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Opioids often prescribed in low-income areas
Also today, undervaccination poses a particular danger to patients with HIV, patients with inflammatory bowl disease aren’t getting appropriate reproductive counseling, and the type of exercise does matter when it comes to preventing falls among elderly patients.
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Apple Podcasts
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Also today, undervaccination poses a particular danger to patients with HIV, patients with inflammatory bowl disease aren’t getting appropriate reproductive counseling, and the type of exercise does matter when it comes to preventing falls among elderly patients.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, undervaccination poses a particular danger to patients with HIV, patients with inflammatory bowl disease aren’t getting appropriate reproductive counseling, and the type of exercise does matter when it comes to preventing falls among elderly patients.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Suicide: Igor Galynker
One major topic of conversation centers around suicide-specific diagnosis. And later, Renee Kohanski, MD, talks about the importance of communication. You can listen to Dr. Galynker’s first appearance on the Psychcast here.
One major topic of conversation centers around suicide-specific diagnosis. And later, Renee Kohanski, MD, talks about the importance of communication. You can listen to Dr. Galynker’s first appearance on the Psychcast here.
One major topic of conversation centers around suicide-specific diagnosis. And later, Renee Kohanski, MD, talks about the importance of communication. You can listen to Dr. Galynker’s first appearance on the Psychcast here.
Conservatism spreads in prostate cancer
, the United States now has more than 100 measles cases for the year, e-cigarette use reverses progress in reducing teens’ tobacco use, and consider adopting the MESA 10-year coronary heart disease risk calculator.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
, the United States now has more than 100 measles cases for the year, e-cigarette use reverses progress in reducing teens’ tobacco use, and consider adopting the MESA 10-year coronary heart disease risk calculator.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
, the United States now has more than 100 measles cases for the year, e-cigarette use reverses progress in reducing teens’ tobacco use, and consider adopting the MESA 10-year coronary heart disease risk calculator.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Pregnant women want genome guidance
Also today, a look at asthma, obesity, and the risk for severe sleep apnea in children, new questions about the role that antinuclear antibodies are playing in systemic lupus erythematosus, and the lifetime cost of tobacco is nearly $2 million per smoker.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, a look at asthma, obesity, and the risk for severe sleep apnea in children, new questions about the role that antinuclear antibodies are playing in systemic lupus erythematosus, and the lifetime cost of tobacco is nearly $2 million per smoker.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, a look at asthma, obesity, and the risk for severe sleep apnea in children, new questions about the role that antinuclear antibodies are playing in systemic lupus erythematosus, and the lifetime cost of tobacco is nearly $2 million per smoker.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
SGLT2s for heart failure first, diabetes second
Also today, influenza activity hits a seasonal high, the U.S. Supreme Court halts a Louisiana abortion law from taking effect, and cilostazol plus aspirin or clopidogrel reduces the risk of recurrent stroke.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, influenza activity hits a seasonal high, the U.S. Supreme Court halts a Louisiana abortion law from taking effect, and cilostazol plus aspirin or clopidogrel reduces the risk of recurrent stroke.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, influenza activity hits a seasonal high, the U.S. Supreme Court halts a Louisiana abortion law from taking effect, and cilostazol plus aspirin or clopidogrel reduces the risk of recurrent stroke.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
500 Women in Medicine: Part I
Ms. Gerull and Ms. Loe are third-year medical students at Washington University School of Medicine in St. Louis.
Their aim is to create a network of support and advancement for women in medicine. 500 Women in Medicine is a pod of the organization 500 Women Scientists.
In this episode, Nick Andrews speaks with the two innovators about their motivation to found this organization.
Correction, 3/12/19: An earlier version of this article misstated Kate Gerull's name.
Ms. Gerull and Ms. Loe are third-year medical students at Washington University School of Medicine in St. Louis.
Their aim is to create a network of support and advancement for women in medicine. 500 Women in Medicine is a pod of the organization 500 Women Scientists.
In this episode, Nick Andrews speaks with the two innovators about their motivation to found this organization.
Correction, 3/12/19: An earlier version of this article misstated Kate Gerull's name.
Ms. Gerull and Ms. Loe are third-year medical students at Washington University School of Medicine in St. Louis.
Their aim is to create a network of support and advancement for women in medicine. 500 Women in Medicine is a pod of the organization 500 Women Scientists.
In this episode, Nick Andrews speaks with the two innovators about their motivation to found this organization.
Correction, 3/12/19: An earlier version of this article misstated Kate Gerull's name.
Novel plasma biomarkers for Alzheimer’s
Also today, biomarkers predict VTE risk with menopausal oral hormone therapy, there is a cloud of inconsistency hanging over cannabis data, and compounded pain creams are no better than placebo for chronic localized pain.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, biomarkers predict VTE risk with menopausal oral hormone therapy, there is a cloud of inconsistency hanging over cannabis data, and compounded pain creams are no better than placebo for chronic localized pain.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, biomarkers predict VTE risk with menopausal oral hormone therapy, there is a cloud of inconsistency hanging over cannabis data, and compounded pain creams are no better than placebo for chronic localized pain.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
‘Simple’ way to cut PAD risk, misguided ED visits for atrial fib, and more
This week in MDedge Cardiocast: Elevated CAC in highly active men doesn’t raise risk of death, Life’s Simple 7 scores can be used to modify PAD risk, medical guidance often leads atrial fibrillation patients to needlessly seek emergency department care, and thinking of pregnancy as a stress test can help predict women’s future cardiovascular risk.
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TuneIn
This week in MDedge Cardiocast: Elevated CAC in highly active men doesn’t raise risk of death, Life’s Simple 7 scores can be used to modify PAD risk, medical guidance often leads atrial fibrillation patients to needlessly seek emergency department care, and thinking of pregnancy as a stress test can help predict women’s future cardiovascular risk.
Amazon AlexaApple Podcasts
Google Podcasts
TuneIn
This week in MDedge Cardiocast: Elevated CAC in highly active men doesn’t raise risk of death, Life’s Simple 7 scores can be used to modify PAD risk, medical guidance often leads atrial fibrillation patients to needlessly seek emergency department care, and thinking of pregnancy as a stress test can help predict women’s future cardiovascular risk.
Amazon AlexaApple Podcasts
Google Podcasts
TuneIn
Biosimilars: Gary H. Lyman
In this episode, Gary H. Lyman, MD (https://bitly.is/2UJzUly) joins David Henry, MD, (http://bit.ly/2MFDfzm) to talk about biosimilars.
Dr. Lyman talks about the definition of biosimilars, how they are made, which are approved, and which ones are on the market.
He also talks about extrapolation and interchangeability as well as where some biosimilars stand in both ASCO and NCCN guidelines for patients who are going into supportive care.
And Ilana Yurkiewicz, MD (https://stanford.io/2RXPixR), talks about what the word "cure" means to you compared to what it means to patients in a world with OS, PFS, DFS, CR, etc. (26:35).
Subscribe here:
Show Notes
By Hitomi Hosoya, MD, PhD
- Biosimilars are biologic products that are highly similar to the reference products with no clinically meaningful difference in terms of safety, efficacy, purity, and potency.
- Unlike “generic” products, biosimilars are produced in living systems, therefore they cannot be replicated identically.
- The Food and Drug Administration encourages companies to produce biosimilars as a patent expires on the original product.
- For approval, the FDA requires largely preclinical data; amino acid sequence and molecular structures, pharmacodynamics and pharmacokinetic data in animal models and humans. Also, no greater immunogenicity should be demonstrated.
- Large randomized trials are not usually required for approval of biosimilars as there is already data on the original product. Post-marketing surveillance is important.
- 14 biosimilars have already been approved by the FDA.
- Interchangeable designation of biosimilars is yet to come.
- At this early stage of biosimilar marketing, we see a 10%-11% cost reduction. This is expected to increase as the market expands.
References:
JAMA Oncol.2018 Feb 1;4(2):241-247
Contact us: [email protected]
MDedge Hematology/Oncology Twitter: @MDedgeHemOnc
Ilana Yurkiewicz Twitter: @ilanayurkiewicz
In this episode, Gary H. Lyman, MD (https://bitly.is/2UJzUly) joins David Henry, MD, (http://bit.ly/2MFDfzm) to talk about biosimilars.
Dr. Lyman talks about the definition of biosimilars, how they are made, which are approved, and which ones are on the market.
He also talks about extrapolation and interchangeability as well as where some biosimilars stand in both ASCO and NCCN guidelines for patients who are going into supportive care.
And Ilana Yurkiewicz, MD (https://stanford.io/2RXPixR), talks about what the word "cure" means to you compared to what it means to patients in a world with OS, PFS, DFS, CR, etc. (26:35).
Subscribe here:
Show Notes
By Hitomi Hosoya, MD, PhD
- Biosimilars are biologic products that are highly similar to the reference products with no clinically meaningful difference in terms of safety, efficacy, purity, and potency.
- Unlike “generic” products, biosimilars are produced in living systems, therefore they cannot be replicated identically.
- The Food and Drug Administration encourages companies to produce biosimilars as a patent expires on the original product.
- For approval, the FDA requires largely preclinical data; amino acid sequence and molecular structures, pharmacodynamics and pharmacokinetic data in animal models and humans. Also, no greater immunogenicity should be demonstrated.
- Large randomized trials are not usually required for approval of biosimilars as there is already data on the original product. Post-marketing surveillance is important.
- 14 biosimilars have already been approved by the FDA.
- Interchangeable designation of biosimilars is yet to come.
- At this early stage of biosimilar marketing, we see a 10%-11% cost reduction. This is expected to increase as the market expands.
References:
JAMA Oncol.2018 Feb 1;4(2):241-247
Contact us: [email protected]
MDedge Hematology/Oncology Twitter: @MDedgeHemOnc
Ilana Yurkiewicz Twitter: @ilanayurkiewicz
In this episode, Gary H. Lyman, MD (https://bitly.is/2UJzUly) joins David Henry, MD, (http://bit.ly/2MFDfzm) to talk about biosimilars.
Dr. Lyman talks about the definition of biosimilars, how they are made, which are approved, and which ones are on the market.
He also talks about extrapolation and interchangeability as well as where some biosimilars stand in both ASCO and NCCN guidelines for patients who are going into supportive care.
And Ilana Yurkiewicz, MD (https://stanford.io/2RXPixR), talks about what the word "cure" means to you compared to what it means to patients in a world with OS, PFS, DFS, CR, etc. (26:35).
Subscribe here:
Show Notes
By Hitomi Hosoya, MD, PhD
- Biosimilars are biologic products that are highly similar to the reference products with no clinically meaningful difference in terms of safety, efficacy, purity, and potency.
- Unlike “generic” products, biosimilars are produced in living systems, therefore they cannot be replicated identically.
- The Food and Drug Administration encourages companies to produce biosimilars as a patent expires on the original product.
- For approval, the FDA requires largely preclinical data; amino acid sequence and molecular structures, pharmacodynamics and pharmacokinetic data in animal models and humans. Also, no greater immunogenicity should be demonstrated.
- Large randomized trials are not usually required for approval of biosimilars as there is already data on the original product. Post-marketing surveillance is important.
- 14 biosimilars have already been approved by the FDA.
- Interchangeable designation of biosimilars is yet to come.
- At this early stage of biosimilar marketing, we see a 10%-11% cost reduction. This is expected to increase as the market expands.
References:
JAMA Oncol.2018 Feb 1;4(2):241-247
Contact us: [email protected]
MDedge Hematology/Oncology Twitter: @MDedgeHemOnc
Ilana Yurkiewicz Twitter: @ilanayurkiewicz
Rise in HCV linked to OxyContin reformulation
Also today, public health experts have attributed to the opioid epidemic the recent alarming rise in the rate of hepatitis C virus infection. medical advice prompts unneeded emergency visits by patients with atrial fibrillation, and legal marijuana may complicate substance use disorder treatment in adolescents.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, public health experts have attributed to the opioid epidemic the recent alarming rise in the rate of hepatitis C virus infection. medical advice prompts unneeded emergency visits by patients with atrial fibrillation, and legal marijuana may complicate substance use disorder treatment in adolescents.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
Also today, public health experts have attributed to the opioid epidemic the recent alarming rise in the rate of hepatitis C virus infection. medical advice prompts unneeded emergency visits by patients with atrial fibrillation, and legal marijuana may complicate substance use disorder treatment in adolescents.
Amazon Alexa
Apple Podcasts
Google Podcasts
Spotify
