In the dawn of the vaccines Gardasil and Cervarix, pediatricians, family physicians, and ob.gyns. are faced with the daunting task of educating parents about the sexually transmitted infection human papillomavirus.

We can all relate to the moment the words leave our mouths, and the parents are already refusing it because they are sure their children will never engage in such activities. Or they have been inundated with negative media reports that there are many side effects, and that the body will clear the human papillomavirus (HPV) infection on its own. It is understandable that there would be some hesitation to consent to a three-dose vaccine for a virus that is passed sexually for a child who most recently was more interested in dolls than the opposite sex. As well, many pediatricians are on the fence as to how important it is to give this vaccine to the 10- to 16-year-olds, so they shy away from detailed explanations, and the vaccine is declined.

Well, half of all oropharyngeal cancers are caused by HPV (Oral Oncol. 2011;47:1048-54), and the incidence of oropharyngeal cancers caused by HPV has increased from 16% in 1984-1989 to 72% in .2000-2004 (J. Clin. Oncol. 2011;29:4294-301).

Another CDC report on results of the 2006-2010 National Survey of Family Growth indicated that although the rates of vaginal intercourse were declining among teens, the rates of oral sex were escalating. In the survey of more than 6,000 teens aged 15-19 years, 41% of females admitted to performing oral sex, as did 35% of males. That number increased to more than 80% in both men and women when 20- to 26-year-olds were surveyed. (Natl. Health Stat. Report 2012;56:1-16).

The reason put forth for the increase in oral sex was that teens deemed it a "safer" way to have sex, and some even felt that it is not a form of sex and that they maintain their virginity as long as they don’t engage in vaginal intercourse. Many studies even point out that teens deem oral sex as a casual interaction and term it the new "goodnight kiss."

With this reality, as pediatricians and family physicians, we need to get very comfortable with this vaccine and be aggressive about educating families about the risk not only of cervical cancer, but vaginal, vulvar, and penile cancers, and most importantly the oral cancers. The time from infection to presentation of a tumor is usually about 10 years.

Although there are more than 100 strains of HPV and our bodies can clear most of them in 1-2 years, HPV 16/18 has been shown to be oncogenic and much harder to treat in the oropharyngeal area when compared with the cervical area. It also has been noted that the survival rate is better and there is less metastasis with HPV-associated cancers than non–HPV-associated cancers.

Current studies support that the HPV vaccines are decreasing the incidence of HPV infections (J. Inf. Dis. 2013;208:385-93). Awareness and education are key to eradication of this virus, and prevention starts in our offices.

Dr. Pearce is a pediatrician in Frankfort, Ill. E-mail her at [email protected].

In the dawn of the vaccines Gardasil and Cervarix, pediatricians, family physicians, and ob.gyns. are faced with the daunting task of educating parents about the sexually transmitted infection human papillomavirus.

We can all relate to the moment the words leave our mouths, and the parents are already refusing it because they are sure their children will never engage in such activities. Or they have been inundated with negative media reports that there are many side effects, and that the body will clear the human papillomavirus (HPV) infection on its own. It is understandable that there would be some hesitation to consent to a three-dose vaccine for a virus that is passed sexually for a child who most recently was more interested in dolls than the opposite sex. As well, many pediatricians are on the fence as to how important it is to give this vaccine to the 10- to 16-year-olds, so they shy away from detailed explanations, and the vaccine is declined.

Well, half of all oropharyngeal cancers are caused by HPV (Oral Oncol. 2011;47:1048-54), and the incidence of oropharyngeal cancers caused by HPV has increased from 16% in 1984-1989 to 72% in .2000-2004 (J. Clin. Oncol. 2011;29:4294-301).

Another CDC report on results of the 2006-2010 National Survey of Family Growth indicated that although the rates of vaginal intercourse were declining among teens, the rates of oral sex were escalating. In the survey of more than 6,000 teens aged 15-19 years, 41% of females admitted to performing oral sex, as did 35% of males. That number increased to more than 80% in both men and women when 20- to 26-year-olds were surveyed. (Natl. Health Stat. Report 2012;56:1-16).

The reason put forth for the increase in oral sex was that teens deemed it a "safer" way to have sex, and some even felt that it is not a form of sex and that they maintain their virginity as long as they don’t engage in vaginal intercourse. Many studies even point out that teens deem oral sex as a casual interaction and term it the new "goodnight kiss."

With this reality, as pediatricians and family physicians, we need to get very comfortable with this vaccine and be aggressive about educating families about the risk not only of cervical cancer, but vaginal, vulvar, and penile cancers, and most importantly the oral cancers. The time from infection to presentation of a tumor is usually about 10 years.

Although there are more than 100 strains of HPV and our bodies can clear most of them in 1-2 years, HPV 16/18 has been shown to be oncogenic and much harder to treat in the oropharyngeal area when compared with the cervical area. It also has been noted that the survival rate is better and there is less metastasis with HPV-associated cancers than non–HPV-associated cancers.

Current studies support that the HPV vaccines are decreasing the incidence of HPV infections (J. Inf. Dis. 2013;208:385-93). Awareness and education are key to eradication of this virus, and prevention starts in our offices.

Dr. Pearce is a pediatrician in Frankfort, Ill. E-mail her at [email protected].

In the dawn of the vaccines Gardasil and Cervarix, pediatricians, family physicians, and ob.gyns. are faced with the daunting task of educating parents about the sexually transmitted infection human papillomavirus.

We can all relate to the moment the words leave our mouths, and the parents are already refusing it because they are sure their children will never engage in such activities. Or they have been inundated with negative media reports that there are many side effects, and that the body will clear the human papillomavirus (HPV) infection on its own. It is understandable that there would be some hesitation to consent to a three-dose vaccine for a virus that is passed sexually for a child who most recently was more interested in dolls than the opposite sex. As well, many pediatricians are on the fence as to how important it is to give this vaccine to the 10- to 16-year-olds, so they shy away from detailed explanations, and the vaccine is declined.

Well, half of all oropharyngeal cancers are caused by HPV (Oral Oncol. 2011;47:1048-54), and the incidence of oropharyngeal cancers caused by HPV has increased from 16% in 1984-1989 to 72% in .2000-2004 (J. Clin. Oncol. 2011;29:4294-301).

Another CDC report on results of the 2006-2010 National Survey of Family Growth indicated that although the rates of vaginal intercourse were declining among teens, the rates of oral sex were escalating. In the survey of more than 6,000 teens aged 15-19 years, 41% of females admitted to performing oral sex, as did 35% of males. That number increased to more than 80% in both men and women when 20- to 26-year-olds were surveyed. (Natl. Health Stat. Report 2012;56:1-16).

The reason put forth for the increase in oral sex was that teens deemed it a "safer" way to have sex, and some even felt that it is not a form of sex and that they maintain their virginity as long as they don’t engage in vaginal intercourse. Many studies even point out that teens deem oral sex as a casual interaction and term it the new "goodnight kiss."

With this reality, as pediatricians and family physicians, we need to get very comfortable with this vaccine and be aggressive about educating families about the risk not only of cervical cancer, but vaginal, vulvar, and penile cancers, and most importantly the oral cancers. The time from infection to presentation of a tumor is usually about 10 years.

Although there are more than 100 strains of HPV and our bodies can clear most of them in 1-2 years, HPV 16/18 has been shown to be oncogenic and much harder to treat in the oropharyngeal area when compared with the cervical area. It also has been noted that the survival rate is better and there is less metastasis with HPV-associated cancers than non–HPV-associated cancers.

Current studies support that the HPV vaccines are decreasing the incidence of HPV infections (J. Inf. Dis. 2013;208:385-93). Awareness and education are key to eradication of this virus, and prevention starts in our offices.

Dr. Pearce is a pediatrician in Frankfort, Ill. E-mail her at [email protected].

A new study that found no association between increased levels of hospitalist or cardiologist care and improved 30-day outcomes in older patients with heart failure might mean a coordinated approach is best, says the report’s lead author.

“Associations Between Use of the Hospitalist Model and Quality of Care and Outcomes of Older Patients Hospitalized for Heart Failure,” published in JACC Heart Failure, analyzed data from a heart-failure registry that included 31,505 Medicare beneficiaries in 166 hospitals.

After multivariable adjustment, researchers found that a 10% increase in the use of hospitalists was not related to an improvement in 30-day readmission rates, but it was linked to a slight increase in mortality (risk ratio: 1.03; 95% confidence interval [CI]: 1.00 to 1.06) and a decrease in length of stay (0.09 days; 95% CI: 0.02 to 0.16).

Similar results for 30-day readmission rates were found when care was associated with a 10% increase in the use of cardiologists, prompting lead author and cardiologist Robb Kociol, MD, to suggest that perhaps a hybrid model using both HM and cardiologist specialists may improve outcomes.

"Comanagement, or commingling of hospitalist and cardiologist care, in these patients may improve at least adherence to measures we know are associated with improved quality of care," says Dr. Kociol, director of advanced-heart-failure and ventricular-assist devices at the CardioVascular Institute at Beth Israel Deaconess Medical Center in Boston.

The paper also reported that increased use of hospitalists in hospitals with high use of cardiologists was associated with improved defect-free adherence to a composite of heart failure performance measures (risk ratio: 1.03; 95% CI: 1.01 to 1.06). Dr. Kociol says further research is needed to tease out just how a hybrid model of hospitalist-cardiologist care would work.

"One model might be that all of these patients are cared for by hospitalists with automatic cardiology consultation," he adds. "Or maybe we find a way to risk-stratify which patients are under the hospitalist service and which patients are cared for by cardiologists. None of those questions are answered in this analysis, but the paper does suggest there may be something that needs to be studied further."

Visit our website for more information on hospitalists’ impact on patient outcomes.

A new study that found no association between increased levels of hospitalist or cardiologist care and improved 30-day outcomes in older patients with heart failure might mean a coordinated approach is best, says the report’s lead author.

“Associations Between Use of the Hospitalist Model and Quality of Care and Outcomes of Older Patients Hospitalized for Heart Failure,” published in JACC Heart Failure, analyzed data from a heart-failure registry that included 31,505 Medicare beneficiaries in 166 hospitals.

After multivariable adjustment, researchers found that a 10% increase in the use of hospitalists was not related to an improvement in 30-day readmission rates, but it was linked to a slight increase in mortality (risk ratio: 1.03; 95% confidence interval [CI]: 1.00 to 1.06) and a decrease in length of stay (0.09 days; 95% CI: 0.02 to 0.16).

Similar results for 30-day readmission rates were found when care was associated with a 10% increase in the use of cardiologists, prompting lead author and cardiologist Robb Kociol, MD, to suggest that perhaps a hybrid model using both HM and cardiologist specialists may improve outcomes.

"Comanagement, or commingling of hospitalist and cardiologist care, in these patients may improve at least adherence to measures we know are associated with improved quality of care," says Dr. Kociol, director of advanced-heart-failure and ventricular-assist devices at the CardioVascular Institute at Beth Israel Deaconess Medical Center in Boston.

The paper also reported that increased use of hospitalists in hospitals with high use of cardiologists was associated with improved defect-free adherence to a composite of heart failure performance measures (risk ratio: 1.03; 95% CI: 1.01 to 1.06). Dr. Kociol says further research is needed to tease out just how a hybrid model of hospitalist-cardiologist care would work.

"One model might be that all of these patients are cared for by hospitalists with automatic cardiology consultation," he adds. "Or maybe we find a way to risk-stratify which patients are under the hospitalist service and which patients are cared for by cardiologists. None of those questions are answered in this analysis, but the paper does suggest there may be something that needs to be studied further."

Visit our website for more information on hospitalists’ impact on patient outcomes.

A new study that found no association between increased levels of hospitalist or cardiologist care and improved 30-day outcomes in older patients with heart failure might mean a coordinated approach is best, says the report’s lead author.

“Associations Between Use of the Hospitalist Model and Quality of Care and Outcomes of Older Patients Hospitalized for Heart Failure,” published in JACC Heart Failure, analyzed data from a heart-failure registry that included 31,505 Medicare beneficiaries in 166 hospitals.

After multivariable adjustment, researchers found that a 10% increase in the use of hospitalists was not related to an improvement in 30-day readmission rates, but it was linked to a slight increase in mortality (risk ratio: 1.03; 95% confidence interval [CI]: 1.00 to 1.06) and a decrease in length of stay (0.09 days; 95% CI: 0.02 to 0.16).

Similar results for 30-day readmission rates were found when care was associated with a 10% increase in the use of cardiologists, prompting lead author and cardiologist Robb Kociol, MD, to suggest that perhaps a hybrid model using both HM and cardiologist specialists may improve outcomes.

"Comanagement, or commingling of hospitalist and cardiologist care, in these patients may improve at least adherence to measures we know are associated with improved quality of care," says Dr. Kociol, director of advanced-heart-failure and ventricular-assist devices at the CardioVascular Institute at Beth Israel Deaconess Medical Center in Boston.

The paper also reported that increased use of hospitalists in hospitals with high use of cardiologists was associated with improved defect-free adherence to a composite of heart failure performance measures (risk ratio: 1.03; 95% CI: 1.01 to 1.06). Dr. Kociol says further research is needed to tease out just how a hybrid model of hospitalist-cardiologist care would work.

"One model might be that all of these patients are cared for by hospitalists with automatic cardiology consultation," he adds. "Or maybe we find a way to risk-stratify which patients are under the hospitalist service and which patients are cared for by cardiologists. None of those questions are answered in this analysis, but the paper does suggest there may be something that needs to be studied further."

Visit our website for more information on hospitalists’ impact on patient outcomes.

Matthew Heinz, MD, a hospitalist from Tucson, Ariz., has been appointed director of provider outreach at the U.S. Department of Health and Human Services (HHS), a position the agency created specifically to educate the public on health-care policies.

A practicing hospitalist at Tucson Medical Center and a former Arizona state legislator, Dr. Heinz travels to Washington a couple of weekends a month to work directly with healthcare providers, community leaders, and LGBT groups to provide information about implementation of the Affordable Care Act (ACA), including its coverage options and the enrollment period that started Oct. 1. He then brings questions and concerns back to HHS Secretary Kathleen Sebelius directly.

"Serving as a resource for providers and the community is a great honor," Dr. Heinz says. "It is an exciting time to be part of the Department of Health and Human Services; so much is happening with healthcare due to the ACA."

As a hospitalist for seven years, he says he understands what it means to be uninsured in America and what it can do to families economically. "I see firsthand how profoundly the lack of health insurance affects my patients," he says. "We have to make implementing the Affordable Care Act a priority, as providers, to help these families and individuals get the medical care that they need.

"This kind of change [in policies] hasn't been attempted since Medicare in the 1970s," Dr. Heinz says of the ACA. "It is a unique time and place. I'm pleased and honored that I am able to serve in this way."

Visit our website for more information on how the Affordable Care Act will affect hospitalists.

Matthew Heinz, MD, a hospitalist from Tucson, Ariz., has been appointed director of provider outreach at the U.S. Department of Health and Human Services (HHS), a position the agency created specifically to educate the public on health-care policies.

A practicing hospitalist at Tucson Medical Center and a former Arizona state legislator, Dr. Heinz travels to Washington a couple of weekends a month to work directly with healthcare providers, community leaders, and LGBT groups to provide information about implementation of the Affordable Care Act (ACA), including its coverage options and the enrollment period that started Oct. 1. He then brings questions and concerns back to HHS Secretary Kathleen Sebelius directly.

"Serving as a resource for providers and the community is a great honor," Dr. Heinz says. "It is an exciting time to be part of the Department of Health and Human Services; so much is happening with healthcare due to the ACA."

As a hospitalist for seven years, he says he understands what it means to be uninsured in America and what it can do to families economically. "I see firsthand how profoundly the lack of health insurance affects my patients," he says. "We have to make implementing the Affordable Care Act a priority, as providers, to help these families and individuals get the medical care that they need.

"This kind of change [in policies] hasn't been attempted since Medicare in the 1970s," Dr. Heinz says of the ACA. "It is a unique time and place. I'm pleased and honored that I am able to serve in this way."

Visit our website for more information on how the Affordable Care Act will affect hospitalists.

Matthew Heinz, MD, a hospitalist from Tucson, Ariz., has been appointed director of provider outreach at the U.S. Department of Health and Human Services (HHS), a position the agency created specifically to educate the public on health-care policies.

A practicing hospitalist at Tucson Medical Center and a former Arizona state legislator, Dr. Heinz travels to Washington a couple of weekends a month to work directly with healthcare providers, community leaders, and LGBT groups to provide information about implementation of the Affordable Care Act (ACA), including its coverage options and the enrollment period that started Oct. 1. He then brings questions and concerns back to HHS Secretary Kathleen Sebelius directly.

"Serving as a resource for providers and the community is a great honor," Dr. Heinz says. "It is an exciting time to be part of the Department of Health and Human Services; so much is happening with healthcare due to the ACA."

As a hospitalist for seven years, he says he understands what it means to be uninsured in America and what it can do to families economically. "I see firsthand how profoundly the lack of health insurance affects my patients," he says. "We have to make implementing the Affordable Care Act a priority, as providers, to help these families and individuals get the medical care that they need.

"This kind of change [in policies] hasn't been attempted since Medicare in the 1970s," Dr. Heinz says of the ACA. "It is a unique time and place. I'm pleased and honored that I am able to serve in this way."

Visit our website for more information on how the Affordable Care Act will affect hospitalists.

Matthew Heinz, MD, a hospitalist from Tucson, Ariz., has been appointed director of provider outreach at the U.S. Department of Health and Human Services (HHS), a position the agency created specifically to educate the public on health-care policies.

A practicing hospitalist at Tucson Medical Center and a former Arizona state legislator, Dr. Heinz travels to Washington a couple of weekends a month to work directly with healthcare providers, community leaders, and LGBT groups to provide information about implementation of the Affordable Care Act (ACA), including its coverage options and the enrollment period that started Oct. 1. He then brings questions and concerns back to HHS Secretary Kathleen Sebelius directly.

"Serving as a resource for providers and the community is a great honor," Dr. Heinz says. "It is an exciting time to be part of the Department of Health and Human Services; so much is happening with healthcare due to the ACA."

As a hospitalist for seven years, he says he understands what it means to be uninsured in America and what it can do to families economically. "I see firsthand how profoundly the lack of health insurance affects my patients," he says. "We have to make implementing the Affordable Care Act a priority, as providers, to help these families and individuals get the medical care that they need.

"This kind of change [in policies] hasn't been attempted since Medicare in the 1970s," Dr. Heinz says of the ACA. "It is a unique time and place. I'm pleased and honored that I am able to serve in this way."

Visit our website for more information on how the Affordable Care Act will affect hospitalists.

Matthew Heinz, MD, a hospitalist from Tucson, Ariz., has been appointed director of provider outreach at the U.S. Department of Health and Human Services (HHS), a position the agency created specifically to educate the public on health-care policies.

A practicing hospitalist at Tucson Medical Center and a former Arizona state legislator, Dr. Heinz travels to Washington a couple of weekends a month to work directly with healthcare providers, community leaders, and LGBT groups to provide information about implementation of the Affordable Care Act (ACA), including its coverage options and the enrollment period that started Oct. 1. He then brings questions and concerns back to HHS Secretary Kathleen Sebelius directly.

"Serving as a resource for providers and the community is a great honor," Dr. Heinz says. "It is an exciting time to be part of the Department of Health and Human Services; so much is happening with healthcare due to the ACA."

As a hospitalist for seven years, he says he understands what it means to be uninsured in America and what it can do to families economically. "I see firsthand how profoundly the lack of health insurance affects my patients," he says. "We have to make implementing the Affordable Care Act a priority, as providers, to help these families and individuals get the medical care that they need.

"This kind of change [in policies] hasn't been attempted since Medicare in the 1970s," Dr. Heinz says of the ACA. "It is a unique time and place. I'm pleased and honored that I am able to serve in this way."

Visit our website for more information on how the Affordable Care Act will affect hospitalists.

Matthew Heinz, MD, a hospitalist from Tucson, Ariz., has been appointed director of provider outreach at the U.S. Department of Health and Human Services (HHS), a position the agency created specifically to educate the public on health-care policies.

A practicing hospitalist at Tucson Medical Center and a former Arizona state legislator, Dr. Heinz travels to Washington a couple of weekends a month to work directly with healthcare providers, community leaders, and LGBT groups to provide information about implementation of the Affordable Care Act (ACA), including its coverage options and the enrollment period that started Oct. 1. He then brings questions and concerns back to HHS Secretary Kathleen Sebelius directly.

"Serving as a resource for providers and the community is a great honor," Dr. Heinz says. "It is an exciting time to be part of the Department of Health and Human Services; so much is happening with healthcare due to the ACA."

As a hospitalist for seven years, he says he understands what it means to be uninsured in America and what it can do to families economically. "I see firsthand how profoundly the lack of health insurance affects my patients," he says. "We have to make implementing the Affordable Care Act a priority, as providers, to help these families and individuals get the medical care that they need.

"This kind of change [in policies] hasn't been attempted since Medicare in the 1970s," Dr. Heinz says of the ACA. "It is a unique time and place. I'm pleased and honored that I am able to serve in this way."

Visit our website for more information on how the Affordable Care Act will affect hospitalists.

ATLANTA – Intensity-modulated radiation therapy proved significantly better than conventional radiation for local control of soft-tissue sarcomas of the extremities, according to new study results, investigators reported at the annual meeting of the American Society for Radiation Oncology.

The 5-year local control rate with intensity-modulated radiation therapy (IMRT) was 92.4%, compared with 85% for external-beam radiation therapy (EBRT), said Dr. Kaled M. Alektiar, a radiation oncologist at Memorial Sloan-Kettering Cancer Center in New York.

The benefits of IMRT were seen despite a preponderance of higher risks in patients treated with IMRT. And, "the morbidity profile, especially for chronic lymphedema of grade 3 or higher, was significantly less," Dr. Alektiar said.

He and his coinvestigators looked at 320 patients who underwent definitive surgery and radiation therapy at Memorial Sloan-Kettering for primary, nonmetastatic soft-tissue sarcomas of the extremities. Of this group, 155 received EBRT with a conventional technique, usually three-dimensional conformal radiation, and 165 patients received IMRT.

Most of the tumors (74.7%) were in the lower extremity, 45.6% were at least 10 cm in diameter, 92.2% were in deep tissue, 82.5% were high grade, and 40% had close or positive surgical margins. The majority of patients (75.9%) received adjuvant chemotherapy.

There were significantly more patients with positive or close margins in the IMRT group than in the conventional EBRT group (47.9% vs. 31.6%; P = .003), and more patients treated with IMRT had high-grade histology tumors, although this difference had only borderline significance (86.7% vs. 78.1%; P =.055).

Additionally, significantly more patients in the IMRT group received preoperative radiation (21.2% vs. 3.2%; P less than .001). Otherwise, the groups were balanced in terms of demographics, tumor size, depth, and use of CT in treatment planning.

The median follow-up was 49.5 months (42 months for patients treated with IMRT, and 87 months for those treated with EBRT). The 5-year local recurrence rates were 7.6% for IMRT and 15% for conventional EBRT. The median time to local recurrence was 18 months in each group.

Eight patients required amputations for salvage, including three in the IMRT cohort and five in the conventional radiation cohort.

In multivariate analysis, three factors that were significantly prognostic for local failure were IMRT (hazard ratio, 0.46; P = .02), age less than 50 years (HR, 0.44; P = .04), and a tumor size of 10 cm or less in the longest dimension (HR, 0.53; P = .05).

Overall survival at 5 years was 69.1% for IMRT and 75.6% for EBRT, a difference that was not significant.

Rates of grade 3 or 4 acute toxicities, including infected and noninfected wound complications and radiation dermatitis, were similar between the groups. Patients treated with IMRT had significantly shorter treatment interruptions, at a mean of 0.8 days, compared with 2.2 days for patients treated with conventional EBRT. Chronic grade 3 or higher lymphedema did not occur in any patients treated with IMRT, compared with four patients treated with conventional EBRT (P = .053).

The study was supported by a grant from the Clinical and Translational Science Center at Weill Cornell Medical College, New York. Dr. Alektiar reported having no relevant financial disclosures.

ATLANTA – Intensity-modulated radiation therapy proved significantly better than conventional radiation for local control of soft-tissue sarcomas of the extremities, according to new study results, investigators reported at the annual meeting of the American Society for Radiation Oncology.

The 5-year local control rate with intensity-modulated radiation therapy (IMRT) was 92.4%, compared with 85% for external-beam radiation therapy (EBRT), said Dr. Kaled M. Alektiar, a radiation oncologist at Memorial Sloan-Kettering Cancer Center in New York.

The benefits of IMRT were seen despite a preponderance of higher risks in patients treated with IMRT. And, "the morbidity profile, especially for chronic lymphedema of grade 3 or higher, was significantly less," Dr. Alektiar said.

He and his coinvestigators looked at 320 patients who underwent definitive surgery and radiation therapy at Memorial Sloan-Kettering for primary, nonmetastatic soft-tissue sarcomas of the extremities. Of this group, 155 received EBRT with a conventional technique, usually three-dimensional conformal radiation, and 165 patients received IMRT.

Most of the tumors (74.7%) were in the lower extremity, 45.6% were at least 10 cm in diameter, 92.2% were in deep tissue, 82.5% were high grade, and 40% had close or positive surgical margins. The majority of patients (75.9%) received adjuvant chemotherapy.

There were significantly more patients with positive or close margins in the IMRT group than in the conventional EBRT group (47.9% vs. 31.6%; P = .003), and more patients treated with IMRT had high-grade histology tumors, although this difference had only borderline significance (86.7% vs. 78.1%; P =.055).

Additionally, significantly more patients in the IMRT group received preoperative radiation (21.2% vs. 3.2%; P less than .001). Otherwise, the groups were balanced in terms of demographics, tumor size, depth, and use of CT in treatment planning.

The median follow-up was 49.5 months (42 months for patients treated with IMRT, and 87 months for those treated with EBRT). The 5-year local recurrence rates were 7.6% for IMRT and 15% for conventional EBRT. The median time to local recurrence was 18 months in each group.

Eight patients required amputations for salvage, including three in the IMRT cohort and five in the conventional radiation cohort.

In multivariate analysis, three factors that were significantly prognostic for local failure were IMRT (hazard ratio, 0.46; P = .02), age less than 50 years (HR, 0.44; P = .04), and a tumor size of 10 cm or less in the longest dimension (HR, 0.53; P = .05).

Overall survival at 5 years was 69.1% for IMRT and 75.6% for EBRT, a difference that was not significant.

Rates of grade 3 or 4 acute toxicities, including infected and noninfected wound complications and radiation dermatitis, were similar between the groups. Patients treated with IMRT had significantly shorter treatment interruptions, at a mean of 0.8 days, compared with 2.2 days for patients treated with conventional EBRT. Chronic grade 3 or higher lymphedema did not occur in any patients treated with IMRT, compared with four patients treated with conventional EBRT (P = .053).

The study was supported by a grant from the Clinical and Translational Science Center at Weill Cornell Medical College, New York. Dr. Alektiar reported having no relevant financial disclosures.

ATLANTA – Intensity-modulated radiation therapy proved significantly better than conventional radiation for local control of soft-tissue sarcomas of the extremities, according to new study results, investigators reported at the annual meeting of the American Society for Radiation Oncology.

The 5-year local control rate with intensity-modulated radiation therapy (IMRT) was 92.4%, compared with 85% for external-beam radiation therapy (EBRT), said Dr. Kaled M. Alektiar, a radiation oncologist at Memorial Sloan-Kettering Cancer Center in New York.

The benefits of IMRT were seen despite a preponderance of higher risks in patients treated with IMRT. And, "the morbidity profile, especially for chronic lymphedema of grade 3 or higher, was significantly less," Dr. Alektiar said.

He and his coinvestigators looked at 320 patients who underwent definitive surgery and radiation therapy at Memorial Sloan-Kettering for primary, nonmetastatic soft-tissue sarcomas of the extremities. Of this group, 155 received EBRT with a conventional technique, usually three-dimensional conformal radiation, and 165 patients received IMRT.

Most of the tumors (74.7%) were in the lower extremity, 45.6% were at least 10 cm in diameter, 92.2% were in deep tissue, 82.5% were high grade, and 40% had close or positive surgical margins. The majority of patients (75.9%) received adjuvant chemotherapy.

There were significantly more patients with positive or close margins in the IMRT group than in the conventional EBRT group (47.9% vs. 31.6%; P = .003), and more patients treated with IMRT had high-grade histology tumors, although this difference had only borderline significance (86.7% vs. 78.1%; P =.055).

Additionally, significantly more patients in the IMRT group received preoperative radiation (21.2% vs. 3.2%; P less than .001). Otherwise, the groups were balanced in terms of demographics, tumor size, depth, and use of CT in treatment planning.

The median follow-up was 49.5 months (42 months for patients treated with IMRT, and 87 months for those treated with EBRT). The 5-year local recurrence rates were 7.6% for IMRT and 15% for conventional EBRT. The median time to local recurrence was 18 months in each group.

Eight patients required amputations for salvage, including three in the IMRT cohort and five in the conventional radiation cohort.

In multivariate analysis, three factors that were significantly prognostic for local failure were IMRT (hazard ratio, 0.46; P = .02), age less than 50 years (HR, 0.44; P = .04), and a tumor size of 10 cm or less in the longest dimension (HR, 0.53; P = .05).

Overall survival at 5 years was 69.1% for IMRT and 75.6% for EBRT, a difference that was not significant.

Rates of grade 3 or 4 acute toxicities, including infected and noninfected wound complications and radiation dermatitis, were similar between the groups. Patients treated with IMRT had significantly shorter treatment interruptions, at a mean of 0.8 days, compared with 2.2 days for patients treated with conventional EBRT. Chronic grade 3 or higher lymphedema did not occur in any patients treated with IMRT, compared with four patients treated with conventional EBRT (P = .053).

The study was supported by a grant from the Clinical and Translational Science Center at Weill Cornell Medical College, New York. Dr. Alektiar reported having no relevant financial disclosures.

Dr. Kavita Mariwalla, the 2013 ASDS annual meeting chair, provides a 3-minute summary of the hot topics discussed at the American Society of Dermatologic Surgery, held in Chicago. For more, visit http://www.skindandallergynews.com.

Dr. Kavita Mariwalla, the 2013 ASDS annual meeting chair, provides a 3-minute summary of the hot topics discussed at the American Society of Dermatologic Surgery, held in Chicago. For more, visit http://www.skindandallergynews.com.

Dr. Kavita Mariwalla, the 2013 ASDS annual meeting chair, provides a 3-minute summary of the hot topics discussed at the American Society of Dermatologic Surgery, held in Chicago. For more, visit http://www.skindandallergynews.com.

Six and a half years ago, my malpractice insurer made a payment to settle a case against a company I once ran in a neighboring state. Nine years before that, a physician who worked for me had lasered a tattoo on a woman’s ankle. She claimed it got infected and then scarred, but refused to be examined at that time, or later.

This case wound its way slowly through the system. I drove to the nearby state to plot strategy with the insurer’s attorney for dealing with the $50,000 claim. "I can’t understand why anyone would take a case this small," said the attorney.

When we got to the courthouse that January day, we saw why. The plaintiff – whom I had never met – was accompanied by a lawyer. He and my attorney met with the judge.

"Settle this case," she ordered.

And so we did, for $22,500. The plaintiff stipulated that I "did not act negligently in any respect."

As we exited the courtroom into the hall, the plaintiff approached me. "My tattoo isn’t gone yet," she said. "Would you be able to treat it?"

My attorney’s jaw dropped. Not mine, though. I had her put her ankle up on a bench to look at it. There was no scarring, just the hypopigmentation one sees after laser treatment in that area.

"You know," I told her. "I’m all the way in the next state. "The doctor here in town who treated you – the one who was going to testify against me today? He would be perfect."

We smiled at each other, shook hands, and I went home.

Fast forward to last week. A registered letter came to my office from a local electrical union. It contained a flyer that read:

Don’t be in the DARK about your doctor. XYZ hospital continues to allow doctors with recent malpractice payments to treat patients, WHY?

DR. ALAN S. ROCKOFF MADE A MALPRACTICE PAYMENT.

What kind of DOCTOR do you want treating you and your loved ones?

The accompanying letter explained that, "We intend to distribute [the leaflet] in the near future to anyone entering or leaving your medical building, as well as residents and businesses in the surrounding community. We will also be publicizing the content on DrRockoffexposed.com and through social media including Facebook and Twitter."

They added, "We strive for accuracy in all of our leaflets and websites." I was given 1 week to let them know if I found "anything untruthful or inaccurate," to "kindly let me know."

I thought the "kindly" was a nice touch.

The leaflet included a lot of nasty innuendoes about hospital XYZ, where I have staff privileges.

Bewildered, I contacted my malpractice insurer, who helpfully told me there was nothing I could do, and suggested I contact the hospital, at whom the campaign was clearly intended. I did so. The people at the hospital expressed sympathy and outrage about the union’s letter, and told me to ignore it.

An attorney affiliated with my malpractice insurer did some digging, and he sent me a link to an article showing that his union had used similar tactics against a hospital north of town 2 years ago. Their motive, it appears, is to be sure their union secures contracts for work at the hospitals in question.

In other words, friends, this is what is known in Mafia movies as a shakedown. "Nice medical staff you’ve got there," says the leaflet, in so many words. "Be a shame if anything happened to it."

As a kid, I used to watch Elliot Ness in "The Untouchables," but I never thought I would be personally involved in anything I saw there. But if you live long enough, you never know what you’ll experience. Anyhow, any publicity is good publicity, and DrRockoffexposed.com does spell my name right, even if it’s not nearly as fun to see as what one could imagine at something like www.TweetingCongressmanExposed.com.

For better or worse, the time when doctors sat in their offices, wrote notes on 3x5 cards, and collected cash payments they stowed in their desk drawers are long gone. In the Olympian corridors of power far above our heads, powerful forces that dictate our lives hurl thunderbolts at each other as they vie for money, power, and control. The trick is to stay out of their way and avoid becoming collateral damage.

Easy to say. Less easy to do.

Dr. Rockoff practices dermatology in Brookline, Mass. He is on the clinical faculty at Tufts University School of Medicine, Boston, and has taught senior medical students and other trainees for 30 years. Dr. Rockoff has contributed to the Under My Skin column in Skin & Allergy News since January 2002.

Six and a half years ago, my malpractice insurer made a payment to settle a case against a company I once ran in a neighboring state. Nine years before that, a physician who worked for me had lasered a tattoo on a woman’s ankle. She claimed it got infected and then scarred, but refused to be examined at that time, or later.

This case wound its way slowly through the system. I drove to the nearby state to plot strategy with the insurer’s attorney for dealing with the $50,000 claim. "I can’t understand why anyone would take a case this small," said the attorney.

When we got to the courthouse that January day, we saw why. The plaintiff – whom I had never met – was accompanied by a lawyer. He and my attorney met with the judge.

"Settle this case," she ordered.

And so we did, for $22,500. The plaintiff stipulated that I "did not act negligently in any respect."

As we exited the courtroom into the hall, the plaintiff approached me. "My tattoo isn’t gone yet," she said. "Would you be able to treat it?"

My attorney’s jaw dropped. Not mine, though. I had her put her ankle up on a bench to look at it. There was no scarring, just the hypopigmentation one sees after laser treatment in that area.

"You know," I told her. "I’m all the way in the next state. "The doctor here in town who treated you – the one who was going to testify against me today? He would be perfect."

We smiled at each other, shook hands, and I went home.

Fast forward to last week. A registered letter came to my office from a local electrical union. It contained a flyer that read:

Don’t be in the DARK about your doctor. XYZ hospital continues to allow doctors with recent malpractice payments to treat patients, WHY?

DR. ALAN S. ROCKOFF MADE A MALPRACTICE PAYMENT.

What kind of DOCTOR do you want treating you and your loved ones?

The accompanying letter explained that, "We intend to distribute [the leaflet] in the near future to anyone entering or leaving your medical building, as well as residents and businesses in the surrounding community. We will also be publicizing the content on DrRockoffexposed.com and through social media including Facebook and Twitter."

They added, "We strive for accuracy in all of our leaflets and websites." I was given 1 week to let them know if I found "anything untruthful or inaccurate," to "kindly let me know."

I thought the "kindly" was a nice touch.

The leaflet included a lot of nasty innuendoes about hospital XYZ, where I have staff privileges.

Bewildered, I contacted my malpractice insurer, who helpfully told me there was nothing I could do, and suggested I contact the hospital, at whom the campaign was clearly intended. I did so. The people at the hospital expressed sympathy and outrage about the union’s letter, and told me to ignore it.

An attorney affiliated with my malpractice insurer did some digging, and he sent me a link to an article showing that his union had used similar tactics against a hospital north of town 2 years ago. Their motive, it appears, is to be sure their union secures contracts for work at the hospitals in question.

In other words, friends, this is what is known in Mafia movies as a shakedown. "Nice medical staff you’ve got there," says the leaflet, in so many words. "Be a shame if anything happened to it."

As a kid, I used to watch Elliot Ness in "The Untouchables," but I never thought I would be personally involved in anything I saw there. But if you live long enough, you never know what you’ll experience. Anyhow, any publicity is good publicity, and DrRockoffexposed.com does spell my name right, even if it’s not nearly as fun to see as what one could imagine at something like www.TweetingCongressmanExposed.com.

For better or worse, the time when doctors sat in their offices, wrote notes on 3x5 cards, and collected cash payments they stowed in their desk drawers are long gone. In the Olympian corridors of power far above our heads, powerful forces that dictate our lives hurl thunderbolts at each other as they vie for money, power, and control. The trick is to stay out of their way and avoid becoming collateral damage.

Easy to say. Less easy to do.

Dr. Rockoff practices dermatology in Brookline, Mass. He is on the clinical faculty at Tufts University School of Medicine, Boston, and has taught senior medical students and other trainees for 30 years. Dr. Rockoff has contributed to the Under My Skin column in Skin & Allergy News since January 2002.

Six and a half years ago, my malpractice insurer made a payment to settle a case against a company I once ran in a neighboring state. Nine years before that, a physician who worked for me had lasered a tattoo on a woman’s ankle. She claimed it got infected and then scarred, but refused to be examined at that time, or later.

This case wound its way slowly through the system. I drove to the nearby state to plot strategy with the insurer’s attorney for dealing with the $50,000 claim. "I can’t understand why anyone would take a case this small," said the attorney.

When we got to the courthouse that January day, we saw why. The plaintiff – whom I had never met – was accompanied by a lawyer. He and my attorney met with the judge.

"Settle this case," she ordered.

And so we did, for $22,500. The plaintiff stipulated that I "did not act negligently in any respect."

As we exited the courtroom into the hall, the plaintiff approached me. "My tattoo isn’t gone yet," she said. "Would you be able to treat it?"

My attorney’s jaw dropped. Not mine, though. I had her put her ankle up on a bench to look at it. There was no scarring, just the hypopigmentation one sees after laser treatment in that area.

"You know," I told her. "I’m all the way in the next state. "The doctor here in town who treated you – the one who was going to testify against me today? He would be perfect."

We smiled at each other, shook hands, and I went home.

Fast forward to last week. A registered letter came to my office from a local electrical union. It contained a flyer that read:

Don’t be in the DARK about your doctor. XYZ hospital continues to allow doctors with recent malpractice payments to treat patients, WHY?

DR. ALAN S. ROCKOFF MADE A MALPRACTICE PAYMENT.

What kind of DOCTOR do you want treating you and your loved ones?

The accompanying letter explained that, "We intend to distribute [the leaflet] in the near future to anyone entering or leaving your medical building, as well as residents and businesses in the surrounding community. We will also be publicizing the content on DrRockoffexposed.com and through social media including Facebook and Twitter."

They added, "We strive for accuracy in all of our leaflets and websites." I was given 1 week to let them know if I found "anything untruthful or inaccurate," to "kindly let me know."

I thought the "kindly" was a nice touch.

The leaflet included a lot of nasty innuendoes about hospital XYZ, where I have staff privileges.

Bewildered, I contacted my malpractice insurer, who helpfully told me there was nothing I could do, and suggested I contact the hospital, at whom the campaign was clearly intended. I did so. The people at the hospital expressed sympathy and outrage about the union’s letter, and told me to ignore it.

An attorney affiliated with my malpractice insurer did some digging, and he sent me a link to an article showing that his union had used similar tactics against a hospital north of town 2 years ago. Their motive, it appears, is to be sure their union secures contracts for work at the hospitals in question.

In other words, friends, this is what is known in Mafia movies as a shakedown. "Nice medical staff you’ve got there," says the leaflet, in so many words. "Be a shame if anything happened to it."

As a kid, I used to watch Elliot Ness in "The Untouchables," but I never thought I would be personally involved in anything I saw there. But if you live long enough, you never know what you’ll experience. Anyhow, any publicity is good publicity, and DrRockoffexposed.com does spell my name right, even if it’s not nearly as fun to see as what one could imagine at something like www.TweetingCongressmanExposed.com.

For better or worse, the time when doctors sat in their offices, wrote notes on 3x5 cards, and collected cash payments they stowed in their desk drawers are long gone. In the Olympian corridors of power far above our heads, powerful forces that dictate our lives hurl thunderbolts at each other as they vie for money, power, and control. The trick is to stay out of their way and avoid becoming collateral damage.

Easy to say. Less easy to do.

Dr. Rockoff practices dermatology in Brookline, Mass. He is on the clinical faculty at Tufts University School of Medicine, Boston, and has taught senior medical students and other trainees for 30 years. Dr. Rockoff has contributed to the Under My Skin column in Skin & Allergy News since January 2002.

Myelofibrosis (MF), including primary MF and MF secondary to polycythemia vera or essential thrombocythemia, is a chronic, clinically heterogeneous hematologic malignancy characterized by inefficient hematopoiesis, bone marrow fibrosis, and shortened survival. Typical clinical manifestations include progressive splenomegaly, debilitating symptoms, and anemia. MF is associated with dysregulation of Janus kinase (JAK)-signal transducer and activator of transcription (JAK/STAT) pathway affecting hematopoiesis and inflammation. Ruxolitinib, an oral JAK1/JAK2 inhibitor, was approved for the treatment of patients with intermediate or high-risk MF based on the results of 2 phase 3 studies (Controlled MyeloFibrosis Study with Oral JAK Inhibitor Treatment [COMFORT]-I and COMFORT-II). In these trials, ruxolitinib treatment was associated with reductions in spleen size and symptom burden, and improvements in quality of life. The most common adverse events were dose-dependent cytopenias, which were managed by dose modifications, treatment interruptions, and red blood cell transfusions (for anemia). Ruxolitinib was effective regardless of MF type, risk status, or JAK2V617F mutation status, and across various other MF subpopulations. Two-year follow-up data from the COMFORT trials also demonstrate that ruxolitinib has durable efficacy and may be associated with a survival advantage relative to placebo and best available therapy. Preliminary data from ongoing studies support possible dosing strategies for patients with low platelet counts.

Click on the PDF icon at the top of this introduction to read the full article.

Myelofibrosis (MF), including primary MF and MF secondary to polycythemia vera or essential thrombocythemia, is a chronic, clinically heterogeneous hematologic malignancy characterized by inefficient hematopoiesis, bone marrow fibrosis, and shortened survival. Typical clinical manifestations include progressive splenomegaly, debilitating symptoms, and anemia. MF is associated with dysregulation of Janus kinase (JAK)-signal transducer and activator of transcription (JAK/STAT) pathway affecting hematopoiesis and inflammation. Ruxolitinib, an oral JAK1/JAK2 inhibitor, was approved for the treatment of patients with intermediate or high-risk MF based on the results of 2 phase 3 studies (Controlled MyeloFibrosis Study with Oral JAK Inhibitor Treatment [COMFORT]-I and COMFORT-II). In these trials, ruxolitinib treatment was associated with reductions in spleen size and symptom burden, and improvements in quality of life. The most common adverse events were dose-dependent cytopenias, which were managed by dose modifications, treatment interruptions, and red blood cell transfusions (for anemia). Ruxolitinib was effective regardless of MF type, risk status, or JAK2V617F mutation status, and across various other MF subpopulations. Two-year follow-up data from the COMFORT trials also demonstrate that ruxolitinib has durable efficacy and may be associated with a survival advantage relative to placebo and best available therapy. Preliminary data from ongoing studies support possible dosing strategies for patients with low platelet counts.

Click on the PDF icon at the top of this introduction to read the full article.

Myelofibrosis (MF), including primary MF and MF secondary to polycythemia vera or essential thrombocythemia, is a chronic, clinically heterogeneous hematologic malignancy characterized by inefficient hematopoiesis, bone marrow fibrosis, and shortened survival. Typical clinical manifestations include progressive splenomegaly, debilitating symptoms, and anemia. MF is associated with dysregulation of Janus kinase (JAK)-signal transducer and activator of transcription (JAK/STAT) pathway affecting hematopoiesis and inflammation. Ruxolitinib, an oral JAK1/JAK2 inhibitor, was approved for the treatment of patients with intermediate or high-risk MF based on the results of 2 phase 3 studies (Controlled MyeloFibrosis Study with Oral JAK Inhibitor Treatment [COMFORT]-I and COMFORT-II). In these trials, ruxolitinib treatment was associated with reductions in spleen size and symptom burden, and improvements in quality of life. The most common adverse events were dose-dependent cytopenias, which were managed by dose modifications, treatment interruptions, and red blood cell transfusions (for anemia). Ruxolitinib was effective regardless of MF type, risk status, or JAK2V617F mutation status, and across various other MF subpopulations. Two-year follow-up data from the COMFORT trials also demonstrate that ruxolitinib has durable efficacy and may be associated with a survival advantage relative to placebo and best available therapy. Preliminary data from ongoing studies support possible dosing strategies for patients with low platelet counts.

Click on the PDF icon at the top of this introduction to read the full article.