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Genes can stop onset of AML, study suggests
Image by Lance Liotta
Two genes can stop the development of acute myeloid leukemia (AML), according to research published in the Journal of Experimental Medicine.
The work suggests that Hif-1α and Hif-2α work together to stop the formation of leukemic stem cells, and blocking either Hif-2α or both genes
accelerates AML development.
Investigators said these findings are surprising because previous research suggested that blocking Hif-1α or Hif-2α might stop AML progression.
But their study suggests that therapies designed to block these genes might worsen AML or at least have no impact on the disease.
Conversely, designing new therapies that promote the activity of Hif-1α and Hif-2α could help treat AML or stop relapse after chemotherapy.
“Our discovery that Hif-1α and Hif-2α molecules act together to stop leukemia development is a major milestone in our efforts to combat leukemia,” said study author Kamil R. Kranc, DPhil, of the University of Edinburgh in Scotland.
“We now intend to harness this knowledge to develop curative therapies that eliminate leukemic stem cells, which are the underlying cause of AML.”
Image by Lance Liotta
Two genes can stop the development of acute myeloid leukemia (AML), according to research published in the Journal of Experimental Medicine.
The work suggests that Hif-1α and Hif-2α work together to stop the formation of leukemic stem cells, and blocking either Hif-2α or both genes
accelerates AML development.
Investigators said these findings are surprising because previous research suggested that blocking Hif-1α or Hif-2α might stop AML progression.
But their study suggests that therapies designed to block these genes might worsen AML or at least have no impact on the disease.
Conversely, designing new therapies that promote the activity of Hif-1α and Hif-2α could help treat AML or stop relapse after chemotherapy.
“Our discovery that Hif-1α and Hif-2α molecules act together to stop leukemia development is a major milestone in our efforts to combat leukemia,” said study author Kamil R. Kranc, DPhil, of the University of Edinburgh in Scotland.
“We now intend to harness this knowledge to develop curative therapies that eliminate leukemic stem cells, which are the underlying cause of AML.”
Image by Lance Liotta
Two genes can stop the development of acute myeloid leukemia (AML), according to research published in the Journal of Experimental Medicine.
The work suggests that Hif-1α and Hif-2α work together to stop the formation of leukemic stem cells, and blocking either Hif-2α or both genes
accelerates AML development.
Investigators said these findings are surprising because previous research suggested that blocking Hif-1α or Hif-2α might stop AML progression.
But their study suggests that therapies designed to block these genes might worsen AML or at least have no impact on the disease.
Conversely, designing new therapies that promote the activity of Hif-1α and Hif-2α could help treat AML or stop relapse after chemotherapy.
“Our discovery that Hif-1α and Hif-2α molecules act together to stop leukemia development is a major milestone in our efforts to combat leukemia,” said study author Kamil R. Kranc, DPhil, of the University of Edinburgh in Scotland.
“We now intend to harness this knowledge to develop curative therapies that eliminate leukemic stem cells, which are the underlying cause of AML.”
Group finds inconsistencies in genome sequencing procedures
Photo courtesy of NIGMS
Researchers say they have identified substantial differences in the procedures and quality of cancer genome sequencing between sequencing centers.
And this led to dramatic discrepancies in the number and types of somatic mutations detected when using the same cancer genome sequences for analysis.
The group’s study involved 83 researchers from 78 institutions participating in the International Cancer Genomics Consortium (ICGC).
The ICGC is an international effort to establish a comprehensive description of genomic, transcriptomic, and epigenomic changes in 50 different tumor types and/or subtypes that are thought to be of clinical and societal importance across the globe.
The consortium is characterizing more than 25,000 cancer genomes and carrying out 78 projects supported by different national and international funding agencies.
For the current project, which was published in Nature Communications, researchers studied a patient with chronic lymphocytic leukemia and a patient with medulloblastoma.
The team analyzed the entire tumor genome of each patient and compared it to the normal genome of the same patient to decipher the molecular causes for these cancers.
The researchers said they saw “widely varying mutation call rates and low concordance among analysis pipelines.”
So they established a reference mutation dataset to assess analytical procedures. They said this “gold-set” reference database has helped the ICGC community improve procedures for identifying more true somatic mutations in cancer genomes and making fewer false-positive calls.
“The findings of our study have far-reaching implications for cancer genome analysis,” said Ivo Gut, of Centro Nacional de Analisis Genómico in Barcelona, Spain.
“We have found many inconsistencies in both the sequencing of cancer genomes and the data analysis at different sites. We are making our findings available to the scientific and diagnostic community so that they can improve their systems and generate more standardized and consistent results.”
Photo courtesy of NIGMS
Researchers say they have identified substantial differences in the procedures and quality of cancer genome sequencing between sequencing centers.
And this led to dramatic discrepancies in the number and types of somatic mutations detected when using the same cancer genome sequences for analysis.
The group’s study involved 83 researchers from 78 institutions participating in the International Cancer Genomics Consortium (ICGC).
The ICGC is an international effort to establish a comprehensive description of genomic, transcriptomic, and epigenomic changes in 50 different tumor types and/or subtypes that are thought to be of clinical and societal importance across the globe.
The consortium is characterizing more than 25,000 cancer genomes and carrying out 78 projects supported by different national and international funding agencies.
For the current project, which was published in Nature Communications, researchers studied a patient with chronic lymphocytic leukemia and a patient with medulloblastoma.
The team analyzed the entire tumor genome of each patient and compared it to the normal genome of the same patient to decipher the molecular causes for these cancers.
The researchers said they saw “widely varying mutation call rates and low concordance among analysis pipelines.”
So they established a reference mutation dataset to assess analytical procedures. They said this “gold-set” reference database has helped the ICGC community improve procedures for identifying more true somatic mutations in cancer genomes and making fewer false-positive calls.
“The findings of our study have far-reaching implications for cancer genome analysis,” said Ivo Gut, of Centro Nacional de Analisis Genómico in Barcelona, Spain.
“We have found many inconsistencies in both the sequencing of cancer genomes and the data analysis at different sites. We are making our findings available to the scientific and diagnostic community so that they can improve their systems and generate more standardized and consistent results.”
Photo courtesy of NIGMS
Researchers say they have identified substantial differences in the procedures and quality of cancer genome sequencing between sequencing centers.
And this led to dramatic discrepancies in the number and types of somatic mutations detected when using the same cancer genome sequences for analysis.
The group’s study involved 83 researchers from 78 institutions participating in the International Cancer Genomics Consortium (ICGC).
The ICGC is an international effort to establish a comprehensive description of genomic, transcriptomic, and epigenomic changes in 50 different tumor types and/or subtypes that are thought to be of clinical and societal importance across the globe.
The consortium is characterizing more than 25,000 cancer genomes and carrying out 78 projects supported by different national and international funding agencies.
For the current project, which was published in Nature Communications, researchers studied a patient with chronic lymphocytic leukemia and a patient with medulloblastoma.
The team analyzed the entire tumor genome of each patient and compared it to the normal genome of the same patient to decipher the molecular causes for these cancers.
The researchers said they saw “widely varying mutation call rates and low concordance among analysis pipelines.”
So they established a reference mutation dataset to assess analytical procedures. They said this “gold-set” reference database has helped the ICGC community improve procedures for identifying more true somatic mutations in cancer genomes and making fewer false-positive calls.
“The findings of our study have far-reaching implications for cancer genome analysis,” said Ivo Gut, of Centro Nacional de Analisis Genómico in Barcelona, Spain.
“We have found many inconsistencies in both the sequencing of cancer genomes and the data analysis at different sites. We are making our findings available to the scientific and diagnostic community so that they can improve their systems and generate more standardized and consistent results.”
Readmissions in Medicaid Beneficiaries
Hospital readmissions that occur within 30 days of discharge are an important measure for assessing performance of the healthcare system and the quality of patient care.[1, 2] According to the Healthcare Cost and Utilization Project (HCUP), there were approximately 3.3 million adults with all‐cause 30‐day readmissions in the United States in 2011, incurring nearly $41.3 billion in hospital costs.[3] Reducing 30‐day readmissions has become a priority for payers, providers, and policymakers seeking to achieve improved quality of care at lower costs.
The implementation of the Affordable Care Act (ACA) provided the Centers for Medicare & Medicaid Services (CMS) statutory authority under the Hospital Readmissions Reduction Program to reduce payments for certain hospital readmissions that it deemed avoidable.[4] Although initial focus was on Medicare readmissions related to heart failure, myocardial infarction, and pneumonia, CMS is now considering expanding the list beyond the 3 conditions covered by the program.[4, 5] Therefore, it is important to understand major risk factors for readmissions in beneficiaries with chronic conditions.
Medicaid consists of the largest number of beneficiaries among all payers in the United States, with approximately 62 million beneficiaries in 2013.[5] The Medicaid population is further expected to increase with the coverage expansions under the ACA. In addition, the state Medicaid programs incur an estimated $374 billion in healthcare expenditures and provide healthcare services to the vulnerable, indigent, and disabled. It is estimated that 61% of adult Medicaid beneficiaries have chronic or disabling conditions that place them at an increased risk of hospitalization.[6] A series of HCUP statistical briefs reported several findings. First, Medicaid all‐cause readmission rates were comparable with Medicare but double the rate of private insurance.[7] Second, for readmissions following nonsurgical hospitalizations, 30‐day Medicaid readmission rates were higher than Medicare and private insurance for both acute and chronic conditions.[1] The effects of such costly utilization patterns, for this large and growing population necessitates heightened attention under healthcare reform.
The balance between hospital efficiency and quality of care is another crucial aspect for our healthcare system. However, length of stay (LOS), a proxy marker for efficiency, may conflict with hospital readmission rates, an indicator of quality. Further, CMS plans to bundle 30‐day readmission rates to reimbursement for the index hospitalization.[8]
The effect of LOS on readmission rates is complex, and previous studies have provided conflicting data regarding the relationship between LOS and subsequent readmission risk. Some indicate that shorter LOS is associated with a higher risk of readmission,[8, 9] whereas others suggest that extended LOS is associated with a higher risk of readmission.[10, 11, 12] However, most research on readmissions has focused on Medicare beneficiaries.[11, 13, 14] The readmission patterns of Medicaid beneficiaries differ from those of the geriatric Medicare beneficiaries, from a clinical and socioeconomic perspective. Considering the importance of 30‐day readmission for payers and policy makers, there is a need to understand the role of LOS and implications for treatment and management strategies.
Our study examined the association between index hospitalization characteristics (LOS and reason for admission) and all‐cause 30‐day readmission risk in fee‐for‐service high‐risk Medicaid beneficiaries. The study is limited to patients with selected chronic conditions and examines the differentiating factors within this high‐risk population. For the purpose of our study, variables were selected based on a priori knowledge and Andersen's behavioral model of health service utilization. This model suggests that potential health service use is determined by interactions among predisposing (demographics, index hospitalization characteristics), enabling (county level [eg, socioeconomic status]), and need (health status) characteristics of individuals and also the healthcare systems in the communities where they reside.[15]
METHODS
Study Design
A retrospective cohort approach was used with baseline and follow‐up periods. The baseline period was defined as the admission date of the index hospitalization (first observed hospitalization) between January 1, 2007 and December 31, 2007. Patients were followed for 180 days after discharge date of the associated index hospitalization.
Data Source
Medicaid administrative claims files from California, Illinois, New York, and Texas, between 2006 and 2008, were used. The personal summary file included information on demographics, Medicaid enrollment, and eligibility status. Outpatient and Inpatient files included claims for services provided in ambulatory and inpatient settings and contained International Classification of Diseases, 9th Revision, Clinical Modification codes. Information on county‐level characteristics were obtained from the 2009 Area Health Resource File (AHRF), which was linked to Medicaid administrative claims files using state and county codes where each beneficiary resided.
Study Population
The study population consisted of nonelderly (2164 years old) fee‐for‐service Medicaid‐only beneficiaries with selected chronic conditions and continuous enrollment during baseline and follow‐up period (Figure 1). Analyses were restricted to those who had at least 1 inpatient admission in 2007 and were conducted at the person‐level.

For the purpose of this study, Medicaid beneficiaries with 19 chronic conditions were selected: asthma, arthritis, cardiac arrhythmias, coronary artery disease, cancer, congestive heart failure, chronic kidney disease, chronic obstructive pulmonary disease, dementia, diabetes, hypertension, hyperlipidemia, hepatitis, human immunodeficiency virus osteoporosis, stroke, depression, schizophrenia, and substance use disorders. These conditions were identified based on the strategic framework developed and adopted by the Department of Health and Human Services for research, policy, program, and practice.[16]
Dependent Variable
Individuals were categorized into 2 groups, those with and without all‐cause 30‐day readmission. All‐cause 30‐day readmission was identified as subsequent hospitalization within 30 days of discharge date of the index hospitalization.
Key Independent Variables
These were index hospitalization characteristics, where LOS was the primary independent variable, reason for admission was the secondary independent variable, and month of index hospitalization (included to control for potential seasonal effect).
Other Independent Variables
Patient‐level characteristics included demographics (age, gender, and race/ethnicity) and Medicaid eligibility status (cash and medical need). Primary care access included continuity of care measured using a previously published continuity index (Modified Modified Continuity Index) and coordination of care, measured as primary care visit within 14 days of discharge date. Healthcare utilization was measured as an emergency room visit within 6 months prior to the index hospitalization.
Variables accounting for county socioeconomic status included educational attainment, per capita income, employment rate, poverty level, and metropolitan statistical area. Variables related to availability of providers and healthcare facilities were AHRF designations for primary/mental healthcare shortage areas, presence of federally qualified health centers, rural health centers, and community mental health centers. Hospital and primary care provider density was defined as total number of hospitals or primary care providers per 100,000 individuals, respectively.
Statistical Techniques
2 tests of independence were used for categorical variables and t tests for continuous variables to determine group differences in patient‐level and county‐level characteristics and all‐cause 30‐day readmission. Multilevel logistic regression models, which accounted for beneficiaries nested within counties, were used to examine the association between all‐cause 30‐day readmission and index hospitalization characteristics. The reference group for the dependent variable was no 30‐day readmission. Model 1 controlled for only patient‐level characteristics. Model 2 controlled for both patient‐level and county‐level characteristics. In both models, county was specified as a random intercept using the GLIMMIX procedure. All analyses were conducted using SAS version 9.3 (SAS Inc., Cary, NC).
RESULTS
After the exclusion criteria, there were 15,806 Medicaid beneficiaries with selected chronic conditions and at least 1 inpatient encounter in 2007. Overall, 16.7% experienced all‐cause 30‐day readmissions. A description of the study population and unadjusted associations between independent variables and all‐cause 30‐day readmission are presented in Table 1.
Variables | 30‐Day Readmission, 2,633 (16.7%) | No 30‐Day Readmission, 13,173 (83.3%) | Significance |
---|---|---|---|
| |||
Demographic and Medicaid eligibility characteristics | |||
Gender, N (%) | * | ||
Female | 1,715 (65.1%) | 9,274 (70.4%) | |
Male | 918 (34.9%) | 3,899 (29.6%) | |
Age group, N (%) | * | ||
2124 years | 301 (11.4%) | 1,675 (12.7%) | |
2534 years | 567 (21.5%) | 3,578 (27.2%) | |
3544 years | 517 (19.6%) | 2,498 (19.0%) | |
4554 years | 673 (25.6%) | 2,971 (22.6%) | |
5564 years | 575 (21.8%) | 2,451 (18.6%) | |
Race/ethnicity, N (%) | * | ||
Caucasian | 847 (32.2%) | 3,831 (29.1%) | |
African American | 988 (37.5%) | 4,270(32.4%) | |
Hispanic | 608 (23.1%) | 4,245 (32.2%) | |
Asian/AI/PI | 39 (1.5%) | 169 (1.3%) | |
Other | 151 (5.7%) | 658 (5.0%) | |
Cash eligibility, N (%) | 1,529 (58.1%) | 6,666 (50.6%) | * |
Medical need eligibility, N (%) | 876 (33.3%) | 3769 (28.6%) | * |
Index hospitalization characteristics | |||
Length of stay, mean [SD] | 6.62 [9.09] | 4.29 [6.35] | * |
Chronic conditions at admission, N (%) | |||
Arthritis/osteoporosis | 99 (3.8%) | 464 (3.5%) | |
Cancer | 134 (5.1%) | 429 (3.3%) | * |
Cardiovascular conditions | 995 (37.8%) | 3,733 (28.3%) | * |
COPD/asthma | 541 (20.5%) | 2,197 (16.7%) | * |
Diabetes | 575 (21.8%) | 2,103 (16.0%) | * |
HIV/hepatitis | 305 (11.6%) | 1,185 (9.0%) | * |
Mental health conditions | 1,491 (56.6%) | 4,352 (33.0%) | * |
Season of readmission, N (%) | * | ||
Spring | 730 (27.7%) | 3,944 (29.9%) | |
Summer | 401 (15.2%) | 2,332 (17.7%) | |
Fall | 211 (8.0%) | 1,605 (12.2%) | |
Winter | 1,291 (49.0%) | 5,292 (40.2%) | |
Primary care access, N (%) | |||
Coordination of primary care | 326 (12.4%) | 1,747 (13.3%) | |
Continuity of primary care, N (%) | |||
Complete care continuity | 349 (13.3%) | 1,764 (13.4%) | |
Some care continuity | 634 (24.1%) | 2,960 (22.5%) | |
No care continuity | 1650 (62.7%) | 8,449 (64.1%) | |
Healthcare utilization, N (%) | |||
Emergency room visit | 893 (33.9%) | 4,449 (33.8%) | |
County‐level characteristics | |||
Metropolitan status, N (%) | |||
Nonmetro | 267 (10.1%) | 1,285 (9.8%) | |
Metro | 2,366 (89.9%) | 11,888 (90.2%) | |
Primary care shortage area, N (%) | |||
Whole county | 2,034 (77.3%) | 10,147 (77.0%) | |
Part county | 429 (16.3%) | 2,312 (17.6%) | |
No shortage | 170 (6.5%) | 714 (5.4%) | |
Mental healthcare shortage area, N (%) | |||
Whole county | 2,015 (76.5%) | 9,925 (75.3%) | |
Part county | 388 (14.7%) | 2,242 (17.0%) | |
No shortage | 230 (8.7%) | 1,006 (7.6%) | |
CMHC, mean [SD] | 0.81 [1.23] | 0.94 [1.24] | * |
Rural health center, mean [SD] | 0.62 [3.03] | 1.06 [4.41] | * |
FQHC, mean [SD] | 37.69 [44.31] | 37.78 [42.98] | |
Education rate, 4+ years, mean [SD] | 25.39 [10.98] | 23.77 [10.51] | * |
Unemployment rate, mean [SD] | 4.57 [0.71] | 4.67 [0.90] | * |
% Below poverty level, mean [SD] | 15.11 [3.73] | 15.06 [3.80] | |
Per capita income (US dollars), mean [SD] | 58,761.96 [33,697.42] | 54,029.16 [31,265.86] | * |
Nonfederal PCP density, mean [SD] | 307.10 [192.29] | 279.97 [179.22] | * |
Hospital density, mean [SD] | 1.74 [1.37] | 1.65 [1.14] | * |
Multilevel logistic regressions of all‐cause 30‐day readmissions are summarized in Table 2. Beneficiaries with longer LOS had significantly higher odds of 30‐day readmission. In addition, presence of cancer, cardiovascular conditions, diabetes, and mental health conditions at index hospitalization significantly increased the odds of readmission. In addition, beneficiaries with cash or medical need eligibility had significantly higher odds of 30‐day readmission.
AOR | 95% CI | Significance | |
---|---|---|---|
| |||
Length of stay | 1.03 | [1.031.04] | * |
Chronic conditions at admission | |||
Arthritis/osteoporosis | 0.90 | [0.721.13] | |
Cancer | 1.55 | [1.261.90] | * |
Cardiovascular conditions | 1.20 | [1.081.33] | * |
COPD/asthma | 1.01 | [0.901.12] | |
Diabetes | 1.23 | [1.101.39] | * |
HIV/hepatitis | 0.98 | [0.851.12] | |
Mental health conditions | 2.17 | [1.982.38] | * |
Season of readmission | |||
Spring | 0.79 | [0.710.88] | * |
Summer | 0.77 | [0.680.88] | * |
Fall | 0.58 | [0.490.68] | * |
Winter | Reference | ||
Cash eligibility | 1.14 | [1.011.27] | |
Medical need eligibility | 1.21 | [1.081.36] |
DISCUSSION
To the best of our knowledge, this is the first study examining patient‐level and county‐level characteristics associated with all‐cause 30‐day readmission in Medicaid beneficiaries with chronic conditions. In addition, our findings add to the nascent literature on readmissions among Medicaid beneficiaries, with findings discussed below.
LOS has been reported as a risk factor for readmission both in elderly and nonelderly populations.[11] Our findings indicate that longer LOS is associated with increased odds of 30‐day readmission, which could be attributed to severity of illness at index hospitalization.[10] This finding could be related to unmeasured clinical severity (our models account for some comorbidities) and socioeconomic issues (as noted in the introduction). This may have implications for discharge planning efforts and focusing on chronic disease management, which has previously shown to be effective in reducing readmissions.[17] Our findings suggest 30‐day readmissions can be predicted using variables that are readily available, few in number, and simple to incorporate in discharge planning. Comprehensive discharge planning which takes into account chronic conditions and index hospitalization characteristics may help organize postdischarge services, including coordination of care with physicians, medication reconciliation, follow‐up care, and appropriate self‐management for chronic conditions.
Our findings of increased risk of 30‐day hospital readmissions as well as longer LOS among Medicaid beneficiaries with cancer, cardiovascular conditions, diabetes, and mental health conditions at index hospitalization suggests that patient complexity/poor health status increases the risk of readmission. A more focused approach in treatment of these diseases can help reduce readmissions. Integrated care management interventions after hospital discharge have been shown to reduce readmissions among those with heart disease; a coordinated care team including cardiologists, specialized nurses, and primary care physicians, and provision of integrated care following hospitalizations have shown benefit.[18, 19] Emerging models of delivery such as accountable care organizations and patient‐centered medical homes, which offer comprehensive, well‐coordinated primary care services, may be needed to reduce readmission among Medicaid beneficiaries with chronic health conditions. In this respect, 3 of the 4 states represented (California, New York, and Texas) are CMS Innovation Model partner states and are presently awardees of Medicaid Incentives for the Prevention of Chronic Disease state grants.[20] It remains to be seen whether such programs can reduce the high prevalence of readmissions in a Medicaid population.
Although our findings may have implications in reducing readmission risk, these results need to be interpreted in the light of study limitations. Our study was based on beneficiaries from only 4 states and cannot be generalized to the entire US Medicaid population. We also excluded individuals who were not enrolled in Medicaid health maintenance organizations. Given that less than one‐third of the population receives fee‐for‐service care in Medicaid, our study may have selection bias. Our study design utilized a retrospective cohort approach and cannot be used to establish causal relationships. Further, our study did not include adjustment for variables related to discharge planning or care coordination other than a primary care visit 14 days post discharge, which might influence the readmission risk of complex patients. Our study utilized data from administrative claims files.
Overall, our analyses revealed that patient complexities increased the risk of all‐cause 30‐day readmission for high‐risk Medicaid beneficiaries with chronic conditions, thus warranting the need for comprehensive care for those with chronic conditions. Programs designed to reduce the risk of 30‐day readmissions may need to focus on appropriate disease management and better coordinated care post hospitalization.
Disclosures
Research reported in this publication was supported by the Training Program in the Behavioral and Biomedical Sciences at West Virginia University, National Institute of General Medical Sciences grant number T32 GM08174, and the National Institute of General Medical Sciences of the National Institutes of Health under award number U54GM104942, and the Benedum Foundation. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analyses, decision to publish, or preparation of the manuscript.
Hospital readmissions that occur within 30 days of discharge are an important measure for assessing performance of the healthcare system and the quality of patient care.[1, 2] According to the Healthcare Cost and Utilization Project (HCUP), there were approximately 3.3 million adults with all‐cause 30‐day readmissions in the United States in 2011, incurring nearly $41.3 billion in hospital costs.[3] Reducing 30‐day readmissions has become a priority for payers, providers, and policymakers seeking to achieve improved quality of care at lower costs.
The implementation of the Affordable Care Act (ACA) provided the Centers for Medicare & Medicaid Services (CMS) statutory authority under the Hospital Readmissions Reduction Program to reduce payments for certain hospital readmissions that it deemed avoidable.[4] Although initial focus was on Medicare readmissions related to heart failure, myocardial infarction, and pneumonia, CMS is now considering expanding the list beyond the 3 conditions covered by the program.[4, 5] Therefore, it is important to understand major risk factors for readmissions in beneficiaries with chronic conditions.
Medicaid consists of the largest number of beneficiaries among all payers in the United States, with approximately 62 million beneficiaries in 2013.[5] The Medicaid population is further expected to increase with the coverage expansions under the ACA. In addition, the state Medicaid programs incur an estimated $374 billion in healthcare expenditures and provide healthcare services to the vulnerable, indigent, and disabled. It is estimated that 61% of adult Medicaid beneficiaries have chronic or disabling conditions that place them at an increased risk of hospitalization.[6] A series of HCUP statistical briefs reported several findings. First, Medicaid all‐cause readmission rates were comparable with Medicare but double the rate of private insurance.[7] Second, for readmissions following nonsurgical hospitalizations, 30‐day Medicaid readmission rates were higher than Medicare and private insurance for both acute and chronic conditions.[1] The effects of such costly utilization patterns, for this large and growing population necessitates heightened attention under healthcare reform.
The balance between hospital efficiency and quality of care is another crucial aspect for our healthcare system. However, length of stay (LOS), a proxy marker for efficiency, may conflict with hospital readmission rates, an indicator of quality. Further, CMS plans to bundle 30‐day readmission rates to reimbursement for the index hospitalization.[8]
The effect of LOS on readmission rates is complex, and previous studies have provided conflicting data regarding the relationship between LOS and subsequent readmission risk. Some indicate that shorter LOS is associated with a higher risk of readmission,[8, 9] whereas others suggest that extended LOS is associated with a higher risk of readmission.[10, 11, 12] However, most research on readmissions has focused on Medicare beneficiaries.[11, 13, 14] The readmission patterns of Medicaid beneficiaries differ from those of the geriatric Medicare beneficiaries, from a clinical and socioeconomic perspective. Considering the importance of 30‐day readmission for payers and policy makers, there is a need to understand the role of LOS and implications for treatment and management strategies.
Our study examined the association between index hospitalization characteristics (LOS and reason for admission) and all‐cause 30‐day readmission risk in fee‐for‐service high‐risk Medicaid beneficiaries. The study is limited to patients with selected chronic conditions and examines the differentiating factors within this high‐risk population. For the purpose of our study, variables were selected based on a priori knowledge and Andersen's behavioral model of health service utilization. This model suggests that potential health service use is determined by interactions among predisposing (demographics, index hospitalization characteristics), enabling (county level [eg, socioeconomic status]), and need (health status) characteristics of individuals and also the healthcare systems in the communities where they reside.[15]
METHODS
Study Design
A retrospective cohort approach was used with baseline and follow‐up periods. The baseline period was defined as the admission date of the index hospitalization (first observed hospitalization) between January 1, 2007 and December 31, 2007. Patients were followed for 180 days after discharge date of the associated index hospitalization.
Data Source
Medicaid administrative claims files from California, Illinois, New York, and Texas, between 2006 and 2008, were used. The personal summary file included information on demographics, Medicaid enrollment, and eligibility status. Outpatient and Inpatient files included claims for services provided in ambulatory and inpatient settings and contained International Classification of Diseases, 9th Revision, Clinical Modification codes. Information on county‐level characteristics were obtained from the 2009 Area Health Resource File (AHRF), which was linked to Medicaid administrative claims files using state and county codes where each beneficiary resided.
Study Population
The study population consisted of nonelderly (2164 years old) fee‐for‐service Medicaid‐only beneficiaries with selected chronic conditions and continuous enrollment during baseline and follow‐up period (Figure 1). Analyses were restricted to those who had at least 1 inpatient admission in 2007 and were conducted at the person‐level.

For the purpose of this study, Medicaid beneficiaries with 19 chronic conditions were selected: asthma, arthritis, cardiac arrhythmias, coronary artery disease, cancer, congestive heart failure, chronic kidney disease, chronic obstructive pulmonary disease, dementia, diabetes, hypertension, hyperlipidemia, hepatitis, human immunodeficiency virus osteoporosis, stroke, depression, schizophrenia, and substance use disorders. These conditions were identified based on the strategic framework developed and adopted by the Department of Health and Human Services for research, policy, program, and practice.[16]
Dependent Variable
Individuals were categorized into 2 groups, those with and without all‐cause 30‐day readmission. All‐cause 30‐day readmission was identified as subsequent hospitalization within 30 days of discharge date of the index hospitalization.
Key Independent Variables
These were index hospitalization characteristics, where LOS was the primary independent variable, reason for admission was the secondary independent variable, and month of index hospitalization (included to control for potential seasonal effect).
Other Independent Variables
Patient‐level characteristics included demographics (age, gender, and race/ethnicity) and Medicaid eligibility status (cash and medical need). Primary care access included continuity of care measured using a previously published continuity index (Modified Modified Continuity Index) and coordination of care, measured as primary care visit within 14 days of discharge date. Healthcare utilization was measured as an emergency room visit within 6 months prior to the index hospitalization.
Variables accounting for county socioeconomic status included educational attainment, per capita income, employment rate, poverty level, and metropolitan statistical area. Variables related to availability of providers and healthcare facilities were AHRF designations for primary/mental healthcare shortage areas, presence of federally qualified health centers, rural health centers, and community mental health centers. Hospital and primary care provider density was defined as total number of hospitals or primary care providers per 100,000 individuals, respectively.
Statistical Techniques
2 tests of independence were used for categorical variables and t tests for continuous variables to determine group differences in patient‐level and county‐level characteristics and all‐cause 30‐day readmission. Multilevel logistic regression models, which accounted for beneficiaries nested within counties, were used to examine the association between all‐cause 30‐day readmission and index hospitalization characteristics. The reference group for the dependent variable was no 30‐day readmission. Model 1 controlled for only patient‐level characteristics. Model 2 controlled for both patient‐level and county‐level characteristics. In both models, county was specified as a random intercept using the GLIMMIX procedure. All analyses were conducted using SAS version 9.3 (SAS Inc., Cary, NC).
RESULTS
After the exclusion criteria, there were 15,806 Medicaid beneficiaries with selected chronic conditions and at least 1 inpatient encounter in 2007. Overall, 16.7% experienced all‐cause 30‐day readmissions. A description of the study population and unadjusted associations between independent variables and all‐cause 30‐day readmission are presented in Table 1.
Variables | 30‐Day Readmission, 2,633 (16.7%) | No 30‐Day Readmission, 13,173 (83.3%) | Significance |
---|---|---|---|
| |||
Demographic and Medicaid eligibility characteristics | |||
Gender, N (%) | * | ||
Female | 1,715 (65.1%) | 9,274 (70.4%) | |
Male | 918 (34.9%) | 3,899 (29.6%) | |
Age group, N (%) | * | ||
2124 years | 301 (11.4%) | 1,675 (12.7%) | |
2534 years | 567 (21.5%) | 3,578 (27.2%) | |
3544 years | 517 (19.6%) | 2,498 (19.0%) | |
4554 years | 673 (25.6%) | 2,971 (22.6%) | |
5564 years | 575 (21.8%) | 2,451 (18.6%) | |
Race/ethnicity, N (%) | * | ||
Caucasian | 847 (32.2%) | 3,831 (29.1%) | |
African American | 988 (37.5%) | 4,270(32.4%) | |
Hispanic | 608 (23.1%) | 4,245 (32.2%) | |
Asian/AI/PI | 39 (1.5%) | 169 (1.3%) | |
Other | 151 (5.7%) | 658 (5.0%) | |
Cash eligibility, N (%) | 1,529 (58.1%) | 6,666 (50.6%) | * |
Medical need eligibility, N (%) | 876 (33.3%) | 3769 (28.6%) | * |
Index hospitalization characteristics | |||
Length of stay, mean [SD] | 6.62 [9.09] | 4.29 [6.35] | * |
Chronic conditions at admission, N (%) | |||
Arthritis/osteoporosis | 99 (3.8%) | 464 (3.5%) | |
Cancer | 134 (5.1%) | 429 (3.3%) | * |
Cardiovascular conditions | 995 (37.8%) | 3,733 (28.3%) | * |
COPD/asthma | 541 (20.5%) | 2,197 (16.7%) | * |
Diabetes | 575 (21.8%) | 2,103 (16.0%) | * |
HIV/hepatitis | 305 (11.6%) | 1,185 (9.0%) | * |
Mental health conditions | 1,491 (56.6%) | 4,352 (33.0%) | * |
Season of readmission, N (%) | * | ||
Spring | 730 (27.7%) | 3,944 (29.9%) | |
Summer | 401 (15.2%) | 2,332 (17.7%) | |
Fall | 211 (8.0%) | 1,605 (12.2%) | |
Winter | 1,291 (49.0%) | 5,292 (40.2%) | |
Primary care access, N (%) | |||
Coordination of primary care | 326 (12.4%) | 1,747 (13.3%) | |
Continuity of primary care, N (%) | |||
Complete care continuity | 349 (13.3%) | 1,764 (13.4%) | |
Some care continuity | 634 (24.1%) | 2,960 (22.5%) | |
No care continuity | 1650 (62.7%) | 8,449 (64.1%) | |
Healthcare utilization, N (%) | |||
Emergency room visit | 893 (33.9%) | 4,449 (33.8%) | |
County‐level characteristics | |||
Metropolitan status, N (%) | |||
Nonmetro | 267 (10.1%) | 1,285 (9.8%) | |
Metro | 2,366 (89.9%) | 11,888 (90.2%) | |
Primary care shortage area, N (%) | |||
Whole county | 2,034 (77.3%) | 10,147 (77.0%) | |
Part county | 429 (16.3%) | 2,312 (17.6%) | |
No shortage | 170 (6.5%) | 714 (5.4%) | |
Mental healthcare shortage area, N (%) | |||
Whole county | 2,015 (76.5%) | 9,925 (75.3%) | |
Part county | 388 (14.7%) | 2,242 (17.0%) | |
No shortage | 230 (8.7%) | 1,006 (7.6%) | |
CMHC, mean [SD] | 0.81 [1.23] | 0.94 [1.24] | * |
Rural health center, mean [SD] | 0.62 [3.03] | 1.06 [4.41] | * |
FQHC, mean [SD] | 37.69 [44.31] | 37.78 [42.98] | |
Education rate, 4+ years, mean [SD] | 25.39 [10.98] | 23.77 [10.51] | * |
Unemployment rate, mean [SD] | 4.57 [0.71] | 4.67 [0.90] | * |
% Below poverty level, mean [SD] | 15.11 [3.73] | 15.06 [3.80] | |
Per capita income (US dollars), mean [SD] | 58,761.96 [33,697.42] | 54,029.16 [31,265.86] | * |
Nonfederal PCP density, mean [SD] | 307.10 [192.29] | 279.97 [179.22] | * |
Hospital density, mean [SD] | 1.74 [1.37] | 1.65 [1.14] | * |
Multilevel logistic regressions of all‐cause 30‐day readmissions are summarized in Table 2. Beneficiaries with longer LOS had significantly higher odds of 30‐day readmission. In addition, presence of cancer, cardiovascular conditions, diabetes, and mental health conditions at index hospitalization significantly increased the odds of readmission. In addition, beneficiaries with cash or medical need eligibility had significantly higher odds of 30‐day readmission.
AOR | 95% CI | Significance | |
---|---|---|---|
| |||
Length of stay | 1.03 | [1.031.04] | * |
Chronic conditions at admission | |||
Arthritis/osteoporosis | 0.90 | [0.721.13] | |
Cancer | 1.55 | [1.261.90] | * |
Cardiovascular conditions | 1.20 | [1.081.33] | * |
COPD/asthma | 1.01 | [0.901.12] | |
Diabetes | 1.23 | [1.101.39] | * |
HIV/hepatitis | 0.98 | [0.851.12] | |
Mental health conditions | 2.17 | [1.982.38] | * |
Season of readmission | |||
Spring | 0.79 | [0.710.88] | * |
Summer | 0.77 | [0.680.88] | * |
Fall | 0.58 | [0.490.68] | * |
Winter | Reference | ||
Cash eligibility | 1.14 | [1.011.27] | |
Medical need eligibility | 1.21 | [1.081.36] |
DISCUSSION
To the best of our knowledge, this is the first study examining patient‐level and county‐level characteristics associated with all‐cause 30‐day readmission in Medicaid beneficiaries with chronic conditions. In addition, our findings add to the nascent literature on readmissions among Medicaid beneficiaries, with findings discussed below.
LOS has been reported as a risk factor for readmission both in elderly and nonelderly populations.[11] Our findings indicate that longer LOS is associated with increased odds of 30‐day readmission, which could be attributed to severity of illness at index hospitalization.[10] This finding could be related to unmeasured clinical severity (our models account for some comorbidities) and socioeconomic issues (as noted in the introduction). This may have implications for discharge planning efforts and focusing on chronic disease management, which has previously shown to be effective in reducing readmissions.[17] Our findings suggest 30‐day readmissions can be predicted using variables that are readily available, few in number, and simple to incorporate in discharge planning. Comprehensive discharge planning which takes into account chronic conditions and index hospitalization characteristics may help organize postdischarge services, including coordination of care with physicians, medication reconciliation, follow‐up care, and appropriate self‐management for chronic conditions.
Our findings of increased risk of 30‐day hospital readmissions as well as longer LOS among Medicaid beneficiaries with cancer, cardiovascular conditions, diabetes, and mental health conditions at index hospitalization suggests that patient complexity/poor health status increases the risk of readmission. A more focused approach in treatment of these diseases can help reduce readmissions. Integrated care management interventions after hospital discharge have been shown to reduce readmissions among those with heart disease; a coordinated care team including cardiologists, specialized nurses, and primary care physicians, and provision of integrated care following hospitalizations have shown benefit.[18, 19] Emerging models of delivery such as accountable care organizations and patient‐centered medical homes, which offer comprehensive, well‐coordinated primary care services, may be needed to reduce readmission among Medicaid beneficiaries with chronic health conditions. In this respect, 3 of the 4 states represented (California, New York, and Texas) are CMS Innovation Model partner states and are presently awardees of Medicaid Incentives for the Prevention of Chronic Disease state grants.[20] It remains to be seen whether such programs can reduce the high prevalence of readmissions in a Medicaid population.
Although our findings may have implications in reducing readmission risk, these results need to be interpreted in the light of study limitations. Our study was based on beneficiaries from only 4 states and cannot be generalized to the entire US Medicaid population. We also excluded individuals who were not enrolled in Medicaid health maintenance organizations. Given that less than one‐third of the population receives fee‐for‐service care in Medicaid, our study may have selection bias. Our study design utilized a retrospective cohort approach and cannot be used to establish causal relationships. Further, our study did not include adjustment for variables related to discharge planning or care coordination other than a primary care visit 14 days post discharge, which might influence the readmission risk of complex patients. Our study utilized data from administrative claims files.
Overall, our analyses revealed that patient complexities increased the risk of all‐cause 30‐day readmission for high‐risk Medicaid beneficiaries with chronic conditions, thus warranting the need for comprehensive care for those with chronic conditions. Programs designed to reduce the risk of 30‐day readmissions may need to focus on appropriate disease management and better coordinated care post hospitalization.
Disclosures
Research reported in this publication was supported by the Training Program in the Behavioral and Biomedical Sciences at West Virginia University, National Institute of General Medical Sciences grant number T32 GM08174, and the National Institute of General Medical Sciences of the National Institutes of Health under award number U54GM104942, and the Benedum Foundation. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analyses, decision to publish, or preparation of the manuscript.
Hospital readmissions that occur within 30 days of discharge are an important measure for assessing performance of the healthcare system and the quality of patient care.[1, 2] According to the Healthcare Cost and Utilization Project (HCUP), there were approximately 3.3 million adults with all‐cause 30‐day readmissions in the United States in 2011, incurring nearly $41.3 billion in hospital costs.[3] Reducing 30‐day readmissions has become a priority for payers, providers, and policymakers seeking to achieve improved quality of care at lower costs.
The implementation of the Affordable Care Act (ACA) provided the Centers for Medicare & Medicaid Services (CMS) statutory authority under the Hospital Readmissions Reduction Program to reduce payments for certain hospital readmissions that it deemed avoidable.[4] Although initial focus was on Medicare readmissions related to heart failure, myocardial infarction, and pneumonia, CMS is now considering expanding the list beyond the 3 conditions covered by the program.[4, 5] Therefore, it is important to understand major risk factors for readmissions in beneficiaries with chronic conditions.
Medicaid consists of the largest number of beneficiaries among all payers in the United States, with approximately 62 million beneficiaries in 2013.[5] The Medicaid population is further expected to increase with the coverage expansions under the ACA. In addition, the state Medicaid programs incur an estimated $374 billion in healthcare expenditures and provide healthcare services to the vulnerable, indigent, and disabled. It is estimated that 61% of adult Medicaid beneficiaries have chronic or disabling conditions that place them at an increased risk of hospitalization.[6] A series of HCUP statistical briefs reported several findings. First, Medicaid all‐cause readmission rates were comparable with Medicare but double the rate of private insurance.[7] Second, for readmissions following nonsurgical hospitalizations, 30‐day Medicaid readmission rates were higher than Medicare and private insurance for both acute and chronic conditions.[1] The effects of such costly utilization patterns, for this large and growing population necessitates heightened attention under healthcare reform.
The balance between hospital efficiency and quality of care is another crucial aspect for our healthcare system. However, length of stay (LOS), a proxy marker for efficiency, may conflict with hospital readmission rates, an indicator of quality. Further, CMS plans to bundle 30‐day readmission rates to reimbursement for the index hospitalization.[8]
The effect of LOS on readmission rates is complex, and previous studies have provided conflicting data regarding the relationship between LOS and subsequent readmission risk. Some indicate that shorter LOS is associated with a higher risk of readmission,[8, 9] whereas others suggest that extended LOS is associated with a higher risk of readmission.[10, 11, 12] However, most research on readmissions has focused on Medicare beneficiaries.[11, 13, 14] The readmission patterns of Medicaid beneficiaries differ from those of the geriatric Medicare beneficiaries, from a clinical and socioeconomic perspective. Considering the importance of 30‐day readmission for payers and policy makers, there is a need to understand the role of LOS and implications for treatment and management strategies.
Our study examined the association between index hospitalization characteristics (LOS and reason for admission) and all‐cause 30‐day readmission risk in fee‐for‐service high‐risk Medicaid beneficiaries. The study is limited to patients with selected chronic conditions and examines the differentiating factors within this high‐risk population. For the purpose of our study, variables were selected based on a priori knowledge and Andersen's behavioral model of health service utilization. This model suggests that potential health service use is determined by interactions among predisposing (demographics, index hospitalization characteristics), enabling (county level [eg, socioeconomic status]), and need (health status) characteristics of individuals and also the healthcare systems in the communities where they reside.[15]
METHODS
Study Design
A retrospective cohort approach was used with baseline and follow‐up periods. The baseline period was defined as the admission date of the index hospitalization (first observed hospitalization) between January 1, 2007 and December 31, 2007. Patients were followed for 180 days after discharge date of the associated index hospitalization.
Data Source
Medicaid administrative claims files from California, Illinois, New York, and Texas, between 2006 and 2008, were used. The personal summary file included information on demographics, Medicaid enrollment, and eligibility status. Outpatient and Inpatient files included claims for services provided in ambulatory and inpatient settings and contained International Classification of Diseases, 9th Revision, Clinical Modification codes. Information on county‐level characteristics were obtained from the 2009 Area Health Resource File (AHRF), which was linked to Medicaid administrative claims files using state and county codes where each beneficiary resided.
Study Population
The study population consisted of nonelderly (2164 years old) fee‐for‐service Medicaid‐only beneficiaries with selected chronic conditions and continuous enrollment during baseline and follow‐up period (Figure 1). Analyses were restricted to those who had at least 1 inpatient admission in 2007 and were conducted at the person‐level.

For the purpose of this study, Medicaid beneficiaries with 19 chronic conditions were selected: asthma, arthritis, cardiac arrhythmias, coronary artery disease, cancer, congestive heart failure, chronic kidney disease, chronic obstructive pulmonary disease, dementia, diabetes, hypertension, hyperlipidemia, hepatitis, human immunodeficiency virus osteoporosis, stroke, depression, schizophrenia, and substance use disorders. These conditions were identified based on the strategic framework developed and adopted by the Department of Health and Human Services for research, policy, program, and practice.[16]
Dependent Variable
Individuals were categorized into 2 groups, those with and without all‐cause 30‐day readmission. All‐cause 30‐day readmission was identified as subsequent hospitalization within 30 days of discharge date of the index hospitalization.
Key Independent Variables
These were index hospitalization characteristics, where LOS was the primary independent variable, reason for admission was the secondary independent variable, and month of index hospitalization (included to control for potential seasonal effect).
Other Independent Variables
Patient‐level characteristics included demographics (age, gender, and race/ethnicity) and Medicaid eligibility status (cash and medical need). Primary care access included continuity of care measured using a previously published continuity index (Modified Modified Continuity Index) and coordination of care, measured as primary care visit within 14 days of discharge date. Healthcare utilization was measured as an emergency room visit within 6 months prior to the index hospitalization.
Variables accounting for county socioeconomic status included educational attainment, per capita income, employment rate, poverty level, and metropolitan statistical area. Variables related to availability of providers and healthcare facilities were AHRF designations for primary/mental healthcare shortage areas, presence of federally qualified health centers, rural health centers, and community mental health centers. Hospital and primary care provider density was defined as total number of hospitals or primary care providers per 100,000 individuals, respectively.
Statistical Techniques
2 tests of independence were used for categorical variables and t tests for continuous variables to determine group differences in patient‐level and county‐level characteristics and all‐cause 30‐day readmission. Multilevel logistic regression models, which accounted for beneficiaries nested within counties, were used to examine the association between all‐cause 30‐day readmission and index hospitalization characteristics. The reference group for the dependent variable was no 30‐day readmission. Model 1 controlled for only patient‐level characteristics. Model 2 controlled for both patient‐level and county‐level characteristics. In both models, county was specified as a random intercept using the GLIMMIX procedure. All analyses were conducted using SAS version 9.3 (SAS Inc., Cary, NC).
RESULTS
After the exclusion criteria, there were 15,806 Medicaid beneficiaries with selected chronic conditions and at least 1 inpatient encounter in 2007. Overall, 16.7% experienced all‐cause 30‐day readmissions. A description of the study population and unadjusted associations between independent variables and all‐cause 30‐day readmission are presented in Table 1.
Variables | 30‐Day Readmission, 2,633 (16.7%) | No 30‐Day Readmission, 13,173 (83.3%) | Significance |
---|---|---|---|
| |||
Demographic and Medicaid eligibility characteristics | |||
Gender, N (%) | * | ||
Female | 1,715 (65.1%) | 9,274 (70.4%) | |
Male | 918 (34.9%) | 3,899 (29.6%) | |
Age group, N (%) | * | ||
2124 years | 301 (11.4%) | 1,675 (12.7%) | |
2534 years | 567 (21.5%) | 3,578 (27.2%) | |
3544 years | 517 (19.6%) | 2,498 (19.0%) | |
4554 years | 673 (25.6%) | 2,971 (22.6%) | |
5564 years | 575 (21.8%) | 2,451 (18.6%) | |
Race/ethnicity, N (%) | * | ||
Caucasian | 847 (32.2%) | 3,831 (29.1%) | |
African American | 988 (37.5%) | 4,270(32.4%) | |
Hispanic | 608 (23.1%) | 4,245 (32.2%) | |
Asian/AI/PI | 39 (1.5%) | 169 (1.3%) | |
Other | 151 (5.7%) | 658 (5.0%) | |
Cash eligibility, N (%) | 1,529 (58.1%) | 6,666 (50.6%) | * |
Medical need eligibility, N (%) | 876 (33.3%) | 3769 (28.6%) | * |
Index hospitalization characteristics | |||
Length of stay, mean [SD] | 6.62 [9.09] | 4.29 [6.35] | * |
Chronic conditions at admission, N (%) | |||
Arthritis/osteoporosis | 99 (3.8%) | 464 (3.5%) | |
Cancer | 134 (5.1%) | 429 (3.3%) | * |
Cardiovascular conditions | 995 (37.8%) | 3,733 (28.3%) | * |
COPD/asthma | 541 (20.5%) | 2,197 (16.7%) | * |
Diabetes | 575 (21.8%) | 2,103 (16.0%) | * |
HIV/hepatitis | 305 (11.6%) | 1,185 (9.0%) | * |
Mental health conditions | 1,491 (56.6%) | 4,352 (33.0%) | * |
Season of readmission, N (%) | * | ||
Spring | 730 (27.7%) | 3,944 (29.9%) | |
Summer | 401 (15.2%) | 2,332 (17.7%) | |
Fall | 211 (8.0%) | 1,605 (12.2%) | |
Winter | 1,291 (49.0%) | 5,292 (40.2%) | |
Primary care access, N (%) | |||
Coordination of primary care | 326 (12.4%) | 1,747 (13.3%) | |
Continuity of primary care, N (%) | |||
Complete care continuity | 349 (13.3%) | 1,764 (13.4%) | |
Some care continuity | 634 (24.1%) | 2,960 (22.5%) | |
No care continuity | 1650 (62.7%) | 8,449 (64.1%) | |
Healthcare utilization, N (%) | |||
Emergency room visit | 893 (33.9%) | 4,449 (33.8%) | |
County‐level characteristics | |||
Metropolitan status, N (%) | |||
Nonmetro | 267 (10.1%) | 1,285 (9.8%) | |
Metro | 2,366 (89.9%) | 11,888 (90.2%) | |
Primary care shortage area, N (%) | |||
Whole county | 2,034 (77.3%) | 10,147 (77.0%) | |
Part county | 429 (16.3%) | 2,312 (17.6%) | |
No shortage | 170 (6.5%) | 714 (5.4%) | |
Mental healthcare shortage area, N (%) | |||
Whole county | 2,015 (76.5%) | 9,925 (75.3%) | |
Part county | 388 (14.7%) | 2,242 (17.0%) | |
No shortage | 230 (8.7%) | 1,006 (7.6%) | |
CMHC, mean [SD] | 0.81 [1.23] | 0.94 [1.24] | * |
Rural health center, mean [SD] | 0.62 [3.03] | 1.06 [4.41] | * |
FQHC, mean [SD] | 37.69 [44.31] | 37.78 [42.98] | |
Education rate, 4+ years, mean [SD] | 25.39 [10.98] | 23.77 [10.51] | * |
Unemployment rate, mean [SD] | 4.57 [0.71] | 4.67 [0.90] | * |
% Below poverty level, mean [SD] | 15.11 [3.73] | 15.06 [3.80] | |
Per capita income (US dollars), mean [SD] | 58,761.96 [33,697.42] | 54,029.16 [31,265.86] | * |
Nonfederal PCP density, mean [SD] | 307.10 [192.29] | 279.97 [179.22] | * |
Hospital density, mean [SD] | 1.74 [1.37] | 1.65 [1.14] | * |
Multilevel logistic regressions of all‐cause 30‐day readmissions are summarized in Table 2. Beneficiaries with longer LOS had significantly higher odds of 30‐day readmission. In addition, presence of cancer, cardiovascular conditions, diabetes, and mental health conditions at index hospitalization significantly increased the odds of readmission. In addition, beneficiaries with cash or medical need eligibility had significantly higher odds of 30‐day readmission.
AOR | 95% CI | Significance | |
---|---|---|---|
| |||
Length of stay | 1.03 | [1.031.04] | * |
Chronic conditions at admission | |||
Arthritis/osteoporosis | 0.90 | [0.721.13] | |
Cancer | 1.55 | [1.261.90] | * |
Cardiovascular conditions | 1.20 | [1.081.33] | * |
COPD/asthma | 1.01 | [0.901.12] | |
Diabetes | 1.23 | [1.101.39] | * |
HIV/hepatitis | 0.98 | [0.851.12] | |
Mental health conditions | 2.17 | [1.982.38] | * |
Season of readmission | |||
Spring | 0.79 | [0.710.88] | * |
Summer | 0.77 | [0.680.88] | * |
Fall | 0.58 | [0.490.68] | * |
Winter | Reference | ||
Cash eligibility | 1.14 | [1.011.27] | |
Medical need eligibility | 1.21 | [1.081.36] |
DISCUSSION
To the best of our knowledge, this is the first study examining patient‐level and county‐level characteristics associated with all‐cause 30‐day readmission in Medicaid beneficiaries with chronic conditions. In addition, our findings add to the nascent literature on readmissions among Medicaid beneficiaries, with findings discussed below.
LOS has been reported as a risk factor for readmission both in elderly and nonelderly populations.[11] Our findings indicate that longer LOS is associated with increased odds of 30‐day readmission, which could be attributed to severity of illness at index hospitalization.[10] This finding could be related to unmeasured clinical severity (our models account for some comorbidities) and socioeconomic issues (as noted in the introduction). This may have implications for discharge planning efforts and focusing on chronic disease management, which has previously shown to be effective in reducing readmissions.[17] Our findings suggest 30‐day readmissions can be predicted using variables that are readily available, few in number, and simple to incorporate in discharge planning. Comprehensive discharge planning which takes into account chronic conditions and index hospitalization characteristics may help organize postdischarge services, including coordination of care with physicians, medication reconciliation, follow‐up care, and appropriate self‐management for chronic conditions.
Our findings of increased risk of 30‐day hospital readmissions as well as longer LOS among Medicaid beneficiaries with cancer, cardiovascular conditions, diabetes, and mental health conditions at index hospitalization suggests that patient complexity/poor health status increases the risk of readmission. A more focused approach in treatment of these diseases can help reduce readmissions. Integrated care management interventions after hospital discharge have been shown to reduce readmissions among those with heart disease; a coordinated care team including cardiologists, specialized nurses, and primary care physicians, and provision of integrated care following hospitalizations have shown benefit.[18, 19] Emerging models of delivery such as accountable care organizations and patient‐centered medical homes, which offer comprehensive, well‐coordinated primary care services, may be needed to reduce readmission among Medicaid beneficiaries with chronic health conditions. In this respect, 3 of the 4 states represented (California, New York, and Texas) are CMS Innovation Model partner states and are presently awardees of Medicaid Incentives for the Prevention of Chronic Disease state grants.[20] It remains to be seen whether such programs can reduce the high prevalence of readmissions in a Medicaid population.
Although our findings may have implications in reducing readmission risk, these results need to be interpreted in the light of study limitations. Our study was based on beneficiaries from only 4 states and cannot be generalized to the entire US Medicaid population. We also excluded individuals who were not enrolled in Medicaid health maintenance organizations. Given that less than one‐third of the population receives fee‐for‐service care in Medicaid, our study may have selection bias. Our study design utilized a retrospective cohort approach and cannot be used to establish causal relationships. Further, our study did not include adjustment for variables related to discharge planning or care coordination other than a primary care visit 14 days post discharge, which might influence the readmission risk of complex patients. Our study utilized data from administrative claims files.
Overall, our analyses revealed that patient complexities increased the risk of all‐cause 30‐day readmission for high‐risk Medicaid beneficiaries with chronic conditions, thus warranting the need for comprehensive care for those with chronic conditions. Programs designed to reduce the risk of 30‐day readmissions may need to focus on appropriate disease management and better coordinated care post hospitalization.
Disclosures
Research reported in this publication was supported by the Training Program in the Behavioral and Biomedical Sciences at West Virginia University, National Institute of General Medical Sciences grant number T32 GM08174, and the National Institute of General Medical Sciences of the National Institutes of Health under award number U54GM104942, and the Benedum Foundation. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analyses, decision to publish, or preparation of the manuscript.
Controlling Medicare Spending
Payers, providers, and policymakers are testing several major approaches to reducing US healthcare spending without harming quality. One strategy is to bundle payments for a longitudinal episode of care, as in Medicare's popular Bundled Payments for Care Improvement initiative.[1] A second approach is to decrease rates of inappropriate care, through programs such as Choosing Wisely, that discourage use of low‐value services.[2] Finally, a third approach adopted by the Medicare Shared Savings Program strives to reduce both episode costs and rates of inappropriate care, by incorporating annual per capita Medicare spending into performance benchmarks.[3] Given these ongoing efforts, it would be important to compare the potential impact of reducing episode payments versus rates of care on total costs of care.
METHODS
For 3 common surgical procedures, we compared the relative influence of procedure rates versus episode payments (among those with procedures) on total Medicare expenditures.
We used complete Part A and B Medicare claims data for: coronary artery bypass grafting (CABG), prostatectomy, and hip replacement. We used International Classification of Diseases, Ninth Revision codes to identify the procedures (CABG: 361.0, 361.1, 361.2, 361.3, 361.4, 361.5, 361.6, 361.7, 361.9, 36.2; prostatectomy: 60.4, 60.5, 60.62 with a prostate cancer diagnosis code of 185 or 233.4; and hip replacement: 81.51, 81.52 excluding hip fracture codes 820.0, 820.1, 820.2, 820.3, 820.8, 820.9).
For each procedure, we estimated age‐ and sex‐adjusted episode rates for each hospital referral region (HRR). The numerator was the number of admissions to an acute care hospital for CABG (total n = 118,185), prostatectomy (total n = 18,328), or hip replacement (total n = 178,982) from January 2009 to June 2010. The denominator was fee‐for‐service Medicare beneficiaries age 65 years or older. We excluded those without continuous Part A and B enrollment (total denominator n = 23,403,051). Females were also excluded from the prostatectomy cohort.
For each of the 306 HRRs, we next calculated average HRR‐level episode payments. Using CABG as an example, we aggregated up the risk‐adjusted (age, sex, race, admission type, Elixhauser[4] comorbidities), price‐standardized[5] episode payments for all CABG patients residing in an HRR, and divided this by the number of CABG patients living in that HRR.
Finally, we obtained baseline per capita spending by multiplying the age‐ and sex‐adjusted CABG episode rate by the average CABG episode payment in that HRR. All payments were standardized to 2010 dollars using the Consumer Price Index.
We simulated changes in per capita Medicare spending for CABG across all HRRs under 2 scenarios: (1) reducing HRR‐level rates to the median versus (2) reducing HRR‐level episode payments to the median. We repeated this for prostatectomy and hip replacement.
RESULTS
Age‐ and sex‐adjusted rates of CABG varied more than risk‐adjusted, price‐standardized episode payments (90th:10th percentile of 2.0 for rates vs 1.2 for payments) (see Supporting Information, Appendix, in the online version of this article). Reducing rates of CABG to the 50th percentile decreased per capita episode payments by 11.1%. In contrast, reducing CABG episode payments to the 50th percentile decreased per capita episode payments by 3.6%. The absolute difference between the 2 simulations was 7.5% (95% confidence interval [CI]: 5.6%‐9.4%) (Figure 1). Results were similar for prostatectomy and hip replacement. In sensitivity analyses, reducing hospital‐level episode payments (rather than HRR‐level episode payments) produced similar findings. Employing the 90th percentile as a cutoff (instead of the median) also produced qualitatively similar results.

For CABG, the absolute difference between the simulated decrease in per capita Medicare spending due to reducing rates versus reducing payments was 7.5% (95% confidence interval [CI]: 5.6%‐9.4%). For hip replacement, the absolute difference was 3.2% (95% CI: 1.9%‐4.4%). For prostatectomy, the absolute difference was 14.3% (95% CI: 11.0%‐17.6%). The effect of doing both is additive in this simulation, as we did not model possible complex interdependencies between reducing payments and rates. Abbreviations: CABG, coronary artery bypass grafting.
DISCUSSION
For 3 common surgical procedures, reducing procedure rates lowers total Medicare spending substantially more than reducing episode payments. These findings are attributable to a much greater variation in procedure rates compared to episode‐based payments. Prior research has documented wide variation in rates of surgical procedures.[6] This may be due to a number of factors, including physician beliefs about indications for surgery, as well as the degree to which patient preferences are incorporated into decision making.[6]
Our findings suggest that it would be important to incorporate population‐based episode rates into efforts aimed at incentivizing higher value care. Incentives tied to population‐based episode rates are difficult to design well. They may need to be paired with appropriateness criteria to avoid stinting on care. Attribution of a population to a hospital (including those who are not admitted to a hospital) is also complex.[7] Finally, hospitals are not solely responsible for rates of care, because the decision to admit a patient is sometimes made in the emergency department (eg, for chronic medical conditions), but at other times is made in the outpatient arena (eg, for elective surgery). Nevertheless, a narrow focus on per episode spending limits the potential impact of efforts to control Medicare spending.
Acknowledgements
The authors thank Mary Oerline, MS, Yubraj Acharya, MPA, and Haiyin Liu, MA, for the analytic support they provided. They were compensated for their work.
Disclosures: Dr. John Birkmeyer has equity interest in ArborMetrix, a company that profiles hospital quality and episode cost efficiency. The company played no role in the preparation of this article. This work was supported by funding from the National Institute of Aging (grant no. P01AG019783). Dr. Lena Chen is supported by a Career Development Grant Award (K08HS020671) from the Agency for Healthcare Research and Quality. The funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript.
- Centers for Medicare 370(7):589–592.
- Centers for Medicare 36(1):8–27.
- Prices don't drive regional Medicare spending variations. Health Aff (Millwood). 2010;29(3):537–543. , , , , , .
- Understanding of regional variation in the use of surgery. Lancet. 2013;382(9898):1121–1129. , , , , , .
- Assigning ambulatory patients and their physicians to hospitals: a method for obtaining population‐based provider performance measurements. Health Serv Res. 2007;42(1 pt 1):45–62. , , , .
Payers, providers, and policymakers are testing several major approaches to reducing US healthcare spending without harming quality. One strategy is to bundle payments for a longitudinal episode of care, as in Medicare's popular Bundled Payments for Care Improvement initiative.[1] A second approach is to decrease rates of inappropriate care, through programs such as Choosing Wisely, that discourage use of low‐value services.[2] Finally, a third approach adopted by the Medicare Shared Savings Program strives to reduce both episode costs and rates of inappropriate care, by incorporating annual per capita Medicare spending into performance benchmarks.[3] Given these ongoing efforts, it would be important to compare the potential impact of reducing episode payments versus rates of care on total costs of care.
METHODS
For 3 common surgical procedures, we compared the relative influence of procedure rates versus episode payments (among those with procedures) on total Medicare expenditures.
We used complete Part A and B Medicare claims data for: coronary artery bypass grafting (CABG), prostatectomy, and hip replacement. We used International Classification of Diseases, Ninth Revision codes to identify the procedures (CABG: 361.0, 361.1, 361.2, 361.3, 361.4, 361.5, 361.6, 361.7, 361.9, 36.2; prostatectomy: 60.4, 60.5, 60.62 with a prostate cancer diagnosis code of 185 or 233.4; and hip replacement: 81.51, 81.52 excluding hip fracture codes 820.0, 820.1, 820.2, 820.3, 820.8, 820.9).
For each procedure, we estimated age‐ and sex‐adjusted episode rates for each hospital referral region (HRR). The numerator was the number of admissions to an acute care hospital for CABG (total n = 118,185), prostatectomy (total n = 18,328), or hip replacement (total n = 178,982) from January 2009 to June 2010. The denominator was fee‐for‐service Medicare beneficiaries age 65 years or older. We excluded those without continuous Part A and B enrollment (total denominator n = 23,403,051). Females were also excluded from the prostatectomy cohort.
For each of the 306 HRRs, we next calculated average HRR‐level episode payments. Using CABG as an example, we aggregated up the risk‐adjusted (age, sex, race, admission type, Elixhauser[4] comorbidities), price‐standardized[5] episode payments for all CABG patients residing in an HRR, and divided this by the number of CABG patients living in that HRR.
Finally, we obtained baseline per capita spending by multiplying the age‐ and sex‐adjusted CABG episode rate by the average CABG episode payment in that HRR. All payments were standardized to 2010 dollars using the Consumer Price Index.
We simulated changes in per capita Medicare spending for CABG across all HRRs under 2 scenarios: (1) reducing HRR‐level rates to the median versus (2) reducing HRR‐level episode payments to the median. We repeated this for prostatectomy and hip replacement.
RESULTS
Age‐ and sex‐adjusted rates of CABG varied more than risk‐adjusted, price‐standardized episode payments (90th:10th percentile of 2.0 for rates vs 1.2 for payments) (see Supporting Information, Appendix, in the online version of this article). Reducing rates of CABG to the 50th percentile decreased per capita episode payments by 11.1%. In contrast, reducing CABG episode payments to the 50th percentile decreased per capita episode payments by 3.6%. The absolute difference between the 2 simulations was 7.5% (95% confidence interval [CI]: 5.6%‐9.4%) (Figure 1). Results were similar for prostatectomy and hip replacement. In sensitivity analyses, reducing hospital‐level episode payments (rather than HRR‐level episode payments) produced similar findings. Employing the 90th percentile as a cutoff (instead of the median) also produced qualitatively similar results.

For CABG, the absolute difference between the simulated decrease in per capita Medicare spending due to reducing rates versus reducing payments was 7.5% (95% confidence interval [CI]: 5.6%‐9.4%). For hip replacement, the absolute difference was 3.2% (95% CI: 1.9%‐4.4%). For prostatectomy, the absolute difference was 14.3% (95% CI: 11.0%‐17.6%). The effect of doing both is additive in this simulation, as we did not model possible complex interdependencies between reducing payments and rates. Abbreviations: CABG, coronary artery bypass grafting.
DISCUSSION
For 3 common surgical procedures, reducing procedure rates lowers total Medicare spending substantially more than reducing episode payments. These findings are attributable to a much greater variation in procedure rates compared to episode‐based payments. Prior research has documented wide variation in rates of surgical procedures.[6] This may be due to a number of factors, including physician beliefs about indications for surgery, as well as the degree to which patient preferences are incorporated into decision making.[6]
Our findings suggest that it would be important to incorporate population‐based episode rates into efforts aimed at incentivizing higher value care. Incentives tied to population‐based episode rates are difficult to design well. They may need to be paired with appropriateness criteria to avoid stinting on care. Attribution of a population to a hospital (including those who are not admitted to a hospital) is also complex.[7] Finally, hospitals are not solely responsible for rates of care, because the decision to admit a patient is sometimes made in the emergency department (eg, for chronic medical conditions), but at other times is made in the outpatient arena (eg, for elective surgery). Nevertheless, a narrow focus on per episode spending limits the potential impact of efforts to control Medicare spending.
Acknowledgements
The authors thank Mary Oerline, MS, Yubraj Acharya, MPA, and Haiyin Liu, MA, for the analytic support they provided. They were compensated for their work.
Disclosures: Dr. John Birkmeyer has equity interest in ArborMetrix, a company that profiles hospital quality and episode cost efficiency. The company played no role in the preparation of this article. This work was supported by funding from the National Institute of Aging (grant no. P01AG019783). Dr. Lena Chen is supported by a Career Development Grant Award (K08HS020671) from the Agency for Healthcare Research and Quality. The funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript.
Payers, providers, and policymakers are testing several major approaches to reducing US healthcare spending without harming quality. One strategy is to bundle payments for a longitudinal episode of care, as in Medicare's popular Bundled Payments for Care Improvement initiative.[1] A second approach is to decrease rates of inappropriate care, through programs such as Choosing Wisely, that discourage use of low‐value services.[2] Finally, a third approach adopted by the Medicare Shared Savings Program strives to reduce both episode costs and rates of inappropriate care, by incorporating annual per capita Medicare spending into performance benchmarks.[3] Given these ongoing efforts, it would be important to compare the potential impact of reducing episode payments versus rates of care on total costs of care.
METHODS
For 3 common surgical procedures, we compared the relative influence of procedure rates versus episode payments (among those with procedures) on total Medicare expenditures.
We used complete Part A and B Medicare claims data for: coronary artery bypass grafting (CABG), prostatectomy, and hip replacement. We used International Classification of Diseases, Ninth Revision codes to identify the procedures (CABG: 361.0, 361.1, 361.2, 361.3, 361.4, 361.5, 361.6, 361.7, 361.9, 36.2; prostatectomy: 60.4, 60.5, 60.62 with a prostate cancer diagnosis code of 185 or 233.4; and hip replacement: 81.51, 81.52 excluding hip fracture codes 820.0, 820.1, 820.2, 820.3, 820.8, 820.9).
For each procedure, we estimated age‐ and sex‐adjusted episode rates for each hospital referral region (HRR). The numerator was the number of admissions to an acute care hospital for CABG (total n = 118,185), prostatectomy (total n = 18,328), or hip replacement (total n = 178,982) from January 2009 to June 2010. The denominator was fee‐for‐service Medicare beneficiaries age 65 years or older. We excluded those without continuous Part A and B enrollment (total denominator n = 23,403,051). Females were also excluded from the prostatectomy cohort.
For each of the 306 HRRs, we next calculated average HRR‐level episode payments. Using CABG as an example, we aggregated up the risk‐adjusted (age, sex, race, admission type, Elixhauser[4] comorbidities), price‐standardized[5] episode payments for all CABG patients residing in an HRR, and divided this by the number of CABG patients living in that HRR.
Finally, we obtained baseline per capita spending by multiplying the age‐ and sex‐adjusted CABG episode rate by the average CABG episode payment in that HRR. All payments were standardized to 2010 dollars using the Consumer Price Index.
We simulated changes in per capita Medicare spending for CABG across all HRRs under 2 scenarios: (1) reducing HRR‐level rates to the median versus (2) reducing HRR‐level episode payments to the median. We repeated this for prostatectomy and hip replacement.
RESULTS
Age‐ and sex‐adjusted rates of CABG varied more than risk‐adjusted, price‐standardized episode payments (90th:10th percentile of 2.0 for rates vs 1.2 for payments) (see Supporting Information, Appendix, in the online version of this article). Reducing rates of CABG to the 50th percentile decreased per capita episode payments by 11.1%. In contrast, reducing CABG episode payments to the 50th percentile decreased per capita episode payments by 3.6%. The absolute difference between the 2 simulations was 7.5% (95% confidence interval [CI]: 5.6%‐9.4%) (Figure 1). Results were similar for prostatectomy and hip replacement. In sensitivity analyses, reducing hospital‐level episode payments (rather than HRR‐level episode payments) produced similar findings. Employing the 90th percentile as a cutoff (instead of the median) also produced qualitatively similar results.

For CABG, the absolute difference between the simulated decrease in per capita Medicare spending due to reducing rates versus reducing payments was 7.5% (95% confidence interval [CI]: 5.6%‐9.4%). For hip replacement, the absolute difference was 3.2% (95% CI: 1.9%‐4.4%). For prostatectomy, the absolute difference was 14.3% (95% CI: 11.0%‐17.6%). The effect of doing both is additive in this simulation, as we did not model possible complex interdependencies between reducing payments and rates. Abbreviations: CABG, coronary artery bypass grafting.
DISCUSSION
For 3 common surgical procedures, reducing procedure rates lowers total Medicare spending substantially more than reducing episode payments. These findings are attributable to a much greater variation in procedure rates compared to episode‐based payments. Prior research has documented wide variation in rates of surgical procedures.[6] This may be due to a number of factors, including physician beliefs about indications for surgery, as well as the degree to which patient preferences are incorporated into decision making.[6]
Our findings suggest that it would be important to incorporate population‐based episode rates into efforts aimed at incentivizing higher value care. Incentives tied to population‐based episode rates are difficult to design well. They may need to be paired with appropriateness criteria to avoid stinting on care. Attribution of a population to a hospital (including those who are not admitted to a hospital) is also complex.[7] Finally, hospitals are not solely responsible for rates of care, because the decision to admit a patient is sometimes made in the emergency department (eg, for chronic medical conditions), but at other times is made in the outpatient arena (eg, for elective surgery). Nevertheless, a narrow focus on per episode spending limits the potential impact of efforts to control Medicare spending.
Acknowledgements
The authors thank Mary Oerline, MS, Yubraj Acharya, MPA, and Haiyin Liu, MA, for the analytic support they provided. They were compensated for their work.
Disclosures: Dr. John Birkmeyer has equity interest in ArborMetrix, a company that profiles hospital quality and episode cost efficiency. The company played no role in the preparation of this article. This work was supported by funding from the National Institute of Aging (grant no. P01AG019783). Dr. Lena Chen is supported by a Career Development Grant Award (K08HS020671) from the Agency for Healthcare Research and Quality. The funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript.
- Centers for Medicare 370(7):589–592.
- Centers for Medicare 36(1):8–27.
- Prices don't drive regional Medicare spending variations. Health Aff (Millwood). 2010;29(3):537–543. , , , , , .
- Understanding of regional variation in the use of surgery. Lancet. 2013;382(9898):1121–1129. , , , , , .
- Assigning ambulatory patients and their physicians to hospitals: a method for obtaining population‐based provider performance measurements. Health Serv Res. 2007;42(1 pt 1):45–62. , , , .
- Centers for Medicare 370(7):589–592.
- Centers for Medicare 36(1):8–27.
- Prices don't drive regional Medicare spending variations. Health Aff (Millwood). 2010;29(3):537–543. , , , , , .
- Understanding of regional variation in the use of surgery. Lancet. 2013;382(9898):1121–1129. , , , , , .
- Assigning ambulatory patients and their physicians to hospitals: a method for obtaining population‐based provider performance measurements. Health Serv Res. 2007;42(1 pt 1):45–62. , , , .
Entering an era of intelligent combination therapy in cancer
The past few decades have witnessed unprecedented advances in our understanding of the molecular underpinnings of cancer. Although indiscriminately cytotoxic therapies like chemo- and radiation therapy remain standard of care for many cancer types, more precise targeted therapies and immune-boosting immunotherapies have added to our arsenal and afforded considerable survival gains. Despite those advances, we are still no closer to a cure, particularly for the most aggressive and insidious cancers that progress rapidly or go undiagnosed until advanced stages of disease. The substantial genetic diversity of tumors and universal nature of drug resistance present the most formidable and enduring challenges to effective cancer treatment.
Click on the PDF icon at the top of this introduction to read the full article.
The past few decades have witnessed unprecedented advances in our understanding of the molecular underpinnings of cancer. Although indiscriminately cytotoxic therapies like chemo- and radiation therapy remain standard of care for many cancer types, more precise targeted therapies and immune-boosting immunotherapies have added to our arsenal and afforded considerable survival gains. Despite those advances, we are still no closer to a cure, particularly for the most aggressive and insidious cancers that progress rapidly or go undiagnosed until advanced stages of disease. The substantial genetic diversity of tumors and universal nature of drug resistance present the most formidable and enduring challenges to effective cancer treatment.
Click on the PDF icon at the top of this introduction to read the full article.
The past few decades have witnessed unprecedented advances in our understanding of the molecular underpinnings of cancer. Although indiscriminately cytotoxic therapies like chemo- and radiation therapy remain standard of care for many cancer types, more precise targeted therapies and immune-boosting immunotherapies have added to our arsenal and afforded considerable survival gains. Despite those advances, we are still no closer to a cure, particularly for the most aggressive and insidious cancers that progress rapidly or go undiagnosed until advanced stages of disease. The substantial genetic diversity of tumors and universal nature of drug resistance present the most formidable and enduring challenges to effective cancer treatment.
Click on the PDF icon at the top of this introduction to read the full article.
Sexual health assessment and counseling: oncology nurses’ perceptions, practices, and perceived barriers
Click on the PDF icon at the top of this introduction to read the full article.
Click on the PDF icon at the top of this introduction to read the full article.
Click on the PDF icon at the top of this introduction to read the full article.
Racial disparities in breast cancer diagnosis in Central Georgia in the United States
Objective To investigate the presence of racial disparities in clinical staging in women diagnosed with breast cancer and understand whether such disparities exist in Central Georgia in the United States.
Methods We retrospectively reviewed records from the Tumor Registry of the Medical Center Navicent Health in Macon, Georgia, of women who had been diagnosed with breast cancer during 2011-2013. The chi-square test was used to assess statistically significant differences between whites and African Americans. We also assessed the patients’ health insurance status and age at diagnosis.
Results A total of 578 participants were identified. Statistically significant differences existed in the clinical stage between the races (P = .0003). Whites were more often clinical stage I at diagnosis, whereas African Americans had a greater percentage of stages II, III, or IV. African Americans were more than twice as likely to be diagnosed at clinical stage IV than were their white counterparts. Statistical differences also existed with age at diagnosis (P = .0066) and insurance coverage (P = .0004). A greater percentage of white patients were aged 65 years or older at diagnosis, whereas a greater percentage of African American patients were aged 49 years or younger. A greater percentage of African Americans had Medicaid insurance, whereas a greater percentage of whites had private health insurance.
Limitations As a single-center study, it is difficult to generalize these results elsewhere. Furthermore, this study focused on association and not on causation. It is difficult to pinpoint why such disparities exist.
Conclusion The etiology of racial disparities between African American and white women with breast cancer seems to be multifaceted. Screening mammography remains an important tool for identifying breast cancer. Low socioeconomic and educational status as well as a lack of a primary care physician may play a role in these disparities. Other factors that may have a role include biological factors and possible mistrust of the health care system.
Click on the PDF icon at the top of this introduction to read the full article.
Objective To investigate the presence of racial disparities in clinical staging in women diagnosed with breast cancer and understand whether such disparities exist in Central Georgia in the United States.
Methods We retrospectively reviewed records from the Tumor Registry of the Medical Center Navicent Health in Macon, Georgia, of women who had been diagnosed with breast cancer during 2011-2013. The chi-square test was used to assess statistically significant differences between whites and African Americans. We also assessed the patients’ health insurance status and age at diagnosis.
Results A total of 578 participants were identified. Statistically significant differences existed in the clinical stage between the races (P = .0003). Whites were more often clinical stage I at diagnosis, whereas African Americans had a greater percentage of stages II, III, or IV. African Americans were more than twice as likely to be diagnosed at clinical stage IV than were their white counterparts. Statistical differences also existed with age at diagnosis (P = .0066) and insurance coverage (P = .0004). A greater percentage of white patients were aged 65 years or older at diagnosis, whereas a greater percentage of African American patients were aged 49 years or younger. A greater percentage of African Americans had Medicaid insurance, whereas a greater percentage of whites had private health insurance.
Limitations As a single-center study, it is difficult to generalize these results elsewhere. Furthermore, this study focused on association and not on causation. It is difficult to pinpoint why such disparities exist.
Conclusion The etiology of racial disparities between African American and white women with breast cancer seems to be multifaceted. Screening mammography remains an important tool for identifying breast cancer. Low socioeconomic and educational status as well as a lack of a primary care physician may play a role in these disparities. Other factors that may have a role include biological factors and possible mistrust of the health care system.
Click on the PDF icon at the top of this introduction to read the full article.
Objective To investigate the presence of racial disparities in clinical staging in women diagnosed with breast cancer and understand whether such disparities exist in Central Georgia in the United States.
Methods We retrospectively reviewed records from the Tumor Registry of the Medical Center Navicent Health in Macon, Georgia, of women who had been diagnosed with breast cancer during 2011-2013. The chi-square test was used to assess statistically significant differences between whites and African Americans. We also assessed the patients’ health insurance status and age at diagnosis.
Results A total of 578 participants were identified. Statistically significant differences existed in the clinical stage between the races (P = .0003). Whites were more often clinical stage I at diagnosis, whereas African Americans had a greater percentage of stages II, III, or IV. African Americans were more than twice as likely to be diagnosed at clinical stage IV than were their white counterparts. Statistical differences also existed with age at diagnosis (P = .0066) and insurance coverage (P = .0004). A greater percentage of white patients were aged 65 years or older at diagnosis, whereas a greater percentage of African American patients were aged 49 years or younger. A greater percentage of African Americans had Medicaid insurance, whereas a greater percentage of whites had private health insurance.
Limitations As a single-center study, it is difficult to generalize these results elsewhere. Furthermore, this study focused on association and not on causation. It is difficult to pinpoint why such disparities exist.
Conclusion The etiology of racial disparities between African American and white women with breast cancer seems to be multifaceted. Screening mammography remains an important tool for identifying breast cancer. Low socioeconomic and educational status as well as a lack of a primary care physician may play a role in these disparities. Other factors that may have a role include biological factors and possible mistrust of the health care system.
Click on the PDF icon at the top of this introduction to read the full article.
Cancer clinical trial enrollment of diverse and underserved patients within an urban safety net hospital
Background Enrollment rates onto cancer clinical trials are low and reflect a small subset of the population of which even fewer participants come from populations of racial or ethnic diversity or low socioeconomic status. There is a need to increase enrollment onto cancer clinical trials with a focus on recruitment of a diverse, underrepresented patient population.
Objective To use the electronic medical record (EMR) to understand the eligibility and enrollment rates for all available cancer trials in the ambulatory care setting at an urban safety net hospital to identify specific strategies for enhanced accrual onto cancer clinical trials of diverse and underserved patients.
Methods A clinical trial screening note was created for the EMR by the clinical trials office at an urban safety net hospital. 847 cancer clinical trial screening notes were extracted from the EMR between January 1, 2010 and December 31, 2010. During that time, 99 cancer trials were registered for accrual, including clinical treatment, survey, data repository, imaging, and symptom management trials. Data on eligibility, enrollment status, and relationship to sociodemographic status were compared.
Limitations This is a single-institution and retrospective study.
Conclusion The findings demonstrate that a formal process of tracking cancer clinical trial screens using an EMR can document baseline rates of institution-specific accrual patterns and identify targeted strategies for increasing cancer clinical trial enrollment among a vulnerable patient population. Offering nontreatment trials may be an important and strategic method of engaging this vulnerable population in clinical research.
Funding/sponsorship Boston Medical Center Minority-Based Community Clinical Oncology Program (NCI 1U-10CA129519- 01A1), Boston Me
Click on the PDF icon at the top of this introduction to read the full article.
Background Enrollment rates onto cancer clinical trials are low and reflect a small subset of the population of which even fewer participants come from populations of racial or ethnic diversity or low socioeconomic status. There is a need to increase enrollment onto cancer clinical trials with a focus on recruitment of a diverse, underrepresented patient population.
Objective To use the electronic medical record (EMR) to understand the eligibility and enrollment rates for all available cancer trials in the ambulatory care setting at an urban safety net hospital to identify specific strategies for enhanced accrual onto cancer clinical trials of diverse and underserved patients.
Methods A clinical trial screening note was created for the EMR by the clinical trials office at an urban safety net hospital. 847 cancer clinical trial screening notes were extracted from the EMR between January 1, 2010 and December 31, 2010. During that time, 99 cancer trials were registered for accrual, including clinical treatment, survey, data repository, imaging, and symptom management trials. Data on eligibility, enrollment status, and relationship to sociodemographic status were compared.
Limitations This is a single-institution and retrospective study.
Conclusion The findings demonstrate that a formal process of tracking cancer clinical trial screens using an EMR can document baseline rates of institution-specific accrual patterns and identify targeted strategies for increasing cancer clinical trial enrollment among a vulnerable patient population. Offering nontreatment trials may be an important and strategic method of engaging this vulnerable population in clinical research.
Funding/sponsorship Boston Medical Center Minority-Based Community Clinical Oncology Program (NCI 1U-10CA129519- 01A1), Boston Me
Click on the PDF icon at the top of this introduction to read the full article.
Background Enrollment rates onto cancer clinical trials are low and reflect a small subset of the population of which even fewer participants come from populations of racial or ethnic diversity or low socioeconomic status. There is a need to increase enrollment onto cancer clinical trials with a focus on recruitment of a diverse, underrepresented patient population.
Objective To use the electronic medical record (EMR) to understand the eligibility and enrollment rates for all available cancer trials in the ambulatory care setting at an urban safety net hospital to identify specific strategies for enhanced accrual onto cancer clinical trials of diverse and underserved patients.
Methods A clinical trial screening note was created for the EMR by the clinical trials office at an urban safety net hospital. 847 cancer clinical trial screening notes were extracted from the EMR between January 1, 2010 and December 31, 2010. During that time, 99 cancer trials were registered for accrual, including clinical treatment, survey, data repository, imaging, and symptom management trials. Data on eligibility, enrollment status, and relationship to sociodemographic status were compared.
Limitations This is a single-institution and retrospective study.
Conclusion The findings demonstrate that a formal process of tracking cancer clinical trial screens using an EMR can document baseline rates of institution-specific accrual patterns and identify targeted strategies for increasing cancer clinical trial enrollment among a vulnerable patient population. Offering nontreatment trials may be an important and strategic method of engaging this vulnerable population in clinical research.
Funding/sponsorship Boston Medical Center Minority-Based Community Clinical Oncology Program (NCI 1U-10CA129519- 01A1), Boston Me
Click on the PDF icon at the top of this introduction to read the full article.
Implementation of distress screening in an oncology setting
The recommendations of numerous groups, such as the Institute of Medicine and the National Comprehensive Cancer Network, have resulted in the first regulatory standard on distress screening in oncology implemented in 2015 by the American College of Surgeons Commission on Cancer. This practice-changing standard promises to result in better quality cancer care, but presents unique challenges to many centers struggling to provide high-quality practical assessment and management of distress. The current paper reviews the history behind the CoC standard, identifies the most prevalent symptoms underlying distress, and discusses the importance of distress screening. We also review some commonly used instruments for assessing distress, and address barriers to implementation of screening and management.
Click on the PDF icon at the top of this introduction to read the full article.
The recommendations of numerous groups, such as the Institute of Medicine and the National Comprehensive Cancer Network, have resulted in the first regulatory standard on distress screening in oncology implemented in 2015 by the American College of Surgeons Commission on Cancer. This practice-changing standard promises to result in better quality cancer care, but presents unique challenges to many centers struggling to provide high-quality practical assessment and management of distress. The current paper reviews the history behind the CoC standard, identifies the most prevalent symptoms underlying distress, and discusses the importance of distress screening. We also review some commonly used instruments for assessing distress, and address barriers to implementation of screening and management.
Click on the PDF icon at the top of this introduction to read the full article.
The recommendations of numerous groups, such as the Institute of Medicine and the National Comprehensive Cancer Network, have resulted in the first regulatory standard on distress screening in oncology implemented in 2015 by the American College of Surgeons Commission on Cancer. This practice-changing standard promises to result in better quality cancer care, but presents unique challenges to many centers struggling to provide high-quality practical assessment and management of distress. The current paper reviews the history behind the CoC standard, identifies the most prevalent symptoms underlying distress, and discusses the importance of distress screening. We also review some commonly used instruments for assessing distress, and address barriers to implementation of screening and management.
Click on the PDF icon at the top of this introduction to read the full article.
Benchmarks are coming
We have actively avoided benchmarks in medicine since time immemorial. There is a strong argument that rote, one-size-fits-all parameters for care medicine are bad for our patients, and obviously they interfere with our flexibility in dealing with complex obscure diseases. This flexibility is critical in dermatology, where we deal with over 3,000 diseases, and there truly is more art than science involved in treating some of them.
Nonetheless, here come the benchmarks. Since we have not provided them, they have been provided for us. Look no further than United Health Care’s Optum program, or Cigna’s star ratings, both of which rank on average costs, without regard to subspecialty or intensity of disease.
Benchmarks have proven useful in industry and have improved quality there. I expect they will be most annoying to practicing physicians. There are also great variations in practice patterns we must make sure are accounted for. A pediatric dermatologist, for example, does radically fewer skin biopsies than a Mohs surgeon, and diagnoses many fewer malignancies. However, some things are inexplicable, even after opening two standard deviations, and you need to be aware they may be coming.
The Medicare data release was an eye opener for many. This information is readily available on multiple web sites in numeric and graphic display. You should look yourself and your “peers” up on the Wall Street Journal or ProPublicaweb sites. For example, it is hard to fathom how every closure can be a flap, or how every Mohs case is four stages. Or even more bizarre, how you can do Mohs and never have a second stage. It is hard to understand how most dermatologists have a certain number of skin biopsies or shave excisions per patient encounter and others ten times as many. With this in mind, I encourage all of you to look at your own ratios of procedures compared to your peers. Recall that Medicare data lag two years before publication. Areas that could be under scrutiny include:
• Number of skin biopsies per encounter.
• Number of repeat patient encounters per year.
• Number of lesion destructions per patient.
• Ratio of first to additional layers of Mohs.
• Number of Mohs procedures on trunk and extremities, compared with head and neck.
• Percentage of closures done with adjacent tissue transfers.
• Number of shave excisions per patient.
• Number of complex closures, compared with layered closures, particularly on the trunk and extremities.
• Number of diagnostic frozen sections.
• Frequency of use of special stains on pathology specimens.
We need to be actively involved in the development of these so that we are not forced into a one size fits all mold. I expect this will start with the private insurers, including Medicare advantage plans, since they have real time data analysis, and a keen desire to save money. These “benchmarks” will be a work in progress and will infuriate some of you. They are, however, more credible, and better, than the current state of affairs, where insurance companies rank you by simply averaging your costs under your tax identification number.
So heads up, benchmarks are coming your way. Review your own public data, compared with your peers and see if you are an outlier, and if so, ponder the reason why. It is not too late to take corrective action.
Dr. Coldiron is a past president of the American Academy of Dermatology. He is currently in private practice, but maintains a clinical assistant professorship at the University of Cincinnati. He cares for patients, teaches medical students and residents, and has several active clinical research projects. Dr. Coldiron is the author of more than 80 scientific letters, papers, and several book chapters, and he speaks frequently on a variety of topics. Reach him at [email protected].
We have actively avoided benchmarks in medicine since time immemorial. There is a strong argument that rote, one-size-fits-all parameters for care medicine are bad for our patients, and obviously they interfere with our flexibility in dealing with complex obscure diseases. This flexibility is critical in dermatology, where we deal with over 3,000 diseases, and there truly is more art than science involved in treating some of them.
Nonetheless, here come the benchmarks. Since we have not provided them, they have been provided for us. Look no further than United Health Care’s Optum program, or Cigna’s star ratings, both of which rank on average costs, without regard to subspecialty or intensity of disease.
Benchmarks have proven useful in industry and have improved quality there. I expect they will be most annoying to practicing physicians. There are also great variations in practice patterns we must make sure are accounted for. A pediatric dermatologist, for example, does radically fewer skin biopsies than a Mohs surgeon, and diagnoses many fewer malignancies. However, some things are inexplicable, even after opening two standard deviations, and you need to be aware they may be coming.
The Medicare data release was an eye opener for many. This information is readily available on multiple web sites in numeric and graphic display. You should look yourself and your “peers” up on the Wall Street Journal or ProPublicaweb sites. For example, it is hard to fathom how every closure can be a flap, or how every Mohs case is four stages. Or even more bizarre, how you can do Mohs and never have a second stage. It is hard to understand how most dermatologists have a certain number of skin biopsies or shave excisions per patient encounter and others ten times as many. With this in mind, I encourage all of you to look at your own ratios of procedures compared to your peers. Recall that Medicare data lag two years before publication. Areas that could be under scrutiny include:
• Number of skin biopsies per encounter.
• Number of repeat patient encounters per year.
• Number of lesion destructions per patient.
• Ratio of first to additional layers of Mohs.
• Number of Mohs procedures on trunk and extremities, compared with head and neck.
• Percentage of closures done with adjacent tissue transfers.
• Number of shave excisions per patient.
• Number of complex closures, compared with layered closures, particularly on the trunk and extremities.
• Number of diagnostic frozen sections.
• Frequency of use of special stains on pathology specimens.
We need to be actively involved in the development of these so that we are not forced into a one size fits all mold. I expect this will start with the private insurers, including Medicare advantage plans, since they have real time data analysis, and a keen desire to save money. These “benchmarks” will be a work in progress and will infuriate some of you. They are, however, more credible, and better, than the current state of affairs, where insurance companies rank you by simply averaging your costs under your tax identification number.
So heads up, benchmarks are coming your way. Review your own public data, compared with your peers and see if you are an outlier, and if so, ponder the reason why. It is not too late to take corrective action.
Dr. Coldiron is a past president of the American Academy of Dermatology. He is currently in private practice, but maintains a clinical assistant professorship at the University of Cincinnati. He cares for patients, teaches medical students and residents, and has several active clinical research projects. Dr. Coldiron is the author of more than 80 scientific letters, papers, and several book chapters, and he speaks frequently on a variety of topics. Reach him at [email protected].
We have actively avoided benchmarks in medicine since time immemorial. There is a strong argument that rote, one-size-fits-all parameters for care medicine are bad for our patients, and obviously they interfere with our flexibility in dealing with complex obscure diseases. This flexibility is critical in dermatology, where we deal with over 3,000 diseases, and there truly is more art than science involved in treating some of them.
Nonetheless, here come the benchmarks. Since we have not provided them, they have been provided for us. Look no further than United Health Care’s Optum program, or Cigna’s star ratings, both of which rank on average costs, without regard to subspecialty or intensity of disease.
Benchmarks have proven useful in industry and have improved quality there. I expect they will be most annoying to practicing physicians. There are also great variations in practice patterns we must make sure are accounted for. A pediatric dermatologist, for example, does radically fewer skin biopsies than a Mohs surgeon, and diagnoses many fewer malignancies. However, some things are inexplicable, even after opening two standard deviations, and you need to be aware they may be coming.
The Medicare data release was an eye opener for many. This information is readily available on multiple web sites in numeric and graphic display. You should look yourself and your “peers” up on the Wall Street Journal or ProPublicaweb sites. For example, it is hard to fathom how every closure can be a flap, or how every Mohs case is four stages. Or even more bizarre, how you can do Mohs and never have a second stage. It is hard to understand how most dermatologists have a certain number of skin biopsies or shave excisions per patient encounter and others ten times as many. With this in mind, I encourage all of you to look at your own ratios of procedures compared to your peers. Recall that Medicare data lag two years before publication. Areas that could be under scrutiny include:
• Number of skin biopsies per encounter.
• Number of repeat patient encounters per year.
• Number of lesion destructions per patient.
• Ratio of first to additional layers of Mohs.
• Number of Mohs procedures on trunk and extremities, compared with head and neck.
• Percentage of closures done with adjacent tissue transfers.
• Number of shave excisions per patient.
• Number of complex closures, compared with layered closures, particularly on the trunk and extremities.
• Number of diagnostic frozen sections.
• Frequency of use of special stains on pathology specimens.
We need to be actively involved in the development of these so that we are not forced into a one size fits all mold. I expect this will start with the private insurers, including Medicare advantage plans, since they have real time data analysis, and a keen desire to save money. These “benchmarks” will be a work in progress and will infuriate some of you. They are, however, more credible, and better, than the current state of affairs, where insurance companies rank you by simply averaging your costs under your tax identification number.
So heads up, benchmarks are coming your way. Review your own public data, compared with your peers and see if you are an outlier, and if so, ponder the reason why. It is not too late to take corrective action.
Dr. Coldiron is a past president of the American Academy of Dermatology. He is currently in private practice, but maintains a clinical assistant professorship at the University of Cincinnati. He cares for patients, teaches medical students and residents, and has several active clinical research projects. Dr. Coldiron is the author of more than 80 scientific letters, papers, and several book chapters, and he speaks frequently on a variety of topics. Reach him at [email protected].