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Point-Counterpoint: Hospital-acquired infections: Is getting to zero the right medicine?

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Point-Counterpoint: Hospital-acquired infections: Is getting to zero the right medicine?

YES – Eliminating HAIs is feasible and may help better focus prevention efforts.

For many years, research suggested that reducing hospital-acquired infections (HAIs) by one-third was the best we could do. But recent landmark efforts, such as the Pittsburgh Regional Healthcare Initiative (Morb. Mortal. Wkly. Rep. 2005;54:1013-16) and the Michigan Keystone Project (N. Engl. J. Med. 2006;355:2725-32), have shattered our notions of how many HAIs might be preventable, achieving reductions of nearly 70% in central line–associated bloodstream infections (CLABSIs). Similarly, a national campaign in England has achieved a 68% reduction in Clostridium difficile infections (Health Prot. Rep. 2012;6:38).

Dr. Arjun Srinivasan

These new data suggest that possibly all HAIs are preventable, and there are now many published reports in which institutions have reached zero. For example, the Hawaii experience has shown that a prevention initiative achieved a median rate of zero catheter-related bloodstream infections (Am. J. Med. Qual. 2012;27:124-9).

The advances in HAI prevention are coming in the context of an ever increasingly sick patient population, with patients who are more complicated than ever before. In fact, many of the greatest gains in CLABSI prevention have been among the very sickest patients in our hospitals – in the intensive care unit – as at the Johns Hopkins Hospital in Baltimore (Crit. Care Med. 2004;32:2014-20). So the rationale that we cannot get to zero because our patients are too sick simply is not relevant anymore.

We won’t know how many HAIs are preventable until we hit the bottom. But if our goal is not zero, we will likely end up accepting some infections that might be preventable. Therefore, we must set the goal at zero infections.

What if we don’t get there? That would suggest that some of these infections might not be related to health care delivery but rather to patient risk factors. And these are the infections that we can target. New research could end up preventing some of them. Modifications in definitions might be necessary to account for some of these infections.

One might then argue that we are just defining our way to zero. I would counter that plenty of places have, in fact, hit zero CLABSIs without any changes in our current definitions. But I will also argue that rational changes in our definitions will be needed to help us differentiate truly preventable HAIs and allow us to better focus our prevention efforts.

An excellent example is the new definition of the mucosal barrier injury–related bloodstream infections, which was discussed during the recent IDWeek. Making such an evidence-based change to a definition to focus prevention efforts is neither gaming nor cheating—it’s called good science and good policy.

The zero goal will also improve medical care through the wider adoption of best practices. Published reports of HAI prevention efforts show the successes have been obtained through the implementation of best practices, not through gaming, not through cheating. Zero HAIs as a goal is already driving real improvements in patient safety and quality.

Pushing for zero HAIs will also further research. How much can we argue for pushing the prevention research envelope if we decide that some of these infections are simply okay? How are we going to argue for funding for more prevention research if we tell them the infections aren’t really preventable? We will be much more successful if it’s clear that we need it to get to zero HAIs.

Getting to zero has been put forth as a goal that we should aim for, not as a standard that people should be punished for in the event it is not attained. In fact, value-based purchasing rules are based on relative infection rates – not on zero infection rates.

Moreover, it’s a long-range goal. This is not something that anyone is advocating for overnight. Evidence of that can be seen in the National Action Plan to Prevent HAIs, which calls for 30%-50% reductions, not zero, as the target for the first 5 years.

It must be acknowledged that sometimes an HAI is someone’s fault. Many U.S. institutions have yet to implement best practices for preventing CLABSIs, for example. How long can we hold these hospitals blameless for failing to do this?

In sum, getting to zero HAIs is not the right medicine, but the only medicine. It is our successes, published in our own medical literature, that have prompted the push to get to zero. We shouldn’t run away from the success that we have had; we should embrace it and build on it. Patients will no longer accept a goal of preventing some HAIs, and neither should we.

 

 

Dr. Srinivasan is associate director for health care–associated infection prevention programs, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention. He disclosed no relevant conflicts of interest.

NO – Eliminating HAIs is unrealistic and has unintended negative consequences.

There are a variety of reasons why getting to zero HAIs is not the right medicine. First and probably most important is that it is dishonest. Patients today are sicker and more immunosuppressed, and the devices we use are ever more invasive. When we have patients in our hospitals who, for example, have total artificial hearts in place for more than a year, can we realistically imagine that there would not be any HAIs? I don’t think so.

Extensive medical literature documenting infection prevention initiatives attests to this. For example, a recent analysis suggests that even if all U.S. hospitals implemented all of the measures known to prevent HAIs, at best 55%-70% of common HAIs would reasonably be preventable (Infect. Control Hosp. Epidemiol. 2011;32:101-14). None were found to be 100% preventable.

Dr. Michael Edmond

If one looks closely at the Hawaii experience showing a median rate of zero HAIs, you actually see a 61% reduction in the rate of CLABSIs over 1.5 years, but it never reaches zero (Am. J. Med. Qual. 2012;27:124-9). That translates to up to 10 infections per quarter. So we can use words in loose ways and talk about zero median infections, but there were not zero infections in that study. If the final rate of 0.6/1,000 catheter-days were applied to my hospital, it would translate to 11 CLABSIs annually – hardly a number that would allow me to say I had eliminated these infections.

Efforts to achieve zero HAIs may be a manifestation of postmodernism, a philosophical paradigm in which there is no absolute truth, and one that puts evidence-based medicine on par with practices such as homeopathy and the notion that the measles, mumps, and rubella vaccine causes autism.

Aiming for zero HAIs drives a punitive culture. If we accept the concept of getting to zero, it then means that zero is actually attainable, and if that is true, then all HAIs are preventable. And if that is true, logic tells us then that the occurrence of an HAI must be someone’s fault.

The zero goal places enormous pressure on infection preventionists and their programs, and it creates adversarial relationships between infection prevention services and clinicians as they argue about whether an event is an infection. Hospital administrators ask why programs are not reaching zero. And the infection prevention people are caught in the middle of all this. They are in a terrible position: In some cases, they are deciding – in a way – whether people will get a pay raise or will be fired from their jobs.

Trying to eliminate HAIs fosters problems with surveillance, such as outright cheating, making subtle changes to case definitions that reduce infection rates, and underfunding infection prevention programs to reduce their sensitivity for case ascertainment.

It also leads to inappropriate medical practices. For example, many hospitals now check urine cultures on admission in patients with urinary catheters, or obtain blood cultures on asymptomatic patients simply because they have a central line. We know what those kinds of practices lead to nonindicated treatment and overuse of antibiotics.

Aiming for zero separates infection prevention from quality and safety because now, the "be all, end all" becomes an infection-free hospital stay, when maybe that is not the main goal from a patient perspective.

The zero goal also fosters expedient solutions over the hard work of behavior change. A report predicts that, in 2016, the market for infection-control devices and products will be $18 billion – triple that of the market for antibiotics to treat those infections. So there’s a lot of industry out there waiting to get into the market. That in turn contributes to a conflict of interest. Some leading infectious disease associations now have strong sponsorship from these industries that is likely not serving us well.

Aiming for zero also punishes hospitals that care for poor and sicker patients. As an example, in public reporting of hospitals’ infection rates, academic medical centers may appear to have comparatively worse performance.

Finally, if we already know how to get to zero, why would we ever invest any more in research to reduce infections? It really weakens the rationale for funding in the whole field of HAI prevention.

In sum, getting to zero HAIs is not a realistic or beneficial goal and may actually produce many unintended negative consequences. Clinicians and patients alike would be better served by a focus on achieving realistic reductions.

 

 

Dr. Edmond is the Richard P. Wenzel Professor of Internal Medicine and chair of the infectious diseases division, Virginia Commonwealth University Hospital, and an epidemiologist at the VCU Health System, both in Richmond. He disclosed no relevant conflicts of interest.

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YES – Eliminating HAIs is feasible and may help better focus prevention efforts.

For many years, research suggested that reducing hospital-acquired infections (HAIs) by one-third was the best we could do. But recent landmark efforts, such as the Pittsburgh Regional Healthcare Initiative (Morb. Mortal. Wkly. Rep. 2005;54:1013-16) and the Michigan Keystone Project (N. Engl. J. Med. 2006;355:2725-32), have shattered our notions of how many HAIs might be preventable, achieving reductions of nearly 70% in central line–associated bloodstream infections (CLABSIs). Similarly, a national campaign in England has achieved a 68% reduction in Clostridium difficile infections (Health Prot. Rep. 2012;6:38).

Dr. Arjun Srinivasan

These new data suggest that possibly all HAIs are preventable, and there are now many published reports in which institutions have reached zero. For example, the Hawaii experience has shown that a prevention initiative achieved a median rate of zero catheter-related bloodstream infections (Am. J. Med. Qual. 2012;27:124-9).

The advances in HAI prevention are coming in the context of an ever increasingly sick patient population, with patients who are more complicated than ever before. In fact, many of the greatest gains in CLABSI prevention have been among the very sickest patients in our hospitals – in the intensive care unit – as at the Johns Hopkins Hospital in Baltimore (Crit. Care Med. 2004;32:2014-20). So the rationale that we cannot get to zero because our patients are too sick simply is not relevant anymore.

We won’t know how many HAIs are preventable until we hit the bottom. But if our goal is not zero, we will likely end up accepting some infections that might be preventable. Therefore, we must set the goal at zero infections.

What if we don’t get there? That would suggest that some of these infections might not be related to health care delivery but rather to patient risk factors. And these are the infections that we can target. New research could end up preventing some of them. Modifications in definitions might be necessary to account for some of these infections.

One might then argue that we are just defining our way to zero. I would counter that plenty of places have, in fact, hit zero CLABSIs without any changes in our current definitions. But I will also argue that rational changes in our definitions will be needed to help us differentiate truly preventable HAIs and allow us to better focus our prevention efforts.

An excellent example is the new definition of the mucosal barrier injury–related bloodstream infections, which was discussed during the recent IDWeek. Making such an evidence-based change to a definition to focus prevention efforts is neither gaming nor cheating—it’s called good science and good policy.

The zero goal will also improve medical care through the wider adoption of best practices. Published reports of HAI prevention efforts show the successes have been obtained through the implementation of best practices, not through gaming, not through cheating. Zero HAIs as a goal is already driving real improvements in patient safety and quality.

Pushing for zero HAIs will also further research. How much can we argue for pushing the prevention research envelope if we decide that some of these infections are simply okay? How are we going to argue for funding for more prevention research if we tell them the infections aren’t really preventable? We will be much more successful if it’s clear that we need it to get to zero HAIs.

Getting to zero has been put forth as a goal that we should aim for, not as a standard that people should be punished for in the event it is not attained. In fact, value-based purchasing rules are based on relative infection rates – not on zero infection rates.

Moreover, it’s a long-range goal. This is not something that anyone is advocating for overnight. Evidence of that can be seen in the National Action Plan to Prevent HAIs, which calls for 30%-50% reductions, not zero, as the target for the first 5 years.

It must be acknowledged that sometimes an HAI is someone’s fault. Many U.S. institutions have yet to implement best practices for preventing CLABSIs, for example. How long can we hold these hospitals blameless for failing to do this?

In sum, getting to zero HAIs is not the right medicine, but the only medicine. It is our successes, published in our own medical literature, that have prompted the push to get to zero. We shouldn’t run away from the success that we have had; we should embrace it and build on it. Patients will no longer accept a goal of preventing some HAIs, and neither should we.

 

 

Dr. Srinivasan is associate director for health care–associated infection prevention programs, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention. He disclosed no relevant conflicts of interest.

NO – Eliminating HAIs is unrealistic and has unintended negative consequences.

There are a variety of reasons why getting to zero HAIs is not the right medicine. First and probably most important is that it is dishonest. Patients today are sicker and more immunosuppressed, and the devices we use are ever more invasive. When we have patients in our hospitals who, for example, have total artificial hearts in place for more than a year, can we realistically imagine that there would not be any HAIs? I don’t think so.

Extensive medical literature documenting infection prevention initiatives attests to this. For example, a recent analysis suggests that even if all U.S. hospitals implemented all of the measures known to prevent HAIs, at best 55%-70% of common HAIs would reasonably be preventable (Infect. Control Hosp. Epidemiol. 2011;32:101-14). None were found to be 100% preventable.

Dr. Michael Edmond

If one looks closely at the Hawaii experience showing a median rate of zero HAIs, you actually see a 61% reduction in the rate of CLABSIs over 1.5 years, but it never reaches zero (Am. J. Med. Qual. 2012;27:124-9). That translates to up to 10 infections per quarter. So we can use words in loose ways and talk about zero median infections, but there were not zero infections in that study. If the final rate of 0.6/1,000 catheter-days were applied to my hospital, it would translate to 11 CLABSIs annually – hardly a number that would allow me to say I had eliminated these infections.

Efforts to achieve zero HAIs may be a manifestation of postmodernism, a philosophical paradigm in which there is no absolute truth, and one that puts evidence-based medicine on par with practices such as homeopathy and the notion that the measles, mumps, and rubella vaccine causes autism.

Aiming for zero HAIs drives a punitive culture. If we accept the concept of getting to zero, it then means that zero is actually attainable, and if that is true, then all HAIs are preventable. And if that is true, logic tells us then that the occurrence of an HAI must be someone’s fault.

The zero goal places enormous pressure on infection preventionists and their programs, and it creates adversarial relationships between infection prevention services and clinicians as they argue about whether an event is an infection. Hospital administrators ask why programs are not reaching zero. And the infection prevention people are caught in the middle of all this. They are in a terrible position: In some cases, they are deciding – in a way – whether people will get a pay raise or will be fired from their jobs.

Trying to eliminate HAIs fosters problems with surveillance, such as outright cheating, making subtle changes to case definitions that reduce infection rates, and underfunding infection prevention programs to reduce their sensitivity for case ascertainment.

It also leads to inappropriate medical practices. For example, many hospitals now check urine cultures on admission in patients with urinary catheters, or obtain blood cultures on asymptomatic patients simply because they have a central line. We know what those kinds of practices lead to nonindicated treatment and overuse of antibiotics.

Aiming for zero separates infection prevention from quality and safety because now, the "be all, end all" becomes an infection-free hospital stay, when maybe that is not the main goal from a patient perspective.

The zero goal also fosters expedient solutions over the hard work of behavior change. A report predicts that, in 2016, the market for infection-control devices and products will be $18 billion – triple that of the market for antibiotics to treat those infections. So there’s a lot of industry out there waiting to get into the market. That in turn contributes to a conflict of interest. Some leading infectious disease associations now have strong sponsorship from these industries that is likely not serving us well.

Aiming for zero also punishes hospitals that care for poor and sicker patients. As an example, in public reporting of hospitals’ infection rates, academic medical centers may appear to have comparatively worse performance.

Finally, if we already know how to get to zero, why would we ever invest any more in research to reduce infections? It really weakens the rationale for funding in the whole field of HAI prevention.

In sum, getting to zero HAIs is not a realistic or beneficial goal and may actually produce many unintended negative consequences. Clinicians and patients alike would be better served by a focus on achieving realistic reductions.

 

 

Dr. Edmond is the Richard P. Wenzel Professor of Internal Medicine and chair of the infectious diseases division, Virginia Commonwealth University Hospital, and an epidemiologist at the VCU Health System, both in Richmond. He disclosed no relevant conflicts of interest.

YES – Eliminating HAIs is feasible and may help better focus prevention efforts.

For many years, research suggested that reducing hospital-acquired infections (HAIs) by one-third was the best we could do. But recent landmark efforts, such as the Pittsburgh Regional Healthcare Initiative (Morb. Mortal. Wkly. Rep. 2005;54:1013-16) and the Michigan Keystone Project (N. Engl. J. Med. 2006;355:2725-32), have shattered our notions of how many HAIs might be preventable, achieving reductions of nearly 70% in central line–associated bloodstream infections (CLABSIs). Similarly, a national campaign in England has achieved a 68% reduction in Clostridium difficile infections (Health Prot. Rep. 2012;6:38).

Dr. Arjun Srinivasan

These new data suggest that possibly all HAIs are preventable, and there are now many published reports in which institutions have reached zero. For example, the Hawaii experience has shown that a prevention initiative achieved a median rate of zero catheter-related bloodstream infections (Am. J. Med. Qual. 2012;27:124-9).

The advances in HAI prevention are coming in the context of an ever increasingly sick patient population, with patients who are more complicated than ever before. In fact, many of the greatest gains in CLABSI prevention have been among the very sickest patients in our hospitals – in the intensive care unit – as at the Johns Hopkins Hospital in Baltimore (Crit. Care Med. 2004;32:2014-20). So the rationale that we cannot get to zero because our patients are too sick simply is not relevant anymore.

We won’t know how many HAIs are preventable until we hit the bottom. But if our goal is not zero, we will likely end up accepting some infections that might be preventable. Therefore, we must set the goal at zero infections.

What if we don’t get there? That would suggest that some of these infections might not be related to health care delivery but rather to patient risk factors. And these are the infections that we can target. New research could end up preventing some of them. Modifications in definitions might be necessary to account for some of these infections.

One might then argue that we are just defining our way to zero. I would counter that plenty of places have, in fact, hit zero CLABSIs without any changes in our current definitions. But I will also argue that rational changes in our definitions will be needed to help us differentiate truly preventable HAIs and allow us to better focus our prevention efforts.

An excellent example is the new definition of the mucosal barrier injury–related bloodstream infections, which was discussed during the recent IDWeek. Making such an evidence-based change to a definition to focus prevention efforts is neither gaming nor cheating—it’s called good science and good policy.

The zero goal will also improve medical care through the wider adoption of best practices. Published reports of HAI prevention efforts show the successes have been obtained through the implementation of best practices, not through gaming, not through cheating. Zero HAIs as a goal is already driving real improvements in patient safety and quality.

Pushing for zero HAIs will also further research. How much can we argue for pushing the prevention research envelope if we decide that some of these infections are simply okay? How are we going to argue for funding for more prevention research if we tell them the infections aren’t really preventable? We will be much more successful if it’s clear that we need it to get to zero HAIs.

Getting to zero has been put forth as a goal that we should aim for, not as a standard that people should be punished for in the event it is not attained. In fact, value-based purchasing rules are based on relative infection rates – not on zero infection rates.

Moreover, it’s a long-range goal. This is not something that anyone is advocating for overnight. Evidence of that can be seen in the National Action Plan to Prevent HAIs, which calls for 30%-50% reductions, not zero, as the target for the first 5 years.

It must be acknowledged that sometimes an HAI is someone’s fault. Many U.S. institutions have yet to implement best practices for preventing CLABSIs, for example. How long can we hold these hospitals blameless for failing to do this?

In sum, getting to zero HAIs is not the right medicine, but the only medicine. It is our successes, published in our own medical literature, that have prompted the push to get to zero. We shouldn’t run away from the success that we have had; we should embrace it and build on it. Patients will no longer accept a goal of preventing some HAIs, and neither should we.

 

 

Dr. Srinivasan is associate director for health care–associated infection prevention programs, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention. He disclosed no relevant conflicts of interest.

NO – Eliminating HAIs is unrealistic and has unintended negative consequences.

There are a variety of reasons why getting to zero HAIs is not the right medicine. First and probably most important is that it is dishonest. Patients today are sicker and more immunosuppressed, and the devices we use are ever more invasive. When we have patients in our hospitals who, for example, have total artificial hearts in place for more than a year, can we realistically imagine that there would not be any HAIs? I don’t think so.

Extensive medical literature documenting infection prevention initiatives attests to this. For example, a recent analysis suggests that even if all U.S. hospitals implemented all of the measures known to prevent HAIs, at best 55%-70% of common HAIs would reasonably be preventable (Infect. Control Hosp. Epidemiol. 2011;32:101-14). None were found to be 100% preventable.

Dr. Michael Edmond

If one looks closely at the Hawaii experience showing a median rate of zero HAIs, you actually see a 61% reduction in the rate of CLABSIs over 1.5 years, but it never reaches zero (Am. J. Med. Qual. 2012;27:124-9). That translates to up to 10 infections per quarter. So we can use words in loose ways and talk about zero median infections, but there were not zero infections in that study. If the final rate of 0.6/1,000 catheter-days were applied to my hospital, it would translate to 11 CLABSIs annually – hardly a number that would allow me to say I had eliminated these infections.

Efforts to achieve zero HAIs may be a manifestation of postmodernism, a philosophical paradigm in which there is no absolute truth, and one that puts evidence-based medicine on par with practices such as homeopathy and the notion that the measles, mumps, and rubella vaccine causes autism.

Aiming for zero HAIs drives a punitive culture. If we accept the concept of getting to zero, it then means that zero is actually attainable, and if that is true, then all HAIs are preventable. And if that is true, logic tells us then that the occurrence of an HAI must be someone’s fault.

The zero goal places enormous pressure on infection preventionists and their programs, and it creates adversarial relationships between infection prevention services and clinicians as they argue about whether an event is an infection. Hospital administrators ask why programs are not reaching zero. And the infection prevention people are caught in the middle of all this. They are in a terrible position: In some cases, they are deciding – in a way – whether people will get a pay raise or will be fired from their jobs.

Trying to eliminate HAIs fosters problems with surveillance, such as outright cheating, making subtle changes to case definitions that reduce infection rates, and underfunding infection prevention programs to reduce their sensitivity for case ascertainment.

It also leads to inappropriate medical practices. For example, many hospitals now check urine cultures on admission in patients with urinary catheters, or obtain blood cultures on asymptomatic patients simply because they have a central line. We know what those kinds of practices lead to nonindicated treatment and overuse of antibiotics.

Aiming for zero separates infection prevention from quality and safety because now, the "be all, end all" becomes an infection-free hospital stay, when maybe that is not the main goal from a patient perspective.

The zero goal also fosters expedient solutions over the hard work of behavior change. A report predicts that, in 2016, the market for infection-control devices and products will be $18 billion – triple that of the market for antibiotics to treat those infections. So there’s a lot of industry out there waiting to get into the market. That in turn contributes to a conflict of interest. Some leading infectious disease associations now have strong sponsorship from these industries that is likely not serving us well.

Aiming for zero also punishes hospitals that care for poor and sicker patients. As an example, in public reporting of hospitals’ infection rates, academic medical centers may appear to have comparatively worse performance.

Finally, if we already know how to get to zero, why would we ever invest any more in research to reduce infections? It really weakens the rationale for funding in the whole field of HAI prevention.

In sum, getting to zero HAIs is not a realistic or beneficial goal and may actually produce many unintended negative consequences. Clinicians and patients alike would be better served by a focus on achieving realistic reductions.

 

 

Dr. Edmond is the Richard P. Wenzel Professor of Internal Medicine and chair of the infectious diseases division, Virginia Commonwealth University Hospital, and an epidemiologist at the VCU Health System, both in Richmond. He disclosed no relevant conflicts of interest.

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Laparoscopic diverticulitis surgery linked to fewer complications

Analysis fails to account for possible confounders
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Laparoscopic diverticulitis surgery linked to fewer complications

PALM BEACH, FLA.– Using laparoscopic surgery for colectomy with primary anastomosis in patients with complicated diverticulitis linked with significantly fewer major complications compared with open surgical management in a review of more than 10,000 patients from a nationwide database.

However, the inherent biases at play when surgeons decide whether to manage a diverticulitis patient by a laparoscopic or open approach make it difficult to draw definitive conclusions from the findings, Dr. Edward E. Cornwell III said at the annual meeting of the Southern Surgical Association.

Dr. Edward E. Cornwell, III

"If a surgeon did an operation laparoscopically, that by itself is an indicator of how sick the patient was. The surgeon selects an open operation for sicker patients, and laparoscopy for the less sick patients," he said in an interview. "Have we accounted for that difference [in the analysis]? That’s an open question," said Dr. Cornwell, professor and chairman of surgery at Howard University in Washington.

"Patients whom the surgeon deem well enough physiologically to sustain colectomy with primary anastomosis deserve strong consideration for the laparoscopic approach because those patients had the greatest difference in complications" compared with open surgery, he said.

The data Dr. Cornwell and his associates reviewed also showed a marked skewing in how surgeons used laparoscopy. Among the 10,085 patients included in the analysis, 7,562 (75%) underwent colectomy with primary anastomosis, and in this subgroup, 5,105 patients (68%) had their surgery done laparoscopically, while the remaining 2,457 (32%) were done with open surgery. In contrast, the 2,523 other patients in the series underwent a colectomy with colostomy, and within this subgroup, 2,286 patients (91%) had open surgery, with only 237 (9%) having laparoscopic surgery.

The overwhelming use of open surgery for the colostomy patients makes sense as it is a more complex operation, Dr. Cornwell said.

He and his associates used data collected during 2005-2009 at 237 U.S. hospitals by the National Surgical Quality Improvement Program of the American College of Surgeons on patients who underwent surgical management of complicated diverticulitis. The average age of the patients was 58 years, and overall 30-day mortality was 2%, while the overall postoperative complication rate during the 30 days following surgery was 23%.

Among the patients who underwent a primary anastomosis, the incidence of major complications during 30 days of follow-up was 13% in the open surgery patients and 6% in the laparoscopy patients, a statistically significant difference. Major complications included surgical site infections, dehiscence, transfusion, respiratory failure, sepsis, myocardial infarction, pulmonary embolism, stroke, renal failure or need for rehospitalization.

In a multivariate analysis that controlled for demographic parameters, body mass index, comorbidities, and functional status, patients who underwent laparoscopy had about half the number of total complications and major complications compared with patients who underwent open surgery – statistically significant differences. The laparoscopically-treated patients also had roughly half the rate of several individual major complications – wound infections, respiratory complications, and sepsis – compared with the open surgery patients, all statistically significant differences.

Thirty-day mortality was about 50% lower with laparoscopy compared with open surgery among patients who underwent a primary anastomosis, but this difference fell short of statistical significance.

The advantage of laparoscopy over open surgery was not nearly so clear among patients who underwent colectomy with colostomy. The data showed no significant difference between laparoscopy and open surgery in the rate of all major complications, although the number of major complications with laparoscopy was about 20% lower. The only individual complications significantly reduced in the laparoscopy group were wound infections, reduced by about 40% in the adjusted analysis, and respiratory complications, cut by about 50% by laparoscopy. The two surgical subgroups showed virtually no difference in 30-day mortality among patients who underwent a colectomy.

The results suggest that because of the broad reduction of major complications with laparoscopy, this approach "should be considered when primary anastomosis is deemed appropriate," Dr. Cornwell concluded.

Dr. Cornwell said that he had no disclosures.

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This work falls somewhat short of actually comparing the efficacy of the laparoscopic approach and open surgery in patients with complicated diverticulitis. Without an adequate standardized description of the disease process itself, the patients’ comorbidities, and their physiologic perturbation at the time of presentation, it is exceedingly difficult to measure outcomes and the efficacy of therapeutic interventions.

I’m afraid the authors have not satisfactorily controlled for or analyzed the confounding factors so that plausible conclusions can be reached. The results are striking that mortality and complications were higher for patients treated with open surgery. I have watched the evolution of laparoscopic surgery over the past 25 years, and I am convinced that patients greatly benefit from this technology.

While the laparoscopic approach for treating diverticulitis resonates with my sensibility, the data do not support a clear recommendation. I urge surgeons to focus on this emergency, general-surgery population so that we can do important comparative effectiveness research and address some of these questions.

Dr. Michael F. Rotondo is professor and chairman of surgery at East Carolina University in Greenville, N.C. He had no disclosures. He made these comments as a designated discussant of the report.

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laparoscopic diverticulitis surgery, colectomy with primary anastomosis, diverticulitis patients, open surgical management
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Body

This work falls somewhat short of actually comparing the efficacy of the laparoscopic approach and open surgery in patients with complicated diverticulitis. Without an adequate standardized description of the disease process itself, the patients’ comorbidities, and their physiologic perturbation at the time of presentation, it is exceedingly difficult to measure outcomes and the efficacy of therapeutic interventions.

I’m afraid the authors have not satisfactorily controlled for or analyzed the confounding factors so that plausible conclusions can be reached. The results are striking that mortality and complications were higher for patients treated with open surgery. I have watched the evolution of laparoscopic surgery over the past 25 years, and I am convinced that patients greatly benefit from this technology.

While the laparoscopic approach for treating diverticulitis resonates with my sensibility, the data do not support a clear recommendation. I urge surgeons to focus on this emergency, general-surgery population so that we can do important comparative effectiveness research and address some of these questions.

Dr. Michael F. Rotondo is professor and chairman of surgery at East Carolina University in Greenville, N.C. He had no disclosures. He made these comments as a designated discussant of the report.

Body

This work falls somewhat short of actually comparing the efficacy of the laparoscopic approach and open surgery in patients with complicated diverticulitis. Without an adequate standardized description of the disease process itself, the patients’ comorbidities, and their physiologic perturbation at the time of presentation, it is exceedingly difficult to measure outcomes and the efficacy of therapeutic interventions.

I’m afraid the authors have not satisfactorily controlled for or analyzed the confounding factors so that plausible conclusions can be reached. The results are striking that mortality and complications were higher for patients treated with open surgery. I have watched the evolution of laparoscopic surgery over the past 25 years, and I am convinced that patients greatly benefit from this technology.

While the laparoscopic approach for treating diverticulitis resonates with my sensibility, the data do not support a clear recommendation. I urge surgeons to focus on this emergency, general-surgery population so that we can do important comparative effectiveness research and address some of these questions.

Dr. Michael F. Rotondo is professor and chairman of surgery at East Carolina University in Greenville, N.C. He had no disclosures. He made these comments as a designated discussant of the report.

Title
Analysis fails to account for possible confounders
Analysis fails to account for possible confounders

PALM BEACH, FLA.– Using laparoscopic surgery for colectomy with primary anastomosis in patients with complicated diverticulitis linked with significantly fewer major complications compared with open surgical management in a review of more than 10,000 patients from a nationwide database.

However, the inherent biases at play when surgeons decide whether to manage a diverticulitis patient by a laparoscopic or open approach make it difficult to draw definitive conclusions from the findings, Dr. Edward E. Cornwell III said at the annual meeting of the Southern Surgical Association.

Dr. Edward E. Cornwell, III

"If a surgeon did an operation laparoscopically, that by itself is an indicator of how sick the patient was. The surgeon selects an open operation for sicker patients, and laparoscopy for the less sick patients," he said in an interview. "Have we accounted for that difference [in the analysis]? That’s an open question," said Dr. Cornwell, professor and chairman of surgery at Howard University in Washington.

"Patients whom the surgeon deem well enough physiologically to sustain colectomy with primary anastomosis deserve strong consideration for the laparoscopic approach because those patients had the greatest difference in complications" compared with open surgery, he said.

The data Dr. Cornwell and his associates reviewed also showed a marked skewing in how surgeons used laparoscopy. Among the 10,085 patients included in the analysis, 7,562 (75%) underwent colectomy with primary anastomosis, and in this subgroup, 5,105 patients (68%) had their surgery done laparoscopically, while the remaining 2,457 (32%) were done with open surgery. In contrast, the 2,523 other patients in the series underwent a colectomy with colostomy, and within this subgroup, 2,286 patients (91%) had open surgery, with only 237 (9%) having laparoscopic surgery.

The overwhelming use of open surgery for the colostomy patients makes sense as it is a more complex operation, Dr. Cornwell said.

He and his associates used data collected during 2005-2009 at 237 U.S. hospitals by the National Surgical Quality Improvement Program of the American College of Surgeons on patients who underwent surgical management of complicated diverticulitis. The average age of the patients was 58 years, and overall 30-day mortality was 2%, while the overall postoperative complication rate during the 30 days following surgery was 23%.

Among the patients who underwent a primary anastomosis, the incidence of major complications during 30 days of follow-up was 13% in the open surgery patients and 6% in the laparoscopy patients, a statistically significant difference. Major complications included surgical site infections, dehiscence, transfusion, respiratory failure, sepsis, myocardial infarction, pulmonary embolism, stroke, renal failure or need for rehospitalization.

In a multivariate analysis that controlled for demographic parameters, body mass index, comorbidities, and functional status, patients who underwent laparoscopy had about half the number of total complications and major complications compared with patients who underwent open surgery – statistically significant differences. The laparoscopically-treated patients also had roughly half the rate of several individual major complications – wound infections, respiratory complications, and sepsis – compared with the open surgery patients, all statistically significant differences.

Thirty-day mortality was about 50% lower with laparoscopy compared with open surgery among patients who underwent a primary anastomosis, but this difference fell short of statistical significance.

The advantage of laparoscopy over open surgery was not nearly so clear among patients who underwent colectomy with colostomy. The data showed no significant difference between laparoscopy and open surgery in the rate of all major complications, although the number of major complications with laparoscopy was about 20% lower. The only individual complications significantly reduced in the laparoscopy group were wound infections, reduced by about 40% in the adjusted analysis, and respiratory complications, cut by about 50% by laparoscopy. The two surgical subgroups showed virtually no difference in 30-day mortality among patients who underwent a colectomy.

The results suggest that because of the broad reduction of major complications with laparoscopy, this approach "should be considered when primary anastomosis is deemed appropriate," Dr. Cornwell concluded.

Dr. Cornwell said that he had no disclosures.

PALM BEACH, FLA.– Using laparoscopic surgery for colectomy with primary anastomosis in patients with complicated diverticulitis linked with significantly fewer major complications compared with open surgical management in a review of more than 10,000 patients from a nationwide database.

However, the inherent biases at play when surgeons decide whether to manage a diverticulitis patient by a laparoscopic or open approach make it difficult to draw definitive conclusions from the findings, Dr. Edward E. Cornwell III said at the annual meeting of the Southern Surgical Association.

Dr. Edward E. Cornwell, III

"If a surgeon did an operation laparoscopically, that by itself is an indicator of how sick the patient was. The surgeon selects an open operation for sicker patients, and laparoscopy for the less sick patients," he said in an interview. "Have we accounted for that difference [in the analysis]? That’s an open question," said Dr. Cornwell, professor and chairman of surgery at Howard University in Washington.

"Patients whom the surgeon deem well enough physiologically to sustain colectomy with primary anastomosis deserve strong consideration for the laparoscopic approach because those patients had the greatest difference in complications" compared with open surgery, he said.

The data Dr. Cornwell and his associates reviewed also showed a marked skewing in how surgeons used laparoscopy. Among the 10,085 patients included in the analysis, 7,562 (75%) underwent colectomy with primary anastomosis, and in this subgroup, 5,105 patients (68%) had their surgery done laparoscopically, while the remaining 2,457 (32%) were done with open surgery. In contrast, the 2,523 other patients in the series underwent a colectomy with colostomy, and within this subgroup, 2,286 patients (91%) had open surgery, with only 237 (9%) having laparoscopic surgery.

The overwhelming use of open surgery for the colostomy patients makes sense as it is a more complex operation, Dr. Cornwell said.

He and his associates used data collected during 2005-2009 at 237 U.S. hospitals by the National Surgical Quality Improvement Program of the American College of Surgeons on patients who underwent surgical management of complicated diverticulitis. The average age of the patients was 58 years, and overall 30-day mortality was 2%, while the overall postoperative complication rate during the 30 days following surgery was 23%.

Among the patients who underwent a primary anastomosis, the incidence of major complications during 30 days of follow-up was 13% in the open surgery patients and 6% in the laparoscopy patients, a statistically significant difference. Major complications included surgical site infections, dehiscence, transfusion, respiratory failure, sepsis, myocardial infarction, pulmonary embolism, stroke, renal failure or need for rehospitalization.

In a multivariate analysis that controlled for demographic parameters, body mass index, comorbidities, and functional status, patients who underwent laparoscopy had about half the number of total complications and major complications compared with patients who underwent open surgery – statistically significant differences. The laparoscopically-treated patients also had roughly half the rate of several individual major complications – wound infections, respiratory complications, and sepsis – compared with the open surgery patients, all statistically significant differences.

Thirty-day mortality was about 50% lower with laparoscopy compared with open surgery among patients who underwent a primary anastomosis, but this difference fell short of statistical significance.

The advantage of laparoscopy over open surgery was not nearly so clear among patients who underwent colectomy with colostomy. The data showed no significant difference between laparoscopy and open surgery in the rate of all major complications, although the number of major complications with laparoscopy was about 20% lower. The only individual complications significantly reduced in the laparoscopy group were wound infections, reduced by about 40% in the adjusted analysis, and respiratory complications, cut by about 50% by laparoscopy. The two surgical subgroups showed virtually no difference in 30-day mortality among patients who underwent a colectomy.

The results suggest that because of the broad reduction of major complications with laparoscopy, this approach "should be considered when primary anastomosis is deemed appropriate," Dr. Cornwell concluded.

Dr. Cornwell said that he had no disclosures.

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Major Finding: Among patients who underwent a primary anastomosis, the incidence of major complications during 30 days of follow-up was 13% in the open surgery patients and 6% in the laparoscopy patients.

Data Source: From 10,085 U.S. patients who had surgery for acute management of complicated diverticulitis during 2005-2009.

Disclosures: Dr. Cornwell said he had no disclosures.

Hysterectomy Trendelenburg position: Less may be more

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Hysterectomy Trendelenburg position: Less may be more

LAS VEGAS – Significantly reducing the degree of Trendelenburg position during robotic-assisted hysterectomy did not increase operative time and cut blood loss in half in a small retrospective analysis.

Surgeons spent an average of 66.5 minutes (range, 38-110 minutes) at the console when patients were placed in a minimum Trendelenburg position, compared with 79 minutes (range, 30-180 minutes) with a steep Trendelenburg position.

The difference in this primary outcome failed to achieve statistical significance (P = .105); however, the use of a minimum Trendelenburg position significantly reduced the average estimated blood loss from 101.3 mL to 50 mL (P = .007), Dr. Kelli Sasada reported at the 41st AAGL Global Congress.

A minimum degree of Trendelenburg position can be as effective as a steep Trendelenburg position in achieving adequate surgical exposure, thereby allowing safe completion of hysterectomy without increasing operative time, she said.

A steep Trendelenburg position, defined as at least 20 degrees in the anesthesia literature, improves the view of the surgical area during pelvic surgery by taking advantage of gravity to retract the bowels. It is common practice to use this approach during robotic-assisted hysterectomy because the patient’s position cannot conveniently be adjusted once the robot is docked, Dr. Sasada explained.

A steep Trendelenburg position, however, is often fraught with complications that can be severe and permanent, such as neural and retinal injuries, the patient moving or sliding off the table, ventilation concerns including airway access for the anesthesia provider, poor cardiopulmonary status, and alopecia, she added.

To explore the minimum degree of Trendelenburg necessary to complete the surgery safely, Dr. Sasada and her associate, Dr. Linda Mihalov, at Virginia Mason Medical Center in Seattle, took advantage of a new iPad app called clinometer HD (by plaincode) among 50 women undergoing da Vinci robotic-assisted benign total laparoscopic hysterectomy with or without bilateral salpingo-oophorectomy. Patients were secured in the dorsal lithotomy position, the abdomen was entered laparoscopically, and a brief survey was conducted to assess the size, position, and accessibility of the pelvic organs. The degree of Trendelenburg was determined by the surgeon and the iPad clinometer HD placed on the bed rail to measure the table tilt. The robot was then docked parallel to the patient’s side, and the surgery completed.

A steep Trendelenburg, defined as 30 degrees, was used in 38 women, and a minimum degree of Trendelenburg averaging 16.6 degrees (range, 13.8-19 degrees) used in 12 women, said Dr. Sasada, now with United Hospital System, St. Catherine’s Medical Center in Pleasant Prairie, Wis.

The average uterine weight was not significantly different between the steep and minimum Trendelenburg groups (215.4 g vs. 173.6 g; P = .21).

Body mass index also was similar at 28.5 kg/m2 vs. 25 kg/m2 (P = .071), with a wide range in both groups, she said.

There was one case of intraoperative bleeding (500 cc) and no postoperative complications in the steep Trendelenburg group, and one case of postoperative urinary retention and no intraoperative complications in the minimum Trendelenburg group.

During a discussion of the study, Dr. Sasada said it’s possible that the lower blood loss with the minimum Trendelenburg position could be due to chance, but that both surgeries were completed with the same four incisions and without bowel prep.

Dr. Sasada currently uses a minimum Trendelenburg position and an iPad when performing robotic-assisted hysterectomy and other pelvic surgeries, but not in all cases, as some OR beds have built-in clinometers. The advantage of the iPad technology is that it offers "ease of use in the OR by anesthesia or nursing staff, and reproducibility between OR beds," she said in an interview.

Dr. Sasada and Dr. Mihalov reported no relevant financial disclosures.

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LAS VEGAS – Significantly reducing the degree of Trendelenburg position during robotic-assisted hysterectomy did not increase operative time and cut blood loss in half in a small retrospective analysis.

Surgeons spent an average of 66.5 minutes (range, 38-110 minutes) at the console when patients were placed in a minimum Trendelenburg position, compared with 79 minutes (range, 30-180 minutes) with a steep Trendelenburg position.

The difference in this primary outcome failed to achieve statistical significance (P = .105); however, the use of a minimum Trendelenburg position significantly reduced the average estimated blood loss from 101.3 mL to 50 mL (P = .007), Dr. Kelli Sasada reported at the 41st AAGL Global Congress.

A minimum degree of Trendelenburg position can be as effective as a steep Trendelenburg position in achieving adequate surgical exposure, thereby allowing safe completion of hysterectomy without increasing operative time, she said.

A steep Trendelenburg position, defined as at least 20 degrees in the anesthesia literature, improves the view of the surgical area during pelvic surgery by taking advantage of gravity to retract the bowels. It is common practice to use this approach during robotic-assisted hysterectomy because the patient’s position cannot conveniently be adjusted once the robot is docked, Dr. Sasada explained.

A steep Trendelenburg position, however, is often fraught with complications that can be severe and permanent, such as neural and retinal injuries, the patient moving or sliding off the table, ventilation concerns including airway access for the anesthesia provider, poor cardiopulmonary status, and alopecia, she added.

To explore the minimum degree of Trendelenburg necessary to complete the surgery safely, Dr. Sasada and her associate, Dr. Linda Mihalov, at Virginia Mason Medical Center in Seattle, took advantage of a new iPad app called clinometer HD (by plaincode) among 50 women undergoing da Vinci robotic-assisted benign total laparoscopic hysterectomy with or without bilateral salpingo-oophorectomy. Patients were secured in the dorsal lithotomy position, the abdomen was entered laparoscopically, and a brief survey was conducted to assess the size, position, and accessibility of the pelvic organs. The degree of Trendelenburg was determined by the surgeon and the iPad clinometer HD placed on the bed rail to measure the table tilt. The robot was then docked parallel to the patient’s side, and the surgery completed.

A steep Trendelenburg, defined as 30 degrees, was used in 38 women, and a minimum degree of Trendelenburg averaging 16.6 degrees (range, 13.8-19 degrees) used in 12 women, said Dr. Sasada, now with United Hospital System, St. Catherine’s Medical Center in Pleasant Prairie, Wis.

The average uterine weight was not significantly different between the steep and minimum Trendelenburg groups (215.4 g vs. 173.6 g; P = .21).

Body mass index also was similar at 28.5 kg/m2 vs. 25 kg/m2 (P = .071), with a wide range in both groups, she said.

There was one case of intraoperative bleeding (500 cc) and no postoperative complications in the steep Trendelenburg group, and one case of postoperative urinary retention and no intraoperative complications in the minimum Trendelenburg group.

During a discussion of the study, Dr. Sasada said it’s possible that the lower blood loss with the minimum Trendelenburg position could be due to chance, but that both surgeries were completed with the same four incisions and without bowel prep.

Dr. Sasada currently uses a minimum Trendelenburg position and an iPad when performing robotic-assisted hysterectomy and other pelvic surgeries, but not in all cases, as some OR beds have built-in clinometers. The advantage of the iPad technology is that it offers "ease of use in the OR by anesthesia or nursing staff, and reproducibility between OR beds," she said in an interview.

Dr. Sasada and Dr. Mihalov reported no relevant financial disclosures.

LAS VEGAS – Significantly reducing the degree of Trendelenburg position during robotic-assisted hysterectomy did not increase operative time and cut blood loss in half in a small retrospective analysis.

Surgeons spent an average of 66.5 minutes (range, 38-110 minutes) at the console when patients were placed in a minimum Trendelenburg position, compared with 79 minutes (range, 30-180 minutes) with a steep Trendelenburg position.

The difference in this primary outcome failed to achieve statistical significance (P = .105); however, the use of a minimum Trendelenburg position significantly reduced the average estimated blood loss from 101.3 mL to 50 mL (P = .007), Dr. Kelli Sasada reported at the 41st AAGL Global Congress.

A minimum degree of Trendelenburg position can be as effective as a steep Trendelenburg position in achieving adequate surgical exposure, thereby allowing safe completion of hysterectomy without increasing operative time, she said.

A steep Trendelenburg position, defined as at least 20 degrees in the anesthesia literature, improves the view of the surgical area during pelvic surgery by taking advantage of gravity to retract the bowels. It is common practice to use this approach during robotic-assisted hysterectomy because the patient’s position cannot conveniently be adjusted once the robot is docked, Dr. Sasada explained.

A steep Trendelenburg position, however, is often fraught with complications that can be severe and permanent, such as neural and retinal injuries, the patient moving or sliding off the table, ventilation concerns including airway access for the anesthesia provider, poor cardiopulmonary status, and alopecia, she added.

To explore the minimum degree of Trendelenburg necessary to complete the surgery safely, Dr. Sasada and her associate, Dr. Linda Mihalov, at Virginia Mason Medical Center in Seattle, took advantage of a new iPad app called clinometer HD (by plaincode) among 50 women undergoing da Vinci robotic-assisted benign total laparoscopic hysterectomy with or without bilateral salpingo-oophorectomy. Patients were secured in the dorsal lithotomy position, the abdomen was entered laparoscopically, and a brief survey was conducted to assess the size, position, and accessibility of the pelvic organs. The degree of Trendelenburg was determined by the surgeon and the iPad clinometer HD placed on the bed rail to measure the table tilt. The robot was then docked parallel to the patient’s side, and the surgery completed.

A steep Trendelenburg, defined as 30 degrees, was used in 38 women, and a minimum degree of Trendelenburg averaging 16.6 degrees (range, 13.8-19 degrees) used in 12 women, said Dr. Sasada, now with United Hospital System, St. Catherine’s Medical Center in Pleasant Prairie, Wis.

The average uterine weight was not significantly different between the steep and minimum Trendelenburg groups (215.4 g vs. 173.6 g; P = .21).

Body mass index also was similar at 28.5 kg/m2 vs. 25 kg/m2 (P = .071), with a wide range in both groups, she said.

There was one case of intraoperative bleeding (500 cc) and no postoperative complications in the steep Trendelenburg group, and one case of postoperative urinary retention and no intraoperative complications in the minimum Trendelenburg group.

During a discussion of the study, Dr. Sasada said it’s possible that the lower blood loss with the minimum Trendelenburg position could be due to chance, but that both surgeries were completed with the same four incisions and without bowel prep.

Dr. Sasada currently uses a minimum Trendelenburg position and an iPad when performing robotic-assisted hysterectomy and other pelvic surgeries, but not in all cases, as some OR beds have built-in clinometers. The advantage of the iPad technology is that it offers "ease of use in the OR by anesthesia or nursing staff, and reproducibility between OR beds," she said in an interview.

Dr. Sasada and Dr. Mihalov reported no relevant financial disclosures.

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Major Finding: Average estimated blood loss was 101.3 mL with the steep Trendelenburg position vs. 50 mL with the minimum Trendelenburg (P = .007).

Data Source: Retrospective chart study of 50 women undergoing robotic-assisted hysterectomy.

Disclosures: Dr. Sasada and Dr. Mihalov reported no relevant financial disclosures.

Ruptured AAA triage to EVAR centers proposed

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Ruptured AAA triage to EVAR centers proposed

PALM BEACH, FLA. – The number of U.S. patients with ruptured abdominal aortic aneurysms who were managed with endovascular aneurysm repair more than doubled during 2005-2009, suggesting that it’s time to develop a national triage system in order to perform emergency endovascular repairs around the clock, according to Dr. John J. Ricotta.

"A strategy that promotes development of EVAR [endovascular aneurysm repair] centers with triage of stable, EVAR-suitable patients may be the best approach," said Dr. Ricotta, a vascular surgeon and chairman of surgery at MedStar Washington (D.C.) Hospital Center.

"Regionalization of EVAR services may be practical, along with a triage system to rapidly diagnose and transfer patients with RAAA [ruptured abdominal aortic aneurysm]," Dr. Ricotta said at the annual meeting of the Southern Surgical Association.

Because the time from the onset of symptoms to the start of successful EVAR repair is often more than 10 hours, stable RAAA patients could be transferred.

"The focus should be on older patients, who are more likely to survive if you do EVAR, and stable patients. Patients who are hemodynamically stable and have good anatomy [for performing EVAR] should go to an EVAR center."

Dr. Ricotta and his associates analyzed data collected from the U.S. Nationwide Inpatient Sample for all patients aged 60 years or older treated for RAAA during 2005-2009. During the 5-year period, a total of 21,218 patients in the sample underwent treatment for RAAA; 60% of the patients underwent open surgical repair, 22% had no operative repair, and 18% had EVAR.

Use of EVAR rose from 10% of RAAA patients in 2005 to 25% in 2009 (see table). Among the subset of patients who had surgical management, EVAR use rose from 13% of patients in 2005 to 32% in 2009.

EVAR was performed primarily at urban teaching hospitals and in patients under 90. Throughout the 5-year period, EVAR use at urban teaching hospitals included 25% of RAAA patients, compared with 12% of these patients managed at urban nonteaching hospitals and 7% of RAAA patients managed at rural hospitals. About 19% of RAAA patients 60-89 years old underwent EVAR, compared with 12% of those aged 90 or older.

EVAR effectively reduced mortality. Throughout the period studied, the rate of in-hospital mortality was 41% in patients managed with open surgery and 28% in those managed with EVAR, a significant difference, Dr. Ricotta said.

Furthermore, EVAR produced a mortality benefit compared with open surgery across the spectrum of patients, regardless of age. For example, among patients who were at least 90 years old, in-hospital mortality following EVAR was 36%, compared with 77% among patients who had open repair. In a multivariate analysis, EVAR was the only demographic or clinical variable associated with a significant reduction in postoperative in-hospital death, cutting mortality by 47%.

Despite EVAR’s success, use of the technique is limited by the anatomic and physiologic presentation of RAAA patients. "With current technology, EVAR is generally thought to be applicable to 30%-50% of RAAA patients," Dr. Ricotta said. "Experienced centers report the use of EVAR for about 50% of RAAA patients."

Dr. Ricotta called for regionalization and a triage and transfer model, because "widespread adoption of EVAR for RAAA is not practical," he said. "It is an expensive and evolving technology that needs a dedicated staff and a high volume of procedures." An EVAR-first program requires ready CT access and suitable imaging facilities in the operating room, a suitable stock of endografts, and an EVAR team that’s available 24/7, he said.

"Patients who are transferred might do better than patients who are not transferred," agreed Dr. Spence M. Taylor, a vascular surgeon and professor of surgery at the University of South Carolina in Greenville. But he added that patient selection may also play a role. "EVAR does better than open surgical repair in patients who can be stabilized and have this intervention compared with patients who can’t."

Dr. Ricotta and Dr. Taylor had no disclosures.

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PALM BEACH, FLA. – The number of U.S. patients with ruptured abdominal aortic aneurysms who were managed with endovascular aneurysm repair more than doubled during 2005-2009, suggesting that it’s time to develop a national triage system in order to perform emergency endovascular repairs around the clock, according to Dr. John J. Ricotta.

"A strategy that promotes development of EVAR [endovascular aneurysm repair] centers with triage of stable, EVAR-suitable patients may be the best approach," said Dr. Ricotta, a vascular surgeon and chairman of surgery at MedStar Washington (D.C.) Hospital Center.

"Regionalization of EVAR services may be practical, along with a triage system to rapidly diagnose and transfer patients with RAAA [ruptured abdominal aortic aneurysm]," Dr. Ricotta said at the annual meeting of the Southern Surgical Association.

Because the time from the onset of symptoms to the start of successful EVAR repair is often more than 10 hours, stable RAAA patients could be transferred.

"The focus should be on older patients, who are more likely to survive if you do EVAR, and stable patients. Patients who are hemodynamically stable and have good anatomy [for performing EVAR] should go to an EVAR center."

Dr. Ricotta and his associates analyzed data collected from the U.S. Nationwide Inpatient Sample for all patients aged 60 years or older treated for RAAA during 2005-2009. During the 5-year period, a total of 21,218 patients in the sample underwent treatment for RAAA; 60% of the patients underwent open surgical repair, 22% had no operative repair, and 18% had EVAR.

Use of EVAR rose from 10% of RAAA patients in 2005 to 25% in 2009 (see table). Among the subset of patients who had surgical management, EVAR use rose from 13% of patients in 2005 to 32% in 2009.

EVAR was performed primarily at urban teaching hospitals and in patients under 90. Throughout the 5-year period, EVAR use at urban teaching hospitals included 25% of RAAA patients, compared with 12% of these patients managed at urban nonteaching hospitals and 7% of RAAA patients managed at rural hospitals. About 19% of RAAA patients 60-89 years old underwent EVAR, compared with 12% of those aged 90 or older.

EVAR effectively reduced mortality. Throughout the period studied, the rate of in-hospital mortality was 41% in patients managed with open surgery and 28% in those managed with EVAR, a significant difference, Dr. Ricotta said.

Furthermore, EVAR produced a mortality benefit compared with open surgery across the spectrum of patients, regardless of age. For example, among patients who were at least 90 years old, in-hospital mortality following EVAR was 36%, compared with 77% among patients who had open repair. In a multivariate analysis, EVAR was the only demographic or clinical variable associated with a significant reduction in postoperative in-hospital death, cutting mortality by 47%.

Despite EVAR’s success, use of the technique is limited by the anatomic and physiologic presentation of RAAA patients. "With current technology, EVAR is generally thought to be applicable to 30%-50% of RAAA patients," Dr. Ricotta said. "Experienced centers report the use of EVAR for about 50% of RAAA patients."

Dr. Ricotta called for regionalization and a triage and transfer model, because "widespread adoption of EVAR for RAAA is not practical," he said. "It is an expensive and evolving technology that needs a dedicated staff and a high volume of procedures." An EVAR-first program requires ready CT access and suitable imaging facilities in the operating room, a suitable stock of endografts, and an EVAR team that’s available 24/7, he said.

"Patients who are transferred might do better than patients who are not transferred," agreed Dr. Spence M. Taylor, a vascular surgeon and professor of surgery at the University of South Carolina in Greenville. But he added that patient selection may also play a role. "EVAR does better than open surgical repair in patients who can be stabilized and have this intervention compared with patients who can’t."

Dr. Ricotta and Dr. Taylor had no disclosures.

PALM BEACH, FLA. – The number of U.S. patients with ruptured abdominal aortic aneurysms who were managed with endovascular aneurysm repair more than doubled during 2005-2009, suggesting that it’s time to develop a national triage system in order to perform emergency endovascular repairs around the clock, according to Dr. John J. Ricotta.

"A strategy that promotes development of EVAR [endovascular aneurysm repair] centers with triage of stable, EVAR-suitable patients may be the best approach," said Dr. Ricotta, a vascular surgeon and chairman of surgery at MedStar Washington (D.C.) Hospital Center.

"Regionalization of EVAR services may be practical, along with a triage system to rapidly diagnose and transfer patients with RAAA [ruptured abdominal aortic aneurysm]," Dr. Ricotta said at the annual meeting of the Southern Surgical Association.

Because the time from the onset of symptoms to the start of successful EVAR repair is often more than 10 hours, stable RAAA patients could be transferred.

"The focus should be on older patients, who are more likely to survive if you do EVAR, and stable patients. Patients who are hemodynamically stable and have good anatomy [for performing EVAR] should go to an EVAR center."

Dr. Ricotta and his associates analyzed data collected from the U.S. Nationwide Inpatient Sample for all patients aged 60 years or older treated for RAAA during 2005-2009. During the 5-year period, a total of 21,218 patients in the sample underwent treatment for RAAA; 60% of the patients underwent open surgical repair, 22% had no operative repair, and 18% had EVAR.

Use of EVAR rose from 10% of RAAA patients in 2005 to 25% in 2009 (see table). Among the subset of patients who had surgical management, EVAR use rose from 13% of patients in 2005 to 32% in 2009.

EVAR was performed primarily at urban teaching hospitals and in patients under 90. Throughout the 5-year period, EVAR use at urban teaching hospitals included 25% of RAAA patients, compared with 12% of these patients managed at urban nonteaching hospitals and 7% of RAAA patients managed at rural hospitals. About 19% of RAAA patients 60-89 years old underwent EVAR, compared with 12% of those aged 90 or older.

EVAR effectively reduced mortality. Throughout the period studied, the rate of in-hospital mortality was 41% in patients managed with open surgery and 28% in those managed with EVAR, a significant difference, Dr. Ricotta said.

Furthermore, EVAR produced a mortality benefit compared with open surgery across the spectrum of patients, regardless of age. For example, among patients who were at least 90 years old, in-hospital mortality following EVAR was 36%, compared with 77% among patients who had open repair. In a multivariate analysis, EVAR was the only demographic or clinical variable associated with a significant reduction in postoperative in-hospital death, cutting mortality by 47%.

Despite EVAR’s success, use of the technique is limited by the anatomic and physiologic presentation of RAAA patients. "With current technology, EVAR is generally thought to be applicable to 30%-50% of RAAA patients," Dr. Ricotta said. "Experienced centers report the use of EVAR for about 50% of RAAA patients."

Dr. Ricotta called for regionalization and a triage and transfer model, because "widespread adoption of EVAR for RAAA is not practical," he said. "It is an expensive and evolving technology that needs a dedicated staff and a high volume of procedures." An EVAR-first program requires ready CT access and suitable imaging facilities in the operating room, a suitable stock of endografts, and an EVAR team that’s available 24/7, he said.

"Patients who are transferred might do better than patients who are not transferred," agreed Dr. Spence M. Taylor, a vascular surgeon and professor of surgery at the University of South Carolina in Greenville. But he added that patient selection may also play a role. "EVAR does better than open surgical repair in patients who can be stabilized and have this intervention compared with patients who can’t."

Dr. Ricotta and Dr. Taylor had no disclosures.

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Ruptured AAA triage to EVAR centers proposed
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ruptured abdominal aortic aneurysms, endovascular aneurysm repair, Dr. John J. Ricotta, EVAR centers, AAA triage
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Major Finding: From 2005 to 2009, the percentage of hospitalized U.S. patients with a ruptured AAA who underwent EVAR grew from 10% to 25%.

Data Source: The data came from an analysis of 21,218 U.S. patients hospitalized for a ruptured abdominal aortic aneurysm during 2005-2009 and included in the Nationwide Inpatient Sample.

Disclosures: Dr. Ricotta and Dr. Taylor had no disclosures.

Antibiotic prophylaxis reduces colorectal surgery readmissions

Evidence-based steps cut surgical site infections
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Antibiotic prophylaxis reduces colorectal surgery readmissions

PALM BEACH, FLA. – Administering a brief oral antibiotic regimen preoperatively to colorectal surgery patients cut the average postoperative hospitalization by more than a day and reduced 30-day readmissions by about 3% compared with no presurgical bowel preparation, a review of more than 8,000 patients found.

The primary driver of these beneficial effects was a reduced rate of surgical site infections, Dr. Mary T. Hawn said at the annual meeting of the Southern Surgical Association.

"Efforts to improve adherence with the use of oral antibiotic preparation may improve the efficiency of care for colorectal surgery," said Dr. Hawn, chief of gastrointestinal surgery at the University of Alabama, Birmingham. "Further research is needed to determine the best protocol for bowel prep prior to colorectal surgery, and to prospectively monitor the rate of Clostridium difficile infection."

The findings by Dr. Hawn’s group also showed that oral antibiotic bowel preparation (OABP) led to a small but statistically significant increase in the rate of hospital readmissions among patients with a principal diagnostic code of colitis caused by C. difficile infection. The OABP patients had a 0.5% readmission rate, compared with a 0.1% rate among patients who received no presurgical bowel preparation.

The value of OABP as shown in this study is particularly important because the use of OABP before colorectal surgery has declined in the United States over the past 20 years, Dr. Hawn added.

Using data collected as part of the VA Surgical Quality Improvement Program, Dr. Hawn and her colleagues analyzed results for 8,180 patients who underwent elective colorectal resection at any of 112 participating VA hospitals during 2005-2009. Patients who had a partial or total colectomy, a rectal resection, or an ostomy were included. Patients were excluded if they had a preoperative stay of more than 2 days, a postoperative stay of more than 30 days, or an American Surgical Association 5 classification, or if they died before hospital discharge.

Most of the patients (83%) underwent surgery for neoplasms; the next most common reason for surgery was diverticulitis, in 6%. OABP was the most common form of presurgical preparation, used on 44% of patients; mechanical preparation only was used on 39%, and no preparation was done in 17%. Ninety percent of the OABP patients also underwent mechanical preparation, while the other 10% had OABP only.

The average postoperative length of stay was 9.1 days among those who received no preparation, 8.6 days for those who got mechanical preparation only, and 7.9 days for those who had OABP – a statistically significant advantage for OABP. In a multivariate regression analysis that controlled for indication, age, and wound class, OABP cut length of stay by an average of 12% compared with no preparation, a statistically significant reduction. In the same analysis, mechanical preparation cut length of stay by only 4% compared with no preparation, also a significant effect.

The hospital readmission rate was 16% with no preparation, 15% with mechanical preparation only, and 13% with OABP. In the multivariate regression analysis with adjustment for procedure, age, and wound class, OABP cut the readmission rate by 19% compared with no preparation, a statistically significant reduction. Mechanical preparation only did not have a statistically significant effect.

Dr. Mary T. Hawn

Further analyses showed that the most common reason for readmission among all patients studied was postoperative infection, in 18%, followed by digestive-system complications, in 10%. C. difficile infection caused 3% of readmissions.

In addition, infections were responsible for readmissions among 6% of patients who underwent no presurgical preparation and in 4% of those who underwent OABP, a statistically significant difference. In contrast, use of OABP produced no statistically significant decline in noninfectious causes of readmission. This rate ran 10% among patients with no preparation, and 9% in patients who underwent OABP.

Dr. Hawn said that she had no disclosures.

Body

Surgical site infections (SSIs) remain a vexing problem despite the significant efforts by hospitals to increase compliance with measures of the Surgical Care Improvement Project. These efforts have so far failed to translate into improved outcomes. We need to identify additional processes that can be changed to improve surgical outcomes.

    



Elizabeth C. Wick

At Johns Hopkins, we addressed SSIs by implementing the Comprehensive Unit-Based Safety Program for patients undergoing colorectal surgery. Interventions included standardization of skin preparation, administration of preoperative chlorhexidine showers, selective elimination of mechanical bowel preparation, warming of patients in the preanesthesia area, adoption of enhanced sterile techniques for skin and fascial closure, and addressing previously unrecognized lapses in antibiotic prophylaxis. The program was modeled on ICU processes designed to prevent central line bloodstream infections.

Our program improved the operating room culture by engaging and empowering front-line staff to address deficits and improve processes. A recent review of the rate of SSIs during the 12 months prior to and the 12 months after implementation of this program found that infection rates fell from 27% before implementation to 18% afterward – a 33% relative decrease (J. Am. Coll. Surg. 2012;215:193-200).

We are expanding this program to colon surgery programs at more than 100 U.S. hospitals. Hospitals want to institute new processes proven to improve patient outcomes. The report by Dr. Hawn and her associates is an important step toward identifying a new approach that might further reduce SSIs.

Dr. Elizabeth C. Wick is a colorectal surgeon at Johns Hopkins Hospital in Baltimore. She had no disclosures. She made these comments as a designated discussant for Dr. Hawn’s report.

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Surgical site infections (SSIs) remain a vexing problem despite the significant efforts by hospitals to increase compliance with measures of the Surgical Care Improvement Project. These efforts have so far failed to translate into improved outcomes. We need to identify additional processes that can be changed to improve surgical outcomes.

    



Elizabeth C. Wick

At Johns Hopkins, we addressed SSIs by implementing the Comprehensive Unit-Based Safety Program for patients undergoing colorectal surgery. Interventions included standardization of skin preparation, administration of preoperative chlorhexidine showers, selective elimination of mechanical bowel preparation, warming of patients in the preanesthesia area, adoption of enhanced sterile techniques for skin and fascial closure, and addressing previously unrecognized lapses in antibiotic prophylaxis. The program was modeled on ICU processes designed to prevent central line bloodstream infections.

Our program improved the operating room culture by engaging and empowering front-line staff to address deficits and improve processes. A recent review of the rate of SSIs during the 12 months prior to and the 12 months after implementation of this program found that infection rates fell from 27% before implementation to 18% afterward – a 33% relative decrease (J. Am. Coll. Surg. 2012;215:193-200).

We are expanding this program to colon surgery programs at more than 100 U.S. hospitals. Hospitals want to institute new processes proven to improve patient outcomes. The report by Dr. Hawn and her associates is an important step toward identifying a new approach that might further reduce SSIs.

Dr. Elizabeth C. Wick is a colorectal surgeon at Johns Hopkins Hospital in Baltimore. She had no disclosures. She made these comments as a designated discussant for Dr. Hawn’s report.

Body

Surgical site infections (SSIs) remain a vexing problem despite the significant efforts by hospitals to increase compliance with measures of the Surgical Care Improvement Project. These efforts have so far failed to translate into improved outcomes. We need to identify additional processes that can be changed to improve surgical outcomes.

    



Elizabeth C. Wick

At Johns Hopkins, we addressed SSIs by implementing the Comprehensive Unit-Based Safety Program for patients undergoing colorectal surgery. Interventions included standardization of skin preparation, administration of preoperative chlorhexidine showers, selective elimination of mechanical bowel preparation, warming of patients in the preanesthesia area, adoption of enhanced sterile techniques for skin and fascial closure, and addressing previously unrecognized lapses in antibiotic prophylaxis. The program was modeled on ICU processes designed to prevent central line bloodstream infections.

Our program improved the operating room culture by engaging and empowering front-line staff to address deficits and improve processes. A recent review of the rate of SSIs during the 12 months prior to and the 12 months after implementation of this program found that infection rates fell from 27% before implementation to 18% afterward – a 33% relative decrease (J. Am. Coll. Surg. 2012;215:193-200).

We are expanding this program to colon surgery programs at more than 100 U.S. hospitals. Hospitals want to institute new processes proven to improve patient outcomes. The report by Dr. Hawn and her associates is an important step toward identifying a new approach that might further reduce SSIs.

Dr. Elizabeth C. Wick is a colorectal surgeon at Johns Hopkins Hospital in Baltimore. She had no disclosures. She made these comments as a designated discussant for Dr. Hawn’s report.

Title
Evidence-based steps cut surgical site infections
Evidence-based steps cut surgical site infections

PALM BEACH, FLA. – Administering a brief oral antibiotic regimen preoperatively to colorectal surgery patients cut the average postoperative hospitalization by more than a day and reduced 30-day readmissions by about 3% compared with no presurgical bowel preparation, a review of more than 8,000 patients found.

The primary driver of these beneficial effects was a reduced rate of surgical site infections, Dr. Mary T. Hawn said at the annual meeting of the Southern Surgical Association.

"Efforts to improve adherence with the use of oral antibiotic preparation may improve the efficiency of care for colorectal surgery," said Dr. Hawn, chief of gastrointestinal surgery at the University of Alabama, Birmingham. "Further research is needed to determine the best protocol for bowel prep prior to colorectal surgery, and to prospectively monitor the rate of Clostridium difficile infection."

The findings by Dr. Hawn’s group also showed that oral antibiotic bowel preparation (OABP) led to a small but statistically significant increase in the rate of hospital readmissions among patients with a principal diagnostic code of colitis caused by C. difficile infection. The OABP patients had a 0.5% readmission rate, compared with a 0.1% rate among patients who received no presurgical bowel preparation.

The value of OABP as shown in this study is particularly important because the use of OABP before colorectal surgery has declined in the United States over the past 20 years, Dr. Hawn added.

Using data collected as part of the VA Surgical Quality Improvement Program, Dr. Hawn and her colleagues analyzed results for 8,180 patients who underwent elective colorectal resection at any of 112 participating VA hospitals during 2005-2009. Patients who had a partial or total colectomy, a rectal resection, or an ostomy were included. Patients were excluded if they had a preoperative stay of more than 2 days, a postoperative stay of more than 30 days, or an American Surgical Association 5 classification, or if they died before hospital discharge.

Most of the patients (83%) underwent surgery for neoplasms; the next most common reason for surgery was diverticulitis, in 6%. OABP was the most common form of presurgical preparation, used on 44% of patients; mechanical preparation only was used on 39%, and no preparation was done in 17%. Ninety percent of the OABP patients also underwent mechanical preparation, while the other 10% had OABP only.

The average postoperative length of stay was 9.1 days among those who received no preparation, 8.6 days for those who got mechanical preparation only, and 7.9 days for those who had OABP – a statistically significant advantage for OABP. In a multivariate regression analysis that controlled for indication, age, and wound class, OABP cut length of stay by an average of 12% compared with no preparation, a statistically significant reduction. In the same analysis, mechanical preparation cut length of stay by only 4% compared with no preparation, also a significant effect.

The hospital readmission rate was 16% with no preparation, 15% with mechanical preparation only, and 13% with OABP. In the multivariate regression analysis with adjustment for procedure, age, and wound class, OABP cut the readmission rate by 19% compared with no preparation, a statistically significant reduction. Mechanical preparation only did not have a statistically significant effect.

Dr. Mary T. Hawn

Further analyses showed that the most common reason for readmission among all patients studied was postoperative infection, in 18%, followed by digestive-system complications, in 10%. C. difficile infection caused 3% of readmissions.

In addition, infections were responsible for readmissions among 6% of patients who underwent no presurgical preparation and in 4% of those who underwent OABP, a statistically significant difference. In contrast, use of OABP produced no statistically significant decline in noninfectious causes of readmission. This rate ran 10% among patients with no preparation, and 9% in patients who underwent OABP.

Dr. Hawn said that she had no disclosures.

PALM BEACH, FLA. – Administering a brief oral antibiotic regimen preoperatively to colorectal surgery patients cut the average postoperative hospitalization by more than a day and reduced 30-day readmissions by about 3% compared with no presurgical bowel preparation, a review of more than 8,000 patients found.

The primary driver of these beneficial effects was a reduced rate of surgical site infections, Dr. Mary T. Hawn said at the annual meeting of the Southern Surgical Association.

"Efforts to improve adherence with the use of oral antibiotic preparation may improve the efficiency of care for colorectal surgery," said Dr. Hawn, chief of gastrointestinal surgery at the University of Alabama, Birmingham. "Further research is needed to determine the best protocol for bowel prep prior to colorectal surgery, and to prospectively monitor the rate of Clostridium difficile infection."

The findings by Dr. Hawn’s group also showed that oral antibiotic bowel preparation (OABP) led to a small but statistically significant increase in the rate of hospital readmissions among patients with a principal diagnostic code of colitis caused by C. difficile infection. The OABP patients had a 0.5% readmission rate, compared with a 0.1% rate among patients who received no presurgical bowel preparation.

The value of OABP as shown in this study is particularly important because the use of OABP before colorectal surgery has declined in the United States over the past 20 years, Dr. Hawn added.

Using data collected as part of the VA Surgical Quality Improvement Program, Dr. Hawn and her colleagues analyzed results for 8,180 patients who underwent elective colorectal resection at any of 112 participating VA hospitals during 2005-2009. Patients who had a partial or total colectomy, a rectal resection, or an ostomy were included. Patients were excluded if they had a preoperative stay of more than 2 days, a postoperative stay of more than 30 days, or an American Surgical Association 5 classification, or if they died before hospital discharge.

Most of the patients (83%) underwent surgery for neoplasms; the next most common reason for surgery was diverticulitis, in 6%. OABP was the most common form of presurgical preparation, used on 44% of patients; mechanical preparation only was used on 39%, and no preparation was done in 17%. Ninety percent of the OABP patients also underwent mechanical preparation, while the other 10% had OABP only.

The average postoperative length of stay was 9.1 days among those who received no preparation, 8.6 days for those who got mechanical preparation only, and 7.9 days for those who had OABP – a statistically significant advantage for OABP. In a multivariate regression analysis that controlled for indication, age, and wound class, OABP cut length of stay by an average of 12% compared with no preparation, a statistically significant reduction. In the same analysis, mechanical preparation cut length of stay by only 4% compared with no preparation, also a significant effect.

The hospital readmission rate was 16% with no preparation, 15% with mechanical preparation only, and 13% with OABP. In the multivariate regression analysis with adjustment for procedure, age, and wound class, OABP cut the readmission rate by 19% compared with no preparation, a statistically significant reduction. Mechanical preparation only did not have a statistically significant effect.

Dr. Mary T. Hawn

Further analyses showed that the most common reason for readmission among all patients studied was postoperative infection, in 18%, followed by digestive-system complications, in 10%. C. difficile infection caused 3% of readmissions.

In addition, infections were responsible for readmissions among 6% of patients who underwent no presurgical preparation and in 4% of those who underwent OABP, a statistically significant difference. In contrast, use of OABP produced no statistically significant decline in noninfectious causes of readmission. This rate ran 10% among patients with no preparation, and 9% in patients who underwent OABP.

Dr. Hawn said that she had no disclosures.

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Antibiotic prophylaxis reduces colorectal surgery readmissions
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AT THE ANNUAL MEETING OF THE SOUTHERN SURGICAL ASSOCIATION

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Major Finding: Oral antibiotic preparation before colorectal surgery cut hospital readmissions by 19% compared with no preparation.

Data Source: A review of 8,180 U.S. patients who underwent colorectal surgery during 2005-2009 at 112 VA hospitals.

Disclosures: Dr. Hawn said that she had no disclosures.

Avatrombopag reduces preprocedure platelet needs in chronic liver disease

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Avatrombopag reduces preprocedure platelet needs in chronic liver disease

BOSTON – Avatrombopag, an investigational thrombopoietin receptor agonist, may reduce procedure-related bleeding risk in patients with chronic liver disease and thrombocytopenia, results of a phase II trial suggest.

Patients randomized to receive avatrambopag (E5501) before invasive surgical or diagnostic procedures had significantly more platelet count responses and required significantly fewer platelet transfusions than did patients randomized to placebo, Dr. Norah Terrault said at the annual meeting of the American Association for the Study of Liver Diseases.

"It was a well-tolerated drug with no dose-limiting adverse events," Dr. Terrault said, although she noted that one patient had a nonfatal episode of portal-vein thrombosis that may have been related to the drug.

Avatrombopag has been shown to mimic the effects of thrombopoietin both in vitro and in vivo, and in a phase II study it was shown to increase platelet counts in patients with chronic immune thrombocytopenia.

Dr. Terrault, associate professor of medicine in the division of gastroenterology at the University of California, San Francisco, and her colleagues tested the efficacy of short-course avatrombopag in 130 patients with chronic liver disease and thrombocytopenia prior to a planned invasive procedure. The patients were all adults with cirrhosis from viral hepatitis, nonalcoholic steatohepatitis, or alcoholic liver disease.

The trial, labeled E5501-G000-202, enrolled patients into two cohorts. In cohort A, 67 patients were randomly assigned to receive either placebo or a loading dose of a first-generation formulation of avatrombopag 100 mg on day 1, followed by a maintenance dose on days 2-7 of either 20, 40, or 80 mg daily.

In cohort B, 63 patients were randomized either to placebo or to a second-generation formulation of avatrombopag at 80 mg on day 1, followed by either 10 mg daily for days 2-7 or 20 mg/day for days 2-4 and placebo on days 5, 6, and 7.

Patients in both cohorts were scheduled for procedures 1-4 days after the end of drug dosing.

The primary end point was a platelet count response – defined as a platelet count increase from baseline of at least 20 × 109/L and at least one count of greater than 50 × 109/L during days 4-8 from the start of treatment. In an intention-to-treat analysis, the proportion of patients achieving the primary end point was significantly higher in each cohort compared with controls.

In cohort A, the respective responses in the 20- and 80-mg groups were seen in 7 of 18 patients on the 20-mg dose (38.9%) and in 13 of 17 on the 80-mg dose (76.5%), compared with 1 of 16 (6.3%) controls (P less than .05 for both comparisons). There was no significant difference between patients given a placebo vs. a 40-mg dose, however.

In cohort B, 9 of 21 patients on the 10-mg dose (42.9%) had a platelet count response, as did 11 of 21 (52.4%) in the 20-mg group, compared with 2 of 21 on placebo (9.5%; P less than .05 for both comparisons).

The investigators also performed an exploratory analysis looking at platelet transfusion requirements for 58 of the patients in cohort B and found that 7 of 20 (35%) controls needed preprocedure platelets, compared with 1 of 19 (5.3%) each in the 10- and 20-mg avatrombopag groups (P less than .05).

In the combined cohorts, 78 of 93 (83.9%) patients assigned to the drug had treatment-emergent adverse events, compared with 28 of 37 (75.7%) assigned to placebo. There were 15 grade-3 or -4 adverse events among avatrombopag patients (16.1%), compared with 5 among controls (13.5%).

There were three severe treatment-related events, all in patients who received the active drug, and 16 serious treatment-related events among those taking avatrombopag, compared with four on placebo (17.2% vs. 10.8%).

One patient – a 55-year-old with a history of cardiovascular disease, Child-Pugh class C cirrhosis, and a MELD (Model for End-Stage Liver Disease) score of 19 – died. The death was attributed to acute respiratory failure, cardiopulmonary arrest, and metabolic acidosis.

A 61-year-old man with Child-Pugh class C disease and a MELD score of 19 but no hepatocellular carcinoma had weight gain on study day 34, which was shown on Doppler ultrasound to be portal-vein thrombus. His peak platelet count was 199 × 109/L on day 17. He was successfully treated with embolization and anticoagulation therapy.

Investigators are currently planning phase III trials with avatrombopag, Dr. Terrault said.

The study was funded by Eisai, maker of avatrombopag. Dr. Terrault receives grant and research support from the company and serves in an advisory capacity.

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BOSTON – Avatrombopag, an investigational thrombopoietin receptor agonist, may reduce procedure-related bleeding risk in patients with chronic liver disease and thrombocytopenia, results of a phase II trial suggest.

Patients randomized to receive avatrambopag (E5501) before invasive surgical or diagnostic procedures had significantly more platelet count responses and required significantly fewer platelet transfusions than did patients randomized to placebo, Dr. Norah Terrault said at the annual meeting of the American Association for the Study of Liver Diseases.

"It was a well-tolerated drug with no dose-limiting adverse events," Dr. Terrault said, although she noted that one patient had a nonfatal episode of portal-vein thrombosis that may have been related to the drug.

Avatrombopag has been shown to mimic the effects of thrombopoietin both in vitro and in vivo, and in a phase II study it was shown to increase platelet counts in patients with chronic immune thrombocytopenia.

Dr. Terrault, associate professor of medicine in the division of gastroenterology at the University of California, San Francisco, and her colleagues tested the efficacy of short-course avatrombopag in 130 patients with chronic liver disease and thrombocytopenia prior to a planned invasive procedure. The patients were all adults with cirrhosis from viral hepatitis, nonalcoholic steatohepatitis, or alcoholic liver disease.

The trial, labeled E5501-G000-202, enrolled patients into two cohorts. In cohort A, 67 patients were randomly assigned to receive either placebo or a loading dose of a first-generation formulation of avatrombopag 100 mg on day 1, followed by a maintenance dose on days 2-7 of either 20, 40, or 80 mg daily.

In cohort B, 63 patients were randomized either to placebo or to a second-generation formulation of avatrombopag at 80 mg on day 1, followed by either 10 mg daily for days 2-7 or 20 mg/day for days 2-4 and placebo on days 5, 6, and 7.

Patients in both cohorts were scheduled for procedures 1-4 days after the end of drug dosing.

The primary end point was a platelet count response – defined as a platelet count increase from baseline of at least 20 × 109/L and at least one count of greater than 50 × 109/L during days 4-8 from the start of treatment. In an intention-to-treat analysis, the proportion of patients achieving the primary end point was significantly higher in each cohort compared with controls.

In cohort A, the respective responses in the 20- and 80-mg groups were seen in 7 of 18 patients on the 20-mg dose (38.9%) and in 13 of 17 on the 80-mg dose (76.5%), compared with 1 of 16 (6.3%) controls (P less than .05 for both comparisons). There was no significant difference between patients given a placebo vs. a 40-mg dose, however.

In cohort B, 9 of 21 patients on the 10-mg dose (42.9%) had a platelet count response, as did 11 of 21 (52.4%) in the 20-mg group, compared with 2 of 21 on placebo (9.5%; P less than .05 for both comparisons).

The investigators also performed an exploratory analysis looking at platelet transfusion requirements for 58 of the patients in cohort B and found that 7 of 20 (35%) controls needed preprocedure platelets, compared with 1 of 19 (5.3%) each in the 10- and 20-mg avatrombopag groups (P less than .05).

In the combined cohorts, 78 of 93 (83.9%) patients assigned to the drug had treatment-emergent adverse events, compared with 28 of 37 (75.7%) assigned to placebo. There were 15 grade-3 or -4 adverse events among avatrombopag patients (16.1%), compared with 5 among controls (13.5%).

There were three severe treatment-related events, all in patients who received the active drug, and 16 serious treatment-related events among those taking avatrombopag, compared with four on placebo (17.2% vs. 10.8%).

One patient – a 55-year-old with a history of cardiovascular disease, Child-Pugh class C cirrhosis, and a MELD (Model for End-Stage Liver Disease) score of 19 – died. The death was attributed to acute respiratory failure, cardiopulmonary arrest, and metabolic acidosis.

A 61-year-old man with Child-Pugh class C disease and a MELD score of 19 but no hepatocellular carcinoma had weight gain on study day 34, which was shown on Doppler ultrasound to be portal-vein thrombus. His peak platelet count was 199 × 109/L on day 17. He was successfully treated with embolization and anticoagulation therapy.

Investigators are currently planning phase III trials with avatrombopag, Dr. Terrault said.

The study was funded by Eisai, maker of avatrombopag. Dr. Terrault receives grant and research support from the company and serves in an advisory capacity.

BOSTON – Avatrombopag, an investigational thrombopoietin receptor agonist, may reduce procedure-related bleeding risk in patients with chronic liver disease and thrombocytopenia, results of a phase II trial suggest.

Patients randomized to receive avatrambopag (E5501) before invasive surgical or diagnostic procedures had significantly more platelet count responses and required significantly fewer platelet transfusions than did patients randomized to placebo, Dr. Norah Terrault said at the annual meeting of the American Association for the Study of Liver Diseases.

"It was a well-tolerated drug with no dose-limiting adverse events," Dr. Terrault said, although she noted that one patient had a nonfatal episode of portal-vein thrombosis that may have been related to the drug.

Avatrombopag has been shown to mimic the effects of thrombopoietin both in vitro and in vivo, and in a phase II study it was shown to increase platelet counts in patients with chronic immune thrombocytopenia.

Dr. Terrault, associate professor of medicine in the division of gastroenterology at the University of California, San Francisco, and her colleagues tested the efficacy of short-course avatrombopag in 130 patients with chronic liver disease and thrombocytopenia prior to a planned invasive procedure. The patients were all adults with cirrhosis from viral hepatitis, nonalcoholic steatohepatitis, or alcoholic liver disease.

The trial, labeled E5501-G000-202, enrolled patients into two cohorts. In cohort A, 67 patients were randomly assigned to receive either placebo or a loading dose of a first-generation formulation of avatrombopag 100 mg on day 1, followed by a maintenance dose on days 2-7 of either 20, 40, or 80 mg daily.

In cohort B, 63 patients were randomized either to placebo or to a second-generation formulation of avatrombopag at 80 mg on day 1, followed by either 10 mg daily for days 2-7 or 20 mg/day for days 2-4 and placebo on days 5, 6, and 7.

Patients in both cohorts were scheduled for procedures 1-4 days after the end of drug dosing.

The primary end point was a platelet count response – defined as a platelet count increase from baseline of at least 20 × 109/L and at least one count of greater than 50 × 109/L during days 4-8 from the start of treatment. In an intention-to-treat analysis, the proportion of patients achieving the primary end point was significantly higher in each cohort compared with controls.

In cohort A, the respective responses in the 20- and 80-mg groups were seen in 7 of 18 patients on the 20-mg dose (38.9%) and in 13 of 17 on the 80-mg dose (76.5%), compared with 1 of 16 (6.3%) controls (P less than .05 for both comparisons). There was no significant difference between patients given a placebo vs. a 40-mg dose, however.

In cohort B, 9 of 21 patients on the 10-mg dose (42.9%) had a platelet count response, as did 11 of 21 (52.4%) in the 20-mg group, compared with 2 of 21 on placebo (9.5%; P less than .05 for both comparisons).

The investigators also performed an exploratory analysis looking at platelet transfusion requirements for 58 of the patients in cohort B and found that 7 of 20 (35%) controls needed preprocedure platelets, compared with 1 of 19 (5.3%) each in the 10- and 20-mg avatrombopag groups (P less than .05).

In the combined cohorts, 78 of 93 (83.9%) patients assigned to the drug had treatment-emergent adverse events, compared with 28 of 37 (75.7%) assigned to placebo. There were 15 grade-3 or -4 adverse events among avatrombopag patients (16.1%), compared with 5 among controls (13.5%).

There were three severe treatment-related events, all in patients who received the active drug, and 16 serious treatment-related events among those taking avatrombopag, compared with four on placebo (17.2% vs. 10.8%).

One patient – a 55-year-old with a history of cardiovascular disease, Child-Pugh class C cirrhosis, and a MELD (Model for End-Stage Liver Disease) score of 19 – died. The death was attributed to acute respiratory failure, cardiopulmonary arrest, and metabolic acidosis.

A 61-year-old man with Child-Pugh class C disease and a MELD score of 19 but no hepatocellular carcinoma had weight gain on study day 34, which was shown on Doppler ultrasound to be portal-vein thrombus. His peak platelet count was 199 × 109/L on day 17. He was successfully treated with embolization and anticoagulation therapy.

Investigators are currently planning phase III trials with avatrombopag, Dr. Terrault said.

The study was funded by Eisai, maker of avatrombopag. Dr. Terrault receives grant and research support from the company and serves in an advisory capacity.

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Avatrombopag reduces preprocedure platelet needs in chronic liver disease
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Avatrombopag, thrombopoietin receptor, bleeding, chronic liver disease, thrombocytopenia, liver disease, Dr. Norah Terraul, American Association for the Study of Liver Diseases, EE501
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AT THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES

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Major Finding: In a study cohort with a second-generation formulation of avatrombopag, 9 of 21 patients on a 10-mg daily dose (42.9%) had a platelet count response, as did 11 of 21 (52.4%) in the 20-mg group, compared with 2 of 21 on placebo (9.5%; P less than .05 for both comparisons).

Data Source: Randomized, double-blind, placebo-controlled phase II trial.

Disclosures: The study was funded by Eisai, maker of avatrombopag. Dr. Terrault receives grant and research support from the company and serves in an advisory capacity.

Bariatric surgery cut vascular events in diabetes

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PALM BEACH, FLA. – Add another notch to the evidence base for bariatric surgery as effective treatment for type 2 diabetes in obese patients.

Patients with type 2 diabetes who underwent any type of bariatric surgery had a 61%-78% relative risk reduction in their rate of macrovascular, microvascular, or vascular events during an average 20-month follow-up in a review of more than 15,000 cases in South Carolina.

Dr. John D. Scott

"We are trying to get primary care physicians to spread the word [to patients] that bariatric surgery has come a long way over the past 30 or 40 years; the risk-to-reward ratio is much more beneficial to patients," Dr. John D. Scott said at the annual meeting of the Southern Surgical Association.

The new finding "adds to the extensive list of papers that show bariatric surgery mitigates the long-term effects of type 2 diabetes," Dr. Scott added in an interview. "Some front-line medical providers still see bariatric surgery as a procedure of last resort, but findings like ours show that a discussion [with patients on whether they should consider bariatric surgery] should happen a lot sooner."

Dr. Scott, a surgeon at University Medical Center in Greenville, S.C., recommended that patients with a body mass index of at least 35 kg/m2 and two or more comorbidities be told that they have the option of undergoing bariatric surgery and reducing their risk.

"We have an epidemic [of obesity and type 2 diabetes], and for the first time since tuberculosis, this is an epidemic where surgery has a real opportunity to positively intervene," commented Dr. Josef E. Fischer, a professor of surgery at Harvard Medical School in Boston.

The study used hospital billing data collected by the South Carolina Office of Research and Statistics as well as state vital records data for 1995-2009. The analysis included 2,580 obese patients who underwent any type of bariatric surgery and 13,371 obese patients who did not have surgery. The researchers extracted the data from records of nearly 34,000 obese patients, but excluded patients with type 1 diabetes, patients with incomplete data, and patients with advanced cardiovascular or microvascular disease at the time of their surgery or entry into the state records during this period.

During a median follow-up of about 20 months, the rate of new-onset macro- or microvascular events was 2% in the bariatric surgery patients and 11% in the patients who did not undergo surgery. The rate of an incident vascular disease event was 2% in the patients who had surgery and 13% in those who did not. Macrovascular events included myocardial infarction, stroke, and all-cause death. Microvascular events included blindness in at least one eye, laser eye surgery, nontraumatic amputation, or placement of access for dialysis. Other vascular events included new-onset heart failure or angina, or revascularization of a coronary, carotid, or peripheral artery.

In a multivariate-adjusted analysis, patients who underwent bariatric surgery had a 61% reduction in macrovascular events, a 78% reduction in microvascular events, a 75% reduction in vascular events, and a 64% reduction in combined macro- and microvascular events, compared with patients who did not have this surgery – all statistically significant differences, reported Dr. Spence M. Taylor, a coinvestigator with Dr. Scott on the study. A propensity-score matched analysis that compared the bariatric surgery patients and matched nonsurgical patients showed very similar reductions in all three event categories.

"Bariatric surgery has a substantial and lasting mitigating association on major complications associated with type 2 diabetes in the obese population," concluded Dr. Taylor, chairman of surgery at the University Medical Center in Greenville.

Dr. Scott, Dr. Fischer, and Dr. Taylor had no relevant disclosures.

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PALM BEACH, FLA. – Add another notch to the evidence base for bariatric surgery as effective treatment for type 2 diabetes in obese patients.

Patients with type 2 diabetes who underwent any type of bariatric surgery had a 61%-78% relative risk reduction in their rate of macrovascular, microvascular, or vascular events during an average 20-month follow-up in a review of more than 15,000 cases in South Carolina.

Dr. John D. Scott

"We are trying to get primary care physicians to spread the word [to patients] that bariatric surgery has come a long way over the past 30 or 40 years; the risk-to-reward ratio is much more beneficial to patients," Dr. John D. Scott said at the annual meeting of the Southern Surgical Association.

The new finding "adds to the extensive list of papers that show bariatric surgery mitigates the long-term effects of type 2 diabetes," Dr. Scott added in an interview. "Some front-line medical providers still see bariatric surgery as a procedure of last resort, but findings like ours show that a discussion [with patients on whether they should consider bariatric surgery] should happen a lot sooner."

Dr. Scott, a surgeon at University Medical Center in Greenville, S.C., recommended that patients with a body mass index of at least 35 kg/m2 and two or more comorbidities be told that they have the option of undergoing bariatric surgery and reducing their risk.

"We have an epidemic [of obesity and type 2 diabetes], and for the first time since tuberculosis, this is an epidemic where surgery has a real opportunity to positively intervene," commented Dr. Josef E. Fischer, a professor of surgery at Harvard Medical School in Boston.

The study used hospital billing data collected by the South Carolina Office of Research and Statistics as well as state vital records data for 1995-2009. The analysis included 2,580 obese patients who underwent any type of bariatric surgery and 13,371 obese patients who did not have surgery. The researchers extracted the data from records of nearly 34,000 obese patients, but excluded patients with type 1 diabetes, patients with incomplete data, and patients with advanced cardiovascular or microvascular disease at the time of their surgery or entry into the state records during this period.

During a median follow-up of about 20 months, the rate of new-onset macro- or microvascular events was 2% in the bariatric surgery patients and 11% in the patients who did not undergo surgery. The rate of an incident vascular disease event was 2% in the patients who had surgery and 13% in those who did not. Macrovascular events included myocardial infarction, stroke, and all-cause death. Microvascular events included blindness in at least one eye, laser eye surgery, nontraumatic amputation, or placement of access for dialysis. Other vascular events included new-onset heart failure or angina, or revascularization of a coronary, carotid, or peripheral artery.

In a multivariate-adjusted analysis, patients who underwent bariatric surgery had a 61% reduction in macrovascular events, a 78% reduction in microvascular events, a 75% reduction in vascular events, and a 64% reduction in combined macro- and microvascular events, compared with patients who did not have this surgery – all statistically significant differences, reported Dr. Spence M. Taylor, a coinvestigator with Dr. Scott on the study. A propensity-score matched analysis that compared the bariatric surgery patients and matched nonsurgical patients showed very similar reductions in all three event categories.

"Bariatric surgery has a substantial and lasting mitigating association on major complications associated with type 2 diabetes in the obese population," concluded Dr. Taylor, chairman of surgery at the University Medical Center in Greenville.

Dr. Scott, Dr. Fischer, and Dr. Taylor had no relevant disclosures.

PALM BEACH, FLA. – Add another notch to the evidence base for bariatric surgery as effective treatment for type 2 diabetes in obese patients.

Patients with type 2 diabetes who underwent any type of bariatric surgery had a 61%-78% relative risk reduction in their rate of macrovascular, microvascular, or vascular events during an average 20-month follow-up in a review of more than 15,000 cases in South Carolina.

Dr. John D. Scott

"We are trying to get primary care physicians to spread the word [to patients] that bariatric surgery has come a long way over the past 30 or 40 years; the risk-to-reward ratio is much more beneficial to patients," Dr. John D. Scott said at the annual meeting of the Southern Surgical Association.

The new finding "adds to the extensive list of papers that show bariatric surgery mitigates the long-term effects of type 2 diabetes," Dr. Scott added in an interview. "Some front-line medical providers still see bariatric surgery as a procedure of last resort, but findings like ours show that a discussion [with patients on whether they should consider bariatric surgery] should happen a lot sooner."

Dr. Scott, a surgeon at University Medical Center in Greenville, S.C., recommended that patients with a body mass index of at least 35 kg/m2 and two or more comorbidities be told that they have the option of undergoing bariatric surgery and reducing their risk.

"We have an epidemic [of obesity and type 2 diabetes], and for the first time since tuberculosis, this is an epidemic where surgery has a real opportunity to positively intervene," commented Dr. Josef E. Fischer, a professor of surgery at Harvard Medical School in Boston.

The study used hospital billing data collected by the South Carolina Office of Research and Statistics as well as state vital records data for 1995-2009. The analysis included 2,580 obese patients who underwent any type of bariatric surgery and 13,371 obese patients who did not have surgery. The researchers extracted the data from records of nearly 34,000 obese patients, but excluded patients with type 1 diabetes, patients with incomplete data, and patients with advanced cardiovascular or microvascular disease at the time of their surgery or entry into the state records during this period.

During a median follow-up of about 20 months, the rate of new-onset macro- or microvascular events was 2% in the bariatric surgery patients and 11% in the patients who did not undergo surgery. The rate of an incident vascular disease event was 2% in the patients who had surgery and 13% in those who did not. Macrovascular events included myocardial infarction, stroke, and all-cause death. Microvascular events included blindness in at least one eye, laser eye surgery, nontraumatic amputation, or placement of access for dialysis. Other vascular events included new-onset heart failure or angina, or revascularization of a coronary, carotid, or peripheral artery.

In a multivariate-adjusted analysis, patients who underwent bariatric surgery had a 61% reduction in macrovascular events, a 78% reduction in microvascular events, a 75% reduction in vascular events, and a 64% reduction in combined macro- and microvascular events, compared with patients who did not have this surgery – all statistically significant differences, reported Dr. Spence M. Taylor, a coinvestigator with Dr. Scott on the study. A propensity-score matched analysis that compared the bariatric surgery patients and matched nonsurgical patients showed very similar reductions in all three event categories.

"Bariatric surgery has a substantial and lasting mitigating association on major complications associated with type 2 diabetes in the obese population," concluded Dr. Taylor, chairman of surgery at the University Medical Center in Greenville.

Dr. Scott, Dr. Fischer, and Dr. Taylor had no relevant disclosures.

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AT THE ANNUAL MEETING OF THE SOUTHERN SURGICAL ASSOCIATION

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Major Finding: Bariatric surgery was linked to a 64% decrease in macro- and microvascular events compared with no surgery in obese type 2 diabetes patients.

Data Source: Billing information collected on 15,951 obese patients in South Carolina during 1995-2009.

Disclosures: Dr. Scott, Dr. Fischer, and Dr. Taylor had no relevant disclosures.

Long-term income growth slow for physicians

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Long-term income growth slow for physicians

Since 1987, physicians’ income growth has been exceeded by other health care professionals, according to an analysis of survey data from the Census Bureau and the Bureau of Labor Statistics.

Data from the Current Population Survey show that adjusted annual income for physicians rose 9.6% from 1987-1990 to 2006-2010, compared with increases of 54% for physician assistants, 44% for pharmacists, and 24% for registered nurses, said Seth A. Seabury, Ph.D., of the Rand Corp. in Santa Monica, Calif., and his associates.

Since the 2001-2005 survey, median annual earnings for physicians have declined from $167,478 to $157,751, they reported.

The sample for this study was 30,556 respondents who identified themselves as health professionals, including 6,258 physicians. The analysis was limited to workers older than 35 years of age.

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Since 1987, physicians’ income growth has been exceeded by other health care professionals, according to an analysis of survey data from the Census Bureau and the Bureau of Labor Statistics.

Data from the Current Population Survey show that adjusted annual income for physicians rose 9.6% from 1987-1990 to 2006-2010, compared with increases of 54% for physician assistants, 44% for pharmacists, and 24% for registered nurses, said Seth A. Seabury, Ph.D., of the Rand Corp. in Santa Monica, Calif., and his associates.

Since the 2001-2005 survey, median annual earnings for physicians have declined from $167,478 to $157,751, they reported.

The sample for this study was 30,556 respondents who identified themselves as health professionals, including 6,258 physicians. The analysis was limited to workers older than 35 years of age.

Since 1987, physicians’ income growth has been exceeded by other health care professionals, according to an analysis of survey data from the Census Bureau and the Bureau of Labor Statistics.

Data from the Current Population Survey show that adjusted annual income for physicians rose 9.6% from 1987-1990 to 2006-2010, compared with increases of 54% for physician assistants, 44% for pharmacists, and 24% for registered nurses, said Seth A. Seabury, Ph.D., of the Rand Corp. in Santa Monica, Calif., and his associates.

Since the 2001-2005 survey, median annual earnings for physicians have declined from $167,478 to $157,751, they reported.

The sample for this study was 30,556 respondents who identified themselves as health professionals, including 6,258 physicians. The analysis was limited to workers older than 35 years of age.

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Simple technique facilitates laparoscopic port closure

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Simple technique facilitates laparoscopic port closure

LAS VEGAS – Surgeons have developed a simple new suture technique using two S-retractors to close laparoscopic and robotic surgery ports without sacrificing visualization.

"This method involves minimal training and surgical skill, is quick to perform, and requires no additional instrumentation and no additional cost to the institution, surgeon, or patient," Dr. Homayara Aziz said at the 41st AAGL Global Congress.

No fewer than 29 original methods have been described in the literature for fascial closure, but many use assistance from inside the abdomen or extracorporeal assistance, and require additional ports. Others can be performed without an additional port, but may or may not provide direct visualization when securing the abdominal wall fascia and peritoneum.

Illustration by John Nyquist, MS, FAMI, CMI
A schematic of the closure technique.

With the new technique, devised at the State University of New York at Buffalo, the needle does not enter the peritoneal cavity blindly, where the bowel or other visceral organs may be present, Dr. Aziz said. Instead, the S-retractor functions as a barrier to protect the contents of the abdominal cavity, reducing the risk of visceral injuries.

The S-retractor also provides direct visualization of the different abdominal layers, exposing the needle tip during its course through the fascia. Because there is no needle tip in the intraperitoneal cavity, the procedure is safer, she said.

The two-step process starts with the surgeon inserting an S-retractor through the incision into the peritoneal cavity and then lifting the abdominal layers with the bottom of the retractor, creating a barrier between the fascia and the visceral contents. The assistant uses a second S-retractor to retract the skin, fat, and muscle in the opposite direction to expose the fascia. The surgeon then uses a needle suture to grasp the fascia, Dr. Aziz explained.

The first retractor is then rotated 180 degrees in the peritoneum by the surgeon to allow for work on the opposite side of the fascia. The second retractor, used by the assistant, is also moved to the opposite side of the abdominal wall layers to expose the fascia.

The surgeon again continues to grasp the opposite side of the fascia with the suture. The two ends are tied and the fascia is closed. If the fascial defect is greater than 10 mm, the surgeon may continue the same technique for another interrupted suture, figure of 8, or running closure, said Dr. Aziz, now a clinical instructor of obstetrics, gynecology, and reproductive science at the University of Maryland, Baltimore.

She reported on a prospective, consecutive case series involving 100 private and clinic patients in which this method was used over a 3-year period for fascial closure of total laparoscopic hysterectomies; bilateral or unilateral salpingo-oophorectomy where the port site was more than 12 mm to remove the specimen using an endocatch bag; and any robotic surgery where the ports are generally more than 8 mm.

There were no intraoperative incidents, nor was there added operative time or need to access costly instruments, she said.

No bowel injuries or port-site hernias were reported during a mean follow-up of 6 weeks post surgery and at 12-month annual follow-up.

"Closure of the fascia should remain simple, easy, cost-effective, and quick to apply," Dr. Aziz said. "It should also be safe and without any complications, and this technique described here fulfills all of these criteria."

The technique takes 5 minutes or less to learn, and has been used on at least 200 additional patients at both institutions since the current analysis was performed, Dr. Aziz said in an interview. "Many of my attendings at SUNY Buffalo call it ‘the Aziz technique’ and [it] has gained much popularity."

Dr. Aziz reported no relevant conflicts of interest.

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LAS VEGAS – Surgeons have developed a simple new suture technique using two S-retractors to close laparoscopic and robotic surgery ports without sacrificing visualization.

"This method involves minimal training and surgical skill, is quick to perform, and requires no additional instrumentation and no additional cost to the institution, surgeon, or patient," Dr. Homayara Aziz said at the 41st AAGL Global Congress.

No fewer than 29 original methods have been described in the literature for fascial closure, but many use assistance from inside the abdomen or extracorporeal assistance, and require additional ports. Others can be performed without an additional port, but may or may not provide direct visualization when securing the abdominal wall fascia and peritoneum.

Illustration by John Nyquist, MS, FAMI, CMI
A schematic of the closure technique.

With the new technique, devised at the State University of New York at Buffalo, the needle does not enter the peritoneal cavity blindly, where the bowel or other visceral organs may be present, Dr. Aziz said. Instead, the S-retractor functions as a barrier to protect the contents of the abdominal cavity, reducing the risk of visceral injuries.

The S-retractor also provides direct visualization of the different abdominal layers, exposing the needle tip during its course through the fascia. Because there is no needle tip in the intraperitoneal cavity, the procedure is safer, she said.

The two-step process starts with the surgeon inserting an S-retractor through the incision into the peritoneal cavity and then lifting the abdominal layers with the bottom of the retractor, creating a barrier between the fascia and the visceral contents. The assistant uses a second S-retractor to retract the skin, fat, and muscle in the opposite direction to expose the fascia. The surgeon then uses a needle suture to grasp the fascia, Dr. Aziz explained.

The first retractor is then rotated 180 degrees in the peritoneum by the surgeon to allow for work on the opposite side of the fascia. The second retractor, used by the assistant, is also moved to the opposite side of the abdominal wall layers to expose the fascia.

The surgeon again continues to grasp the opposite side of the fascia with the suture. The two ends are tied and the fascia is closed. If the fascial defect is greater than 10 mm, the surgeon may continue the same technique for another interrupted suture, figure of 8, or running closure, said Dr. Aziz, now a clinical instructor of obstetrics, gynecology, and reproductive science at the University of Maryland, Baltimore.

She reported on a prospective, consecutive case series involving 100 private and clinic patients in which this method was used over a 3-year period for fascial closure of total laparoscopic hysterectomies; bilateral or unilateral salpingo-oophorectomy where the port site was more than 12 mm to remove the specimen using an endocatch bag; and any robotic surgery where the ports are generally more than 8 mm.

There were no intraoperative incidents, nor was there added operative time or need to access costly instruments, she said.

No bowel injuries or port-site hernias were reported during a mean follow-up of 6 weeks post surgery and at 12-month annual follow-up.

"Closure of the fascia should remain simple, easy, cost-effective, and quick to apply," Dr. Aziz said. "It should also be safe and without any complications, and this technique described here fulfills all of these criteria."

The technique takes 5 minutes or less to learn, and has been used on at least 200 additional patients at both institutions since the current analysis was performed, Dr. Aziz said in an interview. "Many of my attendings at SUNY Buffalo call it ‘the Aziz technique’ and [it] has gained much popularity."

Dr. Aziz reported no relevant conflicts of interest.

LAS VEGAS – Surgeons have developed a simple new suture technique using two S-retractors to close laparoscopic and robotic surgery ports without sacrificing visualization.

"This method involves minimal training and surgical skill, is quick to perform, and requires no additional instrumentation and no additional cost to the institution, surgeon, or patient," Dr. Homayara Aziz said at the 41st AAGL Global Congress.

No fewer than 29 original methods have been described in the literature for fascial closure, but many use assistance from inside the abdomen or extracorporeal assistance, and require additional ports. Others can be performed without an additional port, but may or may not provide direct visualization when securing the abdominal wall fascia and peritoneum.

Illustration by John Nyquist, MS, FAMI, CMI
A schematic of the closure technique.

With the new technique, devised at the State University of New York at Buffalo, the needle does not enter the peritoneal cavity blindly, where the bowel or other visceral organs may be present, Dr. Aziz said. Instead, the S-retractor functions as a barrier to protect the contents of the abdominal cavity, reducing the risk of visceral injuries.

The S-retractor also provides direct visualization of the different abdominal layers, exposing the needle tip during its course through the fascia. Because there is no needle tip in the intraperitoneal cavity, the procedure is safer, she said.

The two-step process starts with the surgeon inserting an S-retractor through the incision into the peritoneal cavity and then lifting the abdominal layers with the bottom of the retractor, creating a barrier between the fascia and the visceral contents. The assistant uses a second S-retractor to retract the skin, fat, and muscle in the opposite direction to expose the fascia. The surgeon then uses a needle suture to grasp the fascia, Dr. Aziz explained.

The first retractor is then rotated 180 degrees in the peritoneum by the surgeon to allow for work on the opposite side of the fascia. The second retractor, used by the assistant, is also moved to the opposite side of the abdominal wall layers to expose the fascia.

The surgeon again continues to grasp the opposite side of the fascia with the suture. The two ends are tied and the fascia is closed. If the fascial defect is greater than 10 mm, the surgeon may continue the same technique for another interrupted suture, figure of 8, or running closure, said Dr. Aziz, now a clinical instructor of obstetrics, gynecology, and reproductive science at the University of Maryland, Baltimore.

She reported on a prospective, consecutive case series involving 100 private and clinic patients in which this method was used over a 3-year period for fascial closure of total laparoscopic hysterectomies; bilateral or unilateral salpingo-oophorectomy where the port site was more than 12 mm to remove the specimen using an endocatch bag; and any robotic surgery where the ports are generally more than 8 mm.

There were no intraoperative incidents, nor was there added operative time or need to access costly instruments, she said.

No bowel injuries or port-site hernias were reported during a mean follow-up of 6 weeks post surgery and at 12-month annual follow-up.

"Closure of the fascia should remain simple, easy, cost-effective, and quick to apply," Dr. Aziz said. "It should also be safe and without any complications, and this technique described here fulfills all of these criteria."

The technique takes 5 minutes or less to learn, and has been used on at least 200 additional patients at both institutions since the current analysis was performed, Dr. Aziz said in an interview. "Many of my attendings at SUNY Buffalo call it ‘the Aziz technique’ and [it] has gained much popularity."

Dr. Aziz reported no relevant conflicts of interest.

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AT THE 41ST AAGL GLOBAL CONGRESS

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Major Finding: There were no intraoperative incidents, and no bowel injuries or port site hernias, during a mean follow-up of 6 weeks post surgery and at 12 months follow-up.

Data Source: Prospective, consecutive case series of 100 patients.

Disclosures: Dr. Aziz reported no relevant conflicts of interest.

Colorectal SSIs Plummet After Targeted Improvement Project

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Colorectal SSIs Plummet After Targeted Improvement Project

Colorectal surgical site infections dropped by an average of 32% among hospitals that participated in a project designed to reduce facility-specific infection risk factors.

The project – co-sponsored by the Joint Commission Center for Transforming Healthcare and the American College of Surgeons – will result in a user-friendly online tool that can examine any hospital’s infections data and recommend detailed, site-specific interventions.

Dr. Shirin Towfigh

The commission’s Targeted Solutions Tool should be available by the middle of 2013.

"The hospitals we engaged have mastered these sophisticated change tools, and now we need to make sure this learning can be spread to others," Dr. Mark Chassin said during a press briefing. "[The new tool] will be a very easy-to-follow approach that applies all the lessons we learned – showing how to measure infection rates, figure out which contributing factors are present in their institution, and guiding them through implementations proven to address these factors."

The commission chose to tackle colorectal surgical site infections (SSIs) because they are common, dangerous, and expensive, said Dr. Chassin, president of the group. Unfortunately, risk factors don’t respond to a "one size fits all" prevention protocol. "These factors are highly variable across hospitals, suggesting that there are opportunities to improve performance."

The 2-year pilot project included seven hospitals of varying size and community demographics. The facilities tracked their colorectal SSI patterns using the American College of Surgeons National Surgical Quality Improvement Program. Each hospital then developed interventions targeted at their individual modifiable risk factors, implemented the changes, and recorded their results.

Overall, the protocol reduced colorectal SSIs by 32% – from an average of 16% to 11%. Superficial skin SSIs fell by an average of 45% over the entire study group.

The protocol improved other outcomes as well, Dr. Chassin said. The average length of stay for a colorectal surgery patient with a wound infection decreased from 15 to 13 days. Across the group, the changes were associated with a savings of almost $4 million.

The hospitals collectively identified 34 factors that greatly increased the risk of such infections. During the briefing, Dr. Jenna Lovely, the surgical pharmacotherapy manager at the Mayo Clinic, Rochester, Minn., shared some of their results (J. Am. Coll. Surg. 2011;213:83-92; 2012 [doi:10.1016/j.jamcollsurg.2012.09.009]).

Before implementation of the program, the colorectal SSI rate at Mayo was 10%. With a goal of reducing that number by at least 50%, the team examined risk factors in the preoperative, intraoperative, postoperative, and posthospitalization periods and made some changes, Dr. Lovely said.

Preoperatively, every patient now takes a shower with soap or with a chlorhexidine-based cleanser both the night before and the day of surgery.

Intraoperatively, the site is prepped with an antimicrobial cleansing agent, and the correct antibiotic is administered at 1 hour before the incision is made. If the surgery lasts more than 4 hours, a second dose of the same antibiotic is administered; cefazolin is given 24 hours after closing.

At fascia closing, the surgeon dons a complete change of gown, mask, and gloves. Closing is performed with the use of an entirely new set of instruments.

Postoperatively, everyone who comes in contact with the wound – including staff, the patient, and visitors – practices good hand hygiene. Reminder notes and hand cleanser are located prominently in rooms and all around the unit. Nurses are empowered to change dressings as needed. Wound probing occurs as needed to help expel any contaminated fluids.

Patients are discharged with infection control education and a bottle of chlorhexidine cleanser.

"These changes are embedded in the environment across the continuum of care. It’s part of the surgical unit’s culture, and this makes it easier to do the right thing. The changes also allow the surgeon to focus on doing what he does best – providing a timely and efficient surgery with the best possible outcome," Dr. Lovely said.

Implementation of these changes led to a reduction in SSI rate from 10% to 4%, and that rate has maintained this rate for 18 months.

Dr. Shirin Towfigh, a surgeon at Cedars-Sinai Medical Center in Los Angeles, said her unit experienced a similar improvement.

The project included 46 surgeons and all of the unit staff. Because the team didn’t want to dictate surgical technique, she said, their goal "was to come up with processes that would improve results independent of a surgeon’s practice. We wanted the changes to be effective, but also easy for surgeons to implement in their own practice."

By the end of the study period, the unit’s colorectal SSI rate had decreased by 50%. Since the project closed 6 months ago, that has further improved, with a total decrease of 65%.

 

 

"This is a problem colorectal surgeons have been struggling with for years," Dr. Chassin said. "We’ve always tried to get at it with the simple answer: ‘Here are 5 or 10 things everyone should do to decrease SSIs.’ That doesn’t work, because the critical factors that explain poor outcomes differ from one place to another. The best advice I can give is to look at all your contributing factors and assess where your organization falls short. Use these findings as a guide for where to focus your improvement efforts. The only way you know how to improve is to measure the cause of problems and target interventions right to them."

No disclosures were reported.

Body

This is an innovative and exciting initiative that highlights our increasing sophistication about translating new knowledge and evidence into practice. In order to improve something, you must first document that there is a problem, establish a baseline, and set a goal.

The American College of Surgeons National Surgical Quality Improvement Program and similar initiatives allow for such a structured and standardized approach for data collection and reporting. Once the problem is characterized, interventions must be designed and tested in a variety of settings to determine under what conditions they are or are not effective.

No single intervention will be effective for a multifactorial problem like surgical site infections. In order to scale up and broadly disseminate such interventions, it is necessary to assess the facilitators and barriers to change that exist in a given environment to determine which interventions have the highest likelihood of success. The program described in this article, which allows such a tailored approach to quality improvement, potentially can have a profound impact on the quality and safety of the care that we provide.

Dr. Caprice C. Greenberg is an ACS Fellow, associate professor of surgery, and director of the Wisconsin Surgical Outcomes Research at the University of Wisconsin, Madison.

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Body

This is an innovative and exciting initiative that highlights our increasing sophistication about translating new knowledge and evidence into practice. In order to improve something, you must first document that there is a problem, establish a baseline, and set a goal.

The American College of Surgeons National Surgical Quality Improvement Program and similar initiatives allow for such a structured and standardized approach for data collection and reporting. Once the problem is characterized, interventions must be designed and tested in a variety of settings to determine under what conditions they are or are not effective.

No single intervention will be effective for a multifactorial problem like surgical site infections. In order to scale up and broadly disseminate such interventions, it is necessary to assess the facilitators and barriers to change that exist in a given environment to determine which interventions have the highest likelihood of success. The program described in this article, which allows such a tailored approach to quality improvement, potentially can have a profound impact on the quality and safety of the care that we provide.

Dr. Caprice C. Greenberg is an ACS Fellow, associate professor of surgery, and director of the Wisconsin Surgical Outcomes Research at the University of Wisconsin, Madison.

Body

This is an innovative and exciting initiative that highlights our increasing sophistication about translating new knowledge and evidence into practice. In order to improve something, you must first document that there is a problem, establish a baseline, and set a goal.

The American College of Surgeons National Surgical Quality Improvement Program and similar initiatives allow for such a structured and standardized approach for data collection and reporting. Once the problem is characterized, interventions must be designed and tested in a variety of settings to determine under what conditions they are or are not effective.

No single intervention will be effective for a multifactorial problem like surgical site infections. In order to scale up and broadly disseminate such interventions, it is necessary to assess the facilitators and barriers to change that exist in a given environment to determine which interventions have the highest likelihood of success. The program described in this article, which allows such a tailored approach to quality improvement, potentially can have a profound impact on the quality and safety of the care that we provide.

Dr. Caprice C. Greenberg is an ACS Fellow, associate professor of surgery, and director of the Wisconsin Surgical Outcomes Research at the University of Wisconsin, Madison.

Title
Tailor Your Approach to Quality Improvement
Tailor Your Approach to Quality Improvement

Colorectal surgical site infections dropped by an average of 32% among hospitals that participated in a project designed to reduce facility-specific infection risk factors.

The project – co-sponsored by the Joint Commission Center for Transforming Healthcare and the American College of Surgeons – will result in a user-friendly online tool that can examine any hospital’s infections data and recommend detailed, site-specific interventions.

Dr. Shirin Towfigh

The commission’s Targeted Solutions Tool should be available by the middle of 2013.

"The hospitals we engaged have mastered these sophisticated change tools, and now we need to make sure this learning can be spread to others," Dr. Mark Chassin said during a press briefing. "[The new tool] will be a very easy-to-follow approach that applies all the lessons we learned – showing how to measure infection rates, figure out which contributing factors are present in their institution, and guiding them through implementations proven to address these factors."

The commission chose to tackle colorectal surgical site infections (SSIs) because they are common, dangerous, and expensive, said Dr. Chassin, president of the group. Unfortunately, risk factors don’t respond to a "one size fits all" prevention protocol. "These factors are highly variable across hospitals, suggesting that there are opportunities to improve performance."

The 2-year pilot project included seven hospitals of varying size and community demographics. The facilities tracked their colorectal SSI patterns using the American College of Surgeons National Surgical Quality Improvement Program. Each hospital then developed interventions targeted at their individual modifiable risk factors, implemented the changes, and recorded their results.

Overall, the protocol reduced colorectal SSIs by 32% – from an average of 16% to 11%. Superficial skin SSIs fell by an average of 45% over the entire study group.

The protocol improved other outcomes as well, Dr. Chassin said. The average length of stay for a colorectal surgery patient with a wound infection decreased from 15 to 13 days. Across the group, the changes were associated with a savings of almost $4 million.

The hospitals collectively identified 34 factors that greatly increased the risk of such infections. During the briefing, Dr. Jenna Lovely, the surgical pharmacotherapy manager at the Mayo Clinic, Rochester, Minn., shared some of their results (J. Am. Coll. Surg. 2011;213:83-92; 2012 [doi:10.1016/j.jamcollsurg.2012.09.009]).

Before implementation of the program, the colorectal SSI rate at Mayo was 10%. With a goal of reducing that number by at least 50%, the team examined risk factors in the preoperative, intraoperative, postoperative, and posthospitalization periods and made some changes, Dr. Lovely said.

Preoperatively, every patient now takes a shower with soap or with a chlorhexidine-based cleanser both the night before and the day of surgery.

Intraoperatively, the site is prepped with an antimicrobial cleansing agent, and the correct antibiotic is administered at 1 hour before the incision is made. If the surgery lasts more than 4 hours, a second dose of the same antibiotic is administered; cefazolin is given 24 hours after closing.

At fascia closing, the surgeon dons a complete change of gown, mask, and gloves. Closing is performed with the use of an entirely new set of instruments.

Postoperatively, everyone who comes in contact with the wound – including staff, the patient, and visitors – practices good hand hygiene. Reminder notes and hand cleanser are located prominently in rooms and all around the unit. Nurses are empowered to change dressings as needed. Wound probing occurs as needed to help expel any contaminated fluids.

Patients are discharged with infection control education and a bottle of chlorhexidine cleanser.

"These changes are embedded in the environment across the continuum of care. It’s part of the surgical unit’s culture, and this makes it easier to do the right thing. The changes also allow the surgeon to focus on doing what he does best – providing a timely and efficient surgery with the best possible outcome," Dr. Lovely said.

Implementation of these changes led to a reduction in SSI rate from 10% to 4%, and that rate has maintained this rate for 18 months.

Dr. Shirin Towfigh, a surgeon at Cedars-Sinai Medical Center in Los Angeles, said her unit experienced a similar improvement.

The project included 46 surgeons and all of the unit staff. Because the team didn’t want to dictate surgical technique, she said, their goal "was to come up with processes that would improve results independent of a surgeon’s practice. We wanted the changes to be effective, but also easy for surgeons to implement in their own practice."

By the end of the study period, the unit’s colorectal SSI rate had decreased by 50%. Since the project closed 6 months ago, that has further improved, with a total decrease of 65%.

 

 

"This is a problem colorectal surgeons have been struggling with for years," Dr. Chassin said. "We’ve always tried to get at it with the simple answer: ‘Here are 5 or 10 things everyone should do to decrease SSIs.’ That doesn’t work, because the critical factors that explain poor outcomes differ from one place to another. The best advice I can give is to look at all your contributing factors and assess where your organization falls short. Use these findings as a guide for where to focus your improvement efforts. The only way you know how to improve is to measure the cause of problems and target interventions right to them."

No disclosures were reported.

Colorectal surgical site infections dropped by an average of 32% among hospitals that participated in a project designed to reduce facility-specific infection risk factors.

The project – co-sponsored by the Joint Commission Center for Transforming Healthcare and the American College of Surgeons – will result in a user-friendly online tool that can examine any hospital’s infections data and recommend detailed, site-specific interventions.

Dr. Shirin Towfigh

The commission’s Targeted Solutions Tool should be available by the middle of 2013.

"The hospitals we engaged have mastered these sophisticated change tools, and now we need to make sure this learning can be spread to others," Dr. Mark Chassin said during a press briefing. "[The new tool] will be a very easy-to-follow approach that applies all the lessons we learned – showing how to measure infection rates, figure out which contributing factors are present in their institution, and guiding them through implementations proven to address these factors."

The commission chose to tackle colorectal surgical site infections (SSIs) because they are common, dangerous, and expensive, said Dr. Chassin, president of the group. Unfortunately, risk factors don’t respond to a "one size fits all" prevention protocol. "These factors are highly variable across hospitals, suggesting that there are opportunities to improve performance."

The 2-year pilot project included seven hospitals of varying size and community demographics. The facilities tracked their colorectal SSI patterns using the American College of Surgeons National Surgical Quality Improvement Program. Each hospital then developed interventions targeted at their individual modifiable risk factors, implemented the changes, and recorded their results.

Overall, the protocol reduced colorectal SSIs by 32% – from an average of 16% to 11%. Superficial skin SSIs fell by an average of 45% over the entire study group.

The protocol improved other outcomes as well, Dr. Chassin said. The average length of stay for a colorectal surgery patient with a wound infection decreased from 15 to 13 days. Across the group, the changes were associated with a savings of almost $4 million.

The hospitals collectively identified 34 factors that greatly increased the risk of such infections. During the briefing, Dr. Jenna Lovely, the surgical pharmacotherapy manager at the Mayo Clinic, Rochester, Minn., shared some of their results (J. Am. Coll. Surg. 2011;213:83-92; 2012 [doi:10.1016/j.jamcollsurg.2012.09.009]).

Before implementation of the program, the colorectal SSI rate at Mayo was 10%. With a goal of reducing that number by at least 50%, the team examined risk factors in the preoperative, intraoperative, postoperative, and posthospitalization periods and made some changes, Dr. Lovely said.

Preoperatively, every patient now takes a shower with soap or with a chlorhexidine-based cleanser both the night before and the day of surgery.

Intraoperatively, the site is prepped with an antimicrobial cleansing agent, and the correct antibiotic is administered at 1 hour before the incision is made. If the surgery lasts more than 4 hours, a second dose of the same antibiotic is administered; cefazolin is given 24 hours after closing.

At fascia closing, the surgeon dons a complete change of gown, mask, and gloves. Closing is performed with the use of an entirely new set of instruments.

Postoperatively, everyone who comes in contact with the wound – including staff, the patient, and visitors – practices good hand hygiene. Reminder notes and hand cleanser are located prominently in rooms and all around the unit. Nurses are empowered to change dressings as needed. Wound probing occurs as needed to help expel any contaminated fluids.

Patients are discharged with infection control education and a bottle of chlorhexidine cleanser.

"These changes are embedded in the environment across the continuum of care. It’s part of the surgical unit’s culture, and this makes it easier to do the right thing. The changes also allow the surgeon to focus on doing what he does best – providing a timely and efficient surgery with the best possible outcome," Dr. Lovely said.

Implementation of these changes led to a reduction in SSI rate from 10% to 4%, and that rate has maintained this rate for 18 months.

Dr. Shirin Towfigh, a surgeon at Cedars-Sinai Medical Center in Los Angeles, said her unit experienced a similar improvement.

The project included 46 surgeons and all of the unit staff. Because the team didn’t want to dictate surgical technique, she said, their goal "was to come up with processes that would improve results independent of a surgeon’s practice. We wanted the changes to be effective, but also easy for surgeons to implement in their own practice."

By the end of the study period, the unit’s colorectal SSI rate had decreased by 50%. Since the project closed 6 months ago, that has further improved, with a total decrease of 65%.

 

 

"This is a problem colorectal surgeons have been struggling with for years," Dr. Chassin said. "We’ve always tried to get at it with the simple answer: ‘Here are 5 or 10 things everyone should do to decrease SSIs.’ That doesn’t work, because the critical factors that explain poor outcomes differ from one place to another. The best advice I can give is to look at all your contributing factors and assess where your organization falls short. Use these findings as a guide for where to focus your improvement efforts. The only way you know how to improve is to measure the cause of problems and target interventions right to them."

No disclosures were reported.

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Colorectal SSIs Plummet After Targeted Improvement Project
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Colorectal SSIs Plummet After Targeted Improvement Project
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surgical site infections, hospitalization, Joint Commission Center for Transforming Healthcare, the American College of Surgeons, National Surgical Quality Improvement Program, Dr. Mark Chassin, Dr. Shirin Towfigh, colorectal surgery
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surgical site infections, hospitalization, Joint Commission Center for Transforming Healthcare, the American College of Surgeons, National Surgical Quality Improvement Program, Dr. Mark Chassin, Dr. Shirin Towfigh, colorectal surgery
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Major Finding: Implementation of a new protocol reduced colorectal surgical site infections by an average of 32% and average length of stay from 15 days to 13 days among participating hospitals.

Data Source: The results come from a pilot project co-sponsored by the Joint Commission Center for Transforming Healthcare and the American College of Surgeons.

Disclosures: No disclosures were reported.