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Novel liver-targeting drug offers hope for AAT deficiency
The investigational drug fazirsiran improved important liver parameters associated with alpha-1-antitrypsin deficiency.
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New onset-depression after RA diagnosis raises mortality risk ‘more than sixfold’
Developing depression after a diagnosis of rheumatoid arthritis substantially increased the risk for death over 10 years in a large Danish...
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Diagnostic axSpA MRI features differ in men and women
The cohort study of German patients with and without the disease found no major sex-specific differences for erosion and bone marrow edema but did...
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Deucravacitinib and orelabrutinib perform well in early lupus trials
Disease activity was reduced by treatment with either of the novel investigational agents in two separate early clinical trials, with further...
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Methotrexate enhances pegloticase response in uncontrolled gout
Greater efficacy and fewer infusion reactions seen with methotrexate-pegloticase combination than pegloticase alone in the placebo-controlled...
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Izokibep improves multiple psoriatic arthritis symptoms in phase 2 study
Greater percentages of patients treated with one of two doses of the novel IL-17 blocker achieved an ACR50 response versus placebo.
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Updated EULAR recommendations for AAV include new drugs, practices
Avacopan and mepolizumab feature in new European recommendations for managing antineutrophil cytoplasmic antibody–associated vasculitis.
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‘Shielding’ status provides best indicator of COVID-19 mortality in U.K. arthritis population
Shielding status was the highest ranked of all the risk factors identified for early mortality from COVID-19.
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Myositis guidelines aim to standardize adult and pediatric care
These are the first guidelines on how to manage adult and pediatric patients with idiopathic inflammatory myopathies (IIM).
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Reduced-frequency methotrexate monitoring causes no harm
Laboratory blood test results were similar despite moving from once every month to about once every 3 months or about once every 5 months during...
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Use of bone densitometry to grade hip OA could be boon to diagnosis, prognosis
A novel, semi-automated scoring system enables dual energy x-ray absorptiometry scans of the hip to be graded and provide useful clinical...
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Lupus may lead to worse stroke outcomes for women, but not men
Women with systemic lupus erythematosus (SLE) were 20% more likely to have a prolonged hospital stay and 28% less likely to have a routine home...
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IBD risk ‘uncertain’ in biologic-treated AxSpA patients
“Enormous uncertainty” surrounds the risk of inflammatory bowel disease associated with biologic treatment in patients with axial...
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Wearable sensors deemed reliable for home gait assessment in knee OA
Remote use of wearable gait sensors appears reliable but yields results slightly different from those achieved in the laboratory, researchers from...
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OARSI sets sights on classifying early-stage knee OA
“Early-stage knee OA classification criteria, we believe are critically required,” Gillian Hawker, MD, MSc, said at the OARSI 2022 World Congress...