Risk of anaphylaxis with IV iron products

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Iron dextran drip

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Researchers have compared the risk of anaphylaxis with different intravenous (IV) iron products and found evidence to suggest that iron dextran poses the greatest risk.

Compared with nondextran formulations, iron dextran was associated with a higher cumulative risk of anaphylaxis and an increased risk of anaphylaxis at first administration.

Iron sucrose was associated with the lowest risk of anaphylaxis, both cumulative and at first administration.

Cunlin Wang, MD, PhD, of the US Food and Drug Administration in Silver Spring, Maryland, and his colleagues conducted this research and reported the results in JAMA.

The researchers studied 688,183 recipients of IV iron enrolled in the fee-for-service Medicare program from January 2003 to December 2013.

The team examined administrations of IV iron dextran, gluconate, sucrose, or ferumoxytol. They identified 247,500 iron dextran and 440,683 nondextran users during the study period.

Overall, there were 274 cases of anaphylaxis at first exposure to IV iron and an additional 170 cases during subsequent iron administrations.

At first administration, iron dextran was associated with a higher anaphylaxis risk than nondextran formulations.  The risk of anaphylaxis was 68 per 100,000 persons for iron dextran and 24 per 100,000 persons for all nondextran products combined. The odds ratio—adjusted for age, indication, history of coronary heart disease, and hypertension—was 2.6 (P<0.001).

Among the nondextran products, the risk of anaphylaxis at first administration was higher with both iron gluconate and ferumoxytol than with iron sucrose. When compared with iron sucrose, the adjusted odds ratio of anaphylaxis was 3.6 for iron dextran, 2.0 for iron gluconate, and 2.2 for ferumoxytol.

Because each IV iron product has a specific recommended dose and schedule of administration, the researchers also calculated the cumulative risk of anaphylaxis based on both the number of administrations and the clinically relevant repletion level of iron (1000 mg) achieved within 12 weeks.

The cumulative risk of anaphylaxis over multiple administrations was highest for iron dextran, followed by ferumoxytol, iron gluconate, and iron sucrose.

The estimated cumulative anaphylaxis risk following total iron repletion of 1000 mg administered within a 12-week period was highest with iron dextran (82 per 100,000 persons) and lowest with iron sucrose (21 per 100,000 persons).

The researchers noted that the mechanism of anaphylactic reaction after IV iron remains unknown.

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Iron dextran drip

Photo from Flickr

Researchers have compared the risk of anaphylaxis with different intravenous (IV) iron products and found evidence to suggest that iron dextran poses the greatest risk.

Compared with nondextran formulations, iron dextran was associated with a higher cumulative risk of anaphylaxis and an increased risk of anaphylaxis at first administration.

Iron sucrose was associated with the lowest risk of anaphylaxis, both cumulative and at first administration.

Cunlin Wang, MD, PhD, of the US Food and Drug Administration in Silver Spring, Maryland, and his colleagues conducted this research and reported the results in JAMA.

The researchers studied 688,183 recipients of IV iron enrolled in the fee-for-service Medicare program from January 2003 to December 2013.

The team examined administrations of IV iron dextran, gluconate, sucrose, or ferumoxytol. They identified 247,500 iron dextran and 440,683 nondextran users during the study period.

Overall, there were 274 cases of anaphylaxis at first exposure to IV iron and an additional 170 cases during subsequent iron administrations.

At first administration, iron dextran was associated with a higher anaphylaxis risk than nondextran formulations.  The risk of anaphylaxis was 68 per 100,000 persons for iron dextran and 24 per 100,000 persons for all nondextran products combined. The odds ratio—adjusted for age, indication, history of coronary heart disease, and hypertension—was 2.6 (P<0.001).

Among the nondextran products, the risk of anaphylaxis at first administration was higher with both iron gluconate and ferumoxytol than with iron sucrose. When compared with iron sucrose, the adjusted odds ratio of anaphylaxis was 3.6 for iron dextran, 2.0 for iron gluconate, and 2.2 for ferumoxytol.

Because each IV iron product has a specific recommended dose and schedule of administration, the researchers also calculated the cumulative risk of anaphylaxis based on both the number of administrations and the clinically relevant repletion level of iron (1000 mg) achieved within 12 weeks.

The cumulative risk of anaphylaxis over multiple administrations was highest for iron dextran, followed by ferumoxytol, iron gluconate, and iron sucrose.

The estimated cumulative anaphylaxis risk following total iron repletion of 1000 mg administered within a 12-week period was highest with iron dextran (82 per 100,000 persons) and lowest with iron sucrose (21 per 100,000 persons).

The researchers noted that the mechanism of anaphylactic reaction after IV iron remains unknown.

Iron dextran drip

Photo from Flickr

Researchers have compared the risk of anaphylaxis with different intravenous (IV) iron products and found evidence to suggest that iron dextran poses the greatest risk.

Compared with nondextran formulations, iron dextran was associated with a higher cumulative risk of anaphylaxis and an increased risk of anaphylaxis at first administration.

Iron sucrose was associated with the lowest risk of anaphylaxis, both cumulative and at first administration.

Cunlin Wang, MD, PhD, of the US Food and Drug Administration in Silver Spring, Maryland, and his colleagues conducted this research and reported the results in JAMA.

The researchers studied 688,183 recipients of IV iron enrolled in the fee-for-service Medicare program from January 2003 to December 2013.

The team examined administrations of IV iron dextran, gluconate, sucrose, or ferumoxytol. They identified 247,500 iron dextran and 440,683 nondextran users during the study period.

Overall, there were 274 cases of anaphylaxis at first exposure to IV iron and an additional 170 cases during subsequent iron administrations.

At first administration, iron dextran was associated with a higher anaphylaxis risk than nondextran formulations.  The risk of anaphylaxis was 68 per 100,000 persons for iron dextran and 24 per 100,000 persons for all nondextran products combined. The odds ratio—adjusted for age, indication, history of coronary heart disease, and hypertension—was 2.6 (P<0.001).

Among the nondextran products, the risk of anaphylaxis at first administration was higher with both iron gluconate and ferumoxytol than with iron sucrose. When compared with iron sucrose, the adjusted odds ratio of anaphylaxis was 3.6 for iron dextran, 2.0 for iron gluconate, and 2.2 for ferumoxytol.

Because each IV iron product has a specific recommended dose and schedule of administration, the researchers also calculated the cumulative risk of anaphylaxis based on both the number of administrations and the clinically relevant repletion level of iron (1000 mg) achieved within 12 weeks.

The cumulative risk of anaphylaxis over multiple administrations was highest for iron dextran, followed by ferumoxytol, iron gluconate, and iron sucrose.

The estimated cumulative anaphylaxis risk following total iron repletion of 1000 mg administered within a 12-week period was highest with iron dextran (82 per 100,000 persons) and lowest with iron sucrose (21 per 100,000 persons).

The researchers noted that the mechanism of anaphylactic reaction after IV iron remains unknown.

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Project BOOST Study Is Journal of Hospital Medicine’s Top-Cited Article in 2014

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A study that examines Project BOOST’s effectiveness at decreasing rehospitalization rates was the top-cited article from the Journal of Hospital Medicine (JHM) in 2014. Titled “Project BOOST: Effectiveness of a Multihospital Effort to Reduce Rehospitalization,” the study has been cited 33 times since its publication in July 2013. The article concludes that hospitals participating in SHM’s Project BOOST (Better Outcomes for Older adults through Safe Transitions) experienced lower readmission rates.

“Project BOOST showed the effectiveness of physician-mentored implementation at reducing rehospitalization rates by improving the quality of patient care,” the study’s senior author, Mark V. Williams, MD, MHM, of Northwestern University Feinberg School of Medicine in Chicago, writes in an email to The Hospitalist eWire.

While researching the article, Dr. Williams says he knew it would be especially interesting to hospitalists. “I know hospitalists want to do the best job possible and not have patients be forced to return to the hospital because of problems with the hospital discharge process,” he writes. “Also, since hospitalists led this research as a nationwide quality improvement initiative, it is of particular interest to them.”

JHM Editor in Chief Andrew Auerbach, MD, MPH, and his editorial team publish some 30% of the 40-odd submissions they receive on average each month. “It was a very good paper,” Dr. Auerbach says of the Project BOOST study. Because of the importance of Project BOOST transitional care interventions, Dr. Auerbach and his team “knew it was going to be important to the field,” he adds.

In addition to its 33 citations, the Project BOOST article has received significant online attention. With an Altmetric score of 72, it is “one of the highest-scoring articles from [JHM] (#9 of 686),” according to its Altmetric page. This score reflects the article’s mentions in social media, newspapers, policy documents, and other sources.

Other factors such as the “number of tweets and downloads, the number of times people go to our website, those are also things that we look at very carefully to make sure that the journal is providing a service to people who may not be citing the papers but who want to use it just to read and to use in clinical care,” Dr. Auerbach says.

The four other top-cited articles discuss reducing inpatient falls, predicting mortality in ward patients through emergency medical records, detecting delirium to reduce hospitalization of dementia patients, and decreasing the use of non–evidence-based theories in treating bronchiolitis in pediatric patients.

The quality of researched published in JHM has changed since the journal’s debut in 2006, Dr. Auerbach says. “I think the field has developed quite a bit,” he adds. “I think the quality of research that’s happening in the field of hospital medicine is improving quite a bit, which is reflected in the type of papers we’re getting at the journal.”

In addition to 2014’s top-cited articles, the editorial team highlighted JHM’s new impact factor (IF) of 2.304, up from last year’s IF of 2.081. An IF indicates how many times the articles in a journal are cited elsewhere. “It is a very important metric for the journal, it’s very important for our authors, it’s important to our field,” Dr. Auerbach says. “It talks about how important the things we’re publishing are to other researchers.”

This increased IF ranks JHM 37 out of 153 journals in the General and Internal Medicine category of professional, peer-reviewed journals. Dr. Auerbach, whose five-year term will end in 2016, says he is “very happy with the pace of [JHM’s] improvement” and hopeful of the journal’s continued success. “We’re confident in our strategies,” he says. “I think if we keep focusing on really great papers and continue to grow the number of papers that come to the journal, we’ll be on track.”

 

 

Visit our website for more information on the Project BOOST study.

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A study that examines Project BOOST’s effectiveness at decreasing rehospitalization rates was the top-cited article from the Journal of Hospital Medicine (JHM) in 2014. Titled “Project BOOST: Effectiveness of a Multihospital Effort to Reduce Rehospitalization,” the study has been cited 33 times since its publication in July 2013. The article concludes that hospitals participating in SHM’s Project BOOST (Better Outcomes for Older adults through Safe Transitions) experienced lower readmission rates.

“Project BOOST showed the effectiveness of physician-mentored implementation at reducing rehospitalization rates by improving the quality of patient care,” the study’s senior author, Mark V. Williams, MD, MHM, of Northwestern University Feinberg School of Medicine in Chicago, writes in an email to The Hospitalist eWire.

While researching the article, Dr. Williams says he knew it would be especially interesting to hospitalists. “I know hospitalists want to do the best job possible and not have patients be forced to return to the hospital because of problems with the hospital discharge process,” he writes. “Also, since hospitalists led this research as a nationwide quality improvement initiative, it is of particular interest to them.”

JHM Editor in Chief Andrew Auerbach, MD, MPH, and his editorial team publish some 30% of the 40-odd submissions they receive on average each month. “It was a very good paper,” Dr. Auerbach says of the Project BOOST study. Because of the importance of Project BOOST transitional care interventions, Dr. Auerbach and his team “knew it was going to be important to the field,” he adds.

In addition to its 33 citations, the Project BOOST article has received significant online attention. With an Altmetric score of 72, it is “one of the highest-scoring articles from [JHM] (#9 of 686),” according to its Altmetric page. This score reflects the article’s mentions in social media, newspapers, policy documents, and other sources.

Other factors such as the “number of tweets and downloads, the number of times people go to our website, those are also things that we look at very carefully to make sure that the journal is providing a service to people who may not be citing the papers but who want to use it just to read and to use in clinical care,” Dr. Auerbach says.

The four other top-cited articles discuss reducing inpatient falls, predicting mortality in ward patients through emergency medical records, detecting delirium to reduce hospitalization of dementia patients, and decreasing the use of non–evidence-based theories in treating bronchiolitis in pediatric patients.

The quality of researched published in JHM has changed since the journal’s debut in 2006, Dr. Auerbach says. “I think the field has developed quite a bit,” he adds. “I think the quality of research that’s happening in the field of hospital medicine is improving quite a bit, which is reflected in the type of papers we’re getting at the journal.”

In addition to 2014’s top-cited articles, the editorial team highlighted JHM’s new impact factor (IF) of 2.304, up from last year’s IF of 2.081. An IF indicates how many times the articles in a journal are cited elsewhere. “It is a very important metric for the journal, it’s very important for our authors, it’s important to our field,” Dr. Auerbach says. “It talks about how important the things we’re publishing are to other researchers.”

This increased IF ranks JHM 37 out of 153 journals in the General and Internal Medicine category of professional, peer-reviewed journals. Dr. Auerbach, whose five-year term will end in 2016, says he is “very happy with the pace of [JHM’s] improvement” and hopeful of the journal’s continued success. “We’re confident in our strategies,” he says. “I think if we keep focusing on really great papers and continue to grow the number of papers that come to the journal, we’ll be on track.”

 

 

Visit our website for more information on the Project BOOST study.

A study that examines Project BOOST’s effectiveness at decreasing rehospitalization rates was the top-cited article from the Journal of Hospital Medicine (JHM) in 2014. Titled “Project BOOST: Effectiveness of a Multihospital Effort to Reduce Rehospitalization,” the study has been cited 33 times since its publication in July 2013. The article concludes that hospitals participating in SHM’s Project BOOST (Better Outcomes for Older adults through Safe Transitions) experienced lower readmission rates.

“Project BOOST showed the effectiveness of physician-mentored implementation at reducing rehospitalization rates by improving the quality of patient care,” the study’s senior author, Mark V. Williams, MD, MHM, of Northwestern University Feinberg School of Medicine in Chicago, writes in an email to The Hospitalist eWire.

While researching the article, Dr. Williams says he knew it would be especially interesting to hospitalists. “I know hospitalists want to do the best job possible and not have patients be forced to return to the hospital because of problems with the hospital discharge process,” he writes. “Also, since hospitalists led this research as a nationwide quality improvement initiative, it is of particular interest to them.”

JHM Editor in Chief Andrew Auerbach, MD, MPH, and his editorial team publish some 30% of the 40-odd submissions they receive on average each month. “It was a very good paper,” Dr. Auerbach says of the Project BOOST study. Because of the importance of Project BOOST transitional care interventions, Dr. Auerbach and his team “knew it was going to be important to the field,” he adds.

In addition to its 33 citations, the Project BOOST article has received significant online attention. With an Altmetric score of 72, it is “one of the highest-scoring articles from [JHM] (#9 of 686),” according to its Altmetric page. This score reflects the article’s mentions in social media, newspapers, policy documents, and other sources.

Other factors such as the “number of tweets and downloads, the number of times people go to our website, those are also things that we look at very carefully to make sure that the journal is providing a service to people who may not be citing the papers but who want to use it just to read and to use in clinical care,” Dr. Auerbach says.

The four other top-cited articles discuss reducing inpatient falls, predicting mortality in ward patients through emergency medical records, detecting delirium to reduce hospitalization of dementia patients, and decreasing the use of non–evidence-based theories in treating bronchiolitis in pediatric patients.

The quality of researched published in JHM has changed since the journal’s debut in 2006, Dr. Auerbach says. “I think the field has developed quite a bit,” he adds. “I think the quality of research that’s happening in the field of hospital medicine is improving quite a bit, which is reflected in the type of papers we’re getting at the journal.”

In addition to 2014’s top-cited articles, the editorial team highlighted JHM’s new impact factor (IF) of 2.304, up from last year’s IF of 2.081. An IF indicates how many times the articles in a journal are cited elsewhere. “It is a very important metric for the journal, it’s very important for our authors, it’s important to our field,” Dr. Auerbach says. “It talks about how important the things we’re publishing are to other researchers.”

This increased IF ranks JHM 37 out of 153 journals in the General and Internal Medicine category of professional, peer-reviewed journals. Dr. Auerbach, whose five-year term will end in 2016, says he is “very happy with the pace of [JHM’s] improvement” and hopeful of the journal’s continued success. “We’re confident in our strategies,” he says. “I think if we keep focusing on really great papers and continue to grow the number of papers that come to the journal, we’ll be on track.”

 

 

Visit our website for more information on the Project BOOST study.

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The ongoing sea change in medicine has led to a substantial erosion of physician autonomy and to ever-increasing administrative burdens that hit small practices the hardest. Does this mean that the independent private physician practice model is doomed, as some predict? Absolutely not; but it will force many solo practitioners and small groups to join forces to protect themselves.

Those practices that offer unique services, or fill an unmet niche, may be able to remain small; but most smaller practices will need to consider a larger alternative. In my last column, I outlined the basics of arriving at a fair market value for a private practice; once that has been accomplished, you will be in a position to consider the various merger options that are available.

Dr. Joseph S. Eastern

One attractive and relatively straightforward strategy is the formation of a cooperative group. In most areas, there are very likely several small practices in similar predicaments that might be receptive to discussing a collaboration on billing and purchasing. This allows each participant to maintain independence as a private practice, while pooling resources to ease the administrative burdens of all. Once that arrangement is in place, the group can consider more ambitious projects, such as the joint purchase of an integrated electronic health records (EHR) network, sharing personnel to lower staffing costs, and an integrated scheduling system. The latter will be particularly attractive to participants in later stages of their careers who are considering an intermediate option, somewhere between full-time work and complete retirement.

After a time, when the structure is stabilized and everyone agrees that his or her individual and shared interests and goals are being met, an outright merger can be contemplated. Obviously, projects of this scope require careful planning and implementation, and should not be undertaken without the help of competent legal counsel and an experienced business consultant.

A more complex but increasingly popular option is to join other small practices and providers in an independent practice association. An IPA is a legal entity, organized and directed by physicians for the purpose of negotiating contracts with insurance companies on their behalf. Because of its structure, an IPA is better positioned to enter into such financial arrangements and to counterbalance the leverage of insurers; but there are legal issues to consider. Many IPAs are vulnerable to antitrust charges because they include competing health care providers. You should check with legal counsel before signing on to an IPA, to make sure that it abides by antitrust and price fixing laws. IPAs have also been known to fail, particularly in states where they are not adequately regulated.

One proposed successor to the IPA is the accountable care organization (ACO), an entity born as a component of the Affordable Care Act. While the official definition remains nebulous, an ACO is basically a network of doctors and hospitals that shares financial and medical responsibility for providing coordinated and efficient care to patients. The goal of ACO participators is to limit unnecessary spending, both individually and collectively, according to criteria established by the Centers for Medicare & Medicaid Services (CMS), without compromising quality of care in the process. More than 600 ACOs had been approved by the CMS as of the beginning of 2014.

As the name implies, ACOs make providers jointly accountable for the health of their patients; they offer financial incentives to cooperate and to save money by avoiding unnecessary tests and procedures. A key component is the sharing of information. Providers that save money while also meeting quality targets are theoretically entitled to a portion of the savings.

As with IPAs, ACO ventures involve a measure of risk. ACOs that fail to meet the CMS performance and savings benchmarks can be stuck with the bill for investments made to improve care, such as equipment and computer purchases, and the hiring of mid-level providers and managers, and may be assessed monetary penalties as well. ACOs sponsored by physicians or rural providers, however, can apply to receive payments in advance to help finance infrastructure investments – a concession the Obama administration made after receiving complaints from rural hospitals. It is important to remember that the ACO model remains very much a work in progress.

Clearly, the price of remaining autonomous will be significant, and many private practitioners will be unwilling to pay it: Only 36% of physicians remained in independent practice at the end of the 2013, according to data from the American Medical Association – down from 57% in 2000; but those of us who remain committed to independence will find ways to preserve it, by mergers or other methods. In medicine, as in life, those most responsive to change will survive and flourish.

 

 

Dr. Eastern practices dermatology and dermatologic surgery in Belleville, N.J. He is the author of numerous articles and textbook chapters, and is a longtime monthly columnist for Dermatology News. Write to him at [email protected].

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The ongoing sea change in medicine has led to a substantial erosion of physician autonomy and to ever-increasing administrative burdens that hit small practices the hardest. Does this mean that the independent private physician practice model is doomed, as some predict? Absolutely not; but it will force many solo practitioners and small groups to join forces to protect themselves.

Those practices that offer unique services, or fill an unmet niche, may be able to remain small; but most smaller practices will need to consider a larger alternative. In my last column, I outlined the basics of arriving at a fair market value for a private practice; once that has been accomplished, you will be in a position to consider the various merger options that are available.

Dr. Joseph S. Eastern

One attractive and relatively straightforward strategy is the formation of a cooperative group. In most areas, there are very likely several small practices in similar predicaments that might be receptive to discussing a collaboration on billing and purchasing. This allows each participant to maintain independence as a private practice, while pooling resources to ease the administrative burdens of all. Once that arrangement is in place, the group can consider more ambitious projects, such as the joint purchase of an integrated electronic health records (EHR) network, sharing personnel to lower staffing costs, and an integrated scheduling system. The latter will be particularly attractive to participants in later stages of their careers who are considering an intermediate option, somewhere between full-time work and complete retirement.

After a time, when the structure is stabilized and everyone agrees that his or her individual and shared interests and goals are being met, an outright merger can be contemplated. Obviously, projects of this scope require careful planning and implementation, and should not be undertaken without the help of competent legal counsel and an experienced business consultant.

A more complex but increasingly popular option is to join other small practices and providers in an independent practice association. An IPA is a legal entity, organized and directed by physicians for the purpose of negotiating contracts with insurance companies on their behalf. Because of its structure, an IPA is better positioned to enter into such financial arrangements and to counterbalance the leverage of insurers; but there are legal issues to consider. Many IPAs are vulnerable to antitrust charges because they include competing health care providers. You should check with legal counsel before signing on to an IPA, to make sure that it abides by antitrust and price fixing laws. IPAs have also been known to fail, particularly in states where they are not adequately regulated.

One proposed successor to the IPA is the accountable care organization (ACO), an entity born as a component of the Affordable Care Act. While the official definition remains nebulous, an ACO is basically a network of doctors and hospitals that shares financial and medical responsibility for providing coordinated and efficient care to patients. The goal of ACO participators is to limit unnecessary spending, both individually and collectively, according to criteria established by the Centers for Medicare & Medicaid Services (CMS), without compromising quality of care in the process. More than 600 ACOs had been approved by the CMS as of the beginning of 2014.

As the name implies, ACOs make providers jointly accountable for the health of their patients; they offer financial incentives to cooperate and to save money by avoiding unnecessary tests and procedures. A key component is the sharing of information. Providers that save money while also meeting quality targets are theoretically entitled to a portion of the savings.

As with IPAs, ACO ventures involve a measure of risk. ACOs that fail to meet the CMS performance and savings benchmarks can be stuck with the bill for investments made to improve care, such as equipment and computer purchases, and the hiring of mid-level providers and managers, and may be assessed monetary penalties as well. ACOs sponsored by physicians or rural providers, however, can apply to receive payments in advance to help finance infrastructure investments – a concession the Obama administration made after receiving complaints from rural hospitals. It is important to remember that the ACO model remains very much a work in progress.

Clearly, the price of remaining autonomous will be significant, and many private practitioners will be unwilling to pay it: Only 36% of physicians remained in independent practice at the end of the 2013, according to data from the American Medical Association – down from 57% in 2000; but those of us who remain committed to independence will find ways to preserve it, by mergers or other methods. In medicine, as in life, those most responsive to change will survive and flourish.

 

 

Dr. Eastern practices dermatology and dermatologic surgery in Belleville, N.J. He is the author of numerous articles and textbook chapters, and is a longtime monthly columnist for Dermatology News. Write to him at [email protected].

The ongoing sea change in medicine has led to a substantial erosion of physician autonomy and to ever-increasing administrative burdens that hit small practices the hardest. Does this mean that the independent private physician practice model is doomed, as some predict? Absolutely not; but it will force many solo practitioners and small groups to join forces to protect themselves.

Those practices that offer unique services, or fill an unmet niche, may be able to remain small; but most smaller practices will need to consider a larger alternative. In my last column, I outlined the basics of arriving at a fair market value for a private practice; once that has been accomplished, you will be in a position to consider the various merger options that are available.

Dr. Joseph S. Eastern

One attractive and relatively straightforward strategy is the formation of a cooperative group. In most areas, there are very likely several small practices in similar predicaments that might be receptive to discussing a collaboration on billing and purchasing. This allows each participant to maintain independence as a private practice, while pooling resources to ease the administrative burdens of all. Once that arrangement is in place, the group can consider more ambitious projects, such as the joint purchase of an integrated electronic health records (EHR) network, sharing personnel to lower staffing costs, and an integrated scheduling system. The latter will be particularly attractive to participants in later stages of their careers who are considering an intermediate option, somewhere between full-time work and complete retirement.

After a time, when the structure is stabilized and everyone agrees that his or her individual and shared interests and goals are being met, an outright merger can be contemplated. Obviously, projects of this scope require careful planning and implementation, and should not be undertaken without the help of competent legal counsel and an experienced business consultant.

A more complex but increasingly popular option is to join other small practices and providers in an independent practice association. An IPA is a legal entity, organized and directed by physicians for the purpose of negotiating contracts with insurance companies on their behalf. Because of its structure, an IPA is better positioned to enter into such financial arrangements and to counterbalance the leverage of insurers; but there are legal issues to consider. Many IPAs are vulnerable to antitrust charges because they include competing health care providers. You should check with legal counsel before signing on to an IPA, to make sure that it abides by antitrust and price fixing laws. IPAs have also been known to fail, particularly in states where they are not adequately regulated.

One proposed successor to the IPA is the accountable care organization (ACO), an entity born as a component of the Affordable Care Act. While the official definition remains nebulous, an ACO is basically a network of doctors and hospitals that shares financial and medical responsibility for providing coordinated and efficient care to patients. The goal of ACO participators is to limit unnecessary spending, both individually and collectively, according to criteria established by the Centers for Medicare & Medicaid Services (CMS), without compromising quality of care in the process. More than 600 ACOs had been approved by the CMS as of the beginning of 2014.

As the name implies, ACOs make providers jointly accountable for the health of their patients; they offer financial incentives to cooperate and to save money by avoiding unnecessary tests and procedures. A key component is the sharing of information. Providers that save money while also meeting quality targets are theoretically entitled to a portion of the savings.

As with IPAs, ACO ventures involve a measure of risk. ACOs that fail to meet the CMS performance and savings benchmarks can be stuck with the bill for investments made to improve care, such as equipment and computer purchases, and the hiring of mid-level providers and managers, and may be assessed monetary penalties as well. ACOs sponsored by physicians or rural providers, however, can apply to receive payments in advance to help finance infrastructure investments – a concession the Obama administration made after receiving complaints from rural hospitals. It is important to remember that the ACO model remains very much a work in progress.

Clearly, the price of remaining autonomous will be significant, and many private practitioners will be unwilling to pay it: Only 36% of physicians remained in independent practice at the end of the 2013, according to data from the American Medical Association – down from 57% in 2000; but those of us who remain committed to independence will find ways to preserve it, by mergers or other methods. In medicine, as in life, those most responsive to change will survive and flourish.

 

 

Dr. Eastern practices dermatology and dermatologic surgery in Belleville, N.J. He is the author of numerous articles and textbook chapters, and is a longtime monthly columnist for Dermatology News. Write to him at [email protected].

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Nursing Care Top-Ranked Factor in Pediatric Inpatient Satisfaction Survey

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A recent patient satisfaction survey that ranked nursing care as the most important factor within inpatient pediatric care settings comes as no surprise to the chair of SHM’s Nurse Practitioner/Physician Assistant Committee.

Published online last month in the American Journal of Medical Quality, the retrospective study found that patient satisfaction for pediatric care varies widely depending on “which departmental setting patients receive treatment within a healthcare system,” study authors noted.

“Communication is one of the most important things,” says committee chair Tracy Cardin, ACNP-BC, FHM. “And nursing is sort of our designee sometimes in the communication of the plan of care. You can go over something with a patient and the family for a minute or so, or five, or even 10. But, really, it’s the nurses who reinforce the message.”

For the study, researchers at Nemours/Alfred I. duPont Hospital for Children in Delaware reviewed more than 27,000 patient satisfaction survey results over a three-year period at facilities of the Nemours Children’s Health System in the Delaware Valley and Jefferson University Hospitals in Philadelphia. Families rated their satisfaction on a five-point scale for various factors including physician care, nurse care, and personal concern.

The researchers say knowing what kinds of care expectations patients have in different settings, be it the emergency department or an inpatient ward, could help tailor interventions.

Cardin is hopeful that’s true, but she notes that patient satisfaction is a complex issue. A hospitalist could deliver perfect care, but if the patient had a bad experience at the hospital’s front door, the actual care delivery scores may be affected.

“It would be nice if there were just one variable to manipulate,” she says. “There are so many different impacts on [satisfaction]. What do we really have the ability to control?”

View our website for more information on inpatient satisfaction.

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A recent patient satisfaction survey that ranked nursing care as the most important factor within inpatient pediatric care settings comes as no surprise to the chair of SHM’s Nurse Practitioner/Physician Assistant Committee.

Published online last month in the American Journal of Medical Quality, the retrospective study found that patient satisfaction for pediatric care varies widely depending on “which departmental setting patients receive treatment within a healthcare system,” study authors noted.

“Communication is one of the most important things,” says committee chair Tracy Cardin, ACNP-BC, FHM. “And nursing is sort of our designee sometimes in the communication of the plan of care. You can go over something with a patient and the family for a minute or so, or five, or even 10. But, really, it’s the nurses who reinforce the message.”

For the study, researchers at Nemours/Alfred I. duPont Hospital for Children in Delaware reviewed more than 27,000 patient satisfaction survey results over a three-year period at facilities of the Nemours Children’s Health System in the Delaware Valley and Jefferson University Hospitals in Philadelphia. Families rated their satisfaction on a five-point scale for various factors including physician care, nurse care, and personal concern.

The researchers say knowing what kinds of care expectations patients have in different settings, be it the emergency department or an inpatient ward, could help tailor interventions.

Cardin is hopeful that’s true, but she notes that patient satisfaction is a complex issue. A hospitalist could deliver perfect care, but if the patient had a bad experience at the hospital’s front door, the actual care delivery scores may be affected.

“It would be nice if there were just one variable to manipulate,” she says. “There are so many different impacts on [satisfaction]. What do we really have the ability to control?”

View our website for more information on inpatient satisfaction.

A recent patient satisfaction survey that ranked nursing care as the most important factor within inpatient pediatric care settings comes as no surprise to the chair of SHM’s Nurse Practitioner/Physician Assistant Committee.

Published online last month in the American Journal of Medical Quality, the retrospective study found that patient satisfaction for pediatric care varies widely depending on “which departmental setting patients receive treatment within a healthcare system,” study authors noted.

“Communication is one of the most important things,” says committee chair Tracy Cardin, ACNP-BC, FHM. “And nursing is sort of our designee sometimes in the communication of the plan of care. You can go over something with a patient and the family for a minute or so, or five, or even 10. But, really, it’s the nurses who reinforce the message.”

For the study, researchers at Nemours/Alfred I. duPont Hospital for Children in Delaware reviewed more than 27,000 patient satisfaction survey results over a three-year period at facilities of the Nemours Children’s Health System in the Delaware Valley and Jefferson University Hospitals in Philadelphia. Families rated their satisfaction on a five-point scale for various factors including physician care, nurse care, and personal concern.

The researchers say knowing what kinds of care expectations patients have in different settings, be it the emergency department or an inpatient ward, could help tailor interventions.

Cardin is hopeful that’s true, but she notes that patient satisfaction is a complex issue. A hospitalist could deliver perfect care, but if the patient had a bad experience at the hospital’s front door, the actual care delivery scores may be affected.

“It would be nice if there were just one variable to manipulate,” she says. “There are so many different impacts on [satisfaction]. What do we really have the ability to control?”

View our website for more information on inpatient satisfaction.

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Difference in the timing of cessation of palliative chemotherapy between patients with incurable cancer receiving therapy only in a local hospital and those transitioned from a tertiary medical center to a local hospital

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Difference in the timing of cessation of palliative chemotherapy between patients with incurable cancer receiving therapy only in a local hospital and those transitioned from a tertiary medical center to a local hospital
Background It is important to know when to decide to end palliative chemotherapy (PC) for the quality of life of patients. However, there is currently no clear agreement on when to terminate PC.

 

Objectives To determine whether the difference of the period between the completion of PC and death affects patients’ trajectory of supportive care near end of life.

 

Methods This retrospective study included 52 adult patients with incurable cancer who had received PC and who were referred to our palliative care team and died in our local hospital between July 2011 and June 2014. Group A comprised patients who received anticancer therapy such as surgery and PC only in our hospital and eventually died there. Group B comprised patients who were transitioned to our hospital from tertiary medical centers after cessation of PC.

 

Results 17 of 22 patients (77%) in Group A conveyed the intention of continuing PC in the first interview with a physician of the palliative care team, whereas 4 of 30 patients (13%) in Group B conveyed a similar intention. The patients in Group B stopped PC a median of 43 days earlier than did the patients in Group A (P < .0001).

 

Conclusions These data showed that more patients in Group A wanted to continue PC and had a shorter interval between last PC and death. Change in the hospital where the patients are given supportive care might contribute to the cessation of futile PC at an appropriate time.  

 

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Background It is important to know when to decide to end palliative chemotherapy (PC) for the quality of life of patients. However, there is currently no clear agreement on when to terminate PC.

 

Objectives To determine whether the difference of the period between the completion of PC and death affects patients’ trajectory of supportive care near end of life.

 

Methods This retrospective study included 52 adult patients with incurable cancer who had received PC and who were referred to our palliative care team and died in our local hospital between July 2011 and June 2014. Group A comprised patients who received anticancer therapy such as surgery and PC only in our hospital and eventually died there. Group B comprised patients who were transitioned to our hospital from tertiary medical centers after cessation of PC.

 

Results 17 of 22 patients (77%) in Group A conveyed the intention of continuing PC in the first interview with a physician of the palliative care team, whereas 4 of 30 patients (13%) in Group B conveyed a similar intention. The patients in Group B stopped PC a median of 43 days earlier than did the patients in Group A (P < .0001).

 

Conclusions These data showed that more patients in Group A wanted to continue PC and had a shorter interval between last PC and death. Change in the hospital where the patients are given supportive care might contribute to the cessation of futile PC at an appropriate time.  

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Background It is important to know when to decide to end palliative chemotherapy (PC) for the quality of life of patients. However, there is currently no clear agreement on when to terminate PC.

 

Objectives To determine whether the difference of the period between the completion of PC and death affects patients’ trajectory of supportive care near end of life.

 

Methods This retrospective study included 52 adult patients with incurable cancer who had received PC and who were referred to our palliative care team and died in our local hospital between July 2011 and June 2014. Group A comprised patients who received anticancer therapy such as surgery and PC only in our hospital and eventually died there. Group B comprised patients who were transitioned to our hospital from tertiary medical centers after cessation of PC.

 

Results 17 of 22 patients (77%) in Group A conveyed the intention of continuing PC in the first interview with a physician of the palliative care team, whereas 4 of 30 patients (13%) in Group B conveyed a similar intention. The patients in Group B stopped PC a median of 43 days earlier than did the patients in Group A (P < .0001).

 

Conclusions These data showed that more patients in Group A wanted to continue PC and had a shorter interval between last PC and death. Change in the hospital where the patients are given supportive care might contribute to the cessation of futile PC at an appropriate time.  

 

Click on the PDF icon at the top of this introduction to read the full article.

 

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Impact of inpatient radiation on length of stay and health care costs

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Impact of inpatient radiation on length of stay and health care costs

Background Health care costs are rising. Identifying areas for health care utilization savings may reduce costs.

Objective To identify oncology patients receiving inpatient radiotherapy with the purpose of measuring length of stay (LoS) and hospital charges.

Methods During July 2013 the oncology service physicians at Mount Sinai Medical Center in New York City were surveyed daily to identify patients receiving inpatient radiation. Actual LoS, acuity LoS were determined from the chart review. Expected LoS was calculated using the University Healthsystem Consortium database. Charges associated with actual LoS, acuity LoS, and expected LoS were then reported. Actual and expected LoS were compared for inpatient radiotherapy and nonradiotherapy groups.

Results 7 patients were identified as having remained in the hospital to receive radiation treatment. In that cohort, the average actual LoS and charges per patient were 40.1 and $48,724, compared with acuity LoS and charges of 25.6 days and $34,089 and expected LoS and charges of 7.7 days and $10,028. Mean LoS and charges attributed to radiation alone amounted to 11 days and $12,514. The mean actual LoS of oncology patients admitted during the same time period who did not receive radiation was 6.7 days, compared with 40.1 days for patients who received radiation (P < .0001).

Limitations Inability to access actual reimbursement data prevented exact cost calculations, small sample size, and single-institution focus.

Conclusion Delivery of radiation therapy during inpatient hospitalization extends LoS and contributes to higher health care costs. Methods to facilitate the delivery of outpatient radiotherapy may result in cost savings.

 

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Background Health care costs are rising. Identifying areas for health care utilization savings may reduce costs.

Objective To identify oncology patients receiving inpatient radiotherapy with the purpose of measuring length of stay (LoS) and hospital charges.

Methods During July 2013 the oncology service physicians at Mount Sinai Medical Center in New York City were surveyed daily to identify patients receiving inpatient radiation. Actual LoS, acuity LoS were determined from the chart review. Expected LoS was calculated using the University Healthsystem Consortium database. Charges associated with actual LoS, acuity LoS, and expected LoS were then reported. Actual and expected LoS were compared for inpatient radiotherapy and nonradiotherapy groups.

Results 7 patients were identified as having remained in the hospital to receive radiation treatment. In that cohort, the average actual LoS and charges per patient were 40.1 and $48,724, compared with acuity LoS and charges of 25.6 days and $34,089 and expected LoS and charges of 7.7 days and $10,028. Mean LoS and charges attributed to radiation alone amounted to 11 days and $12,514. The mean actual LoS of oncology patients admitted during the same time period who did not receive radiation was 6.7 days, compared with 40.1 days for patients who received radiation (P < .0001).

Limitations Inability to access actual reimbursement data prevented exact cost calculations, small sample size, and single-institution focus.

Conclusion Delivery of radiation therapy during inpatient hospitalization extends LoS and contributes to higher health care costs. Methods to facilitate the delivery of outpatient radiotherapy may result in cost savings.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Background Health care costs are rising. Identifying areas for health care utilization savings may reduce costs.

Objective To identify oncology patients receiving inpatient radiotherapy with the purpose of measuring length of stay (LoS) and hospital charges.

Methods During July 2013 the oncology service physicians at Mount Sinai Medical Center in New York City were surveyed daily to identify patients receiving inpatient radiation. Actual LoS, acuity LoS were determined from the chart review. Expected LoS was calculated using the University Healthsystem Consortium database. Charges associated with actual LoS, acuity LoS, and expected LoS were then reported. Actual and expected LoS were compared for inpatient radiotherapy and nonradiotherapy groups.

Results 7 patients were identified as having remained in the hospital to receive radiation treatment. In that cohort, the average actual LoS and charges per patient were 40.1 and $48,724, compared with acuity LoS and charges of 25.6 days and $34,089 and expected LoS and charges of 7.7 days and $10,028. Mean LoS and charges attributed to radiation alone amounted to 11 days and $12,514. The mean actual LoS of oncology patients admitted during the same time period who did not receive radiation was 6.7 days, compared with 40.1 days for patients who received radiation (P < .0001).

Limitations Inability to access actual reimbursement data prevented exact cost calculations, small sample size, and single-institution focus.

Conclusion Delivery of radiation therapy during inpatient hospitalization extends LoS and contributes to higher health care costs. Methods to facilitate the delivery of outpatient radiotherapy may result in cost savings.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

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Caregivers’ attitudes toward promoting exercise among patients with late-stage lung cancer

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Caregivers’ attitudes toward promoting exercise among patients with late-stage lung cancer
Background The benefits of exercise, even at low intensity levels, in improving overall health, psychological well-being, and quality of life in patients with cancer have been well documented. However, few patients are involved in formal exercise programs, and little is known about the factors that motivate those who do participate. Although it has not been well assessed, it stands to reason that spousal and family support is an important determinant of cancer patients’ adoption of, and adherence to, an exercise program.

 

Objective To characterize attitudes among the family caregivers of patients with late-stage lung cancer about their role in promoting exercise.

 

Methods 20 adult family caregivers of patients with stage IIIB or IV non-small-cell lung cancer were asked during semi-structured interviews about their views on the role of exercise in “fighting cancer,” whether with respect to survival, health, psychological well-being, or overall quality of life; their ability to encourage patients to exercise; and their receptivity to getting exercise instructions from health care providers.

 

Findings Family caregivers viewed exercise as important in fighting cancer. Past exercise patterns and lifestyle were important considerations, with some family caregivers who had not previously exercised considering household activities sufficient for promoting fitness. Family caregivers emphasized the importance of knowing the established boundaries of their relationships and respecting patients’ autonomy. Caregivers generally thought that direction from health care providers to exercise would more likely result in meaningful behavioral change for patients.

 

Limitations The participants were recruited from a quaternary medical center and restricted to those with lung cancer, which may limit the generalizability of the findings to other settings or cancers.

 

Conclusions and interpretation Family caregivers believe that exercise is important for patients, but feel constrained in their willingness and ability to promote exercise behaviors because of the established boundaries of their relationships. They have mixed opinions about the utility of exercise promotion by health care providers. Family caregivers are ambivalent about promoting exercise for patients with advanced cancer. Nonjudgmental assessment of patients’ past exercise preferences and established relationship boundaries should inform clinical judgment about the utility of engaging family caregivers in the promotion of exercise.

 

Funding/support Dr Cheville reports support from a grant (NIH R01 11-008151).

 

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392-398
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Background The benefits of exercise, even at low intensity levels, in improving overall health, psychological well-being, and quality of life in patients with cancer have been well documented. However, few patients are involved in formal exercise programs, and little is known about the factors that motivate those who do participate. Although it has not been well assessed, it stands to reason that spousal and family support is an important determinant of cancer patients’ adoption of, and adherence to, an exercise program.

 

Objective To characterize attitudes among the family caregivers of patients with late-stage lung cancer about their role in promoting exercise.

 

Methods 20 adult family caregivers of patients with stage IIIB or IV non-small-cell lung cancer were asked during semi-structured interviews about their views on the role of exercise in “fighting cancer,” whether with respect to survival, health, psychological well-being, or overall quality of life; their ability to encourage patients to exercise; and their receptivity to getting exercise instructions from health care providers.

 

Findings Family caregivers viewed exercise as important in fighting cancer. Past exercise patterns and lifestyle were important considerations, with some family caregivers who had not previously exercised considering household activities sufficient for promoting fitness. Family caregivers emphasized the importance of knowing the established boundaries of their relationships and respecting patients’ autonomy. Caregivers generally thought that direction from health care providers to exercise would more likely result in meaningful behavioral change for patients.

 

Limitations The participants were recruited from a quaternary medical center and restricted to those with lung cancer, which may limit the generalizability of the findings to other settings or cancers.

 

Conclusions and interpretation Family caregivers believe that exercise is important for patients, but feel constrained in their willingness and ability to promote exercise behaviors because of the established boundaries of their relationships. They have mixed opinions about the utility of exercise promotion by health care providers. Family caregivers are ambivalent about promoting exercise for patients with advanced cancer. Nonjudgmental assessment of patients’ past exercise preferences and established relationship boundaries should inform clinical judgment about the utility of engaging family caregivers in the promotion of exercise.

 

Funding/support Dr Cheville reports support from a grant (NIH R01 11-008151).

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Background The benefits of exercise, even at low intensity levels, in improving overall health, psychological well-being, and quality of life in patients with cancer have been well documented. However, few patients are involved in formal exercise programs, and little is known about the factors that motivate those who do participate. Although it has not been well assessed, it stands to reason that spousal and family support is an important determinant of cancer patients’ adoption of, and adherence to, an exercise program.

 

Objective To characterize attitudes among the family caregivers of patients with late-stage lung cancer about their role in promoting exercise.

 

Methods 20 adult family caregivers of patients with stage IIIB or IV non-small-cell lung cancer were asked during semi-structured interviews about their views on the role of exercise in “fighting cancer,” whether with respect to survival, health, psychological well-being, or overall quality of life; their ability to encourage patients to exercise; and their receptivity to getting exercise instructions from health care providers.

 

Findings Family caregivers viewed exercise as important in fighting cancer. Past exercise patterns and lifestyle were important considerations, with some family caregivers who had not previously exercised considering household activities sufficient for promoting fitness. Family caregivers emphasized the importance of knowing the established boundaries of their relationships and respecting patients’ autonomy. Caregivers generally thought that direction from health care providers to exercise would more likely result in meaningful behavioral change for patients.

 

Limitations The participants were recruited from a quaternary medical center and restricted to those with lung cancer, which may limit the generalizability of the findings to other settings or cancers.

 

Conclusions and interpretation Family caregivers believe that exercise is important for patients, but feel constrained in their willingness and ability to promote exercise behaviors because of the established boundaries of their relationships. They have mixed opinions about the utility of exercise promotion by health care providers. Family caregivers are ambivalent about promoting exercise for patients with advanced cancer. Nonjudgmental assessment of patients’ past exercise preferences and established relationship boundaries should inform clinical judgment about the utility of engaging family caregivers in the promotion of exercise.

 

Funding/support Dr Cheville reports support from a grant (NIH R01 11-008151).

 

Click on the PDF icon at the top of this introduction to read the full article.

 

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Gout hospitalizations, costs surpass those for rheumatoid arthritis

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Gout hospitalizations, costs surpass those for rheumatoid arthritis

SAN FRANCISCO – Hospitalization rates for gout doubled between 1993 and 2011, while those for rheumatoid arthritis fell by 67%, Dr. Sian Yik Lim reported at the annual meeting of the American College of Rheumatology.

The trends reveal marked progress in the treatment of rheumatoid arthritis, but “also highlight a critical need to improve gout care” and to implement measures to combat its rising prevalence, said Dr. Lim, a research fellow in medicine at Massachusetts General Hospital, Boston.

The study is “a very nice piece of work,” added Dr. James Galloway, who helped moderate the session at the meeting and is a lecturer in rheumatology at King’s College Hospital in London. “It makes us wonder whether we should spend more time teaching our primary care physician colleagues more about gout than rheumatoid arthritis.”

©Kimberly Pack/Thinkstock.com

Gout and rheumatoid arthritis are the two most common inflammatory joint diseases, but few longitudinal studies have examined trends in related hospital admissions or costs, Dr. Lim said. Therefore, he and his associates extracted primary hospital discharge ICD-9 diagnosis codes from the National Inpatient Sample and also studied primary procedure codes for total knee replacement, total hip replacement, and other major joint surgeries for 1993 through 2011. In addition, they merged these with cost data from the Healthcare Cost and Utilization Project for 2001 to 2011.

Hospitalizations for gout and rheumatoid arthritis “crisscrossed” during the study period, Dr. Lim said. While there were more than three times as many hospitalizations for rheumatoid arthritis (26,712) as for gout (8,485) in 1993, by 2011, there were nearly twice as many admissions for gout (20,949) as for rheumatoid arthritis (11,015). Likewise, hospitalization rates for gout rose from 4.5 to 9 per 100,000 adults, while rheumatoid arthritis admissions fell by about two-thirds, from 14 to 5 per 100,000 adults. For the entire study period, hospital admissions for gout totaled 254,982, compared with 323,649 for rheumatoid arthritis, Dr. Lim added.

The investigators also documented a steady drop in admissions for total knee replacement, total hip replacement, and other major joint surgeries among rheumatoid arthritis patients, mirroring the results of recent multicenter studies in California (Ann Rheum Dis. 2009 Jul 5. doi: 10.1136/ard.2009.112474), the United Kingdom (Rheumatology [Oxford]. 2015 Apr;54[4]:666-71), and Germany (Ann Rheum Dis. 2015;74:738-45), Dr. Lim said. “This finding contrasts with the overall dramatic increase in these surgeries in the general United States population in recent years,” he added.

Inflation-adjusted hospital costs for gout and rheumatoid arthritis also converged during the study period, and by 2011, costs for gout actually exceeded those for rheumatoid arthritis, Dr. Lim said.

Overall, the findings reflect stark differences in care for gout and rheumatoid arthritis in the United States, he added. “New and potent drugs, effective combination regimens, and management strategies are increasingly being adopted for rheumatoid arthritis, but care for gout remains suboptimal, even though its prevalence and incidence are increasing,” he said. “Although the vast majority of gout patients are indicated for urate-lowering therapy, only a small proportion retrieve treatment, and the level of uric acid is not even measured in the vast majority of patients.”

Surveys also indicate that patients with gout often do not receive clear explanations about their disease, which may explain why as few as 10% follow treatment recommendations, according to Dr. Lim. He pointed to a hospital-based, retrospective cohort study reported at last year’s ACR annual meeting in which 89% of hospitalizations for gout were considered preventable. “These data support the need to improve gout prevention and care,” he said.

Dr. Lim had no disclosures. Dr. Hyon Choi, the senior author, reported having served on advisory boards for Takeda and AstraZeneca.

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SAN FRANCISCO – Hospitalization rates for gout doubled between 1993 and 2011, while those for rheumatoid arthritis fell by 67%, Dr. Sian Yik Lim reported at the annual meeting of the American College of Rheumatology.

The trends reveal marked progress in the treatment of rheumatoid arthritis, but “also highlight a critical need to improve gout care” and to implement measures to combat its rising prevalence, said Dr. Lim, a research fellow in medicine at Massachusetts General Hospital, Boston.

The study is “a very nice piece of work,” added Dr. James Galloway, who helped moderate the session at the meeting and is a lecturer in rheumatology at King’s College Hospital in London. “It makes us wonder whether we should spend more time teaching our primary care physician colleagues more about gout than rheumatoid arthritis.”

©Kimberly Pack/Thinkstock.com

Gout and rheumatoid arthritis are the two most common inflammatory joint diseases, but few longitudinal studies have examined trends in related hospital admissions or costs, Dr. Lim said. Therefore, he and his associates extracted primary hospital discharge ICD-9 diagnosis codes from the National Inpatient Sample and also studied primary procedure codes for total knee replacement, total hip replacement, and other major joint surgeries for 1993 through 2011. In addition, they merged these with cost data from the Healthcare Cost and Utilization Project for 2001 to 2011.

Hospitalizations for gout and rheumatoid arthritis “crisscrossed” during the study period, Dr. Lim said. While there were more than three times as many hospitalizations for rheumatoid arthritis (26,712) as for gout (8,485) in 1993, by 2011, there were nearly twice as many admissions for gout (20,949) as for rheumatoid arthritis (11,015). Likewise, hospitalization rates for gout rose from 4.5 to 9 per 100,000 adults, while rheumatoid arthritis admissions fell by about two-thirds, from 14 to 5 per 100,000 adults. For the entire study period, hospital admissions for gout totaled 254,982, compared with 323,649 for rheumatoid arthritis, Dr. Lim added.

The investigators also documented a steady drop in admissions for total knee replacement, total hip replacement, and other major joint surgeries among rheumatoid arthritis patients, mirroring the results of recent multicenter studies in California (Ann Rheum Dis. 2009 Jul 5. doi: 10.1136/ard.2009.112474), the United Kingdom (Rheumatology [Oxford]. 2015 Apr;54[4]:666-71), and Germany (Ann Rheum Dis. 2015;74:738-45), Dr. Lim said. “This finding contrasts with the overall dramatic increase in these surgeries in the general United States population in recent years,” he added.

Inflation-adjusted hospital costs for gout and rheumatoid arthritis also converged during the study period, and by 2011, costs for gout actually exceeded those for rheumatoid arthritis, Dr. Lim said.

Overall, the findings reflect stark differences in care for gout and rheumatoid arthritis in the United States, he added. “New and potent drugs, effective combination regimens, and management strategies are increasingly being adopted for rheumatoid arthritis, but care for gout remains suboptimal, even though its prevalence and incidence are increasing,” he said. “Although the vast majority of gout patients are indicated for urate-lowering therapy, only a small proportion retrieve treatment, and the level of uric acid is not even measured in the vast majority of patients.”

Surveys also indicate that patients with gout often do not receive clear explanations about their disease, which may explain why as few as 10% follow treatment recommendations, according to Dr. Lim. He pointed to a hospital-based, retrospective cohort study reported at last year’s ACR annual meeting in which 89% of hospitalizations for gout were considered preventable. “These data support the need to improve gout prevention and care,” he said.

Dr. Lim had no disclosures. Dr. Hyon Choi, the senior author, reported having served on advisory boards for Takeda and AstraZeneca.

SAN FRANCISCO – Hospitalization rates for gout doubled between 1993 and 2011, while those for rheumatoid arthritis fell by 67%, Dr. Sian Yik Lim reported at the annual meeting of the American College of Rheumatology.

The trends reveal marked progress in the treatment of rheumatoid arthritis, but “also highlight a critical need to improve gout care” and to implement measures to combat its rising prevalence, said Dr. Lim, a research fellow in medicine at Massachusetts General Hospital, Boston.

The study is “a very nice piece of work,” added Dr. James Galloway, who helped moderate the session at the meeting and is a lecturer in rheumatology at King’s College Hospital in London. “It makes us wonder whether we should spend more time teaching our primary care physician colleagues more about gout than rheumatoid arthritis.”

©Kimberly Pack/Thinkstock.com

Gout and rheumatoid arthritis are the two most common inflammatory joint diseases, but few longitudinal studies have examined trends in related hospital admissions or costs, Dr. Lim said. Therefore, he and his associates extracted primary hospital discharge ICD-9 diagnosis codes from the National Inpatient Sample and also studied primary procedure codes for total knee replacement, total hip replacement, and other major joint surgeries for 1993 through 2011. In addition, they merged these with cost data from the Healthcare Cost and Utilization Project for 2001 to 2011.

Hospitalizations for gout and rheumatoid arthritis “crisscrossed” during the study period, Dr. Lim said. While there were more than three times as many hospitalizations for rheumatoid arthritis (26,712) as for gout (8,485) in 1993, by 2011, there were nearly twice as many admissions for gout (20,949) as for rheumatoid arthritis (11,015). Likewise, hospitalization rates for gout rose from 4.5 to 9 per 100,000 adults, while rheumatoid arthritis admissions fell by about two-thirds, from 14 to 5 per 100,000 adults. For the entire study period, hospital admissions for gout totaled 254,982, compared with 323,649 for rheumatoid arthritis, Dr. Lim added.

The investigators also documented a steady drop in admissions for total knee replacement, total hip replacement, and other major joint surgeries among rheumatoid arthritis patients, mirroring the results of recent multicenter studies in California (Ann Rheum Dis. 2009 Jul 5. doi: 10.1136/ard.2009.112474), the United Kingdom (Rheumatology [Oxford]. 2015 Apr;54[4]:666-71), and Germany (Ann Rheum Dis. 2015;74:738-45), Dr. Lim said. “This finding contrasts with the overall dramatic increase in these surgeries in the general United States population in recent years,” he added.

Inflation-adjusted hospital costs for gout and rheumatoid arthritis also converged during the study period, and by 2011, costs for gout actually exceeded those for rheumatoid arthritis, Dr. Lim said.

Overall, the findings reflect stark differences in care for gout and rheumatoid arthritis in the United States, he added. “New and potent drugs, effective combination regimens, and management strategies are increasingly being adopted for rheumatoid arthritis, but care for gout remains suboptimal, even though its prevalence and incidence are increasing,” he said. “Although the vast majority of gout patients are indicated for urate-lowering therapy, only a small proportion retrieve treatment, and the level of uric acid is not even measured in the vast majority of patients.”

Surveys also indicate that patients with gout often do not receive clear explanations about their disease, which may explain why as few as 10% follow treatment recommendations, according to Dr. Lim. He pointed to a hospital-based, retrospective cohort study reported at last year’s ACR annual meeting in which 89% of hospitalizations for gout were considered preventable. “These data support the need to improve gout prevention and care,” he said.

Dr. Lim had no disclosures. Dr. Hyon Choi, the senior author, reported having served on advisory boards for Takeda and AstraZeneca.

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Key clinical point: Hospitalizations and costs for gout in the United States have surpassed those for rheumatoid arthritis, reflecting stark differences in the state of care for these diseases.

Major finding: Between 1993 and 2011, hospitalizations for gout rose from 4.5 to 9 per 100,000 adults, while rheumatoid arthritis admissions fell from 14 to 5 per 100,000 adults.

Data source: Analysis of primary discharge diagnoses from the National Inpatient Sample and cost data from the Healthcare Cost and Utilization Project.

Disclosures: Dr. Lim had no disclosures. Dr. Hyon Choi, the senior author, reported having served on advisory boards for Takeda and AstraZeneca.

Reports of my departure are premature

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Busy day at the office. Five different people asked when I plan to retire.

Dennis was first. I last saw him a year ago, as I’d been doing annually for 25 years. A few months later, he asked to have his records sent to his home. There was no obvious reason. Now he was back.

“I had an eventful year, medically,” he said. “You know, that biopsy you did on my nose was precancerous.”

I did know that. I had called him with the results. It was an actinic keratosis. I’d asked him to come back in a few months for me to recheck the area.

“I went to see another doctor,” he said. “He gave me a cream that made my skin turn red. I think it worked.”

It must have. After all, the keratosis had already been removed.

“But I didn’t like his office,” said Dennis, “so I decided to come back to you.”

Touching, I thought. “Nice to see you,” I said.

“I wanted a younger doctor,” said Dennis. “Someone who would be around for a while.”

“Well, I’m not planning to retire just yet.”

“Everyone retires eventually,” said Dennis.

“Yes,” I agreed. “I guess they do. See you next year.” Perhaps.

Well, that felt pretty good. Then I went in to see Phil.

“Good morning,” he said. “Are you thinking about retiring?”

“Not really,” I said.

“How old are you?” asked Phil.

“68,” I said.

Phil took a long look at me. “You look good,” he decided.

You don’t have to sound so surprised, I thought.

An hour later I saw Emma.

“I see you haven’t retired yet,” she said.

“No,” I replied. “It seems I haven’t. Would you like me to?”

“Oh, no!” said Emma. “I was just wondering. A lot of my doctors have been retiring.”

There it was. Fear of abandonment. Who will be there for me? I wanted to hold Emma’s hand and assure her that when the time came, someone would indeed be there for her when I wasn’t. But I didn’t. Like grown children, patients have to find out things like that for themselves.

A little later Mabel came by. Her rash was worrying her. “I saw a couple of doctors about it, but they didn’t seem to know what it was,” she said.

“It’s eczema,” I told her. “This is what I suggest you do.” I made some suggestions.

“I was here once before,” she said, “in the 80s. Then, when I couldn’t figure out what this rash I have was, I remembered your name. ‘No,’ I thought to myself. ‘He couldn’t possibly still be practicing.’ And then I found out that you were!”

Well, there you go.

This kind of thing can give you a complex. If so many people are surprised that you’re around, maybe you shouldn’t be. But the best was yet to come.

The last patient of the day was Jenna.

I introduced myself. “How did you get my name?” I asked. Nowadays, the most common answer I get goes something like, “I Googled you. I recognized your address and you got decent reviews.”

But Jenna answered, “My sister came here 10 years ago. She used to be a patient of Dr. Alvin Sherwin.”

“I took over Dr. Sherwin’s practice when he moved to Florida,” I told her. “That was in 1981, so it’s closer to 35 years ago, not 10.”

“My goodness,” she said. “That explains what my sister said.”

“What did your sister say?”

“Well, my mother found your name on a piece of paper. My mother likes to hold onto things.”

“I’ll say she does,” I said.

“My mother said, ‘Why don’t you call this guy Rockoff? He took care of your sister. He’s very good.’ So I looked you up and found your office.

“Anyway,” Jenna went on, “when I told my sister that I found you, she said, ‘Yes, I remember seeing him. You mean he’s still around? After all these years, I figured he was probably dead.’ ”

“Nope,” I said. “Not yet.”

Dr. Rockoff practices dermatology in Brookline, Mass., and is a longtime contributor to Dermatology News. He serves on the clinical faculty at Tufts University, Boston, and has taught senior medical students and other trainees for 30 years.

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Busy day at the office. Five different people asked when I plan to retire.

Dennis was first. I last saw him a year ago, as I’d been doing annually for 25 years. A few months later, he asked to have his records sent to his home. There was no obvious reason. Now he was back.

“I had an eventful year, medically,” he said. “You know, that biopsy you did on my nose was precancerous.”

I did know that. I had called him with the results. It was an actinic keratosis. I’d asked him to come back in a few months for me to recheck the area.

“I went to see another doctor,” he said. “He gave me a cream that made my skin turn red. I think it worked.”

It must have. After all, the keratosis had already been removed.

“But I didn’t like his office,” said Dennis, “so I decided to come back to you.”

Touching, I thought. “Nice to see you,” I said.

“I wanted a younger doctor,” said Dennis. “Someone who would be around for a while.”

“Well, I’m not planning to retire just yet.”

“Everyone retires eventually,” said Dennis.

“Yes,” I agreed. “I guess they do. See you next year.” Perhaps.

Well, that felt pretty good. Then I went in to see Phil.

“Good morning,” he said. “Are you thinking about retiring?”

“Not really,” I said.

“How old are you?” asked Phil.

“68,” I said.

Phil took a long look at me. “You look good,” he decided.

You don’t have to sound so surprised, I thought.

An hour later I saw Emma.

“I see you haven’t retired yet,” she said.

“No,” I replied. “It seems I haven’t. Would you like me to?”

“Oh, no!” said Emma. “I was just wondering. A lot of my doctors have been retiring.”

There it was. Fear of abandonment. Who will be there for me? I wanted to hold Emma’s hand and assure her that when the time came, someone would indeed be there for her when I wasn’t. But I didn’t. Like grown children, patients have to find out things like that for themselves.

A little later Mabel came by. Her rash was worrying her. “I saw a couple of doctors about it, but they didn’t seem to know what it was,” she said.

“It’s eczema,” I told her. “This is what I suggest you do.” I made some suggestions.

“I was here once before,” she said, “in the 80s. Then, when I couldn’t figure out what this rash I have was, I remembered your name. ‘No,’ I thought to myself. ‘He couldn’t possibly still be practicing.’ And then I found out that you were!”

Well, there you go.

This kind of thing can give you a complex. If so many people are surprised that you’re around, maybe you shouldn’t be. But the best was yet to come.

The last patient of the day was Jenna.

I introduced myself. “How did you get my name?” I asked. Nowadays, the most common answer I get goes something like, “I Googled you. I recognized your address and you got decent reviews.”

But Jenna answered, “My sister came here 10 years ago. She used to be a patient of Dr. Alvin Sherwin.”

“I took over Dr. Sherwin’s practice when he moved to Florida,” I told her. “That was in 1981, so it’s closer to 35 years ago, not 10.”

“My goodness,” she said. “That explains what my sister said.”

“What did your sister say?”

“Well, my mother found your name on a piece of paper. My mother likes to hold onto things.”

“I’ll say she does,” I said.

“My mother said, ‘Why don’t you call this guy Rockoff? He took care of your sister. He’s very good.’ So I looked you up and found your office.

“Anyway,” Jenna went on, “when I told my sister that I found you, she said, ‘Yes, I remember seeing him. You mean he’s still around? After all these years, I figured he was probably dead.’ ”

“Nope,” I said. “Not yet.”

Dr. Rockoff practices dermatology in Brookline, Mass., and is a longtime contributor to Dermatology News. He serves on the clinical faculty at Tufts University, Boston, and has taught senior medical students and other trainees for 30 years.

Busy day at the office. Five different people asked when I plan to retire.

Dennis was first. I last saw him a year ago, as I’d been doing annually for 25 years. A few months later, he asked to have his records sent to his home. There was no obvious reason. Now he was back.

“I had an eventful year, medically,” he said. “You know, that biopsy you did on my nose was precancerous.”

I did know that. I had called him with the results. It was an actinic keratosis. I’d asked him to come back in a few months for me to recheck the area.

“I went to see another doctor,” he said. “He gave me a cream that made my skin turn red. I think it worked.”

It must have. After all, the keratosis had already been removed.

“But I didn’t like his office,” said Dennis, “so I decided to come back to you.”

Touching, I thought. “Nice to see you,” I said.

“I wanted a younger doctor,” said Dennis. “Someone who would be around for a while.”

“Well, I’m not planning to retire just yet.”

“Everyone retires eventually,” said Dennis.

“Yes,” I agreed. “I guess they do. See you next year.” Perhaps.

Well, that felt pretty good. Then I went in to see Phil.

“Good morning,” he said. “Are you thinking about retiring?”

“Not really,” I said.

“How old are you?” asked Phil.

“68,” I said.

Phil took a long look at me. “You look good,” he decided.

You don’t have to sound so surprised, I thought.

An hour later I saw Emma.

“I see you haven’t retired yet,” she said.

“No,” I replied. “It seems I haven’t. Would you like me to?”

“Oh, no!” said Emma. “I was just wondering. A lot of my doctors have been retiring.”

There it was. Fear of abandonment. Who will be there for me? I wanted to hold Emma’s hand and assure her that when the time came, someone would indeed be there for her when I wasn’t. But I didn’t. Like grown children, patients have to find out things like that for themselves.

A little later Mabel came by. Her rash was worrying her. “I saw a couple of doctors about it, but they didn’t seem to know what it was,” she said.

“It’s eczema,” I told her. “This is what I suggest you do.” I made some suggestions.

“I was here once before,” she said, “in the 80s. Then, when I couldn’t figure out what this rash I have was, I remembered your name. ‘No,’ I thought to myself. ‘He couldn’t possibly still be practicing.’ And then I found out that you were!”

Well, there you go.

This kind of thing can give you a complex. If so many people are surprised that you’re around, maybe you shouldn’t be. But the best was yet to come.

The last patient of the day was Jenna.

I introduced myself. “How did you get my name?” I asked. Nowadays, the most common answer I get goes something like, “I Googled you. I recognized your address and you got decent reviews.”

But Jenna answered, “My sister came here 10 years ago. She used to be a patient of Dr. Alvin Sherwin.”

“I took over Dr. Sherwin’s practice when he moved to Florida,” I told her. “That was in 1981, so it’s closer to 35 years ago, not 10.”

“My goodness,” she said. “That explains what my sister said.”

“What did your sister say?”

“Well, my mother found your name on a piece of paper. My mother likes to hold onto things.”

“I’ll say she does,” I said.

“My mother said, ‘Why don’t you call this guy Rockoff? He took care of your sister. He’s very good.’ So I looked you up and found your office.

“Anyway,” Jenna went on, “when I told my sister that I found you, she said, ‘Yes, I remember seeing him. You mean he’s still around? After all these years, I figured he was probably dead.’ ”

“Nope,” I said. “Not yet.”

Dr. Rockoff practices dermatology in Brookline, Mass., and is a longtime contributor to Dermatology News. He serves on the clinical faculty at Tufts University, Boston, and has taught senior medical students and other trainees for 30 years.

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New ACC/AHA/HRS Guideline for Management of SVT

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New ACC/AHA/HRS Guideline for Management of SVT

NEW YORK - Catheter ablation is favored for the management of most forms of supraventricular tachycardia (SVT) in adults, according to revised guidelines from the American College of Cardiology/American Heart Association/Heart Rhythm Society (ACC/AHA/HRS).

SVT affects 2.25 in 1000 individuals in the general population, with about 89,000 new cases of paroxysmal SVT (PSVT) per year. Women are twice as likely as men and individuals older than 65 are more than five times as likely as younger people to develop PSVT.

To provide a contemporary guideline for managing adults with all types of SVT except atrial fibrillation, ACC/AHA/HRS have now updated their 2003 guidelines.

Included are recommendations for managing sinus tachyarrhythmias, nonsinus focal atrial tachycardia and multifocal atrial tachycardia (MAT), atrioventricular nodal reentrant tachycardia (AVNRT), manifest and concealed accessory pathways, atrial flutter, and junctional tachycardia.

"Despite a 12-year gap in the update for these guidelines, there have been very few advances in antiarrhythmic drug therapy to offer patients with SVT," Dr. Gregory F. Michaud, director of the Center for Advanced Management of Atrial Fibrillation at Brigham and Women's Hospital in Boston, said by email.

"Catheter ablation has taken a stronger foothold in the chronic treatment of SVT and as such many physicians and patients are opting for invasive therapy earlier in the course of therapy," said Dr. Michaud, who wasn't involved in the guidelines.

The guidelines recommend vagal maneuvers, various drugs, and/or cardioversion as acute treatments, depending on the specific cause of SVT.

For most forms of symptomatic SVT, including those of unknown mechanism, the guidelines recommend electrophysiological (EP) studies and catheter ablation as definitive treatment for patients willing to undergo them, especially if medical therapy is ineffective.

Cardiac mapping is performed during EP studies to identify the site of origin of the arrhythmia or areas of critical conduction to allow targeting of ablation.

"One exception is inappropriate sinus tachycardia (IST) for which a more effective drug, ivabradine, is now available in the United States," Dr. Michaud said. "Catheter ablation is generally ineffective for IST patients."

Besides evaluation and treatment of possible reversible causes of IST, the guidelines recommend ivabradine, beta blockers, or their combination.

"SVT is generally not a life-threatening condition and treatment is based on eliminating symptoms and improving patient quality of life," Dr. Michaud explained. "However, physicians should be aware of three conditions associated with SVT that may be serious. First, sudden death is associated with the WPW (Wolff-Parkinson-White) syndrome and these patients, even if asymptomatic, should be referred to a cardiac electrophysiologist to consider management options."

He continued, "Second, SVT can cause cardiomyopathy and heart failure when incessant, even if the patient is asymptomatic. These patients should also be referred to a cardiac electrophysiologist to consider definitive therapy.

Third, patients with atrial flutter should be considered for oral anticoagulation to prevent stroke using the CHADS-Vasc risk scoring system, just as you would for patients with atrial fibrillation."

Dr. Michaud added, "Putting aside cost as an issue, there is significant regional variability in the accessibility of electrophysiologists or cardiologists with arrhythmia expertise. In my area, for instance, electrophysiologists are plentiful, and patients with SVT are often sent to us directly for further evaluation and treatment. Furthermore, training in arrhythmia management has become the purview of clinical cardiac electrophysiology, and many recently trained cardiologists are not as comfortable as their predecessors in managing patients with SVT."

The full report appears in the September 23 Journal of the American College of Cardiology online and was copublished in Circulation and Heart Rhythm.

Dr. Richard L. Page and Dr. Jose A. Joglar, chair and vice chair of the writing committee, did not respond to a request for comments.

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NEW YORK - Catheter ablation is favored for the management of most forms of supraventricular tachycardia (SVT) in adults, according to revised guidelines from the American College of Cardiology/American Heart Association/Heart Rhythm Society (ACC/AHA/HRS).

SVT affects 2.25 in 1000 individuals in the general population, with about 89,000 new cases of paroxysmal SVT (PSVT) per year. Women are twice as likely as men and individuals older than 65 are more than five times as likely as younger people to develop PSVT.

To provide a contemporary guideline for managing adults with all types of SVT except atrial fibrillation, ACC/AHA/HRS have now updated their 2003 guidelines.

Included are recommendations for managing sinus tachyarrhythmias, nonsinus focal atrial tachycardia and multifocal atrial tachycardia (MAT), atrioventricular nodal reentrant tachycardia (AVNRT), manifest and concealed accessory pathways, atrial flutter, and junctional tachycardia.

"Despite a 12-year gap in the update for these guidelines, there have been very few advances in antiarrhythmic drug therapy to offer patients with SVT," Dr. Gregory F. Michaud, director of the Center for Advanced Management of Atrial Fibrillation at Brigham and Women's Hospital in Boston, said by email.

"Catheter ablation has taken a stronger foothold in the chronic treatment of SVT and as such many physicians and patients are opting for invasive therapy earlier in the course of therapy," said Dr. Michaud, who wasn't involved in the guidelines.

The guidelines recommend vagal maneuvers, various drugs, and/or cardioversion as acute treatments, depending on the specific cause of SVT.

For most forms of symptomatic SVT, including those of unknown mechanism, the guidelines recommend electrophysiological (EP) studies and catheter ablation as definitive treatment for patients willing to undergo them, especially if medical therapy is ineffective.

Cardiac mapping is performed during EP studies to identify the site of origin of the arrhythmia or areas of critical conduction to allow targeting of ablation.

"One exception is inappropriate sinus tachycardia (IST) for which a more effective drug, ivabradine, is now available in the United States," Dr. Michaud said. "Catheter ablation is generally ineffective for IST patients."

Besides evaluation and treatment of possible reversible causes of IST, the guidelines recommend ivabradine, beta blockers, or their combination.

"SVT is generally not a life-threatening condition and treatment is based on eliminating symptoms and improving patient quality of life," Dr. Michaud explained. "However, physicians should be aware of three conditions associated with SVT that may be serious. First, sudden death is associated with the WPW (Wolff-Parkinson-White) syndrome and these patients, even if asymptomatic, should be referred to a cardiac electrophysiologist to consider management options."

He continued, "Second, SVT can cause cardiomyopathy and heart failure when incessant, even if the patient is asymptomatic. These patients should also be referred to a cardiac electrophysiologist to consider definitive therapy.

Third, patients with atrial flutter should be considered for oral anticoagulation to prevent stroke using the CHADS-Vasc risk scoring system, just as you would for patients with atrial fibrillation."

Dr. Michaud added, "Putting aside cost as an issue, there is significant regional variability in the accessibility of electrophysiologists or cardiologists with arrhythmia expertise. In my area, for instance, electrophysiologists are plentiful, and patients with SVT are often sent to us directly for further evaluation and treatment. Furthermore, training in arrhythmia management has become the purview of clinical cardiac electrophysiology, and many recently trained cardiologists are not as comfortable as their predecessors in managing patients with SVT."

The full report appears in the September 23 Journal of the American College of Cardiology online and was copublished in Circulation and Heart Rhythm.

Dr. Richard L. Page and Dr. Jose A. Joglar, chair and vice chair of the writing committee, did not respond to a request for comments.

NEW YORK - Catheter ablation is favored for the management of most forms of supraventricular tachycardia (SVT) in adults, according to revised guidelines from the American College of Cardiology/American Heart Association/Heart Rhythm Society (ACC/AHA/HRS).

SVT affects 2.25 in 1000 individuals in the general population, with about 89,000 new cases of paroxysmal SVT (PSVT) per year. Women are twice as likely as men and individuals older than 65 are more than five times as likely as younger people to develop PSVT.

To provide a contemporary guideline for managing adults with all types of SVT except atrial fibrillation, ACC/AHA/HRS have now updated their 2003 guidelines.

Included are recommendations for managing sinus tachyarrhythmias, nonsinus focal atrial tachycardia and multifocal atrial tachycardia (MAT), atrioventricular nodal reentrant tachycardia (AVNRT), manifest and concealed accessory pathways, atrial flutter, and junctional tachycardia.

"Despite a 12-year gap in the update for these guidelines, there have been very few advances in antiarrhythmic drug therapy to offer patients with SVT," Dr. Gregory F. Michaud, director of the Center for Advanced Management of Atrial Fibrillation at Brigham and Women's Hospital in Boston, said by email.

"Catheter ablation has taken a stronger foothold in the chronic treatment of SVT and as such many physicians and patients are opting for invasive therapy earlier in the course of therapy," said Dr. Michaud, who wasn't involved in the guidelines.

The guidelines recommend vagal maneuvers, various drugs, and/or cardioversion as acute treatments, depending on the specific cause of SVT.

For most forms of symptomatic SVT, including those of unknown mechanism, the guidelines recommend electrophysiological (EP) studies and catheter ablation as definitive treatment for patients willing to undergo them, especially if medical therapy is ineffective.

Cardiac mapping is performed during EP studies to identify the site of origin of the arrhythmia or areas of critical conduction to allow targeting of ablation.

"One exception is inappropriate sinus tachycardia (IST) for which a more effective drug, ivabradine, is now available in the United States," Dr. Michaud said. "Catheter ablation is generally ineffective for IST patients."

Besides evaluation and treatment of possible reversible causes of IST, the guidelines recommend ivabradine, beta blockers, or their combination.

"SVT is generally not a life-threatening condition and treatment is based on eliminating symptoms and improving patient quality of life," Dr. Michaud explained. "However, physicians should be aware of three conditions associated with SVT that may be serious. First, sudden death is associated with the WPW (Wolff-Parkinson-White) syndrome and these patients, even if asymptomatic, should be referred to a cardiac electrophysiologist to consider management options."

He continued, "Second, SVT can cause cardiomyopathy and heart failure when incessant, even if the patient is asymptomatic. These patients should also be referred to a cardiac electrophysiologist to consider definitive therapy.

Third, patients with atrial flutter should be considered for oral anticoagulation to prevent stroke using the CHADS-Vasc risk scoring system, just as you would for patients with atrial fibrillation."

Dr. Michaud added, "Putting aside cost as an issue, there is significant regional variability in the accessibility of electrophysiologists or cardiologists with arrhythmia expertise. In my area, for instance, electrophysiologists are plentiful, and patients with SVT are often sent to us directly for further evaluation and treatment. Furthermore, training in arrhythmia management has become the purview of clinical cardiac electrophysiology, and many recently trained cardiologists are not as comfortable as their predecessors in managing patients with SVT."

The full report appears in the September 23 Journal of the American College of Cardiology online and was copublished in Circulation and Heart Rhythm.

Dr. Richard L. Page and Dr. Jose A. Joglar, chair and vice chair of the writing committee, did not respond to a request for comments.

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