Vaping marijuana?

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Cannavaping—the inhalation of a cannabis-containing aerosol, created by a battery-driven, heated atomizer in e-cigarettes or similar devices1—is touted as a less expensive and safer alternative to smoking marijuana. It’s also gaining in popularity.2 One study of Connecticut high school students found that 5.4% had used e-cigarettes to vaporize cannabis.3 But what do we know about this new way to get high?

We know that those who wish to cannavape can easily obtain e-cigarettes from gas stations and tobacco shops. They then have to obtain a cartridge, filled with either hash oil or tetrahydrocannabinol-infused wax, to attach to the e-cigarette. These cartridges are available for purchase in states that have legalized the sale of marijuana. They also find their way into states where the sale of marijuana is not legal, and are purchased illegally for the purpose of cannavaping.

And while cannavaping does appear to reduce the cost of smoking marijuana,4 it has not been widely researched, nor determined to be safe.5

 

 

 

In fact, although marijuana has several important therapeutic and medicinal purposes, cannavaping the substance can result in medical concerns.6 The vaping aerosols of some compounds can induce lung pathology and may be carcinogenic, since they often contain a number of dangerous toxins.4

Chronic marijuana use can increase the likelihood of motor vehicles accidents, cognitive impairment, psychoses, and demotivation.4 It may predispose certain individuals to use other drugs and tobacco products and could increase the consumption of marijuana.4,5 Increased consumption could have a detrimental effect on intellect and behavior when used chronically—especially in youngsters, whose nervous systems are not yet fully matured.7-9

Because cannavaping has potentially deleterious effects, more regulations on the manufacture, distribution, access, and use are indicated—at least until research sheds more light on issues surrounding this practice.

Steven Lippman, MD; Devina Singh, MD
Louisville, KY

References

1. Varlet V, Concha-Lozano N, Berthlet A, et al. Drug vaping applied to cannabis: is “cannavaping” a therapeutic alternative to marijuana? Sci Rep. 2016;6:25599.

2. Giroud C, de Cesare M, Berthet A, et al. E-cigarettes: a review of new trends in cannabis use. Int J Environ Res Public Health. 2015;12:9988-10008.

3. Morean ME, Kong G, Camenga DR, et al. High school students’ use of electronic cigarettes to vaporize cannabis. Pediatrics. 2015;136:611-616.

4. Budney AJ, Sargent JD, Lee DC. Vaping cannabis (marijuana): parallel concerns to e-cigs? Addiction. 2015;110:1699-1704.

5. Cox B. Can the research community respond adequately to the health risks of vaping? Addiction. 2015;110:1709-1709.

6. Rong C, Lee Y, Carmona NE, et al. Cannabidiol in medical marijuana: research vistas and potential opportunities. Pharmacol Res. 2017;121:213-218.

7. Schweinsburg AD, Brown SA, Tapert SF. The influence of marijuana use on neurocognitive functioning in adolescents. Curr Drug Abuse Rev. 2008;1:99-111.

8. Meier MH, Caspi A, Ambler A, et al. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci USA. 2012;109:E2657-2664.

9. Castellanos-Ryan N, Pingault J, Parent S, et al. Adolescent cannabis use, change in neurocognitive function, and high-school graduation: a longitudinal study from early adolescence to young adulthood. Dev Psychopathol . 2017;29:1253-1266.

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Cannavaping—the inhalation of a cannabis-containing aerosol, created by a battery-driven, heated atomizer in e-cigarettes or similar devices1—is touted as a less expensive and safer alternative to smoking marijuana. It’s also gaining in popularity.2 One study of Connecticut high school students found that 5.4% had used e-cigarettes to vaporize cannabis.3 But what do we know about this new way to get high?

We know that those who wish to cannavape can easily obtain e-cigarettes from gas stations and tobacco shops. They then have to obtain a cartridge, filled with either hash oil or tetrahydrocannabinol-infused wax, to attach to the e-cigarette. These cartridges are available for purchase in states that have legalized the sale of marijuana. They also find their way into states where the sale of marijuana is not legal, and are purchased illegally for the purpose of cannavaping.

And while cannavaping does appear to reduce the cost of smoking marijuana,4 it has not been widely researched, nor determined to be safe.5

 

 

 

In fact, although marijuana has several important therapeutic and medicinal purposes, cannavaping the substance can result in medical concerns.6 The vaping aerosols of some compounds can induce lung pathology and may be carcinogenic, since they often contain a number of dangerous toxins.4

Chronic marijuana use can increase the likelihood of motor vehicles accidents, cognitive impairment, psychoses, and demotivation.4 It may predispose certain individuals to use other drugs and tobacco products and could increase the consumption of marijuana.4,5 Increased consumption could have a detrimental effect on intellect and behavior when used chronically—especially in youngsters, whose nervous systems are not yet fully matured.7-9

Because cannavaping has potentially deleterious effects, more regulations on the manufacture, distribution, access, and use are indicated—at least until research sheds more light on issues surrounding this practice.

Steven Lippman, MD; Devina Singh, MD
Louisville, KY

 

Cannavaping—the inhalation of a cannabis-containing aerosol, created by a battery-driven, heated atomizer in e-cigarettes or similar devices1—is touted as a less expensive and safer alternative to smoking marijuana. It’s also gaining in popularity.2 One study of Connecticut high school students found that 5.4% had used e-cigarettes to vaporize cannabis.3 But what do we know about this new way to get high?

We know that those who wish to cannavape can easily obtain e-cigarettes from gas stations and tobacco shops. They then have to obtain a cartridge, filled with either hash oil or tetrahydrocannabinol-infused wax, to attach to the e-cigarette. These cartridges are available for purchase in states that have legalized the sale of marijuana. They also find their way into states where the sale of marijuana is not legal, and are purchased illegally for the purpose of cannavaping.

And while cannavaping does appear to reduce the cost of smoking marijuana,4 it has not been widely researched, nor determined to be safe.5

 

 

 

In fact, although marijuana has several important therapeutic and medicinal purposes, cannavaping the substance can result in medical concerns.6 The vaping aerosols of some compounds can induce lung pathology and may be carcinogenic, since they often contain a number of dangerous toxins.4

Chronic marijuana use can increase the likelihood of motor vehicles accidents, cognitive impairment, psychoses, and demotivation.4 It may predispose certain individuals to use other drugs and tobacco products and could increase the consumption of marijuana.4,5 Increased consumption could have a detrimental effect on intellect and behavior when used chronically—especially in youngsters, whose nervous systems are not yet fully matured.7-9

Because cannavaping has potentially deleterious effects, more regulations on the manufacture, distribution, access, and use are indicated—at least until research sheds more light on issues surrounding this practice.

Steven Lippman, MD; Devina Singh, MD
Louisville, KY

References

1. Varlet V, Concha-Lozano N, Berthlet A, et al. Drug vaping applied to cannabis: is “cannavaping” a therapeutic alternative to marijuana? Sci Rep. 2016;6:25599.

2. Giroud C, de Cesare M, Berthet A, et al. E-cigarettes: a review of new trends in cannabis use. Int J Environ Res Public Health. 2015;12:9988-10008.

3. Morean ME, Kong G, Camenga DR, et al. High school students’ use of electronic cigarettes to vaporize cannabis. Pediatrics. 2015;136:611-616.

4. Budney AJ, Sargent JD, Lee DC. Vaping cannabis (marijuana): parallel concerns to e-cigs? Addiction. 2015;110:1699-1704.

5. Cox B. Can the research community respond adequately to the health risks of vaping? Addiction. 2015;110:1709-1709.

6. Rong C, Lee Y, Carmona NE, et al. Cannabidiol in medical marijuana: research vistas and potential opportunities. Pharmacol Res. 2017;121:213-218.

7. Schweinsburg AD, Brown SA, Tapert SF. The influence of marijuana use on neurocognitive functioning in adolescents. Curr Drug Abuse Rev. 2008;1:99-111.

8. Meier MH, Caspi A, Ambler A, et al. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci USA. 2012;109:E2657-2664.

9. Castellanos-Ryan N, Pingault J, Parent S, et al. Adolescent cannabis use, change in neurocognitive function, and high-school graduation: a longitudinal study from early adolescence to young adulthood. Dev Psychopathol . 2017;29:1253-1266.

References

1. Varlet V, Concha-Lozano N, Berthlet A, et al. Drug vaping applied to cannabis: is “cannavaping” a therapeutic alternative to marijuana? Sci Rep. 2016;6:25599.

2. Giroud C, de Cesare M, Berthet A, et al. E-cigarettes: a review of new trends in cannabis use. Int J Environ Res Public Health. 2015;12:9988-10008.

3. Morean ME, Kong G, Camenga DR, et al. High school students’ use of electronic cigarettes to vaporize cannabis. Pediatrics. 2015;136:611-616.

4. Budney AJ, Sargent JD, Lee DC. Vaping cannabis (marijuana): parallel concerns to e-cigs? Addiction. 2015;110:1699-1704.

5. Cox B. Can the research community respond adequately to the health risks of vaping? Addiction. 2015;110:1709-1709.

6. Rong C, Lee Y, Carmona NE, et al. Cannabidiol in medical marijuana: research vistas and potential opportunities. Pharmacol Res. 2017;121:213-218.

7. Schweinsburg AD, Brown SA, Tapert SF. The influence of marijuana use on neurocognitive functioning in adolescents. Curr Drug Abuse Rev. 2008;1:99-111.

8. Meier MH, Caspi A, Ambler A, et al. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci USA. 2012;109:E2657-2664.

9. Castellanos-Ryan N, Pingault J, Parent S, et al. Adolescent cannabis use, change in neurocognitive function, and high-school graduation: a longitudinal study from early adolescence to young adulthood. Dev Psychopathol . 2017;29:1253-1266.

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Treat gun violence like the public health crisis it is

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Last month’s mass shooting in Las Vegas, which killed 59 people and wounded 500, was committed by a single individual who legally purchased an arsenal that allowed him to fire hundreds of high-caliber bullets within minutes into a large crowd. This is just the latest in a series of high-profile mass killings that appear to be increasing in frequency.1

As terrifying as mass murders are, they account for only a small fraction of gun-related mortality. Everyday about 80 people in the United States are killed by a gun, usually by someone they know or by themselves (almost two-thirds of gun-related mortality involves suicide).2 No other developed country even comes close to our rate of gun-related violence.2

What to do? Recall anti-smoking efforts. Gun violence is a public health issue that should be addressed with tried and proven public health methods. A couple of examples from history hold valuable lessons. While tobacco-related mortality and morbidity remain public health concerns, we have made marked improvements and saved many lives through a series of public health interventions including increasing the price of tobacco products, restricting advertising and sales to minors, and prohibiting smoking in public areas, to name a few.3

 

 

 

These interventions occurred because the public recognized the threat of tobacco and was willing to adopt them. This was not always the case. During the first half of my life, smoking in public, including indoors at public events and even on airplanes, was accepted, and the “rights of smokers” were respected. This now seems inconceivable. Public health interventions work, and public perceptions and attitudes can change.

If we gather data and fund research, we can make changes to reduce deaths while maintaining the right to own a firearm.

Consider inroads made in driver safety, too. We have also made marked improvements in motor vehicle crash-related deaths and injuries.4 For decades, we have recorded hundreds of data points on every car crash resulting in a death in a comprehensive database—the Fatality Analysis Reporting System (FARS). These data have been used by researchers to identify causes of crashes and crash-related deaths and have led to improvements in car design and road safety. Additional factors leading to improved road safety include restrictions on the age at which one can drive and on drinking alcohol and driving.

We can achieve similar improvements in gun-related mortality if we establish and maintain a comprehensive database, encourage and fund research, and are willing to adopt some commonsense product improvements and ownership restrictions that, nevertheless, preserve the right for most to responsibly own a firearm.

Don’t you think it’s time?

References

1. Blair JP, Schweit KW. A study of active shooter incidents in the United States between 2000 and 2013. Texas State University and the Federal Bureau of Investigation, US Department of Justice, Washington, DC. 2014. Available at: https://www.fbi.gov/file-repository/active-shooter-study-2000-2013-1.pdf. Accessed October 16, 2017.

2. Wintemute GJ. The epidemiology of firearm violence in the twenty-first century United States. Annu Rev Public Health. 2015;36:5-19.

3. Centers for Disease Control and Prevention. Tobacco use—United States, 1900-1999. MMWR Morb Mortal Wkly Rep. 1999;48:986-993.

4. Centers for Disease Control and Prevention. Achievements in public health, 1900-1999 motor-vehicle safety: a 20th century public health achievement. MMWR Morb Mortal Wkly Rep. 1999;48:369-374.

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Last month’s mass shooting in Las Vegas, which killed 59 people and wounded 500, was committed by a single individual who legally purchased an arsenal that allowed him to fire hundreds of high-caliber bullets within minutes into a large crowd. This is just the latest in a series of high-profile mass killings that appear to be increasing in frequency.1

As terrifying as mass murders are, they account for only a small fraction of gun-related mortality. Everyday about 80 people in the United States are killed by a gun, usually by someone they know or by themselves (almost two-thirds of gun-related mortality involves suicide).2 No other developed country even comes close to our rate of gun-related violence.2

What to do? Recall anti-smoking efforts. Gun violence is a public health issue that should be addressed with tried and proven public health methods. A couple of examples from history hold valuable lessons. While tobacco-related mortality and morbidity remain public health concerns, we have made marked improvements and saved many lives through a series of public health interventions including increasing the price of tobacco products, restricting advertising and sales to minors, and prohibiting smoking in public areas, to name a few.3

 

 

 

These interventions occurred because the public recognized the threat of tobacco and was willing to adopt them. This was not always the case. During the first half of my life, smoking in public, including indoors at public events and even on airplanes, was accepted, and the “rights of smokers” were respected. This now seems inconceivable. Public health interventions work, and public perceptions and attitudes can change.

If we gather data and fund research, we can make changes to reduce deaths while maintaining the right to own a firearm.

Consider inroads made in driver safety, too. We have also made marked improvements in motor vehicle crash-related deaths and injuries.4 For decades, we have recorded hundreds of data points on every car crash resulting in a death in a comprehensive database—the Fatality Analysis Reporting System (FARS). These data have been used by researchers to identify causes of crashes and crash-related deaths and have led to improvements in car design and road safety. Additional factors leading to improved road safety include restrictions on the age at which one can drive and on drinking alcohol and driving.

We can achieve similar improvements in gun-related mortality if we establish and maintain a comprehensive database, encourage and fund research, and are willing to adopt some commonsense product improvements and ownership restrictions that, nevertheless, preserve the right for most to responsibly own a firearm.

Don’t you think it’s time?

 

Last month’s mass shooting in Las Vegas, which killed 59 people and wounded 500, was committed by a single individual who legally purchased an arsenal that allowed him to fire hundreds of high-caliber bullets within minutes into a large crowd. This is just the latest in a series of high-profile mass killings that appear to be increasing in frequency.1

As terrifying as mass murders are, they account for only a small fraction of gun-related mortality. Everyday about 80 people in the United States are killed by a gun, usually by someone they know or by themselves (almost two-thirds of gun-related mortality involves suicide).2 No other developed country even comes close to our rate of gun-related violence.2

What to do? Recall anti-smoking efforts. Gun violence is a public health issue that should be addressed with tried and proven public health methods. A couple of examples from history hold valuable lessons. While tobacco-related mortality and morbidity remain public health concerns, we have made marked improvements and saved many lives through a series of public health interventions including increasing the price of tobacco products, restricting advertising and sales to minors, and prohibiting smoking in public areas, to name a few.3

 

 

 

These interventions occurred because the public recognized the threat of tobacco and was willing to adopt them. This was not always the case. During the first half of my life, smoking in public, including indoors at public events and even on airplanes, was accepted, and the “rights of smokers” were respected. This now seems inconceivable. Public health interventions work, and public perceptions and attitudes can change.

If we gather data and fund research, we can make changes to reduce deaths while maintaining the right to own a firearm.

Consider inroads made in driver safety, too. We have also made marked improvements in motor vehicle crash-related deaths and injuries.4 For decades, we have recorded hundreds of data points on every car crash resulting in a death in a comprehensive database—the Fatality Analysis Reporting System (FARS). These data have been used by researchers to identify causes of crashes and crash-related deaths and have led to improvements in car design and road safety. Additional factors leading to improved road safety include restrictions on the age at which one can drive and on drinking alcohol and driving.

We can achieve similar improvements in gun-related mortality if we establish and maintain a comprehensive database, encourage and fund research, and are willing to adopt some commonsense product improvements and ownership restrictions that, nevertheless, preserve the right for most to responsibly own a firearm.

Don’t you think it’s time?

References

1. Blair JP, Schweit KW. A study of active shooter incidents in the United States between 2000 and 2013. Texas State University and the Federal Bureau of Investigation, US Department of Justice, Washington, DC. 2014. Available at: https://www.fbi.gov/file-repository/active-shooter-study-2000-2013-1.pdf. Accessed October 16, 2017.

2. Wintemute GJ. The epidemiology of firearm violence in the twenty-first century United States. Annu Rev Public Health. 2015;36:5-19.

3. Centers for Disease Control and Prevention. Tobacco use—United States, 1900-1999. MMWR Morb Mortal Wkly Rep. 1999;48:986-993.

4. Centers for Disease Control and Prevention. Achievements in public health, 1900-1999 motor-vehicle safety: a 20th century public health achievement. MMWR Morb Mortal Wkly Rep. 1999;48:369-374.

References

1. Blair JP, Schweit KW. A study of active shooter incidents in the United States between 2000 and 2013. Texas State University and the Federal Bureau of Investigation, US Department of Justice, Washington, DC. 2014. Available at: https://www.fbi.gov/file-repository/active-shooter-study-2000-2013-1.pdf. Accessed October 16, 2017.

2. Wintemute GJ. The epidemiology of firearm violence in the twenty-first century United States. Annu Rev Public Health. 2015;36:5-19.

3. Centers for Disease Control and Prevention. Tobacco use—United States, 1900-1999. MMWR Morb Mortal Wkly Rep. 1999;48:986-993.

4. Centers for Disease Control and Prevention. Achievements in public health, 1900-1999 motor-vehicle safety: a 20th century public health achievement. MMWR Morb Mortal Wkly Rep. 1999;48:369-374.

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Syphilis and the Dermatologist

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Once upon a time, and long ago, dermatology journals included “syphilology” in their names. The first dermatologic journal published in the United States was the American Journal of Syphilology and Dermatology.1 In October 1882 the Journal of Cutaneous and Venereal Diseases appeared and subsequently renamed several times from 1882 to 1919: Journal of Cutaneous Diseases and Genitourinary Diseases and the Journal of Cutaneous Diseases, Including Syphilis. When the American Medical Association (AMA) assumed control, this publication obtained a new name: Archives of Dermatology and Syphilology; in January 1955 syphilology was deleted from the title. According to an editorial in that issue, the rationale for dropping the word syphilology was as follows: “The diagnosis and treatment of patients with syphilis is no longer an important part of dermatologic practice. . . . Few dermatologists now have patients with syphilis; in fact, there are decidedly fewer patients with syphilis, and so continuance of the old label, ‘Syphilology,’ on this publication seems no longer warranted.”1 Needless to say, this decision ignored the obvious fact that the majority of dermatologists traditionally were well trained in and clinically practiced venereology, particularly the management of syphilis,2,3 which makes sense, considering that many of the clinical manifestations of syphilis involve the skin, hair, and oral mucosa. My own mentor and former Baylor College of Medicine dermatology department chair, Dr. John Knox, authored 3 dozen major publications regarding the diagnosis, treatment, and immunology of syphilis. During his chairmanship, all residents were required to rotate in the Harris County sexually transmitted disease (STD) clinic on a weekly basis.

I am confident that the decision to drop “syphilology” from the journal title also was based on the unduly optimistic assumption that syphilis would soon become a rare disease due to the availability of penicillin. Indeed, the Centers for Disease Control and Prevention in the United States has periodically announced strategic programs designed to eradicate syphilis!4 This rosy outlook reached a fever pitch in 2000 when the number of cases (5979) and the incidence (2.1 cases per 100,000 population) of primary and secondary syphilis reached an all-time low in the United States.5

Unfortunately, no one could accurately predict the future. Although the number of cases and incidence of early infectious syphilis have fluctuated widely since the 1940s, we currently are in a dire period of syphilis resurgence; the largest number of cases (27,814) and the highest incidence rate of primary and secondary syphilis (8.7 cases per 100,000 population) since 1994 were reported in 2016,6 which illustrates the inability of public health initiatives to eliminate syphilis, largely due to the inability of health authorities, health care providers, teachers, parents, clergy, and peer groups to alter sexual behaviors or modify other socioeconomic factors.7 Thus, syphilis lives on! Nobody could have predicted the easy availability of oral contraceptives and the ensuing sexual revolution of the 1960s or the advent of erectile dysfunction drugs decades later that led to increasing STDs among older patients.8 Nobody could have predicted the wholesale acceptance of casual sexual intercourse as popularized on television and in the movies or the pervasive use of sexual images in advertising. Nobody could have predicted the modern phenomena of “booty-call relationships,” “friends with benefits,” and “sexting,” or the nearly ubiquitous and increasingly legal use of noninjectable mind-altering drugs, all of which facilitate the perpetuation of STDs.9-11 Finally, those who removed “syphilology” from that journal title certainly did not foresee the worldwide epidemic now known as human immunodeficiency virus/AIDS, which has most assuredly helped keep syphilis a modern day menace.12-14

How have dermatologists been impacted? Our journals and our teachers have deemphasized STDs, including syphilis, in modern times, yet we are faced with a disease carrying serious, if not often fatal, consequences that is simply refusing to disappear (contrary to wishful thinking). Dermatologists are, however, in a perfect epidemiological position to help in the war against Treponema pallidum, the bacterium that causes syphilis. We frequently see adolescent patients for warts and acne, and we often diagnose and help care for patients with human immunodeficiency virus. We obliterate actinic keratoses and perform cosmetic procedures on those who rely on erectile dysfunction drugs (or their partners do). Who better than a dermatologist to recognize in these high-risk constituencies, and others, that patchy hair loss may represent syphilitic alopecia and that extragenital chancres can mimic nonmelanoma skin cancer? Who better than the dermatologist to distinguish between oral mucous patches and orolabial herpes? Who better than the dermatologist to diagnose the annular syphilid of the face, or ostraceous, florid nodular, or ulceronecrotic lesions of lues maligna? Who better than the dermatologist to differentiate condylomata lata from external genital warts?

I would suggest that the responsible dermatologist become reacquainted with syphilis, in all its various manifestations. I would further suggest that our dermatology training centers spend more time diligently teaching residents about syphilis and other STDs. In conclusion, I fervently hope that organized dermatology will once again dutifully consider venereal disease to be a critical part of our specialty’s skill set.

References
  1. Editorial. AMA Arch Dermatol. 1955;71:1.
  2. Shelley WB. Major contributors to American dermatology—1876 to 1926. Arch Dermatol. 1976;112:1642-1646.
  3. Lobitz WC Jr. Major contributions of American dermatologists—1926 to 1976. Arch Dermatol. 1976;112:1646-1650.
  4. Hook EW 3rd. Elimination of syphilis transmission in the United States: historic perspectives and practical considerations. Trans Am ClinClimatol Assoc. 1999;110:195-203.
  5. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2000. Atlanta, GA: Department of Health and Human Services; 2001.
  6. 2016 Sexually transmitted diseases surveillance: syphilis. Centers for Disease Control and Prevention website. https://www.cdc.gov/std/stats16/syphilis.htm. Updated September 26, 2017. Accessed October 20, 2017.
  7. Shockman S, Buescher LS, Stone SP. Syphilis in the United States. Clin Dermatol. 2014;32:213-218.
  8. Jena AB, Goldman DP, Kamdar A, et al. Sexually transmitted diseases among users of erectile dysfunction drugs: analysis of claims data. Ann Intern Med. 2010;153:1-7.
  9. Jonason PK, Li NP, Richardson J. Positioning the booty-call relationship on the spectrum of relationships: sexual but more emotional than one-night stands. J Sex Res. 2011;48:486-495.
  10. Temple JR, Choi H. Longitudinal association between teen sexting and sexual behavior. Pediatrics. 2014;134:E1287-E1292.
  11. Regan R, Dyer TP, Gooding T, et al. Associations between drug use and sexual risks among heterosexual men in the Philippines [published online July 22, 2013]. Int J STD AIDS. 2013;24:969-976.
  12. Flagg EW, Weinstock HS, Frazier EL, et al. Bacterial sexually transmitted infections among HIV-infected patients in the United States: estimates from the Medical Monitoring Project. Sex Transm Dis. 2015;42:171-179.
  13. Shilaih M, Marzel A, Braun DL, et al; Swiss HIV Cohort Study. Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. Medicine (Baltimore). 2017;96:E5849.
  14. Salado-Rasmussen K. Syphilis and HIV co-infection. epidemiology, treatment and molecular typing of Treponema pallidum. Dan Med J. 2015;62:B5176.
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Correspondence: Ted Rosen, MD, 2815 Plumb, Houston, TX 77005 ([email protected]).

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Correspondence: Ted Rosen, MD, 2815 Plumb, Houston, TX 77005 ([email protected]).

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Once upon a time, and long ago, dermatology journals included “syphilology” in their names. The first dermatologic journal published in the United States was the American Journal of Syphilology and Dermatology.1 In October 1882 the Journal of Cutaneous and Venereal Diseases appeared and subsequently renamed several times from 1882 to 1919: Journal of Cutaneous Diseases and Genitourinary Diseases and the Journal of Cutaneous Diseases, Including Syphilis. When the American Medical Association (AMA) assumed control, this publication obtained a new name: Archives of Dermatology and Syphilology; in January 1955 syphilology was deleted from the title. According to an editorial in that issue, the rationale for dropping the word syphilology was as follows: “The diagnosis and treatment of patients with syphilis is no longer an important part of dermatologic practice. . . . Few dermatologists now have patients with syphilis; in fact, there are decidedly fewer patients with syphilis, and so continuance of the old label, ‘Syphilology,’ on this publication seems no longer warranted.”1 Needless to say, this decision ignored the obvious fact that the majority of dermatologists traditionally were well trained in and clinically practiced venereology, particularly the management of syphilis,2,3 which makes sense, considering that many of the clinical manifestations of syphilis involve the skin, hair, and oral mucosa. My own mentor and former Baylor College of Medicine dermatology department chair, Dr. John Knox, authored 3 dozen major publications regarding the diagnosis, treatment, and immunology of syphilis. During his chairmanship, all residents were required to rotate in the Harris County sexually transmitted disease (STD) clinic on a weekly basis.

I am confident that the decision to drop “syphilology” from the journal title also was based on the unduly optimistic assumption that syphilis would soon become a rare disease due to the availability of penicillin. Indeed, the Centers for Disease Control and Prevention in the United States has periodically announced strategic programs designed to eradicate syphilis!4 This rosy outlook reached a fever pitch in 2000 when the number of cases (5979) and the incidence (2.1 cases per 100,000 population) of primary and secondary syphilis reached an all-time low in the United States.5

Unfortunately, no one could accurately predict the future. Although the number of cases and incidence of early infectious syphilis have fluctuated widely since the 1940s, we currently are in a dire period of syphilis resurgence; the largest number of cases (27,814) and the highest incidence rate of primary and secondary syphilis (8.7 cases per 100,000 population) since 1994 were reported in 2016,6 which illustrates the inability of public health initiatives to eliminate syphilis, largely due to the inability of health authorities, health care providers, teachers, parents, clergy, and peer groups to alter sexual behaviors or modify other socioeconomic factors.7 Thus, syphilis lives on! Nobody could have predicted the easy availability of oral contraceptives and the ensuing sexual revolution of the 1960s or the advent of erectile dysfunction drugs decades later that led to increasing STDs among older patients.8 Nobody could have predicted the wholesale acceptance of casual sexual intercourse as popularized on television and in the movies or the pervasive use of sexual images in advertising. Nobody could have predicted the modern phenomena of “booty-call relationships,” “friends with benefits,” and “sexting,” or the nearly ubiquitous and increasingly legal use of noninjectable mind-altering drugs, all of which facilitate the perpetuation of STDs.9-11 Finally, those who removed “syphilology” from that journal title certainly did not foresee the worldwide epidemic now known as human immunodeficiency virus/AIDS, which has most assuredly helped keep syphilis a modern day menace.12-14

How have dermatologists been impacted? Our journals and our teachers have deemphasized STDs, including syphilis, in modern times, yet we are faced with a disease carrying serious, if not often fatal, consequences that is simply refusing to disappear (contrary to wishful thinking). Dermatologists are, however, in a perfect epidemiological position to help in the war against Treponema pallidum, the bacterium that causes syphilis. We frequently see adolescent patients for warts and acne, and we often diagnose and help care for patients with human immunodeficiency virus. We obliterate actinic keratoses and perform cosmetic procedures on those who rely on erectile dysfunction drugs (or their partners do). Who better than a dermatologist to recognize in these high-risk constituencies, and others, that patchy hair loss may represent syphilitic alopecia and that extragenital chancres can mimic nonmelanoma skin cancer? Who better than the dermatologist to distinguish between oral mucous patches and orolabial herpes? Who better than the dermatologist to diagnose the annular syphilid of the face, or ostraceous, florid nodular, or ulceronecrotic lesions of lues maligna? Who better than the dermatologist to differentiate condylomata lata from external genital warts?

I would suggest that the responsible dermatologist become reacquainted with syphilis, in all its various manifestations. I would further suggest that our dermatology training centers spend more time diligently teaching residents about syphilis and other STDs. In conclusion, I fervently hope that organized dermatology will once again dutifully consider venereal disease to be a critical part of our specialty’s skill set.

Once upon a time, and long ago, dermatology journals included “syphilology” in their names. The first dermatologic journal published in the United States was the American Journal of Syphilology and Dermatology.1 In October 1882 the Journal of Cutaneous and Venereal Diseases appeared and subsequently renamed several times from 1882 to 1919: Journal of Cutaneous Diseases and Genitourinary Diseases and the Journal of Cutaneous Diseases, Including Syphilis. When the American Medical Association (AMA) assumed control, this publication obtained a new name: Archives of Dermatology and Syphilology; in January 1955 syphilology was deleted from the title. According to an editorial in that issue, the rationale for dropping the word syphilology was as follows: “The diagnosis and treatment of patients with syphilis is no longer an important part of dermatologic practice. . . . Few dermatologists now have patients with syphilis; in fact, there are decidedly fewer patients with syphilis, and so continuance of the old label, ‘Syphilology,’ on this publication seems no longer warranted.”1 Needless to say, this decision ignored the obvious fact that the majority of dermatologists traditionally were well trained in and clinically practiced venereology, particularly the management of syphilis,2,3 which makes sense, considering that many of the clinical manifestations of syphilis involve the skin, hair, and oral mucosa. My own mentor and former Baylor College of Medicine dermatology department chair, Dr. John Knox, authored 3 dozen major publications regarding the diagnosis, treatment, and immunology of syphilis. During his chairmanship, all residents were required to rotate in the Harris County sexually transmitted disease (STD) clinic on a weekly basis.

I am confident that the decision to drop “syphilology” from the journal title also was based on the unduly optimistic assumption that syphilis would soon become a rare disease due to the availability of penicillin. Indeed, the Centers for Disease Control and Prevention in the United States has periodically announced strategic programs designed to eradicate syphilis!4 This rosy outlook reached a fever pitch in 2000 when the number of cases (5979) and the incidence (2.1 cases per 100,000 population) of primary and secondary syphilis reached an all-time low in the United States.5

Unfortunately, no one could accurately predict the future. Although the number of cases and incidence of early infectious syphilis have fluctuated widely since the 1940s, we currently are in a dire period of syphilis resurgence; the largest number of cases (27,814) and the highest incidence rate of primary and secondary syphilis (8.7 cases per 100,000 population) since 1994 were reported in 2016,6 which illustrates the inability of public health initiatives to eliminate syphilis, largely due to the inability of health authorities, health care providers, teachers, parents, clergy, and peer groups to alter sexual behaviors or modify other socioeconomic factors.7 Thus, syphilis lives on! Nobody could have predicted the easy availability of oral contraceptives and the ensuing sexual revolution of the 1960s or the advent of erectile dysfunction drugs decades later that led to increasing STDs among older patients.8 Nobody could have predicted the wholesale acceptance of casual sexual intercourse as popularized on television and in the movies or the pervasive use of sexual images in advertising. Nobody could have predicted the modern phenomena of “booty-call relationships,” “friends with benefits,” and “sexting,” or the nearly ubiquitous and increasingly legal use of noninjectable mind-altering drugs, all of which facilitate the perpetuation of STDs.9-11 Finally, those who removed “syphilology” from that journal title certainly did not foresee the worldwide epidemic now known as human immunodeficiency virus/AIDS, which has most assuredly helped keep syphilis a modern day menace.12-14

How have dermatologists been impacted? Our journals and our teachers have deemphasized STDs, including syphilis, in modern times, yet we are faced with a disease carrying serious, if not often fatal, consequences that is simply refusing to disappear (contrary to wishful thinking). Dermatologists are, however, in a perfect epidemiological position to help in the war against Treponema pallidum, the bacterium that causes syphilis. We frequently see adolescent patients for warts and acne, and we often diagnose and help care for patients with human immunodeficiency virus. We obliterate actinic keratoses and perform cosmetic procedures on those who rely on erectile dysfunction drugs (or their partners do). Who better than a dermatologist to recognize in these high-risk constituencies, and others, that patchy hair loss may represent syphilitic alopecia and that extragenital chancres can mimic nonmelanoma skin cancer? Who better than the dermatologist to distinguish between oral mucous patches and orolabial herpes? Who better than the dermatologist to diagnose the annular syphilid of the face, or ostraceous, florid nodular, or ulceronecrotic lesions of lues maligna? Who better than the dermatologist to differentiate condylomata lata from external genital warts?

I would suggest that the responsible dermatologist become reacquainted with syphilis, in all its various manifestations. I would further suggest that our dermatology training centers spend more time diligently teaching residents about syphilis and other STDs. In conclusion, I fervently hope that organized dermatology will once again dutifully consider venereal disease to be a critical part of our specialty’s skill set.

References
  1. Editorial. AMA Arch Dermatol. 1955;71:1.
  2. Shelley WB. Major contributors to American dermatology—1876 to 1926. Arch Dermatol. 1976;112:1642-1646.
  3. Lobitz WC Jr. Major contributions of American dermatologists—1926 to 1976. Arch Dermatol. 1976;112:1646-1650.
  4. Hook EW 3rd. Elimination of syphilis transmission in the United States: historic perspectives and practical considerations. Trans Am ClinClimatol Assoc. 1999;110:195-203.
  5. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2000. Atlanta, GA: Department of Health and Human Services; 2001.
  6. 2016 Sexually transmitted diseases surveillance: syphilis. Centers for Disease Control and Prevention website. https://www.cdc.gov/std/stats16/syphilis.htm. Updated September 26, 2017. Accessed October 20, 2017.
  7. Shockman S, Buescher LS, Stone SP. Syphilis in the United States. Clin Dermatol. 2014;32:213-218.
  8. Jena AB, Goldman DP, Kamdar A, et al. Sexually transmitted diseases among users of erectile dysfunction drugs: analysis of claims data. Ann Intern Med. 2010;153:1-7.
  9. Jonason PK, Li NP, Richardson J. Positioning the booty-call relationship on the spectrum of relationships: sexual but more emotional than one-night stands. J Sex Res. 2011;48:486-495.
  10. Temple JR, Choi H. Longitudinal association between teen sexting and sexual behavior. Pediatrics. 2014;134:E1287-E1292.
  11. Regan R, Dyer TP, Gooding T, et al. Associations between drug use and sexual risks among heterosexual men in the Philippines [published online July 22, 2013]. Int J STD AIDS. 2013;24:969-976.
  12. Flagg EW, Weinstock HS, Frazier EL, et al. Bacterial sexually transmitted infections among HIV-infected patients in the United States: estimates from the Medical Monitoring Project. Sex Transm Dis. 2015;42:171-179.
  13. Shilaih M, Marzel A, Braun DL, et al; Swiss HIV Cohort Study. Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. Medicine (Baltimore). 2017;96:E5849.
  14. Salado-Rasmussen K. Syphilis and HIV co-infection. epidemiology, treatment and molecular typing of Treponema pallidum. Dan Med J. 2015;62:B5176.
References
  1. Editorial. AMA Arch Dermatol. 1955;71:1.
  2. Shelley WB. Major contributors to American dermatology—1876 to 1926. Arch Dermatol. 1976;112:1642-1646.
  3. Lobitz WC Jr. Major contributions of American dermatologists—1926 to 1976. Arch Dermatol. 1976;112:1646-1650.
  4. Hook EW 3rd. Elimination of syphilis transmission in the United States: historic perspectives and practical considerations. Trans Am ClinClimatol Assoc. 1999;110:195-203.
  5. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2000. Atlanta, GA: Department of Health and Human Services; 2001.
  6. 2016 Sexually transmitted diseases surveillance: syphilis. Centers for Disease Control and Prevention website. https://www.cdc.gov/std/stats16/syphilis.htm. Updated September 26, 2017. Accessed October 20, 2017.
  7. Shockman S, Buescher LS, Stone SP. Syphilis in the United States. Clin Dermatol. 2014;32:213-218.
  8. Jena AB, Goldman DP, Kamdar A, et al. Sexually transmitted diseases among users of erectile dysfunction drugs: analysis of claims data. Ann Intern Med. 2010;153:1-7.
  9. Jonason PK, Li NP, Richardson J. Positioning the booty-call relationship on the spectrum of relationships: sexual but more emotional than one-night stands. J Sex Res. 2011;48:486-495.
  10. Temple JR, Choi H. Longitudinal association between teen sexting and sexual behavior. Pediatrics. 2014;134:E1287-E1292.
  11. Regan R, Dyer TP, Gooding T, et al. Associations between drug use and sexual risks among heterosexual men in the Philippines [published online July 22, 2013]. Int J STD AIDS. 2013;24:969-976.
  12. Flagg EW, Weinstock HS, Frazier EL, et al. Bacterial sexually transmitted infections among HIV-infected patients in the United States: estimates from the Medical Monitoring Project. Sex Transm Dis. 2015;42:171-179.
  13. Shilaih M, Marzel A, Braun DL, et al; Swiss HIV Cohort Study. Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. Medicine (Baltimore). 2017;96:E5849.
  14. Salado-Rasmussen K. Syphilis and HIV co-infection. epidemiology, treatment and molecular typing of Treponema pallidum. Dan Med J. 2015;62:B5176.
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Children and trauma: How Sesame Street can help

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Nearly half of American children have faced one adverse childhood experience (ACE), according to new analysis of the 2016 National Survey of Children’s Health, and more than 20% have had two ACEs or more. This may include abuse or neglect, witnessing violence, parental substance abuse, mental illness, or incarceration. And from news headlines, we are all too aware of other traumas children face, such as natural disasters and mass violence.

Sesame Workshop 2017
The presence of a caring adult makes all the difference in the life of a child coping with the effects of trauma.
While some stress in early life is normal, chronic exposure to traumatic experiences can become toxic. Children who have had multiple ACEs are at higher risk for challenges affecting development and learning, and are more likely to face serious health issues as an adult. The groundbreaking Adverse Childhood Experiences study found that, as the number of ACEs increases, so does the risk for cancer, heart disease, and diabetes, as well as alcohol abuse and drug use, obesity, and depression.

But we know that children are remarkably resilient, and trauma does not have to define their trajectory. With the right tools and support, the effects of trauma can be mitigated, and children can build coping skills and resiliency for a healthy, promising future.

Sesame Workshop 2017
Adults can help children express themselves … even when children don't have the words.
That’s where Sesame Street comes in. You may know us as the TV show, but as a nonprofit educational organization, we have nearly 50 years’ experience working in communities to address developmental, physical, and emotional needs of children. Over the years, we have addressed difficult topics, such as death and illness, divorce, and incarceration in a “Sesame way” – through the lens of a child, with content featuring the iconic Sesame Street Muppets, loved by children and trusted by parents and providers.

When we began hearing from community service partners and child development experts that there was a critical need for resources to help children cope with trauma, we felt we could help.

Traumatic experiences can disrupt brain development, but when children have hope, when they feel seen and heard by caring adults who can guide them through those crucial resilience-building techniques, the impact of ACEs can be mitigated, and children can be set on the road to healing and stability.

With support from the Robert Wood Johnson Foundation and other funders, Sesame Workshop set out to create content for universal coping strategies to address “big feelings” like anger, anxiety, and sadness. To do this, we enlisted the pediatric community and professionals in the field, grounding our approach in the latest research. Then we used our proven model to produce resources that could engage and comfort children while building coping skills and foster crucial nurturing connections between children and the adults in their lives.

Our free materials – some are targeted for children and others are for providers – include videos, storybooks, and digital activities in English and Spanish. They are all available at sesamestreetincommunities.org/topics/traumatic-experiences.

Sesame Workshop 2017
Trauma's a big deal -- but Big Bird's got a supportive friend who gives big hugs.
We know that pediatricians and other pediatric providers are uniquely situated to identify children who are at risk, and can, in turn, equip families with resources. And we created these resources with such providers in mind: What makes our tools so effective is that they can be integrated into any intervention or service, enlisting our lovable Muppets as guides. Watching Elmo or Big Bird talk about their emotions can provide comfort to children coping with big feelings of their own.

In one video called “Comfy Cozy Nest,” when Big Bird faces an unspecified difficult situation, he learns to think of his nest as a “safe space” with comforting items like his teddy bear and Granny Bird’s birdseed cookies. This is a place he can go in his imagination to make himself feel safe. In others, Elmo builds a blanket fort to feel secure and the Count teaches Cookie Monster a breathing strategy to help him relax.

In addition to engaging materials for children, providers can find professional development workshops, webinars, and other adult-facing content that includes, as part of our trauma content, a powerful animation to help parents and caregivers understand the impact of domestic violence from a child’s perspective.

Sesame Street Workshop
Dr. Jeanette Betancourt with Elmo
Our trauma content is part of Sesame Street in Communities, a first-of-its-kind initiative to help the pediatric community, providers, parents, and caregivers give children a strong and healthy start. Sesame Street in Communities offers hundreds of free, multimedia tools to help children as they grow through the critical developmental window of birth through age 6 years. In addition to our new resources around traumatic experiences, Sesame Street in Communities pulls together decades of content for providers and families around early math and literacy, healthy habits, food insecurity, handling emergencies, and more. All resources are available for free in English and Spanish at www.sesamestreetincommunities.org.

No one plays a more vital role in children’s health and well-being than pediatricians, nurse practitioners, and family physicians. Our hope is that Sesame Street in Communities will allow us to work together, to help children everywhere grow smarter, stronger, and kinder.

Dr. Betancourt is the senior vice president for U.S. social impact at Sesame Workshop, the nonprofit media and educational organization behind Sesame Street, in New York.

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Nearly half of American children have faced one adverse childhood experience (ACE), according to new analysis of the 2016 National Survey of Children’s Health, and more than 20% have had two ACEs or more. This may include abuse or neglect, witnessing violence, parental substance abuse, mental illness, or incarceration. And from news headlines, we are all too aware of other traumas children face, such as natural disasters and mass violence.

Sesame Workshop 2017
The presence of a caring adult makes all the difference in the life of a child coping with the effects of trauma.
While some stress in early life is normal, chronic exposure to traumatic experiences can become toxic. Children who have had multiple ACEs are at higher risk for challenges affecting development and learning, and are more likely to face serious health issues as an adult. The groundbreaking Adverse Childhood Experiences study found that, as the number of ACEs increases, so does the risk for cancer, heart disease, and diabetes, as well as alcohol abuse and drug use, obesity, and depression.

But we know that children are remarkably resilient, and trauma does not have to define their trajectory. With the right tools and support, the effects of trauma can be mitigated, and children can build coping skills and resiliency for a healthy, promising future.

Sesame Workshop 2017
Adults can help children express themselves … even when children don't have the words.
That’s where Sesame Street comes in. You may know us as the TV show, but as a nonprofit educational organization, we have nearly 50 years’ experience working in communities to address developmental, physical, and emotional needs of children. Over the years, we have addressed difficult topics, such as death and illness, divorce, and incarceration in a “Sesame way” – through the lens of a child, with content featuring the iconic Sesame Street Muppets, loved by children and trusted by parents and providers.

When we began hearing from community service partners and child development experts that there was a critical need for resources to help children cope with trauma, we felt we could help.

Traumatic experiences can disrupt brain development, but when children have hope, when they feel seen and heard by caring adults who can guide them through those crucial resilience-building techniques, the impact of ACEs can be mitigated, and children can be set on the road to healing and stability.

With support from the Robert Wood Johnson Foundation and other funders, Sesame Workshop set out to create content for universal coping strategies to address “big feelings” like anger, anxiety, and sadness. To do this, we enlisted the pediatric community and professionals in the field, grounding our approach in the latest research. Then we used our proven model to produce resources that could engage and comfort children while building coping skills and foster crucial nurturing connections between children and the adults in their lives.

Our free materials – some are targeted for children and others are for providers – include videos, storybooks, and digital activities in English and Spanish. They are all available at sesamestreetincommunities.org/topics/traumatic-experiences.

Sesame Workshop 2017
Trauma's a big deal -- but Big Bird's got a supportive friend who gives big hugs.
We know that pediatricians and other pediatric providers are uniquely situated to identify children who are at risk, and can, in turn, equip families with resources. And we created these resources with such providers in mind: What makes our tools so effective is that they can be integrated into any intervention or service, enlisting our lovable Muppets as guides. Watching Elmo or Big Bird talk about their emotions can provide comfort to children coping with big feelings of their own.

In one video called “Comfy Cozy Nest,” when Big Bird faces an unspecified difficult situation, he learns to think of his nest as a “safe space” with comforting items like his teddy bear and Granny Bird’s birdseed cookies. This is a place he can go in his imagination to make himself feel safe. In others, Elmo builds a blanket fort to feel secure and the Count teaches Cookie Monster a breathing strategy to help him relax.

In addition to engaging materials for children, providers can find professional development workshops, webinars, and other adult-facing content that includes, as part of our trauma content, a powerful animation to help parents and caregivers understand the impact of domestic violence from a child’s perspective.

Sesame Street Workshop
Dr. Jeanette Betancourt with Elmo
Our trauma content is part of Sesame Street in Communities, a first-of-its-kind initiative to help the pediatric community, providers, parents, and caregivers give children a strong and healthy start. Sesame Street in Communities offers hundreds of free, multimedia tools to help children as they grow through the critical developmental window of birth through age 6 years. In addition to our new resources around traumatic experiences, Sesame Street in Communities pulls together decades of content for providers and families around early math and literacy, healthy habits, food insecurity, handling emergencies, and more. All resources are available for free in English and Spanish at www.sesamestreetincommunities.org.

No one plays a more vital role in children’s health and well-being than pediatricians, nurse practitioners, and family physicians. Our hope is that Sesame Street in Communities will allow us to work together, to help children everywhere grow smarter, stronger, and kinder.

Dr. Betancourt is the senior vice president for U.S. social impact at Sesame Workshop, the nonprofit media and educational organization behind Sesame Street, in New York.

 

Nearly half of American children have faced one adverse childhood experience (ACE), according to new analysis of the 2016 National Survey of Children’s Health, and more than 20% have had two ACEs or more. This may include abuse or neglect, witnessing violence, parental substance abuse, mental illness, or incarceration. And from news headlines, we are all too aware of other traumas children face, such as natural disasters and mass violence.

Sesame Workshop 2017
The presence of a caring adult makes all the difference in the life of a child coping with the effects of trauma.
While some stress in early life is normal, chronic exposure to traumatic experiences can become toxic. Children who have had multiple ACEs are at higher risk for challenges affecting development and learning, and are more likely to face serious health issues as an adult. The groundbreaking Adverse Childhood Experiences study found that, as the number of ACEs increases, so does the risk for cancer, heart disease, and diabetes, as well as alcohol abuse and drug use, obesity, and depression.

But we know that children are remarkably resilient, and trauma does not have to define their trajectory. With the right tools and support, the effects of trauma can be mitigated, and children can build coping skills and resiliency for a healthy, promising future.

Sesame Workshop 2017
Adults can help children express themselves … even when children don't have the words.
That’s where Sesame Street comes in. You may know us as the TV show, but as a nonprofit educational organization, we have nearly 50 years’ experience working in communities to address developmental, physical, and emotional needs of children. Over the years, we have addressed difficult topics, such as death and illness, divorce, and incarceration in a “Sesame way” – through the lens of a child, with content featuring the iconic Sesame Street Muppets, loved by children and trusted by parents and providers.

When we began hearing from community service partners and child development experts that there was a critical need for resources to help children cope with trauma, we felt we could help.

Traumatic experiences can disrupt brain development, but when children have hope, when they feel seen and heard by caring adults who can guide them through those crucial resilience-building techniques, the impact of ACEs can be mitigated, and children can be set on the road to healing and stability.

With support from the Robert Wood Johnson Foundation and other funders, Sesame Workshop set out to create content for universal coping strategies to address “big feelings” like anger, anxiety, and sadness. To do this, we enlisted the pediatric community and professionals in the field, grounding our approach in the latest research. Then we used our proven model to produce resources that could engage and comfort children while building coping skills and foster crucial nurturing connections between children and the adults in their lives.

Our free materials – some are targeted for children and others are for providers – include videos, storybooks, and digital activities in English and Spanish. They are all available at sesamestreetincommunities.org/topics/traumatic-experiences.

Sesame Workshop 2017
Trauma's a big deal -- but Big Bird's got a supportive friend who gives big hugs.
We know that pediatricians and other pediatric providers are uniquely situated to identify children who are at risk, and can, in turn, equip families with resources. And we created these resources with such providers in mind: What makes our tools so effective is that they can be integrated into any intervention or service, enlisting our lovable Muppets as guides. Watching Elmo or Big Bird talk about their emotions can provide comfort to children coping with big feelings of their own.

In one video called “Comfy Cozy Nest,” when Big Bird faces an unspecified difficult situation, he learns to think of his nest as a “safe space” with comforting items like his teddy bear and Granny Bird’s birdseed cookies. This is a place he can go in his imagination to make himself feel safe. In others, Elmo builds a blanket fort to feel secure and the Count teaches Cookie Monster a breathing strategy to help him relax.

In addition to engaging materials for children, providers can find professional development workshops, webinars, and other adult-facing content that includes, as part of our trauma content, a powerful animation to help parents and caregivers understand the impact of domestic violence from a child’s perspective.

Sesame Street Workshop
Dr. Jeanette Betancourt with Elmo
Our trauma content is part of Sesame Street in Communities, a first-of-its-kind initiative to help the pediatric community, providers, parents, and caregivers give children a strong and healthy start. Sesame Street in Communities offers hundreds of free, multimedia tools to help children as they grow through the critical developmental window of birth through age 6 years. In addition to our new resources around traumatic experiences, Sesame Street in Communities pulls together decades of content for providers and families around early math and literacy, healthy habits, food insecurity, handling emergencies, and more. All resources are available for free in English and Spanish at www.sesamestreetincommunities.org.

No one plays a more vital role in children’s health and well-being than pediatricians, nurse practitioners, and family physicians. Our hope is that Sesame Street in Communities will allow us to work together, to help children everywhere grow smarter, stronger, and kinder.

Dr. Betancourt is the senior vice president for U.S. social impact at Sesame Workshop, the nonprofit media and educational organization behind Sesame Street, in New York.

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Introducing the VA Boston Medical Forum

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The case history has been the cornerstone of clinical learning since the first record of medical encounters in ancient Egypt.1 The methodical process of taking a patient history by Hippocratic physicians enabled an empirical approach to medicine centuries before the scientific revolution. From Freud in psychiatry to Giovanni Morgagni in pathology—case reports have been the time-honored and time-tested vehicle for teaching medicine.2

Most American physicians grew up reading the most famous modern series of histories, the “Case Records of the Massachusetts General Hospital,” published in that pinnacle of medical scholarship, The New England Journal of Medicine. Now, also from Boston, I’m proud to announce that Federal Practitioner has its own case series, The VA Boston Medical Forum (HIV-Positive Veteran With Progressive Visual Changes, page 18).

The VA Boston Medical Forum is a printed (and electronic, these days) version of the case conferences held at the flagship VA Boston Healthcare System (VABHS), which has academic affiliations with the Boston Medical Center, Beth Israel Deaconess Medical Center, and Brigham and Women’s Hospital. Brian Hoffman, professor emeritus at Harvard Medical School, who previously served as the chief of internal medicine at the VABHS, founded the series, which has continued for more than 10 years.

The didactic driving force of this medical forum are the VABHS chief medical residents and their director of residency education. It is—as you will see in this issue—a case report taken from a weekly multidisciplinary conference. We feel the authors have captured much of the interactive ambience of those case conferences, including laboratory values, medical images, extensive references, and takeaway points, as though you were there at morning rounds.

Each case involves a VA patient and presents in traditional case history format a discussion of the diagnosis and treatment of a challenging patient. Just as they do at the actual case conferences, the chief medical residents moderate these discussions, which also feature expert opinions from nationally recognized leaders in their respective medical specialties.

From the many cases they present, the chief medical residents and their director of residency education will select cases that focus on clinical problems relevant to those caring for veterans, such as homelessness, comorbid substance use disorders, along with thought provoking and complex medical presentations that will test the clinical reasoning of the most experienced diagnostician.

Over many years as a medical educator, I have come to believe that whether it is ethics or surgery, we all learn best from an interesting case history and a good medical mystery. We hope to provide both in this conversational, question-and-answer format. Think back to your days on the wards: You can have all that intellectual stimulation without the night call and “pimping.” So from the comfort of your favorite reading spot, we invite you to sit back and enjoy. This is continuing medical education at its best, and I am proud to welcome our readers to the inaugural case of what we at Federal Practitioner hope will be an enduring feature. We thank the authors of the Boston Medical Forum for their dedication to enhancing VA academic medicine and, most important, helping us all to be smarter caregivers for our veterans.

References

1. Nissen T, Wynn R. The history of the case report: a selective review. JRSM Open. 2014;5(4): 2054270414523410.

2. Nuland SB. Doctors: The Biography of Medicine. New York: Alfred Knopf, 1988.

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The case history has been the cornerstone of clinical learning since the first record of medical encounters in ancient Egypt.1 The methodical process of taking a patient history by Hippocratic physicians enabled an empirical approach to medicine centuries before the scientific revolution. From Freud in psychiatry to Giovanni Morgagni in pathology—case reports have been the time-honored and time-tested vehicle for teaching medicine.2

Most American physicians grew up reading the most famous modern series of histories, the “Case Records of the Massachusetts General Hospital,” published in that pinnacle of medical scholarship, The New England Journal of Medicine. Now, also from Boston, I’m proud to announce that Federal Practitioner has its own case series, The VA Boston Medical Forum (HIV-Positive Veteran With Progressive Visual Changes, page 18).

The VA Boston Medical Forum is a printed (and electronic, these days) version of the case conferences held at the flagship VA Boston Healthcare System (VABHS), which has academic affiliations with the Boston Medical Center, Beth Israel Deaconess Medical Center, and Brigham and Women’s Hospital. Brian Hoffman, professor emeritus at Harvard Medical School, who previously served as the chief of internal medicine at the VABHS, founded the series, which has continued for more than 10 years.

The didactic driving force of this medical forum are the VABHS chief medical residents and their director of residency education. It is—as you will see in this issue—a case report taken from a weekly multidisciplinary conference. We feel the authors have captured much of the interactive ambience of those case conferences, including laboratory values, medical images, extensive references, and takeaway points, as though you were there at morning rounds.

Each case involves a VA patient and presents in traditional case history format a discussion of the diagnosis and treatment of a challenging patient. Just as they do at the actual case conferences, the chief medical residents moderate these discussions, which also feature expert opinions from nationally recognized leaders in their respective medical specialties.

From the many cases they present, the chief medical residents and their director of residency education will select cases that focus on clinical problems relevant to those caring for veterans, such as homelessness, comorbid substance use disorders, along with thought provoking and complex medical presentations that will test the clinical reasoning of the most experienced diagnostician.

Over many years as a medical educator, I have come to believe that whether it is ethics or surgery, we all learn best from an interesting case history and a good medical mystery. We hope to provide both in this conversational, question-and-answer format. Think back to your days on the wards: You can have all that intellectual stimulation without the night call and “pimping.” So from the comfort of your favorite reading spot, we invite you to sit back and enjoy. This is continuing medical education at its best, and I am proud to welcome our readers to the inaugural case of what we at Federal Practitioner hope will be an enduring feature. We thank the authors of the Boston Medical Forum for their dedication to enhancing VA academic medicine and, most important, helping us all to be smarter caregivers for our veterans.

The case history has been the cornerstone of clinical learning since the first record of medical encounters in ancient Egypt.1 The methodical process of taking a patient history by Hippocratic physicians enabled an empirical approach to medicine centuries before the scientific revolution. From Freud in psychiatry to Giovanni Morgagni in pathology—case reports have been the time-honored and time-tested vehicle for teaching medicine.2

Most American physicians grew up reading the most famous modern series of histories, the “Case Records of the Massachusetts General Hospital,” published in that pinnacle of medical scholarship, The New England Journal of Medicine. Now, also from Boston, I’m proud to announce that Federal Practitioner has its own case series, The VA Boston Medical Forum (HIV-Positive Veteran With Progressive Visual Changes, page 18).

The VA Boston Medical Forum is a printed (and electronic, these days) version of the case conferences held at the flagship VA Boston Healthcare System (VABHS), which has academic affiliations with the Boston Medical Center, Beth Israel Deaconess Medical Center, and Brigham and Women’s Hospital. Brian Hoffman, professor emeritus at Harvard Medical School, who previously served as the chief of internal medicine at the VABHS, founded the series, which has continued for more than 10 years.

The didactic driving force of this medical forum are the VABHS chief medical residents and their director of residency education. It is—as you will see in this issue—a case report taken from a weekly multidisciplinary conference. We feel the authors have captured much of the interactive ambience of those case conferences, including laboratory values, medical images, extensive references, and takeaway points, as though you were there at morning rounds.

Each case involves a VA patient and presents in traditional case history format a discussion of the diagnosis and treatment of a challenging patient. Just as they do at the actual case conferences, the chief medical residents moderate these discussions, which also feature expert opinions from nationally recognized leaders in their respective medical specialties.

From the many cases they present, the chief medical residents and their director of residency education will select cases that focus on clinical problems relevant to those caring for veterans, such as homelessness, comorbid substance use disorders, along with thought provoking and complex medical presentations that will test the clinical reasoning of the most experienced diagnostician.

Over many years as a medical educator, I have come to believe that whether it is ethics or surgery, we all learn best from an interesting case history and a good medical mystery. We hope to provide both in this conversational, question-and-answer format. Think back to your days on the wards: You can have all that intellectual stimulation without the night call and “pimping.” So from the comfort of your favorite reading spot, we invite you to sit back and enjoy. This is continuing medical education at its best, and I am proud to welcome our readers to the inaugural case of what we at Federal Practitioner hope will be an enduring feature. We thank the authors of the Boston Medical Forum for their dedication to enhancing VA academic medicine and, most important, helping us all to be smarter caregivers for our veterans.

References

1. Nissen T, Wynn R. The history of the case report: a selective review. JRSM Open. 2014;5(4): 2054270414523410.

2. Nuland SB. Doctors: The Biography of Medicine. New York: Alfred Knopf, 1988.

References

1. Nissen T, Wynn R. The history of the case report: a selective review. JRSM Open. 2014;5(4): 2054270414523410.

2. Nuland SB. Doctors: The Biography of Medicine. New York: Alfred Knopf, 1988.

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Listen carefully

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The widespread use of fetal ultrasound has dramatically decreased the number of delivery room surprises. In this country, most infants with a cardiac anomaly detected in utero probably are delivered at tertiary medical centers, leapfrogging over the maternity units at their local community hospitals. But infants with critical cardiac conditions continue to arrive unheralded at every hospital, both large and small. And many of these babies are asymptomatic without tachypnea or cyanosis. A study reported in the October 2017 Pediatrics by Hu et al. suggests a strategy for detecting these little masters of disguise before their lesions get them into serious trouble (doi: 10.1542/peds.2017-1154).

Pulse oximetry has been widely debated as a method for detecting congenital heart disease, because of course it misses the cases that are acyanotic. In a series of more than 150,000 asymptomatic neonates, these investigators combined cardiac auscultation with pulse oximetry and achieved a sensitivity of 96% in detecting critical congenital heart disease and 92% for major congenital heart disease. Their false-positive rate for both categories was just a bit over 1%.

Courtesy Dr. William G. Wilkoff
Dr. William G. Wilkoff
The abstract left me with several questions, because I wondered if there was something about the auscultation procedure they were using. The paper doesn’t describe the exact technique used or the timing, but it does say that the clinicians who did the auscultating were “highly trained” and closely supervised. And the procedure was performed in a “quiet environment.”

This may be another case in which the training of the examiner and the environment are critical to a positive result. As I think back to the conditions in which I examined newborns, I wonder how careful I was that my auscultating was being done in a quiet environment. If I was in the nursery, there may have been other babies crying, a radio playing, or nurses conversing with one another. I may have been deluding myself that, over the years in practice, I had developed the ability to cancel out those auditory distractions. It was probably dumb luck that I didn’t miss any critical murmurs.

And then there is the timing. The investigators don’t describe how soon after birth the auscultation was performed. Is there an optimum time in relation to the neonate’s transition from his/her fetal circulation? How long did the examiners listen? Were they in a rush to get back to their offices and busy waiting room or were they hospitalists?

I found this to be an interesting study, and if repeated by other investigators, it provides an example of how technology advancement doesn’t always render our old examining skills obsolete. In fact, it may demand we sharpen them.

Dr. Wilkoff practiced primary care pediatrics in Brunswick, Maine for nearly 40 years. He has authored several books on behavioral pediatrics, including “How to Say No to Your Toddler.” Email him at [email protected].

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The widespread use of fetal ultrasound has dramatically decreased the number of delivery room surprises. In this country, most infants with a cardiac anomaly detected in utero probably are delivered at tertiary medical centers, leapfrogging over the maternity units at their local community hospitals. But infants with critical cardiac conditions continue to arrive unheralded at every hospital, both large and small. And many of these babies are asymptomatic without tachypnea or cyanosis. A study reported in the October 2017 Pediatrics by Hu et al. suggests a strategy for detecting these little masters of disguise before their lesions get them into serious trouble (doi: 10.1542/peds.2017-1154).

Pulse oximetry has been widely debated as a method for detecting congenital heart disease, because of course it misses the cases that are acyanotic. In a series of more than 150,000 asymptomatic neonates, these investigators combined cardiac auscultation with pulse oximetry and achieved a sensitivity of 96% in detecting critical congenital heart disease and 92% for major congenital heart disease. Their false-positive rate for both categories was just a bit over 1%.

Courtesy Dr. William G. Wilkoff
Dr. William G. Wilkoff
The abstract left me with several questions, because I wondered if there was something about the auscultation procedure they were using. The paper doesn’t describe the exact technique used or the timing, but it does say that the clinicians who did the auscultating were “highly trained” and closely supervised. And the procedure was performed in a “quiet environment.”

This may be another case in which the training of the examiner and the environment are critical to a positive result. As I think back to the conditions in which I examined newborns, I wonder how careful I was that my auscultating was being done in a quiet environment. If I was in the nursery, there may have been other babies crying, a radio playing, or nurses conversing with one another. I may have been deluding myself that, over the years in practice, I had developed the ability to cancel out those auditory distractions. It was probably dumb luck that I didn’t miss any critical murmurs.

And then there is the timing. The investigators don’t describe how soon after birth the auscultation was performed. Is there an optimum time in relation to the neonate’s transition from his/her fetal circulation? How long did the examiners listen? Were they in a rush to get back to their offices and busy waiting room or were they hospitalists?

I found this to be an interesting study, and if repeated by other investigators, it provides an example of how technology advancement doesn’t always render our old examining skills obsolete. In fact, it may demand we sharpen them.

Dr. Wilkoff practiced primary care pediatrics in Brunswick, Maine for nearly 40 years. He has authored several books on behavioral pediatrics, including “How to Say No to Your Toddler.” Email him at [email protected].

 

The widespread use of fetal ultrasound has dramatically decreased the number of delivery room surprises. In this country, most infants with a cardiac anomaly detected in utero probably are delivered at tertiary medical centers, leapfrogging over the maternity units at their local community hospitals. But infants with critical cardiac conditions continue to arrive unheralded at every hospital, both large and small. And many of these babies are asymptomatic without tachypnea or cyanosis. A study reported in the October 2017 Pediatrics by Hu et al. suggests a strategy for detecting these little masters of disguise before their lesions get them into serious trouble (doi: 10.1542/peds.2017-1154).

Pulse oximetry has been widely debated as a method for detecting congenital heart disease, because of course it misses the cases that are acyanotic. In a series of more than 150,000 asymptomatic neonates, these investigators combined cardiac auscultation with pulse oximetry and achieved a sensitivity of 96% in detecting critical congenital heart disease and 92% for major congenital heart disease. Their false-positive rate for both categories was just a bit over 1%.

Courtesy Dr. William G. Wilkoff
Dr. William G. Wilkoff
The abstract left me with several questions, because I wondered if there was something about the auscultation procedure they were using. The paper doesn’t describe the exact technique used or the timing, but it does say that the clinicians who did the auscultating were “highly trained” and closely supervised. And the procedure was performed in a “quiet environment.”

This may be another case in which the training of the examiner and the environment are critical to a positive result. As I think back to the conditions in which I examined newborns, I wonder how careful I was that my auscultating was being done in a quiet environment. If I was in the nursery, there may have been other babies crying, a radio playing, or nurses conversing with one another. I may have been deluding myself that, over the years in practice, I had developed the ability to cancel out those auditory distractions. It was probably dumb luck that I didn’t miss any critical murmurs.

And then there is the timing. The investigators don’t describe how soon after birth the auscultation was performed. Is there an optimum time in relation to the neonate’s transition from his/her fetal circulation? How long did the examiners listen? Were they in a rush to get back to their offices and busy waiting room or were they hospitalists?

I found this to be an interesting study, and if repeated by other investigators, it provides an example of how technology advancement doesn’t always render our old examining skills obsolete. In fact, it may demand we sharpen them.

Dr. Wilkoff practiced primary care pediatrics in Brunswick, Maine for nearly 40 years. He has authored several books on behavioral pediatrics, including “How to Say No to Your Toddler.” Email him at [email protected].

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Guidelines are not cookbooks

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For many years I have counseled medical students and residents that half of what I was taught in medical school has since been proven obsolete or frankly wrong. I counsel them that I have no reason to believe that I am any better than my professors were. So I wish them luck sorting out what is true. Earlier in my career, that warning was mild hyperbole, but not anymore.

Upper respiratory infections (URIs) are the most common reason for an office visit during the winter. Bronchiolitis is the most frequent diagnosis for a winter admission of an infant to a community hospital. Pediatricians have nuanced assessments and many options when treating these diseases. Best practices have changed frequently over the past 3 decades, mostly by eliminating previously espoused treatments as ineffective. In infants and young children, those obsolete treatments include decongestants and cough suppressants for young children with common colds, inhaled beta-agonists and steroids for infants with bronchiolitis, and antibiotics for simple otitis media in older children. In other words, most of what I was originally taught.

copyright iStock/Thinkstock
My training, backed up by frequent experience when working as both a primary care provider and as a hospitalist, is that a significant fraction of infants after respiratory syncytial virus bronchiolitis will maintain twitchy airways for 3-6 months, during which time a simple URI seems to flare their albuterol-responsive lower respiratory tract wheezing, just as URIs do for asthmatics. This does not mean that their initial bronchiolitis was responsive to albuterol. I no longer use albuterol for initial episodes. Once fully healed, this cohort of young children has no further problem with wheezing. I therefore do not think they ever had asthma. This transient “reactive airways disease” is a manifestation of the healing time from bronchiolitis. This phenomenon is different from the statistic that one-third of children diagnosed with asthma as toddlers will outgrow it by age 5 years. This phenomenon has been somewhat supported by articles I have read, but never conclusively proven in a double blind, randomized controlled trial. My own experience vetting the phenomenon could be tainted by confirmation bias.

There is a discontinuity between guidelines that forbid routine steroids and beta-agonists for bronchiolitis in infants, and guidelines that strongly prescribe steroids, metered dose inhalers, and asthma action plans for all discharged wheezers over age 2 years. When I worked as a hospitalist in the pulmonology department, I frequently diagnosed asthma under age 1 year. As a general pediatric hospitalist, one winter I twice ran afoul of a hospital quality metric that benchmarked 100% compliance with providing steroids, inhaled corticosteroids, and asthma action plans on discharge for all wheezers over age 2. Fortunately for both me and the quality team working on that quality dashboard, my thorough documentation of why I didn’t think a particular wheezer had asthma was detailed enough to satisfy peer review.

Historically, medical knowledge has been dependent upon these types of observation which then are taught to the next generation of physicians and, if confirmed repeatedly, become memes with some degree of reliability. An all-too-typical Cochrane library entry may challenge these memes by looking at 200 articles, finding 20 relevant studies, selecting only 2 underpowered studies as meeting their randomized controlled trial criteria, and then concluding that there is “insufficient evidence” to prove the treatment works. But absence of proof is not proof of absence. Twenty five years after coining the phrase “evidence-based medicine,” our medical knowledge base has not been purified.

Dr. Kevin T. Powell
In the 17th century, French philosopher Rene Descartes concluded that too much of what he had been taught was wrong. He tried to purify his knowledge by starting over and only trusting what he could deduce with absolute certainty. His first deduction was “I think, therefore I am.”

In medicine, absolute certainty isn’t possible. Using 95% confidence intervals for a research paper does not even mean it is 95% likely to be right. So part of the art of medicine is finding a balance between cookbook guidelines (which might not fit a particular patient) and personal experience (which is tainted with confirmation bias.) It is a very imperfect art.
 

Dr. Powell is a pediatric hospitalist and clinical ethics consultant living in St. Louis. Email him at [email protected].

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For many years I have counseled medical students and residents that half of what I was taught in medical school has since been proven obsolete or frankly wrong. I counsel them that I have no reason to believe that I am any better than my professors were. So I wish them luck sorting out what is true. Earlier in my career, that warning was mild hyperbole, but not anymore.

Upper respiratory infections (URIs) are the most common reason for an office visit during the winter. Bronchiolitis is the most frequent diagnosis for a winter admission of an infant to a community hospital. Pediatricians have nuanced assessments and many options when treating these diseases. Best practices have changed frequently over the past 3 decades, mostly by eliminating previously espoused treatments as ineffective. In infants and young children, those obsolete treatments include decongestants and cough suppressants for young children with common colds, inhaled beta-agonists and steroids for infants with bronchiolitis, and antibiotics for simple otitis media in older children. In other words, most of what I was originally taught.

copyright iStock/Thinkstock
My training, backed up by frequent experience when working as both a primary care provider and as a hospitalist, is that a significant fraction of infants after respiratory syncytial virus bronchiolitis will maintain twitchy airways for 3-6 months, during which time a simple URI seems to flare their albuterol-responsive lower respiratory tract wheezing, just as URIs do for asthmatics. This does not mean that their initial bronchiolitis was responsive to albuterol. I no longer use albuterol for initial episodes. Once fully healed, this cohort of young children has no further problem with wheezing. I therefore do not think they ever had asthma. This transient “reactive airways disease” is a manifestation of the healing time from bronchiolitis. This phenomenon is different from the statistic that one-third of children diagnosed with asthma as toddlers will outgrow it by age 5 years. This phenomenon has been somewhat supported by articles I have read, but never conclusively proven in a double blind, randomized controlled trial. My own experience vetting the phenomenon could be tainted by confirmation bias.

There is a discontinuity between guidelines that forbid routine steroids and beta-agonists for bronchiolitis in infants, and guidelines that strongly prescribe steroids, metered dose inhalers, and asthma action plans for all discharged wheezers over age 2 years. When I worked as a hospitalist in the pulmonology department, I frequently diagnosed asthma under age 1 year. As a general pediatric hospitalist, one winter I twice ran afoul of a hospital quality metric that benchmarked 100% compliance with providing steroids, inhaled corticosteroids, and asthma action plans on discharge for all wheezers over age 2. Fortunately for both me and the quality team working on that quality dashboard, my thorough documentation of why I didn’t think a particular wheezer had asthma was detailed enough to satisfy peer review.

Historically, medical knowledge has been dependent upon these types of observation which then are taught to the next generation of physicians and, if confirmed repeatedly, become memes with some degree of reliability. An all-too-typical Cochrane library entry may challenge these memes by looking at 200 articles, finding 20 relevant studies, selecting only 2 underpowered studies as meeting their randomized controlled trial criteria, and then concluding that there is “insufficient evidence” to prove the treatment works. But absence of proof is not proof of absence. Twenty five years after coining the phrase “evidence-based medicine,” our medical knowledge base has not been purified.

Dr. Kevin T. Powell
In the 17th century, French philosopher Rene Descartes concluded that too much of what he had been taught was wrong. He tried to purify his knowledge by starting over and only trusting what he could deduce with absolute certainty. His first deduction was “I think, therefore I am.”

In medicine, absolute certainty isn’t possible. Using 95% confidence intervals for a research paper does not even mean it is 95% likely to be right. So part of the art of medicine is finding a balance between cookbook guidelines (which might not fit a particular patient) and personal experience (which is tainted with confirmation bias.) It is a very imperfect art.
 

Dr. Powell is a pediatric hospitalist and clinical ethics consultant living in St. Louis. Email him at [email protected].

 

For many years I have counseled medical students and residents that half of what I was taught in medical school has since been proven obsolete or frankly wrong. I counsel them that I have no reason to believe that I am any better than my professors were. So I wish them luck sorting out what is true. Earlier in my career, that warning was mild hyperbole, but not anymore.

Upper respiratory infections (URIs) are the most common reason for an office visit during the winter. Bronchiolitis is the most frequent diagnosis for a winter admission of an infant to a community hospital. Pediatricians have nuanced assessments and many options when treating these diseases. Best practices have changed frequently over the past 3 decades, mostly by eliminating previously espoused treatments as ineffective. In infants and young children, those obsolete treatments include decongestants and cough suppressants for young children with common colds, inhaled beta-agonists and steroids for infants with bronchiolitis, and antibiotics for simple otitis media in older children. In other words, most of what I was originally taught.

copyright iStock/Thinkstock
My training, backed up by frequent experience when working as both a primary care provider and as a hospitalist, is that a significant fraction of infants after respiratory syncytial virus bronchiolitis will maintain twitchy airways for 3-6 months, during which time a simple URI seems to flare their albuterol-responsive lower respiratory tract wheezing, just as URIs do for asthmatics. This does not mean that their initial bronchiolitis was responsive to albuterol. I no longer use albuterol for initial episodes. Once fully healed, this cohort of young children has no further problem with wheezing. I therefore do not think they ever had asthma. This transient “reactive airways disease” is a manifestation of the healing time from bronchiolitis. This phenomenon is different from the statistic that one-third of children diagnosed with asthma as toddlers will outgrow it by age 5 years. This phenomenon has been somewhat supported by articles I have read, but never conclusively proven in a double blind, randomized controlled trial. My own experience vetting the phenomenon could be tainted by confirmation bias.

There is a discontinuity between guidelines that forbid routine steroids and beta-agonists for bronchiolitis in infants, and guidelines that strongly prescribe steroids, metered dose inhalers, and asthma action plans for all discharged wheezers over age 2 years. When I worked as a hospitalist in the pulmonology department, I frequently diagnosed asthma under age 1 year. As a general pediatric hospitalist, one winter I twice ran afoul of a hospital quality metric that benchmarked 100% compliance with providing steroids, inhaled corticosteroids, and asthma action plans on discharge for all wheezers over age 2. Fortunately for both me and the quality team working on that quality dashboard, my thorough documentation of why I didn’t think a particular wheezer had asthma was detailed enough to satisfy peer review.

Historically, medical knowledge has been dependent upon these types of observation which then are taught to the next generation of physicians and, if confirmed repeatedly, become memes with some degree of reliability. An all-too-typical Cochrane library entry may challenge these memes by looking at 200 articles, finding 20 relevant studies, selecting only 2 underpowered studies as meeting their randomized controlled trial criteria, and then concluding that there is “insufficient evidence” to prove the treatment works. But absence of proof is not proof of absence. Twenty five years after coining the phrase “evidence-based medicine,” our medical knowledge base has not been purified.

Dr. Kevin T. Powell
In the 17th century, French philosopher Rene Descartes concluded that too much of what he had been taught was wrong. He tried to purify his knowledge by starting over and only trusting what he could deduce with absolute certainty. His first deduction was “I think, therefore I am.”

In medicine, absolute certainty isn’t possible. Using 95% confidence intervals for a research paper does not even mean it is 95% likely to be right. So part of the art of medicine is finding a balance between cookbook guidelines (which might not fit a particular patient) and personal experience (which is tainted with confirmation bias.) It is a very imperfect art.
 

Dr. Powell is a pediatric hospitalist and clinical ethics consultant living in St. Louis. Email him at [email protected].

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Vaccine renaissance

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In 1967, pediatric patients were vaccinated routinely against eight diseases with 10 vaccines: smallpox; diphtheria; tetanus and pertussis; polio serotypes 1, 2, and 3; measles; rubella; and mumps. Then in 1989, vaccine discovery took a dramatic upward trend. For the physicians and scientists involved in vaccine discovery, the driving force may have been a passion for scientific discovery and a humanitarian motivation, but what drove this major change in pediatric infectious diseases was economics.

KatarzynaBialasiewicz/Thinkstock
In 1989, I was fortunate to be part of the discovery team of the Haemophilus influenzae type b (Hib) polysaccharide and conjugate vaccines developed in Rochester, N.Y. Our team was led by David H. Smith, MD, and Porter Anderson, PhD – who later won the Lasker Prize for the significance of their work. Another team of scientists working at the National Institutes of Health was led by John Robbins, MD, and Rachel Schneerson, MD, where they concurrently developed a Hib conjugate vaccine using a different protein carrier and conjugation technology – they shared the Lasker Prize equally with Dr. Smith and Dr. Anderson.

I believe it was the success of the Hib conjugate vaccine that led to a renaissance in vaccine discovery that followed and continues to grow every year. The hiatus of more than 20 years between the introduction of the mumps vaccine in 1967 and that of the Hib vaccine in 1989 in my view was because the economic incentives to develop vaccines were absent. In fact, in the 1970s and early 1980s, vaccine manufacturers were drawing back from making vaccines because they were losing money selling them at a few dollars per dose.

Importantly, when the Hib conjugate vaccine was ready to be released, it had an unprecedented $15 per dose price. What followed was a big surprise to major pharmaceutical and vaccine companies: The Centers for Disease Control and Prevention and the American Academy of Pediatrics endorsed the use of the vaccine as routine. Private insurance companies were obliged to pay for vaccines as part of well-child care, and sales of the product proved profitable.

A trailblazing path had been created, and more and more vaccines have been discovered and come to market since then. Combination vaccines and vaccines for adolescents and adults have followed. The biggest blockbuster is Prevnar13 (actually 13 vaccines contained in a single combination), now with annual sales in excess of $7 billion worldwide and growing. Other vaccines with sales of a billion dollars or more are also on the market; anything in excess of $1 billion is considered a blockbuster in the pharmaceutical industry and gets the attention of CEOs (and investors) in a big way.

Dr. Michael E. Pichichero
So now we have multiple large vaccine companies worldwide, and many smaller start-up vaccine companies as well. We have seen the introduction of vaccines in which not only infectious diseases are the target, but also more cancer prevention vaccines are coming to follow hepatitis B and human papillomavirus vaccines. Vaccines for other disease states – including autoimmune diseases, allergies, cardiovascular disease, diabetes, and many others – are in development. To me, this has been the most remarkable achievement of the past 50 years.
 

 

 

Dr. Pichichero, a specialist in pediatric infectious diseases, is director of the Research Institute at Rochester (N.Y.) General Hospital. He is also a pediatrician at Legacy Pediatrics in Rochester. He has received funding awarded to his institution for vaccine research from GlaxoSmithKline, Merck, Pfizer, and Sanofi Pasteur. Email him at [email protected].

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In 1967, pediatric patients were vaccinated routinely against eight diseases with 10 vaccines: smallpox; diphtheria; tetanus and pertussis; polio serotypes 1, 2, and 3; measles; rubella; and mumps. Then in 1989, vaccine discovery took a dramatic upward trend. For the physicians and scientists involved in vaccine discovery, the driving force may have been a passion for scientific discovery and a humanitarian motivation, but what drove this major change in pediatric infectious diseases was economics.

KatarzynaBialasiewicz/Thinkstock
In 1989, I was fortunate to be part of the discovery team of the Haemophilus influenzae type b (Hib) polysaccharide and conjugate vaccines developed in Rochester, N.Y. Our team was led by David H. Smith, MD, and Porter Anderson, PhD – who later won the Lasker Prize for the significance of their work. Another team of scientists working at the National Institutes of Health was led by John Robbins, MD, and Rachel Schneerson, MD, where they concurrently developed a Hib conjugate vaccine using a different protein carrier and conjugation technology – they shared the Lasker Prize equally with Dr. Smith and Dr. Anderson.

I believe it was the success of the Hib conjugate vaccine that led to a renaissance in vaccine discovery that followed and continues to grow every year. The hiatus of more than 20 years between the introduction of the mumps vaccine in 1967 and that of the Hib vaccine in 1989 in my view was because the economic incentives to develop vaccines were absent. In fact, in the 1970s and early 1980s, vaccine manufacturers were drawing back from making vaccines because they were losing money selling them at a few dollars per dose.

Importantly, when the Hib conjugate vaccine was ready to be released, it had an unprecedented $15 per dose price. What followed was a big surprise to major pharmaceutical and vaccine companies: The Centers for Disease Control and Prevention and the American Academy of Pediatrics endorsed the use of the vaccine as routine. Private insurance companies were obliged to pay for vaccines as part of well-child care, and sales of the product proved profitable.

A trailblazing path had been created, and more and more vaccines have been discovered and come to market since then. Combination vaccines and vaccines for adolescents and adults have followed. The biggest blockbuster is Prevnar13 (actually 13 vaccines contained in a single combination), now with annual sales in excess of $7 billion worldwide and growing. Other vaccines with sales of a billion dollars or more are also on the market; anything in excess of $1 billion is considered a blockbuster in the pharmaceutical industry and gets the attention of CEOs (and investors) in a big way.

Dr. Michael E. Pichichero
So now we have multiple large vaccine companies worldwide, and many smaller start-up vaccine companies as well. We have seen the introduction of vaccines in which not only infectious diseases are the target, but also more cancer prevention vaccines are coming to follow hepatitis B and human papillomavirus vaccines. Vaccines for other disease states – including autoimmune diseases, allergies, cardiovascular disease, diabetes, and many others – are in development. To me, this has been the most remarkable achievement of the past 50 years.
 

 

 

Dr. Pichichero, a specialist in pediatric infectious diseases, is director of the Research Institute at Rochester (N.Y.) General Hospital. He is also a pediatrician at Legacy Pediatrics in Rochester. He has received funding awarded to his institution for vaccine research from GlaxoSmithKline, Merck, Pfizer, and Sanofi Pasteur. Email him at [email protected].

 

In 1967, pediatric patients were vaccinated routinely against eight diseases with 10 vaccines: smallpox; diphtheria; tetanus and pertussis; polio serotypes 1, 2, and 3; measles; rubella; and mumps. Then in 1989, vaccine discovery took a dramatic upward trend. For the physicians and scientists involved in vaccine discovery, the driving force may have been a passion for scientific discovery and a humanitarian motivation, but what drove this major change in pediatric infectious diseases was economics.

KatarzynaBialasiewicz/Thinkstock
In 1989, I was fortunate to be part of the discovery team of the Haemophilus influenzae type b (Hib) polysaccharide and conjugate vaccines developed in Rochester, N.Y. Our team was led by David H. Smith, MD, and Porter Anderson, PhD – who later won the Lasker Prize for the significance of their work. Another team of scientists working at the National Institutes of Health was led by John Robbins, MD, and Rachel Schneerson, MD, where they concurrently developed a Hib conjugate vaccine using a different protein carrier and conjugation technology – they shared the Lasker Prize equally with Dr. Smith and Dr. Anderson.

I believe it was the success of the Hib conjugate vaccine that led to a renaissance in vaccine discovery that followed and continues to grow every year. The hiatus of more than 20 years between the introduction of the mumps vaccine in 1967 and that of the Hib vaccine in 1989 in my view was because the economic incentives to develop vaccines were absent. In fact, in the 1970s and early 1980s, vaccine manufacturers were drawing back from making vaccines because they were losing money selling them at a few dollars per dose.

Importantly, when the Hib conjugate vaccine was ready to be released, it had an unprecedented $15 per dose price. What followed was a big surprise to major pharmaceutical and vaccine companies: The Centers for Disease Control and Prevention and the American Academy of Pediatrics endorsed the use of the vaccine as routine. Private insurance companies were obliged to pay for vaccines as part of well-child care, and sales of the product proved profitable.

A trailblazing path had been created, and more and more vaccines have been discovered and come to market since then. Combination vaccines and vaccines for adolescents and adults have followed. The biggest blockbuster is Prevnar13 (actually 13 vaccines contained in a single combination), now with annual sales in excess of $7 billion worldwide and growing. Other vaccines with sales of a billion dollars or more are also on the market; anything in excess of $1 billion is considered a blockbuster in the pharmaceutical industry and gets the attention of CEOs (and investors) in a big way.

Dr. Michael E. Pichichero
So now we have multiple large vaccine companies worldwide, and many smaller start-up vaccine companies as well. We have seen the introduction of vaccines in which not only infectious diseases are the target, but also more cancer prevention vaccines are coming to follow hepatitis B and human papillomavirus vaccines. Vaccines for other disease states – including autoimmune diseases, allergies, cardiovascular disease, diabetes, and many others – are in development. To me, this has been the most remarkable achievement of the past 50 years.
 

 

 

Dr. Pichichero, a specialist in pediatric infectious diseases, is director of the Research Institute at Rochester (N.Y.) General Hospital. He is also a pediatrician at Legacy Pediatrics in Rochester. He has received funding awarded to his institution for vaccine research from GlaxoSmithKline, Merck, Pfizer, and Sanofi Pasteur. Email him at [email protected].

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