Clinical Review

Dr. Duff reports no financial relationships relevant to this article.

Four important developments have marked the past year in infectious disease:

• A promising vaccine against cytomegalovirus (CMV) was tested in women of reproductive age
• Extended-spectrum antibiotic prophylaxis proved to be effective in reducing the incidence of wound infection following cesarean delivery
• Investigators developed a simple but effective method to prevent wound complications following repair of a third- or fourth-degree perineal laceration
• The incidence of severe Clostridium difficile-associated diarrhea crept upward, emerging as a threat to pregnant women.

CMV vaccine makes an auspicious debut—but isn’t ready for practice

Pass RF, Zhang C, Evans A, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med. 2009; 360:1191–1199 [Classification of evidence – Level I].

This Phase-2, randomized, double-blind, placebo-controlled trial of a new cytomegalovirus (CMV) vaccine in women found an overall efficacy rate of 50% (95% confidence interval, 7% to 73%), with no unusually serious reactions among women who were vaccinated. This efficacy rate is disappointing, but it isn’t entirely surprising; even the immune response resulting from natural infection is not fully protective against reactivated infection or recurrent infection with a different strain of virus. Nor is natural immunity completely effective in preventing severe fetal injury in recurrent infection.¹

Virus poses greatest risk to pregnant women and their fetuses

CMV is the most common perinatally transmitted infection, affecting 0.6% to 0.7% of infants ( FIGURE 1 ). The greatest risk of fetal injury occurs when the mother develops primary infection during pregnancy, which raises her infant’s risk of infection to 40% to 50%. Of infants delivered to mothers with primary infection, approximately 10% to 15% will be acutely symptomatic at birth.

Clinical manifestations of severe congenital CMV infection include growth restriction, microcephaly, ventriculomegaly, intracranial calcification, chorioretinitis, hearing impairment, hepatitis, and thrombocytopenia.

Because the morbidity and mortality associated with these conditions are alarmingly high, development of a safe, effective vaccine against CMV would be most welcome.^2,3

Recurrent or reactivated maternal CMV infection poses a much lower risk to the fetus. Infected infants are rarely symptomatic at birth. Clinical manifestations of infection typically occur later in childhood and include hearing and visual deficits, dental anomalies, and learning or behavioral disorders.^2,3

FIGURE 1 Cytomegalovirus

Cytomegalovirus is a member of the herpesvirus family. It is shed intermittently in bodily fluids, without detectable signs and symptoms.

Details of the trial

Women were eligible for the study if they were seronegative for CMV antibody, in good health, 14 to 40 years old, and not pregnant or lactating. Participants received three doses of vaccine or placebo at 0, 1, and 6 months. (The vaccine was composed of CMV envelope glycoprotein B with MF59 adjuvant.) The women were then tested for CMV infection every 3 months for as long as 42 months, using an assay for IgG antibodies directed against viral proteins other than glycoprotein B. Infection was confirmed by viral culture or immuno blotting. The primary endpoint was time until detection of CMV infection.

The vaccine was given to 234 patients, and 230 received placebo. Eighteen infections occurred in the vaccine group, compared with 31 in the placebo group. Vaccinated patients were more likely to remain uninfected during follow-up (p=.02).

One of 81 infants (1%) born to mothers in the vaccinated group had congenital CMV infection, compared with three of 97 (3%) infants born to mothers in the placebo group (p=.41). One infant in the placebo group had severe infection that was evident at birth. The other three infants were asymptomatic at birth and free of sequelae 3 to 5 years later.

The most promising preventive remains experimental

No drug is uniformly effective in treating maternal CMV infection and preventing congenital infection. The most promising intervention for prevention of congenital CMV infection is administration of hyperimmune anti-CMV antibody to the mother. A recent report by Nigro and colleagues⁴ found this agent to be of great value for both treating and preventing congenital CMV. However, because of limitations in the design of this study, administration of hyperimmune globulin still must be regarded as experimental.³

Key questions remain unanswered

The goal of a large-scale vaccination program is to ensure that women enter reproductive age with preexisting immunity to infection. In that light, the study by Pass and colleagues is only partially encouraging. Despite vaccination, 18 infections occurred, and the follow-up period was relatively short. We do not yet know whether the protective effect of the vaccine will be of extended duration. Moreover, one vaccinated mother delivered an infant who had congenital CMV infection.

 

Extended-spectrum antibiotics reduce the rate of postcesarean wound infection

Tita ATN, Owen J, Stamm AM, Grimes A, Hauth JC, Andrews WW. Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection. Am J Obstet Gynecol. 2008;199:303e.1–303e.3 [Classification of evidence – Level II].

This prospective study describes surveillance for postcesarean wound infection during three different periods at the University of Alabama:

• 1992–1996, during which patients undergoing cesarean delivery routinely received prophylaxis with a first- or second-generation cephalosporin. Overall incidence of wound infection: 3.1%
• 1997–1999, during which patients were randomized to standard prophylaxis with cefazolin or to cefazolin plus either intravenous (IV) doxycycline or oral azithromycin. Overall incidence of wound infection: 2.4%
• 2001–2006, during which patients routinely received IV cefazolin plus IV azithromycin. Overall incidence of wound infection: 1.3%.

In each time period, the prophylactic antibiotics were administered after the infant’s umbilical cord was clamped. The p value for test of trend was highly significant (p<.002). The same significant trend was noted when superficial and deep wound infections were examined separately.

This evidence is a “practice changer”

For almost 20 years, the standard of practice has been to routinely administer prophylactic antibiotics to all women having cesarean delivery. Essentially, every published study has demonstrated a highly significant reduction in the frequency of postcesarean endometritis when patients received prophylaxis. Multiple studies also confirmed that a more limited-spectrum cephalosporin was as effective as an extended-spectrum agent in reducing the frequency of endometritis.⁵

Many of these earlier reports were unable to demonstrate a consistently beneficial effect of prophylaxis on the incidence of postoperative wound infection. That is why the present study is of such interest and importance. Tita and colleagues previously demonstrated an improved effect of extended-spectrum prophylaxis on the incidence of postcesarean endometritis.⁶ Now they have confirmed that this method of prophylaxis is also effective in lowering the rate of surgical wound infection.

Wound infections are more troublesome than endometritis

Wound infections—either incisional abscess or cellulitis—are even more likely than post-cesarean endometritis to prolong a patient’s postoperative stay and create the potential for severe morbidity, such as fascial dehiscence and necrotizing fasciitis. With the increasing prevalence of obesity in the US population, wound infections are likely to become even more frequent.

These infections typically are caused by aerobic streptococci and staphylococci from the skin, combined with coliform organisms and anaerobes from the pelvic flora. Incisional abscesses require surgical drainage; cellulitis usually will respond to a change in antibiotic therapy that specifically targets streptococci and staphylococci, along with the coliforms and anaerobes.

Prophylactic antibiotics reduce the complication rate by 2/3 after repair of major perineal laceration

Duggal N, Mercado C, Daniels K, Bujor A, Caughey AB, El-Sayed YY. Antibiotic prophylaxis for prevention of postpartum perineal wound complications: a randomized control trial. Obstet Gynecol. 2008;111:1268–1273 [Classification of evidence – Level I].

Take note of this prospective, randomized, placebo-controlled trial of prophylactic antibiotics in women who sustained a third-or fourth-degree perineal laceration during vaginal delivery: It is the first, and only, well-designed trial of antibiotic prophylaxis for prevention of complications after repair of a major perineal laceration. Among patients in the study, 8% who received antibiotics developed a wound complication, compared with 24% of patients who received placebo, a statistically and clinically significant difference.

Details of the study

Eighty-three women received placebo, and 64 received a single IV dose of either cefotetan (1 g) or cefoxitin (1 g) before their perineal laceration was repaired. Patients who were allergic to penicillin received clindamycin (900 mg). The primary endpoints of the study were gross disruption of the wound or purulent drainage from the wound site 2 weeks after delivery.

Forty patients (27%) did not return for their post-partum appointment. Of the remaining patients, four of 49 (8%) who received antibiotics developed a wound complication, compared with 14 of 58 (24%) of those who received placebo (p=.037).

 

Sequelae of major perineal laceration can be severe

Major perineal laceration occurs in approximately 2% to 20% of vaginal deliveries in the United States. The principal risk factors for third- and fourth-degree lacerations are nulliparity, midline episiotomy, and operative vaginal delivery, especially forceps extraction. Both types of laceration may lead to serious morbidity, such as prolonged pain, fecal incontinence, and perineal infection, including necrotizing fasciitis. These infections typically are polymicrobial, mixed aerobic–anaerobic. Moreover, fourth-degree lacerations may result in rectovaginal fistula if they are not repaired properly. This complication causes considerable debility and major social inconvenience for the patient.

Although the sample size was relatively small, this study clearly demonstrated that a single dose of extended-spectrum cephalosporin (cefotetan or cefoxitin) was highly effective in reducing the rate of perineal infection and perineal wound disruption. Whether a more limited-spectrum agent such as cefazolin would be as effective is not certain.

Diarrhea linked to Clostridium difficile emerges as a potent threat to pregnant women

Rouphael NG, O’Donnell JA, Bhatnagar J, et al. Clostridium difficile-associated diarrhea: an emerging threat to pregnant women. Am J Obstet Gynecol. 2008;198:635.e1–635.e6 [Classification of evidence – Level III].

This report describes 10 cases of severe Clostridium difficile-associated diarrhea (CDAD) in pregnant women during 2005 and 2006. CDAD usually affects elderly debilitated patients in hospitals and nursing homes. This report is of great concern because the affected patients were otherwise healthy, young, pregnant women. The observations are even more alarming because the mortality rate in this small series was 30% for both mothers and babies.

Details of the series

The women developed signs of severe CDAD 3 to 60 days after receiving antibiotics; the median was 5 days. CDAD was considered severe if the patient required hospitalization, ICU admission, or colectomy, or if she died. These cases occurred in California, Georgia, Oklahoma, and Pennsylvania and were reported to the Centers for Disease Control and Prevention (CDC).

Six women became ill before delivery, and four developed symptoms postpartum. The most common manifestations of infection were diarrhea, abdominal pain and distention, and fever. The peripheral white blood cell count was in the range of 11–72 × 10³/μL. In nine patients, the diagnosis was confirmed by a positive test for toxin A/B; seven of these patients also had visible pseudomembranes in the colon. One patient had a positive stool sample for C difficile ( FIGURE 2 ).

Six patients required admission to the ICU. Six developed toxic megacolon, and five required subtotal colectomy. Three had sepsis; three had acute renal failure; two had disseminated intravascular coagulation. Three patients died, and three had stillbirths. Two patients relapsed following treatment.

One patient had no treatment and died. The others received either metronidazole or vancomycin or a combination of the two. One of the patients who died received metronidazole, vancomycin, and cholestyramine.

FIGURE 2 Clostridium difficile

C difficile is a spore-forming, gram-positive anaerobic bacillus that is a common cause of antibiotic-associated diarrhea.

An epidemic strain appears

The incidence of C difficile infection in acute care US hospitals has increased to 84 for every 100,000 patients in recent years, about three times the rate of 31 for every 100,000 that was reported in 1996, as the authors note. Many of the most severe cases of CDAD are caused by a new epidemic strain of bacteria, termed North American Pulsed Field type 1 (NAP1) and PCR ribotype 027.

This new strain is characterized by three key virulence factors:

• increased production of toxins A and B
• resistance to fluoroquinolones
• production of binary toxin.

Toxins A and B bind to the surface of intestinal epithelial cells, stimulate tissue injury and inflammation, and, ultimately, lead to cell death. Binary toxin appears to act synergistically with toxins A and B to cause severe colitis.⁹

Metronidazole is no longer the treatment of choice for severe CDAD

Before 2000, treatment of CDAD with vancomycin or metronidazole was 97% to 98% effective.⁹ In recent years, however, a failure rate as high as 26% has been reported among patients who are treated with metronidazole.¹⁰ One prospective, randomized clinical trial demonstrated that, in patients who had severe CDAD, vancomycin, 125 mg four times daily, was superior to metronidazole, 250 mg four times daily (97% success rate vs 76%; p=.02).¹¹ The efficacy of the two drugs was comparable in treating milder cases of CDAD (98% for vancomycin, 90% for metronidazole; p=.36).

 

Dr. Duff reports no financial relationships relevant to this article.

Four important developments have marked the past year in infectious disease:

• A promising vaccine against cytomegalovirus (CMV) was tested in women of reproductive age
• Extended-spectrum antibiotic prophylaxis proved to be effective in reducing the incidence of wound infection following cesarean delivery
• Investigators developed a simple but effective method to prevent wound complications following repair of a third- or fourth-degree perineal laceration
• The incidence of severe Clostridium difficile-associated diarrhea crept upward, emerging as a threat to pregnant women.

CMV vaccine makes an auspicious debut—but isn’t ready for practice

Pass RF, Zhang C, Evans A, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med. 2009; 360:1191–1199 [Classification of evidence – Level I].

This Phase-2, randomized, double-blind, placebo-controlled trial of a new cytomegalovirus (CMV) vaccine in women found an overall efficacy rate of 50% (95% confidence interval, 7% to 73%), with no unusually serious reactions among women who were vaccinated. This efficacy rate is disappointing, but it isn’t entirely surprising; even the immune response resulting from natural infection is not fully protective against reactivated infection or recurrent infection with a different strain of virus. Nor is natural immunity completely effective in preventing severe fetal injury in recurrent infection.¹

Virus poses greatest risk to pregnant women and their fetuses

CMV is the most common perinatally transmitted infection, affecting 0.6% to 0.7% of infants ( FIGURE 1 ). The greatest risk of fetal injury occurs when the mother develops primary infection during pregnancy, which raises her infant’s risk of infection to 40% to 50%. Of infants delivered to mothers with primary infection, approximately 10% to 15% will be acutely symptomatic at birth.

Clinical manifestations of severe congenital CMV infection include growth restriction, microcephaly, ventriculomegaly, intracranial calcification, chorioretinitis, hearing impairment, hepatitis, and thrombocytopenia.

Because the morbidity and mortality associated with these conditions are alarmingly high, development of a safe, effective vaccine against CMV would be most welcome.^2,3

Recurrent or reactivated maternal CMV infection poses a much lower risk to the fetus. Infected infants are rarely symptomatic at birth. Clinical manifestations of infection typically occur later in childhood and include hearing and visual deficits, dental anomalies, and learning or behavioral disorders.^2,3

FIGURE 1 Cytomegalovirus

Cytomegalovirus is a member of the herpesvirus family. It is shed intermittently in bodily fluids, without detectable signs and symptoms.

Details of the trial

Women were eligible for the study if they were seronegative for CMV antibody, in good health, 14 to 40 years old, and not pregnant or lactating. Participants received three doses of vaccine or placebo at 0, 1, and 6 months. (The vaccine was composed of CMV envelope glycoprotein B with MF59 adjuvant.) The women were then tested for CMV infection every 3 months for as long as 42 months, using an assay for IgG antibodies directed against viral proteins other than glycoprotein B. Infection was confirmed by viral culture or immuno blotting. The primary endpoint was time until detection of CMV infection.

The vaccine was given to 234 patients, and 230 received placebo. Eighteen infections occurred in the vaccine group, compared with 31 in the placebo group. Vaccinated patients were more likely to remain uninfected during follow-up (p=.02).

One of 81 infants (1%) born to mothers in the vaccinated group had congenital CMV infection, compared with three of 97 (3%) infants born to mothers in the placebo group (p=.41). One infant in the placebo group had severe infection that was evident at birth. The other three infants were asymptomatic at birth and free of sequelae 3 to 5 years later.

The most promising preventive remains experimental

No drug is uniformly effective in treating maternal CMV infection and preventing congenital infection. The most promising intervention for prevention of congenital CMV infection is administration of hyperimmune anti-CMV antibody to the mother. A recent report by Nigro and colleagues⁴ found this agent to be of great value for both treating and preventing congenital CMV. However, because of limitations in the design of this study, administration of hyperimmune globulin still must be regarded as experimental.³

Key questions remain unanswered

The goal of a large-scale vaccination program is to ensure that women enter reproductive age with preexisting immunity to infection. In that light, the study by Pass and colleagues is only partially encouraging. Despite vaccination, 18 infections occurred, and the follow-up period was relatively short. We do not yet know whether the protective effect of the vaccine will be of extended duration. Moreover, one vaccinated mother delivered an infant who had congenital CMV infection.

 

Extended-spectrum antibiotics reduce the rate of postcesarean wound infection

Tita ATN, Owen J, Stamm AM, Grimes A, Hauth JC, Andrews WW. Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection. Am J Obstet Gynecol. 2008;199:303e.1–303e.3 [Classification of evidence – Level II].

This prospective study describes surveillance for postcesarean wound infection during three different periods at the University of Alabama:

• 1992–1996, during which patients undergoing cesarean delivery routinely received prophylaxis with a first- or second-generation cephalosporin. Overall incidence of wound infection: 3.1%
• 1997–1999, during which patients were randomized to standard prophylaxis with cefazolin or to cefazolin plus either intravenous (IV) doxycycline or oral azithromycin. Overall incidence of wound infection: 2.4%
• 2001–2006, during which patients routinely received IV cefazolin plus IV azithromycin. Overall incidence of wound infection: 1.3%.

In each time period, the prophylactic antibiotics were administered after the infant’s umbilical cord was clamped. The p value for test of trend was highly significant (p<.002). The same significant trend was noted when superficial and deep wound infections were examined separately.

This evidence is a “practice changer”

For almost 20 years, the standard of practice has been to routinely administer prophylactic antibiotics to all women having cesarean delivery. Essentially, every published study has demonstrated a highly significant reduction in the frequency of postcesarean endometritis when patients received prophylaxis. Multiple studies also confirmed that a more limited-spectrum cephalosporin was as effective as an extended-spectrum agent in reducing the frequency of endometritis.⁵

Many of these earlier reports were unable to demonstrate a consistently beneficial effect of prophylaxis on the incidence of postoperative wound infection. That is why the present study is of such interest and importance. Tita and colleagues previously demonstrated an improved effect of extended-spectrum prophylaxis on the incidence of postcesarean endometritis.⁶ Now they have confirmed that this method of prophylaxis is also effective in lowering the rate of surgical wound infection.

Wound infections are more troublesome than endometritis

Wound infections—either incisional abscess or cellulitis—are even more likely than post-cesarean endometritis to prolong a patient’s postoperative stay and create the potential for severe morbidity, such as fascial dehiscence and necrotizing fasciitis. With the increasing prevalence of obesity in the US population, wound infections are likely to become even more frequent.

These infections typically are caused by aerobic streptococci and staphylococci from the skin, combined with coliform organisms and anaerobes from the pelvic flora. Incisional abscesses require surgical drainage; cellulitis usually will respond to a change in antibiotic therapy that specifically targets streptococci and staphylococci, along with the coliforms and anaerobes.

Prophylactic antibiotics reduce the complication rate by 2/3 after repair of major perineal laceration

Duggal N, Mercado C, Daniels K, Bujor A, Caughey AB, El-Sayed YY. Antibiotic prophylaxis for prevention of postpartum perineal wound complications: a randomized control trial. Obstet Gynecol. 2008;111:1268–1273 [Classification of evidence – Level I].

Take note of this prospective, randomized, placebo-controlled trial of prophylactic antibiotics in women who sustained a third-or fourth-degree perineal laceration during vaginal delivery: It is the first, and only, well-designed trial of antibiotic prophylaxis for prevention of complications after repair of a major perineal laceration. Among patients in the study, 8% who received antibiotics developed a wound complication, compared with 24% of patients who received placebo, a statistically and clinically significant difference.

Details of the study

Eighty-three women received placebo, and 64 received a single IV dose of either cefotetan (1 g) or cefoxitin (1 g) before their perineal laceration was repaired. Patients who were allergic to penicillin received clindamycin (900 mg). The primary endpoints of the study were gross disruption of the wound or purulent drainage from the wound site 2 weeks after delivery.

Forty patients (27%) did not return for their post-partum appointment. Of the remaining patients, four of 49 (8%) who received antibiotics developed a wound complication, compared with 14 of 58 (24%) of those who received placebo (p=.037).

 

Sequelae of major perineal laceration can be severe

Major perineal laceration occurs in approximately 2% to 20% of vaginal deliveries in the United States. The principal risk factors for third- and fourth-degree lacerations are nulliparity, midline episiotomy, and operative vaginal delivery, especially forceps extraction. Both types of laceration may lead to serious morbidity, such as prolonged pain, fecal incontinence, and perineal infection, including necrotizing fasciitis. These infections typically are polymicrobial, mixed aerobic–anaerobic. Moreover, fourth-degree lacerations may result in rectovaginal fistula if they are not repaired properly. This complication causes considerable debility and major social inconvenience for the patient.

Although the sample size was relatively small, this study clearly demonstrated that a single dose of extended-spectrum cephalosporin (cefotetan or cefoxitin) was highly effective in reducing the rate of perineal infection and perineal wound disruption. Whether a more limited-spectrum agent such as cefazolin would be as effective is not certain.

Diarrhea linked to Clostridium difficile emerges as a potent threat to pregnant women

Rouphael NG, O’Donnell JA, Bhatnagar J, et al. Clostridium difficile-associated diarrhea: an emerging threat to pregnant women. Am J Obstet Gynecol. 2008;198:635.e1–635.e6 [Classification of evidence – Level III].

This report describes 10 cases of severe Clostridium difficile-associated diarrhea (CDAD) in pregnant women during 2005 and 2006. CDAD usually affects elderly debilitated patients in hospitals and nursing homes. This report is of great concern because the affected patients were otherwise healthy, young, pregnant women. The observations are even more alarming because the mortality rate in this small series was 30% for both mothers and babies.

Details of the series

The women developed signs of severe CDAD 3 to 60 days after receiving antibiotics; the median was 5 days. CDAD was considered severe if the patient required hospitalization, ICU admission, or colectomy, or if she died. These cases occurred in California, Georgia, Oklahoma, and Pennsylvania and were reported to the Centers for Disease Control and Prevention (CDC).

Six women became ill before delivery, and four developed symptoms postpartum. The most common manifestations of infection were diarrhea, abdominal pain and distention, and fever. The peripheral white blood cell count was in the range of 11–72 × 10³/μL. In nine patients, the diagnosis was confirmed by a positive test for toxin A/B; seven of these patients also had visible pseudomembranes in the colon. One patient had a positive stool sample for C difficile ( FIGURE 2 ).

Six patients required admission to the ICU. Six developed toxic megacolon, and five required subtotal colectomy. Three had sepsis; three had acute renal failure; two had disseminated intravascular coagulation. Three patients died, and three had stillbirths. Two patients relapsed following treatment.

One patient had no treatment and died. The others received either metronidazole or vancomycin or a combination of the two. One of the patients who died received metronidazole, vancomycin, and cholestyramine.

FIGURE 2 Clostridium difficile

C difficile is a spore-forming, gram-positive anaerobic bacillus that is a common cause of antibiotic-associated diarrhea.

An epidemic strain appears

The incidence of C difficile infection in acute care US hospitals has increased to 84 for every 100,000 patients in recent years, about three times the rate of 31 for every 100,000 that was reported in 1996, as the authors note. Many of the most severe cases of CDAD are caused by a new epidemic strain of bacteria, termed North American Pulsed Field type 1 (NAP1) and PCR ribotype 027.

This new strain is characterized by three key virulence factors:

• increased production of toxins A and B
• resistance to fluoroquinolones
• production of binary toxin.

Toxins A and B bind to the surface of intestinal epithelial cells, stimulate tissue injury and inflammation, and, ultimately, lead to cell death. Binary toxin appears to act synergistically with toxins A and B to cause severe colitis.⁹

Metronidazole is no longer the treatment of choice for severe CDAD

Before 2000, treatment of CDAD with vancomycin or metronidazole was 97% to 98% effective.⁹ In recent years, however, a failure rate as high as 26% has been reported among patients who are treated with metronidazole.¹⁰ One prospective, randomized clinical trial demonstrated that, in patients who had severe CDAD, vancomycin, 125 mg four times daily, was superior to metronidazole, 250 mg four times daily (97% success rate vs 76%; p=.02).¹¹ The efficacy of the two drugs was comparable in treating milder cases of CDAD (98% for vancomycin, 90% for metronidazole; p=.36).

 

Dr. Duff reports no financial relationships relevant to this article.

Four important developments have marked the past year in infectious disease:

• A promising vaccine against cytomegalovirus (CMV) was tested in women of reproductive age
• Extended-spectrum antibiotic prophylaxis proved to be effective in reducing the incidence of wound infection following cesarean delivery
• Investigators developed a simple but effective method to prevent wound complications following repair of a third- or fourth-degree perineal laceration
• The incidence of severe Clostridium difficile-associated diarrhea crept upward, emerging as a threat to pregnant women.

CMV vaccine makes an auspicious debut—but isn’t ready for practice

Pass RF, Zhang C, Evans A, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med. 2009; 360:1191–1199 [Classification of evidence – Level I].

This Phase-2, randomized, double-blind, placebo-controlled trial of a new cytomegalovirus (CMV) vaccine in women found an overall efficacy rate of 50% (95% confidence interval, 7% to 73%), with no unusually serious reactions among women who were vaccinated. This efficacy rate is disappointing, but it isn’t entirely surprising; even the immune response resulting from natural infection is not fully protective against reactivated infection or recurrent infection with a different strain of virus. Nor is natural immunity completely effective in preventing severe fetal injury in recurrent infection.¹

Virus poses greatest risk to pregnant women and their fetuses

CMV is the most common perinatally transmitted infection, affecting 0.6% to 0.7% of infants ( FIGURE 1 ). The greatest risk of fetal injury occurs when the mother develops primary infection during pregnancy, which raises her infant’s risk of infection to 40% to 50%. Of infants delivered to mothers with primary infection, approximately 10% to 15% will be acutely symptomatic at birth.

Clinical manifestations of severe congenital CMV infection include growth restriction, microcephaly, ventriculomegaly, intracranial calcification, chorioretinitis, hearing impairment, hepatitis, and thrombocytopenia.

Because the morbidity and mortality associated with these conditions are alarmingly high, development of a safe, effective vaccine against CMV would be most welcome.^2,3

Recurrent or reactivated maternal CMV infection poses a much lower risk to the fetus. Infected infants are rarely symptomatic at birth. Clinical manifestations of infection typically occur later in childhood and include hearing and visual deficits, dental anomalies, and learning or behavioral disorders.^2,3

FIGURE 1 Cytomegalovirus

Cytomegalovirus is a member of the herpesvirus family. It is shed intermittently in bodily fluids, without detectable signs and symptoms.

Details of the trial

Women were eligible for the study if they were seronegative for CMV antibody, in good health, 14 to 40 years old, and not pregnant or lactating. Participants received three doses of vaccine or placebo at 0, 1, and 6 months. (The vaccine was composed of CMV envelope glycoprotein B with MF59 adjuvant.) The women were then tested for CMV infection every 3 months for as long as 42 months, using an assay for IgG antibodies directed against viral proteins other than glycoprotein B. Infection was confirmed by viral culture or immuno blotting. The primary endpoint was time until detection of CMV infection.

The vaccine was given to 234 patients, and 230 received placebo. Eighteen infections occurred in the vaccine group, compared with 31 in the placebo group. Vaccinated patients were more likely to remain uninfected during follow-up (p=.02).

One of 81 infants (1%) born to mothers in the vaccinated group had congenital CMV infection, compared with three of 97 (3%) infants born to mothers in the placebo group (p=.41). One infant in the placebo group had severe infection that was evident at birth. The other three infants were asymptomatic at birth and free of sequelae 3 to 5 years later.

The most promising preventive remains experimental

No drug is uniformly effective in treating maternal CMV infection and preventing congenital infection. The most promising intervention for prevention of congenital CMV infection is administration of hyperimmune anti-CMV antibody to the mother. A recent report by Nigro and colleagues⁴ found this agent to be of great value for both treating and preventing congenital CMV. However, because of limitations in the design of this study, administration of hyperimmune globulin still must be regarded as experimental.³

Key questions remain unanswered

The goal of a large-scale vaccination program is to ensure that women enter reproductive age with preexisting immunity to infection. In that light, the study by Pass and colleagues is only partially encouraging. Despite vaccination, 18 infections occurred, and the follow-up period was relatively short. We do not yet know whether the protective effect of the vaccine will be of extended duration. Moreover, one vaccinated mother delivered an infant who had congenital CMV infection.

 

Extended-spectrum antibiotics reduce the rate of postcesarean wound infection

Tita ATN, Owen J, Stamm AM, Grimes A, Hauth JC, Andrews WW. Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection. Am J Obstet Gynecol. 2008;199:303e.1–303e.3 [Classification of evidence – Level II].

This prospective study describes surveillance for postcesarean wound infection during three different periods at the University of Alabama:

• 1992–1996, during which patients undergoing cesarean delivery routinely received prophylaxis with a first- or second-generation cephalosporin. Overall incidence of wound infection: 3.1%
• 1997–1999, during which patients were randomized to standard prophylaxis with cefazolin or to cefazolin plus either intravenous (IV) doxycycline or oral azithromycin. Overall incidence of wound infection: 2.4%
• 2001–2006, during which patients routinely received IV cefazolin plus IV azithromycin. Overall incidence of wound infection: 1.3%.

In each time period, the prophylactic antibiotics were administered after the infant’s umbilical cord was clamped. The p value for test of trend was highly significant (p<.002). The same significant trend was noted when superficial and deep wound infections were examined separately.

This evidence is a “practice changer”

For almost 20 years, the standard of practice has been to routinely administer prophylactic antibiotics to all women having cesarean delivery. Essentially, every published study has demonstrated a highly significant reduction in the frequency of postcesarean endometritis when patients received prophylaxis. Multiple studies also confirmed that a more limited-spectrum cephalosporin was as effective as an extended-spectrum agent in reducing the frequency of endometritis.⁵

Many of these earlier reports were unable to demonstrate a consistently beneficial effect of prophylaxis on the incidence of postoperative wound infection. That is why the present study is of such interest and importance. Tita and colleagues previously demonstrated an improved effect of extended-spectrum prophylaxis on the incidence of postcesarean endometritis.⁶ Now they have confirmed that this method of prophylaxis is also effective in lowering the rate of surgical wound infection.

Wound infections are more troublesome than endometritis

Wound infections—either incisional abscess or cellulitis—are even more likely than post-cesarean endometritis to prolong a patient’s postoperative stay and create the potential for severe morbidity, such as fascial dehiscence and necrotizing fasciitis. With the increasing prevalence of obesity in the US population, wound infections are likely to become even more frequent.

These infections typically are caused by aerobic streptococci and staphylococci from the skin, combined with coliform organisms and anaerobes from the pelvic flora. Incisional abscesses require surgical drainage; cellulitis usually will respond to a change in antibiotic therapy that specifically targets streptococci and staphylococci, along with the coliforms and anaerobes.

Prophylactic antibiotics reduce the complication rate by 2/3 after repair of major perineal laceration

Duggal N, Mercado C, Daniels K, Bujor A, Caughey AB, El-Sayed YY. Antibiotic prophylaxis for prevention of postpartum perineal wound complications: a randomized control trial. Obstet Gynecol. 2008;111:1268–1273 [Classification of evidence – Level I].

Take note of this prospective, randomized, placebo-controlled trial of prophylactic antibiotics in women who sustained a third-or fourth-degree perineal laceration during vaginal delivery: It is the first, and only, well-designed trial of antibiotic prophylaxis for prevention of complications after repair of a major perineal laceration. Among patients in the study, 8% who received antibiotics developed a wound complication, compared with 24% of patients who received placebo, a statistically and clinically significant difference.

Details of the study

Eighty-three women received placebo, and 64 received a single IV dose of either cefotetan (1 g) or cefoxitin (1 g) before their perineal laceration was repaired. Patients who were allergic to penicillin received clindamycin (900 mg). The primary endpoints of the study were gross disruption of the wound or purulent drainage from the wound site 2 weeks after delivery.

Forty patients (27%) did not return for their post-partum appointment. Of the remaining patients, four of 49 (8%) who received antibiotics developed a wound complication, compared with 14 of 58 (24%) of those who received placebo (p=.037).

 

Sequelae of major perineal laceration can be severe

Major perineal laceration occurs in approximately 2% to 20% of vaginal deliveries in the United States. The principal risk factors for third- and fourth-degree lacerations are nulliparity, midline episiotomy, and operative vaginal delivery, especially forceps extraction. Both types of laceration may lead to serious morbidity, such as prolonged pain, fecal incontinence, and perineal infection, including necrotizing fasciitis. These infections typically are polymicrobial, mixed aerobic–anaerobic. Moreover, fourth-degree lacerations may result in rectovaginal fistula if they are not repaired properly. This complication causes considerable debility and major social inconvenience for the patient.

Although the sample size was relatively small, this study clearly demonstrated that a single dose of extended-spectrum cephalosporin (cefotetan or cefoxitin) was highly effective in reducing the rate of perineal infection and perineal wound disruption. Whether a more limited-spectrum agent such as cefazolin would be as effective is not certain.

Diarrhea linked to Clostridium difficile emerges as a potent threat to pregnant women

Rouphael NG, O’Donnell JA, Bhatnagar J, et al. Clostridium difficile-associated diarrhea: an emerging threat to pregnant women. Am J Obstet Gynecol. 2008;198:635.e1–635.e6 [Classification of evidence – Level III].

This report describes 10 cases of severe Clostridium difficile-associated diarrhea (CDAD) in pregnant women during 2005 and 2006. CDAD usually affects elderly debilitated patients in hospitals and nursing homes. This report is of great concern because the affected patients were otherwise healthy, young, pregnant women. The observations are even more alarming because the mortality rate in this small series was 30% for both mothers and babies.

Details of the series

The women developed signs of severe CDAD 3 to 60 days after receiving antibiotics; the median was 5 days. CDAD was considered severe if the patient required hospitalization, ICU admission, or colectomy, or if she died. These cases occurred in California, Georgia, Oklahoma, and Pennsylvania and were reported to the Centers for Disease Control and Prevention (CDC).

Six women became ill before delivery, and four developed symptoms postpartum. The most common manifestations of infection were diarrhea, abdominal pain and distention, and fever. The peripheral white blood cell count was in the range of 11–72 × 10³/μL. In nine patients, the diagnosis was confirmed by a positive test for toxin A/B; seven of these patients also had visible pseudomembranes in the colon. One patient had a positive stool sample for C difficile ( FIGURE 2 ).

Six patients required admission to the ICU. Six developed toxic megacolon, and five required subtotal colectomy. Three had sepsis; three had acute renal failure; two had disseminated intravascular coagulation. Three patients died, and three had stillbirths. Two patients relapsed following treatment.

One patient had no treatment and died. The others received either metronidazole or vancomycin or a combination of the two. One of the patients who died received metronidazole, vancomycin, and cholestyramine.

FIGURE 2 Clostridium difficile

C difficile is a spore-forming, gram-positive anaerobic bacillus that is a common cause of antibiotic-associated diarrhea.

An epidemic strain appears

The incidence of C difficile infection in acute care US hospitals has increased to 84 for every 100,000 patients in recent years, about three times the rate of 31 for every 100,000 that was reported in 1996, as the authors note. Many of the most severe cases of CDAD are caused by a new epidemic strain of bacteria, termed North American Pulsed Field type 1 (NAP1) and PCR ribotype 027.

This new strain is characterized by three key virulence factors:

• increased production of toxins A and B
• resistance to fluoroquinolones
• production of binary toxin.

Toxins A and B bind to the surface of intestinal epithelial cells, stimulate tissue injury and inflammation, and, ultimately, lead to cell death. Binary toxin appears to act synergistically with toxins A and B to cause severe colitis.⁹

Metronidazole is no longer the treatment of choice for severe CDAD

Before 2000, treatment of CDAD with vancomycin or metronidazole was 97% to 98% effective.⁹ In recent years, however, a failure rate as high as 26% has been reported among patients who are treated with metronidazole.¹⁰ One prospective, randomized clinical trial demonstrated that, in patients who had severe CDAD, vancomycin, 125 mg four times daily, was superior to metronidazole, 250 mg four times daily (97% success rate vs 76%; p=.02).¹¹ The efficacy of the two drugs was comparable in treating milder cases of CDAD (98% for vancomycin, 90% for metronidazole; p=.36).

 

The authors report no financial relationships relevant to this article.

There’s a full moon tonight—and you’re the obstetrician on call. Not that you should expect any more funny business than usual. Despite stories of werewolves and other deviants coming out of the woodwork, there is no “full moon effect”—at least not one that can be documented. Nevertheless, chances are good that you will encounter at least one of the following psychiatric challenges as you end your day in the clinic and move on to an extended vigil:

• postpartum depression
  
• leaving against medical advice
  
• agitation
  
• antenatal illicit drug use
  
• denial or concealment of pregnancy.
  

In this article, we describe the management of these challenges and make recommendations to help increase your comfort level with patients who exhibit psychiatric problems. In some situations, our suggestions may help you manage the problem without a psychiatric consult.

Postpartum depression

CASE 1: Is it just the blues?

It is the end of your day in the clinic, and your last patient is a 30-year-old G3P3 who is 6 weeks postpartum. She describes repeated tearful episodes over the course of several weeks, decreased concentration, and poor appetite. She feels guilty because she is tired all the time and not bonding with her baby. She denies having suicidal or homicidal thoughts, or any hallucinations. She had expected her energy to return to normal over the first few postpartum weeks, but it has not. She is worried because she will soon be returning to work as a medical resident.

Does this patient have postpartum depression? Or is it another condition with overlapping symptoms?

If a mother tells you that she is suicidal or having thoughts of harming her child or others, she should be sent immediately to the nearest emergency department for psychiatric evaluation. Short of such a dramatic situation, how do you know when you should manage a patient’s depression on your own and when she should see a psychiatrist? Thorough assessment is the key.

Don’t mistake transient feelings for depression

Transient feelings of sadness, bereavement, and grief are not the same as depression, which must last 2 weeks or longer to confirm the diagnosis.

A quick mnemonic for symptoms of depression is SIG: E CAPS (as if writing a prescription for energy capsules) (TABLE 1).¹ This mnemonic helps remind you to assess the patient’s sleep, interest, guilt, energy, concentration, appetite, and psychomotor function, as well as identify any suicidal ideation.

It is important to assess a woman’s sleep and appetite in addition to mood. However, differences may be difficult to ascertain due to normal changes in the postpartum period. One useful question is whether the mother is able to sleep when the baby sleeps. If she isn’t, this wakefulness may be a symptom of depression.

The Edinburgh Postnatal Depression Scale is an easy, 10-question screening tool that is completed by the patient; it can be used both during pregnancy and postpartum. It is available on the Web at a number of sites, including www.fresno.ucsf.edu/pediatrics/downloads/edinburghscale.pdf.

TABLE 1

SIG: E CAPS—a mnemonic to assess for depression¹

Decreased (sometimes increased) Sleep
Decreased Interests
Feelings of Guilt
Decreased Energy
Decreased Concentration
Decreased (sometimes increased) Appetite
Psychomotor retardation, slowness
Suicidal thoughts, plans, or intent

Differential diagnosis

Besides postpartum depression, the differential diagnosis for altered mood in the postpartum period includes several entities.

Baby blues generally occurs quite soon after birth and resolves within 2 weeks. It involves crying, emotional lability, and irritability.² It occurs in around 50% to 75% of new mothers (compared with postpartum depression, which affects 10% to 20%).^3-5

Postpartum psychosis often involves the onset of psychotic symptoms within 1 week after delivery. The patient may exhibit both mood symptoms and psychosis. For example, she may believe that the baby is not hers or hear voices commanding her to kill the baby or warning her not to trust her healthcare providers.⁶ Postpartum psychosis has a prevalence of about 0.2%.^3-6

This psychosis can be organic in nature or can arise from a preexisting mood disorder or schizophrenia. Because treatment varies, depending on the cause, a thorough medical workup is needed.

 

Bipolar disorder may present as depression, but it also consists of manic periods of elevated, expansive, or irritable mood that last several days to weeks. Many symptoms appear to be the opposite of depression, such as increased energy and elevated self-esteem.^7,8

It is important to consider bipolar disorder in the differential diagnosis. If a woman who has unrecognized bipolar disorder is given an antidepressant, a manic state could be precipitated. Women who have bipolar disorder require different drugs than women who have depression only, and they should be evaluated by a psychiatrist, at least initially.

Start treatment as soon as possible

Once you confirm that the patient has postpartum depression—and not another psychiatric disorder—prescribing an antidepressant may be the next step. Keep in mind that these drugs take several weeks before their benefits are felt. Therefore, it is best to start an antidepressant before depression becomes severe. The mother may also benefit from psychotherapy.

The selective serotonin reuptake inhibitor sertraline (Zoloft) is a reasonable first choice in pregnancy and lactation when the depression is of new onset.^9,10 Start it gradually (e.g., 25 mg for sertraline, which can cause nausea if it is initiated too rapidly) and titrate it over time, if necessary. When there is comorbid anxiety, it sometimes is helpful to prescribe low dosages of lorazepam (Ativan, Temesta) on an as-needed basis, while the patient is waiting for the antidepressant to “kick in.” Also consider follow-up—do you plan to follow her frequently or refer her to psychiatry?

Remember to discuss the risks, benefits, side effects, and alternatives of antidepressant medication—and document that you have done so. In addition, discuss medication specifically in regard to lactation. Consultation with pediatrics is optimal.

Adjunctive or alternative options include psychotherapy, group therapy, and music therapy. Referral to a psychiatrist is warranted if the patient does not respond to the initial antidepressant agent.

Also be aware that untreated depression can become so severe that a woman can begin to experience psychosis, warranting rapid referral. Also refer any woman who reports a complex history of previous depression—unless the previous episode was easily controlled with a medicine safe for use during pregnancy and lactation.

If the patient is not lactating, a greater range of agents may be considered. (A full discussion of the risks and benefits of antidepressant use in pregnancy is outside the scope of this article. The interested reader is referred to an article on the subject by Wisner and colleagues.¹¹)

CASE 1 RESOLVED

A comprehensive discussion with the mother reveals that she is suffering from postpartum depression. No history of bipolar or psychotic symptoms is discovered. After discussing treatment options, you prescribe sertraline. Over the next 2 months, the patient’s symptoms improve, and she bonds with her infant and successfully returns to work. She is also referred to a psychologist to work through some underlying issues.

Leaving against medical advice

CASE 2: Patient threatens to leave the hospital

At midnight, you are paged to attend to a 32-year-old G1P0 at 27 weeks’ gestation who is threatening to leave against medical advice. She was admitted earlier in the day with uncontrolled gestational diabetes and is refusing her insulin.

How do you respond?

Use the relationship that you have established with this patient to the best of your ability. Make sure that you have explained fully, and in language she can easily comprehend, the reasons she needs to stay for treatment.

Don’t overlook the obvious, either: Why does she want to leave? Sometimes the reason makes sense (e.g., one mother wanted to leave to protect her daughter from an abusive husband). Other reasons may be related to psychosis, addiction, lack of sleep in the hospital, or a desire to smoke, drink, or use drugs. Can you convince her to postpone her decision until morning, when her physician will be available?

It is important to document in the medical record your explanations and her reasoning. Can she coherently verbalize an understanding of the consequences of her decision to leave, including the risks and implications to herself and the fetus?¹² Can she describe alternatives and the reasoning against them?

If she is able to do these things, and you find her thought processing and reasoning to be lucid, then she may have the capacity to leave against medical advice. Keep in mind that rational persons do have the right, constitutionally, to refuse treatment, even if doing so will lead to morbidity. (A Jehovah’s Witness who refuses treatment is the typical example.¹²) Contact the hospital’s attorney—tonight—and document that you did so. The attorney may recommend that the patient sign a letter stating that she recognizes the maternal and fetal risks of leaving.

 

Sometimes a patient must be held against her will

Some mothers lack the capacity to refuse treatment. They may be unable to verbalize an understanding of the situation and its risks. Their reasoning may be abnormal, with disorganized or delusional thinking, or both. The patient may be tangential or talk “in circles” rather than answer your questions.

Try to ascertain whether mood symptoms are contributing to her irrational thinking. For example, is her rationale for going home—“just to be with my husband because I don’t want to be alone”—due to her depression, despite the risk to herself and the fetus? Try to be flexible and creative. For example, you could call the husband and ask him to come to the hospital to sit with the patient.

Is the patient psychotic? For example, does she believe she has to leave now because the staff has been replaced by aliens who plan to kill her and her fetus? If so, you have the authority to continue her hospitalization—but contact the psychiatry department for medication recommendations. A urine toxicology screen would also be prudent.

If the patient is irrational and lacks the capacity to decide whether to stay or leave, document your conversation with her, as well as the reasoning behind your decision to intervene further. Other steps include:

• contacting the hospital’s attorney
  
• completing an emergency detention form
  
• calling security
  
• ensuring that the patient’s environment is safe for her and others (TABLE 2).¹³
  

If the patient is psychotic or delirious, look for organic causes and treat her to maintain her safety (see Case 3).

TABLE 2

5 steps to sound management of a patient who wants to leave
against medical advice

1. Ask the patient why she wants to leave now
2. Inform her of the risks to herself and to her fetus
3. Ask her to verbalize the risks to herself and to her fetus
4. Determine whether the patient’s request is rational If it is, call the hospital’s attorney at once; forms may need to be signed If it isn’t, and she is not convinced to stay, complete an emergency detention form; in addition, you may need to contact psychiatry, security, and the hospital’s attorney
5. Document the medical explanation and reasoning in the chart

CASE 2 RESOLVED

After building some rapport with the patient, you ask why she wants to leave right now. During this conversation, the patient reveals that she has not slept in three nights, and says she believes that the insulin is keeping her up. You are able to assure her that this is not the case and offer her something to help her sleep. She decides not to leave against medical advice.

Unexplained agitation

CASE 3: Patient becomes abusive

At 1 AM, you are called to the seventh floor, where a 20-year-old G2P1 at 26 weeks’ gestation is yelling at staff and hitting anyone who comes near. She was admitted earlier in the day for management of threatened abortion and a dilated cervix. She has no documented psychiatric history, but is flushed, disheveled, and hostile, accusing the staff of sabotaging her life, and is seen picking at imaginary things. You notify psychiatry, but no one is available.

What do you do?

Determining the origin of these symptoms will help determine the appropriate course of action. Among the possibilities are:

• drug intoxication or withdrawal
  
• delirium
  
• psychosis
  
• a chronic problem such as a personality disorder (TABLE 3).
  

Delirium is an acute disturbance of consciousness, with vacillating periods of clarity and confusion, often with agitation, and sometimes accompanied by visual hallucinations. Delirium has an organic rather than psychiatric cause; therefore, it is treated medically. Among the causes are fever, metabolic abnormality, and infection.

Psychosis means that a patient is out of touch with reality. A psychotic patient may experience delusions, auditory and visual hallucinations, and gross disorganization. Brief psychotic episodes usually last for 1 day to 1 month, with eventual recovery to premorbid functioning.⁷

Substances such as medications or illicit drugs also can induce psychosis. Major offenders include steroids and narcotic agents. Alternatively, sudden withdrawal of illicit substances (due to hospitalization) could manifest as delirium or psychosis.

Personality disorder. If the patient’s behavior is not new but a long-term problem, she may have a chronic personality disorder rather than acute illness. Personality problems involve pervasive response patterns and dysfunctional coping patterns that affect daily life. For example, a patient who has borderline personality disorder may have emotional instability presenting as intense episodic dysphoria or irritability. Such patients have a hard time empathizing with others, poor impulse control, and a desire for instant gratification. They may also misinterpret the behavior of other people and take offense easily as a result. Lacking stress-management skills, they regress to unhealthy defense mechanisms such as acting out, complaining, passive aggressiveness, and splitting of the staff (thinking that people are all good or all bad).

 

Dementia may also be on the differential diagnosis, but this chronic condition is unlikely in such a young patient (unless she were in the late stages of HIV/AIDS, for example). Dementia has a gradual onset and is irreversible.

TABLE 3

Some causes of agitation

Delirium fever, metabolic abnormality, or infection abrupt discontinuation of home narcotics/illicit substances
Psychosis substance-induced (administration of narcotics, steroids, or illicit drugs) abrupt discontinuation of home narcotics/illicit substances
Dementia HIV/AIDS encephalitis
Personality dysfunction poor coping skills exacerbated by the high stress of being hospitalized

Workup for the agitated patient

Assess vital signs and basic laboratory studies, particularly a complete blood count, thyroid testing, metabolic screens, glucose, serum chemistry panel, and urine toxicology, to rule out causes of delirium and detect any substances the patient may have used. Also consider that the patient may have initiated a new medication recently.

Imaging of the brain or chest or electroencephalography may be necessary, such as in the setting of infection or concerns regarding seizure activity.

Gather collateral information about the patient from her relatives, friends, and the support staff. Search her chart for recent contacts. Did she have a visitor or phone call that may have upset her? Explore whether she is having problems with her partner or family and friends. Also confirm that her agitated behavior is an acute change.

Investigate the patient’s paranoia. Why does she believe that the staff is against her? Does she believe they are trying to harm, kill, or poison her? Assess her reasoning to determine whether her behavior is psychotic or a personality problem.

Ask her about hallucinations, keeping in mind that hallucinations are different from illusions, in which a patient misinterprets what she sees. What are the voices saying to her?

Also ask about any suicidal or homicidal commands. If she acknowledges that she is hearing them, get a sitter for her immediately and make her environment safe so that she is unable to harm herself. Then contact the psychiatry department again.

How to intervene

Talk gently and quietly in an attempt to calm the situation. Try to make yourself “small”: Stand back and stay at the patient’s eye level, not in her personal space or towering over her.

Also, protect yourself. Don’t challenge her complaints immediately or you will alienate her. Medically evaluate and treat the cause of her agitation, and, if medications are necessary for psychosis or sedation, contact psychiatry for assistance.

CASE 3 RESOLVED

The patient does not respond to your attempts to reason and refuses to allow the nurses to check her vital signs. Security is called to stand by while her vital signs are reassessed. The nurses inform you that the patient’s family is in the waiting room. Though you find no documented history of substance use or abnormal labs, the family reports that the patient had a history of alcohol abuse but quit drinking about 3 days earlier. They also report that, before she quit, she drank approximately 25 oz of vodka and a sixpack of beer nightly. They deny knowledge of any other illicit drug use. Because her vital signs suggest alcohol withdrawal, you offer oral lorazepam and treat her according to the hospital’s alcohol withdrawal protocol. She recovers without any further complications and is referred to the chemical dependency service for evaluation.

Drug abuse during pregnancy

CASE 4: Patient skips prenatal care

It is 2 AM, and you are about to get some rest when you are paged by the emergency room about a 26-year-old G5P4, who is in active labor with no dates. You check the database and discover that her previous pregnancies were complicated by chronic substance abuse.

How do you respond?

You might feel frustrated and angry with this patient. Considering that you have not met her, these feelings would be based on previous contacts with patients who had a similar history. This is countertransference. We all experience it. It can be helpful or harmful, but you cannot control it unless you are aware of it. Pay attention to the anger, happiness, or pride that a patient triggers in you, and acknowledge that it is your issue.

Your frustration may also stem from personal feelings about mothers who repeatedly expose their fetuses to drugs and neglect prenatal care, as well as anxiety about what you are legally and ethically bound to do.

In Ferguson v City of Charleston, the Supreme Court found that drug testing of a pregnant woman for the purpose of criminal prosecution is a violation of Fourth Amendment rights.¹⁴ However, there have been cases in which a state prosecuted a woman for using an illegal substance during pregnancy.

 

These cases involved:

• child neglect¹⁵
  
• delivery of a stillborn fetus whose autopsy revealed traces of cocaine by-products¹⁶
  
• reckless endangerment after a newborn tested positive for cocaine.¹⁷
  

In 2006, a California appeals court determined that “the crime of reckless endangerment does not apply to a pregnant woman’s conduct with respect to the child she is carrying.”¹⁸ Other states have their own reporting criteria, as well as criteria for prosecution. It is important to know the reporting criteria for the state in which you practice.

What is drug abuse?

According to the 4th edition of the Diagnostic and Statistical Manual of Mental Health Disorders, it is a “maladaptive pattern of substance use manifested by recurrent and significant adverse consequences related to the repeated use of substances” within a 12-month period, or persistently.⁷ To meet criteria for substance dependence, in addition to the criteria just mentioned, the individual must be tolerant to the drug, experience withdrawal when the drug is cut back or stopped, continue to use the drug despite knowledge of its dangers, or all of the above. Mothers who match this description often lose custody of their child—sometimes to foster care, sometimes to other family members.^20,21

Some states use positive serum and urine toxicology as evidence to remove a child from the mother’s custody.¹⁹

It is important to attempt to build a doctor–patient relationship. You cannot solve the patient’s substance dependence problem in one night, but you can refer her to drug treatment. A urine toxicology screen can help you and the pediatricians know what the patient has been exposed to (TABLE 4).

TABLE 4

Commonly abused drugs and their potential effects

Drug	Withdrawal effects on mother	Drug effects on fetus or infant
Alcohol	Sweating, increased heart rate, hand tremor, nausea/vomiting, physical agitation, hallucination (tactile, visual, auditory), illusions, grand mal seizures25	Fetal alcohol syndrome. Withdrawal symptoms similar to those of the mother
Cocaine	Agitation, anxiety, anger, nausea/vomiting, muscle pain, disturbed sleep, depression, intense cravings for the drug, irritability25	Risk of abruptio placenta, small-for-gestational-age infant, microcephaly, congenital anomaly (cardiac and genitourinary abnormality, necrotizing enterocolitis), central nervous system stroke or hemorrhage. Withdrawal effects include hypertonia, jitteriness, and seizures.26
Crystal methamphetamine	Anxiety, psychotic reaction, intense hunger, irritability, restlessness, fatigue, depression, sleep disturbance, cravings25	Premature birth, abruptio placenta, small-for-gestational age, hypertonia, tremors, poor feeding, abnormal sleep patterns26
Marijuana	Irritability, anxiety, physical tension, decreased appetite and mood25	Irritability, increase in bodily motility, tremors, startles, poor habituation to visual stimuli, abnormal reflexes, symptoms similar to mild withdrawal27
Opioids (Heroin, methadone)	Dilated pupils, watery eyes, runny nose, diarrhea, nausea/vomiting, muscle cramps, piloerection, chills or profuse sweating, yawning, loss of appetite, tremor, jitteriness, panic, insomnia, stomach ache, irritability26	Risk of prematurity, small-for-gestational age, adult withdrawal symptoms, irritability, hypertonia, wakefulness, jitteriness, diarrhea, increased hiccups, yawning and sneezing, excessive sucking and seizures. Withdrawal effects occur earlier in heroin-exposed babies than in methadone-exposed infants.26

CASE 4 RESOLVED

After delivery, a test indicates that the newborn has been exposed to cocaine. The mother admits to cocaine use during pregnancy. She says she did not seek prenatal care because she was afraid of being prosecuted and sent to jail. A social work consult is requested, and the mother is referred to a substance abuse treatment program. State law requires the case to be reported to child protective services. Upon hospital discharge, the newborn is initially placed with the paternal grandmother.

Denial of pregnancy

CASE 5: Patient’s labor takes her by surprise

The night is nearing its end, but it isn’t over yet. At 5:30 AM, you are called to a precipitous delivery involving a 17-year-old who has had no prenatal care. She denies knowing that she was pregnant, and says she thought her labor pains were a bowel movement. Her parents were similarly unaware that their daughter was pregnant, and are threatening to disown her.

How do you defuse the situation?

In a study of women who denied or concealed pregnancy, patients presented to the hospital for various reasons.²² For example, one woman went to the ER because she was seizing and her workup revealed that she had eclampsia. A number of women did not even recognize when they were in labor. The infants born to these women are at risk for a poor neonatal outcome.^21,22

How can psychiatry help in such a case? By determining whether the patient denied her pregnancy—even to herself—or actively concealed it from others. Obviously, these circumstances have differing implications.

Denial is not a simple entity. It may involve a psychotic schizophrenic woman who is out of touch with the reality of her pregnancy; a woman who “affectively” denies her pregnancy, keeping the significance of her condition from herself and behaving as though she is not gravid (perhaps because she plans to give the baby up for adoption); or a woman who has pervasive denial and does not know that she is pregnant.^22,23 In contrast, a woman who conceals her pregnancy is quite aware that she is gravid but consciously hides the gestation from others, begging the question of what she had planned for the future.²²

 

Psychological issues abound, and may include a history of sexual and psychological trauma, an attempt to avoid religious prohibitions against unwed intercourse, anger at the father of the infant, and even homicidal urges toward the baby.²⁴ There may be more going on under the surface than “only” a failure to recognize the pregnancy, and the patient may need further mental health treatment.

Consider how well this young woman can be a mother. When she did not even recognize that she was pregnant for 9 months, how well will she be able to attend to her baby’s needs? Psychiatry can evaluate the patient to help determine her capacity for parenting and whether child protective services should be alerted. Of additional concern is the distress of the patient’s parents. Family support will be extremely important.

Be sure to conduct thorough contraceptive education and planning at the time of discharge because this patient is at risk for future denied or concealed pregnancies.²²

CASE 5 RESOLVED

The patient is seen by psychiatry. She has no major mental illness, but her denial appears to be related to problems with her boyfriend, her attempts to be the perfect daughter, and fear of being disowned. After the initial shock, the patient’s parents become more supportive and begin to bond with their new grandchild. The new mom is educated about birth control and agrees to follow up with a counselor and take parenting classes. The baby is discharged to his mother and grandparents.

The authors report no financial relationships relevant to this article.

There’s a full moon tonight—and you’re the obstetrician on call. Not that you should expect any more funny business than usual. Despite stories of werewolves and other deviants coming out of the woodwork, there is no “full moon effect”—at least not one that can be documented. Nevertheless, chances are good that you will encounter at least one of the following psychiatric challenges as you end your day in the clinic and move on to an extended vigil:

• postpartum depression
  
• leaving against medical advice
  
• agitation
  
• antenatal illicit drug use
  
• denial or concealment of pregnancy.
  

In this article, we describe the management of these challenges and make recommendations to help increase your comfort level with patients who exhibit psychiatric problems. In some situations, our suggestions may help you manage the problem without a psychiatric consult.

Postpartum depression

CASE 1: Is it just the blues?

It is the end of your day in the clinic, and your last patient is a 30-year-old G3P3 who is 6 weeks postpartum. She describes repeated tearful episodes over the course of several weeks, decreased concentration, and poor appetite. She feels guilty because she is tired all the time and not bonding with her baby. She denies having suicidal or homicidal thoughts, or any hallucinations. She had expected her energy to return to normal over the first few postpartum weeks, but it has not. She is worried because she will soon be returning to work as a medical resident.

Does this patient have postpartum depression? Or is it another condition with overlapping symptoms?

If a mother tells you that she is suicidal or having thoughts of harming her child or others, she should be sent immediately to the nearest emergency department for psychiatric evaluation. Short of such a dramatic situation, how do you know when you should manage a patient’s depression on your own and when she should see a psychiatrist? Thorough assessment is the key.

Don’t mistake transient feelings for depression

Transient feelings of sadness, bereavement, and grief are not the same as depression, which must last 2 weeks or longer to confirm the diagnosis.

A quick mnemonic for symptoms of depression is SIG: E CAPS (as if writing a prescription for energy capsules) (TABLE 1).¹ This mnemonic helps remind you to assess the patient’s sleep, interest, guilt, energy, concentration, appetite, and psychomotor function, as well as identify any suicidal ideation.

It is important to assess a woman’s sleep and appetite in addition to mood. However, differences may be difficult to ascertain due to normal changes in the postpartum period. One useful question is whether the mother is able to sleep when the baby sleeps. If she isn’t, this wakefulness may be a symptom of depression.

The Edinburgh Postnatal Depression Scale is an easy, 10-question screening tool that is completed by the patient; it can be used both during pregnancy and postpartum. It is available on the Web at a number of sites, including www.fresno.ucsf.edu/pediatrics/downloads/edinburghscale.pdf.

TABLE 1

SIG: E CAPS—a mnemonic to assess for depression¹

Decreased (sometimes increased) Sleep
Decreased Interests
Feelings of Guilt
Decreased Energy
Decreased Concentration
Decreased (sometimes increased) Appetite
Psychomotor retardation, slowness
Suicidal thoughts, plans, or intent

Differential diagnosis

Besides postpartum depression, the differential diagnosis for altered mood in the postpartum period includes several entities.

Baby blues generally occurs quite soon after birth and resolves within 2 weeks. It involves crying, emotional lability, and irritability.² It occurs in around 50% to 75% of new mothers (compared with postpartum depression, which affects 10% to 20%).^3-5

Postpartum psychosis often involves the onset of psychotic symptoms within 1 week after delivery. The patient may exhibit both mood symptoms and psychosis. For example, she may believe that the baby is not hers or hear voices commanding her to kill the baby or warning her not to trust her healthcare providers.⁶ Postpartum psychosis has a prevalence of about 0.2%.^3-6

This psychosis can be organic in nature or can arise from a preexisting mood disorder or schizophrenia. Because treatment varies, depending on the cause, a thorough medical workup is needed.

 

Bipolar disorder may present as depression, but it also consists of manic periods of elevated, expansive, or irritable mood that last several days to weeks. Many symptoms appear to be the opposite of depression, such as increased energy and elevated self-esteem.^7,8

It is important to consider bipolar disorder in the differential diagnosis. If a woman who has unrecognized bipolar disorder is given an antidepressant, a manic state could be precipitated. Women who have bipolar disorder require different drugs than women who have depression only, and they should be evaluated by a psychiatrist, at least initially.

Start treatment as soon as possible

Once you confirm that the patient has postpartum depression—and not another psychiatric disorder—prescribing an antidepressant may be the next step. Keep in mind that these drugs take several weeks before their benefits are felt. Therefore, it is best to start an antidepressant before depression becomes severe. The mother may also benefit from psychotherapy.

The selective serotonin reuptake inhibitor sertraline (Zoloft) is a reasonable first choice in pregnancy and lactation when the depression is of new onset.^9,10 Start it gradually (e.g., 25 mg for sertraline, which can cause nausea if it is initiated too rapidly) and titrate it over time, if necessary. When there is comorbid anxiety, it sometimes is helpful to prescribe low dosages of lorazepam (Ativan, Temesta) on an as-needed basis, while the patient is waiting for the antidepressant to “kick in.” Also consider follow-up—do you plan to follow her frequently or refer her to psychiatry?

Remember to discuss the risks, benefits, side effects, and alternatives of antidepressant medication—and document that you have done so. In addition, discuss medication specifically in regard to lactation. Consultation with pediatrics is optimal.

Adjunctive or alternative options include psychotherapy, group therapy, and music therapy. Referral to a psychiatrist is warranted if the patient does not respond to the initial antidepressant agent.

Also be aware that untreated depression can become so severe that a woman can begin to experience psychosis, warranting rapid referral. Also refer any woman who reports a complex history of previous depression—unless the previous episode was easily controlled with a medicine safe for use during pregnancy and lactation.

If the patient is not lactating, a greater range of agents may be considered. (A full discussion of the risks and benefits of antidepressant use in pregnancy is outside the scope of this article. The interested reader is referred to an article on the subject by Wisner and colleagues.¹¹)

CASE 1 RESOLVED

A comprehensive discussion with the mother reveals that she is suffering from postpartum depression. No history of bipolar or psychotic symptoms is discovered. After discussing treatment options, you prescribe sertraline. Over the next 2 months, the patient’s symptoms improve, and she bonds with her infant and successfully returns to work. She is also referred to a psychologist to work through some underlying issues.

Leaving against medical advice

CASE 2: Patient threatens to leave the hospital

At midnight, you are paged to attend to a 32-year-old G1P0 at 27 weeks’ gestation who is threatening to leave against medical advice. She was admitted earlier in the day with uncontrolled gestational diabetes and is refusing her insulin.

How do you respond?

Use the relationship that you have established with this patient to the best of your ability. Make sure that you have explained fully, and in language she can easily comprehend, the reasons she needs to stay for treatment.

Don’t overlook the obvious, either: Why does she want to leave? Sometimes the reason makes sense (e.g., one mother wanted to leave to protect her daughter from an abusive husband). Other reasons may be related to psychosis, addiction, lack of sleep in the hospital, or a desire to smoke, drink, or use drugs. Can you convince her to postpone her decision until morning, when her physician will be available?

It is important to document in the medical record your explanations and her reasoning. Can she coherently verbalize an understanding of the consequences of her decision to leave, including the risks and implications to herself and the fetus?¹² Can she describe alternatives and the reasoning against them?

If she is able to do these things, and you find her thought processing and reasoning to be lucid, then she may have the capacity to leave against medical advice. Keep in mind that rational persons do have the right, constitutionally, to refuse treatment, even if doing so will lead to morbidity. (A Jehovah’s Witness who refuses treatment is the typical example.¹²) Contact the hospital’s attorney—tonight—and document that you did so. The attorney may recommend that the patient sign a letter stating that she recognizes the maternal and fetal risks of leaving.

 

Sometimes a patient must be held against her will

Some mothers lack the capacity to refuse treatment. They may be unable to verbalize an understanding of the situation and its risks. Their reasoning may be abnormal, with disorganized or delusional thinking, or both. The patient may be tangential or talk “in circles” rather than answer your questions.

Try to ascertain whether mood symptoms are contributing to her irrational thinking. For example, is her rationale for going home—“just to be with my husband because I don’t want to be alone”—due to her depression, despite the risk to herself and the fetus? Try to be flexible and creative. For example, you could call the husband and ask him to come to the hospital to sit with the patient.

Is the patient psychotic? For example, does she believe she has to leave now because the staff has been replaced by aliens who plan to kill her and her fetus? If so, you have the authority to continue her hospitalization—but contact the psychiatry department for medication recommendations. A urine toxicology screen would also be prudent.

If the patient is irrational and lacks the capacity to decide whether to stay or leave, document your conversation with her, as well as the reasoning behind your decision to intervene further. Other steps include:

• contacting the hospital’s attorney
  
• completing an emergency detention form
  
• calling security
  
• ensuring that the patient’s environment is safe for her and others (TABLE 2).¹³
  

If the patient is psychotic or delirious, look for organic causes and treat her to maintain her safety (see Case 3).

TABLE 2

5 steps to sound management of a patient who wants to leave
against medical advice

1. Ask the patient why she wants to leave now
2. Inform her of the risks to herself and to her fetus
3. Ask her to verbalize the risks to herself and to her fetus
4. Determine whether the patient’s request is rational If it is, call the hospital’s attorney at once; forms may need to be signed If it isn’t, and she is not convinced to stay, complete an emergency detention form; in addition, you may need to contact psychiatry, security, and the hospital’s attorney
5. Document the medical explanation and reasoning in the chart

CASE 2 RESOLVED

After building some rapport with the patient, you ask why she wants to leave right now. During this conversation, the patient reveals that she has not slept in three nights, and says she believes that the insulin is keeping her up. You are able to assure her that this is not the case and offer her something to help her sleep. She decides not to leave against medical advice.

Unexplained agitation

CASE 3: Patient becomes abusive

At 1 AM, you are called to the seventh floor, where a 20-year-old G2P1 at 26 weeks’ gestation is yelling at staff and hitting anyone who comes near. She was admitted earlier in the day for management of threatened abortion and a dilated cervix. She has no documented psychiatric history, but is flushed, disheveled, and hostile, accusing the staff of sabotaging her life, and is seen picking at imaginary things. You notify psychiatry, but no one is available.

What do you do?

Determining the origin of these symptoms will help determine the appropriate course of action. Among the possibilities are:

• drug intoxication or withdrawal
  
• delirium
  
• psychosis
  
• a chronic problem such as a personality disorder (TABLE 3).
  

Delirium is an acute disturbance of consciousness, with vacillating periods of clarity and confusion, often with agitation, and sometimes accompanied by visual hallucinations. Delirium has an organic rather than psychiatric cause; therefore, it is treated medically. Among the causes are fever, metabolic abnormality, and infection.

Psychosis means that a patient is out of touch with reality. A psychotic patient may experience delusions, auditory and visual hallucinations, and gross disorganization. Brief psychotic episodes usually last for 1 day to 1 month, with eventual recovery to premorbid functioning.⁷

Substances such as medications or illicit drugs also can induce psychosis. Major offenders include steroids and narcotic agents. Alternatively, sudden withdrawal of illicit substances (due to hospitalization) could manifest as delirium or psychosis.

Personality disorder. If the patient’s behavior is not new but a long-term problem, she may have a chronic personality disorder rather than acute illness. Personality problems involve pervasive response patterns and dysfunctional coping patterns that affect daily life. For example, a patient who has borderline personality disorder may have emotional instability presenting as intense episodic dysphoria or irritability. Such patients have a hard time empathizing with others, poor impulse control, and a desire for instant gratification. They may also misinterpret the behavior of other people and take offense easily as a result. Lacking stress-management skills, they regress to unhealthy defense mechanisms such as acting out, complaining, passive aggressiveness, and splitting of the staff (thinking that people are all good or all bad).

 

Dementia may also be on the differential diagnosis, but this chronic condition is unlikely in such a young patient (unless she were in the late stages of HIV/AIDS, for example). Dementia has a gradual onset and is irreversible.

TABLE 3

Some causes of agitation

Delirium fever, metabolic abnormality, or infection abrupt discontinuation of home narcotics/illicit substances
Psychosis substance-induced (administration of narcotics, steroids, or illicit drugs) abrupt discontinuation of home narcotics/illicit substances
Dementia HIV/AIDS encephalitis
Personality dysfunction poor coping skills exacerbated by the high stress of being hospitalized

Workup for the agitated patient

Assess vital signs and basic laboratory studies, particularly a complete blood count, thyroid testing, metabolic screens, glucose, serum chemistry panel, and urine toxicology, to rule out causes of delirium and detect any substances the patient may have used. Also consider that the patient may have initiated a new medication recently.

Imaging of the brain or chest or electroencephalography may be necessary, such as in the setting of infection or concerns regarding seizure activity.

Gather collateral information about the patient from her relatives, friends, and the support staff. Search her chart for recent contacts. Did she have a visitor or phone call that may have upset her? Explore whether she is having problems with her partner or family and friends. Also confirm that her agitated behavior is an acute change.

Investigate the patient’s paranoia. Why does she believe that the staff is against her? Does she believe they are trying to harm, kill, or poison her? Assess her reasoning to determine whether her behavior is psychotic or a personality problem.

Ask her about hallucinations, keeping in mind that hallucinations are different from illusions, in which a patient misinterprets what she sees. What are the voices saying to her?

Also ask about any suicidal or homicidal commands. If she acknowledges that she is hearing them, get a sitter for her immediately and make her environment safe so that she is unable to harm herself. Then contact the psychiatry department again.

How to intervene

Talk gently and quietly in an attempt to calm the situation. Try to make yourself “small”: Stand back and stay at the patient’s eye level, not in her personal space or towering over her.

Also, protect yourself. Don’t challenge her complaints immediately or you will alienate her. Medically evaluate and treat the cause of her agitation, and, if medications are necessary for psychosis or sedation, contact psychiatry for assistance.

CASE 3 RESOLVED

The patient does not respond to your attempts to reason and refuses to allow the nurses to check her vital signs. Security is called to stand by while her vital signs are reassessed. The nurses inform you that the patient’s family is in the waiting room. Though you find no documented history of substance use or abnormal labs, the family reports that the patient had a history of alcohol abuse but quit drinking about 3 days earlier. They also report that, before she quit, she drank approximately 25 oz of vodka and a sixpack of beer nightly. They deny knowledge of any other illicit drug use. Because her vital signs suggest alcohol withdrawal, you offer oral lorazepam and treat her according to the hospital’s alcohol withdrawal protocol. She recovers without any further complications and is referred to the chemical dependency service for evaluation.

Drug abuse during pregnancy

CASE 4: Patient skips prenatal care

It is 2 AM, and you are about to get some rest when you are paged by the emergency room about a 26-year-old G5P4, who is in active labor with no dates. You check the database and discover that her previous pregnancies were complicated by chronic substance abuse.

How do you respond?

You might feel frustrated and angry with this patient. Considering that you have not met her, these feelings would be based on previous contacts with patients who had a similar history. This is countertransference. We all experience it. It can be helpful or harmful, but you cannot control it unless you are aware of it. Pay attention to the anger, happiness, or pride that a patient triggers in you, and acknowledge that it is your issue.

Your frustration may also stem from personal feelings about mothers who repeatedly expose their fetuses to drugs and neglect prenatal care, as well as anxiety about what you are legally and ethically bound to do.

In Ferguson v City of Charleston, the Supreme Court found that drug testing of a pregnant woman for the purpose of criminal prosecution is a violation of Fourth Amendment rights.¹⁴ However, there have been cases in which a state prosecuted a woman for using an illegal substance during pregnancy.

 

These cases involved:

• child neglect¹⁵
  
• delivery of a stillborn fetus whose autopsy revealed traces of cocaine by-products¹⁶
  
• reckless endangerment after a newborn tested positive for cocaine.¹⁷
  

In 2006, a California appeals court determined that “the crime of reckless endangerment does not apply to a pregnant woman’s conduct with respect to the child she is carrying.”¹⁸ Other states have their own reporting criteria, as well as criteria for prosecution. It is important to know the reporting criteria for the state in which you practice.

What is drug abuse?

According to the 4th edition of the Diagnostic and Statistical Manual of Mental Health Disorders, it is a “maladaptive pattern of substance use manifested by recurrent and significant adverse consequences related to the repeated use of substances” within a 12-month period, or persistently.⁷ To meet criteria for substance dependence, in addition to the criteria just mentioned, the individual must be tolerant to the drug, experience withdrawal when the drug is cut back or stopped, continue to use the drug despite knowledge of its dangers, or all of the above. Mothers who match this description often lose custody of their child—sometimes to foster care, sometimes to other family members.^20,21

Some states use positive serum and urine toxicology as evidence to remove a child from the mother’s custody.¹⁹

It is important to attempt to build a doctor–patient relationship. You cannot solve the patient’s substance dependence problem in one night, but you can refer her to drug treatment. A urine toxicology screen can help you and the pediatricians know what the patient has been exposed to (TABLE 4).

TABLE 4

Commonly abused drugs and their potential effects

Drug	Withdrawal effects on mother	Drug effects on fetus or infant
Alcohol	Sweating, increased heart rate, hand tremor, nausea/vomiting, physical agitation, hallucination (tactile, visual, auditory), illusions, grand mal seizures25	Fetal alcohol syndrome. Withdrawal symptoms similar to those of the mother
Cocaine	Agitation, anxiety, anger, nausea/vomiting, muscle pain, disturbed sleep, depression, intense cravings for the drug, irritability25	Risk of abruptio placenta, small-for-gestational-age infant, microcephaly, congenital anomaly (cardiac and genitourinary abnormality, necrotizing enterocolitis), central nervous system stroke or hemorrhage. Withdrawal effects include hypertonia, jitteriness, and seizures.26
Crystal methamphetamine	Anxiety, psychotic reaction, intense hunger, irritability, restlessness, fatigue, depression, sleep disturbance, cravings25	Premature birth, abruptio placenta, small-for-gestational age, hypertonia, tremors, poor feeding, abnormal sleep patterns26
Marijuana	Irritability, anxiety, physical tension, decreased appetite and mood25	Irritability, increase in bodily motility, tremors, startles, poor habituation to visual stimuli, abnormal reflexes, symptoms similar to mild withdrawal27
Opioids (Heroin, methadone)	Dilated pupils, watery eyes, runny nose, diarrhea, nausea/vomiting, muscle cramps, piloerection, chills or profuse sweating, yawning, loss of appetite, tremor, jitteriness, panic, insomnia, stomach ache, irritability26	Risk of prematurity, small-for-gestational age, adult withdrawal symptoms, irritability, hypertonia, wakefulness, jitteriness, diarrhea, increased hiccups, yawning and sneezing, excessive sucking and seizures. Withdrawal effects occur earlier in heroin-exposed babies than in methadone-exposed infants.26

CASE 4 RESOLVED

After delivery, a test indicates that the newborn has been exposed to cocaine. The mother admits to cocaine use during pregnancy. She says she did not seek prenatal care because she was afraid of being prosecuted and sent to jail. A social work consult is requested, and the mother is referred to a substance abuse treatment program. State law requires the case to be reported to child protective services. Upon hospital discharge, the newborn is initially placed with the paternal grandmother.

Denial of pregnancy

CASE 5: Patient’s labor takes her by surprise

The night is nearing its end, but it isn’t over yet. At 5:30 AM, you are called to a precipitous delivery involving a 17-year-old who has had no prenatal care. She denies knowing that she was pregnant, and says she thought her labor pains were a bowel movement. Her parents were similarly unaware that their daughter was pregnant, and are threatening to disown her.

How do you defuse the situation?

In a study of women who denied or concealed pregnancy, patients presented to the hospital for various reasons.²² For example, one woman went to the ER because she was seizing and her workup revealed that she had eclampsia. A number of women did not even recognize when they were in labor. The infants born to these women are at risk for a poor neonatal outcome.^21,22

How can psychiatry help in such a case? By determining whether the patient denied her pregnancy—even to herself—or actively concealed it from others. Obviously, these circumstances have differing implications.

Denial is not a simple entity. It may involve a psychotic schizophrenic woman who is out of touch with the reality of her pregnancy; a woman who “affectively” denies her pregnancy, keeping the significance of her condition from herself and behaving as though she is not gravid (perhaps because she plans to give the baby up for adoption); or a woman who has pervasive denial and does not know that she is pregnant.^22,23 In contrast, a woman who conceals her pregnancy is quite aware that she is gravid but consciously hides the gestation from others, begging the question of what she had planned for the future.²²

 

Psychological issues abound, and may include a history of sexual and psychological trauma, an attempt to avoid religious prohibitions against unwed intercourse, anger at the father of the infant, and even homicidal urges toward the baby.²⁴ There may be more going on under the surface than “only” a failure to recognize the pregnancy, and the patient may need further mental health treatment.

Consider how well this young woman can be a mother. When she did not even recognize that she was pregnant for 9 months, how well will she be able to attend to her baby’s needs? Psychiatry can evaluate the patient to help determine her capacity for parenting and whether child protective services should be alerted. Of additional concern is the distress of the patient’s parents. Family support will be extremely important.

Be sure to conduct thorough contraceptive education and planning at the time of discharge because this patient is at risk for future denied or concealed pregnancies.²²

CASE 5 RESOLVED

The patient is seen by psychiatry. She has no major mental illness, but her denial appears to be related to problems with her boyfriend, her attempts to be the perfect daughter, and fear of being disowned. After the initial shock, the patient’s parents become more supportive and begin to bond with their new grandchild. The new mom is educated about birth control and agrees to follow up with a counselor and take parenting classes. The baby is discharged to his mother and grandparents.

The authors report no financial relationships relevant to this article.

There’s a full moon tonight—and you’re the obstetrician on call. Not that you should expect any more funny business than usual. Despite stories of werewolves and other deviants coming out of the woodwork, there is no “full moon effect”—at least not one that can be documented. Nevertheless, chances are good that you will encounter at least one of the following psychiatric challenges as you end your day in the clinic and move on to an extended vigil:

• postpartum depression
  
• leaving against medical advice
  
• agitation
  
• antenatal illicit drug use
  
• denial or concealment of pregnancy.
  

In this article, we describe the management of these challenges and make recommendations to help increase your comfort level with patients who exhibit psychiatric problems. In some situations, our suggestions may help you manage the problem without a psychiatric consult.

Postpartum depression

CASE 1: Is it just the blues?

It is the end of your day in the clinic, and your last patient is a 30-year-old G3P3 who is 6 weeks postpartum. She describes repeated tearful episodes over the course of several weeks, decreased concentration, and poor appetite. She feels guilty because she is tired all the time and not bonding with her baby. She denies having suicidal or homicidal thoughts, or any hallucinations. She had expected her energy to return to normal over the first few postpartum weeks, but it has not. She is worried because she will soon be returning to work as a medical resident.

Does this patient have postpartum depression? Or is it another condition with overlapping symptoms?

If a mother tells you that she is suicidal or having thoughts of harming her child or others, she should be sent immediately to the nearest emergency department for psychiatric evaluation. Short of such a dramatic situation, how do you know when you should manage a patient’s depression on your own and when she should see a psychiatrist? Thorough assessment is the key.

Don’t mistake transient feelings for depression

Transient feelings of sadness, bereavement, and grief are not the same as depression, which must last 2 weeks or longer to confirm the diagnosis.

A quick mnemonic for symptoms of depression is SIG: E CAPS (as if writing a prescription for energy capsules) (TABLE 1).¹ This mnemonic helps remind you to assess the patient’s sleep, interest, guilt, energy, concentration, appetite, and psychomotor function, as well as identify any suicidal ideation.

It is important to assess a woman’s sleep and appetite in addition to mood. However, differences may be difficult to ascertain due to normal changes in the postpartum period. One useful question is whether the mother is able to sleep when the baby sleeps. If she isn’t, this wakefulness may be a symptom of depression.

The Edinburgh Postnatal Depression Scale is an easy, 10-question screening tool that is completed by the patient; it can be used both during pregnancy and postpartum. It is available on the Web at a number of sites, including www.fresno.ucsf.edu/pediatrics/downloads/edinburghscale.pdf.

TABLE 1

SIG: E CAPS—a mnemonic to assess for depression¹

Decreased (sometimes increased) Sleep
Decreased Interests
Feelings of Guilt
Decreased Energy
Decreased Concentration
Decreased (sometimes increased) Appetite
Psychomotor retardation, slowness
Suicidal thoughts, plans, or intent

Differential diagnosis

Besides postpartum depression, the differential diagnosis for altered mood in the postpartum period includes several entities.

Baby blues generally occurs quite soon after birth and resolves within 2 weeks. It involves crying, emotional lability, and irritability.² It occurs in around 50% to 75% of new mothers (compared with postpartum depression, which affects 10% to 20%).^3-5

Postpartum psychosis often involves the onset of psychotic symptoms within 1 week after delivery. The patient may exhibit both mood symptoms and psychosis. For example, she may believe that the baby is not hers or hear voices commanding her to kill the baby or warning her not to trust her healthcare providers.⁶ Postpartum psychosis has a prevalence of about 0.2%.^3-6

This psychosis can be organic in nature or can arise from a preexisting mood disorder or schizophrenia. Because treatment varies, depending on the cause, a thorough medical workup is needed.

 

Bipolar disorder may present as depression, but it also consists of manic periods of elevated, expansive, or irritable mood that last several days to weeks. Many symptoms appear to be the opposite of depression, such as increased energy and elevated self-esteem.^7,8

It is important to consider bipolar disorder in the differential diagnosis. If a woman who has unrecognized bipolar disorder is given an antidepressant, a manic state could be precipitated. Women who have bipolar disorder require different drugs than women who have depression only, and they should be evaluated by a psychiatrist, at least initially.

Start treatment as soon as possible

Once you confirm that the patient has postpartum depression—and not another psychiatric disorder—prescribing an antidepressant may be the next step. Keep in mind that these drugs take several weeks before their benefits are felt. Therefore, it is best to start an antidepressant before depression becomes severe. The mother may also benefit from psychotherapy.

The selective serotonin reuptake inhibitor sertraline (Zoloft) is a reasonable first choice in pregnancy and lactation when the depression is of new onset.^9,10 Start it gradually (e.g., 25 mg for sertraline, which can cause nausea if it is initiated too rapidly) and titrate it over time, if necessary. When there is comorbid anxiety, it sometimes is helpful to prescribe low dosages of lorazepam (Ativan, Temesta) on an as-needed basis, while the patient is waiting for the antidepressant to “kick in.” Also consider follow-up—do you plan to follow her frequently or refer her to psychiatry?

Remember to discuss the risks, benefits, side effects, and alternatives of antidepressant medication—and document that you have done so. In addition, discuss medication specifically in regard to lactation. Consultation with pediatrics is optimal.

Adjunctive or alternative options include psychotherapy, group therapy, and music therapy. Referral to a psychiatrist is warranted if the patient does not respond to the initial antidepressant agent.

Also be aware that untreated depression can become so severe that a woman can begin to experience psychosis, warranting rapid referral. Also refer any woman who reports a complex history of previous depression—unless the previous episode was easily controlled with a medicine safe for use during pregnancy and lactation.

If the patient is not lactating, a greater range of agents may be considered. (A full discussion of the risks and benefits of antidepressant use in pregnancy is outside the scope of this article. The interested reader is referred to an article on the subject by Wisner and colleagues.¹¹)

CASE 1 RESOLVED

A comprehensive discussion with the mother reveals that she is suffering from postpartum depression. No history of bipolar or psychotic symptoms is discovered. After discussing treatment options, you prescribe sertraline. Over the next 2 months, the patient’s symptoms improve, and she bonds with her infant and successfully returns to work. She is also referred to a psychologist to work through some underlying issues.

Leaving against medical advice

CASE 2: Patient threatens to leave the hospital

At midnight, you are paged to attend to a 32-year-old G1P0 at 27 weeks’ gestation who is threatening to leave against medical advice. She was admitted earlier in the day with uncontrolled gestational diabetes and is refusing her insulin.

How do you respond?

Use the relationship that you have established with this patient to the best of your ability. Make sure that you have explained fully, and in language she can easily comprehend, the reasons she needs to stay for treatment.

Don’t overlook the obvious, either: Why does she want to leave? Sometimes the reason makes sense (e.g., one mother wanted to leave to protect her daughter from an abusive husband). Other reasons may be related to psychosis, addiction, lack of sleep in the hospital, or a desire to smoke, drink, or use drugs. Can you convince her to postpone her decision until morning, when her physician will be available?

It is important to document in the medical record your explanations and her reasoning. Can she coherently verbalize an understanding of the consequences of her decision to leave, including the risks and implications to herself and the fetus?¹² Can she describe alternatives and the reasoning against them?

If she is able to do these things, and you find her thought processing and reasoning to be lucid, then she may have the capacity to leave against medical advice. Keep in mind that rational persons do have the right, constitutionally, to refuse treatment, even if doing so will lead to morbidity. (A Jehovah’s Witness who refuses treatment is the typical example.¹²) Contact the hospital’s attorney—tonight—and document that you did so. The attorney may recommend that the patient sign a letter stating that she recognizes the maternal and fetal risks of leaving.

 

Sometimes a patient must be held against her will

Some mothers lack the capacity to refuse treatment. They may be unable to verbalize an understanding of the situation and its risks. Their reasoning may be abnormal, with disorganized or delusional thinking, or both. The patient may be tangential or talk “in circles” rather than answer your questions.

Try to ascertain whether mood symptoms are contributing to her irrational thinking. For example, is her rationale for going home—“just to be with my husband because I don’t want to be alone”—due to her depression, despite the risk to herself and the fetus? Try to be flexible and creative. For example, you could call the husband and ask him to come to the hospital to sit with the patient.

Is the patient psychotic? For example, does she believe she has to leave now because the staff has been replaced by aliens who plan to kill her and her fetus? If so, you have the authority to continue her hospitalization—but contact the psychiatry department for medication recommendations. A urine toxicology screen would also be prudent.

If the patient is irrational and lacks the capacity to decide whether to stay or leave, document your conversation with her, as well as the reasoning behind your decision to intervene further. Other steps include:

• contacting the hospital’s attorney
  
• completing an emergency detention form
  
• calling security
  
• ensuring that the patient’s environment is safe for her and others (TABLE 2).¹³
  

If the patient is psychotic or delirious, look for organic causes and treat her to maintain her safety (see Case 3).

TABLE 2

5 steps to sound management of a patient who wants to leave
against medical advice

1. Ask the patient why she wants to leave now
2. Inform her of the risks to herself and to her fetus
3. Ask her to verbalize the risks to herself and to her fetus
4. Determine whether the patient’s request is rational If it is, call the hospital’s attorney at once; forms may need to be signed If it isn’t, and she is not convinced to stay, complete an emergency detention form; in addition, you may need to contact psychiatry, security, and the hospital’s attorney
5. Document the medical explanation and reasoning in the chart

CASE 2 RESOLVED

After building some rapport with the patient, you ask why she wants to leave right now. During this conversation, the patient reveals that she has not slept in three nights, and says she believes that the insulin is keeping her up. You are able to assure her that this is not the case and offer her something to help her sleep. She decides not to leave against medical advice.

Unexplained agitation

CASE 3: Patient becomes abusive

At 1 AM, you are called to the seventh floor, where a 20-year-old G2P1 at 26 weeks’ gestation is yelling at staff and hitting anyone who comes near. She was admitted earlier in the day for management of threatened abortion and a dilated cervix. She has no documented psychiatric history, but is flushed, disheveled, and hostile, accusing the staff of sabotaging her life, and is seen picking at imaginary things. You notify psychiatry, but no one is available.

What do you do?

Determining the origin of these symptoms will help determine the appropriate course of action. Among the possibilities are:

• drug intoxication or withdrawal
  
• delirium
  
• psychosis
  
• a chronic problem such as a personality disorder (TABLE 3).
  

Delirium is an acute disturbance of consciousness, with vacillating periods of clarity and confusion, often with agitation, and sometimes accompanied by visual hallucinations. Delirium has an organic rather than psychiatric cause; therefore, it is treated medically. Among the causes are fever, metabolic abnormality, and infection.

Psychosis means that a patient is out of touch with reality. A psychotic patient may experience delusions, auditory and visual hallucinations, and gross disorganization. Brief psychotic episodes usually last for 1 day to 1 month, with eventual recovery to premorbid functioning.⁷

Substances such as medications or illicit drugs also can induce psychosis. Major offenders include steroids and narcotic agents. Alternatively, sudden withdrawal of illicit substances (due to hospitalization) could manifest as delirium or psychosis.

Personality disorder. If the patient’s behavior is not new but a long-term problem, she may have a chronic personality disorder rather than acute illness. Personality problems involve pervasive response patterns and dysfunctional coping patterns that affect daily life. For example, a patient who has borderline personality disorder may have emotional instability presenting as intense episodic dysphoria or irritability. Such patients have a hard time empathizing with others, poor impulse control, and a desire for instant gratification. They may also misinterpret the behavior of other people and take offense easily as a result. Lacking stress-management skills, they regress to unhealthy defense mechanisms such as acting out, complaining, passive aggressiveness, and splitting of the staff (thinking that people are all good or all bad).

 

Dementia may also be on the differential diagnosis, but this chronic condition is unlikely in such a young patient (unless she were in the late stages of HIV/AIDS, for example). Dementia has a gradual onset and is irreversible.

TABLE 3

Some causes of agitation

Delirium fever, metabolic abnormality, or infection abrupt discontinuation of home narcotics/illicit substances
Psychosis substance-induced (administration of narcotics, steroids, or illicit drugs) abrupt discontinuation of home narcotics/illicit substances
Dementia HIV/AIDS encephalitis
Personality dysfunction poor coping skills exacerbated by the high stress of being hospitalized

Workup for the agitated patient

Assess vital signs and basic laboratory studies, particularly a complete blood count, thyroid testing, metabolic screens, glucose, serum chemistry panel, and urine toxicology, to rule out causes of delirium and detect any substances the patient may have used. Also consider that the patient may have initiated a new medication recently.

Imaging of the brain or chest or electroencephalography may be necessary, such as in the setting of infection or concerns regarding seizure activity.

Gather collateral information about the patient from her relatives, friends, and the support staff. Search her chart for recent contacts. Did she have a visitor or phone call that may have upset her? Explore whether she is having problems with her partner or family and friends. Also confirm that her agitated behavior is an acute change.

Investigate the patient’s paranoia. Why does she believe that the staff is against her? Does she believe they are trying to harm, kill, or poison her? Assess her reasoning to determine whether her behavior is psychotic or a personality problem.

Ask her about hallucinations, keeping in mind that hallucinations are different from illusions, in which a patient misinterprets what she sees. What are the voices saying to her?

Also ask about any suicidal or homicidal commands. If she acknowledges that she is hearing them, get a sitter for her immediately and make her environment safe so that she is unable to harm herself. Then contact the psychiatry department again.

How to intervene

Talk gently and quietly in an attempt to calm the situation. Try to make yourself “small”: Stand back and stay at the patient’s eye level, not in her personal space or towering over her.

Also, protect yourself. Don’t challenge her complaints immediately or you will alienate her. Medically evaluate and treat the cause of her agitation, and, if medications are necessary for psychosis or sedation, contact psychiatry for assistance.

CASE 3 RESOLVED

The patient does not respond to your attempts to reason and refuses to allow the nurses to check her vital signs. Security is called to stand by while her vital signs are reassessed. The nurses inform you that the patient’s family is in the waiting room. Though you find no documented history of substance use or abnormal labs, the family reports that the patient had a history of alcohol abuse but quit drinking about 3 days earlier. They also report that, before she quit, she drank approximately 25 oz of vodka and a sixpack of beer nightly. They deny knowledge of any other illicit drug use. Because her vital signs suggest alcohol withdrawal, you offer oral lorazepam and treat her according to the hospital’s alcohol withdrawal protocol. She recovers without any further complications and is referred to the chemical dependency service for evaluation.

Drug abuse during pregnancy

CASE 4: Patient skips prenatal care

It is 2 AM, and you are about to get some rest when you are paged by the emergency room about a 26-year-old G5P4, who is in active labor with no dates. You check the database and discover that her previous pregnancies were complicated by chronic substance abuse.

How do you respond?

You might feel frustrated and angry with this patient. Considering that you have not met her, these feelings would be based on previous contacts with patients who had a similar history. This is countertransference. We all experience it. It can be helpful or harmful, but you cannot control it unless you are aware of it. Pay attention to the anger, happiness, or pride that a patient triggers in you, and acknowledge that it is your issue.

Your frustration may also stem from personal feelings about mothers who repeatedly expose their fetuses to drugs and neglect prenatal care, as well as anxiety about what you are legally and ethically bound to do.

In Ferguson v City of Charleston, the Supreme Court found that drug testing of a pregnant woman for the purpose of criminal prosecution is a violation of Fourth Amendment rights.¹⁴ However, there have been cases in which a state prosecuted a woman for using an illegal substance during pregnancy.

 

These cases involved:

• child neglect¹⁵
  
• delivery of a stillborn fetus whose autopsy revealed traces of cocaine by-products¹⁶
  
• reckless endangerment after a newborn tested positive for cocaine.¹⁷
  

In 2006, a California appeals court determined that “the crime of reckless endangerment does not apply to a pregnant woman’s conduct with respect to the child she is carrying.”¹⁸ Other states have their own reporting criteria, as well as criteria for prosecution. It is important to know the reporting criteria for the state in which you practice.

What is drug abuse?

According to the 4th edition of the Diagnostic and Statistical Manual of Mental Health Disorders, it is a “maladaptive pattern of substance use manifested by recurrent and significant adverse consequences related to the repeated use of substances” within a 12-month period, or persistently.⁷ To meet criteria for substance dependence, in addition to the criteria just mentioned, the individual must be tolerant to the drug, experience withdrawal when the drug is cut back or stopped, continue to use the drug despite knowledge of its dangers, or all of the above. Mothers who match this description often lose custody of their child—sometimes to foster care, sometimes to other family members.^20,21

Some states use positive serum and urine toxicology as evidence to remove a child from the mother’s custody.¹⁹

It is important to attempt to build a doctor–patient relationship. You cannot solve the patient’s substance dependence problem in one night, but you can refer her to drug treatment. A urine toxicology screen can help you and the pediatricians know what the patient has been exposed to (TABLE 4).

TABLE 4

Commonly abused drugs and their potential effects

Drug	Withdrawal effects on mother	Drug effects on fetus or infant
Alcohol	Sweating, increased heart rate, hand tremor, nausea/vomiting, physical agitation, hallucination (tactile, visual, auditory), illusions, grand mal seizures25	Fetal alcohol syndrome. Withdrawal symptoms similar to those of the mother
Cocaine	Agitation, anxiety, anger, nausea/vomiting, muscle pain, disturbed sleep, depression, intense cravings for the drug, irritability25	Risk of abruptio placenta, small-for-gestational-age infant, microcephaly, congenital anomaly (cardiac and genitourinary abnormality, necrotizing enterocolitis), central nervous system stroke or hemorrhage. Withdrawal effects include hypertonia, jitteriness, and seizures.26
Crystal methamphetamine	Anxiety, psychotic reaction, intense hunger, irritability, restlessness, fatigue, depression, sleep disturbance, cravings25	Premature birth, abruptio placenta, small-for-gestational age, hypertonia, tremors, poor feeding, abnormal sleep patterns26
Marijuana	Irritability, anxiety, physical tension, decreased appetite and mood25	Irritability, increase in bodily motility, tremors, startles, poor habituation to visual stimuli, abnormal reflexes, symptoms similar to mild withdrawal27
Opioids (Heroin, methadone)	Dilated pupils, watery eyes, runny nose, diarrhea, nausea/vomiting, muscle cramps, piloerection, chills or profuse sweating, yawning, loss of appetite, tremor, jitteriness, panic, insomnia, stomach ache, irritability26	Risk of prematurity, small-for-gestational age, adult withdrawal symptoms, irritability, hypertonia, wakefulness, jitteriness, diarrhea, increased hiccups, yawning and sneezing, excessive sucking and seizures. Withdrawal effects occur earlier in heroin-exposed babies than in methadone-exposed infants.26

CASE 4 RESOLVED

After delivery, a test indicates that the newborn has been exposed to cocaine. The mother admits to cocaine use during pregnancy. She says she did not seek prenatal care because she was afraid of being prosecuted and sent to jail. A social work consult is requested, and the mother is referred to a substance abuse treatment program. State law requires the case to be reported to child protective services. Upon hospital discharge, the newborn is initially placed with the paternal grandmother.

Denial of pregnancy

CASE 5: Patient’s labor takes her by surprise

The night is nearing its end, but it isn’t over yet. At 5:30 AM, you are called to a precipitous delivery involving a 17-year-old who has had no prenatal care. She denies knowing that she was pregnant, and says she thought her labor pains were a bowel movement. Her parents were similarly unaware that their daughter was pregnant, and are threatening to disown her.

How do you defuse the situation?

In a study of women who denied or concealed pregnancy, patients presented to the hospital for various reasons.²² For example, one woman went to the ER because she was seizing and her workup revealed that she had eclampsia. A number of women did not even recognize when they were in labor. The infants born to these women are at risk for a poor neonatal outcome.^21,22

How can psychiatry help in such a case? By determining whether the patient denied her pregnancy—even to herself—or actively concealed it from others. Obviously, these circumstances have differing implications.

Denial is not a simple entity. It may involve a psychotic schizophrenic woman who is out of touch with the reality of her pregnancy; a woman who “affectively” denies her pregnancy, keeping the significance of her condition from herself and behaving as though she is not gravid (perhaps because she plans to give the baby up for adoption); or a woman who has pervasive denial and does not know that she is pregnant.^22,23 In contrast, a woman who conceals her pregnancy is quite aware that she is gravid but consciously hides the gestation from others, begging the question of what she had planned for the future.²²

 

Psychological issues abound, and may include a history of sexual and psychological trauma, an attempt to avoid religious prohibitions against unwed intercourse, anger at the father of the infant, and even homicidal urges toward the baby.²⁴ There may be more going on under the surface than “only” a failure to recognize the pregnancy, and the patient may need further mental health treatment.

Consider how well this young woman can be a mother. When she did not even recognize that she was pregnant for 9 months, how well will she be able to attend to her baby’s needs? Psychiatry can evaluate the patient to help determine her capacity for parenting and whether child protective services should be alerted. Of additional concern is the distress of the patient’s parents. Family support will be extremely important.

Be sure to conduct thorough contraceptive education and planning at the time of discharge because this patient is at risk for future denied or concealed pregnancies.²²

CASE 5 RESOLVED

The patient is seen by psychiatry. She has no major mental illness, but her denial appears to be related to problems with her boyfriend, her attempts to be the perfect daughter, and fear of being disowned. After the initial shock, the patient’s parents become more supportive and begin to bond with their new grandchild. The new mom is educated about birth control and agrees to follow up with a counselor and take parenting classes. The baby is discharged to his mother and grandparents.

To most Americans, the sight of a soldier returning from Operation Enduring Freedom (OEF) or Operation Iraqi Freedom (OIF) and being reunited with his or her family epitomizes a happy ending. After all, parents, spouses, and children, having sent their loved ones to serve in Afghanistan or Iraq, now have their heroes returned safely to them. Not every family has been so fortunate, and each reunion is a small victory, a moment to reflect on what has been lost since 2001—and to be grateful for what has not.

But sometimes the battle continues when the troops come home. It may be a very different battle—but then again, the conflicts in Iraq and Afghanistan represent a very different kind of war. What our soldiers have experienced in theatre, through extended and multiple deployments, often leaves them with lingering, not-so-obvious injuries. The effects of these psychological and emotional wounds, if they are not properly healed, impact not only the soldiers but also their families.

The Department of Veterans Affairs (VA) has been developing programs and services to meet soldiers’ physical and mental health needs, but not every OEF/OIF veteran is going to have ready access to a top-notch VA facility. Health care providers in non-VA settings may represent the only contact some soldiers and their families will have with the health care system.

“I think providers have the burden here, because they’re the ones that are going to be on the front lines, seeing these families,” says Peggy Anne Fisher McNulty, DrPH, CPNP, CFNP, RN, an Assistant Professor in the University of Hawaii at Manoa School of Nursing and Dental Hygiene, who served with the US Navy Nurse Corps for more than 30 years. “I think it’s going to be their mission to open that door and get families the help they need.”

Invisible Wounds
Last year, the RAND Corporation’s Center for Military Health Policy Research issued a report outlining the effects the current conflicts have had on soldiers. A confidential survey of almost 2,000 returned veterans indicated that nearly 19% met criteria for either posttraumatic stress disorder (PTSD) or depression, and nearly 20% reported experiencing a probable traumatic brain injury during deployment. An earlier report from the VA’s Special Committee on PTSD suggested that up to 20% of OEF/OIF veterans are “at risk for significant symptoms short of full diagnosis but severe enough to cause significant functional impairment.”

Beyond potential clinical diagnoses, soldiers’ lives in theatre are just much different from civilian life. Deployment has been described as a year-long adrenaline rush, filled with stressors, and soldiers are trained to have a battle mindset and focus on the mission.

“That frame of mind is hard to transition back from,” says Master Sergeant Christopher Pugh of the Community-Based Warrior Transition Unit of Massachusetts, an Iraq veteran who was preparing to redeploy when Clinician Reviews spoke with him. “For most soldiers who come off the plane, they’re not focused on battle mind or potential problems. They just want to get through the process and go home to their loved ones if possible. And that’s usually when the problems start arising.”

Readjustment issues can include difficulty dealing with crowds, loss of patience with certain individuals, and a lingering sense of urgency that others don’t feel. “You feel like if you need to get something done, it has to be done right away,” Pugh explains, “whereas it’s not as important to anyone else.”

But if left unaddressed, any of these underlying stressors could eventually manifest in the form of domestic, substance abuse, or gambling problems. According to a study published in JAMA last year, nearly 12% of soldiers report problems with alcohol on their postdeployment health assessment forms. Unpublished data from a study of OEF/OIF veterans referred for behavioral health assessment (as cited in a -report by the Iraq and Afghanistan Veterans of America) indicated that more than half of those who were currently or recently separated from their partner reported “conflicts involving shouting, pushing, or shoving.” Another 22% of those surveyed reported concerns that their children “did not act warmly” toward them or “were afraid” of them.

Even more distressing is the possibility of suicide; the rate among active-duty veterans is on track to surpass the demographically adjusted civilian rate, but statistics on veterans who have completed their service are more difficult to obtain. These issues negatively impact not only the soldier but also his or her family. 

“Soldiers aren’t getting the help they need, so the families are suffering,” says McNulty, who is conducting research on the effects of reunification. Her data, which she is preparing for publication, indicate that spouses were most likely to take steps toward divorce within three months of their soldier’s return home. Other high-risk factors, such as contemplation of suicide or use of prescription medications for stress, remained high throughout the study, which ended 12 months after the soldier’s return.

 

“Spouses seem to be groping for help,” McNulty observes, “whereas the soldiers aren’t, yet. And you can’t heal the whole family without both people getting the proper help.”

Opening the Door in Primary Care
Whether primary care providers are in a position to help families heal may depend on their training and available resources. But they can play a very important role in identifying at-risk soldiers and families and encouraging them to seek help.

“Primary care is a great place to catch people, because I notice veterans will come in if they need to get their hearing or their back checked out,” says Elizabeth Price, LICSW, a social worker at the ENRM-VA Hospital in Bedford, Massachusetts. “Those are very concrete issues that people need to get addressed. But while they’re there, we also have the opportunity to ask, ‘How are you doing? That must have been a really stressful year you just had; how are things going?’”

Price, McNulty, and Pugh all emphasize the importance of normalizing the transition process. “We very much try to pre-sent it as, ‘This can be a really hard process for a lot of people. We just want to see how you’re doing with it. A lot of people do fine; have you noticed anything challenging or different since you’ve been back?’” Price explains. “Leave it pretty open-ended. 

“I think if families knew that it wasn’t a stigma for them to be hurting,” McNulty says, “that’s a good message that I don’t know that they get.”

Performing a thorough assessment and asking the right questions, such as those related to sleep, may help to identify a soldier or family member whose needs run deeper than their presenting complaint. “The basic questions are [often] enough to alert providers that maybe there’s something else going on that a soldier might need to talk to somebody about,” Pugh says.

Price points out, too, that “there is no set timeline” on how long it will take soldiers and families to readjust. With that in mind, she says it might be helpful to arrange for more frequent follow-up visits rather than waiting for the next annual physical to roll around. “If we can engage folks that way,” she says, “that might be another opportunity to keep an eye on things.”

Preventing a New “Don’t Ask, Don’t Tell”
Clinicians may need to ask the sensitive questions related to stress, depression, and suicidal thoughts. “If we don’t ask, we miss that person,” McNulty says. “If you just ask, they can deny it—but maybe the second time they come to see you, they’ll say, ‘You know what? I am depressed. And what you said last time, I’ve thought about it and yes, I’ve thought of suicide.’ You have to open that door or you won’t get them to trust you enough. It’s a fine line when you’re a provider, but if you develop a rapport and trust, you can save families.”

The VA has established a Web site for returning veterans (www.oefoif.va.gov) that provides information about available services and benefits. Soldiers who are not ready to pursue mental health care or counseling may be more willing to connect with peers; Pugh says community-based organizations such as the American Legion and the Veterans of Foreign Wars may be good additional resources for them. But everyone has an opportunity to make a difference.

“I had a pretty good doc—I say he was pretty good, because he actually caught something that I wasn’t fully aware of myself,” Pugh says. “So, even when you’re presented with complaints, they may not seem what they really are until you do a little more digging. I know you say everyone should do that, but not everyone does.”

“A lot of times, patients come in wanting that help, but they’re going to say they have a stomachache,” McNulty adds. “Sure, you can treat their stomachache, but why are they having a stomachache?

“You have to play detective with these families and find out what’s triggering these symptoms. Maybe it’s not the stomachache. Maybe we don’t have to run all these tests a million times. Maybe we just have to find out what’s really going on emotionally.”

The views expressed in this article are those of the individuals and do not necessarily reflect those of the US government or any of its agencies.

To most Americans, the sight of a soldier returning from Operation Enduring Freedom (OEF) or Operation Iraqi Freedom (OIF) and being reunited with his or her family epitomizes a happy ending. After all, parents, spouses, and children, having sent their loved ones to serve in Afghanistan or Iraq, now have their heroes returned safely to them. Not every family has been so fortunate, and each reunion is a small victory, a moment to reflect on what has been lost since 2001—and to be grateful for what has not.

But sometimes the battle continues when the troops come home. It may be a very different battle—but then again, the conflicts in Iraq and Afghanistan represent a very different kind of war. What our soldiers have experienced in theatre, through extended and multiple deployments, often leaves them with lingering, not-so-obvious injuries. The effects of these psychological and emotional wounds, if they are not properly healed, impact not only the soldiers but also their families.

The Department of Veterans Affairs (VA) has been developing programs and services to meet soldiers’ physical and mental health needs, but not every OEF/OIF veteran is going to have ready access to a top-notch VA facility. Health care providers in non-VA settings may represent the only contact some soldiers and their families will have with the health care system.

“I think providers have the burden here, because they’re the ones that are going to be on the front lines, seeing these families,” says Peggy Anne Fisher McNulty, DrPH, CPNP, CFNP, RN, an Assistant Professor in the University of Hawaii at Manoa School of Nursing and Dental Hygiene, who served with the US Navy Nurse Corps for more than 30 years. “I think it’s going to be their mission to open that door and get families the help they need.”

Invisible Wounds
Last year, the RAND Corporation’s Center for Military Health Policy Research issued a report outlining the effects the current conflicts have had on soldiers. A confidential survey of almost 2,000 returned veterans indicated that nearly 19% met criteria for either posttraumatic stress disorder (PTSD) or depression, and nearly 20% reported experiencing a probable traumatic brain injury during deployment. An earlier report from the VA’s Special Committee on PTSD suggested that up to 20% of OEF/OIF veterans are “at risk for significant symptoms short of full diagnosis but severe enough to cause significant functional impairment.”

Beyond potential clinical diagnoses, soldiers’ lives in theatre are just much different from civilian life. Deployment has been described as a year-long adrenaline rush, filled with stressors, and soldiers are trained to have a battle mindset and focus on the mission.

“That frame of mind is hard to transition back from,” says Master Sergeant Christopher Pugh of the Community-Based Warrior Transition Unit of Massachusetts, an Iraq veteran who was preparing to redeploy when Clinician Reviews spoke with him. “For most soldiers who come off the plane, they’re not focused on battle mind or potential problems. They just want to get through the process and go home to their loved ones if possible. And that’s usually when the problems start arising.”

Readjustment issues can include difficulty dealing with crowds, loss of patience with certain individuals, and a lingering sense of urgency that others don’t feel. “You feel like if you need to get something done, it has to be done right away,” Pugh explains, “whereas it’s not as important to anyone else.”

But if left unaddressed, any of these underlying stressors could eventually manifest in the form of domestic, substance abuse, or gambling problems. According to a study published in JAMA last year, nearly 12% of soldiers report problems with alcohol on their postdeployment health assessment forms. Unpublished data from a study of OEF/OIF veterans referred for behavioral health assessment (as cited in a -report by the Iraq and Afghanistan Veterans of America) indicated that more than half of those who were currently or recently separated from their partner reported “conflicts involving shouting, pushing, or shoving.” Another 22% of those surveyed reported concerns that their children “did not act warmly” toward them or “were afraid” of them.

Even more distressing is the possibility of suicide; the rate among active-duty veterans is on track to surpass the demographically adjusted civilian rate, but statistics on veterans who have completed their service are more difficult to obtain. These issues negatively impact not only the soldier but also his or her family. 

“Soldiers aren’t getting the help they need, so the families are suffering,” says McNulty, who is conducting research on the effects of reunification. Her data, which she is preparing for publication, indicate that spouses were most likely to take steps toward divorce within three months of their soldier’s return home. Other high-risk factors, such as contemplation of suicide or use of prescription medications for stress, remained high throughout the study, which ended 12 months after the soldier’s return.

 

“Spouses seem to be groping for help,” McNulty observes, “whereas the soldiers aren’t, yet. And you can’t heal the whole family without both people getting the proper help.”

Opening the Door in Primary Care
Whether primary care providers are in a position to help families heal may depend on their training and available resources. But they can play a very important role in identifying at-risk soldiers and families and encouraging them to seek help.

“Primary care is a great place to catch people, because I notice veterans will come in if they need to get their hearing or their back checked out,” says Elizabeth Price, LICSW, a social worker at the ENRM-VA Hospital in Bedford, Massachusetts. “Those are very concrete issues that people need to get addressed. But while they’re there, we also have the opportunity to ask, ‘How are you doing? That must have been a really stressful year you just had; how are things going?’”

Price, McNulty, and Pugh all emphasize the importance of normalizing the transition process. “We very much try to pre-sent it as, ‘This can be a really hard process for a lot of people. We just want to see how you’re doing with it. A lot of people do fine; have you noticed anything challenging or different since you’ve been back?’” Price explains. “Leave it pretty open-ended. 

“I think if families knew that it wasn’t a stigma for them to be hurting,” McNulty says, “that’s a good message that I don’t know that they get.”

Performing a thorough assessment and asking the right questions, such as those related to sleep, may help to identify a soldier or family member whose needs run deeper than their presenting complaint. “The basic questions are [often] enough to alert providers that maybe there’s something else going on that a soldier might need to talk to somebody about,” Pugh says.

Price points out, too, that “there is no set timeline” on how long it will take soldiers and families to readjust. With that in mind, she says it might be helpful to arrange for more frequent follow-up visits rather than waiting for the next annual physical to roll around. “If we can engage folks that way,” she says, “that might be another opportunity to keep an eye on things.”

Preventing a New “Don’t Ask, Don’t Tell”
Clinicians may need to ask the sensitive questions related to stress, depression, and suicidal thoughts. “If we don’t ask, we miss that person,” McNulty says. “If you just ask, they can deny it—but maybe the second time they come to see you, they’ll say, ‘You know what? I am depressed. And what you said last time, I’ve thought about it and yes, I’ve thought of suicide.’ You have to open that door or you won’t get them to trust you enough. It’s a fine line when you’re a provider, but if you develop a rapport and trust, you can save families.”

The VA has established a Web site for returning veterans (www.oefoif.va.gov) that provides information about available services and benefits. Soldiers who are not ready to pursue mental health care or counseling may be more willing to connect with peers; Pugh says community-based organizations such as the American Legion and the Veterans of Foreign Wars may be good additional resources for them. But everyone has an opportunity to make a difference.

“I had a pretty good doc—I say he was pretty good, because he actually caught something that I wasn’t fully aware of myself,” Pugh says. “So, even when you’re presented with complaints, they may not seem what they really are until you do a little more digging. I know you say everyone should do that, but not everyone does.”

“A lot of times, patients come in wanting that help, but they’re going to say they have a stomachache,” McNulty adds. “Sure, you can treat their stomachache, but why are they having a stomachache?

“You have to play detective with these families and find out what’s triggering these symptoms. Maybe it’s not the stomachache. Maybe we don’t have to run all these tests a million times. Maybe we just have to find out what’s really going on emotionally.”

The views expressed in this article are those of the individuals and do not necessarily reflect those of the US government or any of its agencies.

To most Americans, the sight of a soldier returning from Operation Enduring Freedom (OEF) or Operation Iraqi Freedom (OIF) and being reunited with his or her family epitomizes a happy ending. After all, parents, spouses, and children, having sent their loved ones to serve in Afghanistan or Iraq, now have their heroes returned safely to them. Not every family has been so fortunate, and each reunion is a small victory, a moment to reflect on what has been lost since 2001—and to be grateful for what has not.

But sometimes the battle continues when the troops come home. It may be a very different battle—but then again, the conflicts in Iraq and Afghanistan represent a very different kind of war. What our soldiers have experienced in theatre, through extended and multiple deployments, often leaves them with lingering, not-so-obvious injuries. The effects of these psychological and emotional wounds, if they are not properly healed, impact not only the soldiers but also their families.

The Department of Veterans Affairs (VA) has been developing programs and services to meet soldiers’ physical and mental health needs, but not every OEF/OIF veteran is going to have ready access to a top-notch VA facility. Health care providers in non-VA settings may represent the only contact some soldiers and their families will have with the health care system.

“I think providers have the burden here, because they’re the ones that are going to be on the front lines, seeing these families,” says Peggy Anne Fisher McNulty, DrPH, CPNP, CFNP, RN, an Assistant Professor in the University of Hawaii at Manoa School of Nursing and Dental Hygiene, who served with the US Navy Nurse Corps for more than 30 years. “I think it’s going to be their mission to open that door and get families the help they need.”

Invisible Wounds
Last year, the RAND Corporation’s Center for Military Health Policy Research issued a report outlining the effects the current conflicts have had on soldiers. A confidential survey of almost 2,000 returned veterans indicated that nearly 19% met criteria for either posttraumatic stress disorder (PTSD) or depression, and nearly 20% reported experiencing a probable traumatic brain injury during deployment. An earlier report from the VA’s Special Committee on PTSD suggested that up to 20% of OEF/OIF veterans are “at risk for significant symptoms short of full diagnosis but severe enough to cause significant functional impairment.”

Beyond potential clinical diagnoses, soldiers’ lives in theatre are just much different from civilian life. Deployment has been described as a year-long adrenaline rush, filled with stressors, and soldiers are trained to have a battle mindset and focus on the mission.

“That frame of mind is hard to transition back from,” says Master Sergeant Christopher Pugh of the Community-Based Warrior Transition Unit of Massachusetts, an Iraq veteran who was preparing to redeploy when Clinician Reviews spoke with him. “For most soldiers who come off the plane, they’re not focused on battle mind or potential problems. They just want to get through the process and go home to their loved ones if possible. And that’s usually when the problems start arising.”

Readjustment issues can include difficulty dealing with crowds, loss of patience with certain individuals, and a lingering sense of urgency that others don’t feel. “You feel like if you need to get something done, it has to be done right away,” Pugh explains, “whereas it’s not as important to anyone else.”

But if left unaddressed, any of these underlying stressors could eventually manifest in the form of domestic, substance abuse, or gambling problems. According to a study published in JAMA last year, nearly 12% of soldiers report problems with alcohol on their postdeployment health assessment forms. Unpublished data from a study of OEF/OIF veterans referred for behavioral health assessment (as cited in a -report by the Iraq and Afghanistan Veterans of America) indicated that more than half of those who were currently or recently separated from their partner reported “conflicts involving shouting, pushing, or shoving.” Another 22% of those surveyed reported concerns that their children “did not act warmly” toward them or “were afraid” of them.

Even more distressing is the possibility of suicide; the rate among active-duty veterans is on track to surpass the demographically adjusted civilian rate, but statistics on veterans who have completed their service are more difficult to obtain. These issues negatively impact not only the soldier but also his or her family. 

“Soldiers aren’t getting the help they need, so the families are suffering,” says McNulty, who is conducting research on the effects of reunification. Her data, which she is preparing for publication, indicate that spouses were most likely to take steps toward divorce within three months of their soldier’s return home. Other high-risk factors, such as contemplation of suicide or use of prescription medications for stress, remained high throughout the study, which ended 12 months after the soldier’s return.

 

“Spouses seem to be groping for help,” McNulty observes, “whereas the soldiers aren’t, yet. And you can’t heal the whole family without both people getting the proper help.”

Opening the Door in Primary Care
Whether primary care providers are in a position to help families heal may depend on their training and available resources. But they can play a very important role in identifying at-risk soldiers and families and encouraging them to seek help.

“Primary care is a great place to catch people, because I notice veterans will come in if they need to get their hearing or their back checked out,” says Elizabeth Price, LICSW, a social worker at the ENRM-VA Hospital in Bedford, Massachusetts. “Those are very concrete issues that people need to get addressed. But while they’re there, we also have the opportunity to ask, ‘How are you doing? That must have been a really stressful year you just had; how are things going?’”

Price, McNulty, and Pugh all emphasize the importance of normalizing the transition process. “We very much try to pre-sent it as, ‘This can be a really hard process for a lot of people. We just want to see how you’re doing with it. A lot of people do fine; have you noticed anything challenging or different since you’ve been back?’” Price explains. “Leave it pretty open-ended. 

“I think if families knew that it wasn’t a stigma for them to be hurting,” McNulty says, “that’s a good message that I don’t know that they get.”

Performing a thorough assessment and asking the right questions, such as those related to sleep, may help to identify a soldier or family member whose needs run deeper than their presenting complaint. “The basic questions are [often] enough to alert providers that maybe there’s something else going on that a soldier might need to talk to somebody about,” Pugh says.

Price points out, too, that “there is no set timeline” on how long it will take soldiers and families to readjust. With that in mind, she says it might be helpful to arrange for more frequent follow-up visits rather than waiting for the next annual physical to roll around. “If we can engage folks that way,” she says, “that might be another opportunity to keep an eye on things.”

Preventing a New “Don’t Ask, Don’t Tell”
Clinicians may need to ask the sensitive questions related to stress, depression, and suicidal thoughts. “If we don’t ask, we miss that person,” McNulty says. “If you just ask, they can deny it—but maybe the second time they come to see you, they’ll say, ‘You know what? I am depressed. And what you said last time, I’ve thought about it and yes, I’ve thought of suicide.’ You have to open that door or you won’t get them to trust you enough. It’s a fine line when you’re a provider, but if you develop a rapport and trust, you can save families.”

The VA has established a Web site for returning veterans (www.oefoif.va.gov) that provides information about available services and benefits. Soldiers who are not ready to pursue mental health care or counseling may be more willing to connect with peers; Pugh says community-based organizations such as the American Legion and the Veterans of Foreign Wars may be good additional resources for them. But everyone has an opportunity to make a difference.

“I had a pretty good doc—I say he was pretty good, because he actually caught something that I wasn’t fully aware of myself,” Pugh says. “So, even when you’re presented with complaints, they may not seem what they really are until you do a little more digging. I know you say everyone should do that, but not everyone does.”

“A lot of times, patients come in wanting that help, but they’re going to say they have a stomachache,” McNulty adds. “Sure, you can treat their stomachache, but why are they having a stomachache?

“You have to play detective with these families and find out what’s triggering these symptoms. Maybe it’s not the stomachache. Maybe we don’t have to run all these tests a million times. Maybe we just have to find out what’s really going on emotionally.”

The views expressed in this article are those of the individuals and do not necessarily reflect those of the US government or any of its agencies.