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RT linked with better survival in DCIS
Lumpectomy plus radiotherapy is associated with a significant reduction in breast cancer mortality versus lumpectomy or mastectomy alone.
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Tailored hemophilia prophylaxis could cut costs
Tailored frequency-escalated prophylaxis resulted in less use of recombinant factor VIII.
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Bisphosphonate use linked with lower risk of lung cancer for never-smokers
Use of oral bisphosphonates was associated with a lower risk of developing lung cancer in postmenopausal women, but only those who were never...
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Fruquintinib promising agent for advanced NSCLC
Median PFS was 3.8 months with fruquintinib versus 1.1 months with placebo in heavily pretreated patients with advanced NSCLC.
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Excellent prognosis for cystic RCC evaluated with radiologic threshold of greater than 50%
There was no evidence of tumor recurrence or metastasis from cRCC for both active surveillance and following surgery when evaluated with a...
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Spray-dried plasma inches toward clinical trials
In vitro studies show strong results for spray-dried plasma, which could have implications on the battlefield.
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Sotatercept promising for treatment of anemia in MDS
The phase 2 trial included patients who did not respond to erythropoiesis-stimulating agents.
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Age at RRSO affects peritoneal cancer risk in BRCA mutation carriers
The risk was predominantly observed in BRCA1 mutation carriers, and disease development generally occurred within 5 years following RRSO.
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A mismatched haplotype may improve outcomes in second BMT
Mortality risk was highest in patients who had progressive or refractory disease before a second transplant, or who relapsed within 6 months of a...
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Wider margins may reduce recurrence risk in early breast cancer
SAN ANTONIO – Updated analysis fails to confirm that ‘no-tumor on ink’ is optimal.
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Enzalutamide plus exemestane improves PFS in HR+ breast cancer subset
SAN ANTONIO – The combo improved outcomes in those who had not received prior endocrine therapy and who were positive for androgen receptor...
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Lapatinib plus trastuzumab improves outcomes in HER2+ breast cancer
SAN ANTONIO – Results from CALGB 40601 conflict with those from two larger trials that failed to find a benefit for dual HER2 blockade in treating...
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Axillary node dissection can be avoided with limited SLN involvement
SAN ANTONIO – Long-term follow-up confirms findings at 5 years, that DFS was similar for cohorts randomized to AD or no AD.
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ERBB2 expression predicts pCR in HER2+ breast cancer
In the phase 3 NeoALTTO trial, the amplification of ERBB2 was shown to be predictive of pCR; its expression was more predictive of pCR.
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Zika RNA persists in blood components after clearance from plasma
Zika RNA can persist in blood components for about up to 3 months.