Key clinical point: Regular tea consumption shows a weak inverse association with risk for gastric cancer.

Major finding: Regular vs. nonregular tea drinkers had a significantly lower risk for gastric cancer (pooled odds ratio [OR] 0.91; 95% CI 0.85-0.97). Compared with nonregular tea drinkers, there was no difference in risk for gastric cancer in regular tea drinkers who consumed 1 to <2, 2 to <3, ≥3 cups (P_trend = .27). A lower risk was observed in studies from China, Japan, and Iran (OR 0.62; 95% CI 0.48-0.81) and from China and Japan (OR 0.67; 95% CI  0.49-0.91).

Study details: A pooled analysis of 34 studies including 13,121 patients with gastric cancer and 31,420 control individuals from the StoP Project (a consortium of epidemiological studies on gastric cancer) dataset.

Disclosures: This study was supported by Associazione Italiana per la Ricerca sul Cancro and Italian League for the Fight Against Cancer. The authors declared no competing interests.

Source: Martimianaki G et al. Tea consumption and gastric cancer: A pooled analysis from the Stomach cancer Pooling (StoP) Project consortium. Br J Cancer. 2022 (May 24). Doi: 10.1038/s41416-022-01856-w

Key clinical point: Regular tea consumption shows a weak inverse association with risk for gastric cancer.

Major finding: Regular vs. nonregular tea drinkers had a significantly lower risk for gastric cancer (pooled odds ratio [OR] 0.91; 95% CI 0.85-0.97). Compared with nonregular tea drinkers, there was no difference in risk for gastric cancer in regular tea drinkers who consumed 1 to <2, 2 to <3, ≥3 cups (P_trend = .27). A lower risk was observed in studies from China, Japan, and Iran (OR 0.62; 95% CI 0.48-0.81) and from China and Japan (OR 0.67; 95% CI  0.49-0.91).

Study details: A pooled analysis of 34 studies including 13,121 patients with gastric cancer and 31,420 control individuals from the StoP Project (a consortium of epidemiological studies on gastric cancer) dataset.

Disclosures: This study was supported by Associazione Italiana per la Ricerca sul Cancro and Italian League for the Fight Against Cancer. The authors declared no competing interests.

Source: Martimianaki G et al. Tea consumption and gastric cancer: A pooled analysis from the Stomach cancer Pooling (StoP) Project consortium. Br J Cancer. 2022 (May 24). Doi: 10.1038/s41416-022-01856-w

Key clinical point: Regular tea consumption shows a weak inverse association with risk for gastric cancer.

Major finding: Regular vs. nonregular tea drinkers had a significantly lower risk for gastric cancer (pooled odds ratio [OR] 0.91; 95% CI 0.85-0.97). Compared with nonregular tea drinkers, there was no difference in risk for gastric cancer in regular tea drinkers who consumed 1 to <2, 2 to <3, ≥3 cups (P_trend = .27). A lower risk was observed in studies from China, Japan, and Iran (OR 0.62; 95% CI 0.48-0.81) and from China and Japan (OR 0.67; 95% CI  0.49-0.91).

Study details: A pooled analysis of 34 studies including 13,121 patients with gastric cancer and 31,420 control individuals from the StoP Project (a consortium of epidemiological studies on gastric cancer) dataset.

Disclosures: This study was supported by Associazione Italiana per la Ricerca sul Cancro and Italian League for the Fight Against Cancer. The authors declared no competing interests.

Source: Martimianaki G et al. Tea consumption and gastric cancer: A pooled analysis from the Stomach cancer Pooling (StoP) Project consortium. Br J Cancer. 2022 (May 24). Doi: 10.1038/s41416-022-01856-w

Key clinical point: High tumor mutational burden (TMB) is associated with clinical outcomes with pembrolizumab with or without chemotherapy in patients with gastric/gastroesophageal junction adenocarcinoma.

Major finding: In patients with high TMB, pembrolizumab vs. chemotherapy significantly improved the objective response rate (ORR; 55.6% vs. 41.2%), progression-free survival (PFS; hazard ratio [HR] 0.52), and overall survival (OS; HR 0.34). Similarly, pembrolizumab plus chemotherapy vs. chemotherapy improved ORR (73.3% vs. 41.2%), PFS (HR 0.62), and OS (HR 0.54) in patients with high TMB.

Study details: This prespecified exploratory analysis of phase 3 KEYNOTE-062 study included patients with gastric cancer who were randomly assigned (1:1:1) to receive pembrolizumab, pembrolizumab plus chemotherapy, or placebo plus chemotherapy.

Disclosures: This study was funded by Merck Sharp and Dohme LLC. The authors declared receiving grants, personal or advisory fees, or nonfinancial support. Some authors declared owing stocks or being cofounders or employees in various companies.

Source: Lee K-W et al. Association of tumor mutational burden with efficacy of pembrolizumab ± chemotherapy as first-line therapy for gastric cancer in the phase III KEYNOTE-062 study. Clin Cancer Res. 2022 (Jun 3). Doi: 10.1158/1078-0432.CCR-22-0121

Key clinical point: High tumor mutational burden (TMB) is associated with clinical outcomes with pembrolizumab with or without chemotherapy in patients with gastric/gastroesophageal junction adenocarcinoma.

Major finding: In patients with high TMB, pembrolizumab vs. chemotherapy significantly improved the objective response rate (ORR; 55.6% vs. 41.2%), progression-free survival (PFS; hazard ratio [HR] 0.52), and overall survival (OS; HR 0.34). Similarly, pembrolizumab plus chemotherapy vs. chemotherapy improved ORR (73.3% vs. 41.2%), PFS (HR 0.62), and OS (HR 0.54) in patients with high TMB.

Study details: This prespecified exploratory analysis of phase 3 KEYNOTE-062 study included patients with gastric cancer who were randomly assigned (1:1:1) to receive pembrolizumab, pembrolizumab plus chemotherapy, or placebo plus chemotherapy.

Disclosures: This study was funded by Merck Sharp and Dohme LLC. The authors declared receiving grants, personal or advisory fees, or nonfinancial support. Some authors declared owing stocks or being cofounders or employees in various companies.

Source: Lee K-W et al. Association of tumor mutational burden with efficacy of pembrolizumab ± chemotherapy as first-line therapy for gastric cancer in the phase III KEYNOTE-062 study. Clin Cancer Res. 2022 (Jun 3). Doi: 10.1158/1078-0432.CCR-22-0121

Key clinical point: High tumor mutational burden (TMB) is associated with clinical outcomes with pembrolizumab with or without chemotherapy in patients with gastric/gastroesophageal junction adenocarcinoma.

Major finding: In patients with high TMB, pembrolizumab vs. chemotherapy significantly improved the objective response rate (ORR; 55.6% vs. 41.2%), progression-free survival (PFS; hazard ratio [HR] 0.52), and overall survival (OS; HR 0.34). Similarly, pembrolizumab plus chemotherapy vs. chemotherapy improved ORR (73.3% vs. 41.2%), PFS (HR 0.62), and OS (HR 0.54) in patients with high TMB.

Study details: This prespecified exploratory analysis of phase 3 KEYNOTE-062 study included patients with gastric cancer who were randomly assigned (1:1:1) to receive pembrolizumab, pembrolizumab plus chemotherapy, or placebo plus chemotherapy.

Disclosures: This study was funded by Merck Sharp and Dohme LLC. The authors declared receiving grants, personal or advisory fees, or nonfinancial support. Some authors declared owing stocks or being cofounders or employees in various companies.

Source: Lee K-W et al. Association of tumor mutational burden with efficacy of pembrolizumab ± chemotherapy as first-line therapy for gastric cancer in the phase III KEYNOTE-062 study. Clin Cancer Res. 2022 (Jun 3). Doi: 10.1158/1078-0432.CCR-22-0121

Key clinical point: Ramucirumab in combination with irinotecan fails to improve the progression-free survival (PFS) rate at 6 months in patients with previously treated advanced gastric cancer.

Major finding: The 6-month PFS rate was 26.5% (P = .1353). The median PFS was 4.2 months, and the median overall survival was 9.6 months. The most common grade ≥3 adverse events were neutropenia (51%), leucopenia (43%), anemia (20%), anorexia (14%), and febrile neutropenia (11%). There were no treatment-related deaths or new safety signals.

Study details: This study was a single-arm, phase 2 multicenter trial of 35 patients (HGCSG 1603)  with previously treated advanced gastric cancer who received the second-line ramucirumab plus irinotecan. The primary endpoint was the 6-month PFS rate.

Disclosures: This study was supported by Eli Lilly Japan K.K.  Several of the authors received honoraria or research funding or declared ownership interests outside this work, including with Eli Lilly Japan.

Source: Kawamoto Y et al. Phase II study of ramucirumab plus irinotecan combination therapy as second-line treatment in patients with advanced gastric cancer: HGCSG1603. Oncologist. 2022 (May 17). Doi: 10.1093/oncolo/oyac086

Key clinical point: Ramucirumab in combination with irinotecan fails to improve the progression-free survival (PFS) rate at 6 months in patients with previously treated advanced gastric cancer.

Major finding: The 6-month PFS rate was 26.5% (P = .1353). The median PFS was 4.2 months, and the median overall survival was 9.6 months. The most common grade ≥3 adverse events were neutropenia (51%), leucopenia (43%), anemia (20%), anorexia (14%), and febrile neutropenia (11%). There were no treatment-related deaths or new safety signals.

Study details: This study was a single-arm, phase 2 multicenter trial of 35 patients (HGCSG 1603)  with previously treated advanced gastric cancer who received the second-line ramucirumab plus irinotecan. The primary endpoint was the 6-month PFS rate.

Disclosures: This study was supported by Eli Lilly Japan K.K.  Several of the authors received honoraria or research funding or declared ownership interests outside this work, including with Eli Lilly Japan.

Source: Kawamoto Y et al. Phase II study of ramucirumab plus irinotecan combination therapy as second-line treatment in patients with advanced gastric cancer: HGCSG1603. Oncologist. 2022 (May 17). Doi: 10.1093/oncolo/oyac086

Key clinical point: Ramucirumab in combination with irinotecan fails to improve the progression-free survival (PFS) rate at 6 months in patients with previously treated advanced gastric cancer.

Major finding: The 6-month PFS rate was 26.5% (P = .1353). The median PFS was 4.2 months, and the median overall survival was 9.6 months. The most common grade ≥3 adverse events were neutropenia (51%), leucopenia (43%), anemia (20%), anorexia (14%), and febrile neutropenia (11%). There were no treatment-related deaths or new safety signals.

Study details: This study was a single-arm, phase 2 multicenter trial of 35 patients (HGCSG 1603)  with previously treated advanced gastric cancer who received the second-line ramucirumab plus irinotecan. The primary endpoint was the 6-month PFS rate.

Disclosures: This study was supported by Eli Lilly Japan K.K.  Several of the authors received honoraria or research funding or declared ownership interests outside this work, including with Eli Lilly Japan.

Source: Kawamoto Y et al. Phase II study of ramucirumab plus irinotecan combination therapy as second-line treatment in patients with advanced gastric cancer: HGCSG1603. Oncologist. 2022 (May 17). Doi: 10.1093/oncolo/oyac086

NATIONAL HARBOR, MD. – The latest updates on COVID-19 vaccination response among patients with multiple sclerosis (MS) who are treated with disease-modifying therapy (DMT) show that, if patients do contract the virus, cases are mild and serious infections are rare.

However, vaccine antibody response remains lower with anti-CD20 therapies.

One of several late-breaking studies on these issues that were presented at the annual meeting of the Consortium of Multiple Sclerosis Centers included more than 100 patients with MS who were treated with a variety of DMTs.

Results showed that the rate of antibody response was just 55% among those treated with anti-CD20 therapies versus 83% for those treated with other DMTs, including sphingosine-1-phosphate receptor modulators (S1Ps).

Consistent with what has been observed in other studies, “vaccine antibody responses were slightly lower in B cell–depleted patients than with other therapies,” senior author Rahul Dave, MD, director of the INOVA MS and Neuroimmunology Center, Inova Neurosciences Institute, the University of Virginia, Fairfax, said in an interview.
 

Vaccine response

The investigators sought to assess detailed vaccine responses in 134 patients with MS. Serum COVID antibody measures were conducted approximately 3 weeks to 4 months after vaccination – and mostly after the initial vaccination.

The antibody response rate was significantly lower with anti-CD20 treatments (55%) than with all other DMTs examined (83%), including S1Ps, immunomodulators, immunosuppressive drugs, interferon B, anti-CD52, and natalizumab (P < .01).

The highest prevalence of antibody response was observed among those taking immunomodulators; responses occurred among 91% of patients taking teriflunomide and among 93% of those taking fumarates.

Among those treated with anti-CD20 therapy, antibody responses correlated with higher baseline immunoglobulin levels (P = .01) and shorter durations of therapy.

“We found that longer total duration of therapy and lower immunoglobulin levels tended to correlate with decreases in immune responses,” said Dr. Dave.

“Interestingly, the timing between vaccination versus administration of [anti-CD20 drug] ocrelizumab did not seem to be impactful with regards to antibody responses,” Dr. Dave noted. He added that this is contrary to some past studies that showed benefits if the vaccination could be completed prior to starting ocrelizumab.

Sixteen participants tested polymerase chain reaction positive for COVID during the previous 12 months. Although most infections were described as mild and self-limited, four of the patients received outpatient monoclonal antibody therapy, and one required hospitalization because of COVID.

“I think it is notable and reassuring that, overall, our patients had mild courses. This is consistent with the vaccines ‘working,’ and is true even in patients on high-efficacy immunosuppressants that partially abrogate antibody responses,” Dr. Dave said.

He added that he reassures patients who need high-efficacy therapies that “they should use them.”

That being said, as in the general population, even vaccinated patients can get COVID. “You can be sick and feel terrible, but in general, hospitalization numbers are way down compared to 2 years ago. We are seeing the same trends in MS patients, including the B cell–depleted patients,” he said.

“To get at the question whether B cell–depleted patients behave exactly the same as the general population, or even [with] other DMTs, we will need large, multicenter, prospective datasets,” said Dr. Dave.
 

Favorable findings

Two other late-breaking posters at the meeting provided updates regarding antibody responses among patients receiving S1Ps. There has been concern that S1Ps may blunt antibody responses to COVID vaccinations.

The concern is in regard to their unique mechanisms of sequestering circulating lymphocytes, particularly the older, nonselective S1P receptor modulator fingolimod, said the author of one of the studies, Daniel Kantor, MD, president emeritus of the Florida Society of Neurology and founding president of the Medical Partnership 4 MS+.

“It appears the issues with fingolimod might relate to the level of white blood cell sequestration, [which is] greater in fingolimod than the newer S1P receptor modulators, and/or the result of S1P4 receptor modulation, which is not seen with the newer, selective medications,” Dr. Kantor said in an interview.

In a prospective observational trial of patients with relapsing MS, among 30 participants who were treated with ozanimod, the mean increase in IgG antibody titer 4 weeks after either of the two available mRNA vaccines was 232.73 AU/mL versus a mean increase of 526.59 AU/mL among 30 non–ozanimod/DMT-treated patients.

To date, only three patients in the study were taking ocrelizumab; for those patients, the mean increase in IgG titers was 0.633.

Despite the lower antibody titers in the ozanimod-treated patients, which Dr. Kantor noted are generally regarded as protective, all but one of the patients had positive results on T-Detect, which was indicative of vaccine protection.

“In this study, [relapsing] MS patients treated with ozanimod had an antibody and T-cell response to the mRNA COVID-19 vaccines,” he reported. “This trial is ongoing, with 48 weeks of follow-up expected in December 2022.”
 

Ponesimod results

In the other S1P modulator-related late-breaking study, Janssen Research and Development reported on antibody responses of patients who were treated with the S1P drug ponesimod in the phase 2 AC-058B202 study.

The median exposure to ponesimod at time of vaccination was 10.7 years (range, 9.8-11.8 years). There were 134 patients in the study. Of those, both prevaccination and postvaccination blood samples from 49 patients were tested for spike antibody concentrations.

Among those participants, 40 (81.6%) met the definition of response to the COVID-19 vaccination, defined as seroconversion in the case of negative prevaccination antibody testing or a fourfold antibody concentration increase in the case of a positive prevaccination antibody result.

Of the 38 antibody-negative participants, 33 (86.8%) achieved seroconversion post vaccination.

A total of 20 participants reported having had prevaccine COVID, while 17 had postvaccination COVID.

None of the cases were serious, severe, or fatal, and none led to permanent treatment discontinuation.

“In patients with RMS on ponesimod, the majority (> 80%) appear to develop a measurable SARS-CoV-2 humoral response after COVID-19 vaccination,” the authors, led by Janice Wong, of Janssen Research and Development, wrote.

“Further investigations on the efficacy and safety of COVID-19 vaccination in MS patients on ponesimod are warranted,” they added.

In a final study from Genentech, of 4848 patients with MS who were fully vaccinated during the Delta and Omicron waves, 1.3% had a COVID-related hospitalization. In addition, rate of severe SARS-CoV-2 infections was very low (0.6%); there were fewer than 10 infections in each subgroup of DMTs. These patients included 585 (17%) who were treated with ocrelizumab, 238 (7%) who were treated with S1P receptor modulators, 33 (1%) who were treated with interferons, 1,004 (29%) who were treated with other DMTs, and 1,574 (46%) for whom no DMTs were recorded.

“We can conclude from this study that the characteristics of people with MS with more severe COVID-19 outcomes resemble those observed in the general population,” such as in those who are older or have higher rates of comorbidities, Preeti Bajaj, team lead of HEOR, Neuroscience, at Genentech, said in an interview. “We believe [ocrelizumab] treatment decisions should be made between a patient and their treating neurologist or other medical professional based on a benefit-risk assessment specific to the individual patient.”
 

Concerns remain

In a comment, Bruce A. C. Cree, MD, PhD, professor of clinical neurology and clinical research director at the Weill Institute for Neurosciences, University of California, San Francisco, described the overall data on vaccine efficacy on anti-CD20s as “discouraging” and said he is adjusting his own recommendations for these patients.

“Repeated vaccinations do not seem to stimulate humoral responses in B cell–depleted patients,” said Dr. Cree, who was not involved with the research.

“In my personal practice, I have been suspending dosing in my patients to allow for B-cell reconstitution to occur followed by revaccination,” he added.

Regarding the S1P drugs, he noted that, aside from fingolimod, “the antibody response frequency seems to be better than initial reports. However, the index values are low and may not be protective.”

Overall, the take-home message for patients with MS who are taking DMTs should be, “all patients treated with S1P modulators or anti-C20 antibodies should be vaccinated and boosted,” Dr. Cree said.

“In some cases, temporary interruption of treatment might be useful to help develop robust responses to vaccinations,” he added.

Dr. Dave reported no financial relationships regarding the poster but is a paid speaker/consultant for Novartis, Bristol-Myers Squibb, EMD Serono, Biogen, Alexion, Genentech, Horizon, and Sanofi for their MS & NMO therapies. Dr. Kantor’s research was supported by a grant from BMS; he is a consultant for Biogen, BMS, and Janssen. Dr. Cree reported that he is an unpaid consultant for BMS, the manufacturer of ozanimod.

A version of this article first appeared on Medscape.com.

NATIONAL HARBOR, MD. – The latest updates on COVID-19 vaccination response among patients with multiple sclerosis (MS) who are treated with disease-modifying therapy (DMT) show that, if patients do contract the virus, cases are mild and serious infections are rare.

However, vaccine antibody response remains lower with anti-CD20 therapies.

One of several late-breaking studies on these issues that were presented at the annual meeting of the Consortium of Multiple Sclerosis Centers included more than 100 patients with MS who were treated with a variety of DMTs.

Results showed that the rate of antibody response was just 55% among those treated with anti-CD20 therapies versus 83% for those treated with other DMTs, including sphingosine-1-phosphate receptor modulators (S1Ps).

Consistent with what has been observed in other studies, “vaccine antibody responses were slightly lower in B cell–depleted patients than with other therapies,” senior author Rahul Dave, MD, director of the INOVA MS and Neuroimmunology Center, Inova Neurosciences Institute, the University of Virginia, Fairfax, said in an interview.
 

Vaccine response

The investigators sought to assess detailed vaccine responses in 134 patients with MS. Serum COVID antibody measures were conducted approximately 3 weeks to 4 months after vaccination – and mostly after the initial vaccination.

The antibody response rate was significantly lower with anti-CD20 treatments (55%) than with all other DMTs examined (83%), including S1Ps, immunomodulators, immunosuppressive drugs, interferon B, anti-CD52, and natalizumab (P < .01).

The highest prevalence of antibody response was observed among those taking immunomodulators; responses occurred among 91% of patients taking teriflunomide and among 93% of those taking fumarates.

Among those treated with anti-CD20 therapy, antibody responses correlated with higher baseline immunoglobulin levels (P = .01) and shorter durations of therapy.

“We found that longer total duration of therapy and lower immunoglobulin levels tended to correlate with decreases in immune responses,” said Dr. Dave.

“Interestingly, the timing between vaccination versus administration of [anti-CD20 drug] ocrelizumab did not seem to be impactful with regards to antibody responses,” Dr. Dave noted. He added that this is contrary to some past studies that showed benefits if the vaccination could be completed prior to starting ocrelizumab.

Sixteen participants tested polymerase chain reaction positive for COVID during the previous 12 months. Although most infections were described as mild and self-limited, four of the patients received outpatient monoclonal antibody therapy, and one required hospitalization because of COVID.

“I think it is notable and reassuring that, overall, our patients had mild courses. This is consistent with the vaccines ‘working,’ and is true even in patients on high-efficacy immunosuppressants that partially abrogate antibody responses,” Dr. Dave said.

He added that he reassures patients who need high-efficacy therapies that “they should use them.”

That being said, as in the general population, even vaccinated patients can get COVID. “You can be sick and feel terrible, but in general, hospitalization numbers are way down compared to 2 years ago. We are seeing the same trends in MS patients, including the B cell–depleted patients,” he said.

“To get at the question whether B cell–depleted patients behave exactly the same as the general population, or even [with] other DMTs, we will need large, multicenter, prospective datasets,” said Dr. Dave.
 

Favorable findings

Two other late-breaking posters at the meeting provided updates regarding antibody responses among patients receiving S1Ps. There has been concern that S1Ps may blunt antibody responses to COVID vaccinations.

The concern is in regard to their unique mechanisms of sequestering circulating lymphocytes, particularly the older, nonselective S1P receptor modulator fingolimod, said the author of one of the studies, Daniel Kantor, MD, president emeritus of the Florida Society of Neurology and founding president of the Medical Partnership 4 MS+.

“It appears the issues with fingolimod might relate to the level of white blood cell sequestration, [which is] greater in fingolimod than the newer S1P receptor modulators, and/or the result of S1P4 receptor modulation, which is not seen with the newer, selective medications,” Dr. Kantor said in an interview.

In a prospective observational trial of patients with relapsing MS, among 30 participants who were treated with ozanimod, the mean increase in IgG antibody titer 4 weeks after either of the two available mRNA vaccines was 232.73 AU/mL versus a mean increase of 526.59 AU/mL among 30 non–ozanimod/DMT-treated patients.

To date, only three patients in the study were taking ocrelizumab; for those patients, the mean increase in IgG titers was 0.633.

Despite the lower antibody titers in the ozanimod-treated patients, which Dr. Kantor noted are generally regarded as protective, all but one of the patients had positive results on T-Detect, which was indicative of vaccine protection.

“In this study, [relapsing] MS patients treated with ozanimod had an antibody and T-cell response to the mRNA COVID-19 vaccines,” he reported. “This trial is ongoing, with 48 weeks of follow-up expected in December 2022.”
 

Ponesimod results

In the other S1P modulator-related late-breaking study, Janssen Research and Development reported on antibody responses of patients who were treated with the S1P drug ponesimod in the phase 2 AC-058B202 study.

The median exposure to ponesimod at time of vaccination was 10.7 years (range, 9.8-11.8 years). There were 134 patients in the study. Of those, both prevaccination and postvaccination blood samples from 49 patients were tested for spike antibody concentrations.

Among those participants, 40 (81.6%) met the definition of response to the COVID-19 vaccination, defined as seroconversion in the case of negative prevaccination antibody testing or a fourfold antibody concentration increase in the case of a positive prevaccination antibody result.

Of the 38 antibody-negative participants, 33 (86.8%) achieved seroconversion post vaccination.

A total of 20 participants reported having had prevaccine COVID, while 17 had postvaccination COVID.

None of the cases were serious, severe, or fatal, and none led to permanent treatment discontinuation.

“In patients with RMS on ponesimod, the majority (> 80%) appear to develop a measurable SARS-CoV-2 humoral response after COVID-19 vaccination,” the authors, led by Janice Wong, of Janssen Research and Development, wrote.

“Further investigations on the efficacy and safety of COVID-19 vaccination in MS patients on ponesimod are warranted,” they added.

In a final study from Genentech, of 4848 patients with MS who were fully vaccinated during the Delta and Omicron waves, 1.3% had a COVID-related hospitalization. In addition, rate of severe SARS-CoV-2 infections was very low (0.6%); there were fewer than 10 infections in each subgroup of DMTs. These patients included 585 (17%) who were treated with ocrelizumab, 238 (7%) who were treated with S1P receptor modulators, 33 (1%) who were treated with interferons, 1,004 (29%) who were treated with other DMTs, and 1,574 (46%) for whom no DMTs were recorded.

“We can conclude from this study that the characteristics of people with MS with more severe COVID-19 outcomes resemble those observed in the general population,” such as in those who are older or have higher rates of comorbidities, Preeti Bajaj, team lead of HEOR, Neuroscience, at Genentech, said in an interview. “We believe [ocrelizumab] treatment decisions should be made between a patient and their treating neurologist or other medical professional based on a benefit-risk assessment specific to the individual patient.”
 

Concerns remain

In a comment, Bruce A. C. Cree, MD, PhD, professor of clinical neurology and clinical research director at the Weill Institute for Neurosciences, University of California, San Francisco, described the overall data on vaccine efficacy on anti-CD20s as “discouraging” and said he is adjusting his own recommendations for these patients.

“Repeated vaccinations do not seem to stimulate humoral responses in B cell–depleted patients,” said Dr. Cree, who was not involved with the research.

“In my personal practice, I have been suspending dosing in my patients to allow for B-cell reconstitution to occur followed by revaccination,” he added.

Regarding the S1P drugs, he noted that, aside from fingolimod, “the antibody response frequency seems to be better than initial reports. However, the index values are low and may not be protective.”

Overall, the take-home message for patients with MS who are taking DMTs should be, “all patients treated with S1P modulators or anti-C20 antibodies should be vaccinated and boosted,” Dr. Cree said.

“In some cases, temporary interruption of treatment might be useful to help develop robust responses to vaccinations,” he added.

Dr. Dave reported no financial relationships regarding the poster but is a paid speaker/consultant for Novartis, Bristol-Myers Squibb, EMD Serono, Biogen, Alexion, Genentech, Horizon, and Sanofi for their MS & NMO therapies. Dr. Kantor’s research was supported by a grant from BMS; he is a consultant for Biogen, BMS, and Janssen. Dr. Cree reported that he is an unpaid consultant for BMS, the manufacturer of ozanimod.

A version of this article first appeared on Medscape.com.

NATIONAL HARBOR, MD. – The latest updates on COVID-19 vaccination response among patients with multiple sclerosis (MS) who are treated with disease-modifying therapy (DMT) show that, if patients do contract the virus, cases are mild and serious infections are rare.

However, vaccine antibody response remains lower with anti-CD20 therapies.

One of several late-breaking studies on these issues that were presented at the annual meeting of the Consortium of Multiple Sclerosis Centers included more than 100 patients with MS who were treated with a variety of DMTs.

Results showed that the rate of antibody response was just 55% among those treated with anti-CD20 therapies versus 83% for those treated with other DMTs, including sphingosine-1-phosphate receptor modulators (S1Ps).

Consistent with what has been observed in other studies, “vaccine antibody responses were slightly lower in B cell–depleted patients than with other therapies,” senior author Rahul Dave, MD, director of the INOVA MS and Neuroimmunology Center, Inova Neurosciences Institute, the University of Virginia, Fairfax, said in an interview.
 

Vaccine response

The investigators sought to assess detailed vaccine responses in 134 patients with MS. Serum COVID antibody measures were conducted approximately 3 weeks to 4 months after vaccination – and mostly after the initial vaccination.

The antibody response rate was significantly lower with anti-CD20 treatments (55%) than with all other DMTs examined (83%), including S1Ps, immunomodulators, immunosuppressive drugs, interferon B, anti-CD52, and natalizumab (P < .01).

The highest prevalence of antibody response was observed among those taking immunomodulators; responses occurred among 91% of patients taking teriflunomide and among 93% of those taking fumarates.

Among those treated with anti-CD20 therapy, antibody responses correlated with higher baseline immunoglobulin levels (P = .01) and shorter durations of therapy.

“We found that longer total duration of therapy and lower immunoglobulin levels tended to correlate with decreases in immune responses,” said Dr. Dave.

“Interestingly, the timing between vaccination versus administration of [anti-CD20 drug] ocrelizumab did not seem to be impactful with regards to antibody responses,” Dr. Dave noted. He added that this is contrary to some past studies that showed benefits if the vaccination could be completed prior to starting ocrelizumab.

Sixteen participants tested polymerase chain reaction positive for COVID during the previous 12 months. Although most infections were described as mild and self-limited, four of the patients received outpatient monoclonal antibody therapy, and one required hospitalization because of COVID.

“I think it is notable and reassuring that, overall, our patients had mild courses. This is consistent with the vaccines ‘working,’ and is true even in patients on high-efficacy immunosuppressants that partially abrogate antibody responses,” Dr. Dave said.

He added that he reassures patients who need high-efficacy therapies that “they should use them.”

That being said, as in the general population, even vaccinated patients can get COVID. “You can be sick and feel terrible, but in general, hospitalization numbers are way down compared to 2 years ago. We are seeing the same trends in MS patients, including the B cell–depleted patients,” he said.

“To get at the question whether B cell–depleted patients behave exactly the same as the general population, or even [with] other DMTs, we will need large, multicenter, prospective datasets,” said Dr. Dave.
 

Favorable findings

Two other late-breaking posters at the meeting provided updates regarding antibody responses among patients receiving S1Ps. There has been concern that S1Ps may blunt antibody responses to COVID vaccinations.

The concern is in regard to their unique mechanisms of sequestering circulating lymphocytes, particularly the older, nonselective S1P receptor modulator fingolimod, said the author of one of the studies, Daniel Kantor, MD, president emeritus of the Florida Society of Neurology and founding president of the Medical Partnership 4 MS+.

“It appears the issues with fingolimod might relate to the level of white blood cell sequestration, [which is] greater in fingolimod than the newer S1P receptor modulators, and/or the result of S1P4 receptor modulation, which is not seen with the newer, selective medications,” Dr. Kantor said in an interview.

In a prospective observational trial of patients with relapsing MS, among 30 participants who were treated with ozanimod, the mean increase in IgG antibody titer 4 weeks after either of the two available mRNA vaccines was 232.73 AU/mL versus a mean increase of 526.59 AU/mL among 30 non–ozanimod/DMT-treated patients.

To date, only three patients in the study were taking ocrelizumab; for those patients, the mean increase in IgG titers was 0.633.

Despite the lower antibody titers in the ozanimod-treated patients, which Dr. Kantor noted are generally regarded as protective, all but one of the patients had positive results on T-Detect, which was indicative of vaccine protection.

“In this study, [relapsing] MS patients treated with ozanimod had an antibody and T-cell response to the mRNA COVID-19 vaccines,” he reported. “This trial is ongoing, with 48 weeks of follow-up expected in December 2022.”
 

Ponesimod results

In the other S1P modulator-related late-breaking study, Janssen Research and Development reported on antibody responses of patients who were treated with the S1P drug ponesimod in the phase 2 AC-058B202 study.

The median exposure to ponesimod at time of vaccination was 10.7 years (range, 9.8-11.8 years). There were 134 patients in the study. Of those, both prevaccination and postvaccination blood samples from 49 patients were tested for spike antibody concentrations.

Among those participants, 40 (81.6%) met the definition of response to the COVID-19 vaccination, defined as seroconversion in the case of negative prevaccination antibody testing or a fourfold antibody concentration increase in the case of a positive prevaccination antibody result.

Of the 38 antibody-negative participants, 33 (86.8%) achieved seroconversion post vaccination.

A total of 20 participants reported having had prevaccine COVID, while 17 had postvaccination COVID.

None of the cases were serious, severe, or fatal, and none led to permanent treatment discontinuation.

“In patients with RMS on ponesimod, the majority (> 80%) appear to develop a measurable SARS-CoV-2 humoral response after COVID-19 vaccination,” the authors, led by Janice Wong, of Janssen Research and Development, wrote.

“Further investigations on the efficacy and safety of COVID-19 vaccination in MS patients on ponesimod are warranted,” they added.

In a final study from Genentech, of 4848 patients with MS who were fully vaccinated during the Delta and Omicron waves, 1.3% had a COVID-related hospitalization. In addition, rate of severe SARS-CoV-2 infections was very low (0.6%); there were fewer than 10 infections in each subgroup of DMTs. These patients included 585 (17%) who were treated with ocrelizumab, 238 (7%) who were treated with S1P receptor modulators, 33 (1%) who were treated with interferons, 1,004 (29%) who were treated with other DMTs, and 1,574 (46%) for whom no DMTs were recorded.

“We can conclude from this study that the characteristics of people with MS with more severe COVID-19 outcomes resemble those observed in the general population,” such as in those who are older or have higher rates of comorbidities, Preeti Bajaj, team lead of HEOR, Neuroscience, at Genentech, said in an interview. “We believe [ocrelizumab] treatment decisions should be made between a patient and their treating neurologist or other medical professional based on a benefit-risk assessment specific to the individual patient.”
 

Concerns remain

In a comment, Bruce A. C. Cree, MD, PhD, professor of clinical neurology and clinical research director at the Weill Institute for Neurosciences, University of California, San Francisco, described the overall data on vaccine efficacy on anti-CD20s as “discouraging” and said he is adjusting his own recommendations for these patients.

“Repeated vaccinations do not seem to stimulate humoral responses in B cell–depleted patients,” said Dr. Cree, who was not involved with the research.

“In my personal practice, I have been suspending dosing in my patients to allow for B-cell reconstitution to occur followed by revaccination,” he added.

Regarding the S1P drugs, he noted that, aside from fingolimod, “the antibody response frequency seems to be better than initial reports. However, the index values are low and may not be protective.”

Overall, the take-home message for patients with MS who are taking DMTs should be, “all patients treated with S1P modulators or anti-C20 antibodies should be vaccinated and boosted,” Dr. Cree said.

“In some cases, temporary interruption of treatment might be useful to help develop robust responses to vaccinations,” he added.

Dr. Dave reported no financial relationships regarding the poster but is a paid speaker/consultant for Novartis, Bristol-Myers Squibb, EMD Serono, Biogen, Alexion, Genentech, Horizon, and Sanofi for their MS & NMO therapies. Dr. Kantor’s research was supported by a grant from BMS; he is a consultant for Biogen, BMS, and Janssen. Dr. Cree reported that he is an unpaid consultant for BMS, the manufacturer of ozanimod.

A version of this article first appeared on Medscape.com.

A rapid, saliva-based test for COVID-19 could enable testing, diagnosis, and prescribing to take place in a single office visit by immediately confirming whether a patient has the infection and needs to be treated, researchers say. The test has sparked commercial interest and earned additional funding from the Canadian government.

The test uses a DNA aptamer – a short, synthetic oligonucleotide that binds to a specific molecular target – that shows high affinity for the SARS-CoV-2 spike protein and its variants. The approach “can be rapidly adapted to different threats,” as well, Leyla Soleymani, PhD, an associate professor of engineering physics at McMaster University, Hamilton, Ontario, Canada, told this news organization. Her team invented the approach.
 

Adaptable to other pathogens

Current gold-standard COVID-19 tests are based on reverse transcription-polymerase chain reaction (RT-PCR), which are sensitive but costly, complicated, and require waiting at least a couple of days for results, according to Dr. Soleymani and colleagues. Rapid nucleic acid and antigen tests have only “moderate” sensitivity and specificity, particularly when viral loads are low. None have been shown to work well with saliva samples.

By contrast, the new test “uses a reader and test cartridges, similar to the glucose reader,” said Dr. Soleymani, who is also Canada Research chair in Miniaturized Biomedical Devices. A small sample of saliva is added to a chemical reagent and inserted into the reader, which is attached to a smartphone. Once commercialized, the point-of-care test is expected to be performed quickly in a physician’s office or in a clinic.

“The same reader can be applied to a variety of infectious diseases or infection panels by developing new cartridges,” Dr. Soleymani explained. “Noroviruses and bacteria such as C. difficile are on our list” to examine next.What’s more, she added, “this test is ideally positioned for settings where access to centralized labs is not possible, such as less developed countries.”

The team’s recent studies seem to support the promise. A study published last year in the international edition of Angewandte Chemie documents the development of the test, which at that point could detect wild-type SARS-CoV-2 and its Alpha and Delta variants in unprocessed saliva samples in 10 minutes with 80.5% sensitivity and 100% specificity.

This study was followed in January 2022 by a paper in Chemistry showing that the device also detected Alpha, Gamma, Epsilon, Kappa, and Omicron variants, demonstrating its potential for recognizing rapidly evolving targets such as those found in SARS-CoV-2.

In another demonstration of its versatility, the technology was recently adapted and successfully detected animal viruses from saliva samples.
 

Commercial and government funding

The findings prompted Zentek, an intellectual property development and commercialization company in Guelph, Ont., to license the technology, with plans to invest more than $1 million in the next 5 years to scale up production of the test components and adapt the technology for other forms of infection.

Furthermore, the collaborative efforts required to develop the test and move it forward gained funding from Canada’s Natural Sciences and Engineering Research Council, which is investing nearly $1.5 million in the form of two grants: $1 million to further streamline the technology development in preparation for the next pandemic and $488,440 (including $140,000 from Zentek) to get the current test to market as quickly as possible.

Meanwhile, Dr. Soleymani is urging clinicians “to be open to nontraditional diagnostic approaches even if the traditional tests do the job. Such tests are more rapid and can be used to enable personalized medicine. Our success relies on collaboration and support from clinicians.”
 

Further validation needed

Daniel Kuritzkes, MD, chief of infectious diseases at Brigham and Women’s Hospital and the Harriet Ryan Albee Professor of Medicine at Harvard Medical School, Boston, commented on the study in response to a request from this news organization.

While “it’s always good to have more testing options available,” he said, “we don’t yet have very much information about performance characteristics of the test – that is, its sensitivity and specificity. I’d like to see the performance characteristics of this test compared to PCR tests and to the current rapid antigen tests using a large number of patient samples with currently circulating variants, and tests over time to see how soon tests become positive after symptom onset and for how long they remain positive.”

“Further validation studies and emergency use authorization or approval by regulatory authorities are needed before we will see this test implemented in the field,” Dr. Kuritzkes concluded.

A version of this article first appeared on Medscape.com.

A rapid, saliva-based test for COVID-19 could enable testing, diagnosis, and prescribing to take place in a single office visit by immediately confirming whether a patient has the infection and needs to be treated, researchers say. The test has sparked commercial interest and earned additional funding from the Canadian government.

The test uses a DNA aptamer – a short, synthetic oligonucleotide that binds to a specific molecular target – that shows high affinity for the SARS-CoV-2 spike protein and its variants. The approach “can be rapidly adapted to different threats,” as well, Leyla Soleymani, PhD, an associate professor of engineering physics at McMaster University, Hamilton, Ontario, Canada, told this news organization. Her team invented the approach.
 

Adaptable to other pathogens

Current gold-standard COVID-19 tests are based on reverse transcription-polymerase chain reaction (RT-PCR), which are sensitive but costly, complicated, and require waiting at least a couple of days for results, according to Dr. Soleymani and colleagues. Rapid nucleic acid and antigen tests have only “moderate” sensitivity and specificity, particularly when viral loads are low. None have been shown to work well with saliva samples.

By contrast, the new test “uses a reader and test cartridges, similar to the glucose reader,” said Dr. Soleymani, who is also Canada Research chair in Miniaturized Biomedical Devices. A small sample of saliva is added to a chemical reagent and inserted into the reader, which is attached to a smartphone. Once commercialized, the point-of-care test is expected to be performed quickly in a physician’s office or in a clinic.

“The same reader can be applied to a variety of infectious diseases or infection panels by developing new cartridges,” Dr. Soleymani explained. “Noroviruses and bacteria such as C. difficile are on our list” to examine next.What’s more, she added, “this test is ideally positioned for settings where access to centralized labs is not possible, such as less developed countries.”

The team’s recent studies seem to support the promise. A study published last year in the international edition of Angewandte Chemie documents the development of the test, which at that point could detect wild-type SARS-CoV-2 and its Alpha and Delta variants in unprocessed saliva samples in 10 minutes with 80.5% sensitivity and 100% specificity.

This study was followed in January 2022 by a paper in Chemistry showing that the device also detected Alpha, Gamma, Epsilon, Kappa, and Omicron variants, demonstrating its potential for recognizing rapidly evolving targets such as those found in SARS-CoV-2.

In another demonstration of its versatility, the technology was recently adapted and successfully detected animal viruses from saliva samples.
 

Commercial and government funding

The findings prompted Zentek, an intellectual property development and commercialization company in Guelph, Ont., to license the technology, with plans to invest more than $1 million in the next 5 years to scale up production of the test components and adapt the technology for other forms of infection.

Furthermore, the collaborative efforts required to develop the test and move it forward gained funding from Canada’s Natural Sciences and Engineering Research Council, which is investing nearly $1.5 million in the form of two grants: $1 million to further streamline the technology development in preparation for the next pandemic and $488,440 (including $140,000 from Zentek) to get the current test to market as quickly as possible.

Meanwhile, Dr. Soleymani is urging clinicians “to be open to nontraditional diagnostic approaches even if the traditional tests do the job. Such tests are more rapid and can be used to enable personalized medicine. Our success relies on collaboration and support from clinicians.”
 

Further validation needed

Daniel Kuritzkes, MD, chief of infectious diseases at Brigham and Women’s Hospital and the Harriet Ryan Albee Professor of Medicine at Harvard Medical School, Boston, commented on the study in response to a request from this news organization.

While “it’s always good to have more testing options available,” he said, “we don’t yet have very much information about performance characteristics of the test – that is, its sensitivity and specificity. I’d like to see the performance characteristics of this test compared to PCR tests and to the current rapid antigen tests using a large number of patient samples with currently circulating variants, and tests over time to see how soon tests become positive after symptom onset and for how long they remain positive.”

“Further validation studies and emergency use authorization or approval by regulatory authorities are needed before we will see this test implemented in the field,” Dr. Kuritzkes concluded.

A version of this article first appeared on Medscape.com.

A rapid, saliva-based test for COVID-19 could enable testing, diagnosis, and prescribing to take place in a single office visit by immediately confirming whether a patient has the infection and needs to be treated, researchers say. The test has sparked commercial interest and earned additional funding from the Canadian government.

The test uses a DNA aptamer – a short, synthetic oligonucleotide that binds to a specific molecular target – that shows high affinity for the SARS-CoV-2 spike protein and its variants. The approach “can be rapidly adapted to different threats,” as well, Leyla Soleymani, PhD, an associate professor of engineering physics at McMaster University, Hamilton, Ontario, Canada, told this news organization. Her team invented the approach.
 

Adaptable to other pathogens

Current gold-standard COVID-19 tests are based on reverse transcription-polymerase chain reaction (RT-PCR), which are sensitive but costly, complicated, and require waiting at least a couple of days for results, according to Dr. Soleymani and colleagues. Rapid nucleic acid and antigen tests have only “moderate” sensitivity and specificity, particularly when viral loads are low. None have been shown to work well with saliva samples.

By contrast, the new test “uses a reader and test cartridges, similar to the glucose reader,” said Dr. Soleymani, who is also Canada Research chair in Miniaturized Biomedical Devices. A small sample of saliva is added to a chemical reagent and inserted into the reader, which is attached to a smartphone. Once commercialized, the point-of-care test is expected to be performed quickly in a physician’s office or in a clinic.

“The same reader can be applied to a variety of infectious diseases or infection panels by developing new cartridges,” Dr. Soleymani explained. “Noroviruses and bacteria such as C. difficile are on our list” to examine next.What’s more, she added, “this test is ideally positioned for settings where access to centralized labs is not possible, such as less developed countries.”

The team’s recent studies seem to support the promise. A study published last year in the international edition of Angewandte Chemie documents the development of the test, which at that point could detect wild-type SARS-CoV-2 and its Alpha and Delta variants in unprocessed saliva samples in 10 minutes with 80.5% sensitivity and 100% specificity.

This study was followed in January 2022 by a paper in Chemistry showing that the device also detected Alpha, Gamma, Epsilon, Kappa, and Omicron variants, demonstrating its potential for recognizing rapidly evolving targets such as those found in SARS-CoV-2.

In another demonstration of its versatility, the technology was recently adapted and successfully detected animal viruses from saliva samples.
 

Commercial and government funding

The findings prompted Zentek, an intellectual property development and commercialization company in Guelph, Ont., to license the technology, with plans to invest more than $1 million in the next 5 years to scale up production of the test components and adapt the technology for other forms of infection.

Furthermore, the collaborative efforts required to develop the test and move it forward gained funding from Canada’s Natural Sciences and Engineering Research Council, which is investing nearly $1.5 million in the form of two grants: $1 million to further streamline the technology development in preparation for the next pandemic and $488,440 (including $140,000 from Zentek) to get the current test to market as quickly as possible.

Meanwhile, Dr. Soleymani is urging clinicians “to be open to nontraditional diagnostic approaches even if the traditional tests do the job. Such tests are more rapid and can be used to enable personalized medicine. Our success relies on collaboration and support from clinicians.”
 

Further validation needed

Daniel Kuritzkes, MD, chief of infectious diseases at Brigham and Women’s Hospital and the Harriet Ryan Albee Professor of Medicine at Harvard Medical School, Boston, commented on the study in response to a request from this news organization.

While “it’s always good to have more testing options available,” he said, “we don’t yet have very much information about performance characteristics of the test – that is, its sensitivity and specificity. I’d like to see the performance characteristics of this test compared to PCR tests and to the current rapid antigen tests using a large number of patient samples with currently circulating variants, and tests over time to see how soon tests become positive after symptom onset and for how long they remain positive.”

“Further validation studies and emergency use authorization or approval by regulatory authorities are needed before we will see this test implemented in the field,” Dr. Kuritzkes concluded.

A version of this article first appeared on Medscape.com.

Key clinical point: Multi-agent adjuvant chemotherapy (MAC) offers a survival benefit over single-agent adjuvant chemotherapy (SAC) in patients with stage III colon cancer (CC) aged 70-75 years, but not for older patients.

Major finding: MAC vs. SAC was associated with a survival benefit in patients aged 70-75 years (hazard ratio [HR] 0.81; P < .001), but not in those aged 76-80 (HR 0.90; P = .051), 81-85 (HR 0.97; P = .637), or 86-90+ (HR 0.95; P = .691) years.

Study details: This retrospective, age group-based study included 20,257 patients aged ≥70 years with stage III CC who received either SAC (n = 7334) or MAC (n = 12,923).

Disclosures: The study was supported by the Winship Research Informatics Shared Resource of Winship Cancer Institute of Emory University and US National Institutes of Health/National Cancer Institute. The authors declared no conflicts of interest.

Source: Khalil L et al. Survival outcomes of adjuvant chemotherapy in elderly patients with stage III colon cancer. Oncologist. 2022 (Jun 1). Doi: 10.1093/oncolo/oyac082

Key clinical point: Multi-agent adjuvant chemotherapy (MAC) offers a survival benefit over single-agent adjuvant chemotherapy (SAC) in patients with stage III colon cancer (CC) aged 70-75 years, but not for older patients.

Major finding: MAC vs. SAC was associated with a survival benefit in patients aged 70-75 years (hazard ratio [HR] 0.81; P < .001), but not in those aged 76-80 (HR 0.90; P = .051), 81-85 (HR 0.97; P = .637), or 86-90+ (HR 0.95; P = .691) years.

Study details: This retrospective, age group-based study included 20,257 patients aged ≥70 years with stage III CC who received either SAC (n = 7334) or MAC (n = 12,923).

Disclosures: The study was supported by the Winship Research Informatics Shared Resource of Winship Cancer Institute of Emory University and US National Institutes of Health/National Cancer Institute. The authors declared no conflicts of interest.

Source: Khalil L et al. Survival outcomes of adjuvant chemotherapy in elderly patients with stage III colon cancer. Oncologist. 2022 (Jun 1). Doi: 10.1093/oncolo/oyac082

Key clinical point: Multi-agent adjuvant chemotherapy (MAC) offers a survival benefit over single-agent adjuvant chemotherapy (SAC) in patients with stage III colon cancer (CC) aged 70-75 years, but not for older patients.

Major finding: MAC vs. SAC was associated with a survival benefit in patients aged 70-75 years (hazard ratio [HR] 0.81; P < .001), but not in those aged 76-80 (HR 0.90; P = .051), 81-85 (HR 0.97; P = .637), or 86-90+ (HR 0.95; P = .691) years.

Study details: This retrospective, age group-based study included 20,257 patients aged ≥70 years with stage III CC who received either SAC (n = 7334) or MAC (n = 12,923).

Disclosures: The study was supported by the Winship Research Informatics Shared Resource of Winship Cancer Institute of Emory University and US National Institutes of Health/National Cancer Institute. The authors declared no conflicts of interest.

Source: Khalil L et al. Survival outcomes of adjuvant chemotherapy in elderly patients with stage III colon cancer. Oncologist. 2022 (Jun 1). Doi: 10.1093/oncolo/oyac082

Key clinical point: Metabolic syndrome (MetS) and obesity in individuals aged between 20 and 49 years are associated with an increased risk for earlier-onset colorectal cancer (CRC).

Major finding: MetS (adjusted hazard ratio [aHR] 1.20; 95% CI 1.14-1.27) and a higher body mass index (BMI; 25.0-29.9 kg/m²: aHR 1.19; 95% CI 1.12-1.25; ≥30 kg/m²: aHR 1.45; 95% CI 1.31-1.61) and waist circumference (WC; ≥100 cm in men or ≥95 cm in women: aHR 1.53; 95% CI 1.34-1.74) were associated with an increased earlier-onset CRC risk.

Study details: Findings are from a nationwide population-based cohort study that enrolled 5,672,153 individuals aged 20-49 years with health checkup data (i.e., anthropometric measurement, laboratory test, and health behavior data), of which 8320 developed earlier-onset CRC.

Disclosures: The study received no funding. The authors declared no conflicts of interest.

Source: Jin EH et al. Association between metabolic syndrome and the risk of colorectal cancer diagnosed before 50 years according to tumor location. Gastroenterology. 2022 (May 26). Doi: 10.1053/j.gastro.2022.05.032

Key clinical point: Metabolic syndrome (MetS) and obesity in individuals aged between 20 and 49 years are associated with an increased risk for earlier-onset colorectal cancer (CRC).

Major finding: MetS (adjusted hazard ratio [aHR] 1.20; 95% CI 1.14-1.27) and a higher body mass index (BMI; 25.0-29.9 kg/m²: aHR 1.19; 95% CI 1.12-1.25; ≥30 kg/m²: aHR 1.45; 95% CI 1.31-1.61) and waist circumference (WC; ≥100 cm in men or ≥95 cm in women: aHR 1.53; 95% CI 1.34-1.74) were associated with an increased earlier-onset CRC risk.

Study details: Findings are from a nationwide population-based cohort study that enrolled 5,672,153 individuals aged 20-49 years with health checkup data (i.e., anthropometric measurement, laboratory test, and health behavior data), of which 8320 developed earlier-onset CRC.

Disclosures: The study received no funding. The authors declared no conflicts of interest.

Source: Jin EH et al. Association between metabolic syndrome and the risk of colorectal cancer diagnosed before 50 years according to tumor location. Gastroenterology. 2022 (May 26). Doi: 10.1053/j.gastro.2022.05.032

Key clinical point: Metabolic syndrome (MetS) and obesity in individuals aged between 20 and 49 years are associated with an increased risk for earlier-onset colorectal cancer (CRC).

Major finding: MetS (adjusted hazard ratio [aHR] 1.20; 95% CI 1.14-1.27) and a higher body mass index (BMI; 25.0-29.9 kg/m²: aHR 1.19; 95% CI 1.12-1.25; ≥30 kg/m²: aHR 1.45; 95% CI 1.31-1.61) and waist circumference (WC; ≥100 cm in men or ≥95 cm in women: aHR 1.53; 95% CI 1.34-1.74) were associated with an increased earlier-onset CRC risk.

Study details: Findings are from a nationwide population-based cohort study that enrolled 5,672,153 individuals aged 20-49 years with health checkup data (i.e., anthropometric measurement, laboratory test, and health behavior data), of which 8320 developed earlier-onset CRC.

Disclosures: The study received no funding. The authors declared no conflicts of interest.

Source: Jin EH et al. Association between metabolic syndrome and the risk of colorectal cancer diagnosed before 50 years according to tumor location. Gastroenterology. 2022 (May 26). Doi: 10.1053/j.gastro.2022.05.032

Key clinical point: Individuals with the highest vs. lowest intake of nuts and legumes had a 16% and 10% lower risk for colorectal cancer (CRC), respectively.

Major finding: The pooled relative risk (RR) for CRC among individuals with the highest vs. lowest consumption of nuts and legumes was 0.84 (95% CI 0.71-0.99) and 0.90 (95% CI 0.83-0.98), respectively. A once-daily consumption of 28 g nuts and 100 g legumes was associated with a 33% (RR 0.67; 95% CI 0.45-0.98) and 21% (RR 0.79; 95% CI 0.64-0.97) lower risk for CRC, respectively.

Study details: Findings are from a meta-analysis of 13 and 29 studies that evaluated the association of the consumption of nuts and legumes with CRC risk, respectively.

Disclosures: The study was supported by the National Research Foundation of Korea, Ministry of Science, ICT, and Future Planning. The authors declared no conflicts of interest.

Source: Jin S,  Je Y. Nuts and legumes consumption and risk of colorectal cancer: A systematic review and meta-analysis. Eur J Epidemiol. 2022 (May 27). Doi: 10.1007/s10654-022-00881-6

Key clinical point: Individuals with the highest vs. lowest intake of nuts and legumes had a 16% and 10% lower risk for colorectal cancer (CRC), respectively.

Major finding: The pooled relative risk (RR) for CRC among individuals with the highest vs. lowest consumption of nuts and legumes was 0.84 (95% CI 0.71-0.99) and 0.90 (95% CI 0.83-0.98), respectively. A once-daily consumption of 28 g nuts and 100 g legumes was associated with a 33% (RR 0.67; 95% CI 0.45-0.98) and 21% (RR 0.79; 95% CI 0.64-0.97) lower risk for CRC, respectively.

Study details: Findings are from a meta-analysis of 13 and 29 studies that evaluated the association of the consumption of nuts and legumes with CRC risk, respectively.

Disclosures: The study was supported by the National Research Foundation of Korea, Ministry of Science, ICT, and Future Planning. The authors declared no conflicts of interest.

Source: Jin S,  Je Y. Nuts and legumes consumption and risk of colorectal cancer: A systematic review and meta-analysis. Eur J Epidemiol. 2022 (May 27). Doi: 10.1007/s10654-022-00881-6

Key clinical point: Individuals with the highest vs. lowest intake of nuts and legumes had a 16% and 10% lower risk for colorectal cancer (CRC), respectively.

Major finding: The pooled relative risk (RR) for CRC among individuals with the highest vs. lowest consumption of nuts and legumes was 0.84 (95% CI 0.71-0.99) and 0.90 (95% CI 0.83-0.98), respectively. A once-daily consumption of 28 g nuts and 100 g legumes was associated with a 33% (RR 0.67; 95% CI 0.45-0.98) and 21% (RR 0.79; 95% CI 0.64-0.97) lower risk for CRC, respectively.

Study details: Findings are from a meta-analysis of 13 and 29 studies that evaluated the association of the consumption of nuts and legumes with CRC risk, respectively.

Disclosures: The study was supported by the National Research Foundation of Korea, Ministry of Science, ICT, and Future Planning. The authors declared no conflicts of interest.

Source: Jin S,  Je Y. Nuts and legumes consumption and risk of colorectal cancer: A systematic review and meta-analysis. Eur J Epidemiol. 2022 (May 27). Doi: 10.1007/s10654-022-00881-6

Key clinical point: Compared with hybrid and open resection, simultaneous laparoscopic resection of colorectal cancer (CRC) and liver metastases offers improved postoperative outcomes and equivalent long-term oncological outcomes.

Major finding: The laparoscopic group had a lower wound complication rate than the open group (2.1% vs. 13.2%; P = .028) and a shorter postoperative hospital stay than the hybrid and open groups (8 vs. 11 days; P < .001 for both). The 5-year liver-specific recurrence rates were similar between the laparoscopic and hybrid groups (P = .270) and between the laparoscopic and open groups (P = .391).

Study details: The data come from a retrospective study including 647 patients who underwent simultaneous surgery for primary CRC and synchronous liver metastases and were categorized into the laparoscopic (n = 42) vs. hybrid (n = 81) and laparoscopic (n = 48) vs. open (n = 136) group sets after propensity score matching.

Disclosures: The study received no financial support. The authors declared no conflicts of interest.

Source: Lim H-K et al. Outcomes of simultaneous laparoscopic, hybrid, and open resection in colorectal cancer with synchronous liver metastases: a propensity score-matched study. Sci Rep. 2022;12:8867 (May 25). Doi: 10.1038/s41598-022-12372-5

Key clinical point: Compared with hybrid and open resection, simultaneous laparoscopic resection of colorectal cancer (CRC) and liver metastases offers improved postoperative outcomes and equivalent long-term oncological outcomes.

Major finding: The laparoscopic group had a lower wound complication rate than the open group (2.1% vs. 13.2%; P = .028) and a shorter postoperative hospital stay than the hybrid and open groups (8 vs. 11 days; P < .001 for both). The 5-year liver-specific recurrence rates were similar between the laparoscopic and hybrid groups (P = .270) and between the laparoscopic and open groups (P = .391).

Study details: The data come from a retrospective study including 647 patients who underwent simultaneous surgery for primary CRC and synchronous liver metastases and were categorized into the laparoscopic (n = 42) vs. hybrid (n = 81) and laparoscopic (n = 48) vs. open (n = 136) group sets after propensity score matching.

Disclosures: The study received no financial support. The authors declared no conflicts of interest.

Source: Lim H-K et al. Outcomes of simultaneous laparoscopic, hybrid, and open resection in colorectal cancer with synchronous liver metastases: a propensity score-matched study. Sci Rep. 2022;12:8867 (May 25). Doi: 10.1038/s41598-022-12372-5

Key clinical point: Compared with hybrid and open resection, simultaneous laparoscopic resection of colorectal cancer (CRC) and liver metastases offers improved postoperative outcomes and equivalent long-term oncological outcomes.

Major finding: The laparoscopic group had a lower wound complication rate than the open group (2.1% vs. 13.2%; P = .028) and a shorter postoperative hospital stay than the hybrid and open groups (8 vs. 11 days; P < .001 for both). The 5-year liver-specific recurrence rates were similar between the laparoscopic and hybrid groups (P = .270) and between the laparoscopic and open groups (P = .391).

Study details: The data come from a retrospective study including 647 patients who underwent simultaneous surgery for primary CRC and synchronous liver metastases and were categorized into the laparoscopic (n = 42) vs. hybrid (n = 81) and laparoscopic (n = 48) vs. open (n = 136) group sets after propensity score matching.

Disclosures: The study received no financial support. The authors declared no conflicts of interest.

Source: Lim H-K et al. Outcomes of simultaneous laparoscopic, hybrid, and open resection in colorectal cancer with synchronous liver metastases: a propensity score-matched study. Sci Rep. 2022;12:8867 (May 25). Doi: 10.1038/s41598-022-12372-5

Key clinical point: Compared with regorafenib, raltitrexed plus S-1 (RS) prolonged overall survival without causing unmanageable adverse effects in patients with metastatic colorectal cancer (mCRC) who did not respond to previous standard treatments.

Major finding: Patients receiving RS vs. regorafenib had a significantly longer overall survival (13.3 vs. 10.0 months; P = .02). Adverse events were well tolerated in both the groups.

Study details: The findings are from a real-world, retrospective cohort study including 187 adult patients with mCRC who received RS or regorafenib after the failure of ≥2 standard treatments and were propensity score-matched to form 78 pairs.

Disclosures: This study was sponsored by the Sichuan Science and Technology Department Key Research and Development Project, among others. The authors declared no conflicts of interest.

Source: Zhou Y-W et al. Efficacy and safety of raltitrexed plus S-1 versus regorafenib in patients with refractory metastatic colorectal cancer: A real-world propensity score matching study. Therap Adv Gastroenterol. 2022 (May 18). Doi: 10.1177/17562848221098246

Key clinical point: Compared with regorafenib, raltitrexed plus S-1 (RS) prolonged overall survival without causing unmanageable adverse effects in patients with metastatic colorectal cancer (mCRC) who did not respond to previous standard treatments.

Major finding: Patients receiving RS vs. regorafenib had a significantly longer overall survival (13.3 vs. 10.0 months; P = .02). Adverse events were well tolerated in both the groups.

Study details: The findings are from a real-world, retrospective cohort study including 187 adult patients with mCRC who received RS or regorafenib after the failure of ≥2 standard treatments and were propensity score-matched to form 78 pairs.

Disclosures: This study was sponsored by the Sichuan Science and Technology Department Key Research and Development Project, among others. The authors declared no conflicts of interest.

Source: Zhou Y-W et al. Efficacy and safety of raltitrexed plus S-1 versus regorafenib in patients with refractory metastatic colorectal cancer: A real-world propensity score matching study. Therap Adv Gastroenterol. 2022 (May 18). Doi: 10.1177/17562848221098246

Key clinical point: Compared with regorafenib, raltitrexed plus S-1 (RS) prolonged overall survival without causing unmanageable adverse effects in patients with metastatic colorectal cancer (mCRC) who did not respond to previous standard treatments.

Major finding: Patients receiving RS vs. regorafenib had a significantly longer overall survival (13.3 vs. 10.0 months; P = .02). Adverse events were well tolerated in both the groups.

Study details: The findings are from a real-world, retrospective cohort study including 187 adult patients with mCRC who received RS or regorafenib after the failure of ≥2 standard treatments and were propensity score-matched to form 78 pairs.

Disclosures: This study was sponsored by the Sichuan Science and Technology Department Key Research and Development Project, among others. The authors declared no conflicts of interest.

Source: Zhou Y-W et al. Efficacy and safety of raltitrexed plus S-1 versus regorafenib in patients with refractory metastatic colorectal cancer: A real-world propensity score matching study. Therap Adv Gastroenterol. 2022 (May 18). Doi: 10.1177/17562848221098246