Medical Grand Rounds

Stephen P. Emery, MD
Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation

Address: Stephen P. Emery, MD, Department of Obstetrics and Gynecology, M66, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Stephen P. Emery, MD
Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation

Address: Stephen P. Emery, MD, Department of Obstetrics and Gynecology, M66, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Stephen P. Emery, MD
Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation

Address: Stephen P. Emery, MD, Department of Obstetrics and Gynecology, M66, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Joseph P. Broderick, MD
Professor and Chair, Department of Neurology, University of Cincinnati

Address: Joseph P. Broderick, MD, Professor and Chair of Neurology, University of Cincinnati Medical Center, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0525

The author has indicated that he has received grant or research support from and serves as a consultant for the Novo Nordisk corporation.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Joseph P. Broderick, MD
Professor and Chair, Department of Neurology, University of Cincinnati

Address: Joseph P. Broderick, MD, Professor and Chair of Neurology, University of Cincinnati Medical Center, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0525

The author has indicated that he has received grant or research support from and serves as a consultant for the Novo Nordisk corporation.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Joseph P. Broderick, MD
Professor and Chair, Department of Neurology, University of Cincinnati

Address: Joseph P. Broderick, MD, Professor and Chair of Neurology, University of Cincinnati Medical Center, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0525

The author has indicated that he has received grant or research support from and serves as a consultant for the Novo Nordisk corporation.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Mark A. Crowther, MD
Division of Hematology, McMaster University, Hamilton, Ontario

Address: Mark A. Crowther, MD, Division of Hematology, McMaster University, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Mark A. Crowther, MD
Division of Hematology, McMaster University, Hamilton, Ontario

Address: Mark A. Crowther, MD, Division of Hematology, McMaster University, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Mark A. Crowther, MD
Division of Hematology, McMaster University, Hamilton, Ontario

Address: Mark A. Crowther, MD, Division of Hematology, McMaster University, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Amir K. Jaffer, MD
Medical Director, the IMPACT Center and The Anticoagulation Clinic, Section of Hospital Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

The author has indicated that he has received grant or research suport from the Astra Zeneca corporation, serves as a consultant for the Sanofi-Aventis corporation, and is on the speaker’s bureau of the Sanofi-Aventis corporation.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Amir K. Jaffer, MD
Medical Director, the IMPACT Center and The Anticoagulation Clinic, Section of Hospital Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

The author has indicated that he has received grant or research suport from the Astra Zeneca corporation, serves as a consultant for the Sanofi-Aventis corporation, and is on the speaker’s bureau of the Sanofi-Aventis corporation.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Amir K. Jaffer, MD
Medical Director, the IMPACT Center and The Anticoagulation Clinic, Section of Hospital Medicine, Department of General Internal Medicine, The Cleveland Clinic Foundation

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

The author has indicated that he has received grant or research suport from the Astra Zeneca corporation, serves as a consultant for the Sanofi-Aventis corporation, and is on the speaker’s bureau of the Sanofi-Aventis corporation.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from presentations at The Cleveland Clinic Foundation. They are approved by the author but are not peer-reviewed.

Wendy Armstrong, MD
Department of Infectious Disease, The Cleveland Clinic Foundation

Leonard Calabrese, DO
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation

Alan J. Taege, MD
Department of Infectious Disease, The Cleveland Clinic

Address: Alan J. Taege, MD, Department of Infectious Disease, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Dr. Taege has indicated that he serves as a consultant for the Glaxo, BMS, Pfizer, and Merck corporations, is on the speakers’ bureaus of the Glaxo, BMS, and Roche corporations, and is a major stock shareholder in the Amgen corporation.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Wendy Armstrong, MD
Department of Infectious Disease, The Cleveland Clinic Foundation

Leonard Calabrese, DO
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation

Alan J. Taege, MD
Department of Infectious Disease, The Cleveland Clinic

Address: Alan J. Taege, MD, Department of Infectious Disease, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Dr. Taege has indicated that he serves as a consultant for the Glaxo, BMS, Pfizer, and Merck corporations, is on the speakers’ bureaus of the Glaxo, BMS, and Roche corporations, and is a major stock shareholder in the Amgen corporation.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Wendy Armstrong, MD
Department of Infectious Disease, The Cleveland Clinic Foundation

Leonard Calabrese, DO
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation

Alan J. Taege, MD
Department of Infectious Disease, The Cleveland Clinic

Address: Alan J. Taege, MD, Department of Infectious Disease, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Dr. Taege has indicated that he serves as a consultant for the Glaxo, BMS, Pfizer, and Merck corporations, is on the speakers’ bureaus of the Glaxo, BMS, and Roche corporations, and is a major stock shareholder in the Amgen corporation.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Brian F. Mandell, MD, PhD
Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Vice Chairman of Medicine for Educational Affairs, The Cleveland Clinic Foundation; Editor-in-Chief, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Division of Education, NA20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Oh 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Vice Chairman of Medicine for Educational Affairs, The Cleveland Clinic Foundation; Editor-in-Chief, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Division of Education, NA20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Oh 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Vice Chairman of Medicine for Educational Affairs, The Cleveland Clinic Foundation; Editor-in-Chief, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Division of Education, NA20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Oh 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Sharon K. Inouye, MD, MPH
Department of Internal Medicine, Yale University School of Medicine

Address: Sharon K Inouye, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street (DC013K), PO Box 208025, New Haven, CT 06520

This paper was adapted from a presentation given by Dr. Inouye as Visiting Professor Pro Tempore, Department of Medicine, Case Western Reserve University and The Cleveland Clinic Educational Foundation.

Medical Grand Rounds articles are approved by the author but are not peer-reviewed.

Sharon K. Inouye, MD, MPH
Department of Internal Medicine, Yale University School of Medicine

Address: Sharon K Inouye, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street (DC013K), PO Box 208025, New Haven, CT 06520

This paper was adapted from a presentation given by Dr. Inouye as Visiting Professor Pro Tempore, Department of Medicine, Case Western Reserve University and The Cleveland Clinic Educational Foundation.

Medical Grand Rounds articles are approved by the author but are not peer-reviewed.

Sharon K. Inouye, MD, MPH
Department of Internal Medicine, Yale University School of Medicine

Address: Sharon K Inouye, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street (DC013K), PO Box 208025, New Haven, CT 06520

This paper was adapted from a presentation given by Dr. Inouye as Visiting Professor Pro Tempore, Department of Medicine, Case Western Reserve University and The Cleveland Clinic Educational Foundation.

Medical Grand Rounds articles are approved by the author but are not peer-reviewed.

Judith White, MD, PhD
Program of Vestibular and Balance Disorders, Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation

Address: Judith White, MD, PhD, Department of Otolaryngology and Communicative Disorders, A71, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Judith White, MD, PhD
Program of Vestibular and Balance Disorders, Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation

Address: Judith White, MD, PhD, Department of Otolaryngology and Communicative Disorders, A71, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Judith White, MD, PhD
Program of Vestibular and Balance Disorders, Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation

Address: Judith White, MD, PhD, Department of Otolaryngology and Communicative Disorders, A71, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Brian F. Mandell, MD, PhD
Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine

Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Michael E. Weinblatt, MD
Co-director of Clinical Rheumatology, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School, Boston, MA

Address: Michael E. Weinblatt, MD, Brigham and Women’s Hospital, Rheumatology-Immunology-Allergy, Arthritis Center, 75 Francis Street, Boston, MA 02115

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

The author has indicated that he has received grant or research support from the Abbott, Amgen, Bristol-Myers Squibb, and Millennium companies and has served as a consultant for Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genentech, Merck, Millennium, Roche, TAP, and Wyeth.

This paper discusses therapies that are investigational or are not approved by the US Food and Drug Administration for the use under discussion.

Michael E. Weinblatt, MD
Co-director of Clinical Rheumatology, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School, Boston, MA

Address: Michael E. Weinblatt, MD, Brigham and Women’s Hospital, Rheumatology-Immunology-Allergy, Arthritis Center, 75 Francis Street, Boston, MA 02115

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

The author has indicated that he has received grant or research support from the Abbott, Amgen, Bristol-Myers Squibb, and Millennium companies and has served as a consultant for Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genentech, Merck, Millennium, Roche, TAP, and Wyeth.

This paper discusses therapies that are investigational or are not approved by the US Food and Drug Administration for the use under discussion.

Michael E. Weinblatt, MD
Co-director of Clinical Rheumatology, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School, Boston, MA

Address: Michael E. Weinblatt, MD, Brigham and Women’s Hospital, Rheumatology-Immunology-Allergy, Arthritis Center, 75 Francis Street, Boston, MA 02115

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

The author has indicated that he has received grant or research support from the Abbott, Amgen, Bristol-Myers Squibb, and Millennium companies and has served as a consultant for Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genentech, Merck, Millennium, Roche, TAP, and Wyeth.

This paper discusses therapies that are investigational or are not approved by the US Food and Drug Administration for the use under discussion.