Sharon Worcester is an award-winning medical journalist for MDedge News. She has been with the company since 1996, first as the Southeast Bureau Chief (1996-2009) when the company was known as International Medical News Group, then as a freelance writer (2010-2015) before returning as a reporter in 2015. She previously worked as a daily newspaper reporter covering health and local government. Sharon currently reports primarily on oncology and hematology. She has a BA from Eckerd College and an MA in Mass Communication/Print Journalism from the University of Florida. Connect with her via LinkedIn and follow her on twitter @SW_MedReporter.
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Analysis of early onset cancers suggests need for genetic testing
The prevalence of germline mutations was significantly higher in patients with early onset cancers than in those with young adult cancers.
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AI markers can predict progression, survival in prostate cancer
Artificial intelligence–based Gleason scores correlated with pathologists’ Gleason scores.
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Lipophilic statins linked to lower mortality in ovarian cancer
Lipophilic statin use was associated with a 43% reduction in mortality.
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Novel SERD, LSZ102, shows promise for pretreated ER+ breast cancer
LSZ102 was relatively well tolerated as a single agent and in combination with ribociclib and alperisib.
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Tumor markers are ‘valuable’ for relapse detection in rare CNS tumors
Among evaluable patients, 92% of relapses were detectable by tumor markers.
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Sequential chemoradiation improves DFS in early-stage cervical cancer
The 3-year disease-free survival rate was significantly higher among patients who received sequential chemoradiation than among patients who...
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Immunotherapy combo improves ORR, PFS in PD-L1+ NSCLC
Adding tiragolumab to atezolizumab led to “clinically meaningful” improvements in patients with PD-L1–positive non–small cell lung cancer.
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No OS benefit with gefitinib vs. chemo for EGFR+ NSCLC
Adjuvant gefitinib improved disease-free survival, but not overall survival, when compared with standard chemotherapy.
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Addressing racism, bias in the American maternal mortality crisis
“I think the most important thing you can do is really consider a patient a partner in the care you give them.”
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Poziotinib provides ‘modest but meaningful’ efficacy in NSCLC subgroup
About 15% of patients achieved a response with poziotinib and 65% had a decrease in tumor size.
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ALTERNATE trial: No fulvestrant benefit in locally advanced ER+ HER2– breast cancer
The endocrine-sensitive disease rate was similar whether patients received anastrozole alone, fulvestrant alone, or fulvestrant plus anastrozole...
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LOTUS: Ipatasertib plus paclitaxel may prolong OS in TNBC
Ipatasertib provided a “clinically meaningful,” but not statistically significant, 9-month improvement in median overall survival.
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Novel penclomedine shows promise for some AYAs with CNS cancers
Two patients who responded to the treatment were in their 59th month of survival at last follow-up.
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Universal CAR-T therapy produces CRs in relapsed/refractory T-ALL
All five patients studied achieved a complete response, though one patient had a morphological relapse.
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MRD surveillance can detect relapse before imaging in early-stage NSCLC
Relapse occurred in 9 of 10 patients who were positive for minimal residual disease but had no evidence of relapse on imaging.