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Noncardiac mortality is not increased by revascularization in a meta-analysis: New data refute recent study
Contrary to previous findings, no increased risk of noncardiac mortality was associated with revascularization in a meta-analysis of 18 trials.
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ECMO signals benefit for cardiogenic shock after MI in halted trial
Although based on small numbers in a halted trial, ECMO was associated with reduced mortality for PCI patients in MI-related cardiogenic shock,...
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Noninferior to DES, novel bioadaptable stent may improve target vessel physiology
By restoring blood vessel hemodynamics, a novel bioadaptable – as opposed to bioabsorbable – coronary stent might change long-term outcomes,...
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Transcatheter tricuspid valve repair in real-world setting replicates trials
Two transcatheter tricuspid valve repair systems in the real world reflect safety and efficacy seen in trials.
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Evidence of TAVR benefit extends to cardiogenic shock
Patients in cardiogenic shock should not be excluded from transcatheter aortic valve replacement, despite some early adverse event risk, new...
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Redo-TAVR in U.S. database yields good news: Outcomes rival first intervention
A large transcatheter aortic valve transplant (TAVR) database shows a second procedure performs about as well as native TAVR.
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Stroke scale cutoff might not be ideal guide for ordering CTA and detecting large vessel occlusions
If the goal is not to miss any LVOs, there is no NIHSS score below which these do not occur.
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Teriflunomide delays MS symptoms in radiologically isolated syndrome
The data support the theory that treatment should begin early in patients with a high likelihood of developing symptomatic MS on the basis of...
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Novel levodopa delivery system promises continuous dosing without surgery or pump
The experimental device is designed to deliver levodopa and carbidopa into the mouth through a micropump within a wearable retainer.
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Machine learning can predict primary progressive MS progression
The model, which is clinically viable even as it is still evolving, predicts disability progression with an accuracy of approximately 70%.
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Therapy to reverse muscle dystrophies shows promise
Interim study data showed rapid reductions in multiple biomarkers of muscle injury, reductions in anti-inflammatory markers, proteomic changes...
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Phase 3 study of new levodopa/carbidopa delivery system meets all efficacy endpoints
The subcutaneous infusion system improved ON time without troublesome dyskinesias while improving symptoms according to ratings from both patients...
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Explanation proposed for long-COVID symptoms in the CNS
In the case of persistent neurologic symptoms after COVID, antibodies produced for previously encountered coronaviruses rather than for SARS-CoV2...
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JAK inhibitor ivarmacitinib shows efficacy for atopic dermatitis in a pivotal trial
The co-primary endpoints were change in IGA and EASI scores at 16 weeks, and both improved rapidly, showing statistical significance relative to...
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New data forecast more oral PDE4 inhibitors for psoriasis
The phase 2b data suggest that the drug, called orismilast, “is a potential new addition to the psoriasis armamentarium,” said Lars E. French, MD...