitalists is either needed or desired by those currently in the field.

Although there are a broad range of potential clinical roles within hospital medicine, and this clinical variety influenced most respondents' decisions to become hospitalists, the current scope of an individual hospitalist tends to become somewhat focused.12, 13 While we found almost all provided service on the pediatric inpatient unit, many fewer provided inpatient consultation and normal newborn care, or were involved in interhospital transport or as part of an emergency response team. There is also wide variation in the types of procedures performed or supervised by hospitalists at different institutions. More than half never perform or supervise infusion services, PICC or central line placement, or circumcision. The variation seen among hospitalists practicing in different hospital settings likely is a result, at least in part, of different needs in teaching hospitals for both service and for clinical experience of trainees. For example, our results demonstrate that pediatric hospitalists in nonteaching and non‐children's hospitals are more likely to have a broader scope of clinical care provision. Another potential issue is that some hospitalists may be employed by institutions which have no pediatric ICU, neonatal ICU, or other specialty unit. As such, these hospitalists would not have the opportunity to work in such settings.

Further, those without academic appointments are also more likely to have expanded clinical roles compared with their academic counterparts. This may be due to the fact that there is likely a greater number of subspecialty‐trained pediatric providers in academic centers and thus the need for hospitalists to cover specific services or perform specific procedures is lessened. There may also be a desire to prevent competition among care providers within the same institution. In contrast, hospitalists with academic appointments are more likely (though still uncommonly) to have taken leadership roles in hospital administration and QI initiatives. Thus, the nature of their efforts appears to expand into nonclinical delivery areas.

Clearly, hospitalists report they have assumed a significant role in the clinical teaching of trainees at all levels, with 94% of our respondents maintaining at least some involvement in education. On average, they spend 16% of their time in educational efforts. However, there are few data on the impact of their work in this area.5, 13 Studies in pediatrics to date have been limited to a few institutions,3, 5 and have not addressed the issue from the perspective of residency program directors or those who are in charge of inpatient curricula.

This study, like the majority of studies related to pediatric hospitalists, is hampered by the difficulty of identifying pediatric hospitalists. Rather than utilizing a hospital medicine membership list, which would be potentially biased by self‐selection, we attempted to obtain a more representative sample through utilization of the AHA database.

CONCLUSIONS

Findings from this study provide an additional perspective regarding pediatric hospitalists to add to our previous study of hospitalist program directors.1 However, the field is currently a moving target. Our data demonstrate that there is significant flux in the hospitalist workforce, uncertainty regarding turnover, and variation in the roles of these professionals in their clinical and nonclinical work environment. Moreover, additional studies of the educational impact of hospitalists on residency and medical student education are needed. Questions regarding the nature and degree of resident autonomy and experience conducting procedures in the hospitalist environment have been raised. These must be assessed through studies of residency program directors, their expectations of residents, and the curricula they have developed.

As with any new phenomenon, it will take time to understand the impact of hospitalists in a variety of domains. Additional research will be helpful in following the development of this field and the manner in which it will interface with existing medical practice and educational programs.

References
  1. Freed GL,Brzoznowski KF,Neighbors K,Lakhani I; The Research Advisory Committee of the American Board of Pediatrics.Characteristics of the pediatric hospitalist workforce: its roles and work environment.Pediatrics.2007;120:3339.
  2. Wachter RM.The evolution of the hospitalist model in the United States.Med Clin North Am.2002;86:687706.
  3. Freed GL,Uren RL.Hospitalists in children's hospitals: what we know now and what we need to know.J Pediatr.2006;148:296299.
  4. Flanders SA,Wachter RM.Hospitalists: the new model of inpatient medical care in the United States.Eur J Intern Med.2003;14:6570.
  5. Landrigan CP,Muret‐Wagstaff S,Chiang VW,Nigrin DJ,Goldman DA,Finklestein JA.Effect of a pediatric hospitalist system on housestaff education and experience.Arch Pediatr Adolesc Med.2002;156:877883.
  6. Plauth WH,Pantilat SZ,Wachter RM,Fenton CL.Hospitalists' perceptions of their residency training needs: results of a national survey.Am J Med.2001;111:247254.
  7. Srivastava R,Landrigan C,Gidwani P,Harary OH,Muret‐Wagstaff S,Homer CJ.Pediatric hospitalists in Canada and the United States: a survey of pediatric academic department chairs.Ambul Pediatr.2001;1:338339.
  8. Wachter RM.Hospitalists in the United States: mission accomplished or work in progress?N Engl J Med.2004;350:19351936.
  9. Althouse LA,Stockman JA.Pediatric workforce: a look at general pediatrics data from the American Board of Pediatrics.J Pediatr.2006;148:166169.
  10. Ottolini MC,Landrigan CP,Chiang VW,Stucky ER,PRIS survey: pediatric hospitalist roles and training needs [Abstr].Pediatr Res.2004;55:360A.
  11. Ranji SR,Rosenman DJ,Amin AN,Kripalani S.Hospital medicine fellowships: works in progress.Am J Med.2006;119:1.e11.e7.
  12. O'Leary KJ,Liebovitz DM,Baker DW.How hospitalists spend their time: insights on efficiency and safety.J Hosp Med.2006;1:8893.
  13. Carlson DW,Fentzke KM,Dawson JG.Pediatric hospitalists fill varied roles in the care of newborns.Pediatr Ann.2003;32:802810.
References
  1. Freed GL,Brzoznowski KF,Neighbors K,Lakhani I; The Research Advisory Committee of the American Board of Pediatrics.Characteristics of the pediatric hospitalist workforce: its roles and work environment.Pediatrics.2007;120:3339.
  2. Wachter RM.The evolution of the hospitalist model in the United States.Med Clin North Am.2002;86:687706.
  3. Freed GL,Uren RL.Hospitalists in children's hospitals: what we know now and what we need to know.J Pediatr.2006;148:296299.
  4. Flanders SA,Wachter RM.Hospitalists: the new model of inpatient medical care in the United States.Eur J Intern Med.2003;14:6570.
  5. Landrigan CP,Muret‐Wagstaff S,Chiang VW,Nigrin DJ,Goldman DA,Finklestein JA.Effect of a pediatric hospitalist system on housestaff education and experience.Arch Pediatr Adolesc Med.2002;156:877883.
  6. Plauth WH,Pantilat SZ,Wachter RM,Fenton CL.Hospitalists' perceptions of their residency training needs: results of a national survey.Am J Med.2001;111:247254.
  7. Srivastava R,Landrigan C,Gidwani P,Harary OH,Muret‐Wagstaff S,Homer CJ.Pediatric hospitalists in Canada and the United States: a survey of pediatric academic department chairs.Ambul Pediatr.2001;1:338339.
  8. Wachter RM.Hospitalists in the United States: mission accomplished or work in progress?N Engl J Med.2004;350:19351936.
  9. Althouse LA,Stockman JA.Pediatric workforce: a look at general pediatrics data from the American Board of Pediatrics.J Pediatr.2006;148:166169.
  10. Ottolini MC,Landrigan CP,Chiang VW,Stucky ER,PRIS survey: pediatric hospitalist roles and training needs [Abstr].Pediatr Res.2004;55:360A.
  11. Ranji SR,Rosenman DJ,Amin AN,Kripalani S.Hospital medicine fellowships: works in progress.Am J Med.2006;119:1.e11.e7.
  12. O'Leary KJ,Liebovitz DM,Baker DW.How hospitalists spend their time: insights on efficiency and safety.J Hosp Med.2006;1:8893.
  13. Carlson DW,Fentzke KM,Dawson JG.Pediatric hospitalists fill varied roles in the care of newborns.Pediatr Ann.2003;32:802810.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
179-186
Page Number
179-186
Article Type
Display Headline
Pediatric hospitalists: Training, current practice, and career goals
Display Headline
Pediatric hospitalists: Training, current practice, and career goals
Legacy Keywords
academic appointment, career trajectory, clinical practice, employment characteristics, job satisfaction
Legacy Keywords
academic appointment, career trajectory, clinical practice, employment characteristics, job satisfaction
Sections
Article Source

Copyright © 2009 Society of Hospital Medicine

Disallow All Ads
Correspondence Location
University of Michigan, 300 North Ingalls Building 6E08, Ann Arbor, MI 48109‐0456
Content Gating
No Gating (article Unlocked/Free)
Alternative CME
Article PDF Media

Takotsubo Cardiomyopathy

Article Type
Changed
Mon, 01/02/2017 - 19:34
Display Headline
Takotsubo cardiomyopathy presenting with dyspnea

Takotsubo cardiomyopathy, also known as transient left ventricular apical ballooning, stress cardiomyopathy, and broken heart syndrome, is a condition that mimics acute myocardial infarction. Patients typically present with chest pain, electrocardiographic changes consistent with acute ischemia or infarct, and elevated cardiac enzymes in the absence of significant coronary artery disease. Left ventriculography demonstrates a characteristic pattern of dysfunction: dyskinesis of the cardiac apex and hyperkinesis of the base. This resulting appearance of apical ballooning is reminiscent of the takotsubo, a Japanese octopus pot with a wide base and narrow top. The syndrome occurs almost exclusively in postmenopausal women and demonstrates a distinct temporal association with extreme emotional or physiological stress. The pathophysiology is poorly understood, but one theory suggests that the transient cardiomyopathy reflects myocardial stunning due to excessive sympathetic output.1 Treatment is supportive, and most patients rapidly recover normal systolic function.

A 57‐year‐old African American female with a past medical history significant only for chronic obstructive pulmonary disease presented with severe dyspnea that was progressive over several hours following the unexpected death of her son. She denied chest pain, palpitations, cough, or fever. On examination, she was afebrile with a blood pressure of 145/82 mm Hg, a pulse of 90 beats per minute, and a respiratory rate of 24 breaths per minute with oxygen saturations of 88% on room air. Lung examination revealed coarse breath sounds with a slightly prolonged expiration phase, but it was otherwise clear. Cardiac examination was unremarkable. Chest radiograph showed only emphysematous changes. Initial electrocardiogram and serial cardiac enzymes were negative. A computed tomography pulmonary angiogram showed no evidence of pulmonary embolism. The patient was admitted with the diagnosis of chronic obstructive pulmonary disease exacerbation and treated with supplemental oxygen, bronchodilators, and corticosteroids.

On the following day, the patient developed worsening dyspnea, hypoxia, and diffuse crackles on examination. Electrocardiogram at that time demonstrated ST‐segment elevations in leads V1 and V2 as well as T‐wave inversions in all precordial leads (Figure 1). The troponin‐I concentration was 1.92 ng/mL (<0.05 nL), and the brain natriuretic peptide concentration was 1425 pg/mL. The patient underwent urgent cardiac catheterization with no evidence of coronary artery obstruction. Left ventriculogram revealed a hyperdynamic base and akinetic apex extending into the mid‐heart (Figure 2). Left ventricular systolic function was severely reduced, with an estimated ejection fraction of 10% to 15%. The normal diastolic ventriculogram image is shown for comparison (Figure 3). These findings were felt to be consistent with takotsubo syndrome. The patient required inotropic support briefly but experienced full clinical recovery by the sixth hospital day.

Figure 1
Electrocardiogram showing ST‐segment elevations in leads V1 and V2 as well as T‐wave inversions in all precordial leads.
Figure 2
Left ventricular angiogram in systole demonstrating characteristic apical ballooning due to focal hypokinesis in takotsubo cardiomyopathy.
Figure 3
The patient's angiogram in diastole (shown for comparison).

DISCUSSION

Takotsubo cardiomyopathy was first described in Japan in 1991.2 Although the condition made a relatively recent debut in the United States, with the first case series published in 2003, subsequent reports have suggested that the condition is not rare.3 Recent analyses of Western populations estimate the prevalence to be approximately 2% among patients with acute coronary syndrome.1, 4, 5 Because women compose the majority of patients with takotsubo cardiomyopathy, the prevalence among women as a subset of patients with acute coronary syndrome is likely much higher. The syndrome has been described as a clinical entity in Japanese, European, Caucasian, and African American patients.2, 3 Interesting differences appear to exist among different ethnic groups. For example, evidence suggests that the condition is more likely to be precipitated by emotional stress in Caucasians, whereas physiological stress is a more frequent trigger in Asians.6

Although chest pain is described as a cardinal feature in takotsubo cardiomyopathy, existing data suggest that African American patients may lack this typical symptom. The first African American female reported with takotsubo syndrome presented with heart failure and hypotension in the absence of chest pain.1 Subsequently, Patel et al.7 reported 5 African American women with takotsubo syndrome. Three patients presented with dyspnea, and 2 presented with nausea: none of the patients experienced chest pain. Our case adds to this evidence by describing an African American woman with takotsubo syndrome whose presenting symptom was severe dyspnea without chest pain. Unlike the majority of reported cases, electrocardiographic and biomarker abnormalities were not present in our patient at admission. As with our patient, the diagnosis of takotsubo cardiomyopathy may initially be overlooked in African Americans because of the atypical presentation. As takotsubo syndrome becomes increasingly recognized in the United States, clinicians are encouraged to consider the diagnosis in African American women who present with severe dyspnea in the setting of extreme emotional or physiological stress. Further research on the pathophysiology of takotsubo cardiomyopathy is needed to explain why such differences in presenting symptoms may exist.

References
  1. Wittstein IS,Thiemann DR,Lima JAC, et al.Neurohormonal features of myocardial stunning due to sudden emotional stress.N Engl J Med.2005;352:540548.
  2. Dote K,Sato H,Tateishi H, et al.Myocardial stunning due to simultaneous multivessel coronary spasm: a review of 5 cases.J Cardiol.1991;21:203214.
  3. Seth PS,Aurigemma GP,Krasnow JM, et al.A syndrome of transient left ventricular apical wall motion abnormality in the absence of coronary disease: a perspective from the United States.Cardiology.2003;100:6166.
  4. Bybee KA,Prasad A,Barness GW, et al.Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular ballooning syndrome.Am J Cardiol.2004;94:343346.
  5. Elian D,Osherov A,Matetzky S, et al.Left ventricular apical ballooning: not an uncommon variant of acute myocardial infarction in women.Clin Cardiol.2006;29:912.
  6. Donohue D,Mohammed‐Reza M.Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome.Heart Fail Rev.2005;10:311316.
  7. Patel HM,Kantharia BK,Morris DL, et al.Takotsubo syndrome in African‐American women with atypical presentations: a single‐center experience.Clin Cardiol2007;30:1418.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
200-202
Legacy Keywords
apical ballooning, left ventricular dysfunction, myocardial infarction, stress cardiomyopathy, takotsubo
Sections
Article PDF
Article PDF

Takotsubo cardiomyopathy, also known as transient left ventricular apical ballooning, stress cardiomyopathy, and broken heart syndrome, is a condition that mimics acute myocardial infarction. Patients typically present with chest pain, electrocardiographic changes consistent with acute ischemia or infarct, and elevated cardiac enzymes in the absence of significant coronary artery disease. Left ventriculography demonstrates a characteristic pattern of dysfunction: dyskinesis of the cardiac apex and hyperkinesis of the base. This resulting appearance of apical ballooning is reminiscent of the takotsubo, a Japanese octopus pot with a wide base and narrow top. The syndrome occurs almost exclusively in postmenopausal women and demonstrates a distinct temporal association with extreme emotional or physiological stress. The pathophysiology is poorly understood, but one theory suggests that the transient cardiomyopathy reflects myocardial stunning due to excessive sympathetic output.1 Treatment is supportive, and most patients rapidly recover normal systolic function.

A 57‐year‐old African American female with a past medical history significant only for chronic obstructive pulmonary disease presented with severe dyspnea that was progressive over several hours following the unexpected death of her son. She denied chest pain, palpitations, cough, or fever. On examination, she was afebrile with a blood pressure of 145/82 mm Hg, a pulse of 90 beats per minute, and a respiratory rate of 24 breaths per minute with oxygen saturations of 88% on room air. Lung examination revealed coarse breath sounds with a slightly prolonged expiration phase, but it was otherwise clear. Cardiac examination was unremarkable. Chest radiograph showed only emphysematous changes. Initial electrocardiogram and serial cardiac enzymes were negative. A computed tomography pulmonary angiogram showed no evidence of pulmonary embolism. The patient was admitted with the diagnosis of chronic obstructive pulmonary disease exacerbation and treated with supplemental oxygen, bronchodilators, and corticosteroids.

On the following day, the patient developed worsening dyspnea, hypoxia, and diffuse crackles on examination. Electrocardiogram at that time demonstrated ST‐segment elevations in leads V1 and V2 as well as T‐wave inversions in all precordial leads (Figure 1). The troponin‐I concentration was 1.92 ng/mL (<0.05 nL), and the brain natriuretic peptide concentration was 1425 pg/mL. The patient underwent urgent cardiac catheterization with no evidence of coronary artery obstruction. Left ventriculogram revealed a hyperdynamic base and akinetic apex extending into the mid‐heart (Figure 2). Left ventricular systolic function was severely reduced, with an estimated ejection fraction of 10% to 15%. The normal diastolic ventriculogram image is shown for comparison (Figure 3). These findings were felt to be consistent with takotsubo syndrome. The patient required inotropic support briefly but experienced full clinical recovery by the sixth hospital day.

Figure 1
Electrocardiogram showing ST‐segment elevations in leads V1 and V2 as well as T‐wave inversions in all precordial leads.
Figure 2
Left ventricular angiogram in systole demonstrating characteristic apical ballooning due to focal hypokinesis in takotsubo cardiomyopathy.
Figure 3
The patient's angiogram in diastole (shown for comparison).

DISCUSSION

Takotsubo cardiomyopathy was first described in Japan in 1991.2 Although the condition made a relatively recent debut in the United States, with the first case series published in 2003, subsequent reports have suggested that the condition is not rare.3 Recent analyses of Western populations estimate the prevalence to be approximately 2% among patients with acute coronary syndrome.1, 4, 5 Because women compose the majority of patients with takotsubo cardiomyopathy, the prevalence among women as a subset of patients with acute coronary syndrome is likely much higher. The syndrome has been described as a clinical entity in Japanese, European, Caucasian, and African American patients.2, 3 Interesting differences appear to exist among different ethnic groups. For example, evidence suggests that the condition is more likely to be precipitated by emotional stress in Caucasians, whereas physiological stress is a more frequent trigger in Asians.6

Although chest pain is described as a cardinal feature in takotsubo cardiomyopathy, existing data suggest that African American patients may lack this typical symptom. The first African American female reported with takotsubo syndrome presented with heart failure and hypotension in the absence of chest pain.1 Subsequently, Patel et al.7 reported 5 African American women with takotsubo syndrome. Three patients presented with dyspnea, and 2 presented with nausea: none of the patients experienced chest pain. Our case adds to this evidence by describing an African American woman with takotsubo syndrome whose presenting symptom was severe dyspnea without chest pain. Unlike the majority of reported cases, electrocardiographic and biomarker abnormalities were not present in our patient at admission. As with our patient, the diagnosis of takotsubo cardiomyopathy may initially be overlooked in African Americans because of the atypical presentation. As takotsubo syndrome becomes increasingly recognized in the United States, clinicians are encouraged to consider the diagnosis in African American women who present with severe dyspnea in the setting of extreme emotional or physiological stress. Further research on the pathophysiology of takotsubo cardiomyopathy is needed to explain why such differences in presenting symptoms may exist.

Takotsubo cardiomyopathy, also known as transient left ventricular apical ballooning, stress cardiomyopathy, and broken heart syndrome, is a condition that mimics acute myocardial infarction. Patients typically present with chest pain, electrocardiographic changes consistent with acute ischemia or infarct, and elevated cardiac enzymes in the absence of significant coronary artery disease. Left ventriculography demonstrates a characteristic pattern of dysfunction: dyskinesis of the cardiac apex and hyperkinesis of the base. This resulting appearance of apical ballooning is reminiscent of the takotsubo, a Japanese octopus pot with a wide base and narrow top. The syndrome occurs almost exclusively in postmenopausal women and demonstrates a distinct temporal association with extreme emotional or physiological stress. The pathophysiology is poorly understood, but one theory suggests that the transient cardiomyopathy reflects myocardial stunning due to excessive sympathetic output.1 Treatment is supportive, and most patients rapidly recover normal systolic function.

A 57‐year‐old African American female with a past medical history significant only for chronic obstructive pulmonary disease presented with severe dyspnea that was progressive over several hours following the unexpected death of her son. She denied chest pain, palpitations, cough, or fever. On examination, she was afebrile with a blood pressure of 145/82 mm Hg, a pulse of 90 beats per minute, and a respiratory rate of 24 breaths per minute with oxygen saturations of 88% on room air. Lung examination revealed coarse breath sounds with a slightly prolonged expiration phase, but it was otherwise clear. Cardiac examination was unremarkable. Chest radiograph showed only emphysematous changes. Initial electrocardiogram and serial cardiac enzymes were negative. A computed tomography pulmonary angiogram showed no evidence of pulmonary embolism. The patient was admitted with the diagnosis of chronic obstructive pulmonary disease exacerbation and treated with supplemental oxygen, bronchodilators, and corticosteroids.

On the following day, the patient developed worsening dyspnea, hypoxia, and diffuse crackles on examination. Electrocardiogram at that time demonstrated ST‐segment elevations in leads V1 and V2 as well as T‐wave inversions in all precordial leads (Figure 1). The troponin‐I concentration was 1.92 ng/mL (<0.05 nL), and the brain natriuretic peptide concentration was 1425 pg/mL. The patient underwent urgent cardiac catheterization with no evidence of coronary artery obstruction. Left ventriculogram revealed a hyperdynamic base and akinetic apex extending into the mid‐heart (Figure 2). Left ventricular systolic function was severely reduced, with an estimated ejection fraction of 10% to 15%. The normal diastolic ventriculogram image is shown for comparison (Figure 3). These findings were felt to be consistent with takotsubo syndrome. The patient required inotropic support briefly but experienced full clinical recovery by the sixth hospital day.

Figure 1
Electrocardiogram showing ST‐segment elevations in leads V1 and V2 as well as T‐wave inversions in all precordial leads.
Figure 2
Left ventricular angiogram in systole demonstrating characteristic apical ballooning due to focal hypokinesis in takotsubo cardiomyopathy.
Figure 3
The patient's angiogram in diastole (shown for comparison).

DISCUSSION

Takotsubo cardiomyopathy was first described in Japan in 1991.2 Although the condition made a relatively recent debut in the United States, with the first case series published in 2003, subsequent reports have suggested that the condition is not rare.3 Recent analyses of Western populations estimate the prevalence to be approximately 2% among patients with acute coronary syndrome.1, 4, 5 Because women compose the majority of patients with takotsubo cardiomyopathy, the prevalence among women as a subset of patients with acute coronary syndrome is likely much higher. The syndrome has been described as a clinical entity in Japanese, European, Caucasian, and African American patients.2, 3 Interesting differences appear to exist among different ethnic groups. For example, evidence suggests that the condition is more likely to be precipitated by emotional stress in Caucasians, whereas physiological stress is a more frequent trigger in Asians.6

Although chest pain is described as a cardinal feature in takotsubo cardiomyopathy, existing data suggest that African American patients may lack this typical symptom. The first African American female reported with takotsubo syndrome presented with heart failure and hypotension in the absence of chest pain.1 Subsequently, Patel et al.7 reported 5 African American women with takotsubo syndrome. Three patients presented with dyspnea, and 2 presented with nausea: none of the patients experienced chest pain. Our case adds to this evidence by describing an African American woman with takotsubo syndrome whose presenting symptom was severe dyspnea without chest pain. Unlike the majority of reported cases, electrocardiographic and biomarker abnormalities were not present in our patient at admission. As with our patient, the diagnosis of takotsubo cardiomyopathy may initially be overlooked in African Americans because of the atypical presentation. As takotsubo syndrome becomes increasingly recognized in the United States, clinicians are encouraged to consider the diagnosis in African American women who present with severe dyspnea in the setting of extreme emotional or physiological stress. Further research on the pathophysiology of takotsubo cardiomyopathy is needed to explain why such differences in presenting symptoms may exist.

References
  1. Wittstein IS,Thiemann DR,Lima JAC, et al.Neurohormonal features of myocardial stunning due to sudden emotional stress.N Engl J Med.2005;352:540548.
  2. Dote K,Sato H,Tateishi H, et al.Myocardial stunning due to simultaneous multivessel coronary spasm: a review of 5 cases.J Cardiol.1991;21:203214.
  3. Seth PS,Aurigemma GP,Krasnow JM, et al.A syndrome of transient left ventricular apical wall motion abnormality in the absence of coronary disease: a perspective from the United States.Cardiology.2003;100:6166.
  4. Bybee KA,Prasad A,Barness GW, et al.Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular ballooning syndrome.Am J Cardiol.2004;94:343346.
  5. Elian D,Osherov A,Matetzky S, et al.Left ventricular apical ballooning: not an uncommon variant of acute myocardial infarction in women.Clin Cardiol.2006;29:912.
  6. Donohue D,Mohammed‐Reza M.Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome.Heart Fail Rev.2005;10:311316.
  7. Patel HM,Kantharia BK,Morris DL, et al.Takotsubo syndrome in African‐American women with atypical presentations: a single‐center experience.Clin Cardiol2007;30:1418.
References
  1. Wittstein IS,Thiemann DR,Lima JAC, et al.Neurohormonal features of myocardial stunning due to sudden emotional stress.N Engl J Med.2005;352:540548.
  2. Dote K,Sato H,Tateishi H, et al.Myocardial stunning due to simultaneous multivessel coronary spasm: a review of 5 cases.J Cardiol.1991;21:203214.
  3. Seth PS,Aurigemma GP,Krasnow JM, et al.A syndrome of transient left ventricular apical wall motion abnormality in the absence of coronary disease: a perspective from the United States.Cardiology.2003;100:6166.
  4. Bybee KA,Prasad A,Barness GW, et al.Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular ballooning syndrome.Am J Cardiol.2004;94:343346.
  5. Elian D,Osherov A,Matetzky S, et al.Left ventricular apical ballooning: not an uncommon variant of acute myocardial infarction in women.Clin Cardiol.2006;29:912.
  6. Donohue D,Mohammed‐Reza M.Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome.Heart Fail Rev.2005;10:311316.
  7. Patel HM,Kantharia BK,Morris DL, et al.Takotsubo syndrome in African‐American women with atypical presentations: a single‐center experience.Clin Cardiol2007;30:1418.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
200-202
Page Number
200-202
Article Type
Display Headline
Takotsubo cardiomyopathy presenting with dyspnea
Display Headline
Takotsubo cardiomyopathy presenting with dyspnea
Legacy Keywords
apical ballooning, left ventricular dysfunction, myocardial infarction, stress cardiomyopathy, takotsubo
Legacy Keywords
apical ballooning, left ventricular dysfunction, myocardial infarction, stress cardiomyopathy, takotsubo
Sections
Article Source
Copyright © 2009 Society of Hospital Medicine
Disallow All Ads
Correspondence Location
Department of Internal Medicine, University of South Florida College of Medicine, 2‐A Columbia Drive, Tampa, FL 33629
Content Gating
Gated (full article locked unless allowed per User)
Gating Strategy
First Peek Free
Article PDF Media

Legionella pneumonia and use of the Legionella urinary antigen test

Article Type
Changed
Mon, 01/02/2017 - 19:34
Display Headline
Legionella pneumonia and use of the Legionella urinary antigen test

A 33‐year‐old Caucasian woman presented to an outside hospital with a 10‐day history of fever, cough, and progressive dyspnea on exertion. Ten days prior to the onset of symptoms, she had traveled to Calgary, Alberta, Canada. Her niece and nephew had recently suffered upper respiratory symptoms. Additional review of systems was negative for joint pain, rash, diarrhea, or bloody stools. She had a history of ulcerative colitis, primary sclerosing cholangitis, and juvenile rheumatoid arthritis. Her outpatient medications included prednisone 10 mg daily, methotrexate 7.5 mg weekly, and ursodiol 200 mg 3 times daily. She was employed at a local hospital and her annual purified protein derivative (PPD) test had been negative. Computed tomography angiography demonstrated bilateral patchy consolidation. Vancomycin, levofloxacin, piperacillin/tazobactam, and fluconazole were initiated and she was transferred to our hospital for further evaluation.

On arrival, her vital signs were within normal limits. She was breathing comfortably but on auscultation had crackles at the right‐mid lung field. A complete blood cell count demonstrated a white blood cell count of 7000/L with left shift, hemoglobin 10.7 g/dL, and platelet count 156,000/L. Liver function tests showed albumin 2.6 g/dL, total bilirubin 9.0 mg/dL with conjugated fraction 6.6 mg/dL, alkaline phosphatase 586 U/L, aspartate aminotransferase 104 U/L, and alanine aminotransferase 72 U/L; these were all near her baseline. The basic metabolic panel was within normal limits. A chest X‐ray showed dense areas of consolidation in the lingula and left upper lobe. All antibiotics from the outside hospital were discontinued and empiric moxifloxacin was initiated.

On hospital day 1, she underwent bronchoscopy, which yielded cloudy fluid from the bronchoalveolar lavage (BAL). Initial BAL gram stain showed moderate white blood cells but no organisms; fungal smears and stains for acid fast bacilli were negative. Blood cultures and Legionella and Streptococcus urinary antigen tests were negative. The remainder of her hospital course was uneventful. Her shortness of breath improved and she remained afebrile. She was discharged home on a 10‐day course of moxifloxacin with close follow‐up. Six days after the BAL specimen was collected, the culture grew Legionella micdadei. Repeat chest film 2 weeks later demonstrated resolution of the original findings.

DISCUSSION

Legionella is responsible for 8000 to 18,000 hospitalizations for pneumonia annually.1 It is associated with community‐acquired, hospital‐acquired, and travel‐associated pneumonia. Twenty‐five Legionella species have been identified and 8 species are associated with pneumonia in humans.2 Community‐acquired and travel‐acquired Legionella pneumonia is most commonly caused by Legionella pneumophila; the second most common cause is L. micdadei.2, 3 It was initially identified in 1977 at the University of Pittsburgh in renal transplant patients with acute pneumonitis and is known as the Pittsburgh pneumonia agent. Similar cases were identified in a group of immunocompromised patients in Virginia, all of whom were receiving steroids and cytotoxic chemotherapy. It is unclear why L. micdadei predominates in this population, but is likely related to its decreased virulence compared to L. pneumophila. The definitive mode of transmission of L. micdadei is not known; it may be from contaminated water supplies but infections from inhalation of respiratory secretions have also been documented.2 While L. micdadei is not commonly seen in travel‐associated Legionella pneumonia, the patient's immunocompromised status secondary to the treatment of her underlying medical conditions made her particularly vulnerable. Given the temporal association with her trip, she was most likely exposed during her travels but her hospital employment should also be considered.

Legionella pneumonia is underdiagnosed because of difficulty distinguishing it from other types of pneumonia, failure to order diagnostic tests, and variable sensitivity of available diagnostic tests.4 Culture is considered the gold standard and is ideally performed from lower respiratory secretions, but variable sensitivity due to interlaboratory variation (range, 10%‐80%) limits its use.3, 4 Direct immunofluorescence assay (DFA) testing of respiratory secretions is available but also limited by poor sensitivity. Both culture and DFA have specificities approaching 100%. A newer test, the Legionella urinary antigen test, is an immunochromatographic assay. It is less technically difficult and results are available in less than 1 hour. The assay can detect the antigen in the urine starting 1 day after the onset of symptoms, and can remain positive for days or weeks following treatment.4

With the introduction and wide availability of the Legionella urinary antigen test, it is important to consider its limitations. While the test carries a high specificity, it detects only the soluble antigen of Legionella pneumophila serogroup 1. Thus, as in this case, the urinary test can be negative when infection is caused by other species such as L. micdadei. In the literature, the urine assay's sensitivity is variously reported at 45% to 100% with lower sensitivities in circumstances such as hospital‐acquired disease, where the association with other species is higher than in the community setting.3, 4 For instance, in nosocomial infections, the reported sensitivity is 45%.3 False‐positive results have also been seen in patients with serum sickness.4

The Legionella urinary antigen test has improved detection of Legionella pneumonia. Given its limitations, it is likely to be most accurate in community‐acquired and travel‐acquired cases.3 The Centers for Disease Control and Prevention recommend testing for Legionella in pneumonia patients requiring admission to the intensive care unit (ICU), immunocompromised patients, patients who traveled within 2 weeks of presentation, and those who have failed treatment with beta‐lactams or cephalosporins. A negative test does not rule out Legionella infection and additional testing with bronchoscopy may be indicated, especially in immunocompromised hosts.4

References
  1. Centers for Disease Control. Legionellosis Resource Site (Legionnaires' Disease and Pontiac Fever). Top 10 Things Every Clinician Needs to Know About Legionellosis. Available at http://www.cdc.gov/legionella/top10.htm. Accessed February2009.
  2. Guo‐Dong G,Yu VL,Vickers RM.Disease due to the legionellaceae (other than Legionella pneumophila): historical, microbiological, clinical, and epidemiological review.Medicine.1989;68:116132.
  3. Helbig J,Uldum S,Bernander S, et al.Clinical utility of urinary antigen detection for diagnosis of community‐acquired, travel‐associated, and nosocomial legionnaire's disease.J Clin Microbiol.2003;41(2):838840.
  4. Murdoch D.Diagnosis of Legionella infection.Clin Infect Dis.2003;36:6469.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
E1-E2
Legacy Keywords
community‐acquired and nosocomial, diagnostic decision making, evidence based medicine, pneumonia
Sections
Article PDF
Article PDF

A 33‐year‐old Caucasian woman presented to an outside hospital with a 10‐day history of fever, cough, and progressive dyspnea on exertion. Ten days prior to the onset of symptoms, she had traveled to Calgary, Alberta, Canada. Her niece and nephew had recently suffered upper respiratory symptoms. Additional review of systems was negative for joint pain, rash, diarrhea, or bloody stools. She had a history of ulcerative colitis, primary sclerosing cholangitis, and juvenile rheumatoid arthritis. Her outpatient medications included prednisone 10 mg daily, methotrexate 7.5 mg weekly, and ursodiol 200 mg 3 times daily. She was employed at a local hospital and her annual purified protein derivative (PPD) test had been negative. Computed tomography angiography demonstrated bilateral patchy consolidation. Vancomycin, levofloxacin, piperacillin/tazobactam, and fluconazole were initiated and she was transferred to our hospital for further evaluation.

On arrival, her vital signs were within normal limits. She was breathing comfortably but on auscultation had crackles at the right‐mid lung field. A complete blood cell count demonstrated a white blood cell count of 7000/L with left shift, hemoglobin 10.7 g/dL, and platelet count 156,000/L. Liver function tests showed albumin 2.6 g/dL, total bilirubin 9.0 mg/dL with conjugated fraction 6.6 mg/dL, alkaline phosphatase 586 U/L, aspartate aminotransferase 104 U/L, and alanine aminotransferase 72 U/L; these were all near her baseline. The basic metabolic panel was within normal limits. A chest X‐ray showed dense areas of consolidation in the lingula and left upper lobe. All antibiotics from the outside hospital were discontinued and empiric moxifloxacin was initiated.

On hospital day 1, she underwent bronchoscopy, which yielded cloudy fluid from the bronchoalveolar lavage (BAL). Initial BAL gram stain showed moderate white blood cells but no organisms; fungal smears and stains for acid fast bacilli were negative. Blood cultures and Legionella and Streptococcus urinary antigen tests were negative. The remainder of her hospital course was uneventful. Her shortness of breath improved and she remained afebrile. She was discharged home on a 10‐day course of moxifloxacin with close follow‐up. Six days after the BAL specimen was collected, the culture grew Legionella micdadei. Repeat chest film 2 weeks later demonstrated resolution of the original findings.

DISCUSSION

Legionella is responsible for 8000 to 18,000 hospitalizations for pneumonia annually.1 It is associated with community‐acquired, hospital‐acquired, and travel‐associated pneumonia. Twenty‐five Legionella species have been identified and 8 species are associated with pneumonia in humans.2 Community‐acquired and travel‐acquired Legionella pneumonia is most commonly caused by Legionella pneumophila; the second most common cause is L. micdadei.2, 3 It was initially identified in 1977 at the University of Pittsburgh in renal transplant patients with acute pneumonitis and is known as the Pittsburgh pneumonia agent. Similar cases were identified in a group of immunocompromised patients in Virginia, all of whom were receiving steroids and cytotoxic chemotherapy. It is unclear why L. micdadei predominates in this population, but is likely related to its decreased virulence compared to L. pneumophila. The definitive mode of transmission of L. micdadei is not known; it may be from contaminated water supplies but infections from inhalation of respiratory secretions have also been documented.2 While L. micdadei is not commonly seen in travel‐associated Legionella pneumonia, the patient's immunocompromised status secondary to the treatment of her underlying medical conditions made her particularly vulnerable. Given the temporal association with her trip, she was most likely exposed during her travels but her hospital employment should also be considered.

Legionella pneumonia is underdiagnosed because of difficulty distinguishing it from other types of pneumonia, failure to order diagnostic tests, and variable sensitivity of available diagnostic tests.4 Culture is considered the gold standard and is ideally performed from lower respiratory secretions, but variable sensitivity due to interlaboratory variation (range, 10%‐80%) limits its use.3, 4 Direct immunofluorescence assay (DFA) testing of respiratory secretions is available but also limited by poor sensitivity. Both culture and DFA have specificities approaching 100%. A newer test, the Legionella urinary antigen test, is an immunochromatographic assay. It is less technically difficult and results are available in less than 1 hour. The assay can detect the antigen in the urine starting 1 day after the onset of symptoms, and can remain positive for days or weeks following treatment.4

With the introduction and wide availability of the Legionella urinary antigen test, it is important to consider its limitations. While the test carries a high specificity, it detects only the soluble antigen of Legionella pneumophila serogroup 1. Thus, as in this case, the urinary test can be negative when infection is caused by other species such as L. micdadei. In the literature, the urine assay's sensitivity is variously reported at 45% to 100% with lower sensitivities in circumstances such as hospital‐acquired disease, where the association with other species is higher than in the community setting.3, 4 For instance, in nosocomial infections, the reported sensitivity is 45%.3 False‐positive results have also been seen in patients with serum sickness.4

The Legionella urinary antigen test has improved detection of Legionella pneumonia. Given its limitations, it is likely to be most accurate in community‐acquired and travel‐acquired cases.3 The Centers for Disease Control and Prevention recommend testing for Legionella in pneumonia patients requiring admission to the intensive care unit (ICU), immunocompromised patients, patients who traveled within 2 weeks of presentation, and those who have failed treatment with beta‐lactams or cephalosporins. A negative test does not rule out Legionella infection and additional testing with bronchoscopy may be indicated, especially in immunocompromised hosts.4

A 33‐year‐old Caucasian woman presented to an outside hospital with a 10‐day history of fever, cough, and progressive dyspnea on exertion. Ten days prior to the onset of symptoms, she had traveled to Calgary, Alberta, Canada. Her niece and nephew had recently suffered upper respiratory symptoms. Additional review of systems was negative for joint pain, rash, diarrhea, or bloody stools. She had a history of ulcerative colitis, primary sclerosing cholangitis, and juvenile rheumatoid arthritis. Her outpatient medications included prednisone 10 mg daily, methotrexate 7.5 mg weekly, and ursodiol 200 mg 3 times daily. She was employed at a local hospital and her annual purified protein derivative (PPD) test had been negative. Computed tomography angiography demonstrated bilateral patchy consolidation. Vancomycin, levofloxacin, piperacillin/tazobactam, and fluconazole were initiated and she was transferred to our hospital for further evaluation.

On arrival, her vital signs were within normal limits. She was breathing comfortably but on auscultation had crackles at the right‐mid lung field. A complete blood cell count demonstrated a white blood cell count of 7000/L with left shift, hemoglobin 10.7 g/dL, and platelet count 156,000/L. Liver function tests showed albumin 2.6 g/dL, total bilirubin 9.0 mg/dL with conjugated fraction 6.6 mg/dL, alkaline phosphatase 586 U/L, aspartate aminotransferase 104 U/L, and alanine aminotransferase 72 U/L; these were all near her baseline. The basic metabolic panel was within normal limits. A chest X‐ray showed dense areas of consolidation in the lingula and left upper lobe. All antibiotics from the outside hospital were discontinued and empiric moxifloxacin was initiated.

On hospital day 1, she underwent bronchoscopy, which yielded cloudy fluid from the bronchoalveolar lavage (BAL). Initial BAL gram stain showed moderate white blood cells but no organisms; fungal smears and stains for acid fast bacilli were negative. Blood cultures and Legionella and Streptococcus urinary antigen tests were negative. The remainder of her hospital course was uneventful. Her shortness of breath improved and she remained afebrile. She was discharged home on a 10‐day course of moxifloxacin with close follow‐up. Six days after the BAL specimen was collected, the culture grew Legionella micdadei. Repeat chest film 2 weeks later demonstrated resolution of the original findings.

DISCUSSION

Legionella is responsible for 8000 to 18,000 hospitalizations for pneumonia annually.1 It is associated with community‐acquired, hospital‐acquired, and travel‐associated pneumonia. Twenty‐five Legionella species have been identified and 8 species are associated with pneumonia in humans.2 Community‐acquired and travel‐acquired Legionella pneumonia is most commonly caused by Legionella pneumophila; the second most common cause is L. micdadei.2, 3 It was initially identified in 1977 at the University of Pittsburgh in renal transplant patients with acute pneumonitis and is known as the Pittsburgh pneumonia agent. Similar cases were identified in a group of immunocompromised patients in Virginia, all of whom were receiving steroids and cytotoxic chemotherapy. It is unclear why L. micdadei predominates in this population, but is likely related to its decreased virulence compared to L. pneumophila. The definitive mode of transmission of L. micdadei is not known; it may be from contaminated water supplies but infections from inhalation of respiratory secretions have also been documented.2 While L. micdadei is not commonly seen in travel‐associated Legionella pneumonia, the patient's immunocompromised status secondary to the treatment of her underlying medical conditions made her particularly vulnerable. Given the temporal association with her trip, she was most likely exposed during her travels but her hospital employment should also be considered.

Legionella pneumonia is underdiagnosed because of difficulty distinguishing it from other types of pneumonia, failure to order diagnostic tests, and variable sensitivity of available diagnostic tests.4 Culture is considered the gold standard and is ideally performed from lower respiratory secretions, but variable sensitivity due to interlaboratory variation (range, 10%‐80%) limits its use.3, 4 Direct immunofluorescence assay (DFA) testing of respiratory secretions is available but also limited by poor sensitivity. Both culture and DFA have specificities approaching 100%. A newer test, the Legionella urinary antigen test, is an immunochromatographic assay. It is less technically difficult and results are available in less than 1 hour. The assay can detect the antigen in the urine starting 1 day after the onset of symptoms, and can remain positive for days or weeks following treatment.4

With the introduction and wide availability of the Legionella urinary antigen test, it is important to consider its limitations. While the test carries a high specificity, it detects only the soluble antigen of Legionella pneumophila serogroup 1. Thus, as in this case, the urinary test can be negative when infection is caused by other species such as L. micdadei. In the literature, the urine assay's sensitivity is variously reported at 45% to 100% with lower sensitivities in circumstances such as hospital‐acquired disease, where the association with other species is higher than in the community setting.3, 4 For instance, in nosocomial infections, the reported sensitivity is 45%.3 False‐positive results have also been seen in patients with serum sickness.4

The Legionella urinary antigen test has improved detection of Legionella pneumonia. Given its limitations, it is likely to be most accurate in community‐acquired and travel‐acquired cases.3 The Centers for Disease Control and Prevention recommend testing for Legionella in pneumonia patients requiring admission to the intensive care unit (ICU), immunocompromised patients, patients who traveled within 2 weeks of presentation, and those who have failed treatment with beta‐lactams or cephalosporins. A negative test does not rule out Legionella infection and additional testing with bronchoscopy may be indicated, especially in immunocompromised hosts.4

References
  1. Centers for Disease Control. Legionellosis Resource Site (Legionnaires' Disease and Pontiac Fever). Top 10 Things Every Clinician Needs to Know About Legionellosis. Available at http://www.cdc.gov/legionella/top10.htm. Accessed February2009.
  2. Guo‐Dong G,Yu VL,Vickers RM.Disease due to the legionellaceae (other than Legionella pneumophila): historical, microbiological, clinical, and epidemiological review.Medicine.1989;68:116132.
  3. Helbig J,Uldum S,Bernander S, et al.Clinical utility of urinary antigen detection for diagnosis of community‐acquired, travel‐associated, and nosocomial legionnaire's disease.J Clin Microbiol.2003;41(2):838840.
  4. Murdoch D.Diagnosis of Legionella infection.Clin Infect Dis.2003;36:6469.
References
  1. Centers for Disease Control. Legionellosis Resource Site (Legionnaires' Disease and Pontiac Fever). Top 10 Things Every Clinician Needs to Know About Legionellosis. Available at http://www.cdc.gov/legionella/top10.htm. Accessed February2009.
  2. Guo‐Dong G,Yu VL,Vickers RM.Disease due to the legionellaceae (other than Legionella pneumophila): historical, microbiological, clinical, and epidemiological review.Medicine.1989;68:116132.
  3. Helbig J,Uldum S,Bernander S, et al.Clinical utility of urinary antigen detection for diagnosis of community‐acquired, travel‐associated, and nosocomial legionnaire's disease.J Clin Microbiol.2003;41(2):838840.
  4. Murdoch D.Diagnosis of Legionella infection.Clin Infect Dis.2003;36:6469.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
E1-E2
Page Number
E1-E2
Article Type
Display Headline
Legionella pneumonia and use of the Legionella urinary antigen test
Display Headline
Legionella pneumonia and use of the Legionella urinary antigen test
Legacy Keywords
community‐acquired and nosocomial, diagnostic decision making, evidence based medicine, pneumonia
Legacy Keywords
community‐acquired and nosocomial, diagnostic decision making, evidence based medicine, pneumonia
Sections
Article Source
Copyright © 2009 Society of Hospital Medicine
Disallow All Ads
Correspondence Location
5841 S. Maryland Ave, MC 2007, W316, Chicago, IL 60637
Content Gating
Gated (full article locked unless allowed per User)
Gating Strategy
First Peek Free
Article PDF Media

Pediatric Hospital Medicine Fellowships

Article Type
Changed
Sun, 05/28/2017 - 21:49
Display Headline
Characteristics of pediatric hospital medicine fellowships and training programs

The field of pediatric hospital medicine is undergoing rapid growth. In 2002, there were approximately 600 pediatric hospitalists1 and in 2006 this number was estimated to be approximately 1000.2 A recent study found that approximately 25% of pediatric hospitalist practices are less than 2 years old.3 As such, there are many new physicians entering the field and most do so without specific training in hospital medicine prior to beginning their employment.4 There is also significant variability in the roles, work patterns, and scope of practice across institutions,3 and hospitalists are engaged in a wide variety of clinical, educational, and administrative functions.

A survey of pediatric department chairs in 2001 found that very few believed that any additional training beyond a pediatric residency was required to perform hospitalist medicine.5 However, since then the field has undergone significant growth. A more recent survey of practicing hospitalists found that 92% believed there was a need for additional training in a variety of domains.6 Specifically, respondents were most interested in achieving greater skill in performing critical care procedures and academic training. These hospitalists regarded pediatric hospitalist fellowships as the best way to gain the additional skills in teaching, research, and administration needed for their positions.

Nonetheless, for a variety of reasons, not the least of which is perhaps the paucity of hospitalist fellowship training programs, few hospitalists in practice today have completed a fellowship in hospital medicine. Over the past several years, a number of pediatric‐specific hospitalist fellowship programs have been initiated, yet little is known of their requirements or curricula. We conducted a study to explore the structure, components, and training goals of the pediatric hospitalist fellowship programs in North America.

MATERIALS AND METHODS

Sample

To examine the characteristics of pediatric hospitalist training in North America, we examined all 8 fellowships or training programs that were in existence in early 2007. The total sample included the following sites: Children's Hospital Boston, Children's Specialists of San Diego, Children's National Medical Center, Children's Healthcare of Atlanta, Texas Children's Hospital, All Children's Hospital, University of North Carolina, and The Hospital for Sick Children.

Survey Instrument

We constructed a 17‐item structured questionnaire to be administered by phone. The instrument was designed to be completed in approximately 10 minutes. Questionnaire items focused on documenting the goals, training, requirements, and clinical duties that characterize current pediatric hospitalist training programs. The questionnaire was comprised of a mixture of fixed‐choice and open‐ended questions. A draft of the instrument was shared with representatives of the Society of Hospital Medicine Pediatrics Committee for comment and suggestions.

Questionnaire Administration

The research team sent a prenotification letter to directors of the 8 pediatric hospitalist training programs to inform them of the research study. From February through June 2007, research staff contacted the directors of the programs, explained the purpose of the study, and obtained verbal consent.

Data Analysis

Responses were reviewed to compare and contrast the characteristics of the various programs. The study was approved by the University of Michigan Medical Institutional Review Board.

RESULTS

Response Rate

Of the 8 training programs, all completed the survey, representing a response rate of 100%. One institution offers 2 separate fellowship paths: academic and clinical.

Pediatric Hospitalist Fellowship and Training Program Overview

The first pediatric hospital medicine fellowship was initiated 15 years ago. However, the majority of pediatric hospitalist training programs in North America were established more recently, between 2003 and 2007.

Most pediatric hospitalist training programs offer 1 position per year. The duration of the training programs range from 1 to 3 years. Minimum clinical duties required by the programs vary from 4 to 8 months and the maximum amount of clinical time permitted ranges from 4 to 20 months. Most programs indicated that there is some flexibility in the clinical duties required or available to the fellows.

Six of the 8 programs offer an academic degree. Table 1 provides an overview of the programs, types of degrees offered, and funding sources for academic work. Subsequent tables provide blinded results to protect respondent confidentiality.

Pediatric Hospital Medicine Fellowships and Training Programs in North America, 2007
ProgramYear EstablishedDivisionNumber of Positions, 2007Duration of ProgramMinimum Clinical TimeMaximum Clinical TimeDegree Possible?Who Pays for Degree?
  • Abbreviations: MAS, Master of Academic Sciences; MEd, Master of Education; MME, Master of Medical Education; MPH, Master of Public Health; MPP, Master of Public Policy; MS, Master of Science.

Toronto‐Academic1992Pediatric medicine32 years4 months4 monthsYes: fellow's choiceFellow
Children's Boston1998Emergency medicine12 years8 months12 monthsYes: MPH, MEd, MPPDepart. funds; Externalfunds (creative)
Children's National2003Hospital medicine1‐22‐3 years6 months20 monthsYes: MPHFaculty benefits
Children's Spec. San Diego2003Hospital medicine11‐2 years7 monthsNAYes: MASDivision
Toronto‐Clinical2004Pediatric medicine11 year8 months8 monthsNoNA
Texas2005Emergency medicine12 years8 months8 monthsYes: MPH, MMEVaries
University of North Carolina2006General pediatrics and adolescent medicine11 year5 months6 monthsNoNA
All Children's2007General pediatrics12 years8 months9 monthsYes: MPH, MSExternal funding pending (federal grants)
Children's Atlanta2007Pediatric hospitalist section11 year6 months6 monthsNoNA

The number of fellowship or training program positions available each year has remained fairly consistent. However, to date, enrollment has not kept up with position availability (Table 2).

Pediatric Hospital Medicine Fellowship and Training Program Availability and Enrollment
Program2006‐2007 Positions Available2006‐2007 Fellows Enrolled2007‐2008 Positions Available
ANANA1
B212
C111
DNANA1
E102
F101
G203
H121
I110

Program Goals

Seven out of 8 programs reported the provision of advanced training in the clinical care of hospitalized patients, quality improvement (QI), and hospital administration to be central goals of their training program. Six respondents reported the provision of training in the education of medical students and residents to be a primary goal of their program, while 5 indicated training in health services research to be a primary goal.

Participation in General Hospital Activities

Trainees in all programs participate in clinical care, resident education, student education, research activities, and hospital committees. Seven out of 8 programs reported that fellows or trainees participate in patient safety activities and guideline development.

Formal Training

Half of the programs reported that they provide formal coursework in areas of education and hospital administration including quality improvement, resident teaching, and student teaching. Three of the 8 programs provide formal coursework in hospital economics.

Three of the 8 programs provide seminars in resident teaching, student teaching, hospital economics, and leading a healthcare team (Table 3).

Formal Hospital Administration Training Provided by Pediatric Hospitalist Fellowship and Training Programs
ProgramsResident TeachingStudent TeachingHospital EconomicsQuality ImprovementLeading a Healthcare Team
CourseworkSeminarsCourseworkSeminarsCourseworkSeminarsCourseworkSeminarsCourseworkSeminars
  • NOTE: Blank equals No.

A Yes Yes YesYes   
BYes Yes Yes Yes Yes 
C    YesYesYesYes Yes
DYes Yes Yes Yes Yes 
E Yes Yes   Yes Yes
F     Yes    
GYesYesYesYes   Yes Yes
HYesYesYesYes   Yes Yes
IYes Yes       

Seven of 8 pediatric hospitalist training programs provide formal coursework in epidemiology and research methodology. Six programs reported that they provide formal coursework in biostatistics and 5 in publications or grant writing. Four offer seminars in health economics, research methodology, and QI methodology (Table 4).

Formal Research Training Provided by Pediatric Hospitalist Fellowship and Training Programs
 EpidemiologyBiostatisticsHealth EconomicsResearch MethodologyQI MethodologyPublications/Grant WritingTranslation ResearchEducational Research
CourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminar
  • NOTE: Blank equals No.

AYes Yes  YesYes  YesYes Yes Yes 
BYes Yes Yes Yes Yes YesYesYes Yes 
CYes Yes  YesYesYes Yes Yes    
DYes Yes  YesYes Yes Yes   Yes 
EYes Yes Yes YesYes Yes Yes    
FYes  Yes  YesYes  YesYes    
GYesYesYesYesYesYesYesYesYesYesYesYesYesYesYesYes
HYesYesYesYesYesYesYesYesYesYesYesYesYesYesYesYes
I                

Program Requirements

Seven pediatric hospitalist training programs require fellows to complete a research project. Six programs reported that they require fellows or trainees to complete a quality improvement project or participate on a hospital committee. Six of the programs require pediatric hospitalist fellows to attempt to present at a national meeting, and 4 programs require that fellows attempt to publish their research in a peer‐reviewed publication. Graduate degrees are required at 3 of the 8 pediatric hospitalist training programs (Table 5).

Fellowship or Training Program Requirements
 QI ProjectResearch ProjectAbstract/Presentation at National Meeting*Peer‐Reviewed Publication*Committee Participation at HospitalAttending on General Ward Leading Resident TeamSpecific Advanced Clinical TrainingGraduate Degree ProgramOther
  • NOTE: Blank equals No.

  • Required to try.

AYesYesYesYesYesYes Yes 
B Yes   Yes   
CYesYesYesYesYesYesYes  
DYesYesYes YesYesYes  
EYesYesYesYesYes YesYes 
FYesYesYesYesYesYesYes  
GYesYesYes    Yes 
H         
I    YesYesYes Journal club

Clinical Service Requirements

All programs indicated that they require the fellow or trainee to serve as an attending on the general pediatric ward. Five programs require the fellow or trainee to provide service at the fellow or PL‐3 level in the pediatric intensive care unit (PICU), anesthesia service, and transport team. Four programs reported that they require service in the emergency department, and 3 programs require service in the neonatal intensive care unit (NICU), newborn nursery, and general pediatric ward at the fellow or PL‐3 level. Only 2 programs require service in the pediatric subspecialty ward, and 1 program requires service in outpatient urgent care. No program requires primary care service (Table 6).

Assigned Clinical Duties in Pediatric Hospitalist Fellowship and Training Programs
 PICUNICUAnesthesiaPrimary Care (Outpatient)Emergency DepartmentUrgent CareTransportGeneral Pediatric WardPediatric Subspecialty Ward 
AttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowOther Units
  • NOTE: Blank equals No. Abbreviations: Attd, attending; ICU, intensive care unit; NICU, neonatal ICU; PICU, pediatric ICU.

A Yes       Yes Yes YesYes   Newborn nursery
B              Yes    
C Yes Yes Yes   Yes   YesYesYes  Stepdown ICU
D Yes Yes Yes   Yes   YesYes    
E Yes   Yes   Yes    YesYes  Child abuse, newborn nursery, subacute care rehabilitation facility
F Yes Yes Yes       YesYesYes YesVariety of hospitals (county‐based)
G              Yes   Child abuse, consultation clinic, community‐based practice
H              Yes   Child abuse, consultation clinic, community‐based practice
I     Yes       YesYes  YesNewborn nursery

Pediatric Hospitalist Fellowship and Training Program Funding Sources

Five of the programs use department funds to finance the fellowship program. Four of the programs utilize the fellow or trainee's clinical work as a funding source. Two of the programs reported that the program is paid for through hospital funds.

Pediatric Hospitalist Fellow or Trainee Independence

Respondents indicated that fellows or trainees become increasingly independent over the course of the program. Fellows are supervised or mentored by hospitalists on staff. Half of the programs surveyed allow fellows or trainees to bill independently under certain circumstances (Table 7).

Independence in Pediatric Hospitalist Fellowship and Training Programs
 Bill Independently?Supervision?
ANo: bill under a supervising attendingSupervised by hospitalist and given autonomy with supervision from hospitalist attending.
BYesFirst couple of months during fellow's clinical period, more interaction with supervisors. Senior folks always available for consultation.
CYes: after 3 monthsClinical mentor (1 of 4 senior hospitalists) with whom they discuss patients on a more informal basis when on service.
DYes: on general wards, when functioning as attendingFellows meet weekly with fellowship director. Hospitalist on call available for consult.
EFellows: no; faculty fellows: yesTraditional fellowship role. Fellows complete several clinical electives with various levels of supervision.
FYes: after first 6 monthsFellows are supervised in their first year by hospitalist faculty.
GNoDay to day in patient care, senior staff review as needed. Each fellow has 1 primary supervisor. When on service overnight, fellows call staff attending.
HNoDay to day in patient care, senior staff review as needed. Each fellow has 1 primary supervisor. When on service overnight, fellows call staff attending.
IYesTrainees are supervised by the director of the hospitalist program, the inpatient attending, and other hospitalists.

DISCUSSION

There appear to be 2 distinct tracks for pediatric hospitalist training programs: clinical or academic specialization. However, this is not surprising, as most programs are relatively new and there are no standards or requirements for fellowship training from an external accrediting body. As such, the curriculum for these programs is likely driven by a combination of service requirements and local speculation on the needs of a future generation of pediatric hospitalists. Most programs also reported that they provide significant flexibility for each fellow based on their self‐perceived training needs and background.

Although there has been considerable emphasis on the potential educational role of hospitalists, formal coursework in teaching and education is not a part of the curriculum for half of the existing fellowship programs. Recent reports have demonstrated that hospitalists have received better teaching evaluations than traditional subspecialty attendings.7 However, this is in the absence of additional training in education and may reflect greater time that hospitalists might devote to their clinical trainees. The opportunity to further improve the educational training of hospitalists could be an important part of the fellowship experience.

Hospitalists have also been hypothesized to be in a prime position to either lead or have meaningful participation in quality improvement and cost‐saving efforts in the hospital setting. However, only half of programs provide formal coursework in QI and even fewer in areas of hospital economics.

Interestingly, most programs provide coursework in research methods, epidemiology, and grant writing. Requirements regarding clinical duties ranged from a minimum of 17% to a maximum of 67% of program time. It is unclear what the long‐term expectations in career achievement with regard to research will be for those physicians who spend the majority of their training time providing clinical care rather than in research. Previous authors have described the fallacy of expecting brief periods of coursework to prepare individuals for independent research careers.8 However, such coursework can certainly assist graduates of such programs to meaningfully participate in research projects and to put to valuable use their knowledge in both the educational and clinical aspects of their work. Though trainees enrolled in 1‐year programs will spend a larger proportion of their time providing clinical care based on program requirements, trainees in multiyear programs can choose to spend additional time performing clinical duties. Thus, 1 of the possible advantages of a 2‐year or 3‐year program may simply be the flexibility that the fellow has to tailor the program to his or her individual career goals.

Although previous studies have demonstrated that pediatric hospitalists may provide clinical service in a variety of hospital settings,2, 3, 911 most of the current fellowship programs do not provide extensive clinical experiences beyond the general pediatric ward. If hospitalists are to play a more comprehensive role in the care of the pediatric hospitalized patient, programs should consider expanding the scope of clinical training and exposure they provide.

The financial viability of hospitalist fellowship programs is also an important issue. If the additional training provided by these programs is felt to be of value to individual hospitals, it is likely that there will be an increase in the proportion of hospitals who wish to fund such training. A likely incentive for hospitals would be to position themselves to attract and retain hospitalists who possess a unique skill set for which they ascribe value for their patients and/or their bottom line.

Currently, in contrast to traditional, subspecialty‐based fellowships, half of the existing hospitalist fellowship programs allow hospitalist fellows to bill independently. This will have important implications both from an economic perspective, as well as relative to the perceptions of the degree of supervision provided by the respective training programs. This finding may also raise questions as to whether the need for additional clinical training after residency is really necessary to practice hospital medicine.

Whether the training and experience provided by these programs will be seen as a necessary precursor for careers in hospital medicine remains unknown. However, currently there appears to be a mismatch between what some hospitalists have identified as potential clinical educational needs6 with more than 50% desiring additional training in intensive care unit settings, and what is provided through the existing programs. In 2001, a survey of pediatric department chairs found that most did not believe additional formal training beyond residency was necessary to take on the role of a pediatric hospitalist.5 The value of pediatric hospitalist training programs may lie in their provision of or exposure to academic skill sets and the provision of administrative opportunities, in addition to targeted clinical training.

Potential Future Areas of Focus

The potential of a mismatch between education and practice or a training practice gap has been identified in internal medicine hospitalist training programs.12 To provide guidance to address this gap, Glasheen et al.13 assessed the spectrum and volume of specific diagnoses encountered in hospitals and the level of involvement of hospitalists in the care of these patients. They posit that training prioritized to the case mix expected to be encountered by hospitalists would be an appropriate concentration on which both tracked residency and fellowships could focus.

Of significant importance to many community physicians is the pattern of communication between hospitalists and the primary care physician of their patients. Recent reports have suggested this is a problem for many hospitalist programs.14 As such, it seems relevant that any hospitalist training program both develop a defined communication protocol and include instruction in physician‐to‐physician communication as a distinct part of their curriculum. Specifically, the importance of initial contact and timely discharge summaries should be addressed.

We did not explicitly ask respondents to discuss the scope of mentorship in their fellowship programs. However, based on respondents' descriptions of fellow or trainee supervision, we believe that the structure of mentorship programs likely varies across fellowships. Further study will be needed to determine the scope of mentorship in pediatric hospitalist training programs, and the impact of mentorship on training efficacy.

CONCLUSIONS

Pediatric hospitalist fellowship training programs are in the very early stages of their development. In time, greater structure across institutions will need to be put in place if they are to succeed in becoming a necessary prerequisite to the practice of hospital medicine. As the roles of hospitalists become more defined, the nature and extent of their advanced training needs will do so as well.

References
  1. Narang AS,Ey J.The emerging role of pediatric hospitalists.Clin Pediatr (Phila).2003;42(4):295297.
  2. Lye PS,Rauch DA,Ottolini MC, et al.Pediatric hospitalists: report of a leadership conference.Pediatrics.2006;117(4):11221130.
  3. Freed GL,Brzoznowski KF,Neighbors K,Lakhani I, The Research Advisory Committee of the American Board of Pediatrics.Characteristics of the pediatric hospitalist workforce: its roles and work environment.Pediatrics.2007;120:3339.
  4. Ranji SR,Rosenman DJ,Amin AN,Kripalani S.Hospital medicine fellowships: works in progress.Am J Med.2006;119:1.e11.e7.
  5. Srivastava R,Landrigan C,Gidwani P,Harary OH,Muret‐Wagstaff S,Homer CJ.Pediatric hospitalists in Canada and the United States: a survey of pediatric academic department chairs.Ambul Pediatr.2001;1:338339.
  6. Ottolini MC,Landrigan CP,Chiang VW,Stucky ER.PRIS Survey: pediatric hospitalist roles and training needs [Abstract].Pediatr Res.2004;55:360A.
  7. Geskey JM,Kees‐Folts D.Third‐year medical students' evaluation of hospitalist and nonhospitalist faculty during the inpatient portion of their pediatrics clerkships.J Hosp Med.2007;2(1):1722.
  8. Freed GL.Challenges in the development of pediatric health services research.J Pediatr.2002;140:12.
  9. Tenner PA,Dibrell H,Taylor RP.Improved survival with hospitalists in a pediatric intensive care unit.Crit Care Med.2003;31(3):847852.
  10. New study highlights ingredients for reengineering success.Health Care Cost Reengineering Rep.1999;4(5):7274,65.
  11. Carlson DW,Fentzke KM,Dawson JG.Pediatric hospitalists fill varied roles in the care of newborns.Pediatr Ann.2003;32(12):802810.
  12. Arora V,Guardiano S,Donaldson D,Storch I,Hemstreet P.Closing the gap between internal medicine training and practice: recommendations from recent graduates.Am J Med.2005;118(6):680685; discussion 685–687.
  13. Glasheen JJ,Epstein KR,Siegal E,Kutner JS,Prochazka AV.The spectrum of community‐based hospitalist practice: a call to tailor internal medicine residency training.Arch Intern Med.2007;167(7):727728.
  14. Kripalani S,LeFevre F,Phillips CO,Williams MV,Basaviah P,Baker DW.Deficits in communication and information transfer between hospital‐based and primary care physicians: implications for patient safety and continuity of care.JAMA.2007;297(8):831841.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
157-163
Legacy Keywords
fellowships, hospitalists, pediatric, teaching, training
Sections
Article PDF
Article PDF

The field of pediatric hospital medicine is undergoing rapid growth. In 2002, there were approximately 600 pediatric hospitalists1 and in 2006 this number was estimated to be approximately 1000.2 A recent study found that approximately 25% of pediatric hospitalist practices are less than 2 years old.3 As such, there are many new physicians entering the field and most do so without specific training in hospital medicine prior to beginning their employment.4 There is also significant variability in the roles, work patterns, and scope of practice across institutions,3 and hospitalists are engaged in a wide variety of clinical, educational, and administrative functions.

A survey of pediatric department chairs in 2001 found that very few believed that any additional training beyond a pediatric residency was required to perform hospitalist medicine.5 However, since then the field has undergone significant growth. A more recent survey of practicing hospitalists found that 92% believed there was a need for additional training in a variety of domains.6 Specifically, respondents were most interested in achieving greater skill in performing critical care procedures and academic training. These hospitalists regarded pediatric hospitalist fellowships as the best way to gain the additional skills in teaching, research, and administration needed for their positions.

Nonetheless, for a variety of reasons, not the least of which is perhaps the paucity of hospitalist fellowship training programs, few hospitalists in practice today have completed a fellowship in hospital medicine. Over the past several years, a number of pediatric‐specific hospitalist fellowship programs have been initiated, yet little is known of their requirements or curricula. We conducted a study to explore the structure, components, and training goals of the pediatric hospitalist fellowship programs in North America.

MATERIALS AND METHODS

Sample

To examine the characteristics of pediatric hospitalist training in North America, we examined all 8 fellowships or training programs that were in existence in early 2007. The total sample included the following sites: Children's Hospital Boston, Children's Specialists of San Diego, Children's National Medical Center, Children's Healthcare of Atlanta, Texas Children's Hospital, All Children's Hospital, University of North Carolina, and The Hospital for Sick Children.

Survey Instrument

We constructed a 17‐item structured questionnaire to be administered by phone. The instrument was designed to be completed in approximately 10 minutes. Questionnaire items focused on documenting the goals, training, requirements, and clinical duties that characterize current pediatric hospitalist training programs. The questionnaire was comprised of a mixture of fixed‐choice and open‐ended questions. A draft of the instrument was shared with representatives of the Society of Hospital Medicine Pediatrics Committee for comment and suggestions.

Questionnaire Administration

The research team sent a prenotification letter to directors of the 8 pediatric hospitalist training programs to inform them of the research study. From February through June 2007, research staff contacted the directors of the programs, explained the purpose of the study, and obtained verbal consent.

Data Analysis

Responses were reviewed to compare and contrast the characteristics of the various programs. The study was approved by the University of Michigan Medical Institutional Review Board.

RESULTS

Response Rate

Of the 8 training programs, all completed the survey, representing a response rate of 100%. One institution offers 2 separate fellowship paths: academic and clinical.

Pediatric Hospitalist Fellowship and Training Program Overview

The first pediatric hospital medicine fellowship was initiated 15 years ago. However, the majority of pediatric hospitalist training programs in North America were established more recently, between 2003 and 2007.

Most pediatric hospitalist training programs offer 1 position per year. The duration of the training programs range from 1 to 3 years. Minimum clinical duties required by the programs vary from 4 to 8 months and the maximum amount of clinical time permitted ranges from 4 to 20 months. Most programs indicated that there is some flexibility in the clinical duties required or available to the fellows.

Six of the 8 programs offer an academic degree. Table 1 provides an overview of the programs, types of degrees offered, and funding sources for academic work. Subsequent tables provide blinded results to protect respondent confidentiality.

Pediatric Hospital Medicine Fellowships and Training Programs in North America, 2007
ProgramYear EstablishedDivisionNumber of Positions, 2007Duration of ProgramMinimum Clinical TimeMaximum Clinical TimeDegree Possible?Who Pays for Degree?
  • Abbreviations: MAS, Master of Academic Sciences; MEd, Master of Education; MME, Master of Medical Education; MPH, Master of Public Health; MPP, Master of Public Policy; MS, Master of Science.

Toronto‐Academic1992Pediatric medicine32 years4 months4 monthsYes: fellow's choiceFellow
Children's Boston1998Emergency medicine12 years8 months12 monthsYes: MPH, MEd, MPPDepart. funds; Externalfunds (creative)
Children's National2003Hospital medicine1‐22‐3 years6 months20 monthsYes: MPHFaculty benefits
Children's Spec. San Diego2003Hospital medicine11‐2 years7 monthsNAYes: MASDivision
Toronto‐Clinical2004Pediatric medicine11 year8 months8 monthsNoNA
Texas2005Emergency medicine12 years8 months8 monthsYes: MPH, MMEVaries
University of North Carolina2006General pediatrics and adolescent medicine11 year5 months6 monthsNoNA
All Children's2007General pediatrics12 years8 months9 monthsYes: MPH, MSExternal funding pending (federal grants)
Children's Atlanta2007Pediatric hospitalist section11 year6 months6 monthsNoNA

The number of fellowship or training program positions available each year has remained fairly consistent. However, to date, enrollment has not kept up with position availability (Table 2).

Pediatric Hospital Medicine Fellowship and Training Program Availability and Enrollment
Program2006‐2007 Positions Available2006‐2007 Fellows Enrolled2007‐2008 Positions Available
ANANA1
B212
C111
DNANA1
E102
F101
G203
H121
I110

Program Goals

Seven out of 8 programs reported the provision of advanced training in the clinical care of hospitalized patients, quality improvement (QI), and hospital administration to be central goals of their training program. Six respondents reported the provision of training in the education of medical students and residents to be a primary goal of their program, while 5 indicated training in health services research to be a primary goal.

Participation in General Hospital Activities

Trainees in all programs participate in clinical care, resident education, student education, research activities, and hospital committees. Seven out of 8 programs reported that fellows or trainees participate in patient safety activities and guideline development.

Formal Training

Half of the programs reported that they provide formal coursework in areas of education and hospital administration including quality improvement, resident teaching, and student teaching. Three of the 8 programs provide formal coursework in hospital economics.

Three of the 8 programs provide seminars in resident teaching, student teaching, hospital economics, and leading a healthcare team (Table 3).

Formal Hospital Administration Training Provided by Pediatric Hospitalist Fellowship and Training Programs
ProgramsResident TeachingStudent TeachingHospital EconomicsQuality ImprovementLeading a Healthcare Team
CourseworkSeminarsCourseworkSeminarsCourseworkSeminarsCourseworkSeminarsCourseworkSeminars
  • NOTE: Blank equals No.

A Yes Yes YesYes   
BYes Yes Yes Yes Yes 
C    YesYesYesYes Yes
DYes Yes Yes Yes Yes 
E Yes Yes   Yes Yes
F     Yes    
GYesYesYesYes   Yes Yes
HYesYesYesYes   Yes Yes
IYes Yes       

Seven of 8 pediatric hospitalist training programs provide formal coursework in epidemiology and research methodology. Six programs reported that they provide formal coursework in biostatistics and 5 in publications or grant writing. Four offer seminars in health economics, research methodology, and QI methodology (Table 4).

Formal Research Training Provided by Pediatric Hospitalist Fellowship and Training Programs
 EpidemiologyBiostatisticsHealth EconomicsResearch MethodologyQI MethodologyPublications/Grant WritingTranslation ResearchEducational Research
CourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminar
  • NOTE: Blank equals No.

AYes Yes  YesYes  YesYes Yes Yes 
BYes Yes Yes Yes Yes YesYesYes Yes 
CYes Yes  YesYesYes Yes Yes    
DYes Yes  YesYes Yes Yes   Yes 
EYes Yes Yes YesYes Yes Yes    
FYes  Yes  YesYes  YesYes    
GYesYesYesYesYesYesYesYesYesYesYesYesYesYesYesYes
HYesYesYesYesYesYesYesYesYesYesYesYesYesYesYesYes
I                

Program Requirements

Seven pediatric hospitalist training programs require fellows to complete a research project. Six programs reported that they require fellows or trainees to complete a quality improvement project or participate on a hospital committee. Six of the programs require pediatric hospitalist fellows to attempt to present at a national meeting, and 4 programs require that fellows attempt to publish their research in a peer‐reviewed publication. Graduate degrees are required at 3 of the 8 pediatric hospitalist training programs (Table 5).

Fellowship or Training Program Requirements
 QI ProjectResearch ProjectAbstract/Presentation at National Meeting*Peer‐Reviewed Publication*Committee Participation at HospitalAttending on General Ward Leading Resident TeamSpecific Advanced Clinical TrainingGraduate Degree ProgramOther
  • NOTE: Blank equals No.

  • Required to try.

AYesYesYesYesYesYes Yes 
B Yes   Yes   
CYesYesYesYesYesYesYes  
DYesYesYes YesYesYes  
EYesYesYesYesYes YesYes 
FYesYesYesYesYesYesYes  
GYesYesYes    Yes 
H         
I    YesYesYes Journal club

Clinical Service Requirements

All programs indicated that they require the fellow or trainee to serve as an attending on the general pediatric ward. Five programs require the fellow or trainee to provide service at the fellow or PL‐3 level in the pediatric intensive care unit (PICU), anesthesia service, and transport team. Four programs reported that they require service in the emergency department, and 3 programs require service in the neonatal intensive care unit (NICU), newborn nursery, and general pediatric ward at the fellow or PL‐3 level. Only 2 programs require service in the pediatric subspecialty ward, and 1 program requires service in outpatient urgent care. No program requires primary care service (Table 6).

Assigned Clinical Duties in Pediatric Hospitalist Fellowship and Training Programs
 PICUNICUAnesthesiaPrimary Care (Outpatient)Emergency DepartmentUrgent CareTransportGeneral Pediatric WardPediatric Subspecialty Ward 
AttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowOther Units
  • NOTE: Blank equals No. Abbreviations: Attd, attending; ICU, intensive care unit; NICU, neonatal ICU; PICU, pediatric ICU.

A Yes       Yes Yes YesYes   Newborn nursery
B              Yes    
C Yes Yes Yes   Yes   YesYesYes  Stepdown ICU
D Yes Yes Yes   Yes   YesYes    
E Yes   Yes   Yes    YesYes  Child abuse, newborn nursery, subacute care rehabilitation facility
F Yes Yes Yes       YesYesYes YesVariety of hospitals (county‐based)
G              Yes   Child abuse, consultation clinic, community‐based practice
H              Yes   Child abuse, consultation clinic, community‐based practice
I     Yes       YesYes  YesNewborn nursery

Pediatric Hospitalist Fellowship and Training Program Funding Sources

Five of the programs use department funds to finance the fellowship program. Four of the programs utilize the fellow or trainee's clinical work as a funding source. Two of the programs reported that the program is paid for through hospital funds.

Pediatric Hospitalist Fellow or Trainee Independence

Respondents indicated that fellows or trainees become increasingly independent over the course of the program. Fellows are supervised or mentored by hospitalists on staff. Half of the programs surveyed allow fellows or trainees to bill independently under certain circumstances (Table 7).

Independence in Pediatric Hospitalist Fellowship and Training Programs
 Bill Independently?Supervision?
ANo: bill under a supervising attendingSupervised by hospitalist and given autonomy with supervision from hospitalist attending.
BYesFirst couple of months during fellow's clinical period, more interaction with supervisors. Senior folks always available for consultation.
CYes: after 3 monthsClinical mentor (1 of 4 senior hospitalists) with whom they discuss patients on a more informal basis when on service.
DYes: on general wards, when functioning as attendingFellows meet weekly with fellowship director. Hospitalist on call available for consult.
EFellows: no; faculty fellows: yesTraditional fellowship role. Fellows complete several clinical electives with various levels of supervision.
FYes: after first 6 monthsFellows are supervised in their first year by hospitalist faculty.
GNoDay to day in patient care, senior staff review as needed. Each fellow has 1 primary supervisor. When on service overnight, fellows call staff attending.
HNoDay to day in patient care, senior staff review as needed. Each fellow has 1 primary supervisor. When on service overnight, fellows call staff attending.
IYesTrainees are supervised by the director of the hospitalist program, the inpatient attending, and other hospitalists.

DISCUSSION

There appear to be 2 distinct tracks for pediatric hospitalist training programs: clinical or academic specialization. However, this is not surprising, as most programs are relatively new and there are no standards or requirements for fellowship training from an external accrediting body. As such, the curriculum for these programs is likely driven by a combination of service requirements and local speculation on the needs of a future generation of pediatric hospitalists. Most programs also reported that they provide significant flexibility for each fellow based on their self‐perceived training needs and background.

Although there has been considerable emphasis on the potential educational role of hospitalists, formal coursework in teaching and education is not a part of the curriculum for half of the existing fellowship programs. Recent reports have demonstrated that hospitalists have received better teaching evaluations than traditional subspecialty attendings.7 However, this is in the absence of additional training in education and may reflect greater time that hospitalists might devote to their clinical trainees. The opportunity to further improve the educational training of hospitalists could be an important part of the fellowship experience.

Hospitalists have also been hypothesized to be in a prime position to either lead or have meaningful participation in quality improvement and cost‐saving efforts in the hospital setting. However, only half of programs provide formal coursework in QI and even fewer in areas of hospital economics.

Interestingly, most programs provide coursework in research methods, epidemiology, and grant writing. Requirements regarding clinical duties ranged from a minimum of 17% to a maximum of 67% of program time. It is unclear what the long‐term expectations in career achievement with regard to research will be for those physicians who spend the majority of their training time providing clinical care rather than in research. Previous authors have described the fallacy of expecting brief periods of coursework to prepare individuals for independent research careers.8 However, such coursework can certainly assist graduates of such programs to meaningfully participate in research projects and to put to valuable use their knowledge in both the educational and clinical aspects of their work. Though trainees enrolled in 1‐year programs will spend a larger proportion of their time providing clinical care based on program requirements, trainees in multiyear programs can choose to spend additional time performing clinical duties. Thus, 1 of the possible advantages of a 2‐year or 3‐year program may simply be the flexibility that the fellow has to tailor the program to his or her individual career goals.

Although previous studies have demonstrated that pediatric hospitalists may provide clinical service in a variety of hospital settings,2, 3, 911 most of the current fellowship programs do not provide extensive clinical experiences beyond the general pediatric ward. If hospitalists are to play a more comprehensive role in the care of the pediatric hospitalized patient, programs should consider expanding the scope of clinical training and exposure they provide.

The financial viability of hospitalist fellowship programs is also an important issue. If the additional training provided by these programs is felt to be of value to individual hospitals, it is likely that there will be an increase in the proportion of hospitals who wish to fund such training. A likely incentive for hospitals would be to position themselves to attract and retain hospitalists who possess a unique skill set for which they ascribe value for their patients and/or their bottom line.

Currently, in contrast to traditional, subspecialty‐based fellowships, half of the existing hospitalist fellowship programs allow hospitalist fellows to bill independently. This will have important implications both from an economic perspective, as well as relative to the perceptions of the degree of supervision provided by the respective training programs. This finding may also raise questions as to whether the need for additional clinical training after residency is really necessary to practice hospital medicine.

Whether the training and experience provided by these programs will be seen as a necessary precursor for careers in hospital medicine remains unknown. However, currently there appears to be a mismatch between what some hospitalists have identified as potential clinical educational needs6 with more than 50% desiring additional training in intensive care unit settings, and what is provided through the existing programs. In 2001, a survey of pediatric department chairs found that most did not believe additional formal training beyond residency was necessary to take on the role of a pediatric hospitalist.5 The value of pediatric hospitalist training programs may lie in their provision of or exposure to academic skill sets and the provision of administrative opportunities, in addition to targeted clinical training.

Potential Future Areas of Focus

The potential of a mismatch between education and practice or a training practice gap has been identified in internal medicine hospitalist training programs.12 To provide guidance to address this gap, Glasheen et al.13 assessed the spectrum and volume of specific diagnoses encountered in hospitals and the level of involvement of hospitalists in the care of these patients. They posit that training prioritized to the case mix expected to be encountered by hospitalists would be an appropriate concentration on which both tracked residency and fellowships could focus.

Of significant importance to many community physicians is the pattern of communication between hospitalists and the primary care physician of their patients. Recent reports have suggested this is a problem for many hospitalist programs.14 As such, it seems relevant that any hospitalist training program both develop a defined communication protocol and include instruction in physician‐to‐physician communication as a distinct part of their curriculum. Specifically, the importance of initial contact and timely discharge summaries should be addressed.

We did not explicitly ask respondents to discuss the scope of mentorship in their fellowship programs. However, based on respondents' descriptions of fellow or trainee supervision, we believe that the structure of mentorship programs likely varies across fellowships. Further study will be needed to determine the scope of mentorship in pediatric hospitalist training programs, and the impact of mentorship on training efficacy.

CONCLUSIONS

Pediatric hospitalist fellowship training programs are in the very early stages of their development. In time, greater structure across institutions will need to be put in place if they are to succeed in becoming a necessary prerequisite to the practice of hospital medicine. As the roles of hospitalists become more defined, the nature and extent of their advanced training needs will do so as well.

The field of pediatric hospital medicine is undergoing rapid growth. In 2002, there were approximately 600 pediatric hospitalists1 and in 2006 this number was estimated to be approximately 1000.2 A recent study found that approximately 25% of pediatric hospitalist practices are less than 2 years old.3 As such, there are many new physicians entering the field and most do so without specific training in hospital medicine prior to beginning their employment.4 There is also significant variability in the roles, work patterns, and scope of practice across institutions,3 and hospitalists are engaged in a wide variety of clinical, educational, and administrative functions.

A survey of pediatric department chairs in 2001 found that very few believed that any additional training beyond a pediatric residency was required to perform hospitalist medicine.5 However, since then the field has undergone significant growth. A more recent survey of practicing hospitalists found that 92% believed there was a need for additional training in a variety of domains.6 Specifically, respondents were most interested in achieving greater skill in performing critical care procedures and academic training. These hospitalists regarded pediatric hospitalist fellowships as the best way to gain the additional skills in teaching, research, and administration needed for their positions.

Nonetheless, for a variety of reasons, not the least of which is perhaps the paucity of hospitalist fellowship training programs, few hospitalists in practice today have completed a fellowship in hospital medicine. Over the past several years, a number of pediatric‐specific hospitalist fellowship programs have been initiated, yet little is known of their requirements or curricula. We conducted a study to explore the structure, components, and training goals of the pediatric hospitalist fellowship programs in North America.

MATERIALS AND METHODS

Sample

To examine the characteristics of pediatric hospitalist training in North America, we examined all 8 fellowships or training programs that were in existence in early 2007. The total sample included the following sites: Children's Hospital Boston, Children's Specialists of San Diego, Children's National Medical Center, Children's Healthcare of Atlanta, Texas Children's Hospital, All Children's Hospital, University of North Carolina, and The Hospital for Sick Children.

Survey Instrument

We constructed a 17‐item structured questionnaire to be administered by phone. The instrument was designed to be completed in approximately 10 minutes. Questionnaire items focused on documenting the goals, training, requirements, and clinical duties that characterize current pediatric hospitalist training programs. The questionnaire was comprised of a mixture of fixed‐choice and open‐ended questions. A draft of the instrument was shared with representatives of the Society of Hospital Medicine Pediatrics Committee for comment and suggestions.

Questionnaire Administration

The research team sent a prenotification letter to directors of the 8 pediatric hospitalist training programs to inform them of the research study. From February through June 2007, research staff contacted the directors of the programs, explained the purpose of the study, and obtained verbal consent.

Data Analysis

Responses were reviewed to compare and contrast the characteristics of the various programs. The study was approved by the University of Michigan Medical Institutional Review Board.

RESULTS

Response Rate

Of the 8 training programs, all completed the survey, representing a response rate of 100%. One institution offers 2 separate fellowship paths: academic and clinical.

Pediatric Hospitalist Fellowship and Training Program Overview

The first pediatric hospital medicine fellowship was initiated 15 years ago. However, the majority of pediatric hospitalist training programs in North America were established more recently, between 2003 and 2007.

Most pediatric hospitalist training programs offer 1 position per year. The duration of the training programs range from 1 to 3 years. Minimum clinical duties required by the programs vary from 4 to 8 months and the maximum amount of clinical time permitted ranges from 4 to 20 months. Most programs indicated that there is some flexibility in the clinical duties required or available to the fellows.

Six of the 8 programs offer an academic degree. Table 1 provides an overview of the programs, types of degrees offered, and funding sources for academic work. Subsequent tables provide blinded results to protect respondent confidentiality.

Pediatric Hospital Medicine Fellowships and Training Programs in North America, 2007
ProgramYear EstablishedDivisionNumber of Positions, 2007Duration of ProgramMinimum Clinical TimeMaximum Clinical TimeDegree Possible?Who Pays for Degree?
  • Abbreviations: MAS, Master of Academic Sciences; MEd, Master of Education; MME, Master of Medical Education; MPH, Master of Public Health; MPP, Master of Public Policy; MS, Master of Science.

Toronto‐Academic1992Pediatric medicine32 years4 months4 monthsYes: fellow's choiceFellow
Children's Boston1998Emergency medicine12 years8 months12 monthsYes: MPH, MEd, MPPDepart. funds; Externalfunds (creative)
Children's National2003Hospital medicine1‐22‐3 years6 months20 monthsYes: MPHFaculty benefits
Children's Spec. San Diego2003Hospital medicine11‐2 years7 monthsNAYes: MASDivision
Toronto‐Clinical2004Pediatric medicine11 year8 months8 monthsNoNA
Texas2005Emergency medicine12 years8 months8 monthsYes: MPH, MMEVaries
University of North Carolina2006General pediatrics and adolescent medicine11 year5 months6 monthsNoNA
All Children's2007General pediatrics12 years8 months9 monthsYes: MPH, MSExternal funding pending (federal grants)
Children's Atlanta2007Pediatric hospitalist section11 year6 months6 monthsNoNA

The number of fellowship or training program positions available each year has remained fairly consistent. However, to date, enrollment has not kept up with position availability (Table 2).

Pediatric Hospital Medicine Fellowship and Training Program Availability and Enrollment
Program2006‐2007 Positions Available2006‐2007 Fellows Enrolled2007‐2008 Positions Available
ANANA1
B212
C111
DNANA1
E102
F101
G203
H121
I110

Program Goals

Seven out of 8 programs reported the provision of advanced training in the clinical care of hospitalized patients, quality improvement (QI), and hospital administration to be central goals of their training program. Six respondents reported the provision of training in the education of medical students and residents to be a primary goal of their program, while 5 indicated training in health services research to be a primary goal.

Participation in General Hospital Activities

Trainees in all programs participate in clinical care, resident education, student education, research activities, and hospital committees. Seven out of 8 programs reported that fellows or trainees participate in patient safety activities and guideline development.

Formal Training

Half of the programs reported that they provide formal coursework in areas of education and hospital administration including quality improvement, resident teaching, and student teaching. Three of the 8 programs provide formal coursework in hospital economics.

Three of the 8 programs provide seminars in resident teaching, student teaching, hospital economics, and leading a healthcare team (Table 3).

Formal Hospital Administration Training Provided by Pediatric Hospitalist Fellowship and Training Programs
ProgramsResident TeachingStudent TeachingHospital EconomicsQuality ImprovementLeading a Healthcare Team
CourseworkSeminarsCourseworkSeminarsCourseworkSeminarsCourseworkSeminarsCourseworkSeminars
  • NOTE: Blank equals No.

A Yes Yes YesYes   
BYes Yes Yes Yes Yes 
C    YesYesYesYes Yes
DYes Yes Yes Yes Yes 
E Yes Yes   Yes Yes
F     Yes    
GYesYesYesYes   Yes Yes
HYesYesYesYes   Yes Yes
IYes Yes       

Seven of 8 pediatric hospitalist training programs provide formal coursework in epidemiology and research methodology. Six programs reported that they provide formal coursework in biostatistics and 5 in publications or grant writing. Four offer seminars in health economics, research methodology, and QI methodology (Table 4).

Formal Research Training Provided by Pediatric Hospitalist Fellowship and Training Programs
 EpidemiologyBiostatisticsHealth EconomicsResearch MethodologyQI MethodologyPublications/Grant WritingTranslation ResearchEducational Research
CourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminarCourseSeminar
  • NOTE: Blank equals No.

AYes Yes  YesYes  YesYes Yes Yes 
BYes Yes Yes Yes Yes YesYesYes Yes 
CYes Yes  YesYesYes Yes Yes    
DYes Yes  YesYes Yes Yes   Yes 
EYes Yes Yes YesYes Yes Yes    
FYes  Yes  YesYes  YesYes    
GYesYesYesYesYesYesYesYesYesYesYesYesYesYesYesYes
HYesYesYesYesYesYesYesYesYesYesYesYesYesYesYesYes
I                

Program Requirements

Seven pediatric hospitalist training programs require fellows to complete a research project. Six programs reported that they require fellows or trainees to complete a quality improvement project or participate on a hospital committee. Six of the programs require pediatric hospitalist fellows to attempt to present at a national meeting, and 4 programs require that fellows attempt to publish their research in a peer‐reviewed publication. Graduate degrees are required at 3 of the 8 pediatric hospitalist training programs (Table 5).

Fellowship or Training Program Requirements
 QI ProjectResearch ProjectAbstract/Presentation at National Meeting*Peer‐Reviewed Publication*Committee Participation at HospitalAttending on General Ward Leading Resident TeamSpecific Advanced Clinical TrainingGraduate Degree ProgramOther
  • NOTE: Blank equals No.

  • Required to try.

AYesYesYesYesYesYes Yes 
B Yes   Yes   
CYesYesYesYesYesYesYes  
DYesYesYes YesYesYes  
EYesYesYesYesYes YesYes 
FYesYesYesYesYesYesYes  
GYesYesYes    Yes 
H         
I    YesYesYes Journal club

Clinical Service Requirements

All programs indicated that they require the fellow or trainee to serve as an attending on the general pediatric ward. Five programs require the fellow or trainee to provide service at the fellow or PL‐3 level in the pediatric intensive care unit (PICU), anesthesia service, and transport team. Four programs reported that they require service in the emergency department, and 3 programs require service in the neonatal intensive care unit (NICU), newborn nursery, and general pediatric ward at the fellow or PL‐3 level. Only 2 programs require service in the pediatric subspecialty ward, and 1 program requires service in outpatient urgent care. No program requires primary care service (Table 6).

Assigned Clinical Duties in Pediatric Hospitalist Fellowship and Training Programs
 PICUNICUAnesthesiaPrimary Care (Outpatient)Emergency DepartmentUrgent CareTransportGeneral Pediatric WardPediatric Subspecialty Ward 
AttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowAttdFellowOther Units
  • NOTE: Blank equals No. Abbreviations: Attd, attending; ICU, intensive care unit; NICU, neonatal ICU; PICU, pediatric ICU.

A Yes       Yes Yes YesYes   Newborn nursery
B              Yes    
C Yes Yes Yes   Yes   YesYesYes  Stepdown ICU
D Yes Yes Yes   Yes   YesYes    
E Yes   Yes   Yes    YesYes  Child abuse, newborn nursery, subacute care rehabilitation facility
F Yes Yes Yes       YesYesYes YesVariety of hospitals (county‐based)
G              Yes   Child abuse, consultation clinic, community‐based practice
H              Yes   Child abuse, consultation clinic, community‐based practice
I     Yes       YesYes  YesNewborn nursery

Pediatric Hospitalist Fellowship and Training Program Funding Sources

Five of the programs use department funds to finance the fellowship program. Four of the programs utilize the fellow or trainee's clinical work as a funding source. Two of the programs reported that the program is paid for through hospital funds.

Pediatric Hospitalist Fellow or Trainee Independence

Respondents indicated that fellows or trainees become increasingly independent over the course of the program. Fellows are supervised or mentored by hospitalists on staff. Half of the programs surveyed allow fellows or trainees to bill independently under certain circumstances (Table 7).

Independence in Pediatric Hospitalist Fellowship and Training Programs
 Bill Independently?Supervision?
ANo: bill under a supervising attendingSupervised by hospitalist and given autonomy with supervision from hospitalist attending.
BYesFirst couple of months during fellow's clinical period, more interaction with supervisors. Senior folks always available for consultation.
CYes: after 3 monthsClinical mentor (1 of 4 senior hospitalists) with whom they discuss patients on a more informal basis when on service.
DYes: on general wards, when functioning as attendingFellows meet weekly with fellowship director. Hospitalist on call available for consult.
EFellows: no; faculty fellows: yesTraditional fellowship role. Fellows complete several clinical electives with various levels of supervision.
FYes: after first 6 monthsFellows are supervised in their first year by hospitalist faculty.
GNoDay to day in patient care, senior staff review as needed. Each fellow has 1 primary supervisor. When on service overnight, fellows call staff attending.
HNoDay to day in patient care, senior staff review as needed. Each fellow has 1 primary supervisor. When on service overnight, fellows call staff attending.
IYesTrainees are supervised by the director of the hospitalist program, the inpatient attending, and other hospitalists.

DISCUSSION

There appear to be 2 distinct tracks for pediatric hospitalist training programs: clinical or academic specialization. However, this is not surprising, as most programs are relatively new and there are no standards or requirements for fellowship training from an external accrediting body. As such, the curriculum for these programs is likely driven by a combination of service requirements and local speculation on the needs of a future generation of pediatric hospitalists. Most programs also reported that they provide significant flexibility for each fellow based on their self‐perceived training needs and background.

Although there has been considerable emphasis on the potential educational role of hospitalists, formal coursework in teaching and education is not a part of the curriculum for half of the existing fellowship programs. Recent reports have demonstrated that hospitalists have received better teaching evaluations than traditional subspecialty attendings.7 However, this is in the absence of additional training in education and may reflect greater time that hospitalists might devote to their clinical trainees. The opportunity to further improve the educational training of hospitalists could be an important part of the fellowship experience.

Hospitalists have also been hypothesized to be in a prime position to either lead or have meaningful participation in quality improvement and cost‐saving efforts in the hospital setting. However, only half of programs provide formal coursework in QI and even fewer in areas of hospital economics.

Interestingly, most programs provide coursework in research methods, epidemiology, and grant writing. Requirements regarding clinical duties ranged from a minimum of 17% to a maximum of 67% of program time. It is unclear what the long‐term expectations in career achievement with regard to research will be for those physicians who spend the majority of their training time providing clinical care rather than in research. Previous authors have described the fallacy of expecting brief periods of coursework to prepare individuals for independent research careers.8 However, such coursework can certainly assist graduates of such programs to meaningfully participate in research projects and to put to valuable use their knowledge in both the educational and clinical aspects of their work. Though trainees enrolled in 1‐year programs will spend a larger proportion of their time providing clinical care based on program requirements, trainees in multiyear programs can choose to spend additional time performing clinical duties. Thus, 1 of the possible advantages of a 2‐year or 3‐year program may simply be the flexibility that the fellow has to tailor the program to his or her individual career goals.

Although previous studies have demonstrated that pediatric hospitalists may provide clinical service in a variety of hospital settings,2, 3, 911 most of the current fellowship programs do not provide extensive clinical experiences beyond the general pediatric ward. If hospitalists are to play a more comprehensive role in the care of the pediatric hospitalized patient, programs should consider expanding the scope of clinical training and exposure they provide.

The financial viability of hospitalist fellowship programs is also an important issue. If the additional training provided by these programs is felt to be of value to individual hospitals, it is likely that there will be an increase in the proportion of hospitals who wish to fund such training. A likely incentive for hospitals would be to position themselves to attract and retain hospitalists who possess a unique skill set for which they ascribe value for their patients and/or their bottom line.

Currently, in contrast to traditional, subspecialty‐based fellowships, half of the existing hospitalist fellowship programs allow hospitalist fellows to bill independently. This will have important implications both from an economic perspective, as well as relative to the perceptions of the degree of supervision provided by the respective training programs. This finding may also raise questions as to whether the need for additional clinical training after residency is really necessary to practice hospital medicine.

Whether the training and experience provided by these programs will be seen as a necessary precursor for careers in hospital medicine remains unknown. However, currently there appears to be a mismatch between what some hospitalists have identified as potential clinical educational needs6 with more than 50% desiring additional training in intensive care unit settings, and what is provided through the existing programs. In 2001, a survey of pediatric department chairs found that most did not believe additional formal training beyond residency was necessary to take on the role of a pediatric hospitalist.5 The value of pediatric hospitalist training programs may lie in their provision of or exposure to academic skill sets and the provision of administrative opportunities, in addition to targeted clinical training.

Potential Future Areas of Focus

The potential of a mismatch between education and practice or a training practice gap has been identified in internal medicine hospitalist training programs.12 To provide guidance to address this gap, Glasheen et al.13 assessed the spectrum and volume of specific diagnoses encountered in hospitals and the level of involvement of hospitalists in the care of these patients. They posit that training prioritized to the case mix expected to be encountered by hospitalists would be an appropriate concentration on which both tracked residency and fellowships could focus.

Of significant importance to many community physicians is the pattern of communication between hospitalists and the primary care physician of their patients. Recent reports have suggested this is a problem for many hospitalist programs.14 As such, it seems relevant that any hospitalist training program both develop a defined communication protocol and include instruction in physician‐to‐physician communication as a distinct part of their curriculum. Specifically, the importance of initial contact and timely discharge summaries should be addressed.

We did not explicitly ask respondents to discuss the scope of mentorship in their fellowship programs. However, based on respondents' descriptions of fellow or trainee supervision, we believe that the structure of mentorship programs likely varies across fellowships. Further study will be needed to determine the scope of mentorship in pediatric hospitalist training programs, and the impact of mentorship on training efficacy.

CONCLUSIONS

Pediatric hospitalist fellowship training programs are in the very early stages of their development. In time, greater structure across institutions will need to be put in place if they are to succeed in becoming a necessary prerequisite to the practice of hospital medicine. As the roles of hospitalists become more defined, the nature and extent of their advanced training needs will do so as well.

References
  1. Narang AS,Ey J.The emerging role of pediatric hospitalists.Clin Pediatr (Phila).2003;42(4):295297.
  2. Lye PS,Rauch DA,Ottolini MC, et al.Pediatric hospitalists: report of a leadership conference.Pediatrics.2006;117(4):11221130.
  3. Freed GL,Brzoznowski KF,Neighbors K,Lakhani I, The Research Advisory Committee of the American Board of Pediatrics.Characteristics of the pediatric hospitalist workforce: its roles and work environment.Pediatrics.2007;120:3339.
  4. Ranji SR,Rosenman DJ,Amin AN,Kripalani S.Hospital medicine fellowships: works in progress.Am J Med.2006;119:1.e11.e7.
  5. Srivastava R,Landrigan C,Gidwani P,Harary OH,Muret‐Wagstaff S,Homer CJ.Pediatric hospitalists in Canada and the United States: a survey of pediatric academic department chairs.Ambul Pediatr.2001;1:338339.
  6. Ottolini MC,Landrigan CP,Chiang VW,Stucky ER.PRIS Survey: pediatric hospitalist roles and training needs [Abstract].Pediatr Res.2004;55:360A.
  7. Geskey JM,Kees‐Folts D.Third‐year medical students' evaluation of hospitalist and nonhospitalist faculty during the inpatient portion of their pediatrics clerkships.J Hosp Med.2007;2(1):1722.
  8. Freed GL.Challenges in the development of pediatric health services research.J Pediatr.2002;140:12.
  9. Tenner PA,Dibrell H,Taylor RP.Improved survival with hospitalists in a pediatric intensive care unit.Crit Care Med.2003;31(3):847852.
  10. New study highlights ingredients for reengineering success.Health Care Cost Reengineering Rep.1999;4(5):7274,65.
  11. Carlson DW,Fentzke KM,Dawson JG.Pediatric hospitalists fill varied roles in the care of newborns.Pediatr Ann.2003;32(12):802810.
  12. Arora V,Guardiano S,Donaldson D,Storch I,Hemstreet P.Closing the gap between internal medicine training and practice: recommendations from recent graduates.Am J Med.2005;118(6):680685; discussion 685–687.
  13. Glasheen JJ,Epstein KR,Siegal E,Kutner JS,Prochazka AV.The spectrum of community‐based hospitalist practice: a call to tailor internal medicine residency training.Arch Intern Med.2007;167(7):727728.
  14. Kripalani S,LeFevre F,Phillips CO,Williams MV,Basaviah P,Baker DW.Deficits in communication and information transfer between hospital‐based and primary care physicians: implications for patient safety and continuity of care.JAMA.2007;297(8):831841.
References
  1. Narang AS,Ey J.The emerging role of pediatric hospitalists.Clin Pediatr (Phila).2003;42(4):295297.
  2. Lye PS,Rauch DA,Ottolini MC, et al.Pediatric hospitalists: report of a leadership conference.Pediatrics.2006;117(4):11221130.
  3. Freed GL,Brzoznowski KF,Neighbors K,Lakhani I, The Research Advisory Committee of the American Board of Pediatrics.Characteristics of the pediatric hospitalist workforce: its roles and work environment.Pediatrics.2007;120:3339.
  4. Ranji SR,Rosenman DJ,Amin AN,Kripalani S.Hospital medicine fellowships: works in progress.Am J Med.2006;119:1.e11.e7.
  5. Srivastava R,Landrigan C,Gidwani P,Harary OH,Muret‐Wagstaff S,Homer CJ.Pediatric hospitalists in Canada and the United States: a survey of pediatric academic department chairs.Ambul Pediatr.2001;1:338339.
  6. Ottolini MC,Landrigan CP,Chiang VW,Stucky ER.PRIS Survey: pediatric hospitalist roles and training needs [Abstract].Pediatr Res.2004;55:360A.
  7. Geskey JM,Kees‐Folts D.Third‐year medical students' evaluation of hospitalist and nonhospitalist faculty during the inpatient portion of their pediatrics clerkships.J Hosp Med.2007;2(1):1722.
  8. Freed GL.Challenges in the development of pediatric health services research.J Pediatr.2002;140:12.
  9. Tenner PA,Dibrell H,Taylor RP.Improved survival with hospitalists in a pediatric intensive care unit.Crit Care Med.2003;31(3):847852.
  10. New study highlights ingredients for reengineering success.Health Care Cost Reengineering Rep.1999;4(5):7274,65.
  11. Carlson DW,Fentzke KM,Dawson JG.Pediatric hospitalists fill varied roles in the care of newborns.Pediatr Ann.2003;32(12):802810.
  12. Arora V,Guardiano S,Donaldson D,Storch I,Hemstreet P.Closing the gap between internal medicine training and practice: recommendations from recent graduates.Am J Med.2005;118(6):680685; discussion 685–687.
  13. Glasheen JJ,Epstein KR,Siegal E,Kutner JS,Prochazka AV.The spectrum of community‐based hospitalist practice: a call to tailor internal medicine residency training.Arch Intern Med.2007;167(7):727728.
  14. Kripalani S,LeFevre F,Phillips CO,Williams MV,Basaviah P,Baker DW.Deficits in communication and information transfer between hospital‐based and primary care physicians: implications for patient safety and continuity of care.JAMA.2007;297(8):831841.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
157-163
Page Number
157-163
Article Type
Display Headline
Characteristics of pediatric hospital medicine fellowships and training programs
Display Headline
Characteristics of pediatric hospital medicine fellowships and training programs
Legacy Keywords
fellowships, hospitalists, pediatric, teaching, training
Legacy Keywords
fellowships, hospitalists, pediatric, teaching, training
Sections
Article Source

Copyright © 2009 Society of Hospital Medicine

Disallow All Ads
Correspondence Location
University of Michigan, 300 North Ingalls Building 6E08, Ann Arbor, MI 48109‐0456
Content Gating
No Gating (article Unlocked/Free)
Alternative CME
Article PDF Media

Oseltamivir in Children with CA‐LCI

Article Type
Changed
Sun, 05/28/2017 - 21:48
Display Headline
Treatment with oseltamivir in children hospitalized with community‐acquired, laboratory‐confirmed influenza: Review of five seasons and evaluation of an electronic reminder

Influenza is a common cause of acute respiratory illness in children, resulting in hospitalization of both healthy and chronically ill children due to influenza‐related complications.1, 2 Currently, amantadine, rimantadine, oseltamivir, and zanamivir are approved for use in children to treat influenza. In early 2006, more than 90% of influenza isolates tested in the US were found to be resistant to the adamantanes, suggesting that these medications might be of limited benefit during future influenza seasons.3 To date, most isolates of influenza remain susceptible to neuraminidase inhibitors, zanamivir and oseltamivir. Zanamivir has not been used extensively in pediatrics because it is delivered by aerosolization, and is only approved by the US Food and Drug Administration (FDA) for children 7 years of age. Oseltamivir is administered orally and is FDA‐approved for use in children 1 year of age within 48 hours of onset of symptoms of influenza virus infection.

Studies performed in outpatient settings have shown that oseltamivir can lessen the severity and reduce the length of influenza illness by 36 hours when therapy is initiated within 2 days of the onset of symptoms.4 Treatment also reduced the frequency of new diagnoses of otitis media and decreased physician‐prescribed antibiotics.4

To date, there are limited data evaluating the use of oseltamivir in either adult or pediatric patients hospitalized with influenza. We sought to describe the use of antiviral medications among children hospitalized with community‐acquired laboratory‐confirmed influenza (CA‐LCI) and to evaluate the effect of a computer‐based electronic reminder to increase the rate of on‐label use of oseltamivir among hospitalized children.

PATIENTS AND METHODS

We performed a retrospective cohort study of patients 21 years of age who were hospitalized with CA‐LCI during 5 consecutive seasons from July 2000 through June 2005 (seasons 1‐5) at the Children's Hospital of Philadelphia (CHOP). CHOP is a 418‐bed tertiary care hospital with about 24,000 hospital admissions each year. Viral diagnostic studies are performed routinely on children hospitalized with acute respiratory symptoms of unknown etiology, which aids in assigning patients to cohorts. Patients who had laboratory confirmation of influenza performed at an outside institution were excluded from this analysis.

From June 2005 through May 2006 (season 6), an observational trial of an electronic clinical decision reminder was performed to assess a mechanism to increase the proportion of eligible children treated with oseltamivir. Patients were included in this analysis if they were 21 years of age and had a diagnostic specimen for influenza obtained less than 72 hours after admission. The CHOP Institutional Review Board approved this study with a waiver of informed consent.

Viral Diagnostic Testing

During the winter months from seasons 1‐5, nasopharyngeal aspirate specimens were initially tested using immunochromatographic membrane assays (IA) for respiratory syncytial virus (RSV) (NOW RSV; Binax, Inc., Scarborough, ME) and, if negative, for influenza virus types A and B (NOW Flu A, NOW Flu B; Binax). If negative, specimens were tested by direct fluorescent antibody (DFA) testing for multiple respiratory viruses, including influenza A and B. During the winter season, IA testing was performed multiple times each day, and DFA was performed once or twice daily with an 8 to 24 hour turnaround time after a specimen was obtained. For season 6, the testing algorithm was revised: a panel of real‐time polymerase chain reaction (PCR) assays were performed to detect nucleic acids from multiple respiratory viruses, including influenza virus types A and B, on specimens that tested negative for influenza and RSV by IA. PCR testing was performed multiple times each day, and specimen results were available within 24 hours of specimen submission. Comprehensive viral tube cultures were performed on specimens that were negative by IA and DFA (seasons 1‐5) or respiratory virus PCR panel (season 6).

Study Definitions

Patients were considered to have CA‐LCI if the first diagnostic specimen positive for influenza was obtained less than 72 hours after hospital admission. Prescriptions for oseltamivir that were consistent with the FDA recommendations were considered to be on‐label prescriptions. Prescriptions for oseltamivir given to patients who did not meet these FDA criteria were considered off‐label prescriptions.5 Patients were considered oseltamivir‐eligible if they were met the criteria for FDA approval for treatment with oseltamivir: at least 1 year of age with influenza symptoms of less than 48 hours duration. Patients who either by age and/or symptom duration were inconsistent with FDA labeling criteria for oseltamivir were deemed oseltamivir‐ineligible. This included those patients for whom influenza test results were received by the clinician more than 48 hours after symptom onset. Patients who were positive for influenza only by viral culture were considered oseltamivir‐ineligible since the time needed to culture influenza virus was >48 hours. Because of the abrupt onset of influenza symptoms, the duration of influenza symptoms was defined by chart review of the emergency room or admission note. A hierarchy of symptoms was used to define the initial onset of influenza‐related symptoms and include the following: (1) For all patients with a history of fever, onset of influenza was defined as the onset of fever as recorded in the first physician note. (2) For patients without a history of fever, the onset of respiratory symptoms was recorded as the onset of influenza. (3) For patients without a history of fever but in whom multiple respiratory symptoms were noted, the onset of symptoms was assigned as the beginning of the increased work of breathing.

Because influenza IA were performed at least 4 times a day during the influenza season, the date of result to clinician was determined to be the same date as specimen collection for patients who had a positive influenza IA. Patients were identified as having a positive influenza result to the clinician 1 day after specimen collection if the test was positive by DFA or PCR. A neurologic adverse event was defined as the occurrence of a seizure after initiation of oseltamivir therapy. A neuropsychiatric adverse event was defined as any significant new neuropsychiatric symptom (psychosis, encephalopathy) recorded after the initiation of oseltamivir therapy. We defined a dermatologic adverse event as the report of any skin findings recorded after the initiation of oseltamivir therapy.

Chronic medical conditions

Information from detailed chart review was used to identify children with Advisory Committee on Immunization Practices (ACIP) high‐risk medical conditions as previously described by our group (asthma, chronic pulmonary disease, cardiac disease, immunosuppression, hemoglobinopathies, chronic renal dysfunction, diabetes mellitus, inborn errors of metabolism, long‐term salicylate therapy, pregnancy, and neurological and neuromuscular disease [NNMD]).6

Electronic Reminder

During season 6, a computer‐based electronic reminder was designed. The reminder stated Consider OSELTAMIVIR if Age >1 year AND symptoms <48 hours. May shorten illness by 36 hours. Page ID approval for more info. The reminder was embedded within the influenza results for all positive determinations, so a clinician would see the reminder when viewing positive laboratory results (Meditech, Westwood, MA).

At the initiation of season 6, we determined prescription rates of oseltamivir in patients with CA‐LCI to measure the baseline rate of oseltamivir prescription. The electronic reminder was initiated during week 11 of influenza activity at our institution and continued through the end of the influenza season.

Data Collection

Two sources of antiviral prescription data were used. Inpatient prescription of antiviral medications was extracted from billing records and chart review; a 10% audit of the medication administration records showed that the billing records correctly identified oseltamivir prescription status in all cases reviewed. Patients with incomplete pharmacy data were removed from the analysis of prescription practices (n = 8). During all seasons studied, the infectious diseases pharmacist (T.A.M.) and an infectious diseases physician (T.E.Z.) reviewed requests for inpatient prescriptions for antiviral medications.

For season 6, daily review of infection control records was performed to conduct surveillance for children hospitalized with CA‐LCI. To determine symptom duration and use of antiviral medications, inpatient medical charts were reviewed at the time of initial identification and then daily thereafter.

Statistical Analysis

Dichotomous variables were created for prescription of oseltamivir, age 1 year and symptom duration of <48 hours at time of clinician receipt of influenza results. Descriptive analyses included calculating the frequencies for categorical variables. Categorical variables were compared using Fisher's exact test. The Cochrane‐Armitage test was employed to test for a trend in the prescription of oseltamivir by season. A 2‐tailed P value of <0.05 was considered significant for all statistical tests. All statistical calculations were performed using standard programs in SAS 9.1 (SAS Institute, Cary, NC), STATA 8.2 (Stata Corp., College Station, TX), and Excel (Microsoft, Redmond, WA).

Prior to the start of season 6, we determined that if the rate of oseltamivir prescription was 40% before initiation of the reminder, we would need 20 eligible patients to detect a difference of 40% or greater in subsequent prescription rates (with 80% power and an alpha of 0.05). Once this enrollment goal was met, an electronic reminder of the eligibility for oseltamivir was initiated.

RESULTS

Use of Antiviral Medications in Children Hospitalized with Influenza, 2000‐2005

From July 2000 to June 2005, 1,058 patients were admitted with laboratory confirmed influenza; 8 were excluded because confirmatory testing was done at an outside institution, 24 were repeat hospitalizations, 89 nosocomial cases, and 8 cases were in patients >21 years. Thus, 929 patients had CA‐LCI and were eligible for inclusion in this study. Most children were infected with influenza A and were 1 year of age (Table 1). During this study period, only 9.3% of study subjects were treated with antiviral medications, most of whom (91%) received oseltamivir. Eight patients received amantadine over all seasons studied.

Characteristics of Patients Hospitalized with CA‐LCI and Oseltamivir Eligibility During Five Influenza Seasons, 2000‐2001 to 2004‐2005
CharacteristicsPatients Hospitalized with CA‐LCI (n = 929)*Eligible to Receive Oseltamivir (n = 305)*
  • Values are number of patients (%).

Age (years)  
<1342 (37)0
1587 (63)305 (100)
Season  
2000‐2001107 (11.5)32 (10)
2001‐2002252 (27)78 (26)
2002‐2003135 (14.5)31 (10)
2003‐2004243 (26)86 (28)
2004‐2005192 (21)78 (26)
Influenza type  
A692 (75) 
B237 (25) 

Overall, one‐third of patients (305/929; 33%) were eligible for treatment with oseltamivir. Among patients 1 year of age, approximately one‐half (305/587; 52%) were oseltamivir‐eligible. The additional 282 patients 1 year were ineligible because test results were returned to the clinician >48 hours after hospital admission. Only 49 (16.1%) of oseltamivir‐eligible patients were prescribed oseltamivir during hospitalization (Figure 1). The rate of prescription of oseltamivir increased over all seasons from 0% in 2000‐2001 to 20% in 2004‐2005. On‐label prescription rates increased from 0% in 2000‐2001 to 37.2% in 2004‐2005 (P < 0.0001; Figure 2).

Figure 1
Study subjects: duration of symptoms, age, and treatment status.
Figure 2
Oseltamivir prescription rates among hospitalized children, 2000‐2005. Percent of eligible or ineligible patients treated with oseltamivir. A significant trend over time of oseltamivir use was found for both eligible and ineligible patients, by nonparametric (NP) trend test (P < 0.0001).

Off‐Label Oseltamivir Prescription

Oseltamivir was prescribed to 29 of the 624 patients who were determined to be oseltamivir‐ineligible. The rate of off‐label use increased over the seasons from 2000 to 2005 from 0% to 8.8% (P < 0.0001; Figure 1). Ineligible patients who received oseltamivir were 1 year of age (n = 11), had test results returned to the clinician 48 hours after hospital admission (n = 18), or both (n = 4). Most off‐label prescriptions occurred in patients who had chronic medical conditions (21/29; 72%), including cardiac disease (n = 9), asthma (n = 6), or prematurity (n = 5). Four of 11 patients 1 year of age who were treated with oseltamivir had influenza‐related respiratory failure. The oseltamivir dose for all patients 1 year of age was 2 mg/kg twice a day, all of whom survived to discharge.

Evaluation of a Computer‐Based Electronic Reminder Designed to Enhance the On‐Label Prescription of Oseltamivir

During season 6, an electronic reminder about the labeled use of oseltamivir was evaluated to determine its ability to increase the rate of prescription of oseltamivir among eligible children hospitalized with CA‐LCI. During season 6, most patients (226/311; 73%) were 1 year of age. A total of 84 patients were determined to be oseltamivir‐eligible (age 1 year and test results back to the clinician within 48 hours of symptom onset).

During the initial 10 weeks of local influenza activity, 20 oseltamivir‐eligible patients were admitted to our institution, and 8 received oseltamivir (40% prescription rate) (Table 2). In addition, 2 of 54 (3.7%) oseltamivir‐ineligible patients were also treated. The computer‐based electronic reminder was initiated in week 11 of the influenza season. After initiation of the reminder, 237 additional children with CA‐LCI were hospitalized, of whom 64 (27%) were determined to be oseltamivir‐eligible. The rate of on‐label prescription of oseltamivir was similar to that observed prior to initiation of the reminder: 16 of 64 patients eligible for antiviral therapy received oseltamivir (25% prescription rate) (Figure 3). An additional 8 patients were prescribed oseltamivir off‐label. The rate of oseltamivir prescription did not change significantly for either oseltamivir‐eligible (40‐25%) or oseltamivir‐ineligible (3.7‐4.6%) (Figure 4).

Figure 3
Proportion of eligible patients who were treated with oseltamivir during the intervention season (2005‐2006). Two proportions represent proportions before and after activation of electronic prompt. No significant difference found in prescription of oseltamivir for those eligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).
Figure 4
Proportion of ineligible patients who were treated with oseltamivir during the intervention season (2005‐2006). Two proportions represent proportions before and after activation of electronic prompt. No significant difference found in prescription of oseltamivir for those ineligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).
Oseltamivir Eligibility and Use Among Patients Hospitalized with CA‐LCI During the Intervention Season, 2005‐2006
Prompt Active?Oseltamivir UseTotal
Yes*No
  • NOTE: No significant difference found in prescription of oseltamivir for those eligible and ineligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).

  • Values are number of patients (%).

  • Values are number of patients.

No   
Eligible8 (40)1220
Ineligible2 (3.7)5254
Yes   
Eligible16 (25)4864
Ineligible8 (4.6)165173
Total34277311

Dermatologic, Neurologic, and Neuropsychiatric Adverse Events

We reviewed the medical records of all patients treated with oseltamivir during the 6 study seasons to identify dermatologic, neurologic, and neuropsychiatric adverse outcomes that developed after the initiation of oseltamivir therapy. No new‐onset seizures, neuropsychiatric, or dermatologic reactions were identified among the children treated with oseltamivir.

DISCUSSION AND CONCLUSION

In this report, we describe the use of oseltamivir over 6 seasons in a cohort of children hospitalized with CA‐LCI at 1 tertiary care pediatric hospital and examine the impact of a mechanism designed to increase prescription among those eligible for oseltamivir. We found that only one‐third of patients hospitalized at our institution were eligible for oseltamivir treatment based on FDA‐approved indications. Of the eligible patients, few were prescribed oseltamivir during their hospitalization. During the sixth season, we employed a computer reminder system for oseltamivir prescription, which had no appreciable effect upon prescription rates. Despite the lack of effect of the electronic reminder system, we observed an increase of on‐label oseltamivir prescriptions over the entire study period. Finally, we identified 11 patients <1 year of age (3%) who were treated with oseltamivir. There were no adverse events identified in this group.

Although previous studies have addressed prescription rates of oseltamivir in children with influenza, few, if any, have looked at how these prescriptions correspond with FDA label criteria. In our cohort, only one‐third of hospitalized children were eligible for treatment with oseltamivir based upon their age and symptom duration at the time the results of rapid laboratory testing became available. Of those patients in our cohort eligible for oseltamivir, few were treated. The prescription of oseltamivir in seasons falls within the ranges found by Schrag et al.7 in their multistate review of pediatric influenza hospitalizations in 2003‐2004. They noted that use of antiviral medications varied by location of surveillance ranging from 3% in Connecticut to 34% in Colorado, indicating significant regional differences in prescription practices.7 Potential causes of low rates of appropriate use of oseltamivir include the observation that many physicians remain unaware of the potential severity of influenza infection in children.8 Additionally, physicians may differ on how to define the onset of influenza infection in children. A recent study published by Ohmit and Monto9 indicated that a fever and cough predicted 83% of children 5 to 12 years old who were determined to be influenza‐positive. Finally, many physicians who do not prescribe antiviral therapy may believe that their patients present too late for appropriate initiation of therapy.10

We identified 29 patients who received oseltamivir although they did not meet the FDA label criteria, of whom 72% had a chronic underlying condition. Moore et al.11 in their surveillance of influenza admissions in Canada found a similar trend. They described 26 of 29 (90%) hospitalized patients receiving antiinfluenza drugs had an underlying disease, and of those without a chronic condition, all had severe influenza‐related complications such as encephalopathy.11

Implementation of a computerized reminder to improve use of oseltamivir had no statistically significant effect on prescribing practice. Our sample size calculation was based on detecting a 40% difference in prescription rates, which limited our power to detect a smaller difference in prescription rates. A systematic review by Garg et al.12 identified barriers to the success of computer‐based decision support systems (CDS), which included failure of practitioners to use the system, poor integration of the system to the physician's workflow, and disagreement with what was recommended. Future enhancements to our inpatient electronic hospital record may allow for more targeted and robust CDS interventions.

We observed an increase in on‐label prescription rates of oseltamivir over the entire study period. We hypothesize that increased use of oseltamivir might be associated with growing concerns of pandemic influenza and attention to fatal influenza in children,13 as evidenced by the recent addition of influenza‐associated deaths in children to the list of nationally notifiable conditions in 2004.14

There has been considerable focus upon potential adverse events associated with treatment with oseltamivir in children. Reports have emerged, primarily from Japan, of neuropsychiatric and dermatologic adverse events of oseltamivir treatment.15 In the fall of 2006, the FDA added a precaution to the labeling of oseltamivir due to these neuropsychiatric events.16 In our treated cohort, no neurologic, neuropsychiatric, or dermatologic adverse events were identified. However, this finding is not surprising given the rarity of these adverse events and the limited number of children treated with oseltamivir in this study.

The strengths of this current study include a large cohort of laboratory‐confirmed influenza in hospitalized children over multiple influenza seasons. In addition, this is the first study of which we are aware that has assessed the number of children eligible for oseltamivir but not treated. The limitations of this study include misclassification bias related to the retrospective study design. Because of this design, onset of influenza symptoms was collected through chart review, and the time of receipt of influenza results from virology was based upon known laboratory turnover time, rather than actual knowledge of time of physician awareness of the result. To address this issue we used a conservative estimate of the time of receipt of influenza test results. In addition, the retrospective design prevented us from assessing the clinical decision‐making process, which led some patients to be treated with oseltamivir and others not. Our evaluation of the electronic reminder was designed to show a large change in prescription practices (ie, 40%), so it had insufficient power to detect a smaller impact. Finally, ascertainment bias may have limited our ability to identify adverse effects.

This study demonstrates that oseltamivir is prescribed infrequently among hospitalized children. Future studies are needed to determine whether appropriate use of oseltamivir improves outcomes among hospitalized children. Additional study of the safety and efficacy of oseltamivir in children aged <1 year is also needed given the large burden of disease in this age group.

Acknowledgements

We thank Michelle Precourt for her assistance with the computer‐based prompt. We also thank Drs. Anna Wheeler Rosenquist and Melissa Donovan for the original data collection for this project. This project was supported in part by the Centers for Disease Control and Prevention, grant H23/CCH32253‐02.

References
  1. Izurieta HS,Thompson WW,Kramarz P, et al.Influenza and the rates of hospitalization for respiratory disease among infants and young children.N Engl J Med.2000;342:232239.
  2. Neuzil KM,Mellen BG,Wright PF,Mitchel EF,Griffin MR.The effect of influenza on hospitalizations, outpatient visits and courses of antibiotics in children.N Engl J Med.2000;342:225231.
  3. Centers for Disease Control and Prevention (CDC). Diseases and Conditions. Seasonal Flu. CDC Health Alert: CDC recommends against the use of amantadine and rimantadine for the treatment or prophylaxis of influenza in the United States during the 2005–06 influenza season. January 14, 2006. Available at http://www.cdc.gov/flu/han011406.htm. Accessed November2008.
  4. Whitley RJ,Hayden FG,Reisinger KS, et al.Oral oseltamivir treatment of influenza in children.Pediatr Infect Dis J.2001;20(2):127133.
  5. Shah S,Hall M,Goodman DM, et al.Off‐label drug use in hospitalized children.Arch Pediatr Adolesc Med.2007;161(3):282290.
  6. Keren R,Zaoutis TE,Bridges CB, et al.Neurological and neuromuscular disease as a risk factor for respiratory failure in children hospitalized with influenza infection.JAMA.2005;294:21882194.
  7. Schrag SJ,Shay DK,Gershman K, et al.Multistate surveillance for laboratory‐confirmed influenza‐associated hospitalizations in children 2003–2004.Pediatr Infect Dis J.2006;25(5):395400.
  8. Dominguez SR,Daum RS.Physician knowledge and perspectives regarding influenza and influenza vaccination.Hum Vaccin.2005;1(2):7479.
  9. Ohmit SE,Monto AS.Symptomatic predictors of influenza virus positivity in children during the influenza season.Clin Infect Dis.2006;43:564568.
  10. Rothberg MB,Bonner AB,Rajab MH,Kim HS,Stechenberg BW,Rose DN.Effects of local variation, specialty, and beliefs on antiviral prescribing for influenza.Clin Infect Dis.2006;42:9599.
  11. Moore DL,Vaudry W,Scheifele DW, et al.Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003–2004.Pediatrics.2006;118:e610e619.
  12. Garg AX,Adhikari NK,McDonald H, et al.Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review.JAMA.2005;293:12231238.
  13. Bhat N,Wright JG,Broder KR, et al.Influenza‐associated deaths among children in the United States, 2003–2004.N Engl J Med.2005;353(24):25592567.
  14. Centers for Disease Control and Prevention (CDC). Diseases and Conditions. Seasonal Flu. Flu Activity 25(6):572.
  15. Edwards ET,Truffa MM,Mosholder AD.Post‐Marketing Adverse Event Reports. Review of Central Nervous System/Psychiatric Disorders Associated with the Use of Tamiflu, Drug: Oseltamivir Phosphate. Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology.2006. OSE PID #D060393 Oseltamivir—Neuropsychiatric Events.
Article PDF
Issue
Journal of Hospital Medicine - 4(3)
Page Number
171-178
Legacy Keywords
children, influenza, oseltamivir
Sections
Article PDF
Article PDF

Influenza is a common cause of acute respiratory illness in children, resulting in hospitalization of both healthy and chronically ill children due to influenza‐related complications.1, 2 Currently, amantadine, rimantadine, oseltamivir, and zanamivir are approved for use in children to treat influenza. In early 2006, more than 90% of influenza isolates tested in the US were found to be resistant to the adamantanes, suggesting that these medications might be of limited benefit during future influenza seasons.3 To date, most isolates of influenza remain susceptible to neuraminidase inhibitors, zanamivir and oseltamivir. Zanamivir has not been used extensively in pediatrics because it is delivered by aerosolization, and is only approved by the US Food and Drug Administration (FDA) for children 7 years of age. Oseltamivir is administered orally and is FDA‐approved for use in children 1 year of age within 48 hours of onset of symptoms of influenza virus infection.

Studies performed in outpatient settings have shown that oseltamivir can lessen the severity and reduce the length of influenza illness by 36 hours when therapy is initiated within 2 days of the onset of symptoms.4 Treatment also reduced the frequency of new diagnoses of otitis media and decreased physician‐prescribed antibiotics.4

To date, there are limited data evaluating the use of oseltamivir in either adult or pediatric patients hospitalized with influenza. We sought to describe the use of antiviral medications among children hospitalized with community‐acquired laboratory‐confirmed influenza (CA‐LCI) and to evaluate the effect of a computer‐based electronic reminder to increase the rate of on‐label use of oseltamivir among hospitalized children.

PATIENTS AND METHODS

We performed a retrospective cohort study of patients 21 years of age who were hospitalized with CA‐LCI during 5 consecutive seasons from July 2000 through June 2005 (seasons 1‐5) at the Children's Hospital of Philadelphia (CHOP). CHOP is a 418‐bed tertiary care hospital with about 24,000 hospital admissions each year. Viral diagnostic studies are performed routinely on children hospitalized with acute respiratory symptoms of unknown etiology, which aids in assigning patients to cohorts. Patients who had laboratory confirmation of influenza performed at an outside institution were excluded from this analysis.

From June 2005 through May 2006 (season 6), an observational trial of an electronic clinical decision reminder was performed to assess a mechanism to increase the proportion of eligible children treated with oseltamivir. Patients were included in this analysis if they were 21 years of age and had a diagnostic specimen for influenza obtained less than 72 hours after admission. The CHOP Institutional Review Board approved this study with a waiver of informed consent.

Viral Diagnostic Testing

During the winter months from seasons 1‐5, nasopharyngeal aspirate specimens were initially tested using immunochromatographic membrane assays (IA) for respiratory syncytial virus (RSV) (NOW RSV; Binax, Inc., Scarborough, ME) and, if negative, for influenza virus types A and B (NOW Flu A, NOW Flu B; Binax). If negative, specimens were tested by direct fluorescent antibody (DFA) testing for multiple respiratory viruses, including influenza A and B. During the winter season, IA testing was performed multiple times each day, and DFA was performed once or twice daily with an 8 to 24 hour turnaround time after a specimen was obtained. For season 6, the testing algorithm was revised: a panel of real‐time polymerase chain reaction (PCR) assays were performed to detect nucleic acids from multiple respiratory viruses, including influenza virus types A and B, on specimens that tested negative for influenza and RSV by IA. PCR testing was performed multiple times each day, and specimen results were available within 24 hours of specimen submission. Comprehensive viral tube cultures were performed on specimens that were negative by IA and DFA (seasons 1‐5) or respiratory virus PCR panel (season 6).

Study Definitions

Patients were considered to have CA‐LCI if the first diagnostic specimen positive for influenza was obtained less than 72 hours after hospital admission. Prescriptions for oseltamivir that were consistent with the FDA recommendations were considered to be on‐label prescriptions. Prescriptions for oseltamivir given to patients who did not meet these FDA criteria were considered off‐label prescriptions.5 Patients were considered oseltamivir‐eligible if they were met the criteria for FDA approval for treatment with oseltamivir: at least 1 year of age with influenza symptoms of less than 48 hours duration. Patients who either by age and/or symptom duration were inconsistent with FDA labeling criteria for oseltamivir were deemed oseltamivir‐ineligible. This included those patients for whom influenza test results were received by the clinician more than 48 hours after symptom onset. Patients who were positive for influenza only by viral culture were considered oseltamivir‐ineligible since the time needed to culture influenza virus was >48 hours. Because of the abrupt onset of influenza symptoms, the duration of influenza symptoms was defined by chart review of the emergency room or admission note. A hierarchy of symptoms was used to define the initial onset of influenza‐related symptoms and include the following: (1) For all patients with a history of fever, onset of influenza was defined as the onset of fever as recorded in the first physician note. (2) For patients without a history of fever, the onset of respiratory symptoms was recorded as the onset of influenza. (3) For patients without a history of fever but in whom multiple respiratory symptoms were noted, the onset of symptoms was assigned as the beginning of the increased work of breathing.

Because influenza IA were performed at least 4 times a day during the influenza season, the date of result to clinician was determined to be the same date as specimen collection for patients who had a positive influenza IA. Patients were identified as having a positive influenza result to the clinician 1 day after specimen collection if the test was positive by DFA or PCR. A neurologic adverse event was defined as the occurrence of a seizure after initiation of oseltamivir therapy. A neuropsychiatric adverse event was defined as any significant new neuropsychiatric symptom (psychosis, encephalopathy) recorded after the initiation of oseltamivir therapy. We defined a dermatologic adverse event as the report of any skin findings recorded after the initiation of oseltamivir therapy.

Chronic medical conditions

Information from detailed chart review was used to identify children with Advisory Committee on Immunization Practices (ACIP) high‐risk medical conditions as previously described by our group (asthma, chronic pulmonary disease, cardiac disease, immunosuppression, hemoglobinopathies, chronic renal dysfunction, diabetes mellitus, inborn errors of metabolism, long‐term salicylate therapy, pregnancy, and neurological and neuromuscular disease [NNMD]).6

Electronic Reminder

During season 6, a computer‐based electronic reminder was designed. The reminder stated Consider OSELTAMIVIR if Age >1 year AND symptoms <48 hours. May shorten illness by 36 hours. Page ID approval for more info. The reminder was embedded within the influenza results for all positive determinations, so a clinician would see the reminder when viewing positive laboratory results (Meditech, Westwood, MA).

At the initiation of season 6, we determined prescription rates of oseltamivir in patients with CA‐LCI to measure the baseline rate of oseltamivir prescription. The electronic reminder was initiated during week 11 of influenza activity at our institution and continued through the end of the influenza season.

Data Collection

Two sources of antiviral prescription data were used. Inpatient prescription of antiviral medications was extracted from billing records and chart review; a 10% audit of the medication administration records showed that the billing records correctly identified oseltamivir prescription status in all cases reviewed. Patients with incomplete pharmacy data were removed from the analysis of prescription practices (n = 8). During all seasons studied, the infectious diseases pharmacist (T.A.M.) and an infectious diseases physician (T.E.Z.) reviewed requests for inpatient prescriptions for antiviral medications.

For season 6, daily review of infection control records was performed to conduct surveillance for children hospitalized with CA‐LCI. To determine symptom duration and use of antiviral medications, inpatient medical charts were reviewed at the time of initial identification and then daily thereafter.

Statistical Analysis

Dichotomous variables were created for prescription of oseltamivir, age 1 year and symptom duration of <48 hours at time of clinician receipt of influenza results. Descriptive analyses included calculating the frequencies for categorical variables. Categorical variables were compared using Fisher's exact test. The Cochrane‐Armitage test was employed to test for a trend in the prescription of oseltamivir by season. A 2‐tailed P value of <0.05 was considered significant for all statistical tests. All statistical calculations were performed using standard programs in SAS 9.1 (SAS Institute, Cary, NC), STATA 8.2 (Stata Corp., College Station, TX), and Excel (Microsoft, Redmond, WA).

Prior to the start of season 6, we determined that if the rate of oseltamivir prescription was 40% before initiation of the reminder, we would need 20 eligible patients to detect a difference of 40% or greater in subsequent prescription rates (with 80% power and an alpha of 0.05). Once this enrollment goal was met, an electronic reminder of the eligibility for oseltamivir was initiated.

RESULTS

Use of Antiviral Medications in Children Hospitalized with Influenza, 2000‐2005

From July 2000 to June 2005, 1,058 patients were admitted with laboratory confirmed influenza; 8 were excluded because confirmatory testing was done at an outside institution, 24 were repeat hospitalizations, 89 nosocomial cases, and 8 cases were in patients >21 years. Thus, 929 patients had CA‐LCI and were eligible for inclusion in this study. Most children were infected with influenza A and were 1 year of age (Table 1). During this study period, only 9.3% of study subjects were treated with antiviral medications, most of whom (91%) received oseltamivir. Eight patients received amantadine over all seasons studied.

Characteristics of Patients Hospitalized with CA‐LCI and Oseltamivir Eligibility During Five Influenza Seasons, 2000‐2001 to 2004‐2005
CharacteristicsPatients Hospitalized with CA‐LCI (n = 929)*Eligible to Receive Oseltamivir (n = 305)*
  • Values are number of patients (%).

Age (years)  
<1342 (37)0
1587 (63)305 (100)
Season  
2000‐2001107 (11.5)32 (10)
2001‐2002252 (27)78 (26)
2002‐2003135 (14.5)31 (10)
2003‐2004243 (26)86 (28)
2004‐2005192 (21)78 (26)
Influenza type  
A692 (75) 
B237 (25) 

Overall, one‐third of patients (305/929; 33%) were eligible for treatment with oseltamivir. Among patients 1 year of age, approximately one‐half (305/587; 52%) were oseltamivir‐eligible. The additional 282 patients 1 year were ineligible because test results were returned to the clinician >48 hours after hospital admission. Only 49 (16.1%) of oseltamivir‐eligible patients were prescribed oseltamivir during hospitalization (Figure 1). The rate of prescription of oseltamivir increased over all seasons from 0% in 2000‐2001 to 20% in 2004‐2005. On‐label prescription rates increased from 0% in 2000‐2001 to 37.2% in 2004‐2005 (P < 0.0001; Figure 2).

Figure 1
Study subjects: duration of symptoms, age, and treatment status.
Figure 2
Oseltamivir prescription rates among hospitalized children, 2000‐2005. Percent of eligible or ineligible patients treated with oseltamivir. A significant trend over time of oseltamivir use was found for both eligible and ineligible patients, by nonparametric (NP) trend test (P < 0.0001).

Off‐Label Oseltamivir Prescription

Oseltamivir was prescribed to 29 of the 624 patients who were determined to be oseltamivir‐ineligible. The rate of off‐label use increased over the seasons from 2000 to 2005 from 0% to 8.8% (P < 0.0001; Figure 1). Ineligible patients who received oseltamivir were 1 year of age (n = 11), had test results returned to the clinician 48 hours after hospital admission (n = 18), or both (n = 4). Most off‐label prescriptions occurred in patients who had chronic medical conditions (21/29; 72%), including cardiac disease (n = 9), asthma (n = 6), or prematurity (n = 5). Four of 11 patients 1 year of age who were treated with oseltamivir had influenza‐related respiratory failure. The oseltamivir dose for all patients 1 year of age was 2 mg/kg twice a day, all of whom survived to discharge.

Evaluation of a Computer‐Based Electronic Reminder Designed to Enhance the On‐Label Prescription of Oseltamivir

During season 6, an electronic reminder about the labeled use of oseltamivir was evaluated to determine its ability to increase the rate of prescription of oseltamivir among eligible children hospitalized with CA‐LCI. During season 6, most patients (226/311; 73%) were 1 year of age. A total of 84 patients were determined to be oseltamivir‐eligible (age 1 year and test results back to the clinician within 48 hours of symptom onset).

During the initial 10 weeks of local influenza activity, 20 oseltamivir‐eligible patients were admitted to our institution, and 8 received oseltamivir (40% prescription rate) (Table 2). In addition, 2 of 54 (3.7%) oseltamivir‐ineligible patients were also treated. The computer‐based electronic reminder was initiated in week 11 of the influenza season. After initiation of the reminder, 237 additional children with CA‐LCI were hospitalized, of whom 64 (27%) were determined to be oseltamivir‐eligible. The rate of on‐label prescription of oseltamivir was similar to that observed prior to initiation of the reminder: 16 of 64 patients eligible for antiviral therapy received oseltamivir (25% prescription rate) (Figure 3). An additional 8 patients were prescribed oseltamivir off‐label. The rate of oseltamivir prescription did not change significantly for either oseltamivir‐eligible (40‐25%) or oseltamivir‐ineligible (3.7‐4.6%) (Figure 4).

Figure 3
Proportion of eligible patients who were treated with oseltamivir during the intervention season (2005‐2006). Two proportions represent proportions before and after activation of electronic prompt. No significant difference found in prescription of oseltamivir for those eligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).
Figure 4
Proportion of ineligible patients who were treated with oseltamivir during the intervention season (2005‐2006). Two proportions represent proportions before and after activation of electronic prompt. No significant difference found in prescription of oseltamivir for those ineligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).
Oseltamivir Eligibility and Use Among Patients Hospitalized with CA‐LCI During the Intervention Season, 2005‐2006
Prompt Active?Oseltamivir UseTotal
Yes*No
  • NOTE: No significant difference found in prescription of oseltamivir for those eligible and ineligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).

  • Values are number of patients (%).

  • Values are number of patients.

No   
Eligible8 (40)1220
Ineligible2 (3.7)5254
Yes   
Eligible16 (25)4864
Ineligible8 (4.6)165173
Total34277311

Dermatologic, Neurologic, and Neuropsychiatric Adverse Events

We reviewed the medical records of all patients treated with oseltamivir during the 6 study seasons to identify dermatologic, neurologic, and neuropsychiatric adverse outcomes that developed after the initiation of oseltamivir therapy. No new‐onset seizures, neuropsychiatric, or dermatologic reactions were identified among the children treated with oseltamivir.

DISCUSSION AND CONCLUSION

In this report, we describe the use of oseltamivir over 6 seasons in a cohort of children hospitalized with CA‐LCI at 1 tertiary care pediatric hospital and examine the impact of a mechanism designed to increase prescription among those eligible for oseltamivir. We found that only one‐third of patients hospitalized at our institution were eligible for oseltamivir treatment based on FDA‐approved indications. Of the eligible patients, few were prescribed oseltamivir during their hospitalization. During the sixth season, we employed a computer reminder system for oseltamivir prescription, which had no appreciable effect upon prescription rates. Despite the lack of effect of the electronic reminder system, we observed an increase of on‐label oseltamivir prescriptions over the entire study period. Finally, we identified 11 patients <1 year of age (3%) who were treated with oseltamivir. There were no adverse events identified in this group.

Although previous studies have addressed prescription rates of oseltamivir in children with influenza, few, if any, have looked at how these prescriptions correspond with FDA label criteria. In our cohort, only one‐third of hospitalized children were eligible for treatment with oseltamivir based upon their age and symptom duration at the time the results of rapid laboratory testing became available. Of those patients in our cohort eligible for oseltamivir, few were treated. The prescription of oseltamivir in seasons falls within the ranges found by Schrag et al.7 in their multistate review of pediatric influenza hospitalizations in 2003‐2004. They noted that use of antiviral medications varied by location of surveillance ranging from 3% in Connecticut to 34% in Colorado, indicating significant regional differences in prescription practices.7 Potential causes of low rates of appropriate use of oseltamivir include the observation that many physicians remain unaware of the potential severity of influenza infection in children.8 Additionally, physicians may differ on how to define the onset of influenza infection in children. A recent study published by Ohmit and Monto9 indicated that a fever and cough predicted 83% of children 5 to 12 years old who were determined to be influenza‐positive. Finally, many physicians who do not prescribe antiviral therapy may believe that their patients present too late for appropriate initiation of therapy.10

We identified 29 patients who received oseltamivir although they did not meet the FDA label criteria, of whom 72% had a chronic underlying condition. Moore et al.11 in their surveillance of influenza admissions in Canada found a similar trend. They described 26 of 29 (90%) hospitalized patients receiving antiinfluenza drugs had an underlying disease, and of those without a chronic condition, all had severe influenza‐related complications such as encephalopathy.11

Implementation of a computerized reminder to improve use of oseltamivir had no statistically significant effect on prescribing practice. Our sample size calculation was based on detecting a 40% difference in prescription rates, which limited our power to detect a smaller difference in prescription rates. A systematic review by Garg et al.12 identified barriers to the success of computer‐based decision support systems (CDS), which included failure of practitioners to use the system, poor integration of the system to the physician's workflow, and disagreement with what was recommended. Future enhancements to our inpatient electronic hospital record may allow for more targeted and robust CDS interventions.

We observed an increase in on‐label prescription rates of oseltamivir over the entire study period. We hypothesize that increased use of oseltamivir might be associated with growing concerns of pandemic influenza and attention to fatal influenza in children,13 as evidenced by the recent addition of influenza‐associated deaths in children to the list of nationally notifiable conditions in 2004.14

There has been considerable focus upon potential adverse events associated with treatment with oseltamivir in children. Reports have emerged, primarily from Japan, of neuropsychiatric and dermatologic adverse events of oseltamivir treatment.15 In the fall of 2006, the FDA added a precaution to the labeling of oseltamivir due to these neuropsychiatric events.16 In our treated cohort, no neurologic, neuropsychiatric, or dermatologic adverse events were identified. However, this finding is not surprising given the rarity of these adverse events and the limited number of children treated with oseltamivir in this study.

The strengths of this current study include a large cohort of laboratory‐confirmed influenza in hospitalized children over multiple influenza seasons. In addition, this is the first study of which we are aware that has assessed the number of children eligible for oseltamivir but not treated. The limitations of this study include misclassification bias related to the retrospective study design. Because of this design, onset of influenza symptoms was collected through chart review, and the time of receipt of influenza results from virology was based upon known laboratory turnover time, rather than actual knowledge of time of physician awareness of the result. To address this issue we used a conservative estimate of the time of receipt of influenza test results. In addition, the retrospective design prevented us from assessing the clinical decision‐making process, which led some patients to be treated with oseltamivir and others not. Our evaluation of the electronic reminder was designed to show a large change in prescription practices (ie, 40%), so it had insufficient power to detect a smaller impact. Finally, ascertainment bias may have limited our ability to identify adverse effects.

This study demonstrates that oseltamivir is prescribed infrequently among hospitalized children. Future studies are needed to determine whether appropriate use of oseltamivir improves outcomes among hospitalized children. Additional study of the safety and efficacy of oseltamivir in children aged <1 year is also needed given the large burden of disease in this age group.

Acknowledgements

We thank Michelle Precourt for her assistance with the computer‐based prompt. We also thank Drs. Anna Wheeler Rosenquist and Melissa Donovan for the original data collection for this project. This project was supported in part by the Centers for Disease Control and Prevention, grant H23/CCH32253‐02.

Influenza is a common cause of acute respiratory illness in children, resulting in hospitalization of both healthy and chronically ill children due to influenza‐related complications.1, 2 Currently, amantadine, rimantadine, oseltamivir, and zanamivir are approved for use in children to treat influenza. In early 2006, more than 90% of influenza isolates tested in the US were found to be resistant to the adamantanes, suggesting that these medications might be of limited benefit during future influenza seasons.3 To date, most isolates of influenza remain susceptible to neuraminidase inhibitors, zanamivir and oseltamivir. Zanamivir has not been used extensively in pediatrics because it is delivered by aerosolization, and is only approved by the US Food and Drug Administration (FDA) for children 7 years of age. Oseltamivir is administered orally and is FDA‐approved for use in children 1 year of age within 48 hours of onset of symptoms of influenza virus infection.

Studies performed in outpatient settings have shown that oseltamivir can lessen the severity and reduce the length of influenza illness by 36 hours when therapy is initiated within 2 days of the onset of symptoms.4 Treatment also reduced the frequency of new diagnoses of otitis media and decreased physician‐prescribed antibiotics.4

To date, there are limited data evaluating the use of oseltamivir in either adult or pediatric patients hospitalized with influenza. We sought to describe the use of antiviral medications among children hospitalized with community‐acquired laboratory‐confirmed influenza (CA‐LCI) and to evaluate the effect of a computer‐based electronic reminder to increase the rate of on‐label use of oseltamivir among hospitalized children.

PATIENTS AND METHODS

We performed a retrospective cohort study of patients 21 years of age who were hospitalized with CA‐LCI during 5 consecutive seasons from July 2000 through June 2005 (seasons 1‐5) at the Children's Hospital of Philadelphia (CHOP). CHOP is a 418‐bed tertiary care hospital with about 24,000 hospital admissions each year. Viral diagnostic studies are performed routinely on children hospitalized with acute respiratory symptoms of unknown etiology, which aids in assigning patients to cohorts. Patients who had laboratory confirmation of influenza performed at an outside institution were excluded from this analysis.

From June 2005 through May 2006 (season 6), an observational trial of an electronic clinical decision reminder was performed to assess a mechanism to increase the proportion of eligible children treated with oseltamivir. Patients were included in this analysis if they were 21 years of age and had a diagnostic specimen for influenza obtained less than 72 hours after admission. The CHOP Institutional Review Board approved this study with a waiver of informed consent.

Viral Diagnostic Testing

During the winter months from seasons 1‐5, nasopharyngeal aspirate specimens were initially tested using immunochromatographic membrane assays (IA) for respiratory syncytial virus (RSV) (NOW RSV; Binax, Inc., Scarborough, ME) and, if negative, for influenza virus types A and B (NOW Flu A, NOW Flu B; Binax). If negative, specimens were tested by direct fluorescent antibody (DFA) testing for multiple respiratory viruses, including influenza A and B. During the winter season, IA testing was performed multiple times each day, and DFA was performed once or twice daily with an 8 to 24 hour turnaround time after a specimen was obtained. For season 6, the testing algorithm was revised: a panel of real‐time polymerase chain reaction (PCR) assays were performed to detect nucleic acids from multiple respiratory viruses, including influenza virus types A and B, on specimens that tested negative for influenza and RSV by IA. PCR testing was performed multiple times each day, and specimen results were available within 24 hours of specimen submission. Comprehensive viral tube cultures were performed on specimens that were negative by IA and DFA (seasons 1‐5) or respiratory virus PCR panel (season 6).

Study Definitions

Patients were considered to have CA‐LCI if the first diagnostic specimen positive for influenza was obtained less than 72 hours after hospital admission. Prescriptions for oseltamivir that were consistent with the FDA recommendations were considered to be on‐label prescriptions. Prescriptions for oseltamivir given to patients who did not meet these FDA criteria were considered off‐label prescriptions.5 Patients were considered oseltamivir‐eligible if they were met the criteria for FDA approval for treatment with oseltamivir: at least 1 year of age with influenza symptoms of less than 48 hours duration. Patients who either by age and/or symptom duration were inconsistent with FDA labeling criteria for oseltamivir were deemed oseltamivir‐ineligible. This included those patients for whom influenza test results were received by the clinician more than 48 hours after symptom onset. Patients who were positive for influenza only by viral culture were considered oseltamivir‐ineligible since the time needed to culture influenza virus was >48 hours. Because of the abrupt onset of influenza symptoms, the duration of influenza symptoms was defined by chart review of the emergency room or admission note. A hierarchy of symptoms was used to define the initial onset of influenza‐related symptoms and include the following: (1) For all patients with a history of fever, onset of influenza was defined as the onset of fever as recorded in the first physician note. (2) For patients without a history of fever, the onset of respiratory symptoms was recorded as the onset of influenza. (3) For patients without a history of fever but in whom multiple respiratory symptoms were noted, the onset of symptoms was assigned as the beginning of the increased work of breathing.

Because influenza IA were performed at least 4 times a day during the influenza season, the date of result to clinician was determined to be the same date as specimen collection for patients who had a positive influenza IA. Patients were identified as having a positive influenza result to the clinician 1 day after specimen collection if the test was positive by DFA or PCR. A neurologic adverse event was defined as the occurrence of a seizure after initiation of oseltamivir therapy. A neuropsychiatric adverse event was defined as any significant new neuropsychiatric symptom (psychosis, encephalopathy) recorded after the initiation of oseltamivir therapy. We defined a dermatologic adverse event as the report of any skin findings recorded after the initiation of oseltamivir therapy.

Chronic medical conditions

Information from detailed chart review was used to identify children with Advisory Committee on Immunization Practices (ACIP) high‐risk medical conditions as previously described by our group (asthma, chronic pulmonary disease, cardiac disease, immunosuppression, hemoglobinopathies, chronic renal dysfunction, diabetes mellitus, inborn errors of metabolism, long‐term salicylate therapy, pregnancy, and neurological and neuromuscular disease [NNMD]).6

Electronic Reminder

During season 6, a computer‐based electronic reminder was designed. The reminder stated Consider OSELTAMIVIR if Age >1 year AND symptoms <48 hours. May shorten illness by 36 hours. Page ID approval for more info. The reminder was embedded within the influenza results for all positive determinations, so a clinician would see the reminder when viewing positive laboratory results (Meditech, Westwood, MA).

At the initiation of season 6, we determined prescription rates of oseltamivir in patients with CA‐LCI to measure the baseline rate of oseltamivir prescription. The electronic reminder was initiated during week 11 of influenza activity at our institution and continued through the end of the influenza season.

Data Collection

Two sources of antiviral prescription data were used. Inpatient prescription of antiviral medications was extracted from billing records and chart review; a 10% audit of the medication administration records showed that the billing records correctly identified oseltamivir prescription status in all cases reviewed. Patients with incomplete pharmacy data were removed from the analysis of prescription practices (n = 8). During all seasons studied, the infectious diseases pharmacist (T.A.M.) and an infectious diseases physician (T.E.Z.) reviewed requests for inpatient prescriptions for antiviral medications.

For season 6, daily review of infection control records was performed to conduct surveillance for children hospitalized with CA‐LCI. To determine symptom duration and use of antiviral medications, inpatient medical charts were reviewed at the time of initial identification and then daily thereafter.

Statistical Analysis

Dichotomous variables were created for prescription of oseltamivir, age 1 year and symptom duration of <48 hours at time of clinician receipt of influenza results. Descriptive analyses included calculating the frequencies for categorical variables. Categorical variables were compared using Fisher's exact test. The Cochrane‐Armitage test was employed to test for a trend in the prescription of oseltamivir by season. A 2‐tailed P value of <0.05 was considered significant for all statistical tests. All statistical calculations were performed using standard programs in SAS 9.1 (SAS Institute, Cary, NC), STATA 8.2 (Stata Corp., College Station, TX), and Excel (Microsoft, Redmond, WA).

Prior to the start of season 6, we determined that if the rate of oseltamivir prescription was 40% before initiation of the reminder, we would need 20 eligible patients to detect a difference of 40% or greater in subsequent prescription rates (with 80% power and an alpha of 0.05). Once this enrollment goal was met, an electronic reminder of the eligibility for oseltamivir was initiated.

RESULTS

Use of Antiviral Medications in Children Hospitalized with Influenza, 2000‐2005

From July 2000 to June 2005, 1,058 patients were admitted with laboratory confirmed influenza; 8 were excluded because confirmatory testing was done at an outside institution, 24 were repeat hospitalizations, 89 nosocomial cases, and 8 cases were in patients >21 years. Thus, 929 patients had CA‐LCI and were eligible for inclusion in this study. Most children were infected with influenza A and were 1 year of age (Table 1). During this study period, only 9.3% of study subjects were treated with antiviral medications, most of whom (91%) received oseltamivir. Eight patients received amantadine over all seasons studied.

Characteristics of Patients Hospitalized with CA‐LCI and Oseltamivir Eligibility During Five Influenza Seasons, 2000‐2001 to 2004‐2005
CharacteristicsPatients Hospitalized with CA‐LCI (n = 929)*Eligible to Receive Oseltamivir (n = 305)*
  • Values are number of patients (%).

Age (years)  
<1342 (37)0
1587 (63)305 (100)
Season  
2000‐2001107 (11.5)32 (10)
2001‐2002252 (27)78 (26)
2002‐2003135 (14.5)31 (10)
2003‐2004243 (26)86 (28)
2004‐2005192 (21)78 (26)
Influenza type  
A692 (75) 
B237 (25) 

Overall, one‐third of patients (305/929; 33%) were eligible for treatment with oseltamivir. Among patients 1 year of age, approximately one‐half (305/587; 52%) were oseltamivir‐eligible. The additional 282 patients 1 year were ineligible because test results were returned to the clinician >48 hours after hospital admission. Only 49 (16.1%) of oseltamivir‐eligible patients were prescribed oseltamivir during hospitalization (Figure 1). The rate of prescription of oseltamivir increased over all seasons from 0% in 2000‐2001 to 20% in 2004‐2005. On‐label prescription rates increased from 0% in 2000‐2001 to 37.2% in 2004‐2005 (P < 0.0001; Figure 2).

Figure 1
Study subjects: duration of symptoms, age, and treatment status.
Figure 2
Oseltamivir prescription rates among hospitalized children, 2000‐2005. Percent of eligible or ineligible patients treated with oseltamivir. A significant trend over time of oseltamivir use was found for both eligible and ineligible patients, by nonparametric (NP) trend test (P < 0.0001).

Off‐Label Oseltamivir Prescription

Oseltamivir was prescribed to 29 of the 624 patients who were determined to be oseltamivir‐ineligible. The rate of off‐label use increased over the seasons from 2000 to 2005 from 0% to 8.8% (P < 0.0001; Figure 1). Ineligible patients who received oseltamivir were 1 year of age (n = 11), had test results returned to the clinician 48 hours after hospital admission (n = 18), or both (n = 4). Most off‐label prescriptions occurred in patients who had chronic medical conditions (21/29; 72%), including cardiac disease (n = 9), asthma (n = 6), or prematurity (n = 5). Four of 11 patients 1 year of age who were treated with oseltamivir had influenza‐related respiratory failure. The oseltamivir dose for all patients 1 year of age was 2 mg/kg twice a day, all of whom survived to discharge.

Evaluation of a Computer‐Based Electronic Reminder Designed to Enhance the On‐Label Prescription of Oseltamivir

During season 6, an electronic reminder about the labeled use of oseltamivir was evaluated to determine its ability to increase the rate of prescription of oseltamivir among eligible children hospitalized with CA‐LCI. During season 6, most patients (226/311; 73%) were 1 year of age. A total of 84 patients were determined to be oseltamivir‐eligible (age 1 year and test results back to the clinician within 48 hours of symptom onset).

During the initial 10 weeks of local influenza activity, 20 oseltamivir‐eligible patients were admitted to our institution, and 8 received oseltamivir (40% prescription rate) (Table 2). In addition, 2 of 54 (3.7%) oseltamivir‐ineligible patients were also treated. The computer‐based electronic reminder was initiated in week 11 of the influenza season. After initiation of the reminder, 237 additional children with CA‐LCI were hospitalized, of whom 64 (27%) were determined to be oseltamivir‐eligible. The rate of on‐label prescription of oseltamivir was similar to that observed prior to initiation of the reminder: 16 of 64 patients eligible for antiviral therapy received oseltamivir (25% prescription rate) (Figure 3). An additional 8 patients were prescribed oseltamivir off‐label. The rate of oseltamivir prescription did not change significantly for either oseltamivir‐eligible (40‐25%) or oseltamivir‐ineligible (3.7‐4.6%) (Figure 4).

Figure 3
Proportion of eligible patients who were treated with oseltamivir during the intervention season (2005‐2006). Two proportions represent proportions before and after activation of electronic prompt. No significant difference found in prescription of oseltamivir for those eligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).
Figure 4
Proportion of ineligible patients who were treated with oseltamivir during the intervention season (2005‐2006). Two proportions represent proportions before and after activation of electronic prompt. No significant difference found in prescription of oseltamivir for those ineligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).
Oseltamivir Eligibility and Use Among Patients Hospitalized with CA‐LCI During the Intervention Season, 2005‐2006
Prompt Active?Oseltamivir UseTotal
Yes*No
  • NOTE: No significant difference found in prescription of oseltamivir for those eligible and ineligible before and after the prompt was active, by Fisher's exact tests (P > 0.5).

  • Values are number of patients (%).

  • Values are number of patients.

No   
Eligible8 (40)1220
Ineligible2 (3.7)5254
Yes   
Eligible16 (25)4864
Ineligible8 (4.6)165173
Total34277311

Dermatologic, Neurologic, and Neuropsychiatric Adverse Events

We reviewed the medical records of all patients treated with oseltamivir during the 6 study seasons to identify dermatologic, neurologic, and neuropsychiatric adverse outcomes that developed after the initiation of oseltamivir therapy. No new‐onset seizures, neuropsychiatric, or dermatologic reactions were identified among the children treated with oseltamivir.

DISCUSSION AND CONCLUSION

In this report, we describe the use of oseltamivir over 6 seasons in a cohort of children hospitalized with CA‐LCI at 1 tertiary care pediatric hospital and examine the impact of a mechanism designed to increase prescription among those eligible for oseltamivir. We found that only one‐third of patients hospitalized at our institution were eligible for oseltamivir treatment based on FDA‐approved indications. Of the eligible patients, few were prescribed oseltamivir during their hospitalization. During the sixth season, we employed a computer reminder system for oseltamivir prescription, which had no appreciable effect upon prescription rates. Despite the lack of effect of the electronic reminder system, we observed an increase of on‐label oseltamivir prescriptions over the entire study period. Finally, we identified 11 patients <1 year of age (3%) who were treated with oseltamivir. There were no adverse events identified in this group.

Although previous studies have addressed prescription rates of oseltamivir in children with influenza, few, if any, have looked at how these prescriptions correspond with FDA label criteria. In our cohort, only one‐third of hospitalized children were eligible for treatment with oseltamivir based upon their age and symptom duration at the time the results of rapid laboratory testing became available. Of those patients in our cohort eligible for oseltamivir, few were treated. The prescription of oseltamivir in seasons falls within the ranges found by Schrag et al.7 in their multistate review of pediatric influenza hospitalizations in 2003‐2004. They noted that use of antiviral medications varied by location of surveillance ranging from 3% in Connecticut to 34% in Colorado, indicating significant regional differences in prescription practices.7 Potential causes of low rates of appropriate use of oseltamivir include the observation that many physicians remain unaware of the potential severity of influenza infection in children.8 Additionally, physicians may differ on how to define the onset of influenza infection in children. A recent study published by Ohmit and Monto9 indicated that a fever and cough predicted 83% of children 5 to 12 years old who were determined to be influenza‐positive. Finally, many physicians who do not prescribe antiviral therapy may believe that their patients present too late for appropriate initiation of therapy.10

We identified 29 patients who received oseltamivir although they did not meet the FDA label criteria, of whom 72% had a chronic underlying condition. Moore et al.11 in their surveillance of influenza admissions in Canada found a similar trend. They described 26 of 29 (90%) hospitalized patients receiving antiinfluenza drugs had an underlying disease, and of those without a chronic condition, all had severe influenza‐related complications such as encephalopathy.11

Implementation of a computerized reminder to improve use of oseltamivir had no statistically significant effect on prescribing practice. Our sample size calculation was based on detecting a 40% difference in prescription rates, which limited our power to detect a smaller difference in prescription rates. A systematic review by Garg et al.12 identified barriers to the success of computer‐based decision support systems (CDS), which included failure of practitioners to use the system, poor integration of the system to the physician's workflow, and disagreement with what was recommended. Future enhancements to our inpatient electronic hospital record may allow for more targeted and robust CDS interventions.

We observed an increase in on‐label prescription rates of oseltamivir over the entire study period. We hypothesize that increased use of oseltamivir might be associated with growing concerns of pandemic influenza and attention to fatal influenza in children,13 as evidenced by the recent addition of influenza‐associated deaths in children to the list of nationally notifiable conditions in 2004.14

There has been considerable focus upon potential adverse events associated with treatment with oseltamivir in children. Reports have emerged, primarily from Japan, of neuropsychiatric and dermatologic adverse events of oseltamivir treatment.15 In the fall of 2006, the FDA added a precaution to the labeling of oseltamivir due to these neuropsychiatric events.16 In our treated cohort, no neurologic, neuropsychiatric, or dermatologic adverse events were identified. However, this finding is not surprising given the rarity of these adverse events and the limited number of children treated with oseltamivir in this study.

The strengths of this current study include a large cohort of laboratory‐confirmed influenza in hospitalized children over multiple influenza seasons. In addition, this is the first study of which we are aware that has assessed the number of children eligible for oseltamivir but not treated. The limitations of this study include misclassification bias related to the retrospective study design. Because of this design, onset of influenza symptoms was collected through chart review, and the time of receipt of influenza results from virology was based upon known laboratory turnover time, rather than actual knowledge of time of physician awareness of the result. To address this issue we used a conservative estimate of the time of receipt of influenza test results. In addition, the retrospective design prevented us from assessing the clinical decision‐making process, which led some patients to be treated with oseltamivir and others not. Our evaluation of the electronic reminder was designed to show a large change in prescription practices (ie, 40%), so it had insufficient power to detect a smaller impact. Finally, ascertainment bias may have limited our ability to identify adverse effects.

This study demonstrates that oseltamivir is prescribed infrequently among hospitalized children. Future studies are needed to determine whether appropriate use of oseltamivir improves outcomes among hospitalized children. Additional study of the safety and efficacy of oseltamivir in children aged <1 year is also needed given the large burden of disease in this age group.

Acknowledgements

We thank Michelle Precourt for her assistance with the computer‐based prompt. We also thank Drs. Anna Wheeler Rosenquist and Melissa Donovan for the original data collection for this project. This project was supported in part by the Centers for Disease Control and Prevention, grant H23/CCH32253‐02.

References
  1. Izurieta HS,Thompson WW,Kramarz P, et al.Influenza and the rates of hospitalization for respiratory disease among infants and young children.N Engl J Med.2000;342:232239.
  2. Neuzil KM,Mellen BG,Wright PF,Mitchel EF,Griffin MR.The effect of influenza on hospitalizations, outpatient visits and courses of antibiotics in children.N Engl J Med.2000;342:225231.
  3. Centers for Disease Control and Prevention (CDC). Diseases and Conditions. Seasonal Flu. CDC Health Alert: CDC recommends against the use of amantadine and rimantadine for the treatment or prophylaxis of influenza in the United States during the 2005–06 influenza season. January 14, 2006. Available at http://www.cdc.gov/flu/han011406.htm. Accessed November2008.
  4. Whitley RJ,Hayden FG,Reisinger KS, et al.Oral oseltamivir treatment of influenza in children.Pediatr Infect Dis J.2001;20(2):127133.
  5. Shah S,Hall M,Goodman DM, et al.Off‐label drug use in hospitalized children.Arch Pediatr Adolesc Med.2007;161(3):282290.
  6. Keren R,Zaoutis TE,Bridges CB, et al.Neurological and neuromuscular disease as a risk factor for respiratory failure in children hospitalized with influenza infection.JAMA.2005;294:21882194.
  7. Schrag SJ,Shay DK,Gershman K, et al.Multistate surveillance for laboratory‐confirmed influenza‐associated hospitalizations in children 2003–2004.Pediatr Infect Dis J.2006;25(5):395400.
  8. Dominguez SR,Daum RS.Physician knowledge and perspectives regarding influenza and influenza vaccination.Hum Vaccin.2005;1(2):7479.
  9. Ohmit SE,Monto AS.Symptomatic predictors of influenza virus positivity in children during the influenza season.Clin Infect Dis.2006;43:564568.
  10. Rothberg MB,Bonner AB,Rajab MH,Kim HS,Stechenberg BW,Rose DN.Effects of local variation, specialty, and beliefs on antiviral prescribing for influenza.Clin Infect Dis.2006;42:9599.
  11. Moore DL,Vaudry W,Scheifele DW, et al.Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003–2004.Pediatrics.2006;118:e610e619.
  12. Garg AX,Adhikari NK,McDonald H, et al.Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review.JAMA.2005;293:12231238.
  13. Bhat N,Wright JG,Broder KR, et al.Influenza‐associated deaths among children in the United States, 2003–2004.N Engl J Med.2005;353(24):25592567.
  14. Centers for Disease Control and Prevention (CDC). Diseases and Conditions. Seasonal Flu. Flu Activity 25(6):572.
  15. Edwards ET,Truffa MM,Mosholder AD.Post‐Marketing Adverse Event Reports. Review of Central Nervous System/Psychiatric Disorders Associated with the Use of Tamiflu, Drug: Oseltamivir Phosphate. Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology.2006. OSE PID #D060393 Oseltamivir—Neuropsychiatric Events.
References
  1. Izurieta HS,Thompson WW,Kramarz P, et al.Influenza and the rates of hospitalization for respiratory disease among infants and young children.N Engl J Med.2000;342:232239.
  2. Neuzil KM,Mellen BG,Wright PF,Mitchel EF,Griffin MR.The effect of influenza on hospitalizations, outpatient visits and courses of antibiotics in children.N Engl J Med.2000;342:225231.
  3. Centers for Disease Control and Prevention (CDC). Diseases and Conditions. Seasonal Flu. CDC Health Alert: CDC recommends against the use of amantadine and rimantadine for the treatment or prophylaxis of influenza in the United States during the 2005–06 influenza season. January 14, 2006. Available at http://www.cdc.gov/flu/han011406.htm. Accessed November2008.
  4. Whitley RJ,Hayden FG,Reisinger KS, et al.Oral oseltamivir treatment of influenza in children.Pediatr Infect Dis J.2001;20(2):127133.
  5. Shah S,Hall M,Goodman DM, et al.Off‐label drug use in hospitalized children.Arch Pediatr Adolesc Med.2007;161(3):282290.
  6. Keren R,Zaoutis TE,Bridges CB, et al.Neurological and neuromuscular disease as a risk factor for respiratory failure in children hospitalized with influenza infection.JAMA.2005;294:21882194.
  7. Schrag SJ,Shay DK,Gershman K, et al.Multistate surveillance for laboratory‐confirmed influenza‐associated hospitalizations in children 2003–2004.Pediatr Infect Dis J.2006;25(5):395400.
  8. Dominguez SR,Daum RS.Physician knowledge and perspectives regarding influenza and influenza vaccination.Hum Vaccin.2005;1(2):7479.
  9. Ohmit SE,Monto AS.Symptomatic predictors of influenza virus positivity in children during the influenza season.Clin Infect Dis.2006;43:564568.
  10. Rothberg MB,Bonner AB,Rajab MH,Kim HS,Stechenberg BW,Rose DN.Effects of local variation, specialty, and beliefs on antiviral prescribing for influenza.Clin Infect Dis.2006;42:9599.
  11. Moore DL,Vaudry W,Scheifele DW, et al.Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003–2004.Pediatrics.2006;118:e610e619.
  12. Garg AX,Adhikari NK,McDonald H, et al.Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review.JAMA.2005;293:12231238.
  13. Bhat N,Wright JG,Broder KR, et al.Influenza‐associated deaths among children in the United States, 2003–2004.N Engl J Med.2005;353(24):25592567.
  14. Centers for Disease Control and Prevention (CDC). Diseases and Conditions. Seasonal Flu. Flu Activity 25(6):572.
  15. Edwards ET,Truffa MM,Mosholder AD.Post‐Marketing Adverse Event Reports. Review of Central Nervous System/Psychiatric Disorders Associated with the Use of Tamiflu, Drug: Oseltamivir Phosphate. Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology.2006. OSE PID #D060393 Oseltamivir—Neuropsychiatric Events.
Issue
Journal of Hospital Medicine - 4(3)
Issue
Journal of Hospital Medicine - 4(3)
Page Number
171-178
Page Number
171-178
Article Type
Display Headline
Treatment with oseltamivir in children hospitalized with community‐acquired, laboratory‐confirmed influenza: Review of five seasons and evaluation of an electronic reminder
Display Headline
Treatment with oseltamivir in children hospitalized with community‐acquired, laboratory‐confirmed influenza: Review of five seasons and evaluation of an electronic reminder
Legacy Keywords
children, influenza, oseltamivir
Legacy Keywords
children, influenza, oseltamivir
Sections
Article Source

Copyright © 2009 Society of Hospital Medicine

Disallow All Ads
Correspondence Location
Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Main Building 9S52, Philadelphia, PA 19104
Content Gating
No Gating (article Unlocked/Free)
Alternative CME
Article PDF Media