Are early exposures linked with childhood peanut allergy?

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Peanut allergies are associated with intake of soy products in the first 2 years of life, a history of rashes over joints and skin creases (especially oozing, crusted ones), and use of skin creams containing peanut oil. Instructing parents to avoid peanut oil–containing creams and limiting soy milk or formula in the first 2 years of life may reduce sensitization.

 
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Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348:977–985.

Kelly Hayday, MD
Scott Shannon, MD
Department of Family and Community Medicine, University of Missouri–Columbia.

[email protected].

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Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348:977–985.

Kelly Hayday, MD
Scott Shannon, MD
Department of Family and Community Medicine, University of Missouri–Columbia.

[email protected].

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Practice Recommendations from Key Studies

Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348:977–985.

Kelly Hayday, MD
Scott Shannon, MD
Department of Family and Community Medicine, University of Missouri–Columbia.

[email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Peanut allergies are associated with intake of soy products in the first 2 years of life, a history of rashes over joints and skin creases (especially oozing, crusted ones), and use of skin creams containing peanut oil. Instructing parents to avoid peanut oil–containing creams and limiting soy milk or formula in the first 2 years of life may reduce sensitization.

 
PRACTICE RECOMMENDATIONS

Peanut allergies are associated with intake of soy products in the first 2 years of life, a history of rashes over joints and skin creases (especially oozing, crusted ones), and use of skin creams containing peanut oil. Instructing parents to avoid peanut oil–containing creams and limiting soy milk or formula in the first 2 years of life may reduce sensitization.

 
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Low-carbohydrate diet effective for adults

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Low-carbohydrate diet effective for adults
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Very-low-carbohydrate diets result in more weight loss than low-fat/low-calorie diets after 6 months, with no adverse impact on lipids, bone density, or blood pressure. Low-carbohydrate diets should be considered in otherwise healthy obese patients who are interested in this particular strategy for weight loss or who have failed other attempts.

 
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Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrin Metab 2003; 88:1617–1623.

Daniel F. McCarter, MD
Department of Family Medicine, University of Virginia, Stoney Creek Family Practice, Nellysford, Va.

[email protected].

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Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrin Metab 2003; 88:1617–1623.

Daniel F. McCarter, MD
Department of Family Medicine, University of Virginia, Stoney Creek Family Practice, Nellysford, Va.

[email protected].

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Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrin Metab 2003; 88:1617–1623.

Daniel F. McCarter, MD
Department of Family Medicine, University of Virginia, Stoney Creek Family Practice, Nellysford, Va.

[email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Very-low-carbohydrate diets result in more weight loss than low-fat/low-calorie diets after 6 months, with no adverse impact on lipids, bone density, or blood pressure. Low-carbohydrate diets should be considered in otherwise healthy obese patients who are interested in this particular strategy for weight loss or who have failed other attempts.

 
PRACTICE RECOMMENDATIONS

Very-low-carbohydrate diets result in more weight loss than low-fat/low-calorie diets after 6 months, with no adverse impact on lipids, bone density, or blood pressure. Low-carbohydrate diets should be considered in otherwise healthy obese patients who are interested in this particular strategy for weight loss or who have failed other attempts.

 
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Gabapentin helpful for hot flushes in postmenopausal women

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Gabapentin helpful for hot flushes in postmenopausal women
PRACTICE RECOMMENDATIONS

Gabapentin effectively decreases both the frequency and severity of hot flushes in postmenopausal women who report 7 or more hot flushes per day. Gabapentin, an anticonvulsant, is indicated by the US Food and Drug Administration as adjunct therapy in the treatment of partial seizures in epilepsy.

Although somnolence, dizziness, and peripheral edema are commonly experienced by patients taking this medication, gabapentin provides an effective treatment for reducing the number of hot flushes in women for whom hormone replacement therapy (HRT) is not recommended or desired.

 
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Guttuso T, Kurlan R, McDermott MP, Kieburtz K. Gabapentin’s effects on hot flashes in postmenopausal women: A randomized controlled trial. Obstet Gynecol 2003; 101:337–345.

Christopher Haines, MD, MA
Marc I. Harwood, MD
Department of Family Medicine, Thomas Jefferson University Hospital, Philadelphia, Pa.

[email protected].

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Guttuso T, Kurlan R, McDermott MP, Kieburtz K. Gabapentin’s effects on hot flashes in postmenopausal women: A randomized controlled trial. Obstet Gynecol 2003; 101:337–345.

Christopher Haines, MD, MA
Marc I. Harwood, MD
Department of Family Medicine, Thomas Jefferson University Hospital, Philadelphia, Pa.

[email protected].

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Guttuso T, Kurlan R, McDermott MP, Kieburtz K. Gabapentin’s effects on hot flashes in postmenopausal women: A randomized controlled trial. Obstet Gynecol 2003; 101:337–345.

Christopher Haines, MD, MA
Marc I. Harwood, MD
Department of Family Medicine, Thomas Jefferson University Hospital, Philadelphia, Pa.

[email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Gabapentin effectively decreases both the frequency and severity of hot flushes in postmenopausal women who report 7 or more hot flushes per day. Gabapentin, an anticonvulsant, is indicated by the US Food and Drug Administration as adjunct therapy in the treatment of partial seizures in epilepsy.

Although somnolence, dizziness, and peripheral edema are commonly experienced by patients taking this medication, gabapentin provides an effective treatment for reducing the number of hot flushes in women for whom hormone replacement therapy (HRT) is not recommended or desired.

 
PRACTICE RECOMMENDATIONS

Gabapentin effectively decreases both the frequency and severity of hot flushes in postmenopausal women who report 7 or more hot flushes per day. Gabapentin, an anticonvulsant, is indicated by the US Food and Drug Administration as adjunct therapy in the treatment of partial seizures in epilepsy.

Although somnolence, dizziness, and peripheral edema are commonly experienced by patients taking this medication, gabapentin provides an effective treatment for reducing the number of hot flushes in women for whom hormone replacement therapy (HRT) is not recommended or desired.

 
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Gabapentin helpful for hot flushes in postmenopausal women
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Metoclopramide reduces nausea from emergency contraception

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Metoclopramide reduces nausea from emergency contraception
PRACTICE RECOMMENDATIONS

This study provides good evidence that metoclopramide reduces the nausea and cramping associated with emergency contraception. The benefit, however, is small, and the effect of metoclopramide on the effectiveness of the emergency contraceptive is not known.

Clinicians may prescribe 10 mg metoclopramide along with combined estrogen/progestin emergency hormonal contraception. Results are likely to be similar with agents comparable to metoclopramide.

 
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Ragan RE, Rock RW, Buck HW. Metoclopramide pretreatment attenuates emergency contraceptive-associated nausea. Am J Obstet Gynecol 2003; 188:330–333.

David Cunningham, MD
Warren Newton, MD, MPH
Department of Family Medicine, University of North Carolina, Chapel Hill.

[email protected].

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Ragan RE, Rock RW, Buck HW. Metoclopramide pretreatment attenuates emergency contraceptive-associated nausea. Am J Obstet Gynecol 2003; 188:330–333.

David Cunningham, MD
Warren Newton, MD, MPH
Department of Family Medicine, University of North Carolina, Chapel Hill.

[email protected].

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Ragan RE, Rock RW, Buck HW. Metoclopramide pretreatment attenuates emergency contraceptive-associated nausea. Am J Obstet Gynecol 2003; 188:330–333.

David Cunningham, MD
Warren Newton, MD, MPH
Department of Family Medicine, University of North Carolina, Chapel Hill.

[email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

This study provides good evidence that metoclopramide reduces the nausea and cramping associated with emergency contraception. The benefit, however, is small, and the effect of metoclopramide on the effectiveness of the emergency contraceptive is not known.

Clinicians may prescribe 10 mg metoclopramide along with combined estrogen/progestin emergency hormonal contraception. Results are likely to be similar with agents comparable to metoclopramide.

 
PRACTICE RECOMMENDATIONS

This study provides good evidence that metoclopramide reduces the nausea and cramping associated with emergency contraception. The benefit, however, is small, and the effect of metoclopramide on the effectiveness of the emergency contraceptive is not known.

Clinicians may prescribe 10 mg metoclopramide along with combined estrogen/progestin emergency hormonal contraception. Results are likely to be similar with agents comparable to metoclopramide.

 
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Diclofenac more effective than acetaminophen in osteoarthritis of the knee

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Diclofenac more effective than acetaminophen in osteoarthritis of the knee
PRACTICE RECOMMENDATIONS

Diclofenac 150 mg/d is more effective in controlling osteoarthritis symptoms than acetaminophen 4 g/d in patients previously requiring an nonsteroidal anti-inflammatory drug (NSAID).

Since acetaminophen is less expensive and better tolerated, it is reasonable to attempt a 2-week trial in all patients prior to initiating treatment with NSAIDs.

 
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Case JP, Baliumnas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis. A randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003; 163:169–178.

Marc R. Via, MD
Department of Family and Community Medicine, Scott & White Memorial Hospital, Texas A & M University System Health Science Center College of Medicine Temple, Tex.

[email protected].

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Case JP, Baliumnas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis. A randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003; 163:169–178.

Marc R. Via, MD
Department of Family and Community Medicine, Scott & White Memorial Hospital, Texas A & M University System Health Science Center College of Medicine Temple, Tex.

[email protected].

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Case JP, Baliumnas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis. A randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003; 163:169–178.

Marc R. Via, MD
Department of Family and Community Medicine, Scott & White Memorial Hospital, Texas A & M University System Health Science Center College of Medicine Temple, Tex.

[email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Diclofenac 150 mg/d is more effective in controlling osteoarthritis symptoms than acetaminophen 4 g/d in patients previously requiring an nonsteroidal anti-inflammatory drug (NSAID).

Since acetaminophen is less expensive and better tolerated, it is reasonable to attempt a 2-week trial in all patients prior to initiating treatment with NSAIDs.

 
PRACTICE RECOMMENDATIONS

Diclofenac 150 mg/d is more effective in controlling osteoarthritis symptoms than acetaminophen 4 g/d in patients previously requiring an nonsteroidal anti-inflammatory drug (NSAID).

Since acetaminophen is less expensive and better tolerated, it is reasonable to attempt a 2-week trial in all patients prior to initiating treatment with NSAIDs.

 
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Patients with mild scoliosis have good prognosis

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Patients with mild scoliosis have good prognosis
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Patients with late-onset idiopathic scoliosis have only a modest increase in health problems compared with patients without scoliosis. Clinicians should keep this in mind when providing health education and offer reassurance and watchful waiting to patients with small curves at skeletal maturity.

More broadly, whether to screen for scoliosis depends on the performance of the screening test as well as evidence of whether treatment alters the natural history of scoliosis. The US Preventive Services Task Force has concluded that there is insufficient evidence to recommend routine screening.1

 
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Weinstein SL, Dolan LA, Spratt KF, Peterson KK, Spoonamore MJ, Ponsetti IV. Health and function of patients with untreated idiopathic scoliosis. JAMA 2003; 289:559–567.

Melissa Gilmer-Scott, MD
Warren , MD, MPH
Department of Family Medicine, University of North Carolina, Chapel Hill. E-mail: [email protected].

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Weinstein SL, Dolan LA, Spratt KF, Peterson KK, Spoonamore MJ, Ponsetti IV. Health and function of patients with untreated idiopathic scoliosis. JAMA 2003; 289:559–567.

Melissa Gilmer-Scott, MD
Warren , MD, MPH
Department of Family Medicine, University of North Carolina, Chapel Hill. E-mail: [email protected].

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Weinstein SL, Dolan LA, Spratt KF, Peterson KK, Spoonamore MJ, Ponsetti IV. Health and function of patients with untreated idiopathic scoliosis. JAMA 2003; 289:559–567.

Melissa Gilmer-Scott, MD
Warren , MD, MPH
Department of Family Medicine, University of North Carolina, Chapel Hill. E-mail: [email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Patients with late-onset idiopathic scoliosis have only a modest increase in health problems compared with patients without scoliosis. Clinicians should keep this in mind when providing health education and offer reassurance and watchful waiting to patients with small curves at skeletal maturity.

More broadly, whether to screen for scoliosis depends on the performance of the screening test as well as evidence of whether treatment alters the natural history of scoliosis. The US Preventive Services Task Force has concluded that there is insufficient evidence to recommend routine screening.1

 
PRACTICE RECOMMENDATIONS

Patients with late-onset idiopathic scoliosis have only a modest increase in health problems compared with patients without scoliosis. Clinicians should keep this in mind when providing health education and offer reassurance and watchful waiting to patients with small curves at skeletal maturity.

More broadly, whether to screen for scoliosis depends on the performance of the screening test as well as evidence of whether treatment alters the natural history of scoliosis. The US Preventive Services Task Force has concluded that there is insufficient evidence to recommend routine screening.1

 
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Topical ophthalmic NSAIDs reduce pain faster than placebo

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Topical ophthalmic NSAIDs reduce pain faster than placebo
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Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) relieve the pain of uncomplicated acute corneal abrasions faster than placebo eyedrops.

The pain relief is small; whether the pain relief difference would be noticed by patients and how it compares with oral analgesics is unknown. Given the cost of topical NSAIDs, they are most useful for a select patient population: those who must return to work immediately, and those for whom opioid analgesia-induced sedation is intolerable.

 
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Weaver CS, Terrell KM. Update: Do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing? Ann Emerg Med 2003; 41:134–140.

Bruce R. Deschere, MD, MSBA
Kendra Schwartz, MD, MSPH
Department of Family Medicine, Wayne State University, Detroit, Mich. E-mail: [email protected].

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Weaver CS, Terrell KM. Update: Do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing? Ann Emerg Med 2003; 41:134–140.

Bruce R. Deschere, MD, MSBA
Kendra Schwartz, MD, MSPH
Department of Family Medicine, Wayne State University, Detroit, Mich. E-mail: [email protected].

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Weaver CS, Terrell KM. Update: Do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing? Ann Emerg Med 2003; 41:134–140.

Bruce R. Deschere, MD, MSBA
Kendra Schwartz, MD, MSPH
Department of Family Medicine, Wayne State University, Detroit, Mich. E-mail: [email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) relieve the pain of uncomplicated acute corneal abrasions faster than placebo eyedrops.

The pain relief is small; whether the pain relief difference would be noticed by patients and how it compares with oral analgesics is unknown. Given the cost of topical NSAIDs, they are most useful for a select patient population: those who must return to work immediately, and those for whom opioid analgesia-induced sedation is intolerable.

 
PRACTICE RECOMMENDATIONS

Topical ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) relieve the pain of uncomplicated acute corneal abrasions faster than placebo eyedrops.

The pain relief is small; whether the pain relief difference would be noticed by patients and how it compares with oral analgesics is unknown. Given the cost of topical NSAIDs, they are most useful for a select patient population: those who must return to work immediately, and those for whom opioid analgesia-induced sedation is intolerable.

 
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Topical ophthalmic NSAIDs reduce pain faster than placebo
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Admission electronic fetal monitoring does not improve neonatal outcomes

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Admission electronic fetal monitoring does not improve neonatal outcomes
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Admission electronic fetal monitoring did not decrease neonatal morbidity and mortality compared with intermittent auscultation.

Patients in the admission fetal monitoring group were more likely to receive continuous electronic monitoring and fetal blood sampling, but there were no significant differences in the rates of operative deliveries or episiotomy. Institutions not routinely using admission electronic fetal monitoring should not start; those that do may not be benefiting their patients.

 
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Impey L, Reynolds M, MacQuillan K, Gates S, Murphy J, Sheil O. Admission cardiotocography: a randomized trial. Lancet 2003;361:465–470.

Charles Cole, MD
Department of Family Medicine, University of Virginia Health Sciences Center, Charlottesville; Stoney Creek Family Practice, Nellysford, Va. E-mail: [email protected].

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Impey L, Reynolds M, MacQuillan K, Gates S, Murphy J, Sheil O. Admission cardiotocography: a randomized trial. Lancet 2003;361:465–470.

Charles Cole, MD
Department of Family Medicine, University of Virginia Health Sciences Center, Charlottesville; Stoney Creek Family Practice, Nellysford, Va. E-mail: [email protected].

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Impey L, Reynolds M, MacQuillan K, Gates S, Murphy J, Sheil O. Admission cardiotocography: a randomized trial. Lancet 2003;361:465–470.

Charles Cole, MD
Department of Family Medicine, University of Virginia Health Sciences Center, Charlottesville; Stoney Creek Family Practice, Nellysford, Va. E-mail: [email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Admission electronic fetal monitoring did not decrease neonatal morbidity and mortality compared with intermittent auscultation.

Patients in the admission fetal monitoring group were more likely to receive continuous electronic monitoring and fetal blood sampling, but there were no significant differences in the rates of operative deliveries or episiotomy. Institutions not routinely using admission electronic fetal monitoring should not start; those that do may not be benefiting their patients.

 
PRACTICE RECOMMENDATIONS

Admission electronic fetal monitoring did not decrease neonatal morbidity and mortality compared with intermittent auscultation.

Patients in the admission fetal monitoring group were more likely to receive continuous electronic monitoring and fetal blood sampling, but there were no significant differences in the rates of operative deliveries or episiotomy. Institutions not routinely using admission electronic fetal monitoring should not start; those that do may not be benefiting their patients.

 
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Cognitive behavioral therapy and exercise minimally help Gulf War veterans’ illnesses

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Cognitive behavioral therapy and exercise minimally help Gulf War veterans’ illnesses
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Cognitive behavioral therapy and aerobic exercise provide only modest relief from symptoms of Gulf War veterans’ illnesses. Unfortunately, over 80% of the patients showed no improvement of symptoms after 1 year of either or both treatments. With the Iraqi war ending, the outcomes of veterans of this previous conflict may prove significant.

 
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Donta ST, Clauw DJ, Engel CC et al. Cognitive behavioral therapy and aerobic exercise for Gulf War veterans’ illnesses: A randomized controlled trial. JAMA 2003; 289;1396–1404.

Gary Luttermoser, MD
Harrisburg Family Practice Residency Program, Harrisburg, Pa. E-mail: [email protected].

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Donta ST, Clauw DJ, Engel CC et al. Cognitive behavioral therapy and aerobic exercise for Gulf War veterans’ illnesses: A randomized controlled trial. JAMA 2003; 289;1396–1404.

Gary Luttermoser, MD
Harrisburg Family Practice Residency Program, Harrisburg, Pa. E-mail: [email protected].

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Donta ST, Clauw DJ, Engel CC et al. Cognitive behavioral therapy and aerobic exercise for Gulf War veterans’ illnesses: A randomized controlled trial. JAMA 2003; 289;1396–1404.

Gary Luttermoser, MD
Harrisburg Family Practice Residency Program, Harrisburg, Pa. E-mail: [email protected].

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Cognitive behavioral therapy and aerobic exercise provide only modest relief from symptoms of Gulf War veterans’ illnesses. Unfortunately, over 80% of the patients showed no improvement of symptoms after 1 year of either or both treatments. With the Iraqi war ending, the outcomes of veterans of this previous conflict may prove significant.

 
PRACTICE RECOMMENDATIONS

Cognitive behavioral therapy and aerobic exercise provide only modest relief from symptoms of Gulf War veterans’ illnesses. Unfortunately, over 80% of the patients showed no improvement of symptoms after 1 year of either or both treatments. With the Iraqi war ending, the outcomes of veterans of this previous conflict may prove significant.

 
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Not all fish products prevent heart disease

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Not all fish products prevent heart disease
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For patients aged >65 years, modest consumption of tuna and other broiled/baked fish is associated with a lower risk of death from ischemic heart disease and fatal arrhythmias. The same is not true of fried fish or fish burgers. Instruct patients that not all fish products provide the same health effects.

 
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Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS. Cardiac benefits of fish consumption may depend on the type of fish meal consumed. Circulation 2003; 107:1372–1377.

Andrew R. Lockman, MD
Department of Family Medicine, University of Virginia Health System, Charlottesville, Va. E-mail: [email protected].

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Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS. Cardiac benefits of fish consumption may depend on the type of fish meal consumed. Circulation 2003; 107:1372–1377.

Andrew R. Lockman, MD
Department of Family Medicine, University of Virginia Health System, Charlottesville, Va. E-mail: [email protected].

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Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS. Cardiac benefits of fish consumption may depend on the type of fish meal consumed. Circulation 2003; 107:1372–1377.

Andrew R. Lockman, MD
Department of Family Medicine, University of Virginia Health System, Charlottesville, Va. E-mail: [email protected].

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PRACTICE RECOMMENDATIONS

For patients aged >65 years, modest consumption of tuna and other broiled/baked fish is associated with a lower risk of death from ischemic heart disease and fatal arrhythmias. The same is not true of fried fish or fish burgers. Instruct patients that not all fish products provide the same health effects.

 
PRACTICE RECOMMENDATIONS

For patients aged >65 years, modest consumption of tuna and other broiled/baked fish is associated with a lower risk of death from ischemic heart disease and fatal arrhythmias. The same is not true of fried fish or fish burgers. Instruct patients that not all fish products provide the same health effects.

 
Issue
The Journal of Family Practice - 52(6)
Issue
The Journal of Family Practice - 52(6)
Page Number
431-454
Page Number
431-454
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Publications
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Not all fish products prevent heart disease
Display Headline
Not all fish products prevent heart disease
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