Patients with atherosclerosis are at a greater risk of osteoporosis, and a recent study published in the American Journal of Physiology—Endocrinology and Metabolism explores how the development of atherosclerosis might encourage osteoporosis.

Researchers used mice to investigate the impact of oxidized lipids on bone homeostasis and to search for underlying pathogenic pathways.

Mice fed a high-fat diet for 3 months showed increased levels of oxidized lipids in bone, and decreased femoral and vertebral trabecular and cortical bone mass, compared with mice on a normal diet.

Researchers also found that atherosclerotic mice had fewer osteoblasts. While osteoclasts numbers decreased modestly in some bones, there were significantly more osteoclasts than osteoblasts overall, favoring bone loss. The researchers also observed that atherosclerosis-induced inflammation in the bone interfered with the maturation of new osteoblast cells, which accounted for the reduction in number of osteoblasts.

Patients with atherosclerosis are at a greater risk of osteoporosis, and a recent study published in the American Journal of Physiology—Endocrinology and Metabolism explores how the development of atherosclerosis might encourage osteoporosis.

Researchers used mice to investigate the impact of oxidized lipids on bone homeostasis and to search for underlying pathogenic pathways.

Mice fed a high-fat diet for 3 months showed increased levels of oxidized lipids in bone, and decreased femoral and vertebral trabecular and cortical bone mass, compared with mice on a normal diet.

Researchers also found that atherosclerotic mice had fewer osteoblasts. While osteoclasts numbers decreased modestly in some bones, there were significantly more osteoclasts than osteoblasts overall, favoring bone loss. The researchers also observed that atherosclerosis-induced inflammation in the bone interfered with the maturation of new osteoblast cells, which accounted for the reduction in number of osteoblasts.

Patients with atherosclerosis are at a greater risk of osteoporosis, and a recent study published in the American Journal of Physiology—Endocrinology and Metabolism explores how the development of atherosclerosis might encourage osteoporosis.

Researchers used mice to investigate the impact of oxidized lipids on bone homeostasis and to search for underlying pathogenic pathways.

Mice fed a high-fat diet for 3 months showed increased levels of oxidized lipids in bone, and decreased femoral and vertebral trabecular and cortical bone mass, compared with mice on a normal diet.

Researchers also found that atherosclerotic mice had fewer osteoblasts. While osteoclasts numbers decreased modestly in some bones, there were significantly more osteoclasts than osteoblasts overall, favoring bone loss. The researchers also observed that atherosclerosis-induced inflammation in the bone interfered with the maturation of new osteoblast cells, which accounted for the reduction in number of osteoblasts.

PARIS – Advances in CT scanner technology make cardiac CT a viable alternative to transesophageal echocardiography for preprocedural detection of left atrial appendage thrombus in candidates for transcatheter aortic valve replacement, Dr. Paul D. Williams said at the annual congress of the European Association of Percutaneous Cardiovascular Interventions.

This strategy helps simplify transcatheter aortic valve replacement (TAVR). That has become a major goal for the field now that TAVR’s safety and effectiveness have been established, said Dr. Williams of James Cook University Hospital in Middlesbrough, England.

“With the use of CT as the preferred method for annular sizing prior to the procedure and the increasing use of conscious sedation, transesophageal echo can be avoided altogether in many patients. And identification of left atrial appendage thrombus [LAAT] on CT may lead to changes in management, including optimization of oral anticoagulation, the use of an embolic protection device, and possibly obtaining consent from patients for a higher risk of procedural stroke,” he added.

Transesophageal echocardiography (TEE) has long been considered the gold standard method for detecting LAAT. But it has several disadvantages: It’s invasive, requires heavy sedation, and poses a small risk of serious complications.

Dr. Williams presented a single-center prospective study involving 198 consecutive patients who underwent dual source CT scanning with retrospective gated acquisition and flash angiographic acquisition during their pre-TAVR workup. The study showed that atrial fibrillation (AF) is very common in TAVR candidates, that LAAT is far more common in the TAVR population with AF than in the general AF population, and that while TAVR can still be performed in patients with LAAT, the periprocedural stroke risk appears to be higher.

Of the 198 TAVR candidates, 32% had AF. Two independent cardiologists with CT expertise rated 11.1% of TAVR candidates as having definite LAAT on the basis of a filling defect in both phases of imaging. Another 83.8% were deemed to definitely not have LAAT, while in 5.1% of cases the CT image quality wasn’t sufficient to render a judgment.

“The literature would suggest only about 5% of patients in the general AF population have LAAT. The rate is much higher in a TAVR population,” the cardiologist observed.

As expected, AF was a strong predictor of LAAT being found on CT, with a 32% prevalence in the AF subgroup, compared with just 1.6% in patients without AF.

Ninety-eight patients with a diagnostic CT also had a TEE. Six of the eight with LAAT on CT also showed LAAT on TEE. Two patients had LAAT on CT but not TEE. Thus, CT had 100% sensitivity, 97.8% specificity, a 75% positive predictive value, and a 100% negative predictive value, Dr. Williams continued.

Of the 198 patients evaluated by CT, 124 actually underwent TAVR. AF was present in 34% of these patients, whose mean CHA₂DS₂-VASc score was 3.7. CT showed that 8.1% of the patients who had TAVR had definite LAAT, and 84.7% definitely did not.

Six of the 124 patients (4.8%) had a stroke during their hospital stay for TAVR. Two of the six had LAAT on their preprocedural CT; both were being anticoagulated with warfarin at the time. The other four patients with periprocedural stroke didn’t have AF, were negative for LAAT on preprocedural CT, and weren’t being anticoagulated.

“Importantly, in the overall TAVR cohort, 8 of the 10 patients with LAAT on CT did not have a clinically evident periprocedural stroke,” Dr. Williams noted.

Session chair Dr. Rajendra Makkar, director of interventional cardiology at the Cedars-Sinai Heart Institute in Los Angeles, commented, “Your study has very, very important implications for how we actually change the management of some of our patients. You’ve shown LAAT is much more important in TAVR patients than I’d thought. A stroke risk of 20% with LAAT versus 3.8% in patients without LAAT is an impressive difference.”

His take away lesson from the study, Dr. Makkar added, is that if a patient has a preprocedural CT scan that’s negative for LAAT, there’s no need to do a TEE. If CT is positive or nondefinitive, it makes sense to review the patient’s anticoagulation regimen, then bring the patient back a few weeks later for a TEE to see if the LAAT has resolved.

Dr. Williams replied that’s exactly the practice now being followed at his hospital. If CT shows LAAT in a patient with AF who’s already on warfarin, physicians will consider aiming for a higher target INR [international normalized ratio], or they’ll switch to one of the novel oral anticoagulants if there’s a warfarin compliance issue. Then they’ll bring the patient back for a TEE.

“If the TEE is positive for LAAT we will still offer them TAVR, with the use of an embolic protection device if the anatomy is suitable, but we will tell them that potentially they may be at higher risk of stroke,” Dr. Williams said.

He reported having no financial conflicts of interest regarding this study.

[email protected]

PARIS – Advances in CT scanner technology make cardiac CT a viable alternative to transesophageal echocardiography for preprocedural detection of left atrial appendage thrombus in candidates for transcatheter aortic valve replacement, Dr. Paul D. Williams said at the annual congress of the European Association of Percutaneous Cardiovascular Interventions.

This strategy helps simplify transcatheter aortic valve replacement (TAVR). That has become a major goal for the field now that TAVR’s safety and effectiveness have been established, said Dr. Williams of James Cook University Hospital in Middlesbrough, England.

“With the use of CT as the preferred method for annular sizing prior to the procedure and the increasing use of conscious sedation, transesophageal echo can be avoided altogether in many patients. And identification of left atrial appendage thrombus [LAAT] on CT may lead to changes in management, including optimization of oral anticoagulation, the use of an embolic protection device, and possibly obtaining consent from patients for a higher risk of procedural stroke,” he added.

Transesophageal echocardiography (TEE) has long been considered the gold standard method for detecting LAAT. But it has several disadvantages: It’s invasive, requires heavy sedation, and poses a small risk of serious complications.

Dr. Williams presented a single-center prospective study involving 198 consecutive patients who underwent dual source CT scanning with retrospective gated acquisition and flash angiographic acquisition during their pre-TAVR workup. The study showed that atrial fibrillation (AF) is very common in TAVR candidates, that LAAT is far more common in the TAVR population with AF than in the general AF population, and that while TAVR can still be performed in patients with LAAT, the periprocedural stroke risk appears to be higher.

Of the 198 TAVR candidates, 32% had AF. Two independent cardiologists with CT expertise rated 11.1% of TAVR candidates as having definite LAAT on the basis of a filling defect in both phases of imaging. Another 83.8% were deemed to definitely not have LAAT, while in 5.1% of cases the CT image quality wasn’t sufficient to render a judgment.

“The literature would suggest only about 5% of patients in the general AF population have LAAT. The rate is much higher in a TAVR population,” the cardiologist observed.

As expected, AF was a strong predictor of LAAT being found on CT, with a 32% prevalence in the AF subgroup, compared with just 1.6% in patients without AF.

Ninety-eight patients with a diagnostic CT also had a TEE. Six of the eight with LAAT on CT also showed LAAT on TEE. Two patients had LAAT on CT but not TEE. Thus, CT had 100% sensitivity, 97.8% specificity, a 75% positive predictive value, and a 100% negative predictive value, Dr. Williams continued.

Of the 198 patients evaluated by CT, 124 actually underwent TAVR. AF was present in 34% of these patients, whose mean CHA₂DS₂-VASc score was 3.7. CT showed that 8.1% of the patients who had TAVR had definite LAAT, and 84.7% definitely did not.

Six of the 124 patients (4.8%) had a stroke during their hospital stay for TAVR. Two of the six had LAAT on their preprocedural CT; both were being anticoagulated with warfarin at the time. The other four patients with periprocedural stroke didn’t have AF, were negative for LAAT on preprocedural CT, and weren’t being anticoagulated.

“Importantly, in the overall TAVR cohort, 8 of the 10 patients with LAAT on CT did not have a clinically evident periprocedural stroke,” Dr. Williams noted.

Session chair Dr. Rajendra Makkar, director of interventional cardiology at the Cedars-Sinai Heart Institute in Los Angeles, commented, “Your study has very, very important implications for how we actually change the management of some of our patients. You’ve shown LAAT is much more important in TAVR patients than I’d thought. A stroke risk of 20% with LAAT versus 3.8% in patients without LAAT is an impressive difference.”

His take away lesson from the study, Dr. Makkar added, is that if a patient has a preprocedural CT scan that’s negative for LAAT, there’s no need to do a TEE. If CT is positive or nondefinitive, it makes sense to review the patient’s anticoagulation regimen, then bring the patient back a few weeks later for a TEE to see if the LAAT has resolved.

Dr. Williams replied that’s exactly the practice now being followed at his hospital. If CT shows LAAT in a patient with AF who’s already on warfarin, physicians will consider aiming for a higher target INR [international normalized ratio], or they’ll switch to one of the novel oral anticoagulants if there’s a warfarin compliance issue. Then they’ll bring the patient back for a TEE.

“If the TEE is positive for LAAT we will still offer them TAVR, with the use of an embolic protection device if the anatomy is suitable, but we will tell them that potentially they may be at higher risk of stroke,” Dr. Williams said.

He reported having no financial conflicts of interest regarding this study.

[email protected]

PARIS – Advances in CT scanner technology make cardiac CT a viable alternative to transesophageal echocardiography for preprocedural detection of left atrial appendage thrombus in candidates for transcatheter aortic valve replacement, Dr. Paul D. Williams said at the annual congress of the European Association of Percutaneous Cardiovascular Interventions.

This strategy helps simplify transcatheter aortic valve replacement (TAVR). That has become a major goal for the field now that TAVR’s safety and effectiveness have been established, said Dr. Williams of James Cook University Hospital in Middlesbrough, England.

“With the use of CT as the preferred method for annular sizing prior to the procedure and the increasing use of conscious sedation, transesophageal echo can be avoided altogether in many patients. And identification of left atrial appendage thrombus [LAAT] on CT may lead to changes in management, including optimization of oral anticoagulation, the use of an embolic protection device, and possibly obtaining consent from patients for a higher risk of procedural stroke,” he added.

Transesophageal echocardiography (TEE) has long been considered the gold standard method for detecting LAAT. But it has several disadvantages: It’s invasive, requires heavy sedation, and poses a small risk of serious complications.

Dr. Williams presented a single-center prospective study involving 198 consecutive patients who underwent dual source CT scanning with retrospective gated acquisition and flash angiographic acquisition during their pre-TAVR workup. The study showed that atrial fibrillation (AF) is very common in TAVR candidates, that LAAT is far more common in the TAVR population with AF than in the general AF population, and that while TAVR can still be performed in patients with LAAT, the periprocedural stroke risk appears to be higher.

Of the 198 TAVR candidates, 32% had AF. Two independent cardiologists with CT expertise rated 11.1% of TAVR candidates as having definite LAAT on the basis of a filling defect in both phases of imaging. Another 83.8% were deemed to definitely not have LAAT, while in 5.1% of cases the CT image quality wasn’t sufficient to render a judgment.

“The literature would suggest only about 5% of patients in the general AF population have LAAT. The rate is much higher in a TAVR population,” the cardiologist observed.

As expected, AF was a strong predictor of LAAT being found on CT, with a 32% prevalence in the AF subgroup, compared with just 1.6% in patients without AF.

Ninety-eight patients with a diagnostic CT also had a TEE. Six of the eight with LAAT on CT also showed LAAT on TEE. Two patients had LAAT on CT but not TEE. Thus, CT had 100% sensitivity, 97.8% specificity, a 75% positive predictive value, and a 100% negative predictive value, Dr. Williams continued.

Of the 198 patients evaluated by CT, 124 actually underwent TAVR. AF was present in 34% of these patients, whose mean CHA₂DS₂-VASc score was 3.7. CT showed that 8.1% of the patients who had TAVR had definite LAAT, and 84.7% definitely did not.

Six of the 124 patients (4.8%) had a stroke during their hospital stay for TAVR. Two of the six had LAAT on their preprocedural CT; both were being anticoagulated with warfarin at the time. The other four patients with periprocedural stroke didn’t have AF, were negative for LAAT on preprocedural CT, and weren’t being anticoagulated.

“Importantly, in the overall TAVR cohort, 8 of the 10 patients with LAAT on CT did not have a clinically evident periprocedural stroke,” Dr. Williams noted.

Session chair Dr. Rajendra Makkar, director of interventional cardiology at the Cedars-Sinai Heart Institute in Los Angeles, commented, “Your study has very, very important implications for how we actually change the management of some of our patients. You’ve shown LAAT is much more important in TAVR patients than I’d thought. A stroke risk of 20% with LAAT versus 3.8% in patients without LAAT is an impressive difference.”

His take away lesson from the study, Dr. Makkar added, is that if a patient has a preprocedural CT scan that’s negative for LAAT, there’s no need to do a TEE. If CT is positive or nondefinitive, it makes sense to review the patient’s anticoagulation regimen, then bring the patient back a few weeks later for a TEE to see if the LAAT has resolved.

Dr. Williams replied that’s exactly the practice now being followed at his hospital. If CT shows LAAT in a patient with AF who’s already on warfarin, physicians will consider aiming for a higher target INR [international normalized ratio], or they’ll switch to one of the novel oral anticoagulants if there’s a warfarin compliance issue. Then they’ll bring the patient back for a TEE.

“If the TEE is positive for LAAT we will still offer them TAVR, with the use of an embolic protection device if the anatomy is suitable, but we will tell them that potentially they may be at higher risk of stroke,” Dr. Williams said.

He reported having no financial conflicts of interest regarding this study.

[email protected]

Patients who receive a peripheral nerve block during hip or knee replacement surgery are less likely to experience complications, according to a recent large retrospective study.

Researchers reviewed more than 1 million hip and knee replacements performed between 2006 and 2013 using data from approximately 3,000 hospitals in the United States.

Investigators compiled information on cardiac, pulmonary, gastrointestinal, and renal complications. They also determined the rate of infections, wound complications, and inpatient falls. In addition, they analyzed data on resource utilization, which included the number of blood transfusions needed, admission to an intensive care unit, opioid consumption, length of hospital stay, and the cost of hospitalization.

They looked at data for 342,726 patients who had hip replacement surgery and 719,426 who had knee replacement surgery.

Overall, 18% of the patients received a peripheral nerve block. They found the rate peripheral nerve block use among patients with knee replacement increased from 15.2% in 2006 to 24.5% in 2013. The use of peripheral nerve blocks was associated with significantly lower odds for almost all complications.

A strong effect was seen for cardiac complications in patients with knee replacement and for wound complications in people who had hip replacement. Similar patterns were observed for resource utilization, particularly in length of hospital stay among patients with hip replacement.

Patients who receive a peripheral nerve block during hip or knee replacement surgery are less likely to experience complications, according to a recent large retrospective study.

Researchers reviewed more than 1 million hip and knee replacements performed between 2006 and 2013 using data from approximately 3,000 hospitals in the United States.

Investigators compiled information on cardiac, pulmonary, gastrointestinal, and renal complications. They also determined the rate of infections, wound complications, and inpatient falls. In addition, they analyzed data on resource utilization, which included the number of blood transfusions needed, admission to an intensive care unit, opioid consumption, length of hospital stay, and the cost of hospitalization.

They looked at data for 342,726 patients who had hip replacement surgery and 719,426 who had knee replacement surgery.

Overall, 18% of the patients received a peripheral nerve block. They found the rate peripheral nerve block use among patients with knee replacement increased from 15.2% in 2006 to 24.5% in 2013. The use of peripheral nerve blocks was associated with significantly lower odds for almost all complications.

A strong effect was seen for cardiac complications in patients with knee replacement and for wound complications in people who had hip replacement. Similar patterns were observed for resource utilization, particularly in length of hospital stay among patients with hip replacement.

Patients who receive a peripheral nerve block during hip or knee replacement surgery are less likely to experience complications, according to a recent large retrospective study.

Researchers reviewed more than 1 million hip and knee replacements performed between 2006 and 2013 using data from approximately 3,000 hospitals in the United States.

Investigators compiled information on cardiac, pulmonary, gastrointestinal, and renal complications. They also determined the rate of infections, wound complications, and inpatient falls. In addition, they analyzed data on resource utilization, which included the number of blood transfusions needed, admission to an intensive care unit, opioid consumption, length of hospital stay, and the cost of hospitalization.

They looked at data for 342,726 patients who had hip replacement surgery and 719,426 who had knee replacement surgery.

Overall, 18% of the patients received a peripheral nerve block. They found the rate peripheral nerve block use among patients with knee replacement increased from 15.2% in 2006 to 24.5% in 2013. The use of peripheral nerve blocks was associated with significantly lower odds for almost all complications.

A strong effect was seen for cardiac complications in patients with knee replacement and for wound complications in people who had hip replacement. Similar patterns were observed for resource utilization, particularly in length of hospital stay among patients with hip replacement.

VANCOUVER—Language proficiency affects a person’s results on the King-Devick concussion screening test, according to research presented at the 68th Annual Meeting of the American Academy of Neurology. In a study at New York University (NYU), it took 27 healthy, native English-speaking volunteers 42.8 seconds to complete the test, which is about average for nonconcussed subjects.

However, it took 27 other volunteers for whom English was a second language 54.4 seconds to complete the test. Had the test been given on the sidelines instead of in a laboratory, the extra 12 seconds might easily have been mistaken as a sign of serious concussion because concussions generally add about 5 seconds to the King-Devick score.

“A prolongation of 12 seconds in non-native English speakers has real clinical implications,” said lead investigator Katharine Dempsey, a medical student and member of the eye movement research team in the department of neurology at NYU.

Katharine Dempsey

The King-Devick test is an increasingly popular sideline screening tool used widely in professional sports. Subjects are timed as they read out loud and in English three sets of 40 numbers. Each set is progressively more difficult to read. The test is administered by flash cards or, as in the study, by computer.

In all, 18 languages were spoken by the group of non-native English speakers. The most common native languages in this group were Spanish and Chinese. All of the non-native speakers at NYU were proficient in English, but their native languages were often dominant, meaning that they were used at home and to perform mental arithmetic. Some subjects did not use Arabic numerals or read from right to left in their native tongues.

Instructions for the King-Devick tool recommend comparing subjects’ performance with their own preseason baseline scores; the NYU findings emphasize the importance of this technique when subjects aren’t native English speakers. The investigators point out that when baseline scores are unavailable, non-native English speakers may be scored against reference ranges for native speakers.“There’s incredible utility in using a sideline concussion screening test, but we definitely have to get out the message that the best practice is to take an athlete’s own preseason baseline. We have to be incredibly cautious when comparing test times of non-native English speakers to a normative database for native speakers,” Ms. Dempsey said.

The participants were in their early 30s, on average, and had no histories of concussion. The majority were women, and most were NYU employees or their friends.

The researchers also tracked eye movements during testing. Non-native speakers had more saccades (149 vs 135), but also fixated longer on numbers before initiating eye movement (345.4 milliseconds vs 288.0 milliseconds). Lag time correlated with native language dominance and suggests longer processing time.

The next step for research is to test how well patients perform on the King-Devick test in their native languages, Ms. Dempsey said.

—M. Alexander Otto

VANCOUVER—Language proficiency affects a person’s results on the King-Devick concussion screening test, according to research presented at the 68th Annual Meeting of the American Academy of Neurology. In a study at New York University (NYU), it took 27 healthy, native English-speaking volunteers 42.8 seconds to complete the test, which is about average for nonconcussed subjects.

However, it took 27 other volunteers for whom English was a second language 54.4 seconds to complete the test. Had the test been given on the sidelines instead of in a laboratory, the extra 12 seconds might easily have been mistaken as a sign of serious concussion because concussions generally add about 5 seconds to the King-Devick score.

“A prolongation of 12 seconds in non-native English speakers has real clinical implications,” said lead investigator Katharine Dempsey, a medical student and member of the eye movement research team in the department of neurology at NYU.

Katharine Dempsey

The King-Devick test is an increasingly popular sideline screening tool used widely in professional sports. Subjects are timed as they read out loud and in English three sets of 40 numbers. Each set is progressively more difficult to read. The test is administered by flash cards or, as in the study, by computer.

In all, 18 languages were spoken by the group of non-native English speakers. The most common native languages in this group were Spanish and Chinese. All of the non-native speakers at NYU were proficient in English, but their native languages were often dominant, meaning that they were used at home and to perform mental arithmetic. Some subjects did not use Arabic numerals or read from right to left in their native tongues.

Instructions for the King-Devick tool recommend comparing subjects’ performance with their own preseason baseline scores; the NYU findings emphasize the importance of this technique when subjects aren’t native English speakers. The investigators point out that when baseline scores are unavailable, non-native English speakers may be scored against reference ranges for native speakers.“There’s incredible utility in using a sideline concussion screening test, but we definitely have to get out the message that the best practice is to take an athlete’s own preseason baseline. We have to be incredibly cautious when comparing test times of non-native English speakers to a normative database for native speakers,” Ms. Dempsey said.

The participants were in their early 30s, on average, and had no histories of concussion. The majority were women, and most were NYU employees or their friends.

The researchers also tracked eye movements during testing. Non-native speakers had more saccades (149 vs 135), but also fixated longer on numbers before initiating eye movement (345.4 milliseconds vs 288.0 milliseconds). Lag time correlated with native language dominance and suggests longer processing time.

The next step for research is to test how well patients perform on the King-Devick test in their native languages, Ms. Dempsey said.

—M. Alexander Otto

VANCOUVER—Language proficiency affects a person’s results on the King-Devick concussion screening test, according to research presented at the 68th Annual Meeting of the American Academy of Neurology. In a study at New York University (NYU), it took 27 healthy, native English-speaking volunteers 42.8 seconds to complete the test, which is about average for nonconcussed subjects.

However, it took 27 other volunteers for whom English was a second language 54.4 seconds to complete the test. Had the test been given on the sidelines instead of in a laboratory, the extra 12 seconds might easily have been mistaken as a sign of serious concussion because concussions generally add about 5 seconds to the King-Devick score.

“A prolongation of 12 seconds in non-native English speakers has real clinical implications,” said lead investigator Katharine Dempsey, a medical student and member of the eye movement research team in the department of neurology at NYU.

Katharine Dempsey

The King-Devick test is an increasingly popular sideline screening tool used widely in professional sports. Subjects are timed as they read out loud and in English three sets of 40 numbers. Each set is progressively more difficult to read. The test is administered by flash cards or, as in the study, by computer.

In all, 18 languages were spoken by the group of non-native English speakers. The most common native languages in this group were Spanish and Chinese. All of the non-native speakers at NYU were proficient in English, but their native languages were often dominant, meaning that they were used at home and to perform mental arithmetic. Some subjects did not use Arabic numerals or read from right to left in their native tongues.

Instructions for the King-Devick tool recommend comparing subjects’ performance with their own preseason baseline scores; the NYU findings emphasize the importance of this technique when subjects aren’t native English speakers. The investigators point out that when baseline scores are unavailable, non-native English speakers may be scored against reference ranges for native speakers.“There’s incredible utility in using a sideline concussion screening test, but we definitely have to get out the message that the best practice is to take an athlete’s own preseason baseline. We have to be incredibly cautious when comparing test times of non-native English speakers to a normative database for native speakers,” Ms. Dempsey said.

The participants were in their early 30s, on average, and had no histories of concussion. The majority were women, and most were NYU employees or their friends.

The researchers also tracked eye movements during testing. Non-native speakers had more saccades (149 vs 135), but also fixated longer on numbers before initiating eye movement (345.4 milliseconds vs 288.0 milliseconds). Lag time correlated with native language dominance and suggests longer processing time.

The next step for research is to test how well patients perform on the King-Devick test in their native languages, Ms. Dempsey said.

—M. Alexander Otto

Aspects of spatial navigation may be particularly sensitive for detecting the earliest cognitive deficits of Alzheimer’s disease, according to a study published April 26 in the Journal of Alzheimer’s Disease. This study included 42 clinically normal people without preclinical Alzheimer’s disease, 13 clinically normal people with preclinical Alzheimer’s disease, and 16 people with early-stage symptomatic Alzheimer’s disease. Preclinical Alzheimer’s disease was defined based on CSF Aβ42 levels below 500 pg/mL. Preclinical Alzheimer’s disease was associated with deficits in the use of a wayfinding strategy, but not in the use of a route-learning strategy. In addition, post hoc analyses indicated that wayfinding performance had moderate sensitivity and specificity. Results also confirmed early-stage symptomatic Alzheimer’s disease-related deficits in the use of wayfinding and route-learning strategies.

One meal per week of seafood and long-chain omega-3 fatty acids protects against decline in multiple cognitive domains, according to a study published online ahead of print May 4 in Neurology. Researchers examined 915 participants who completed at least one follow-up cognitive assessment and provided dietary data. Scores for global cognitive function and five cognitive domains were assessed using 19 cognitive tests. Consumption of seafood was associated with slower decline in semantic memory and perceptual speed in separate models adjusted for age, sex, education, participation in cognitive activities, physical activity, alcohol consumption, smoking, and total energy intake. In secondary analyses, APOE ε4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain omega-3 intake from food.

Persistent environmental pollutants measured in blood are significantly associated with amyotrophic lateral sclerosis (ALS) and may represent modifiable risk factors, according to a study published online ahead of print May 9 in JAMA Neurology. Participants included 156 cases and 128 controls. Complete demographic and pollutant data were available for 101 cases and 110 controls. Survey data revealed that reported pesticide exposure in the cumulative exposure windows was significantly associated with ALS. A multivariable model of measured persistent environmental pollutants in the blood, representing cumulative occupational and residential exposure, showed increased odds of ALS for two organochlorine pesticides, two polychlorinated biphenyls, and one brominated flame retardant. There was modest concordance between survey data and the measurements of persistent environmental pollutants in blood. Additionally, tau correlation coefficients ranged from –0.18 to 0.24.

Outcomes of sports-related concussion vary according to the level of competition, according to a study published online ahead of print May 2 in JAMA Pediatrics. Three injury surveillance programs recorded 1,429 sports-related concussions between 2012 and 2014 among youth, high school, and college-level football athletes. Across all levels, 15.3% of concussions resulted in return to play at least 30 days after the concussion, and 3.1% resulted in return to play less than 24 hours after the concussion. Compared with youth, a higher number of concussion symptoms were reported in high school athletes. Compared with college athletes, the odds of return to play at least 30 days after injury were larger in youth athletes and high school athletes.

A screening test for newborns identifies infants with Niemann-Pick type C, according to a study published May 4 in Science Translational Medicine. The bile acids most elevated in infants with Niemann-Pick type C were identified as 3β,5α,6β-trihydroxycholanic acid and its glycine conjugate, which were shown to be metabolites of cholestane-3β,5α,6β-triol. Analysis of dried blood spots from 4,992 controls, 134 Niemann-Pick type C carriers, and 44 subjects with Niemann-Pick type C provided 100% sensitivity and specificity in the study samples. The researchers found that infants with Niemann-Pick type C have about thirtyfold higher amounts of 3β,5α,6β-trihydroxycholanic acid in the blood than healthy individuals. In addition, levels of 3β,5α,6β-trihydroxycholanic acid also could distinguish between patients with Niemann-Pick type C and carriers of the disease who show no symptoms.

The FDA has approved pimavanserin for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. The approval is based on data from a phase III study and other supportive studies. In the phase III study, pimavanserin significantly reduced the frequency and severity of psychotic symptoms, compared with placebo, on the Scale for Assessment of Positive Symptoms—Parkinson’s Disease. This benefit was achieved without impairing motor function. The most common adverse reactions in this study were peripheral edema and confusional state. The drug has a boxed warning alerting health care professionals about an increased risk of death associated with the use of atypical antipsychotics to treat older people with dementia-related psychosis. Acadia Pharmaceuticals, headquartered in San Diego, markets the product under the name Nuplazid.

Compared with the standard dose of t-PA (0.9 mg/kg), a low dose (0.6 mg/kg) is associated with slightly reduced rates of bleeding and mortality, according to a study published online ahead of print May 10 in the New England Journal of Medicine. Using a two-by-two quasi-factorial open-label design, researchers randomly assigned 3,310 patients who were eligible for thrombolytic therapy to low-dose IV t-PA or the standard dose. At 90 days, 53.2% of participants in the low-dose group had died or had disability, compared with 51.1% of participants in the standard-dose group. Major symptomatic intracerebral hemorrhage occurred in 1.0% of the participants in the low-dose group and in 2.1% of the participants in the standard-dose group. Fatal events occurred within seven days in 0.5% and 1.5% of participants, respectively.

Triptans and dihydroergotamine (DHE) are not associated with acute or subacute ischemic vascular events in the abortive treatment of basilar migraine or hemiplegic migraine, according to a study published online ahead of print April 8 in Headache. A retrospective chart review of 80 patients with basilar migraine or hemiplegic migraine who received acute abortive treatment with either triptans or DHE was conducted at four headache centers to assess the frequency of ischemic vascular events after administration. No stroke or myocardial infarction was reported. In the triptan group, five patients reported adverse effects that included gastrointestinal upset, rash, neck dystonia, nightmares, and flushing. In the DHE group, five patients had adverse events that included chest tightness, dystonic reaction, transient asymptomatic anterior T wave inversion, and agitation.

The FDA has approved Fycompa (perampanel) CIII oral suspension as adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures, and of primary generalized tonic-clonic seizures in patients with epilepsy age 12 and older. The oral suspension formulation is a bioequivalent, interchangeable alternative to the Fycompa tablet formulation. The approval of Fycompa CIII oral suspension was based on a study that demonstrated bioequivalence between a single dose of perampanel oral suspension and a single dose of perampanel tablet when administered under fasted conditions in healthy subjects. Fycompa is an oral medication and the only FDA-approved noncompetitive AMPA receptor antagonist. Its most common side effects include dizziness, sleepiness, headache, tiredness, and irritability. Eisai, headquartered in Woodcliff Lake, New Jersey, markets the drug.

In patients with acute ischemic stroke or transient ischemic attack, ticagrelor is not superior to aspirin in reducing the rate of stroke, myocardial infarction, or death at 90 days, according to a study published online ahead of print May 10 in the New England Journal of Medicine. Included in this study were 13,199 patients with nonsevere ischemic stroke or high-risk transient ischemic attack who had not received IV or intra-arterial thrombolysis and who had not had a cardioembolic stroke. During 90 days of treatment, a primary end point event (ie, stroke, myocardial infarction, or death) occurred in 442 of the 6,589 patients treated with ticagrelor, versus 497 of the 6,610 patients treated with aspirin. Ischemic stroke occurred in 385 patients treated with ticagrelor and in 441 patients treated with aspirin.

Physicians differ substantially when giving prognoses and treatment recommendations for patients with intracerebral hemorrhage, according to a study published online ahead of print April 15 in Neurology. A written survey with two intracerebral hemorrhage scenarios was completed by 742 practicing neurologists and neurosurgeons. Physician predictions of 30-day mortality varied widely, as did treatment recommendations. Responses encompassed the full range of options for each case. No physician demographic or personality characteristics were associated with treatment recommendations. Providing a prognostic score changed treatment recommendations, and the effect differed across cases. When the prognostic score suggested a 0% chance of functional independence, the likelihood of treatment limitations was increased, compared with no prognostic score. Conversely, if the score suggested a 66% chance of independence, treatment limitations were less likely.

Mitoxantrone slightly increases the overall incidence of malignancies and significantly increases the risk of leukemia and colorectal cancer, according to a study published online ahead of print May 11 in Neurology. Researchers retrospectively examined all mitoxantrone-treated patients with multiple sclerosis seen between 1994 and 2007 at one hospital. They collected follow-up information on medically confirmed malignancies, life status, and cause of death, as of 2010. The incidence ratio of malignancy was 1.50. The standardized incidence ratio of colorectal cancer was 2.98, and that of acute myeloid leukemia, 10.44. Higher age at treatment initiation was a risk factor, but neither cumulative mitoxantrone dose, treatment with other immunosuppressive drugs, nor sex was. In all, 55 patients died. Twelve deaths resulted from a malignancy, and 43 from other causes.

Tau tangles provide a good indication of cognitive decline in the later stages of Alzheimer’s disease, according to a study published May 11 in Science Translational Medicine. The study suggests that while β-amyloid remains a critical marker for the early detection of Alzheimer’s disease, tau may be more useful for tracking disease progression and, potentially, patient response to therapies. Researchers analyzed PET imaging of tau and β-amyloid in 10 patients with mild Alzheimer’s disease and 36 healthy adults. Compared with amyloid plaques, tau tangles in the temporal lobe more closely correlated with cognitive deficits, as measured by a battery of memory tests. Tau deposits in the temporal lobe also were strongly associated with tau detected in the patients’ CSF. Tau therefore may better predict dementia during Alzheimer’s disease progression than β-amyloid.

—Kimberly Williams

Aspects of spatial navigation may be particularly sensitive for detecting the earliest cognitive deficits of Alzheimer’s disease, according to a study published April 26 in the Journal of Alzheimer’s Disease. This study included 42 clinically normal people without preclinical Alzheimer’s disease, 13 clinically normal people with preclinical Alzheimer’s disease, and 16 people with early-stage symptomatic Alzheimer’s disease. Preclinical Alzheimer’s disease was defined based on CSF Aβ42 levels below 500 pg/mL. Preclinical Alzheimer’s disease was associated with deficits in the use of a wayfinding strategy, but not in the use of a route-learning strategy. In addition, post hoc analyses indicated that wayfinding performance had moderate sensitivity and specificity. Results also confirmed early-stage symptomatic Alzheimer’s disease-related deficits in the use of wayfinding and route-learning strategies.

One meal per week of seafood and long-chain omega-3 fatty acids protects against decline in multiple cognitive domains, according to a study published online ahead of print May 4 in Neurology. Researchers examined 915 participants who completed at least one follow-up cognitive assessment and provided dietary data. Scores for global cognitive function and five cognitive domains were assessed using 19 cognitive tests. Consumption of seafood was associated with slower decline in semantic memory and perceptual speed in separate models adjusted for age, sex, education, participation in cognitive activities, physical activity, alcohol consumption, smoking, and total energy intake. In secondary analyses, APOE ε4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain omega-3 intake from food.

Persistent environmental pollutants measured in blood are significantly associated with amyotrophic lateral sclerosis (ALS) and may represent modifiable risk factors, according to a study published online ahead of print May 9 in JAMA Neurology. Participants included 156 cases and 128 controls. Complete demographic and pollutant data were available for 101 cases and 110 controls. Survey data revealed that reported pesticide exposure in the cumulative exposure windows was significantly associated with ALS. A multivariable model of measured persistent environmental pollutants in the blood, representing cumulative occupational and residential exposure, showed increased odds of ALS for two organochlorine pesticides, two polychlorinated biphenyls, and one brominated flame retardant. There was modest concordance between survey data and the measurements of persistent environmental pollutants in blood. Additionally, tau correlation coefficients ranged from –0.18 to 0.24.

Outcomes of sports-related concussion vary according to the level of competition, according to a study published online ahead of print May 2 in JAMA Pediatrics. Three injury surveillance programs recorded 1,429 sports-related concussions between 2012 and 2014 among youth, high school, and college-level football athletes. Across all levels, 15.3% of concussions resulted in return to play at least 30 days after the concussion, and 3.1% resulted in return to play less than 24 hours after the concussion. Compared with youth, a higher number of concussion symptoms were reported in high school athletes. Compared with college athletes, the odds of return to play at least 30 days after injury were larger in youth athletes and high school athletes.

A screening test for newborns identifies infants with Niemann-Pick type C, according to a study published May 4 in Science Translational Medicine. The bile acids most elevated in infants with Niemann-Pick type C were identified as 3β,5α,6β-trihydroxycholanic acid and its glycine conjugate, which were shown to be metabolites of cholestane-3β,5α,6β-triol. Analysis of dried blood spots from 4,992 controls, 134 Niemann-Pick type C carriers, and 44 subjects with Niemann-Pick type C provided 100% sensitivity and specificity in the study samples. The researchers found that infants with Niemann-Pick type C have about thirtyfold higher amounts of 3β,5α,6β-trihydroxycholanic acid in the blood than healthy individuals. In addition, levels of 3β,5α,6β-trihydroxycholanic acid also could distinguish between patients with Niemann-Pick type C and carriers of the disease who show no symptoms.

The FDA has approved pimavanserin for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. The approval is based on data from a phase III study and other supportive studies. In the phase III study, pimavanserin significantly reduced the frequency and severity of psychotic symptoms, compared with placebo, on the Scale for Assessment of Positive Symptoms—Parkinson’s Disease. This benefit was achieved without impairing motor function. The most common adverse reactions in this study were peripheral edema and confusional state. The drug has a boxed warning alerting health care professionals about an increased risk of death associated with the use of atypical antipsychotics to treat older people with dementia-related psychosis. Acadia Pharmaceuticals, headquartered in San Diego, markets the product under the name Nuplazid.

Compared with the standard dose of t-PA (0.9 mg/kg), a low dose (0.6 mg/kg) is associated with slightly reduced rates of bleeding and mortality, according to a study published online ahead of print May 10 in the New England Journal of Medicine. Using a two-by-two quasi-factorial open-label design, researchers randomly assigned 3,310 patients who were eligible for thrombolytic therapy to low-dose IV t-PA or the standard dose. At 90 days, 53.2% of participants in the low-dose group had died or had disability, compared with 51.1% of participants in the standard-dose group. Major symptomatic intracerebral hemorrhage occurred in 1.0% of the participants in the low-dose group and in 2.1% of the participants in the standard-dose group. Fatal events occurred within seven days in 0.5% and 1.5% of participants, respectively.

Triptans and dihydroergotamine (DHE) are not associated with acute or subacute ischemic vascular events in the abortive treatment of basilar migraine or hemiplegic migraine, according to a study published online ahead of print April 8 in Headache. A retrospective chart review of 80 patients with basilar migraine or hemiplegic migraine who received acute abortive treatment with either triptans or DHE was conducted at four headache centers to assess the frequency of ischemic vascular events after administration. No stroke or myocardial infarction was reported. In the triptan group, five patients reported adverse effects that included gastrointestinal upset, rash, neck dystonia, nightmares, and flushing. In the DHE group, five patients had adverse events that included chest tightness, dystonic reaction, transient asymptomatic anterior T wave inversion, and agitation.

The FDA has approved Fycompa (perampanel) CIII oral suspension as adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures, and of primary generalized tonic-clonic seizures in patients with epilepsy age 12 and older. The oral suspension formulation is a bioequivalent, interchangeable alternative to the Fycompa tablet formulation. The approval of Fycompa CIII oral suspension was based on a study that demonstrated bioequivalence between a single dose of perampanel oral suspension and a single dose of perampanel tablet when administered under fasted conditions in healthy subjects. Fycompa is an oral medication and the only FDA-approved noncompetitive AMPA receptor antagonist. Its most common side effects include dizziness, sleepiness, headache, tiredness, and irritability. Eisai, headquartered in Woodcliff Lake, New Jersey, markets the drug.

In patients with acute ischemic stroke or transient ischemic attack, ticagrelor is not superior to aspirin in reducing the rate of stroke, myocardial infarction, or death at 90 days, according to a study published online ahead of print May 10 in the New England Journal of Medicine. Included in this study were 13,199 patients with nonsevere ischemic stroke or high-risk transient ischemic attack who had not received IV or intra-arterial thrombolysis and who had not had a cardioembolic stroke. During 90 days of treatment, a primary end point event (ie, stroke, myocardial infarction, or death) occurred in 442 of the 6,589 patients treated with ticagrelor, versus 497 of the 6,610 patients treated with aspirin. Ischemic stroke occurred in 385 patients treated with ticagrelor and in 441 patients treated with aspirin.

Physicians differ substantially when giving prognoses and treatment recommendations for patients with intracerebral hemorrhage, according to a study published online ahead of print April 15 in Neurology. A written survey with two intracerebral hemorrhage scenarios was completed by 742 practicing neurologists and neurosurgeons. Physician predictions of 30-day mortality varied widely, as did treatment recommendations. Responses encompassed the full range of options for each case. No physician demographic or personality characteristics were associated with treatment recommendations. Providing a prognostic score changed treatment recommendations, and the effect differed across cases. When the prognostic score suggested a 0% chance of functional independence, the likelihood of treatment limitations was increased, compared with no prognostic score. Conversely, if the score suggested a 66% chance of independence, treatment limitations were less likely.

Mitoxantrone slightly increases the overall incidence of malignancies and significantly increases the risk of leukemia and colorectal cancer, according to a study published online ahead of print May 11 in Neurology. Researchers retrospectively examined all mitoxantrone-treated patients with multiple sclerosis seen between 1994 and 2007 at one hospital. They collected follow-up information on medically confirmed malignancies, life status, and cause of death, as of 2010. The incidence ratio of malignancy was 1.50. The standardized incidence ratio of colorectal cancer was 2.98, and that of acute myeloid leukemia, 10.44. Higher age at treatment initiation was a risk factor, but neither cumulative mitoxantrone dose, treatment with other immunosuppressive drugs, nor sex was. In all, 55 patients died. Twelve deaths resulted from a malignancy, and 43 from other causes.

Tau tangles provide a good indication of cognitive decline in the later stages of Alzheimer’s disease, according to a study published May 11 in Science Translational Medicine. The study suggests that while β-amyloid remains a critical marker for the early detection of Alzheimer’s disease, tau may be more useful for tracking disease progression and, potentially, patient response to therapies. Researchers analyzed PET imaging of tau and β-amyloid in 10 patients with mild Alzheimer’s disease and 36 healthy adults. Compared with amyloid plaques, tau tangles in the temporal lobe more closely correlated with cognitive deficits, as measured by a battery of memory tests. Tau deposits in the temporal lobe also were strongly associated with tau detected in the patients’ CSF. Tau therefore may better predict dementia during Alzheimer’s disease progression than β-amyloid.

—Kimberly Williams

Aspects of spatial navigation may be particularly sensitive for detecting the earliest cognitive deficits of Alzheimer’s disease, according to a study published April 26 in the Journal of Alzheimer’s Disease. This study included 42 clinically normal people without preclinical Alzheimer’s disease, 13 clinically normal people with preclinical Alzheimer’s disease, and 16 people with early-stage symptomatic Alzheimer’s disease. Preclinical Alzheimer’s disease was defined based on CSF Aβ42 levels below 500 pg/mL. Preclinical Alzheimer’s disease was associated with deficits in the use of a wayfinding strategy, but not in the use of a route-learning strategy. In addition, post hoc analyses indicated that wayfinding performance had moderate sensitivity and specificity. Results also confirmed early-stage symptomatic Alzheimer’s disease-related deficits in the use of wayfinding and route-learning strategies.

One meal per week of seafood and long-chain omega-3 fatty acids protects against decline in multiple cognitive domains, according to a study published online ahead of print May 4 in Neurology. Researchers examined 915 participants who completed at least one follow-up cognitive assessment and provided dietary data. Scores for global cognitive function and five cognitive domains were assessed using 19 cognitive tests. Consumption of seafood was associated with slower decline in semantic memory and perceptual speed in separate models adjusted for age, sex, education, participation in cognitive activities, physical activity, alcohol consumption, smoking, and total energy intake. In secondary analyses, APOE ε4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain omega-3 intake from food.

Persistent environmental pollutants measured in blood are significantly associated with amyotrophic lateral sclerosis (ALS) and may represent modifiable risk factors, according to a study published online ahead of print May 9 in JAMA Neurology. Participants included 156 cases and 128 controls. Complete demographic and pollutant data were available for 101 cases and 110 controls. Survey data revealed that reported pesticide exposure in the cumulative exposure windows was significantly associated with ALS. A multivariable model of measured persistent environmental pollutants in the blood, representing cumulative occupational and residential exposure, showed increased odds of ALS for two organochlorine pesticides, two polychlorinated biphenyls, and one brominated flame retardant. There was modest concordance between survey data and the measurements of persistent environmental pollutants in blood. Additionally, tau correlation coefficients ranged from –0.18 to 0.24.

Outcomes of sports-related concussion vary according to the level of competition, according to a study published online ahead of print May 2 in JAMA Pediatrics. Three injury surveillance programs recorded 1,429 sports-related concussions between 2012 and 2014 among youth, high school, and college-level football athletes. Across all levels, 15.3% of concussions resulted in return to play at least 30 days after the concussion, and 3.1% resulted in return to play less than 24 hours after the concussion. Compared with youth, a higher number of concussion symptoms were reported in high school athletes. Compared with college athletes, the odds of return to play at least 30 days after injury were larger in youth athletes and high school athletes.

A screening test for newborns identifies infants with Niemann-Pick type C, according to a study published May 4 in Science Translational Medicine. The bile acids most elevated in infants with Niemann-Pick type C were identified as 3β,5α,6β-trihydroxycholanic acid and its glycine conjugate, which were shown to be metabolites of cholestane-3β,5α,6β-triol. Analysis of dried blood spots from 4,992 controls, 134 Niemann-Pick type C carriers, and 44 subjects with Niemann-Pick type C provided 100% sensitivity and specificity in the study samples. The researchers found that infants with Niemann-Pick type C have about thirtyfold higher amounts of 3β,5α,6β-trihydroxycholanic acid in the blood than healthy individuals. In addition, levels of 3β,5α,6β-trihydroxycholanic acid also could distinguish between patients with Niemann-Pick type C and carriers of the disease who show no symptoms.

The FDA has approved pimavanserin for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. The approval is based on data from a phase III study and other supportive studies. In the phase III study, pimavanserin significantly reduced the frequency and severity of psychotic symptoms, compared with placebo, on the Scale for Assessment of Positive Symptoms—Parkinson’s Disease. This benefit was achieved without impairing motor function. The most common adverse reactions in this study were peripheral edema and confusional state. The drug has a boxed warning alerting health care professionals about an increased risk of death associated with the use of atypical antipsychotics to treat older people with dementia-related psychosis. Acadia Pharmaceuticals, headquartered in San Diego, markets the product under the name Nuplazid.

Compared with the standard dose of t-PA (0.9 mg/kg), a low dose (0.6 mg/kg) is associated with slightly reduced rates of bleeding and mortality, according to a study published online ahead of print May 10 in the New England Journal of Medicine. Using a two-by-two quasi-factorial open-label design, researchers randomly assigned 3,310 patients who were eligible for thrombolytic therapy to low-dose IV t-PA or the standard dose. At 90 days, 53.2% of participants in the low-dose group had died or had disability, compared with 51.1% of participants in the standard-dose group. Major symptomatic intracerebral hemorrhage occurred in 1.0% of the participants in the low-dose group and in 2.1% of the participants in the standard-dose group. Fatal events occurred within seven days in 0.5% and 1.5% of participants, respectively.

Triptans and dihydroergotamine (DHE) are not associated with acute or subacute ischemic vascular events in the abortive treatment of basilar migraine or hemiplegic migraine, according to a study published online ahead of print April 8 in Headache. A retrospective chart review of 80 patients with basilar migraine or hemiplegic migraine who received acute abortive treatment with either triptans or DHE was conducted at four headache centers to assess the frequency of ischemic vascular events after administration. No stroke or myocardial infarction was reported. In the triptan group, five patients reported adverse effects that included gastrointestinal upset, rash, neck dystonia, nightmares, and flushing. In the DHE group, five patients had adverse events that included chest tightness, dystonic reaction, transient asymptomatic anterior T wave inversion, and agitation.

The FDA has approved Fycompa (perampanel) CIII oral suspension as adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures, and of primary generalized tonic-clonic seizures in patients with epilepsy age 12 and older. The oral suspension formulation is a bioequivalent, interchangeable alternative to the Fycompa tablet formulation. The approval of Fycompa CIII oral suspension was based on a study that demonstrated bioequivalence between a single dose of perampanel oral suspension and a single dose of perampanel tablet when administered under fasted conditions in healthy subjects. Fycompa is an oral medication and the only FDA-approved noncompetitive AMPA receptor antagonist. Its most common side effects include dizziness, sleepiness, headache, tiredness, and irritability. Eisai, headquartered in Woodcliff Lake, New Jersey, markets the drug.

In patients with acute ischemic stroke or transient ischemic attack, ticagrelor is not superior to aspirin in reducing the rate of stroke, myocardial infarction, or death at 90 days, according to a study published online ahead of print May 10 in the New England Journal of Medicine. Included in this study were 13,199 patients with nonsevere ischemic stroke or high-risk transient ischemic attack who had not received IV or intra-arterial thrombolysis and who had not had a cardioembolic stroke. During 90 days of treatment, a primary end point event (ie, stroke, myocardial infarction, or death) occurred in 442 of the 6,589 patients treated with ticagrelor, versus 497 of the 6,610 patients treated with aspirin. Ischemic stroke occurred in 385 patients treated with ticagrelor and in 441 patients treated with aspirin.

Physicians differ substantially when giving prognoses and treatment recommendations for patients with intracerebral hemorrhage, according to a study published online ahead of print April 15 in Neurology. A written survey with two intracerebral hemorrhage scenarios was completed by 742 practicing neurologists and neurosurgeons. Physician predictions of 30-day mortality varied widely, as did treatment recommendations. Responses encompassed the full range of options for each case. No physician demographic or personality characteristics were associated with treatment recommendations. Providing a prognostic score changed treatment recommendations, and the effect differed across cases. When the prognostic score suggested a 0% chance of functional independence, the likelihood of treatment limitations was increased, compared with no prognostic score. Conversely, if the score suggested a 66% chance of independence, treatment limitations were less likely.

Mitoxantrone slightly increases the overall incidence of malignancies and significantly increases the risk of leukemia and colorectal cancer, according to a study published online ahead of print May 11 in Neurology. Researchers retrospectively examined all mitoxantrone-treated patients with multiple sclerosis seen between 1994 and 2007 at one hospital. They collected follow-up information on medically confirmed malignancies, life status, and cause of death, as of 2010. The incidence ratio of malignancy was 1.50. The standardized incidence ratio of colorectal cancer was 2.98, and that of acute myeloid leukemia, 10.44. Higher age at treatment initiation was a risk factor, but neither cumulative mitoxantrone dose, treatment with other immunosuppressive drugs, nor sex was. In all, 55 patients died. Twelve deaths resulted from a malignancy, and 43 from other causes.

Tau tangles provide a good indication of cognitive decline in the later stages of Alzheimer’s disease, according to a study published May 11 in Science Translational Medicine. The study suggests that while β-amyloid remains a critical marker for the early detection of Alzheimer’s disease, tau may be more useful for tracking disease progression and, potentially, patient response to therapies. Researchers analyzed PET imaging of tau and β-amyloid in 10 patients with mild Alzheimer’s disease and 36 healthy adults. Compared with amyloid plaques, tau tangles in the temporal lobe more closely correlated with cognitive deficits, as measured by a battery of memory tests. Tau deposits in the temporal lobe also were strongly associated with tau detected in the patients’ CSF. Tau therefore may better predict dementia during Alzheimer’s disease progression than β-amyloid.

—Kimberly Williams

A 59-year-old woman presents urgently to dermatology for evaluation of very itchy lesions that manifested at least 20 years ago. They have been previously diagnosed as staph infection, fungal infection, psoriasis, and scabies but have not responded to a variety of topical steroid creams and topical antibacterials (eg, triple-antibiotic cream, mupirocin, and clindamycin solution). The patient has also been prescribed numerous oral antibiotics, the most recent of which was a 10-day course of clindamycin. This induced a raging case of diarrhea; her primary care provider subsequently referred her to dermatology.

She denies any family history of skin problems until her sister, who has accompanied her to this appointment, mentions that she and her mother have had similar problems for decades. More questioning reveals that all three women also have extensive psychiatric histories of chronic anxiety and depression.

When pressed, the patient and her sister admit to picking at their skin “constantly,” but especially when under stress.

EXAMINATION
Most of the patient’s lesions—round to oval, orangish red, scaly plaques that range from 2 to 5 cm—are on her legs, below her knees. There are about 15 lesions total. They look and feel very thick but have no increased warmth or tenderness. The erythema is confined to the lesions and does not extend into the surrounding areas.

Punch biopsy of one leg lesion shows a hypertrophic epidermis with focal parakeratosis, elongation of rete ridges, and perhaps most importantly, no signs of other items in the differential (such as psoriasis or skin cancer).

Elsewhere on her skin, extensive punctate disciform scarring extends across her upper back, stopping abruptly at the T2 level. The skin below remains totally clear.

What is the diagnosis?

DISCUSSION
The correct diagnosis is prurigo nodularis (PN), which was first described in 1909 and has been extensively studied since. Though much remains unknown about PN, we know that, typically, the patient plays a major role in the genesis and perpetuation of the condition. In other words, these patients are pickers—but as they’ll tell you, they “wouldn’t pick if the lesions didn’t itch.” It does appear that they have a much lower threshold for itching than the general population.

Personal and family history of serious, ongoing bouts of depression and anxiety, as seen in this patient, are also typical among PN patients. Women appear to be far more likely to be diagnosed with PN, though there is no documentation of this in the literature.

These observations, while helpful for diagnosis, still don’t fully explain exactly why one person has PN while another doesn’t.

Besides the biopsy results, other keys to distinguishing PN include the characteristic lesions themselves, as well as the sparing of sites out of the patient’s reach. As is often the case, multiple old scars were seen on this patient’s upper back, confirming the chronicity of the condition.

In addition to educating patients about their role in the creation and perpetuation of PN, I find the most useful treatment to be intralesional triamcinolone in a 10-mg/cc strength (1/4 cc stock triamcinolone diluted in ¾ cc lidocaine), delivered directly into the lesion by 30-gauge needle Alternatively, a class 1 topical steroid cream (eg, clobetasol 0.05%) can be applied twice daily and then covered with a bandage. In cooler weather, when patients tend to bundle up, additional layers of clothing help to create a barrier that prevents patients from picking as much.

New cases of “picking” suggest the possibility of other diagnoses, including renal or hepatic failure, occult cancer, or other skin disease (eg, mastocytosis).

TAKE-HOME LEARNING POINTS
 • Prurigo nodularis (PN) often presents with multiple papules, nodules, and/or plaques that develop primarily as a result of picking, rubbing, or scratching the area.
 • PN patients appear to have a lowered threshold for itching, which may play a role in their disease.
• The differential for PN includes squamous cell carcinoma, psoriasis, atypical mycobacteria infection, and metastatic cancer.
• Biopsy plays a key role in establishing the correct diagnosis.
• Intralesional steroid injection with 10 mg/cc triamcinolone stops the itching and shrinks the lesion.

A 59-year-old woman presents urgently to dermatology for evaluation of very itchy lesions that manifested at least 20 years ago. They have been previously diagnosed as staph infection, fungal infection, psoriasis, and scabies but have not responded to a variety of topical steroid creams and topical antibacterials (eg, triple-antibiotic cream, mupirocin, and clindamycin solution). The patient has also been prescribed numerous oral antibiotics, the most recent of which was a 10-day course of clindamycin. This induced a raging case of diarrhea; her primary care provider subsequently referred her to dermatology.

She denies any family history of skin problems until her sister, who has accompanied her to this appointment, mentions that she and her mother have had similar problems for decades. More questioning reveals that all three women also have extensive psychiatric histories of chronic anxiety and depression.

When pressed, the patient and her sister admit to picking at their skin “constantly,” but especially when under stress.

EXAMINATION
Most of the patient’s lesions—round to oval, orangish red, scaly plaques that range from 2 to 5 cm—are on her legs, below her knees. There are about 15 lesions total. They look and feel very thick but have no increased warmth or tenderness. The erythema is confined to the lesions and does not extend into the surrounding areas.

Punch biopsy of one leg lesion shows a hypertrophic epidermis with focal parakeratosis, elongation of rete ridges, and perhaps most importantly, no signs of other items in the differential (such as psoriasis or skin cancer).

Elsewhere on her skin, extensive punctate disciform scarring extends across her upper back, stopping abruptly at the T2 level. The skin below remains totally clear.

What is the diagnosis?

DISCUSSION
The correct diagnosis is prurigo nodularis (PN), which was first described in 1909 and has been extensively studied since. Though much remains unknown about PN, we know that, typically, the patient plays a major role in the genesis and perpetuation of the condition. In other words, these patients are pickers—but as they’ll tell you, they “wouldn’t pick if the lesions didn’t itch.” It does appear that they have a much lower threshold for itching than the general population.

Personal and family history of serious, ongoing bouts of depression and anxiety, as seen in this patient, are also typical among PN patients. Women appear to be far more likely to be diagnosed with PN, though there is no documentation of this in the literature.

These observations, while helpful for diagnosis, still don’t fully explain exactly why one person has PN while another doesn’t.

Besides the biopsy results, other keys to distinguishing PN include the characteristic lesions themselves, as well as the sparing of sites out of the patient’s reach. As is often the case, multiple old scars were seen on this patient’s upper back, confirming the chronicity of the condition.

In addition to educating patients about their role in the creation and perpetuation of PN, I find the most useful treatment to be intralesional triamcinolone in a 10-mg/cc strength (1/4 cc stock triamcinolone diluted in ¾ cc lidocaine), delivered directly into the lesion by 30-gauge needle Alternatively, a class 1 topical steroid cream (eg, clobetasol 0.05%) can be applied twice daily and then covered with a bandage. In cooler weather, when patients tend to bundle up, additional layers of clothing help to create a barrier that prevents patients from picking as much.

New cases of “picking” suggest the possibility of other diagnoses, including renal or hepatic failure, occult cancer, or other skin disease (eg, mastocytosis).

TAKE-HOME LEARNING POINTS
 • Prurigo nodularis (PN) often presents with multiple papules, nodules, and/or plaques that develop primarily as a result of picking, rubbing, or scratching the area.
 • PN patients appear to have a lowered threshold for itching, which may play a role in their disease.
• The differential for PN includes squamous cell carcinoma, psoriasis, atypical mycobacteria infection, and metastatic cancer.
• Biopsy plays a key role in establishing the correct diagnosis.
• Intralesional steroid injection with 10 mg/cc triamcinolone stops the itching and shrinks the lesion.

A 59-year-old woman presents urgently to dermatology for evaluation of very itchy lesions that manifested at least 20 years ago. They have been previously diagnosed as staph infection, fungal infection, psoriasis, and scabies but have not responded to a variety of topical steroid creams and topical antibacterials (eg, triple-antibiotic cream, mupirocin, and clindamycin solution). The patient has also been prescribed numerous oral antibiotics, the most recent of which was a 10-day course of clindamycin. This induced a raging case of diarrhea; her primary care provider subsequently referred her to dermatology.

She denies any family history of skin problems until her sister, who has accompanied her to this appointment, mentions that she and her mother have had similar problems for decades. More questioning reveals that all three women also have extensive psychiatric histories of chronic anxiety and depression.

When pressed, the patient and her sister admit to picking at their skin “constantly,” but especially when under stress.

EXAMINATION
Most of the patient’s lesions—round to oval, orangish red, scaly plaques that range from 2 to 5 cm—are on her legs, below her knees. There are about 15 lesions total. They look and feel very thick but have no increased warmth or tenderness. The erythema is confined to the lesions and does not extend into the surrounding areas.

Punch biopsy of one leg lesion shows a hypertrophic epidermis with focal parakeratosis, elongation of rete ridges, and perhaps most importantly, no signs of other items in the differential (such as psoriasis or skin cancer).

Elsewhere on her skin, extensive punctate disciform scarring extends across her upper back, stopping abruptly at the T2 level. The skin below remains totally clear.

What is the diagnosis?

DISCUSSION
The correct diagnosis is prurigo nodularis (PN), which was first described in 1909 and has been extensively studied since. Though much remains unknown about PN, we know that, typically, the patient plays a major role in the genesis and perpetuation of the condition. In other words, these patients are pickers—but as they’ll tell you, they “wouldn’t pick if the lesions didn’t itch.” It does appear that they have a much lower threshold for itching than the general population.

Personal and family history of serious, ongoing bouts of depression and anxiety, as seen in this patient, are also typical among PN patients. Women appear to be far more likely to be diagnosed with PN, though there is no documentation of this in the literature.

These observations, while helpful for diagnosis, still don’t fully explain exactly why one person has PN while another doesn’t.

Besides the biopsy results, other keys to distinguishing PN include the characteristic lesions themselves, as well as the sparing of sites out of the patient’s reach. As is often the case, multiple old scars were seen on this patient’s upper back, confirming the chronicity of the condition.

In addition to educating patients about their role in the creation and perpetuation of PN, I find the most useful treatment to be intralesional triamcinolone in a 10-mg/cc strength (1/4 cc stock triamcinolone diluted in ¾ cc lidocaine), delivered directly into the lesion by 30-gauge needle Alternatively, a class 1 topical steroid cream (eg, clobetasol 0.05%) can be applied twice daily and then covered with a bandage. In cooler weather, when patients tend to bundle up, additional layers of clothing help to create a barrier that prevents patients from picking as much.

New cases of “picking” suggest the possibility of other diagnoses, including renal or hepatic failure, occult cancer, or other skin disease (eg, mastocytosis).

TAKE-HOME LEARNING POINTS
 • Prurigo nodularis (PN) often presents with multiple papules, nodules, and/or plaques that develop primarily as a result of picking, rubbing, or scratching the area.
 • PN patients appear to have a lowered threshold for itching, which may play a role in their disease.
• The differential for PN includes squamous cell carcinoma, psoriasis, atypical mycobacteria infection, and metastatic cancer.
• Biopsy plays a key role in establishing the correct diagnosis.
• Intralesional steroid injection with 10 mg/cc triamcinolone stops the itching and shrinks the lesion.

Venetoclax monotherapy was active, and even elicited minimal residual disease negativity in a proportion of patients with chronic lymphocytic leukemia (CLL) that was resistant or refractory to ibrutinib or idelalisib, Dr. Jeffrey Alan Jones of the Ohio State University Comprehensive Cancer Center, Columbus, and colleagues wrote in an abstract to be presented at the annual meeting of the American Society of Clinical Oncology.

The findings from their ongoing phase II study are the first prospective results to demonstrate efficacy in this poor-prognosis population, the researchers wrote. Earlier results from the study were reported at the American Society of Hematology meeting.

The 54 patients in the study, 25 of them refractory to ibrutinib and 6 to idelalisib, received venetoclax 20 mg daily followed by a 5-week ramp up in dosage to 400 mg daily. Over half of the patients had received more than five prior therapies; 83% did not have IGHV mutations, 20% had absolute lymphocyte counts exceeding 100 x 10⁹, 35% had 17p deletions, and 24% had at least one node that was 10 cm or larger.

Of the patients who had previously received ibrutinib, four discontinued venetoclax because of progressive disease and four others had respiratory failure, multiorgan failure, death of unknown cause, or consent withdrawal. Of those who previously received idelalisib, four halted therapy because of progressive disease and failure to respond. Of 48 evaluable patients, 38 previously received ibrutinib, and 10 previously received idelalisib.

The overall response rate was 61% (23 of 38 patients) for patients refractory to ibrutinib and 50% (5 of 10 patients) for those refractory to idelalisib. A complete response was seen in three patients, all refractory to ibrutinib.

Grade 3/4 adverse events were seen in over 10% of patients and included neutropenia (39%), thrombocytopenia (22%), anemia (20%), leukopenia (13%), and pneumonia (13%). Significant adverse events seen in at least two patients included pneumonia (9%), febrile neutropenia (7%), increased potassium, multiorgan failure, and septic shock (4% each).

The study is sponsored by AbbVie.

Venetoclax monotherapy was active, and even elicited minimal residual disease negativity in a proportion of patients with chronic lymphocytic leukemia (CLL) that was resistant or refractory to ibrutinib or idelalisib, Dr. Jeffrey Alan Jones of the Ohio State University Comprehensive Cancer Center, Columbus, and colleagues wrote in an abstract to be presented at the annual meeting of the American Society of Clinical Oncology.

The findings from their ongoing phase II study are the first prospective results to demonstrate efficacy in this poor-prognosis population, the researchers wrote. Earlier results from the study were reported at the American Society of Hematology meeting.

The 54 patients in the study, 25 of them refractory to ibrutinib and 6 to idelalisib, received venetoclax 20 mg daily followed by a 5-week ramp up in dosage to 400 mg daily. Over half of the patients had received more than five prior therapies; 83% did not have IGHV mutations, 20% had absolute lymphocyte counts exceeding 100 x 10⁹, 35% had 17p deletions, and 24% had at least one node that was 10 cm or larger.

Of the patients who had previously received ibrutinib, four discontinued venetoclax because of progressive disease and four others had respiratory failure, multiorgan failure, death of unknown cause, or consent withdrawal. Of those who previously received idelalisib, four halted therapy because of progressive disease and failure to respond. Of 48 evaluable patients, 38 previously received ibrutinib, and 10 previously received idelalisib.

The overall response rate was 61% (23 of 38 patients) for patients refractory to ibrutinib and 50% (5 of 10 patients) for those refractory to idelalisib. A complete response was seen in three patients, all refractory to ibrutinib.

Grade 3/4 adverse events were seen in over 10% of patients and included neutropenia (39%), thrombocytopenia (22%), anemia (20%), leukopenia (13%), and pneumonia (13%). Significant adverse events seen in at least two patients included pneumonia (9%), febrile neutropenia (7%), increased potassium, multiorgan failure, and septic shock (4% each).

The study is sponsored by AbbVie.

Venetoclax monotherapy was active, and even elicited minimal residual disease negativity in a proportion of patients with chronic lymphocytic leukemia (CLL) that was resistant or refractory to ibrutinib or idelalisib, Dr. Jeffrey Alan Jones of the Ohio State University Comprehensive Cancer Center, Columbus, and colleagues wrote in an abstract to be presented at the annual meeting of the American Society of Clinical Oncology.

The findings from their ongoing phase II study are the first prospective results to demonstrate efficacy in this poor-prognosis population, the researchers wrote. Earlier results from the study were reported at the American Society of Hematology meeting.

The 54 patients in the study, 25 of them refractory to ibrutinib and 6 to idelalisib, received venetoclax 20 mg daily followed by a 5-week ramp up in dosage to 400 mg daily. Over half of the patients had received more than five prior therapies; 83% did not have IGHV mutations, 20% had absolute lymphocyte counts exceeding 100 x 10⁹, 35% had 17p deletions, and 24% had at least one node that was 10 cm or larger.

Of the patients who had previously received ibrutinib, four discontinued venetoclax because of progressive disease and four others had respiratory failure, multiorgan failure, death of unknown cause, or consent withdrawal. Of those who previously received idelalisib, four halted therapy because of progressive disease and failure to respond. Of 48 evaluable patients, 38 previously received ibrutinib, and 10 previously received idelalisib.

The overall response rate was 61% (23 of 38 patients) for patients refractory to ibrutinib and 50% (5 of 10 patients) for those refractory to idelalisib. A complete response was seen in three patients, all refractory to ibrutinib.

Grade 3/4 adverse events were seen in over 10% of patients and included neutropenia (39%), thrombocytopenia (22%), anemia (20%), leukopenia (13%), and pneumonia (13%). Significant adverse events seen in at least two patients included pneumonia (9%), febrile neutropenia (7%), increased potassium, multiorgan failure, and septic shock (4% each).

The study is sponsored by AbbVie.

STOWE, VERMONT—Many treament options are available for migraine prevention. Developing customized treatment strategies for patients is essential. At the 26th Annual Stowe Headache Symposium of the Headache Cooperative of New England, Peter McAllister, MD, discussed the most efficacious migraine prevention therapies. He also gave guidance on deciding who needs preventive therapy and how to choose the right preventive treatment for each patient.

Who Needs Migraine Prevention Therapy?

Migraine prevention therapy is underutilized. Thirty-eight percent of patients could benefit from migraine prevention therapy, but only 3% to 13% are actually receiving it, according to 2012 guidelines from the AAN and the American Headache Society. Frequency of headaches and functional disability are the main criteria for deciding which patients need preventive treatment. According to the 2012 US Headache Consortium Guidelines, migraineurs with six or more headache days per month, four or more headache days with functional disability, or three or more headache days per month resulting in disability requiring bed rest, should be offered migraine preventive medication. The Canadian Prophylactic Guidelines Development Group 2012 recommended that prophylactic therapy be considered for patients whose migraine attacks have a significant impact on their lives, despite appropriate use of acute medications, trigger management, and lifestyle modification strategies.

Disability may be the more important of the two criteria. “If [a patient is] disabled, we really have to push and be aggressive with preventive medications,” said Dr. McAllister, Medical Director of the New England Institute for Neurology and Headache in Stamford, Connecticut. A guiding principle to consider when deciding who should receive preventive therapy is that an accurate diagnosis follows the International Headache Society, third edition (ICHD-3) guidelines. Dr. McAllister also advised doctors to make sure that patients keep headache diaries and to set realistic treatment goals. He also emphasized the importance of understanding patients’ medical and psychiatric conditions. In general, drug treatment should start with a low dose and slowly be titrated to a therapeutic dose. In addition, preventive treatment should be included as part of an overall plan that encompasses lifestyle changes, trigger reduction, and a strategy for withdrawal of medication.

Pharmacologic Options

The FDA has approved several drugs for migraine prevention, including divalproex sodium, topiramate, propranolol, timolol, and methysergide. Of all classes of migraine preventive therapy, antiseizure medications have the most support in the data. Topiramate is “a top choice” for migraine prevention because Class I evidence supports its efficacy and it is fairly well tolerated, said Dr. McAllister. Topiramate was also approved for children based on a double-blind study of participants between ages 12 and 17. Divalproex, another antiseizure medication, has high efficacy, but side effects such as weight gain, hair loss, tremor, teratogenicity, increased liver function tests, and increased risk for pancreatitis make the drug unattractive to many.

Antihypertensive medicines also may be used for migraine prevention. Much research supports the efficacy of beta blockers in migraine prevention, and doctors can help patients manage their associated side effects. Metoprolol, a beta blocker, may be more tolerable for someone with asthma or glucose issues because it is selective for β1. Although physicians have used verapamil, a calcium channel blocker, for migraine prevention, the most recent guidelines give a Level U recommendation for its use because of conflicting or insufficient evidence. Lisinopril, an angiotensin-converting-enzyme inhibitor, and candesartan, an angiotensin receptor blocking agent, have good side effect profiles. These drugs are recommended for patients with mild hypertension. American guidelines provide a Level C recommendation of clonidine, but Canadian guidelines recommend against using the drug because of insufficient evidence and concern about the side effects.

Nonpharmacologic Options

Neurologists who seek to avoid pharmacologic treatments may choose options such as biologics or neurostimulators. OnabotulinumtoxinA injections are approved for patients with chronic migraine. Administered properly, the treatment has no systemic side effects and few local side effects.

In 2014, the FDA allowed the Cefaly device, which stimulates the trigeminal nerve, to be marketed for the prevention of migraine. In 2013, 67 patients with migraine were randomized to supraorbital stimulation with Cefaly or sham stimulation. The number of headache days per month decreased from seven to five among the participants randomized to Cefaly. Patients who received sham stimulation had no change in this end point.

Some patients may be interested in complementary or alternative treatment options like biofeedback. Biofeedback allows patients to monitor and change certain physiologic parameters (eg, muscle contraction and skin temperature) and is used to treat insomnia and anxiety. This therapy can be combined with a migraine preventive drug for the best results. Controlled studies indicate that biofeedback can result in a 45% to 60% headache reduction. When combined with medication, biofeedback reduces headache by more than 70%. Children and adolescents can also benefit from this treatment.

Selecting Individualized Migraine Prevention Treatment

Once a neurologist has given a proper diagnosis, he or she should thoroughly review the patient’s profile to select the proper migraine prevention therapy. Gender, age, childbearing potential, and BMI are factors to consider when finding the best treatment for a given patient. “When you know you have to put someone on a medicine, you should know the side effects and be able to discuss them,” said Dr. McAllister. “I like to come up with a scatter plot in my head looking at increasing safety and tolerability on the y axis and increasing efficacy on the x axis…. If someone is really sensitive, you might want to aim towards the more tolerable medications.” For a patient with exceptionally painful headaches, it’s better to treat with highly efficacious drugs, despite their side effects, he added.

No migraine preventive therapy is pregnancy category A, said Dr. McAllister. None has been demonstrated safe for the unborn child. Nonsteroidal anti-inflammatory drugs are pregnancy category B and are recommended only during the first two trimesters. Metoclopramide and acetaminophen are also pregnancy category B. Category C drugs include amitriptyline, propranolol, verapamil, and onabotulinumtoxinA injections. Topiramate should not be used during pregnancy because it increases the risk for cleft palate in the child. Clear evidence indicates that divalproex is a teratogen.

Every patient with migraine should work with his or her doctor to find the most efficacious strategy for treatment. “What is the ideal migraine preventive drug? It should decrease the number of headache days or attacks, attenuate the intensity—of not just the pain, but the associated symptoms—render acute treatment, be effective, and have low or no side effects,” Dr. McAllister concluded.

—Erica Robinson

STOWE, VERMONT—Many treament options are available for migraine prevention. Developing customized treatment strategies for patients is essential. At the 26th Annual Stowe Headache Symposium of the Headache Cooperative of New England, Peter McAllister, MD, discussed the most efficacious migraine prevention therapies. He also gave guidance on deciding who needs preventive therapy and how to choose the right preventive treatment for each patient.

Who Needs Migraine Prevention Therapy?

Migraine prevention therapy is underutilized. Thirty-eight percent of patients could benefit from migraine prevention therapy, but only 3% to 13% are actually receiving it, according to 2012 guidelines from the AAN and the American Headache Society. Frequency of headaches and functional disability are the main criteria for deciding which patients need preventive treatment. According to the 2012 US Headache Consortium Guidelines, migraineurs with six or more headache days per month, four or more headache days with functional disability, or three or more headache days per month resulting in disability requiring bed rest, should be offered migraine preventive medication. The Canadian Prophylactic Guidelines Development Group 2012 recommended that prophylactic therapy be considered for patients whose migraine attacks have a significant impact on their lives, despite appropriate use of acute medications, trigger management, and lifestyle modification strategies.

Disability may be the more important of the two criteria. “If [a patient is] disabled, we really have to push and be aggressive with preventive medications,” said Dr. McAllister, Medical Director of the New England Institute for Neurology and Headache in Stamford, Connecticut. A guiding principle to consider when deciding who should receive preventive therapy is that an accurate diagnosis follows the International Headache Society, third edition (ICHD-3) guidelines. Dr. McAllister also advised doctors to make sure that patients keep headache diaries and to set realistic treatment goals. He also emphasized the importance of understanding patients’ medical and psychiatric conditions. In general, drug treatment should start with a low dose and slowly be titrated to a therapeutic dose. In addition, preventive treatment should be included as part of an overall plan that encompasses lifestyle changes, trigger reduction, and a strategy for withdrawal of medication.

Pharmacologic Options

The FDA has approved several drugs for migraine prevention, including divalproex sodium, topiramate, propranolol, timolol, and methysergide. Of all classes of migraine preventive therapy, antiseizure medications have the most support in the data. Topiramate is “a top choice” for migraine prevention because Class I evidence supports its efficacy and it is fairly well tolerated, said Dr. McAllister. Topiramate was also approved for children based on a double-blind study of participants between ages 12 and 17. Divalproex, another antiseizure medication, has high efficacy, but side effects such as weight gain, hair loss, tremor, teratogenicity, increased liver function tests, and increased risk for pancreatitis make the drug unattractive to many.

Antihypertensive medicines also may be used for migraine prevention. Much research supports the efficacy of beta blockers in migraine prevention, and doctors can help patients manage their associated side effects. Metoprolol, a beta blocker, may be more tolerable for someone with asthma or glucose issues because it is selective for β1. Although physicians have used verapamil, a calcium channel blocker, for migraine prevention, the most recent guidelines give a Level U recommendation for its use because of conflicting or insufficient evidence. Lisinopril, an angiotensin-converting-enzyme inhibitor, and candesartan, an angiotensin receptor blocking agent, have good side effect profiles. These drugs are recommended for patients with mild hypertension. American guidelines provide a Level C recommendation of clonidine, but Canadian guidelines recommend against using the drug because of insufficient evidence and concern about the side effects.

Nonpharmacologic Options

Neurologists who seek to avoid pharmacologic treatments may choose options such as biologics or neurostimulators. OnabotulinumtoxinA injections are approved for patients with chronic migraine. Administered properly, the treatment has no systemic side effects and few local side effects.

In 2014, the FDA allowed the Cefaly device, which stimulates the trigeminal nerve, to be marketed for the prevention of migraine. In 2013, 67 patients with migraine were randomized to supraorbital stimulation with Cefaly or sham stimulation. The number of headache days per month decreased from seven to five among the participants randomized to Cefaly. Patients who received sham stimulation had no change in this end point.

Some patients may be interested in complementary or alternative treatment options like biofeedback. Biofeedback allows patients to monitor and change certain physiologic parameters (eg, muscle contraction and skin temperature) and is used to treat insomnia and anxiety. This therapy can be combined with a migraine preventive drug for the best results. Controlled studies indicate that biofeedback can result in a 45% to 60% headache reduction. When combined with medication, biofeedback reduces headache by more than 70%. Children and adolescents can also benefit from this treatment.

Selecting Individualized Migraine Prevention Treatment

Once a neurologist has given a proper diagnosis, he or she should thoroughly review the patient’s profile to select the proper migraine prevention therapy. Gender, age, childbearing potential, and BMI are factors to consider when finding the best treatment for a given patient. “When you know you have to put someone on a medicine, you should know the side effects and be able to discuss them,” said Dr. McAllister. “I like to come up with a scatter plot in my head looking at increasing safety and tolerability on the y axis and increasing efficacy on the x axis…. If someone is really sensitive, you might want to aim towards the more tolerable medications.” For a patient with exceptionally painful headaches, it’s better to treat with highly efficacious drugs, despite their side effects, he added.

No migraine preventive therapy is pregnancy category A, said Dr. McAllister. None has been demonstrated safe for the unborn child. Nonsteroidal anti-inflammatory drugs are pregnancy category B and are recommended only during the first two trimesters. Metoclopramide and acetaminophen are also pregnancy category B. Category C drugs include amitriptyline, propranolol, verapamil, and onabotulinumtoxinA injections. Topiramate should not be used during pregnancy because it increases the risk for cleft palate in the child. Clear evidence indicates that divalproex is a teratogen.

Every patient with migraine should work with his or her doctor to find the most efficacious strategy for treatment. “What is the ideal migraine preventive drug? It should decrease the number of headache days or attacks, attenuate the intensity—of not just the pain, but the associated symptoms—render acute treatment, be effective, and have low or no side effects,” Dr. McAllister concluded.

—Erica Robinson

STOWE, VERMONT—Many treament options are available for migraine prevention. Developing customized treatment strategies for patients is essential. At the 26th Annual Stowe Headache Symposium of the Headache Cooperative of New England, Peter McAllister, MD, discussed the most efficacious migraine prevention therapies. He also gave guidance on deciding who needs preventive therapy and how to choose the right preventive treatment for each patient.

Who Needs Migraine Prevention Therapy?

Migraine prevention therapy is underutilized. Thirty-eight percent of patients could benefit from migraine prevention therapy, but only 3% to 13% are actually receiving it, according to 2012 guidelines from the AAN and the American Headache Society. Frequency of headaches and functional disability are the main criteria for deciding which patients need preventive treatment. According to the 2012 US Headache Consortium Guidelines, migraineurs with six or more headache days per month, four or more headache days with functional disability, or three or more headache days per month resulting in disability requiring bed rest, should be offered migraine preventive medication. The Canadian Prophylactic Guidelines Development Group 2012 recommended that prophylactic therapy be considered for patients whose migraine attacks have a significant impact on their lives, despite appropriate use of acute medications, trigger management, and lifestyle modification strategies.

Disability may be the more important of the two criteria. “If [a patient is] disabled, we really have to push and be aggressive with preventive medications,” said Dr. McAllister, Medical Director of the New England Institute for Neurology and Headache in Stamford, Connecticut. A guiding principle to consider when deciding who should receive preventive therapy is that an accurate diagnosis follows the International Headache Society, third edition (ICHD-3) guidelines. Dr. McAllister also advised doctors to make sure that patients keep headache diaries and to set realistic treatment goals. He also emphasized the importance of understanding patients’ medical and psychiatric conditions. In general, drug treatment should start with a low dose and slowly be titrated to a therapeutic dose. In addition, preventive treatment should be included as part of an overall plan that encompasses lifestyle changes, trigger reduction, and a strategy for withdrawal of medication.

Pharmacologic Options

The FDA has approved several drugs for migraine prevention, including divalproex sodium, topiramate, propranolol, timolol, and methysergide. Of all classes of migraine preventive therapy, antiseizure medications have the most support in the data. Topiramate is “a top choice” for migraine prevention because Class I evidence supports its efficacy and it is fairly well tolerated, said Dr. McAllister. Topiramate was also approved for children based on a double-blind study of participants between ages 12 and 17. Divalproex, another antiseizure medication, has high efficacy, but side effects such as weight gain, hair loss, tremor, teratogenicity, increased liver function tests, and increased risk for pancreatitis make the drug unattractive to many.

Antihypertensive medicines also may be used for migraine prevention. Much research supports the efficacy of beta blockers in migraine prevention, and doctors can help patients manage their associated side effects. Metoprolol, a beta blocker, may be more tolerable for someone with asthma or glucose issues because it is selective for β1. Although physicians have used verapamil, a calcium channel blocker, for migraine prevention, the most recent guidelines give a Level U recommendation for its use because of conflicting or insufficient evidence. Lisinopril, an angiotensin-converting-enzyme inhibitor, and candesartan, an angiotensin receptor blocking agent, have good side effect profiles. These drugs are recommended for patients with mild hypertension. American guidelines provide a Level C recommendation of clonidine, but Canadian guidelines recommend against using the drug because of insufficient evidence and concern about the side effects.

Nonpharmacologic Options

Neurologists who seek to avoid pharmacologic treatments may choose options such as biologics or neurostimulators. OnabotulinumtoxinA injections are approved for patients with chronic migraine. Administered properly, the treatment has no systemic side effects and few local side effects.

In 2014, the FDA allowed the Cefaly device, which stimulates the trigeminal nerve, to be marketed for the prevention of migraine. In 2013, 67 patients with migraine were randomized to supraorbital stimulation with Cefaly or sham stimulation. The number of headache days per month decreased from seven to five among the participants randomized to Cefaly. Patients who received sham stimulation had no change in this end point.

Some patients may be interested in complementary or alternative treatment options like biofeedback. Biofeedback allows patients to monitor and change certain physiologic parameters (eg, muscle contraction and skin temperature) and is used to treat insomnia and anxiety. This therapy can be combined with a migraine preventive drug for the best results. Controlled studies indicate that biofeedback can result in a 45% to 60% headache reduction. When combined with medication, biofeedback reduces headache by more than 70%. Children and adolescents can also benefit from this treatment.

Selecting Individualized Migraine Prevention Treatment

Once a neurologist has given a proper diagnosis, he or she should thoroughly review the patient’s profile to select the proper migraine prevention therapy. Gender, age, childbearing potential, and BMI are factors to consider when finding the best treatment for a given patient. “When you know you have to put someone on a medicine, you should know the side effects and be able to discuss them,” said Dr. McAllister. “I like to come up with a scatter plot in my head looking at increasing safety and tolerability on the y axis and increasing efficacy on the x axis…. If someone is really sensitive, you might want to aim towards the more tolerable medications.” For a patient with exceptionally painful headaches, it’s better to treat with highly efficacious drugs, despite their side effects, he added.

No migraine preventive therapy is pregnancy category A, said Dr. McAllister. None has been demonstrated safe for the unborn child. Nonsteroidal anti-inflammatory drugs are pregnancy category B and are recommended only during the first two trimesters. Metoclopramide and acetaminophen are also pregnancy category B. Category C drugs include amitriptyline, propranolol, verapamil, and onabotulinumtoxinA injections. Topiramate should not be used during pregnancy because it increases the risk for cleft palate in the child. Clear evidence indicates that divalproex is a teratogen.

Every patient with migraine should work with his or her doctor to find the most efficacious strategy for treatment. “What is the ideal migraine preventive drug? It should decrease the number of headache days or attacks, attenuate the intensity—of not just the pain, but the associated symptoms—render acute treatment, be effective, and have low or no side effects,” Dr. McAllister concluded.

—Erica Robinson

VANCOUVER—Elevated systolic blood pressure predicts worsening motor function among patients with Parkinson’s disease, according to research presented at the 68th Annual Meeting of the American Academy of Neurology. Male gender and treatment with lower doses of dopaminergic medications also increase the risk of motor decline in these individuals, said Christina Lineback, a medical student at the University of Michigan in Ann Arbor.

Christina Lineback

Previous data have suggested that the presence and severity of comorbid brain pathologies may explain differences in disease progression between patients with Parkinson’s disease. In 2014, investigators at the University of Michigan found that cardiovascular risk factors such as hypertension, age, and diabetes influence the rate of motor disability accumulation in Parkinson’s disease.

Because high systolic blood pressure is a risk factor for the development of white matter hyperintensities, which in turn correlate with an increased rate of motor disability accumulation, Ms. Lineback and colleagues examined whether blood pressure predicted motor outcomes in patients with Parkinson’s disease. They performed a retrospective analysis of data from the CALM-PD trial, a two-year longitudinal study of 275 participants with Parkinson’s disease who were followed for 102 weeks. Each patient underwent several motor examinations using the Unified Parkinson’s Disease Rating Scale III (UPDRS III), as well as blood pressure measurements. The researchers examined mean systolic blood pressure using a multivariable linear-regression model that controlled for age, sex, disease duration, treatment arm, treatment dose, and open-label levodopa dose equivalence. Motor outcomes were determined by calculating the change in UPDRS III “on” scores from week 4 to week 102.

The study cohort of 275 patients with early Parkinson’s disease included 176 men and 99 women. Participants’ mean age was 60, and mean disease duration was 1.6 years. The overall mean systolic blood pressure was 130 mm Hg. Elevated mean systolic blood pressure was significantly associated with a greater decline in UPDRS III motor scores. In addition, male gender, randomization to pramipexole, and randomization to the lowest drug dose negatively affected motor performance.

Ms. Lineback offered several possible explanations for the association between elevated systolic blood pressure and worsening UPDRS III scores. High blood pressure may have a direct toxic effect on the brain that promotes the loss of neuronal integrity, she said. “Alternatively, elevated systolic blood pressure could serve as a trait marker for other unmeasured pathology … such as other cardiovascular risk factors.” In addition, the association may result from the autonomic dysfunction that is common in Parkinson’s disease. Lastly, the association could result from other unmeasured independent risk factors for motor decline, such as osteoarthritis or socioeconomic status.

One limitation of the study was the lack of information about other disease pathologies that could influence motor score, such as chronic conditions. In addition, the researchers did not account for the use of different classes of blood pressure medications.

“Identifying clinical features associated with more aggressive disease progression in Parkinson’s disease, such as blood pressure, may be important in future studies,” said Ms. Lineback. “Researchers may begin to incorporate these baseline prognostic markers into the randomization stage of future clinical trials.”

—Erik Greb

VANCOUVER—Elevated systolic blood pressure predicts worsening motor function among patients with Parkinson’s disease, according to research presented at the 68th Annual Meeting of the American Academy of Neurology. Male gender and treatment with lower doses of dopaminergic medications also increase the risk of motor decline in these individuals, said Christina Lineback, a medical student at the University of Michigan in Ann Arbor.

Christina Lineback

Previous data have suggested that the presence and severity of comorbid brain pathologies may explain differences in disease progression between patients with Parkinson’s disease. In 2014, investigators at the University of Michigan found that cardiovascular risk factors such as hypertension, age, and diabetes influence the rate of motor disability accumulation in Parkinson’s disease.

Because high systolic blood pressure is a risk factor for the development of white matter hyperintensities, which in turn correlate with an increased rate of motor disability accumulation, Ms. Lineback and colleagues examined whether blood pressure predicted motor outcomes in patients with Parkinson’s disease. They performed a retrospective analysis of data from the CALM-PD trial, a two-year longitudinal study of 275 participants with Parkinson’s disease who were followed for 102 weeks. Each patient underwent several motor examinations using the Unified Parkinson’s Disease Rating Scale III (UPDRS III), as well as blood pressure measurements. The researchers examined mean systolic blood pressure using a multivariable linear-regression model that controlled for age, sex, disease duration, treatment arm, treatment dose, and open-label levodopa dose equivalence. Motor outcomes were determined by calculating the change in UPDRS III “on” scores from week 4 to week 102.

The study cohort of 275 patients with early Parkinson’s disease included 176 men and 99 women. Participants’ mean age was 60, and mean disease duration was 1.6 years. The overall mean systolic blood pressure was 130 mm Hg. Elevated mean systolic blood pressure was significantly associated with a greater decline in UPDRS III motor scores. In addition, male gender, randomization to pramipexole, and randomization to the lowest drug dose negatively affected motor performance.

Ms. Lineback offered several possible explanations for the association between elevated systolic blood pressure and worsening UPDRS III scores. High blood pressure may have a direct toxic effect on the brain that promotes the loss of neuronal integrity, she said. “Alternatively, elevated systolic blood pressure could serve as a trait marker for other unmeasured pathology … such as other cardiovascular risk factors.” In addition, the association may result from the autonomic dysfunction that is common in Parkinson’s disease. Lastly, the association could result from other unmeasured independent risk factors for motor decline, such as osteoarthritis or socioeconomic status.

One limitation of the study was the lack of information about other disease pathologies that could influence motor score, such as chronic conditions. In addition, the researchers did not account for the use of different classes of blood pressure medications.

“Identifying clinical features associated with more aggressive disease progression in Parkinson’s disease, such as blood pressure, may be important in future studies,” said Ms. Lineback. “Researchers may begin to incorporate these baseline prognostic markers into the randomization stage of future clinical trials.”

—Erik Greb

VANCOUVER—Elevated systolic blood pressure predicts worsening motor function among patients with Parkinson’s disease, according to research presented at the 68th Annual Meeting of the American Academy of Neurology. Male gender and treatment with lower doses of dopaminergic medications also increase the risk of motor decline in these individuals, said Christina Lineback, a medical student at the University of Michigan in Ann Arbor.

Christina Lineback

Previous data have suggested that the presence and severity of comorbid brain pathologies may explain differences in disease progression between patients with Parkinson’s disease. In 2014, investigators at the University of Michigan found that cardiovascular risk factors such as hypertension, age, and diabetes influence the rate of motor disability accumulation in Parkinson’s disease.

Because high systolic blood pressure is a risk factor for the development of white matter hyperintensities, which in turn correlate with an increased rate of motor disability accumulation, Ms. Lineback and colleagues examined whether blood pressure predicted motor outcomes in patients with Parkinson’s disease. They performed a retrospective analysis of data from the CALM-PD trial, a two-year longitudinal study of 275 participants with Parkinson’s disease who were followed for 102 weeks. Each patient underwent several motor examinations using the Unified Parkinson’s Disease Rating Scale III (UPDRS III), as well as blood pressure measurements. The researchers examined mean systolic blood pressure using a multivariable linear-regression model that controlled for age, sex, disease duration, treatment arm, treatment dose, and open-label levodopa dose equivalence. Motor outcomes were determined by calculating the change in UPDRS III “on” scores from week 4 to week 102.

The study cohort of 275 patients with early Parkinson’s disease included 176 men and 99 women. Participants’ mean age was 60, and mean disease duration was 1.6 years. The overall mean systolic blood pressure was 130 mm Hg. Elevated mean systolic blood pressure was significantly associated with a greater decline in UPDRS III motor scores. In addition, male gender, randomization to pramipexole, and randomization to the lowest drug dose negatively affected motor performance.

Ms. Lineback offered several possible explanations for the association between elevated systolic blood pressure and worsening UPDRS III scores. High blood pressure may have a direct toxic effect on the brain that promotes the loss of neuronal integrity, she said. “Alternatively, elevated systolic blood pressure could serve as a trait marker for other unmeasured pathology … such as other cardiovascular risk factors.” In addition, the association may result from the autonomic dysfunction that is common in Parkinson’s disease. Lastly, the association could result from other unmeasured independent risk factors for motor decline, such as osteoarthritis or socioeconomic status.

One limitation of the study was the lack of information about other disease pathologies that could influence motor score, such as chronic conditions. In addition, the researchers did not account for the use of different classes of blood pressure medications.

“Identifying clinical features associated with more aggressive disease progression in Parkinson’s disease, such as blood pressure, may be important in future studies,” said Ms. Lineback. “Researchers may begin to incorporate these baseline prognostic markers into the randomization stage of future clinical trials.”

—Erik Greb

Abemaciclib, a CDK4/6 inhibitor, showed durable clinical activity when given as continuous single-agent therapy to patients with advanced cancer, including breast cancer and non–small-cell lung cancer, according to investigators.

Neutropenia was rarely observed in patients treated with abemaciclib, the toxicity observed in some patients who receive the only Food and Drug Administration–approved CDK4/6 inhibitor, palbociclib.

“Abemaciclib is a small-molecule inhibitor of CDK4 and CDK6 that is structurally distinct from other dual inhibitors (such as palbociclib and ribociclib) and notably exhibits greater selectivity for CDK4 compared with CDK6,” wrote Dr. Amita Patnaik of South Texas Accelerated Research Therapeutics and her associates (Cancer Discov. 2016 May 23. doi: 10.1158/2159-8290.CD-16-0095).

Furthermore, preclinical models indicate that the drug can cross the blood-brain barrier, suggesting potential efficacy against primary and metastatic tumors involving the central nervous system, they said.

A total of 225 patients with various types of advanced cancers were enrolled in this multicohort phase I study (dose escalation, n = 33; single-agent abemaciclib therapy for breast cancer, n = 47; non–small-cell lung cancer, n = 68; glioblastoma, n = 17; melanoma, n = 26; colorectal cancer, n = 15; abemaciclib plus fulvestrant combination therapy for hormone receptor–positive breast cancer, n = 19). Abemaciclib was given orally to all patients.

Neither dose-limiting toxicity nor maximum tolerated dose was reached in patients treated at levels of 50 mg, 100 mg, 150 mg, or 225 mg once daily. The maximum tolerated dose was 200 mg for patients treated with abemaciclib twice daily.

In the single-agent breast cancer cohort, the disease control rate was 81% for hormone receptor–positive (HR-positive) tumors, 33% for HR-negative tumors, 100% for HR-positive HER2-positive tumors, 72% for HR-positive HER2-negative tumors, and 70% overall. The response rate was 31% for HR-positive tumors, 0% for HR-negative tumors, 36% for HR-positive HER2-positive tumors, 28% for HR-positive HER2-negative tumors, and 23% overall.

The overall response rate was 21% for breast cancer patients receiving abemaciclib plus fulvestrant.

Among the 68 patients with non–small-cell lung cancer, 2 had a partial response and 31 had stable disease. Of the 26 patients with melanoma, 1 had a partial response and 6 had stable disease. Of the 17 patients with glioblastoma, 3 had stable disease.

Overall, there were no study-related deaths. Diarrhea, nausea, and fatigue were the most common adverse events; all were reversible.

Neutropenia was observed in 39 patients (23% of 173 patients in the single-agent tumor-specific cohort) – 2 were grade 4 events. Grade 3 neutropenia occurred in 6 patients (32% of 19 patients with HR-positive breast cancer receiving combination therapy with abemaciclib plus fulvestrant).

“Previous reports have identified neutropenia as an adverse event associated with dual inhibition of CDK4 and CDK6. However, abemaciclib given as a single agent on a continuous schedule in the tumor-specific cohorts was associated with an acceptable incidence of investigator-reported grade 3 (9%, 16 of 173 patients) or grade 4 (1%, 2 of 173 patients) neutropenia,” wrote the investigators.

“In summary, the results of this clinical trial demonstrate the safety and antitumor activity of abemaciclib as a single agent and support its further development both as monotherapy and in rational combinations. Furthermore, these findings validate CDK4 and CDK6 as anticancer drug targets and translate preclinical predictions regarding therapeutic targeting of cell-cycle derangements in cancer into clinical efficacy,”they wrote.

Eli Lilly funded the study. Eight investigators reported serving in advisory roles, having ownership or stock interest in, or receiving financial compensation from multiple companies including Eli Lilly.

[email protected]

On Twitter @JessCraig_OP

Abemaciclib, a CDK4/6 inhibitor, showed durable clinical activity when given as continuous single-agent therapy to patients with advanced cancer, including breast cancer and non–small-cell lung cancer, according to investigators.

Neutropenia was rarely observed in patients treated with abemaciclib, the toxicity observed in some patients who receive the only Food and Drug Administration–approved CDK4/6 inhibitor, palbociclib.

“Abemaciclib is a small-molecule inhibitor of CDK4 and CDK6 that is structurally distinct from other dual inhibitors (such as palbociclib and ribociclib) and notably exhibits greater selectivity for CDK4 compared with CDK6,” wrote Dr. Amita Patnaik of South Texas Accelerated Research Therapeutics and her associates (Cancer Discov. 2016 May 23. doi: 10.1158/2159-8290.CD-16-0095).

Furthermore, preclinical models indicate that the drug can cross the blood-brain barrier, suggesting potential efficacy against primary and metastatic tumors involving the central nervous system, they said.

A total of 225 patients with various types of advanced cancers were enrolled in this multicohort phase I study (dose escalation, n = 33; single-agent abemaciclib therapy for breast cancer, n = 47; non–small-cell lung cancer, n = 68; glioblastoma, n = 17; melanoma, n = 26; colorectal cancer, n = 15; abemaciclib plus fulvestrant combination therapy for hormone receptor–positive breast cancer, n = 19). Abemaciclib was given orally to all patients.

Neither dose-limiting toxicity nor maximum tolerated dose was reached in patients treated at levels of 50 mg, 100 mg, 150 mg, or 225 mg once daily. The maximum tolerated dose was 200 mg for patients treated with abemaciclib twice daily.

In the single-agent breast cancer cohort, the disease control rate was 81% for hormone receptor–positive (HR-positive) tumors, 33% for HR-negative tumors, 100% for HR-positive HER2-positive tumors, 72% for HR-positive HER2-negative tumors, and 70% overall. The response rate was 31% for HR-positive tumors, 0% for HR-negative tumors, 36% for HR-positive HER2-positive tumors, 28% for HR-positive HER2-negative tumors, and 23% overall.

The overall response rate was 21% for breast cancer patients receiving abemaciclib plus fulvestrant.

Among the 68 patients with non–small-cell lung cancer, 2 had a partial response and 31 had stable disease. Of the 26 patients with melanoma, 1 had a partial response and 6 had stable disease. Of the 17 patients with glioblastoma, 3 had stable disease.

Overall, there were no study-related deaths. Diarrhea, nausea, and fatigue were the most common adverse events; all were reversible.

Neutropenia was observed in 39 patients (23% of 173 patients in the single-agent tumor-specific cohort) – 2 were grade 4 events. Grade 3 neutropenia occurred in 6 patients (32% of 19 patients with HR-positive breast cancer receiving combination therapy with abemaciclib plus fulvestrant).

“Previous reports have identified neutropenia as an adverse event associated with dual inhibition of CDK4 and CDK6. However, abemaciclib given as a single agent on a continuous schedule in the tumor-specific cohorts was associated with an acceptable incidence of investigator-reported grade 3 (9%, 16 of 173 patients) or grade 4 (1%, 2 of 173 patients) neutropenia,” wrote the investigators.

“In summary, the results of this clinical trial demonstrate the safety and antitumor activity of abemaciclib as a single agent and support its further development both as monotherapy and in rational combinations. Furthermore, these findings validate CDK4 and CDK6 as anticancer drug targets and translate preclinical predictions regarding therapeutic targeting of cell-cycle derangements in cancer into clinical efficacy,”they wrote.

Eli Lilly funded the study. Eight investigators reported serving in advisory roles, having ownership or stock interest in, or receiving financial compensation from multiple companies including Eli Lilly.

[email protected]

On Twitter @JessCraig_OP

Abemaciclib, a CDK4/6 inhibitor, showed durable clinical activity when given as continuous single-agent therapy to patients with advanced cancer, including breast cancer and non–small-cell lung cancer, according to investigators.

Neutropenia was rarely observed in patients treated with abemaciclib, the toxicity observed in some patients who receive the only Food and Drug Administration–approved CDK4/6 inhibitor, palbociclib.

“Abemaciclib is a small-molecule inhibitor of CDK4 and CDK6 that is structurally distinct from other dual inhibitors (such as palbociclib and ribociclib) and notably exhibits greater selectivity for CDK4 compared with CDK6,” wrote Dr. Amita Patnaik of South Texas Accelerated Research Therapeutics and her associates (Cancer Discov. 2016 May 23. doi: 10.1158/2159-8290.CD-16-0095).

Furthermore, preclinical models indicate that the drug can cross the blood-brain barrier, suggesting potential efficacy against primary and metastatic tumors involving the central nervous system, they said.

A total of 225 patients with various types of advanced cancers were enrolled in this multicohort phase I study (dose escalation, n = 33; single-agent abemaciclib therapy for breast cancer, n = 47; non–small-cell lung cancer, n = 68; glioblastoma, n = 17; melanoma, n = 26; colorectal cancer, n = 15; abemaciclib plus fulvestrant combination therapy for hormone receptor–positive breast cancer, n = 19). Abemaciclib was given orally to all patients.

Neither dose-limiting toxicity nor maximum tolerated dose was reached in patients treated at levels of 50 mg, 100 mg, 150 mg, or 225 mg once daily. The maximum tolerated dose was 200 mg for patients treated with abemaciclib twice daily.

In the single-agent breast cancer cohort, the disease control rate was 81% for hormone receptor–positive (HR-positive) tumors, 33% for HR-negative tumors, 100% for HR-positive HER2-positive tumors, 72% for HR-positive HER2-negative tumors, and 70% overall. The response rate was 31% for HR-positive tumors, 0% for HR-negative tumors, 36% for HR-positive HER2-positive tumors, 28% for HR-positive HER2-negative tumors, and 23% overall.

The overall response rate was 21% for breast cancer patients receiving abemaciclib plus fulvestrant.

Among the 68 patients with non–small-cell lung cancer, 2 had a partial response and 31 had stable disease. Of the 26 patients with melanoma, 1 had a partial response and 6 had stable disease. Of the 17 patients with glioblastoma, 3 had stable disease.

Overall, there were no study-related deaths. Diarrhea, nausea, and fatigue were the most common adverse events; all were reversible.

Neutropenia was observed in 39 patients (23% of 173 patients in the single-agent tumor-specific cohort) – 2 were grade 4 events. Grade 3 neutropenia occurred in 6 patients (32% of 19 patients with HR-positive breast cancer receiving combination therapy with abemaciclib plus fulvestrant).

“Previous reports have identified neutropenia as an adverse event associated with dual inhibition of CDK4 and CDK6. However, abemaciclib given as a single agent on a continuous schedule in the tumor-specific cohorts was associated with an acceptable incidence of investigator-reported grade 3 (9%, 16 of 173 patients) or grade 4 (1%, 2 of 173 patients) neutropenia,” wrote the investigators.

“In summary, the results of this clinical trial demonstrate the safety and antitumor activity of abemaciclib as a single agent and support its further development both as monotherapy and in rational combinations. Furthermore, these findings validate CDK4 and CDK6 as anticancer drug targets and translate preclinical predictions regarding therapeutic targeting of cell-cycle derangements in cancer into clinical efficacy,”they wrote.

Eli Lilly funded the study. Eight investigators reported serving in advisory roles, having ownership or stock interest in, or receiving financial compensation from multiple companies including Eli Lilly.

[email protected]

On Twitter @JessCraig_OP